TWAS hub - TMEM242

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.351	0.0839	1.0e-03	0.225	NA	0.173	NA	0.213	3.1e-12	NA	1.6e-09	NA	1.3e-11
2	GTEx	Muscle Skeletal	0.450	0.0473	7.8e-16	0.347	NA	0.360	NA	0.371	3.0e-35	NA	8.2e-37	NA	3.7e-38
3	ROSMAP	Brain Pre-frontal Cortex	0.258	0.0615	1.5e-05	0.224	0.105	0.222	0.222	0.224	2.3e-28	1.9e-13	4.6e-28	4.7e-28	2.2e-28

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Past tobacco smoking	10.6	19.4	29.2	-3.6	-4.0	-5.4
Smoking status: Previous	10.5	15.8	24.6	3.1	3.6	5.0
Ever smoked	8.5	14.9	19.9	3.4	3.6	4.5
Qualifications: nursing, teaching	7.8	12.2	18.6	4.3	4.0	1.5
Risk taking	5.4	7.9	13.0	1.8	2.7	3.6
Reason for reducing amount of alcohol drunk: Health precaution	4.3	5.0	6.1	-2.5	-2.3	-1.9
Hearing aid user	4.0	4.6	7.2	1.6	2.0	2.7
Smoking Status	3.5	8.3	16.5	1.8	2.3	4.1
HbA1C	3.3	3.7	5.5	-2.4	-2.4	0.0
Worrier / anxious feelings	3.3	6.2	7.1	-2.5	-2.7	-2.4
Lung cancer (father)	3.3	3.8	4.6	1.8	1.9	2.2
High cholesterol (Self-reported)	3.2	5.6	6.9	2.5	2.6	1.9
Vitamin and mineral supplements	3.1	4.2	5.4	2.3	2.0	1.7
Migraine (self-reported)	3.1	3.8	5.7	1.6	1.8	2.4
Serious illness, injury or assault to yourself	3.0	3.6	3.7	1.9	1.9	1.9
Medication: Cholesterol lowering	3.0	4.7	6.6	1.7	2.1	2.6
Handedness (chirality/laterality): Left-handed	2.8	3.3	7.0	-1.0	-1.4	-2.6
Pack years adult smoking proportion	2.6	4.0	5.5	-2.2	-2.3	-1.2
Heart disease (mother)	2.6	3.1	3.4	1.7	1.9	1.8
Fluid intelligence score	2.5	5.2	6.9	2.6	2.6	1.5
Had other major operations	2.4	2.9	3.3	1.7	1.8	1.6
Worry (Nagel 2018)	2.3	4.9	5.5	-1.9	-2.4	-2.3
Hand grip strength (left)	2.3	6.0	9.5	-3.1	-2.8	-0.7
Ever had bowel cancer screening	2.3	2.7	3.3	1.6	1.8	1.5
Commuting to job workplace: Walk	2.3	2.5	2.9	1.7	1.5	1.6
Pack years of smoking	2.3	3.4	4.9	-2.0	-2.2	-1.2
Verbal and Numeric Reasoning (VNR)	2.2	5.2	6.7	2.6	2.6	1.6
Frequency of depressed mood in last 2 weeks	2.2	3.1	4.0	2.0	2.0	1.2
Mineral and other dietary supplements	2.2	2.9	5.4	2.3	1.8	0.1
Alcohol usually taken with meals	2.1	3.3	5.3	2.3	2.1	0.6
Hair/balding pattern: Pattern 2	2.1	2.7	2.8	1.7	1.6	1.6
Medication for cholesterol, blood pressure or diabetes	2.1	3.6	7.3	-1.0	-1.5	-2.7
Number of self-reported non-cancer illnesses	2.1	3.6	5.7	2.4	2.1	0.9
Myopia	2.1	3.0	4.2	2.0	2.0	0.9
Medication: Amlodipine	2.0	2.8	7.4	-0.9	-0.2	2.7
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	3.3	-1.4	-1.2	-1.8
Prospective memory result	1.9	2.4	2.6	-1.4	-1.6	-1.6
Number of full sisters	1.9	2.3	4.5	0.9	1.2	2.1
Commuting to job workplace: Cycle	1.9	2.3	4.0	1.2	1.2	2.0
Depressed Affect (Nagel 2018)	1.8	3.8	6.2	-1.5	-1.7	-2.5
Pulse wave reflection index	1.8	2.2	3.1	1.4	1.8	1.2
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	4.6	2.1	1.9	-0.5
Osteoporosis (self-reported)	1.8	2.2	2.5	1.6	1.5	1.4
Unable to work because of sickness or disability	1.8	2.3	3.4	1.3	1.3	1.8
Qualifications: CSEs or equivalent	1.7	2.3	3.5	-1.9	-1.8	-0.5
Alcohol intake versus 10 years previously	1.6	2.4	4.0	1.1	1.4	2.0
Length of working week for main job	1.6	1.8	2.5	1.0	1.3	1.6
Breastfed as a baby	1.5	1.9	3.0	1.0	1.3	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	4.0	2.0	1.7	-0.1
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.6	-1.1	-1.2	-1.6
Number of children fathered	1.5	1.7	1.9	1.4	1.3	1.2
Long-standing illness, disability or infirmity	1.5	2.3	3.6	1.9	1.7	0.7
Friendships satisfaction	1.5	1.8	1.9	-1.3	-1.4	-1.4
Multivitamins +/- minerals	1.4	1.8	2.7	-1.6	-1.1	-1.2
Nervous feelings	1.4	2.6	4.6	-1.1	-1.4	-2.2
Exposure to tobacco smoke at home	1.4	1.6	4.6	-0.2	0.3	2.1
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.7	-1.0	-1.1	-1.6
Mouth/teeth dental problems	1.3	1.9	3.1	-1.8	-1.6	0.5
Mouth/teeth dental problems: Dentures	1.3	2.1	2.6	1.3	1.5	1.6
Illnesses of father: Heart disease	1.3	1.7	3.0	1.7	1.5	0.2
Eye problems/disorders: Glaucoma	1.3	1.5	1.7	-1.3	-1.3	-1.1
Neuroticism (Nagel 2018)	1.2	2.9	4.8	-1.1	-1.6	-2.2
Cardiovascular Disease	1.2	3.9	5.2	1.7	1.9	2.3
High blood pressure	1.2	3.3	5.8	1.4	1.5	2.4
Waist circumference	1.2	4.4	4.9	2.0	2.1	2.2
Qualifications: None of the above	1.2	2.6	4.4	-2.1	-1.8	-0.0
Hypothyroidism/myxoedema (self-reported)	1.2	2.2	2.7	-1.6	-1.6	-1.3
Medication: Seretide 50 evohaler	1.2	1.4	2.0	-1.0	-1.4	-1.1
Had major operations	1.2	1.4	1.8	1.3	1.4	0.8
Family relationship satisfaction	1.2	1.4	1.6	-1.1	-1.3	-1.2
Ever had prostate specific antigen (PSA) test	1.2	1.3	1.7	1.3	1.3	0.9
Intelligence (Savage-Jansen 2018)	1.1	3.3	4.9	2.1	2.2	0.9
Pain all over the body in last month	1.1	1.2	3.5	-0.1	-0.3	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.2	-1.5	-1.2	0.4
High blood pressure (siblings)	1.1	1.6	1.8	1.4	1.3	1.2
Chest pain or discomfort	1.1	1.6	1.8	1.3	1.2	1.3
Ever taken oral contraceptive pill	1.1	1.2	1.7	-1.3	-1.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.6	1.6	1.0	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	1.7	-1.3	-1.2	-1.1
Blood Platelet Count	1.0	11.1	13.7	3.0	3.2	3.7
Had menopause	1.0	1.2	2.0	1.4	1.1	-0.6
Illnesses of siblings	1.0	1.4	1.8	-1.4	-1.2	-0.9
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.3	1.8	1.7	0.6
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.1	-0.3	-0.9	-1.8
Number of full brothers	1.0	1.3	1.7	1.3	1.0	1.1
Age at first live birth	1.0	1.8	2.5	1.6	1.4	1.0
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.3	-1.5	-1.2	-0.2
Ever had hysterectomy (womb removed)	0.9	1.0	1.6	1.3	1.2	-0.1
Medication: Simvastatin	0.9	1.3	1.8	1.3	1.4	0.7
Medication: Blood pressure	0.9	1.6	4.0	0.4	0.9	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.8	-1.4	-1.1	0.3
Commuting to job workplace: Public transport	0.9	1.1	1.6	0.9	0.9	1.3
Lupus	0.8	1.2	3.5	0.0	0.0	-1.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.4	1.1	1.2	0.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.7	1.3	1.1	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	3.8	-1.2	-0.4	2.0
Stomach or abdominal pain in last month	0.8	1.0	2.3	0.6	0.5	1.5
Impedance of leg (left)	0.8	3.9	7.9	-1.1	-1.6	-2.8
Heart attack	0.8	1.0	1.3	1.2	1.0	0.7
Asthma	0.8	1.6	1.9	1.4	1.4	1.0
Blood clot in the leg (DVT)	0.8	1.1	1.5	-1.2	-1.0	-0.8
Glaucoma (self-reported)	0.8	1.0	1.4	-1.2	-1.0	-0.7
Neck or shoulder pain in last month	0.8	1.2	2.2	1.5	1.0	0.6
Hypertension (Self-reported)	0.8	2.1	4.5	0.9	1.1	2.1
Medication for cholesterol	0.8	1.2	1.7	-1.3	-1.1	0.8
Medication: Aspirin	0.8	1.1	2.4	0.6	0.7	1.5
Medication: Bendroflumethiazide	0.8	1.3	1.5	1.0	1.1	1.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	3.6	-1.2	-1.2	-1.9
Hearing difficulty/problems: Yes	0.7	1.1	1.3	1.1	1.1	0.8
Maternal smoking around birth	0.7	1.1	2.5	-0.7	-0.4	1.6
Age when periods started (menarche)	0.7	1.8	2.1	1.2	1.4	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.4	1.0	1.2	0.4
Arm fat mass (right)	0.7	3.0	4.0	1.5	1.7	2.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.9	1.4	1.2	0.2
Medication: Lisinopril	0.7	0.9	1.5	0.7	0.9	1.2
Medication: Atorvastatin	0.7	0.9	1.8	0.5	0.8	1.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.3	1.1	1.0	0.6
Impedance of whole body	0.7	3.7	9.3	-0.8	-1.1	-3.0
Neuroticism (2016)	0.6	0.8	1.2	-1.1	-1.1	0.0
Blood Eosinophil Count	0.6	5.0	6.2	2.3	2.5	1.8
BMI	0.6	3.4	5.3	1.5	1.6	2.3
Type 2 Diabetes (T2D) (2018)	0.6	1.2	1.3	1.1	1.0	1.1
Lung FEV1/FVC ratio	0.6	3.2	3.7	1.9	1.9	1.6
Neuroticism	0.6	1.3	3.1	-0.4	-0.8	-1.8
Medication: Co-codamol	0.6	0.7	0.9	-0.9	-1.0	-0.6
Diabetes (mother)	0.6	0.7	1.2	1.1	0.9	0.3
Impedance of leg (right)	0.6	3.1	7.2	-0.8	-1.3	-2.7
Hand grip strength (right)	0.6	1.6	2.0	-1.4	-1.2	1.2
Current tobacco smoking	0.6	0.9	1.8	-0.8	-0.6	1.4
Chronic bronchitis/emphysema (father)	0.6	0.7	0.9	0.9	0.9	0.7
Body mass index (BMI)	0.6	2.4	4.9	1.0	1.1	2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.8	-0.6	0.1	1.9
Arm fat percentage (right)	0.6	2.4	3.0	1.4	1.6	1.7
Number of live births	0.6	0.9	1.3	-1.1	-1.1	-0.5
Depression (self-reported)	0.6	0.7	1.9	-0.2	-0.3	-1.4
Illnesses of mother	0.6	0.8	1.2	-0.7	-0.8	-1.1
Impedance of arm (left)	0.6	2.8	7.3	-0.6	-0.7	-2.7
Tense / ‘highly strung’	0.6	1.1	2.7	-0.3	-0.6	-1.7
Gout (self-reported)	0.6	0.8	1.3	-1.1	-1.1	0.2
Angina (self-reported)	0.6	0.8	1.3	0.8	1.1	0.6
Comparative height size at age 10	0.6	3.1	3.9	-1.8	-2.0	-1.4
Smoking status: Current	0.6	1.0	1.7	-0.9	-0.7	1.3
Wears glasses or contact lenses	0.6	0.7	1.5	-0.0	-0.8	-1.2
Supplements: Calcium	0.6	0.7	1.2	-1.1	-1.0	-0.1
Alcohol drinker status: Previous	0.6	0.7	1.4	0.5	0.6	1.2
Blood White Count	0.5	3.5	8.3	0.7	1.2	2.9
Allergy or Eczema	0.5	1.4	2.5	1.6	0.9	-0.9
Angina	0.5	0.6	1.0	0.7	1.0	0.5
Medication: Metformin	0.5	0.8	0.8	0.9	0.9	0.9
Diabetes (father)	0.5	0.6	1.1	0.7	0.6	1.0
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.8	1.3	0.9	-0.7
Supplements: Glucosamine	0.5	0.7	1.1	-1.0	-0.9	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.6	1.2	0.9	0.1
Financial difficulties in last 2 years	0.5	0.7	0.8	0.8	0.8	0.9
Impedance of arm (right)	0.5	2.2	5.9	-0.5	-0.6	-2.4
Happiness	0.5	0.6	0.9	-0.9	-0.9	0.3
Loud music exposure frequency	0.5	0.5	1.4	-0.5	-0.2	1.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.0	-0.1	-0.2	-1.4
Forced vital capacity (FVC), Best measure	0.5	2.0	3.2	-1.8	-1.7	-0.1
Leg fat percentage (right)	0.5	1.8	1.9	1.3	1.3	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	0.4	0.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.3	1.1	1.0	1.0
Arm fat percentage (left)	0.5	1.9	2.2	1.2	1.4	1.5
Illnesses of father: None of the above (group 1)	0.5	0.6	0.8	-0.9	-0.7	-0.8
Arm fat mass (left)	0.5	1.9	3.0	1.1	1.2	1.7
Illnesses of father: High blood pressure	0.5	0.6	1.1	0.6	0.6	1.1
Waist Hip Ratio (WHR)	0.4	1.7	2.3	1.5	1.5	0.7
Fed-up feelings	0.4	0.7	0.8	-0.9	-0.8	-0.7
Relative age voice broke	0.4	0.6	0.8	0.9	0.7	-0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.5	0.7	0.7	0.5
Medication: Atenolol	0.4	0.5	0.8	0.6	0.9	0.5
Medication: Levothyroxine sodium	0.4	0.7	1.5	-0.6	-0.6	-1.2
High blood pressure (mother)	0.4	0.6	0.7	0.8	0.7	0.7
Forced vital capacity (FVC)	0.4	1.7	3.1	-1.8	-1.4	0.4
Falls in the last year	0.4	0.5	1.0	0.3	0.6	1.0
Peak expiratory flow (PEF)	0.4	1.0	2.4	-0.6	-0.4	1.6
Birth weight	0.4	0.9	1.1	0.8	1.1	0.9
Worry too long after embarrassment	0.4	0.6	1.2	-0.4	-0.8	-1.1
Shortness of breath walking on level ground	0.4	0.5	1.0	0.5	0.4	1.0
Medication: Omeprazole	0.4	0.5	1.1	1.1	0.5	-0.4
Leg fat mass (right)	0.4	1.7	2.7	1.1	1.1	1.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.8	0.8	0.9	-0.0
Medication: Aspirin	0.4	0.5	1.3	0.3	0.5	1.1
Loneliness, isolation	0.4	0.6	0.9	-0.7	-0.7	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.6	0.8	0.8	0.6
Average weekly beer plus cider intake	0.4	0.6	1.9	0.1	0.1	1.4
Diastolic blood pressure, automated reading	0.4	1.2	2.6	0.6	0.7	1.6
Leg fat mass (left)	0.4	1.4	2.3	1.0	1.0	1.5
Depression (Nagel 2018)	0.3	0.5	0.9	0.7	0.5	-0.9
Alzheimer’s Disease (in mother)	0.3	0.3	0.4	0.6	0.6	0.3
Alzheimer’s Disease (in father)	0.3	0.3	0.4	-0.4	-0.5	-0.6
Lung FVC	0.3	1.6	3.0	-1.3	-0.5	1.7
Tanning	0.3	3.4	9.1	0.1	1.1	3.0
Neuroticism score	0.3	0.6	1.0	-0.5	-0.8	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.3	-1.1	-1.0	0.4
Health satisfaction	0.3	0.4	1.2	0.1	0.2	1.1
Eye problems/disorders: None of the above	0.3	0.3	0.9	-0.0	-0.0	-0.9
Emphysema/chronic bronchitis	0.3	0.4	1.0	0.3	0.2	1.0
Whole body fat mass	0.3	1.2	1.4	1.0	1.0	1.2
Suffer from ‘nerves’	0.3	0.5	0.7	-0.8	-0.8	-0.5
Overall health rating	0.3	0.6	0.8	-0.5	-0.9	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.6	-0.2	-0.7	-0.8
Illnesses of siblings: Diabetes	0.3	0.3	0.6	0.8	0.7	0.1
Average weekly red wine intake	0.3	0.4	1.1	-0.1	-0.4	-1.1
Diabetes diagnosed by doctor	0.3	0.5	0.7	0.8	0.6	0.7
Breast cancer (self-reported)	0.3	0.3	0.4	0.5	0.6	0.7
Asthma (self-reported)	0.3	0.7	1.0	1.0	0.8	0.6
Medication: Gliclazide	0.3	0.4	0.7	-0.6	-0.1	0.8
Miserableness	0.3	0.5	0.6	-0.6	-0.7	-0.8
Guilty feelings	0.3	0.4	0.7	0.3	0.6	0.9
Mother’s age at death	0.3	0.3	0.5	0.7	0.4	-0.5
Financial situation satisfaction	0.3	0.4	0.6	-0.3	-0.8	-0.7
Medication: Blood pressure	0.3	0.5	0.6	0.8	0.8	0.5
Leg fat percentage (left)	0.3	1.2	1.4	1.1	1.0	1.2
Number of operations (self-reported)	0.3	0.5	0.6	0.6	0.6	0.8
Age started oral contraceptive pill	0.3	0.4	0.7	0.6	0.4	-0.8
Cholesterol lowering medication	0.3	0.4	1.1	0.2	-0.1	-1.0
Crohns Disease (2017)	0.2	0.3	0.7	-0.8	-0.5	-0.3
Irritable Bowel Disease (IBD)	0.2	0.4	0.7	-0.8	-0.6	-0.4
Hypothyroidism (self reported)	0.2	0.4	0.7	-0.5	-0.5	-0.8
Average weekly spirits intake	0.2	0.2	0.3	-0.5	-0.5	-0.4
Relative age of first facial hair	0.2	0.5	0.7	0.7	0.4	-0.9
Systolic blood pressure, automated reading	0.2	0.6	1.0	0.9	0.3	-1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.4	-0.4	0.5
Severe depression (siblings)	0.2	0.2	0.2	0.4	0.4	-0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.2	0.0	0.7
Trunk fat mass	0.2	0.9	1.0	1.0	1.0	0.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	0.0	-0.3	-0.8
Hip circumference	0.2	0.7	1.6	0.3	0.5	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.6	0.8	0.7	0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.1	0.1	-0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.3	-0.7	-0.3	1.1
Medication: Lansoprazole	0.2	0.3	0.6	0.4	-0.0	-0.8
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	0.2	0.3	0.7
Headache pain in last month	0.2	0.4	0.6	0.8	0.6	-0.3
Body fat percentage	0.2	0.9	1.0	0.9	1.0	0.9
Comparative body size at age 10	0.2	0.5	0.5	-0.7	-0.7	-0.6
Medication: Ibuprofen	0.2	0.2	0.4	0.6	0.7	-0.0
Medication: Allopurinol	0.2	0.3	0.5	-0.6	-0.7	0.0
Pulse rate, automated reading	0.2	0.6	1.8	-0.1	-0.2	1.4
Alcohol intake frequency.	0.2	0.5	0.8	0.9	0.8	0.1
Age at last live birth	0.2	0.3	0.4	-0.5	-0.6	-0.6
Mood swings	0.2	0.4	0.7	-0.5	-0.6	-0.9
Osteoarthritis (self-reported)	0.2	0.2	0.4	0.5	0.7	0.1
Average weekly champagne plus white wine intake	0.2	0.2	0.4	0.6	0.5	0.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	0.5	0.1	-0.5
Heart disease (siblings)	0.2	0.2	0.4	-0.6	-0.5	0.1
Arm predicted mass (left)	0.2	0.8	2.0	0.5	0.4	1.4
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.6	-0.5	-0.2
Reaction Time	0.1	0.3	0.4	-0.3	-0.5	-0.7
Breast Cancer	0.1	0.1	0.2	0.4	0.5	0.1
Ovarian Cancer	0.1	0.2	0.3	0.5	0.4	-0.3
Fasting Glucose	0.1	0.1	0.2	-0.4	0.2	0.0
Blood Red Count	0.1	0.8	2.2	-0.1	-0.4	-1.5
Heel T-Score	0.1	1.2	3.2	-0.5	0.3	1.8
Sensitivity / hurt feelings	0.1	0.2	0.5	0.7	0.3	-0.4
Medication for hormone replacement therapy	0.1	0.1	0.2	0.1	0.3	-0.4
Leg fat-free mass (left)	0.1	0.6	1.6	0.1	0.4	1.2
Trunk fat percentage	0.1	0.5	0.7	0.7	0.8	0.6
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.4	-0.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.2	0.1	-0.6
Taking other prescription medications	0.1	0.1	0.3	0.4	0.1	-0.5
Leg predicted mass (left)	0.1	0.6	1.6	0.1	0.4	1.3
Number of incorrect matches in round	0.1	0.2	0.5	-0.0	-0.1	0.7
Allergy	0.1	0.2	0.5	-0.7	-0.4	0.3
Diabetes (self-reported)	0.1	0.1	0.2	0.3	0.1	0.4
Weight	0.1	0.7	1.5	0.6	0.6	1.2
Time employed in main current job	0.1	0.1	0.2	0.5	0.2	0.4
Father’s age at death	0.1	0.2	0.3	0.6	0.2	-0.3
Pulse rate	0.1	0.1	0.2	-0.4	-0.5	0.3
Noisy workplace	0.1	0.2	0.3	0.2	0.4	0.5
Standing height	0.1	1.2	2.5	-0.6	-0.9	-1.6
Hair/balding pattern: Pattern 4	0.1	0.3	0.4	-0.6	-0.5	-0.4
Birth weight of first child	0.1	0.1	0.2	0.3	0.4	0.1
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	-0.0	-0.3	-0.6
Medication: Paracetamol	0.1	0.2	0.5	0.2	0.3	0.7
Arm fat-free mass (right)	0.1	0.5	1.3	0.2	0.2	1.1
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.4	0.3	-0.2
Pulse wave peak to peak time	0.1	0.2	0.5	-0.0	-0.2	-0.7
Qualifications: College or University degree	0.1	0.3	0.6	0.6	0.2	-0.8
Mean time to correctly identify matches	0.1	0.1	0.2	0.4	0.3	-0.3
Arm predicted mass (right)	0.1	0.5	1.2	0.4	0.4	1.1
Supplements: Vitamin C	0.1	0.1	0.2	0.2	0.2	-0.4
Knee pain experienced in last month	0.1	0.2	0.3	-0.5	-0.4	-0.2
Whole body fat-free mass	0.1	0.3	0.9	-0.0	0.1	0.9
Leg fat-free mass (right)	0.1	0.5	1.3	-0.1	0.1	1.2
Back pain experienced in last month	0.1	0.1	0.2	0.4	0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	-0.1	0.2	0.8
Whole body water mass	0.1	0.4	1.2	0.1	0.2	1.1
Leg predicted mass (right)	0.1	0.5	1.5	-0.1	0.2	1.2
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.2	0.3	0.4	0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.4	-0.1	-0.2	-0.7
Medication: Paracetamol	0.1	0.2	0.3	0.5	0.5	0.4
Alcohol drinker status: Never	0.1	0.2	0.4	-0.2	-0.3	0.6
Basal metabolic rate	0.1	0.4	1.1	0.0	0.1	1.1
Arm fat-free mass (left)	0.1	0.7	1.9	0.4	0.4	1.4
Ever depressed for a whole week	0.1	0.1	0.2	-0.5	-0.4	0.2
Pain experienced in last month	0.1	0.2	0.3	0.4	0.6	0.5
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2018)	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.3	0.2	-0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.1	0.3	-0.2	-0.2	-0.5
Systolic Blood Pressure	0.0	0.0	0.1	0.3	-0.0	-0.2
Respiratory disease	0.0	0.0	0.1	0.3	0.1	0.2
Chronotype (morning person)	0.0	0.1	0.2	-0.2	-0.0	0.4
Hair Pigment	0.0	0.4	1.0	-0.0	-0.2	-1.0
Number of treatments/medications taken	0.0	0.1	0.1	0.3	0.1	-0.3
Supplements: Zinc	0.0	0.1	0.1	0.2	-0.1	-0.3
Average weekly fortified wine intake	0.0	0.0	0.1	-0.1	0.0	0.3
Sitting height	0.0	0.1	0.2	-0.4	-0.4	-0.3
Hearing difficulty/problems with background noise	0.0	0.0	0.0	0.1	0.2	0.2
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.0	-0.1	-0.0	0.1
Medication: Ramipril	0.0	0.0	0.1	-0.1	-0.2	-0.3
Trunk fat-free mass	0.0	0.2	0.5	0.1	0.0	0.7
Trunk predicted mass	0.0	0.2	0.6	0.2	0.1	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.2	0.1	0.3
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	-0.1	-0.3	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.1	0.1	-0.0
Medication for pain relief, constipation, heartburn	0.0	0.0	0.0	-0.2	-0.1	-0.2
Leg pain on walking	0.0	0.1	0.1	0.0	0.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	-0.2	-0.2	-0.1
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.1	0.1	0.3
Irritability	0.0	0.1	0.2	-0.2	-0.4	0.0
Fractured/broken bones in last 5 years	0.0	0.0	0.1	0.2	-0.3	0.0

Hub : Genes

TMEM242

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Trait associations