Hub : Traits :

Past tobacco smoking

119 significantly associated models · 51 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 44448632 45864710 1 1 4.3e-12 1.0e-11 1.0e+00 100 RP11-89K21.1
2 2 47224927 48727280 1 1 2.4e-07 8.6e-07 1.8e-02 77 MSH6
3 3 49634594 51032607 1 1 1.9e-07 9.2e-06 3.2e-01 95 NAT6
4 3 84317575 86808226 1 1 3.3e-11 2.1e-17 5.4e-08 59 CADM2
5 4 57080198 58531645 2 1 3.1e-08 2.3e-08 9.7e-02 91 REST
6 5 86867897 88427942 1 1 1.1e-07 5.0e-07 3.8e-01 97 TMEM161B-AS1
7 6 36751245 38162310 1 1 1.1e-07 1.3e-07 2.0e-02 80 CCDC167
8 6 110588546 112621834 4 3 1.3e-15 9.0e-18 3.4e-01 99 C6orf3 GTF3C6 RP5-1112D6.4
9 6 157013426 158435623 1 1 6.4e-08 6.8e-08 1.0e+00 100 TMEM242
10 7 2646223 5003373 1 1 4.5e-10 4.6e-11 2.7e-02 89 SDK1
11 7 98341025 99751521 1 1 9.3e-08 5.4e-07 7.1e-01 100 CPSF4
12 9 127218258 128824378 2 1 6.6e-08 2.2e-07 9.4e-03 75 PRPS1P2
13 10 103527782 105897979 15 4 2.3e-14 4.3e-13 7.5e-01 100 ACTR1A ARL3 RP11-332O19.5 TMEM180
14 11 112135760 113846006 1 1 4.7e-09 5.1e-36 1.2e-28 21 NCAM1
15 12 55746910 57125879 1 1 3.8e-07 4.0e-05 5.1e-02 78 RPS26
16 12 111193499 113137832 5 1 3.2e-08 2.1e-11 1.7e-05 59 ATXN2
17 15 51364940 52806425 1 1 3.3e-07 3.5e-06 6.4e-01 99 TMOD2
18 15 66850204 68789191 3 1 8.4e-09 2.6e-08 7.0e-02 89 MAP2K5
19 16 30347731 31720486 1 1 2.1e-07 7.6e-05 5.5e-03 51 STX1B
20 16 69062879 70473934 2 1 4.8e-10 2.7e-09 6.1e-01 99 NOB1
21 17 1517914 2918626 1 1 1.4e-07 5.2e-07 1.0e+00 100 SRR
22 18 20393480 21863589 1 1 9.9e-11 3.2e-07 1.7e-01 93 NPC1
23 20 30591354 32029439 1 1 2.9e-07 1.5e-06 1.9e-04 40 COMMD7

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Irritable Bowel Disease (IBD) 1.43 1 0 0.0 0.00 1.0e+00 C6orf3
Ulcerative Colitis (UC) 2.02 3 1 3.0 0.00 1.0e+00 C6orf3 CADM2 NAT6
Reaction Time 2.71 2 1 3.0 0.00 1.0e+00 ATXN2 COMMD7
Age at First Birth 1.81 1 0 0.0 0.00 1.0e+00 NAT6
Body Mass Index (BMI) (2010) 3.01 2 1 3.0 0.00 1.0e+00 MAP2K5 NPC1
Coronary Artery Disease (CAD) 1.60 1 0 0.0 0.00 1.0e+00 ATXN2
HbA1C 1.42 1 0 0.0 0.00 1.0e+00 ATXN2
LDL Cholesterol 1.03 1 1 3.0 0.00 1.0e+00 ATXN2
Lupus 1.63 2 0 0.0 0.00 1.0e+00 ATXN2 STX1B
Primary Biliary Cirrhosis 1.36 1 0 0.0 0.00 1.0e+00 ATXN2
Schizophrenia 1.87 4 1 3.0 -0.26 7.4e-01 ACTR1A ARL3 RP11-332O19.5 TMEM161B-AS1
Ulcerative Colitis 2.08 2 0 0.0 0.00 1.0e+00 C6orf3 COMMD7
Blood Eosinophil Count 4.89 5 3 9.1 0.36 5.5e-01 ATXN2 NAT6 REST RPS26 TMEM180
Blood Platelet Count 1.12 12 4 12.1 0.38 2.2e-01 ARL3 ATXN2 COMMD7 CPSF4 MSH6 NOB1 REST RP11-332O19.5 STX1B TMEM161B-AS1 TMEM180 TMEM242
Blood Red Count 1.59 8 4 12.1 -0.22 6.0e-01 ATXN2 COMMD7 GTF3C6 MAP2K5 NAT6 RP5-1112D6.4 RPS26 STX1B
Blood White Count 3.49 7 5 15.2 0.75 5.0e-02 ACTR1A ARL3 ATXN2 CPSF4 REST RP11-332O19.5 SRR
Heel T-Score 1.39 7 2 6.1 -0.05 9.1e-01 ACTR1A ARL3 MSH6 NCAM1 NOB1 REST SRR
BMI 3.71 12 6 18.2 0.42 1.7e-01 ACTR1A CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NOB1 NPC1 SRR STX1B TMEM161B-AS1 TMOD2
Height 0.75 14 3 9.1 0.26 3.6e-01 ACTR1A ATXN2 C6orf3 CCDC167 CPSF4 NAT6 NCAM1 NOB1 PRPS1P2 REST RP11-332O19.5 RPS26 SRR TMEM180
Waist Hip Ratio (WHR) 1.17 3 0 0.0 0.00 1.0e+00 MSH6 NAT6 PRPS1P2
Systolic Blood Pressure 2.91 7 4 12.1 -0.23 6.2e-01 ACTR1A ARL3 ATXN2 CADM2 NCAM1 NOB1 SRR
Smoking Status 15.35 26 19 57.6 0.98 1.2e-18 ACTR1A ARL3 ATXN2 C6orf3 CADM2 CCDC167 COMMD7 CPSF4 GTF3C6 MAP2K5 MSH6 NAT6 NCAM1 NOB1 PRPS1P2 REST RP11-332O19.5 RP11-89K21.1 RP5-1112D6.4 RPS26 SDK1 SRR STX1B TMEM161B-AS1 TMEM242 TMOD2
Allergy or Eczema 2.32 5 0 0.0 -0.64 2.4e-01 ARL3 ATXN2 CPSF4 RP11-332O19.5 SRR
Cardiovascular Disease 2.42 4 3 9.1 0.61 3.9e-01 ARL3 ATXN2 MAP2K5 TMEM161B-AS1
Hypothyroidism (self reported) 3.10 1 1 3.0 0.00 1.0e+00 ATXN2
Respiratory disease 1.28 1 0 0.0 0.00 1.0e+00 REST
Type 2 Diabetes (T2D) 1.58 2 0 0.0 0.00 1.0e+00 ATXN2 CPSF4
Lung FEV1/FVC ratio 1.43 6 2 6.1 0.38 4.5e-01 ACTR1A COMMD7 MSH6 REST RP11-332O19.5 TMEM180
Lung FVC 1.84 8 4 12.1 0.03 9.4e-01 C6orf3 MAP2K5 MSH6 NOB1 PRPS1P2 REST RPS26 STX1B
Neuroticism 2.06 3 0 0.0 0.00 1.0e+00 CADM2 MAP2K5 PRPS1P2
Chronotype (morning person) 2.58 6 0 0.0 -0.23 6.6e-01 ARL3 ATXN2 CPSF4 NCAM1 TMEM161B-AS1 TMEM180
Hair Pigment 0.14 3 0 0.0 0.00 1.0e+00 ATXN2 MSH6 REST
Tanning 0.50 4 1 3.0 0.20 8.0e-01 ATXN2 CADM2 COMMD7 RP11-332O19.5
Hand grip strength (left) 2.91 5 2 6.1 -0.52 3.7e-01 ACTR1A CADM2 NOB1 PRPS1P2 RP11-332O19.5
Number of treatments/medications taken 1.80 2 1 3.0 0.00 1.0e+00 ATXN2 COMMD7
Sensitivity / hurt feelings 0.94 1 0 0.0 0.00 1.0e+00 PRPS1P2
Hearing difficulty/problems: Yes 1.69 1 0 0.0 0.00 1.0e+00 REST
Relative age of first facial hair 1.46 1 0 0.0 0.00 1.0e+00 NAT6
Systolic blood pressure, automated reading 2.39 3 3 9.1 0.00 1.0e+00 ARL3 ATXN2 SRR
Angina 1.40 1 0 0.0 0.00 1.0e+00 NOB1
Medication for hormone replacement therapy 1.49 1 0 0.0 0.00 1.0e+00 RP5-1112D6.4
Pack years adult smoking proportion 2.16 1 0 0.0 0.00 1.0e+00 ARL3
Impedance of leg (right) 2.55 13 5 15.2 0.13 6.7e-01 ACTR1A ARL3 CADM2 COMMD7 CPSF4 MAP2K5 NAT6 NCAM1 NOB1 PRPS1P2 SRR TMEM161B-AS1 TMOD2
Leg fat-free mass (left) 2.21 9 5 15.2 -0.34 3.6e-01 ACTR1A CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 RP11-332O19.5 STX1B TMEM161B-AS1
Trunk fat percentage 2.08 8 2 6.1 -0.42 3.0e-01 C6orf3 CPSF4 GTF3C6 MAP2K5 NOB1 NPC1 STX1B TMEM161B-AS1
Hand grip strength (right) 2.53 4 3 9.1 -0.47 5.3e-01 ACTR1A NOB1 PRPS1P2 RP11-332O19.5
Townsend deprivation index at recruitment 2.73 3 0 0.0 0.00 1.0e+00 ACTR1A MAP2K5 PRPS1P2
Current tobacco smoking 5.27 7 3 9.1 -0.97 2.6e-04 ACTR1A ARL3 GTF3C6 NCAM1 PRPS1P2 RP11-332O19.5 RP11-89K21.1
Maternal smoking around birth 4.95 4 1 3.0 -0.97 2.9e-02 ACTR1A GTF3C6 RP11-332O19.5 RP5-1112D6.4
Fed-up feelings 1.22 1 0 0.0 0.00 1.0e+00 ATXN2
Taking other prescription medications 2.29 1 1 3.0 0.00 1.0e+00 ATXN2
Age when periods started (menarche) 2.68 5 2 6.1 0.30 6.3e-01 MAP2K5 MSH6 NAT6 NOB1 PRPS1P2
Heel bone mineral density (BMD) T-score, automated (left) 1.13 1 0 0.0 0.00 1.0e+00 REST
Qualifications: CSEs or equivalent 1.84 1 0 0.0 0.00 1.0e+00 COMMD7
High blood pressure 2.65 5 3 9.1 -0.72 1.7e-01 ARL3 ATXN2 MAP2K5 SRR TMEM161B-AS1
Hayfever, allergic rhinitis or eczema 2.12 3 0 0.0 0.00 1.0e+00 ARL3 RP11-332O19.5 SRR
Medication: Atenolol 1.89 1 1 3.0 0.00 1.0e+00 ATXN2
Medication: Levothyroxine sodium 3.02 1 1 3.0 0.00 1.0e+00 ATXN2
Sitting height 0.69 4 0 0.0 0.76 2.4e-01 CPSF4 NCAM1 PRPS1P2 RP11-332O19.5
Chronic bronchitis/emphysema (father) 1.83 1 0 0.0 0.00 1.0e+00 MAP2K5
Body mass index (BMI) 3.54 12 6 18.2 -0.59 4.4e-02 ACTR1A C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NOB1 NPC1 SRR STX1B TMEM161B-AS1
Impedance of leg (left) 2.67 13 4 12.1 0.11 7.2e-01 ACTR1A ARL3 CADM2 COMMD7 CPSF4 MAP2K5 NAT6 NOB1 PRPS1P2 SDK1 SRR TMEM161B-AS1 TMOD2
Leg predicted mass (left) 2.24 9 5 15.2 -0.34 3.8e-01 ACTR1A CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 RP11-332O19.5 STX1B TMEM161B-AS1
Trunk fat mass 2.33 9 2 6.1 -0.44 2.4e-01 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NOB1 NPC1 STX1B TMEM161B-AS1
Waist circumference 3.01 10 4 12.1 -0.53 1.1e-01 C6orf3 CADM2 CPSF4 MAP2K5 NAT6 NOB1 NPC1 RP11-332O19.5 STX1B TMEM161B-AS1
Alcohol usually taken with meals 2.19 1 0 0.0 0.00 1.0e+00 ACTR1A
Nervous feelings 3.78 4 2 6.1 0.82 1.8e-01 ACTR1A CADM2 PRPS1P2 SRR
Frequency of tenseness / restlessness in last 2 weeks 1.51 1 0 0.0 0.00 1.0e+00 RP5-1112D6.4
Hearing difficulty/problems with background noise 2.11 1 0 0.0 0.00 1.0e+00 NPC1
Forced vital capacity (FVC) 1.91 6 2 6.1 -0.38 4.5e-01 MSH6 NOB1 PRPS1P2 REST RP11-332O19.5 RPS26
Heel bone mineral density (BMD) T-score, automated (right) 1.23 2 0 0.0 0.00 1.0e+00 NCAM1 REST
Qualifications: None of the above 1.66 2 0 0.0 0.00 1.0e+00 ACTR1A NAT6
Mouth/teeth dental problems 1.36 1 0 0.0 0.00 1.0e+00 PRPS1P2
Heart attack 2.31 2 0 0.0 0.00 1.0e+00 ATXN2 NOB1
Allergy 1.53 3 0 0.0 0.00 1.0e+00 RP11-332O19.5 RPS26 SRR
Medication: Ramipril 1.39 1 0 0.0 0.00 1.0e+00 ATXN2
Illnesses of siblings 1.65 1 0 0.0 0.00 1.0e+00 ATXN2
Neuroticism score 1.79 2 0 0.0 0.00 1.0e+00 CADM2 PRPS1P2
Weight 2.64 10 6 18.2 -0.53 1.1e-01 ACTR1A C6orf3 CADM2 CPSF4 MAP2K5 NAT6 NPC1 RP11-332O19.5 STX1B TMEM161B-AS1
Impedance of arm (right) 2.41 7 3 9.1 0.96 4.6e-04 ACTR1A CADM2 CPSF4 MAP2K5 NAT6 REST STX1B
Arm fat percentage (right) 2.81 11 3 9.1 -0.44 1.7e-01 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NOB1 NPC1 SRR STX1B TMEM161B-AS1
Trunk fat-free mass 1.90 10 5 15.2 -0.47 1.7e-01 ACTR1A ATXN2 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST RP11-332O19.5 RPS26
Hip circumference 2.52 11 4 12.1 -0.41 2.1e-01 ACTR1A ATXN2 C6orf3 CADM2 CPSF4 MAP2K5 NAT6 NPC1 RP11-332O19.5 STX1B TMEM161B-AS1
Alcohol intake versus 10 years previously 1.99 1 0 0.0 0.00 1.0e+00 RP11-332O19.5
Father's age at death 2.13 2 0 0.0 0.00 1.0e+00 ATXN2 CCDC167
Worrier / anxious feelings 4.17 6 3 9.1 0.98 5.2e-04 ACTR1A CADM2 GTF3C6 RP11-332O19.5 STX1B TMEM180
Frequency of tiredness / lethargy in last 2 weeks 1.71 2 0 0.0 0.00 1.0e+00 PRPS1P2 TMOD2
Number of live births 1.59 1 0 0.0 0.00 1.0e+00 NAT6
Forced expiratory volume in 1-second (FEV1) 2.20 6 2 6.1 -0.03 9.5e-01 NOB1 PRPS1P2 REST RP11-332O19.5 RP11-89K21.1 RPS26
Pulse rate 1.94 1 0 0.0 0.00 1.0e+00 NAT6
Qualifications: A levels/AS levels or equivalent 1.63 2 0 0.0 0.00 1.0e+00 ACTR1A NAT6
Mouth/teeth dental problems: Dentures 1.81 1 0 0.0 0.00 1.0e+00 NAT6
Forced expiratory volume in 1-second (FEV1), Best measure 1.96 5 2 6.1 -0.33 5.8e-01 NOB1 PRPS1P2 REST RP11-332O19.5 RPS26
Impedance of arm (left) 2.51 7 3 9.1 0.97 2.9e-04 ACTR1A CADM2 CPSF4 MAP2K5 NAT6 REST STX1B
Arm fat mass (right) 3.03 12 5 15.2 -0.52 8.3e-02 ACTR1A C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NOB1 NPC1 SRR STX1B TMEM161B-AS1
Trunk predicted mass 1.90 11 5 15.2 -0.49 1.3e-01 ACTR1A ATXN2 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST RP11-332O19.5 RPS26 STX1B
Standing height 0.76 7 1 3.0 0.03 9.5e-01 ATXN2 CPSF4 NAT6 NCAM1 PRPS1P2 REST RP11-332O19.5
Exposure to tobacco smoke at home 2.48 2 0 0.0 0.00 1.0e+00 C6orf3 RP11-89K21.1
Tense / 'highly strung' 1.64 1 1 3.0 0.00 1.0e+00 CADM2
Hair/balding pattern: Pattern 4 1.69 2 1 3.0 0.00 1.0e+00 C6orf3 SRR
Birth weight of first child 1.54 1 1 3.0 0.00 1.0e+00 ATXN2
Peak expiratory flow (PEF) 2.01 4 2 6.1 -0.62 3.8e-01 ACTR1A PRPS1P2 REST RP11-332O19.5
Pulse wave reflection index 2.53 1 0 0.0 0.00 1.0e+00 NAT6
Blood clot in the leg (DVT) 1.51 1 0 0.0 0.00 1.0e+00 ATXN2
Medication: Paracetamol 1.59 1 0 0.0 0.00 1.0e+00 COMMD7
Headache pain in last month 1.94 1 0 0.0 0.00 1.0e+00 MAP2K5
Medication for cholesterol, blood pressure or diabetes 2.05 2 0 0.0 0.00 1.0e+00 ATXN2 MAP2K5
Gout (self-reported) 1.59 1 0 0.0 0.00 1.0e+00 ATXN2
Hypothyroidism/myxoedema (self-reported) 2.63 1 1 3.0 0.00 1.0e+00 ATXN2
Birth weight 1.90 2 1 3.0 0.00 1.0e+00 ATXN2 SRR
Forced vital capacity (FVC), Best measure 1.75 6 1 3.0 -0.34 5.0e-01 MSH6 NOB1 PRPS1P2 REST RP11-332O19.5 RPS26
Body fat percentage 2.41 7 2 6.1 -0.39 3.9e-01 C6orf3 CPSF4 GTF3C6 MAP2K5 NPC1 STX1B TMEM161B-AS1
Leg fat percentage (right) 2.59 9 2 6.1 -0.69 3.8e-02 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NPC1 RP5-1112D6.4 STX1B
Arm fat-free mass (right) 2.35 10 5 15.2 -0.46 1.8e-01 ACTR1A ATXN2 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST RP11-332O19.5 STX1B
Exposure to tobacco smoke outside home 2.75 3 0 0.0 0.00 1.0e+00 ACTR1A NAT6 RP11-332O19.5
Comparative body size at age 10 3.89 6 4 12.1 0.12 8.1e-01 CADM2 MAP2K5 NAT6 NPC1 SRR TMEM161B-AS1
Worry too long after embarrassment 2.16 1 0 0.0 0.00 1.0e+00 MAP2K5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.57 1 0 0.0 0.00 1.0e+00 PRPS1P2
Number of children fathered 1.83 1 0 0.0 0.00 1.0e+00 CADM2
Age at first live birth 2.05 1 0 0.0 0.00 1.0e+00 NAT6
Shortness of breath walking on level ground 1.55 1 0 0.0 0.00 1.0e+00 COMMD7
Qualifications: College or University degree 1.99 4 2 6.1 0.96 4.1e-02 ACTR1A NAT6 PRPS1P2 SDK1
Medication for pain relief, constipation, heartburn 1.88 1 0 0.0 0.00 1.0e+00 COMMD7
Medication: Blood pressure 2.24 1 1 3.0 0.00 1.0e+00 ATXN2
Angina (self-reported) 1.37 1 0 0.0 0.00 1.0e+00 NOB1
Migraine (self-reported) 1.59 1 0 0.0 0.00 1.0e+00 ARL3
Medication: Allopurinol 1.63 1 0 0.0 0.00 1.0e+00 ATXN2
Mean time to correctly identify matches 2.53 2 1 3.0 0.00 1.0e+00 ATXN2 COMMD7
Heart disease (mother) 1.40 1 0 0.0 0.00 1.0e+00 NCAM1
Whole body fat mass 2.78 10 3 9.1 -0.53 1.2e-01 ACTR1A C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NPC1 STX1B TMEM161B-AS1
Leg fat mass (right) 3.26 10 5 15.2 -0.72 1.8e-02 ACTR1A C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NPC1 RP11-332O19.5 STX1B
Arm predicted mass (right) 2.29 10 5 15.2 -0.46 1.9e-01 ACTR1A ATXN2 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST RP11-332O19.5 STX1B
Pulse rate, automated reading 1.91 4 1 3.0 0.57 4.3e-01 CPSF4 MSH6 NAT6 TMEM161B-AS1
Alcohol intake frequency. 2.88 4 3 9.1 1.00 4.7e-03 CADM2 NPC1 REST RP11-89K21.1
Comparative height size at age 10 0.84 3 1 3.0 0.00 1.0e+00 ATXN2 NAT6 RP11-332O19.5
Number of full sisters 1.76 1 0 0.0 0.00 1.0e+00 CADM2
Suffer from 'nerves' 2.85 1 1 3.0 0.00 1.0e+00 CADM2
Overall health rating 1.65 1 0 0.0 0.00 1.0e+00 PRPS1P2
Age at last live birth 2.01 2 0 0.0 0.00 1.0e+00 CADM2 NAT6
Qualifications: NVQ or HND or HNC or equivalent 2.47 2 0 0.0 0.00 1.0e+00 ATXN2 SDK1
Medication: Aspirin 1.58 1 0 0.0 0.00 1.0e+00 ATXN2
Knee pain experienced in last month 1.83 1 0 0.0 0.00 1.0e+00 ACTR1A
Hypertension (Self-reported) 2.41 4 1 3.0 -0.58 4.2e-01 ARL3 ATXN2 MAP2K5 SRR
Illnesses of father: Heart disease 1.18 1 0 0.0 0.00 1.0e+00 ATXN2
Smoking status: Previous 14.64 27 6 18.2 -0.99 2.6e-23 ACTR1A ARL3 ATXN2 C6orf3 CADM2 CCDC167 COMMD7 CPSF4 GTF3C6 MAP2K5 MSH6 NAT6 NCAM1 NOB1 NPC1 REST RP11-332O19.5 RP11-89K21.1 RP5-1112D6.4 RPS26 SDK1 SRR STX1B TMEM161B-AS1 TMEM180 TMEM242 TMOD2
Forced expiratory volume in 1-second (FEV1), predicted 1.12 1 0 0.0 0.00 1.0e+00 SDK1
Whole body fat-free mass 2.03 11 4 12.1 -0.49 1.3e-01 ACTR1A ATXN2 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST RP11-332O19.5 RPS26 STX1B
Leg fat-free mass (right) 2.04 9 3 9.1 -0.33 3.9e-01 ACTR1A CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 RP11-332O19.5 STX1B TMEM161B-AS1
Arm fat percentage (left) 2.76 11 3 9.1 -0.43 1.9e-01 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NOB1 NPC1 SRR STX1B TMEM161B-AS1
Average weekly red wine intake 3.23 2 1 3.0 0.00 1.0e+00 CADM2 NPC1
Mood swings 1.20 1 0 0.0 0.00 1.0e+00 ATXN2
Long-standing illness, disability or infirmity 2.53 2 0 0.0 0.00 1.0e+00 GTF3C6 RP5-1112D6.4
Qualifications: nursing, teaching 1.40 1 0 0.0 0.00 1.0e+00 SDK1
Mouth/teeth dental problems: Mouth ulcers 1.48 1 0 0.0 0.00 1.0e+00 CADM2
Medication for cholesterol 1.42 1 0 0.0 0.00 1.0e+00 ATXN2
Mineral and other dietary supplements 1.77 1 0 0.0 0.00 1.0e+00 ACTR1A
Medication: Aspirin 1.54 1 0 0.0 0.00 1.0e+00 ATXN2
Illnesses of father: None of the above (group 1) 1.66 1 0 0.0 0.00 1.0e+00 ATXN2
Smoking status: Current 5.46 6 3 9.1 -0.97 1.2e-03 ACTR1A GTF3C6 NCAM1 PRPS1P2 RP11-332O19.5 RP11-89K21.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.28 4 0 0.0 0.56 4.4e-01 PRPS1P2 REST STX1B TMEM180
Whole body water mass 2.05 11 4 12.1 -0.48 1.3e-01 ACTR1A ATXN2 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST RP11-332O19.5 RPS26 STX1B
Leg predicted mass (right) 2.05 9 3 9.1 -0.33 3.9e-01 ACTR1A CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 RP11-332O19.5 STX1B TMEM161B-AS1
Arm fat mass (left) 3.06 11 5 15.2 -0.60 5.1e-02 ACTR1A C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NOB1 NPC1 STX1B TMEM161B-AS1
Number of self-reported non-cancer illnesses 2.12 2 1 3.0 0.00 1.0e+00 ATXN2 MAP2K5
Miserableness 1.09 1 0 0.0 0.00 1.0e+00 NCAM1
Eye problems/disorders: Glaucoma 1.12 1 0 0.0 0.00 1.0e+00 MAP2K5
Medication: Blood pressure 1.67 2 1 3.0 0.00 1.0e+00 ARL3 ATXN2
Supplements: Fish oil (including cod liver oil) 1.67 1 0 0.0 0.00 1.0e+00 CPSF4
Medication: Bendroflumethiazide 1.47 2 0 0.0 0.00 1.0e+00 ARL3 ATXN2
Medication: Paracetamol 1.19 1 0 0.0 0.00 1.0e+00 COMMD7
Ever smoked 15.28 28 13 39.4 -0.99 1.6e-26 ACTR1A ARL3 ATXN2 C6orf3 CADM2 CCDC167 COMMD7 CPSF4 GTF3C6 MAP2K5 MSH6 NAT6 NCAM1 NOB1 NPC1 PRPS1P2 REST RP11-332O19.5 RP11-89K21.1 RP5-1112D6.4 RPS26 SDK1 SRR STX1B TMEM161B-AS1 TMEM180 TMEM242 TMOD2
Basal metabolic rate 2.17 10 6 18.2 -0.43 2.2e-01 ACTR1A ATXN2 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST RP11-332O19.5 STX1B
Leg fat percentage (left) 2.62 9 2 6.1 -0.69 3.8e-02 C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NPC1 RP5-1112D6.4 STX1B
Arm fat-free mass (left) 2.36 10 4 12.1 -0.44 2.0e-01 ACTR1A ATXN2 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST RP11-332O19.5 STX1B
Number of operations (self-reported) 1.18 1 0 0.0 0.00 1.0e+00 NAT6
Average weekly beer plus cider intake 2.89 3 0 0.0 0.00 1.0e+00 NAT6 RP11-89K21.1 TMOD2
Risk taking 3.70 3 1 3.0 0.00 1.0e+00 CADM2 RP11-89K21.1 TMEM242
Diastolic blood pressure, automated reading 3.09 4 2 6.1 0.20 8.0e-01 ATXN2 MAP2K5 NPC1 SRR
Vascular/heart problems diagnosed by doctor 2.80 5 3 9.1 0.75 1.5e-01 ARL3 ATXN2 MAP2K5 SRR TMEM161B-AS1
Pain experienced in last month 2.64 3 0 0.0 0.00 1.0e+00 ATXN2 COMMD7 PRPS1P2
Heart attack/myocardial infarction (self-reported) 2.22 2 0 0.0 0.00 1.0e+00 ATXN2 NOB1
Impedance of whole body 2.74 7 4 12.1 0.82 2.5e-02 ACTR1A CADM2 CPSF4 MAP2K5 NAT6 PRPS1P2 STX1B
Leg fat mass (left) 3.22 10 5 15.2 -0.72 1.9e-02 ACTR1A C6orf3 CADM2 CPSF4 GTF3C6 MAP2K5 NAT6 NPC1 RP11-332O19.5 STX1B
Arm predicted mass (left) 2.40 10 5 15.2 -0.45 2.0e-01 ACTR1A ATXN2 CADM2 MAP2K5 NAT6 NPC1 PRPS1P2 REST RP11-332O19.5 STX1B

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 4 0.1146 1.93
GTEx Adipose Visceral Omentum 3 0.1473 1.97
GTEx Adrenal Gland 1 0.0686 1.83
GTEx Artery Aorta 3 0.1008 1.88
GTEx Artery Coronary 2 0.1691 2.02
GTEx Artery Tibial 5 0.1329 1.91
GTEx Brain Caudate basal ganglia 0 0.0000 1.90
GTEx Brain Cerebellar Hemisphere 4 0.2686 2.09
GTEx Brain Cerebellum 7 0.3532 2.11
GTEx Brain Cortex 1 0.0966 2.07
GTEx Brain Frontal Cortex BA9 0 0.0000 1.97
GTEx Brain Hippocampus 1 0.1908 2.10
GTEx Brain Hypothalamus 2 0.3390 2.12
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.87
GTEx Brain Putamen basal ganglia 0 0.0000 1.70
GTEx Breast Mammary Tissue 1 0.0507 2.00
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.85
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.89
GTEx Cells EBV-transformed lymphocytes 2 0.1405 2.00
GTEx Cells Transformed fibroblasts 1 0.0238 1.87
GTEx Colon Sigmoid 0 0.0000 1.93
GTEx Colon Transverse 1 0.0484 1.97
GTEx Esophagus Gastroesophageal Junction 1 0.0692 1.94
GTEx Esophagus Mucosa 1 0.0301 1.83
GTEx Esophagus Muscularis 3 0.0928 1.95
GTEx Heart Atrial Appendage 1 0.0633 1.86
GTEx Heart Left Ventricle 1 0.0654 1.91
GTEx Liver 2 0.2789 2.03
GTEx Lung 1 0.0348 1.99
GTEx Muscle Skeletal 3 0.1038 1.92
GTEx Nerve Tibial 3 0.0694 1.87
GTEx Ovary 0 0.0000 2.05
GTEx Pancreas 1 0.0613 2.01
GTEx Pituitary 1 0.0897 1.99
GTEx Prostate 1 0.1198 1.97
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.98
GTEx Skin Sun Exposed Lower leg 5 0.1374 1.94
GTEx Small Intestine Terminal Ileum 0 0.0000 2.03
GTEx Spleen 1 0.0709 1.95
GTEx Stomach 1 0.0688 1.93
GTEx Testis 3 0.0951 1.90
GTEx Thyroid 4 0.1000 1.94
GTEx Uterus 1 0.1764 2.00
GTEx Vagina 0 0.0000 1.82
GTEx Whole Blood 0 0.0000 1.98
METSIM Adipose 9 0.1952 1.80
NTR Blood 5 0.2082 1.73
ROSMAP Brain Pre-frontal Cortex 6 0.1366 1.84
YFS Blood 1 0.0217 1.75
CommonMind Brain Pre-frontal Cortex 11 0.2047 1.84
TCGA Breast Tumor 3 0.3911 2.11
TCGA Breast Normal 4 0.0951 1.68
TCGA Ovarian Tumor 1 0.0342 1.65
TCGA Prostate Tumor 5 0.1446 1.75