Hub : Genes

TANK

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Nucleus accumbens basal ganglia	0.1930	0.0800	0.0021	0.004	NA	0.018	NA	0.031	2.4e-01	NA	1.0e-01	NA	5.0e-02
2	GTEx	Cells Transformed fibroblasts	0.1020	0.0490	0.0031	0.030	NA	0.065	NA	0.038	2.3e-03	NA	1.2e-05	NA	7.0e-04
3	GTEx	Muscle Skeletal	0.0722	0.0273	0.0016	0.057	NA	0.027	NA	0.039	2.9e-06	NA	9.3e-04	NA	8.9e-05
4	NTR	Blood	0.0191	0.0080	0.0014	0.023	0.011	0.018	0.013	0.019	4.5e-08	0.00012	1.2e-06	2.6e-05	8.7e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.4	1.2	-0.1	-1.1	-0.1	-0.4
Bipolar Disorder or Schizophrenia	1.3	3.2	5.1	1.6	0.9	-2.1	-2.3
Depressed Affect (Nagel 2018)	5.4	11.3	21.6	-0.2	1.8	-4.5	-4.6
Depression (Nagel 2018)	3.6	5.4	10.3	-0.3	1.4	-3.1	-3.2
Intelligence (Savage-Jansen 2018)	9.8	30.0	56.9	-2.2	-2.1	7.5	7.3
Neuroticism (Nagel 2018)	2.3	5.4	10.1	-0.7	1.6	-2.9	-3.2
Schizophrenia (2018)	2.7	5.6	7.2	2.2	2.1	-2.7	-2.5
Schizophrenia vs Biploar Disorder	1.8	2.4	6.1	1.9	2.5	-0.2	0.1
Worry (Nagel 2018)	0.3	0.5	1.3	-0.8	1.2	-0.2	-0.5
Alzheimer’s Disease (in mother)	0.4	0.4	1.0	0.1	-0.0	1.0	0.9
Alzheimer’s Disease (in father)	0.8	0.9	2.0	0.7	1.4	-0.6	-0.7
Alzheimer’s Disease (including proxy)	0.9	1.2	2.0	0.9	1.4	1.1	1.0
Crohns Disease (2017)	0.3	0.7	1.3	-0.7	-0.3	-1.0	-1.1
Irritable Bowel Disease (IBD)	0.3	0.8	1.6	-0.4	-0.2	1.3	1.1
Ulcerative Colitis (UC)	2.0	3.8	7.7	0.2	0.5	2.8	2.7
Major Depression (MDD)	0.1	0.1	0.3	-0.5	-0.3	-0.1	-0.2
Reaction Time	2.1	3.9	7.5	1.0	0.9	-2.6	-2.7
Verbal and Numeric Reasoning (VNR)	7.0	16.8	33.2	-1.1	-0.9	5.8	5.7
Breast Cancer	0.7	1.6	3.1	-0.9	-0.6	-1.5	-1.8
Ovarian Cancer	0.9	1.2	2.0	0.0	-1.2	-1.1	-1.4
Prostate Cancer	0.9	1.3	4.0	-0.6	2.0	-0.6	-0.7
Age at First Birth	0.2	0.3	0.5	0.3	-0.7	0.6	0.4
Bipolar Disorder (2011)	1.9	1.8	3.3	-1.3	-1.8	-1.0	-1.1
Body Mass Index (BMI) (2010)	0.3	0.5	0.8	-0.6	-0.1	-0.9	-0.9
Coronary Artery Disease (CAD)	0.5	0.6	1.5	-1.2	-0.9	-0.1	-0.0
Crohns Disease (2012)	0.5	0.7	1.2	-0.6	-0.8	-0.9	-1.1
Mean Putamen Volume	1.7	2.0	2.9	0.7	1.7	-1.5	-1.5
Fasting Glucose	1.1	1.3	3.9	-2.0	0.5	0.6	0.7
HbA1C	0.8	0.9	1.0	-0.9	-0.9	1.0	0.9
HDL Cholesterol	0.4	0.7	0.9	-0.2	1.0	1.0	0.9
LDL Cholesterol	0.3	0.5	1.1	-1.0	-0.1	0.7	0.7
Lupus	0.1	0.1	0.2	-0.1	0.5	0.1	0.3
Neuroticism (2016)	8.5	12.3	19.4	1.7	2.8	-4.4	-4.4
Primary Biliary Cirrhosis	0.7	1.1	1.7	0.3	-0.9	1.3	1.3
Rheumatoid Arthritis	1.1	1.5	2.8	1.7	1.5	0.7	0.8
Schizophrenia (2014)	2.0	4.4	5.6	2.4	2.1	-2.0	-1.9
Triglycerides	0.2	0.3	0.6	-0.8	-0.8	-0.1	-0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.1	-0.2	-0.8	-0.8
Ulcerative Colitis	2.2	3.2	6.5	-0.0	-0.3	2.6	2.5
Blood Eosinophil Count	0.8	6.3	7.2	2.5	-2.1	-2.7	-2.7
Blood Platelet Count	0.3	3.7	4.3	-2.0	-1.6	2.1	2.0
Blood Red Count	0.1	0.9	1.8	-0.4	0.1	1.3	1.4
Blood White Count	0.4	3.3	8.5	-2.1	-2.9	0.4	0.1
Heel T-Score	0.3	2.4	3.8	0.3	-1.9	1.8	1.6
BMI	0.9	5.4	7.1	-1.0	-2.7	-2.6	-2.6
Height	0.2	3.6	6.0	-1.5	-0.9	2.5	2.3
Waist Hip Ratio (WHR)	0.3	1.2	2.3	-1.5	1.0	1.0	0.7
Systolic Blood Pressure	1.2	5.8	7.4	2.7	1.4	-2.7	-2.5
Smoking Status	8.3	19.8	35.1	2.5	1.7	-5.9	-5.9
Allergy or Eczema	0.0	0.0	0.1	0.3	-0.2	0.2	-0.1
Cardiovascular Disease	1.4	4.5	8.7	0.2	-0.7	-3.0	-2.9
Hypothyroidism (self reported)	8.5	19.6	35.8	2.7	1.1	-5.8	-6.0
Respiratory disease	0.2	0.4	1.2	-1.1	-0.5	0.1	-0.1
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.2	-1.5	-1.3	-0.7	-0.9
Lung FEV1/FVC ratio	0.3	1.6	6.1	0.4	2.5	-0.2	-0.2
Lung FVC	0.4	2.1	3.4	-0.9	-1.2	1.6	1.8
Neuroticism	2.3	5.6	11.0	-0.6	1.2	-3.1	-3.3
Chronotype (morning person)	2.9	6.7	12.5	-3.5	-1.9	2.4	2.2
Hair Pigment	0.0	0.9	3.4	-0.2	-1.9	-0.2	-0.2
Tanning	0.1	1.5	2.7	1.6	1.4	-0.8	-0.6
Hand grip strength (left)	0.6	1.6	4.5	2.1	1.1	-0.8	-0.5
Number of treatments/medications taken	7.1	12.8	24.1	1.6	0.7	-4.9	-4.9
Average weekly spirits intake	3.0	3.7	6.8	0.9	1.1	-2.4	-2.6
Sensitivity / hurt feelings	2.0	3.5	6.1	-0.4	1.6	-2.3	-2.5
Frequency of depressed mood in last 2 weeks	3.1	4.4	8.2	0.8	1.0	-2.8	-2.9
Hearing difficulty/problems: Yes	1.6	2.4	7.4	-1.5	-2.7	0.2	0.0
Relative age of first facial hair	0.3	0.7	2.1	-1.5	0.4	0.4	0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	0.6	0.6	-0.2	-0.2
Ever used hormone-replacement therapy (HRT)	1.5	1.9	2.9	-0.1	-1.4	-1.6	-1.7
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	0.0	-0.3	-0.9	-1.0
Systolic blood pressure, automated reading	1.0	3.0	4.9	1.6	0.4	-2.2	-2.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.5	-0.5	-0.2	-0.3
Angina	0.6	0.7	0.8	0.8	-0.9	-0.8	-0.9
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.0	-0.4	-0.5	-0.5
Vitamin and mineral supplements	2.4	3.2	6.2	-0.2	0.9	2.4	2.5
Supplements: Zinc	1.5	1.7	3.3	-0.6	-0.0	-1.7	-1.8
Medication: Co-codamol	1.2	1.4	2.6	0.9	0.1	-1.6	-1.5
Medication: Metformin	1.3	1.8	3.5	-1.9	-1.8	-0.4	-0.5
Diabetes (father)	0.8	1.0	1.3	-1.1	-1.1	-0.7	-1.0
Diabetes (mother)	1.1	1.4	2.3	-1.5	-0.9	1.2	1.1
Severe depression (siblings)	3.7	4.2	4.4	2.0	-2.0	-2.0	-2.1
Pack years adult smoking proportion	0.2	0.3	0.9	-0.6	-0.9	-0.1	-0.1
Impedance of leg (right)	0.3	1.2	3.7	1.1	1.9	-0.2	-0.1
Leg fat-free mass (left)	0.7	3.8	7.8	-2.5	-2.8	0.8	0.6
Trunk fat percentage	1.3	5.3	7.8	-2.5	-2.8	-1.9	-1.9
Hand grip strength (right)	0.3	0.8	2.2	1.5	0.8	-0.3	-0.1
Townsend deprivation index at recruitment	0.9	1.3	4.6	0.1	-2.1	-0.5	-0.5
Current tobacco smoking	2.7	4.4	8.1	0.6	1.0	-2.8	-2.8
Average weekly fortified wine intake	1.3	1.6	3.4	-0.0	-1.9	1.2	1.2
Maternal smoking around birth	1.8	2.6	4.8	0.9	-0.1	-2.2	-2.2
Fed-up feelings	4.0	7.2	13.7	0.5	1.6	-3.5	-3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.8	-0.7	0.8	-1.2	-1.3
Relative age voice broke	0.6	0.9	2.4	0.6	1.5	-0.7	-0.6
Taking other prescription medications	2.5	3.9	8.0	0.5	-0.0	-2.7	-2.8
Age when periods started (menarche)	0.1	0.2	0.6	0.8	-0.0	0.1	0.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.0	-0.2	-0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.3	-0.4	0.5	0.6	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	0.8	-0.3	-0.9	0.9	0.8
Qualifications: CSEs or equivalent	0.9	1.2	3.2	1.8	0.6	-0.8	-0.9
Serious illness, injury or assault to yourself	2.9	3.5	6.6	-2.6	-2.0	1.3	1.4
High blood pressure	1.2	3.4	6.7	1.2	-0.2	-2.6	-2.3
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	-0.3	0.1	-0.0	-0.4
Multivitamins +/- minerals	2.0	2.6	4.6	0.7	-0.8	-2.1	-2.1
Stomach or abdominal pain in last month	1.9	2.3	4.6	-0.5	0.4	-2.1	-2.1
Supplements: Glucosamine	0.5	0.6	1.4	-0.8	-1.2	0.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.7	-0.8	0.4	-0.7	-0.6
Medication: Atenolol	0.8	1.0	1.7	1.3	-0.5	-1.1	-1.0
Medication: Levothyroxine sodium	3.9	6.6	12.7	1.4	-0.0	-3.6	-3.5
Sitting height	0.4	2.9	3.8	-1.5	-1.4	1.9	1.9
Chronic bronchitis/emphysema (father)	0.5	0.5	1.1	1.1	-0.9	-0.3	-0.3
High blood pressure (mother)	1.9	2.6	4.1	1.4	0.5	-2.0	-2.0
Body mass index (BMI)	1.2	4.9	9.6	-2.0	-3.1	-1.7	-1.7
Impedance of leg (left)	0.3	1.2	3.2	1.1	1.8	-0.6	-0.5
Leg predicted mass (left)	0.7	3.6	7.7	-2.5	-2.8	0.7	0.6
Trunk fat mass	1.2	5.4	10.1	-2.8	-3.2	-1.3	-1.4
Waist circumference	1.5	5.5	12.2	-3.0	-3.5	-0.6	-0.7
Number of incorrect matches in round	4.9	8.2	14.4	1.3	1.6	-3.8	-3.8
Past tobacco smoking	6.4	11.7	19.6	-2.4	-1.5	4.4	4.4
Alcohol usually taken with meals	0.5	0.9	1.9	0.7	-1.4	0.8	0.7
Nervous feelings	0.3	0.5	1.4	-1.2	-0.1	0.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.7	1.1	0.2	-1.5	-1.6
Hearing difficulty/problems with background noise	0.9	1.5	4.4	-1.0	-2.1	-0.3	-0.6
Hair/balding pattern: Pattern 2	1.0	1.2	4.3	0.5	2.1	0.3	0.6
Had menopause	0.1	0.1	0.4	0.2	-0.7	-0.2	-0.2
Had other major operations	2.4	2.9	6.2	-0.4	-0.3	-2.3	-2.5
Forced vital capacity (FVC)	0.6	2.2	3.1	-1.4	-0.8	1.7	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.7	-0.8	0.8	0.7	0.5
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.5	-1.2	-0.1	-1.4	-1.6
Qualifications: None of the above	7.0	15.0	20.7	4.4	1.6	-4.5	-4.2
Financial difficulties in last 2 years	3.9	5.3	8.8	1.4	1.2	-2.9	-3.0
Mouth/teeth dental problems	1.5	2.4	4.2	0.1	1.1	2.0	2.0
Heart attack	1.1	1.4	2.4	1.6	0.8	-1.2	-1.1
Allergy	0.2	0.5	0.9	-0.4	-0.8	0.6	0.9
Pain all over the body in last month	1.7	1.9	2.0	1.3	1.4	-1.4	-1.4
Diabetes (self-reported)	0.9	1.4	1.9	-0.8	-1.4	-1.1	-1.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.7	0.5	1.0	-1.6	-1.6
Medication: Ramipril	2.7	3.4	6.7	0.1	-0.9	-2.6	-2.5
Medication: Simvastatin	1.6	2.4	4.5	0.7	-0.5	-2.1	-2.1
Fluid intelligence score	9.9	20.6	38.6	-1.6	-1.7	6.2	6.2
Illnesses of siblings	5.5	7.7	15.3	-0.7	0.5	3.8	3.9
Neuroticism score	2.5	5.2	8.2	-0.2	2.3	-2.7	-2.9
Weight	1.0	5.1	12.5	-2.8	-3.5	-0.4	-0.5
Impedance of arm (right)	0.0	0.2	0.4	-0.0	0.6	-0.2	-0.4
Arm fat percentage (right)	1.5	5.9	10.6	-2.2	-3.2	-2.0	-2.1
Trunk fat-free mass	0.7	3.9	5.6	-1.8	-2.4	1.8	1.8
Hip circumference	1.2	5.3	15.1	-2.3	-3.9	-0.7	-0.7
Time employed in main current job	0.7	0.8	1.7	1.0	-1.3	0.4	0.6
Alcohol intake versus 10 years previously	0.7	1.0	2.1	0.2	0.2	-1.4	-1.4
Father’s age at death	2.6	3.5	6.0	-1.5	-0.1	2.4	2.4
Worrier / anxious feelings	2.1	3.9	6.0	0.3	2.3	-2.1	-2.4
Frequency of tiredness / lethargy in last 2 weeks	5.1	8.3	10.9	2.1	2.7	-3.2	-3.3
Falls in the last year	1.9	2.5	7.6	-0.9	-2.8	-0.8	-1.0
Hair/balding pattern: Pattern 3	0.6	0.9	1.4	1.2	-0.4	-0.9	-1.1
Number of live births	1.9	2.7	5.0	0.9	-0.8	-2.2	-2.1
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	4.7	-1.9	-0.5	2.2	2.2
Pulse rate	0.1	0.2	0.9	-0.9	0.2	0.1	0.1
Happiness	0.1	0.1	0.2	0.2	-0.2	0.4	0.3
Noisy workplace	0.0	0.0	0.1	-0.1	-0.3	-0.2	-0.2
Qualifications: A levels/AS levels or equivalent	7.6	16.8	30.1	-3.1	-0.8	5.5	5.2
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	-0.2	0.3	-0.0	-0.0
Mouth/teeth dental problems: Dentures	1.9	3.3	5.7	0.9	-1.2	-2.4	-2.3
Asthma	0.1	0.1	0.2	-0.5	0.1	-0.2	-0.5
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.7	7.5	-0.4	0.4	-2.6	-2.7
Medication: Cholesterol lowering	0.6	1.0	1.6	0.9	0.0	-1.3	-1.2
Depression (self-reported)	2.6	3.1	4.2	-1.0	2.0	-1.9	-1.9
Medication: Lansoprazole	5.2	5.9	8.3	2.2	1.5	-2.9	-2.9
Prospective memory result	6.0	7.4	10.1	1.6	2.6	-3.2	-3.2
Lung cancer (father)	0.8	0.9	1.6	0.5	-0.7	-1.3	-1.2
Illnesses of mother	0.1	0.2	0.3	-0.5	-0.5	0.3	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	3.5	-1.9	-0.8	1.6	1.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	0.3	0.7	0.3	0.3
Impedance of arm (left)	0.0	0.2	0.6	-0.2	0.7	0.0	-0.2
Arm fat mass (right)	1.4	5.7	12.9	-2.6	-3.6	-1.2	-1.3
Trunk predicted mass	0.6	3.5	5.0	-1.7	-2.2	1.8	1.7
Standing height	0.5	5.4	7.8	-2.1	-1.6	2.8	2.6
Length of working week for main job	0.2	0.2	0.5	0.5	-0.7	0.0	0.0
Exposure to tobacco smoke at home	0.4	0.5	1.0	1.0	0.7	-0.6	-0.4
Breastfed as a baby	0.9	1.1	1.9	0.5	0.5	1.4	1.4
Tense / ‘highly strung’	1.1	1.7	4.5	-2.1	0.7	1.1	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	3.9	6.5	-2.5	0.8	-1.9	-2.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.7	-0.6	0.3	0.3
Birth weight of first child	0.7	1.2	3.5	-1.9	0.3	0.7	0.9
Peak expiratory flow (PEF)	1.4	3.2	4.7	-1.9	-0.8	1.9	2.2
Pulse wave reflection index	0.8	0.9	1.8	1.3	0.3	0.9	1.0
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.0	-0.2	1.0	-0.2	-0.1
Loud music exposure frequency	0.1	0.1	0.3	0.2	-0.3	0.4	0.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	2.6	-1.3	-0.5	1.6	1.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.1	-1.8	-0.4	0.5	0.4
Blood clot in the leg (DVT)	1.0	1.3	2.0	-1.2	0.1	1.3	1.4
Medication: Paracetamol	1.9	3.1	5.4	1.3	0.7	-2.3	-2.2
Headache pain in last month	2.8	4.9	9.9	-3.1	-1.3	2.0	2.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.4	-0.2	-0.2	1.2	1.1
Glaucoma (self-reported)	2.0	2.3	3.7	1.6	1.9	-1.3	-1.2
Gout (self-reported)	1.9	2.5	3.9	1.7	0.2	-2.0	-1.9
Hypothyroidism/myxoedema (self-reported)	5.7	11.2	21.4	1.5	-0.3	-4.6	-4.6
Medication: Amlodipine	0.8	1.1	2.2	-0.1	0.4	-1.5	-1.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	-1.2	-0.1	0.7	0.5
Birth weight	0.5	1.0	1.4	-1.2	0.4	1.1	1.1
Chronic bronchitis/emphysema (mother)	2.0	2.3	4.2	1.1	0.4	-1.9	-2.0
High blood pressure (siblings)	5.3	7.7	14.9	1.0	0.4	-3.9	-3.9
Forced vital capacity (FVC), Best measure	0.5	1.9	2.7	-1.5	-0.6	1.6	1.6
Body fat percentage	1.4	5.4	7.1	-2.4	-2.7	-2.1	-2.1
Leg fat percentage (right)	1.1	3.9	5.0	-1.7	-1.8	-2.2	-2.2
Arm fat-free mass (right)	0.5	2.8	5.2	-2.3	-1.9	1.0	1.1
Exposure to tobacco smoke outside home	0.8	1.0	2.1	0.1	0.6	1.5	1.3
Comparative body size at age 10	0.4	1.1	2.0	-1.2	-1.4	-0.6	-0.6
Number of full brothers	0.7	0.8	1.3	1.0	0.2	-1.0	-1.1
Worry too long after embarrassment	0.3	0.5	1.4	-1.2	0.0	-0.5	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.2	0.1	-0.0	-0.3
Wheeze or whistling in the chest in last year	0.5	1.0	1.9	0.5	-0.2	-1.4	-1.3
Number of children fathered	1.5	1.6	3.3	0.3	0.1	-1.8	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	2.5	3.0	5.5	1.1	-0.2	-2.4	-2.3
Age at first live birth	4.1	7.3	13.2	-0.7	1.8	3.5	3.6
Pulse wave peak to peak time	0.1	0.2	0.5	-0.3	-0.7	-0.2	-0.2
Health satisfaction	3.5	4.6	9.2	-0.1	-0.6	-2.9	-3.0
Shortness of breath walking on level ground	1.3	1.6	3.2	0.3	0.1	-1.8	-1.7
Qualifications: College or University degree	12.8	40.2	71.4	-4.3	-2.1	8.4	8.2
Eye problems/disorders: None of the above	1.1	1.3	2.6	-0.4	-0.4	1.6	1.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.8	0.7	-0.9	-0.7	-0.7
Emphysema/chronic bronchitis	0.5	0.5	1.9	1.4	-0.2	-0.3	-0.3
Medication for pain relief, constipation, heartburn	4.0	6.8	12.4	-1.6	-0.1	3.5	3.5
Neck or shoulder pain in last month	1.0	1.4	2.8	-0.1	-0.6	-1.7	-1.6
Medication: Blood pressure	0.0	0.1	0.1	-0.1	0.4	-0.4	-0.2
Angina (self-reported)	0.7	1.0	1.1	1.0	-1.0	-0.9	-1.0
Migraine (self-reported)	1.3	1.6	3.3	-1.8	0.7	1.0	1.3
Medication: Ibuprofen	1.3	1.5	2.5	-1.1	0.4	-1.4	-1.6
Medication: Allopurinol	2.6	3.5	6.0	1.3	0.6	-2.5	-2.4
Medication: Omeprazole	5.5	6.6	11.9	1.8	-0.6	-3.3	-3.5
Medication: Seretide 50 evohaler	0.4	0.5	1.3	-1.1	0.7	-0.3	-0.2
Mean time to correctly identify matches	2.4	4.6	9.4	0.8	0.3	-2.8	-3.1
Heart disease (mother)	0.4	0.5	0.9	-0.9	-0.3	0.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	-0.2	-0.0	-0.3	-0.3
Whole body fat mass	1.3	5.4	9.6	-2.7	-3.1	-1.4	-1.5
Leg fat mass (right)	1.1	4.4	7.6	-2.5	-2.8	-1.4	-1.4
Arm predicted mass (right)	0.7	3.5	5.7	-2.3	-2.4	1.2	1.2
Pulse rate, automated reading	0.3	0.9	2.7	-1.6	0.9	-0.2	-0.4
Alcohol intake frequency.	0.9	2.2	5.2	-1.5	-2.3	-0.8	-0.9
Comparative height size at age 10	0.6	3.5	4.7	-1.2	-1.9	2.1	2.2
Number of full sisters	1.3	1.6	2.4	1.0	-1.2	-1.3	-1.5
Suffer from ‘nerves’	0.3	0.4	1.5	-0.3	1.2	-0.1	-0.1
Overall health rating	5.3	11.3	21.6	1.5	0.3	-4.6	-4.6
Chest pain or discomfort	0.8	1.1	4.0	-0.5	-2.0	0.2	0.2
Had major operations	3.0	3.5	6.9	0.2	0.5	-2.6	-2.6
Age at last live birth	3.6	5.3	10.4	-0.4	0.7	3.2	3.2
Family relationship satisfaction	2.6	3.2	4.8	-1.2	-2.2	1.9	1.7
Leg pain on walking	1.8	2.2	3.7	1.2	0.9	-1.9	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.8	-0.3	-0.2	-1.4	-1.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.7	-0.7	0.1	0.8	0.9
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.3	-0.9	-0.3	1.5	1.4
Medication: Aspirin	1.4	1.8	5.6	2.4	1.1	-0.5	-0.4
Supplements: Vitamin C	1.5	1.8	3.8	-0.4	0.5	-1.7	-2.0
Knee pain experienced in last month	0.4	0.5	2.1	-0.0	-1.5	-0.0	-0.2
Hypertension (Self-reported)	1.2	3.2	6.4	0.9	-0.4	-2.5	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.1	6.0	9.3	2.3	0.7	-3.0	-3.1
Illnesses of father: Heart disease	1.3	1.8	3.3	-1.8	-1.6	0.8	0.9
Illnesses of siblings: Diabetes	0.9	1.1	1.7	-0.8	-0.6	-1.2	-1.3
Smoking status: Previous	5.6	8.4	14.0	2.0	1.5	-3.7	-3.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.3	-0.2	-0.2	1.5	1.2
Whole body fat-free mass	0.6	3.4	6.3	-2.0	-2.5	1.3	1.2
Leg fat-free mass (right)	0.7	3.8	8.2	-2.5	-2.9	0.7	0.6
Arm fat percentage (left)	1.4	5.8	10.0	-2.3	-3.2	-1.9	-2.0
Average weekly red wine intake	2.1	3.1	4.2	2.0	0.8	-1.9	-2.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.7	-0.0	1.3	0.5	0.6
Mood swings	2.3	4.2	7.1	0.2	1.6	-2.6	-2.7
Loneliness, isolation	1.1	1.5	3.5	-1.9	-1.3	-0.6	-0.7
Long-standing illness, disability or infirmity	0.6	0.9	2.4	-1.6	-1.1	0.1	-0.0
Ever had bowel cancer screening	0.2	0.2	0.6	-0.8	-0.6	-0.0	-0.1
Diabetes diagnosed by doctor	0.9	1.5	2.0	-1.4	-1.4	-0.9	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.4	5.1	-2.3	-1.1	1.3	1.1
Friendships satisfaction	3.7	4.5	8.3	-1.4	-0.7	2.9	2.7
Qualifications: nursing, teaching	4.7	7.3	12.3	-1.5	-1.8	3.5	3.4
Commuting to job workplace: Walk	0.9	1.0	1.9	0.8	-0.3	1.4	1.2
Eye problems/disorders: Cataract	0.4	0.5	0.8	0.9	0.1	-0.7	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	5.2	0.5	0.3	-2.1	-2.3
Medication for cholesterol	5.6	8.5	14.8	-1.8	1.1	3.8	3.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.9	4.6	7.4	0.8	1.7	-2.7	-2.7
Back pain experienced in last month	1.9	2.7	4.5	1.1	-1.1	-2.1	-2.0
Mineral and other dietary supplements	2.4	3.3	6.4	-1.0	0.2	2.5	2.4
Breast cancer (self-reported)	1.8	2.1	4.0	-0.4	0.7	2.0	2.0
Asthma (self-reported)	0.0	0.1	0.2	-0.4	0.2	0.0	-0.3
Osteoporosis (self-reported)	0.3	0.3	0.8	0.9	0.0	0.5	0.5
Osteoarthritis (self-reported)	0.1	0.2	0.6	-0.2	-0.8	-0.1	-0.2
Medication: Aspirin	1.0	1.3	4.0	2.0	1.0	-0.2	-0.2
Medication: Gliclazide	0.6	0.7	1.4	0.6	-0.3	-1.1	-1.2
Illnesses of father: None of the above (group 1)	0.6	0.7	1.4	1.2	1.2	-0.3	0.0
Smoking status: Current	2.9	4.6	8.6	0.9	0.9	-2.9	-2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	4.1	-0.9	-1.2	2.0	1.9
Whole body water mass	0.6	3.4	6.2	-2.0	-2.5	1.3	1.3
Leg predicted mass (right)	0.7	3.8	8.1	-2.5	-2.9	0.7	0.6
Arm fat mass (left)	1.4	5.7	13.1	-2.6	-3.6	-1.2	-1.3
Number of self-reported non-cancer illnesses	2.6	4.6	8.1	-0.5	-1.4	-2.8	-2.9
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.7	-0.5	-0.1	-0.4
Miserableness	5.5	9.5	18.0	-0.1	1.8	-4.1	-4.2
Guilty feelings	2.0	2.9	6.0	0.7	0.8	-2.1	-2.5
Wears glasses or contact lenses	1.9	2.2	6.2	2.5	1.2	-1.0	-0.7
Ever taken oral contraceptive pill	0.4	0.4	1.4	-1.2	0.6	0.0	-0.1
Hearing aid user	1.5	1.7	4.7	-0.0	-2.2	-1.0	-1.1
Mother’s age at death	3.4	4.2	6.5	-1.4	-2.5	2.1	2.0
Financial situation satisfaction	2.2	2.7	4.6	1.1	0.6	-2.1	-2.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.6	-0.0	0.8	-0.1	-0.1
Commuting to job workplace: Public transport	1.3	1.5	2.7	-0.8	0.5	1.6	1.6
Eye problems/disorders: Glaucoma	5.6	6.6	9.6	2.2	1.8	-3.1	-3.0
Medication: Blood pressure	1.8	3.5	6.6	1.1	-0.5	-2.6	-2.4
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.8	0.7	-0.8	-0.9	-0.7
Supplements: Fish oil (including cod liver oil)	3.0	3.9	6.9	1.5	0.3	-2.6	-2.5
High cholesterol (Self-reported)	1.8	3.2	5.5	1.5	-0.2	-2.3	-2.2
Medication: Bendroflumethiazide	0.2	0.4	0.8	-0.2	-0.3	-0.9	-0.7
Medication: Paracetamol	2.3	3.5	5.5	1.3	1.3	-2.3	-2.3
Medication: Lisinopril	1.0	1.3	2.6	0.3	0.3	-1.6	-1.6
Medication: Atorvastatin	0.2	0.3	0.6	-0.1	-0.8	-0.5	-0.5
Illnesses of father: High blood pressure	0.6	0.8	1.0	-0.6	0.8	-1.0	-1.0
Alcohol drinker status: Never	1.9	2.3	4.5	-1.6	-2.1	1.2	1.0
Ever smoked	3.7	6.4	10.4	1.9	1.3	-3.2	-3.2
Basal metabolic rate	0.7	3.9	8.5	-2.4	-2.9	0.9	0.9
Leg fat percentage (left)	1.2	4.4	5.6	-1.6	-2.0	-2.4	-2.3
Arm fat-free mass (left)	0.6	2.9	6.2	-2.0	-2.5	0.8	0.9
Number of operations (self-reported)	5.6	8.3	16.7	0.5	0.1	-4.0	-4.1
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.6	0.1	-0.7	-0.8
Irritability	0.8	1.3	2.3	-0.6	1.5	1.1	1.1
Risk taking	5.0	7.3	9.7	-2.9	-3.1	2.5	2.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.7	-0.4	-0.3	0.8	0.8
Fractured/broken bones in last 5 years	1.1	1.4	5.0	-2.2	-0.2	0.7	0.4
Age started oral contraceptive pill	3.0	3.8	5.4	-2.1	-0.6	2.3	2.3
Diastolic blood pressure, automated reading	0.7	2.3	4.3	0.4	0.7	-2.1	-2.1
Ever depressed for a whole week	0.3	0.4	0.9	-0.9	0.3	-0.5	-0.6
Unable to work because of sickness or disability	1.6	2.1	4.0	-0.6	-0.5	-2.0	-2.0
Commuting to job workplace: Cycle	1.9	2.3	4.8	-2.2	-0.5	1.5	1.3
Myopia	4.6	6.7	10.5	-1.7	-2.0	3.2	3.1
Vascular/heart problems diagnosed by doctor	1.4	3.7	7.0	-1.3	0.2	2.6	2.5
Cholesterol lowering medication	3.2	4.7	8.1	1.5	-0.9	-2.8	-2.9
Medication: Omeprazole (e.g. Zanprol)	5.2	6.4	11.5	1.8	-0.0	-3.3	-3.4
Pain experienced in last month	0.7	1.2	2.4	1.3	1.5	0.6	0.5
Supplements: Calcium	0.0	0.0	0.1	0.1	0.3	-0.1	-0.2
Basal cell carcinoma (self-reported)	2.1	2.5	4.2	-1.8	-2.0	1.2	1.1
Heart attack/myocardial infarction (self-reported)	1.2	1.5	2.3	1.5	0.5	-1.3	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	2.4	-1.0	0.3	1.5	1.6
Heart disease (siblings)	1.8	2.2	3.3	0.3	-1.8	-1.6	-1.7
Alcohol drinker status: Previous	0.2	0.2	0.5	0.4	-0.7	-0.5	-0.3
Pack years of smoking	0.2	0.3	0.9	-0.2	-1.0	-0.3	-0.2
Impedance of whole body	0.1	0.5	1.5	0.2	1.2	-0.4	-0.5
Leg fat mass (left)	1.2	4.6	8.0	-2.4	-2.8	-1.5	-1.5
Arm predicted mass (left)	0.7	3.4	7.3	-2.2	-2.7	0.9	0.9