Hub : Traits :

Birth weight of first child

148 significantly associated models · 60 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 2036263 2 1 1.3e-07 3.3e-06 5.6e-01 98 SCNN1D
2 1 11170131 12600396 3 2 1.0e-09 2.4e-11 8.6e-02 93 CLCN6
3 2 8934921 10394558 1 1 1.7e-08 1.5e-07 3.7e-01 97 ADAM17
4 2 10886098 12295638 1 1 4.8e-08 7.0e-08 1.0e+00 100 E2F6
5 3 122306920 123860565 2 1 1.4e-12 1.8e-11 2.8e-01 97 ADCY5
6 3 140350567 141867638 1 1 6.0e-08 1.1e-07 1.0e+00 100 ZBTB38
7 3 155070465 156966235 3 1 2.7e-22 3.5e-22 1.0e+00 100 KCNAB1
8 4 17104059 18507692 1 1 8.2e-08 4.2e-08 3.6e-02 85 DCAF16
9 4 105598022 107092169 1 1 1.6e-12 2.8e-16 4.1e-08 55 PPA2
10 4 144758204 146706624 2 1 1.1e-09 2.5e-10 1.4e-02 85 ANAPC10
11 6 34399814 36158878 4 2 4.3e-13 1.1e-12 3.9e-03 84 TEAD3 ZNF76
12 7 98341025 100221867 4 3 1.1e-08 1.1e-08 1.0e+00 100 GJC3 GS1-259H13.2 ZKSCAN5
13 8 22687572 24125172 1 1 1.0e-07 4.5e-07 6.7e-02 87 SLC25A37
14 8 77201682 78607709 1 1 2.3e-08 1.4e-08 9.3e-03 79 PEX2
15 8 140969818 142706843 1 1 3.8e-09 8.9e-06 5.5e-01 98 PTK2
16 10 95379543 96988739 2 4 2.2e-15 3.9e-14 1.0e+00 100 NOC3L TBC1D12
17 10 103905779 105647095 2 1 5.7e-08 9.1e-08 1.0e+00 100 NT5C2
18 11 101228512 102802722 3 1 3.0e-11 8.7e-12 1.0e+00 100 RP11-864G5.3
19 12 30084002 31526510 1 1 4.7e-10 2.4e-08 6.0e-01 99 IPO8
20 12 55694116 57082058 1 1 1.6e-07 5.4e-07 2.4e-02 80 SUOX
21 12 111154626 113517494 8 1 7.1e-13 1.3e-20 8.9e-10 57 SH2B3
22 15 74488424 76108550 2 1 8.0e-08 8.7e-07 6.7e-01 99 MPI
23 15 85227407 86990983 2 1 3.3e-09 1.3e-12 7.7e-05 69 RP11-158M2.3
24 15 90712555 92135418 2 1 3.5e-13 7.7e-13 1.3e-01 96 FES
25 17 6444676 7836958 1 1 4.0e-07 3.4e-06 3.5e-02 80 GABARAP
26 17 16718225 18194248 1 1 2.2e-07 2.6e-11 8.3e-06 55 PEMT
27 17 79284007 80694826 3 1 2.7e-08 6.9e-08 4.6e-02 86 DCXR
28 20 46551079 48140682 1 1 3.3e-07 7.7e-08 2.3e-02 82 PREX1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.45 1 0 0.0 0.00 1.0e+00 GJC3
Crohns Disease (2017) 1.46 1 1 3.0 0.00 1.0e+00 ZBTB38
Irritable Bowel Disease (IBD) 1.81 2 0 0.0 0.00 1.0e+00 IPO8 TEAD3
Ulcerative Colitis (UC) 2.06 3 0 0.0 0.00 1.0e+00 IPO8 PPA2 TEAD3
Major Depression (MDD) 1.73 1 0 0.0 0.00 1.0e+00 FES
Reaction Time 1.99 1 1 3.0 0.00 1.0e+00 SH2B3
Verbal and Numeric Reasoning (VNR) 1.99 4 1 3.0 -1.00 2.9e-03 DCAF16 PPA2 PREX1 SUOX
Breast Cancer 1.85 3 1 3.0 0.00 1.0e+00 FES MPI ZBTB38
Prostate Cancer 1.94 1 0 0.0 0.00 1.0e+00 ZBTB38
Coronary Artery Disease (CAD) 3.07 3 0 0.0 0.00 1.0e+00 DCAF16 NT5C2 SH2B3
Crohns Disease (2012) 1.14 1 0 0.0 0.00 1.0e+00 ZBTB38
HbA1C 1.31 1 0 0.0 0.00 1.0e+00 ZKSCAN5
LDL Cholesterol 1.89 2 0 0.0 0.00 1.0e+00 MPI SH2B3
Lupus 2.05 2 0 0.0 0.00 1.0e+00 MPI ZNF76
Primary Biliary Cirrhosis 1.63 1 1 3.0 0.00 1.0e+00 SH2B3
Rheumatoid Arthritis 1.56 2 0 0.0 0.00 1.0e+00 SH2B3 SUOX
Schizophrenia 1.78 2 2 6.1 0.00 1.0e+00 FES NT5C2
Blood Eosinophil Count 6.49 7 5 15.2 0.47 2.9e-01 ADCY5 CLCN6 RP11-158M2.3 SH2B3 SUOX TEAD3 ZNF76
Blood Platelet Count 1.63 11 5 15.2 0.20 5.6e-01 ADCY5 CLCN6 DCAF16 MPI NT5C2 RP11-158M2.3 RP11-864G5.3 SH2B3 SLC25A37 TBC1D12 ZKSCAN5
Blood Red Count 2.76 12 7 21.2 0.23 4.4e-01 CLCN6 GJC3 MPI PREX1 PTK2 RP11-158M2.3 SH2B3 SUOX TBC1D12 TEAD3 ZBTB38 ZKSCAN5
Blood White Count 3.98 10 6 18.2 0.65 4.3e-02 DCAF16 FES GS1-259H13.2 NT5C2 PPA2 PTK2 RP11-864G5.3 SH2B3 TBC1D12 ZNF76
Heel T-Score 1.44 8 4 12.1 0.33 4.2e-01 ANAPC10 DCAF16 DCXR GS1-259H13.2 IPO8 SUOX ZBTB38 ZNF76
BMI 1.59 7 6 18.2 -0.03 9.4e-01 CLCN6 DCAF16 GS1-259H13.2 MPI NT5C2 SLC25A37 SUOX
Height 7.97 22 18 54.5 -0.60 2.1e-03 ADAM17 ADCY5 ANAPC10 DCAF16 DCXR FES GJC3 GS1-259H13.2 IPO8 KCNAB1 NOC3L NT5C2 PEMT PPA2 PREX1 RP11-864G5.3 SH2B3 TBC1D12 TEAD3 ZBTB38 ZKSCAN5 ZNF76
Waist Hip Ratio (WHR) 1.94 10 2 6.1 0.50 1.5e-01 ADAM17 ANAPC10 DCXR GABARAP IPO8 MPI NOC3L PEMT PTK2 ZBTB38
Systolic Blood Pressure 9.02 14 11 33.3 0.82 1.7e-04 CLCN6 DCAF16 FES GABARAP MPI NT5C2 PEX2 PREX1 RP11-158M2.3 SCNN1D SH2B3 SLC25A37 SUOX TBC1D12
Smoking Status 2.60 5 2 6.1 -0.33 5.9e-01 FES GS1-259H13.2 NT5C2 PTK2 SUOX
Allergy or Eczema 3.49 7 3 9.1 -0.48 2.7e-01 CLCN6 FES MPI SH2B3 SUOX ZBTB38 ZKSCAN5
Cardiovascular Disease 5.96 9 6 18.2 0.85 2.0e-03 CLCN6 DCAF16 FES MPI NOC3L SH2B3 SUOX TBC1D12 ZNF76
Hypothyroidism (self reported) 5.50 5 3 9.1 0.37 5.4e-01 PTK2 SCNN1D SH2B3 SLC25A37 SUOX
Respiratory disease 2.49 3 2 6.1 0.00 1.0e+00 FES SUOX ZNF76
Type 2 Diabetes (T2D) 1.52 2 0 0.0 0.00 1.0e+00 GS1-259H13.2 SH2B3
Lung FEV1/FVC ratio 2.64 7 4 12.1 -0.40 3.3e-01 ADAM17 GJC3 NOC3L PPA2 SUOX ZBTB38 ZNF76
Lung FVC 2.30 11 7 21.2 -0.38 2.5e-01 ANAPC10 DCAF16 DCXR GABARAP IPO8 PPA2 SH2B3 SUOX TEAD3 ZBTB38 ZNF76
Neuroticism 1.12 1 0 0.0 0.00 1.0e+00 NT5C2
Hair Pigment 0.78 7 4 12.1 -0.72 7.0e-02 DCXR FES PEMT SH2B3 SUOX ZBTB38 ZNF76
Tanning 0.29 4 0 0.0 -0.44 5.6e-01 MPI NT5C2 SH2B3 TEAD3
Hand grip strength (left) 2.57 6 2 6.1 0.97 1.3e-03 DCAF16 FES GS1-259H13.2 NT5C2 ZBTB38 ZNF76
Number of treatments/medications taken 2.25 3 1 3.0 0.00 1.0e+00 FES GABARAP SH2B3
Sensitivity / hurt feelings 1.26 1 0 0.0 0.00 1.0e+00 FES
Hearing difficulty/problems: Yes 1.38 1 1 3.0 0.00 1.0e+00 PTK2
Relative age of first facial hair 1.00 1 0 0.0 0.00 1.0e+00 ZBTB38
Other serious medical condition/disability diagnosed by doctor 1.69 1 0 0.0 0.00 1.0e+00 PPA2
Systolic blood pressure, automated reading 6.66 12 7 21.2 -0.87 1.2e-04 CLCN6 DCAF16 FES GABARAP MPI NT5C2 PEX2 PPA2 PREX1 SCNN1D SH2B3 TBC1D12
Angina 2.25 1 1 3.0 0.00 1.0e+00 FES
Impedance of leg (right) 1.48 7 3 9.1 -0.42 3.5e-01 FES IPO8 NT5C2 PPA2 PTK2 SUOX TBC1D12
Leg fat-free mass (left) 4.63 14 5 15.2 0.71 4.8e-03 ANAPC10 DCAF16 FES IPO8 NT5C2 PPA2 PTK2 SH2B3 SLC25A37 SUOX TBC1D12 TEAD3 ZBTB38 ZNF76
Trunk fat percentage 1.89 9 2 6.1 -0.39 3.0e-01 ADCY5 CLCN6 GS1-259H13.2 MPI SLC25A37 TBC1D12 TEAD3 ZBTB38 ZNF76
Hand grip strength (right) 2.01 4 2 6.1 0.99 1.2e-02 DCAF16 NT5C2 ZBTB38 ZNF76
Current tobacco smoking 1.86 1 1 3.0 0.00 1.0e+00 NT5C2
Maternal smoking around birth 1.54 2 0 0.0 0.00 1.0e+00 GS1-259H13.2 NT5C2
Fed-up feelings 1.53 2 1 3.0 0.00 1.0e+00 GABARAP SH2B3
Taking other prescription medications 1.87 1 1 3.0 0.00 1.0e+00 SH2B3
Age when periods started (menarche) 1.65 2 0 0.0 0.00 1.0e+00 PEX2 SUOX
High blood pressure 6.28 9 5 15.2 -0.94 3.8e-05 CLCN6 DCAF16 FES MPI PTK2 SH2B3 SUOX TBC1D12 TEAD3
Hayfever, allergic rhinitis or eczema 3.01 5 2 6.1 0.59 2.9e-01 FES MPI SUOX ZBTB38 ZKSCAN5
Stomach or abdominal pain in last month 1.22 1 0 0.0 0.00 1.0e+00 PPA2
Medication: Atenolol 3.84 4 2 6.1 -0.73 2.7e-01 FES GABARAP SH2B3 TBC1D12
Medication: Levothyroxine sodium 4.56 3 2 6.1 0.00 1.0e+00 SCNN1D SH2B3 SUOX
Sitting height 7.09 14 11 33.3 0.72 1.5e-03 ADCY5 ANAPC10 DCAF16 DCXR GJC3 GS1-259H13.2 NOC3L NT5C2 PPA2 PREX1 TBC1D12 TEAD3 ZBTB38 ZNF76
Chronic bronchitis/emphysema (father) 1.65 1 0 0.0 0.00 1.0e+00 PTK2
High blood pressure (mother) 3.78 3 1 3.0 -0.96 4.1e-02 CLCN6 FES MPI
Body mass index (BMI) 1.48 8 1 3.0 -0.08 8.4e-01 CLCN6 DCAF16 GS1-259H13.2 MPI NT5C2 PREX1 SLC25A37 SUOX
Impedance of leg (left) 1.52 6 3 9.1 -0.33 5.2e-01 FES NT5C2 PPA2 PTK2 SUOX TBC1D12
Leg predicted mass (left) 4.63 14 5 15.2 0.71 4.7e-03 ANAPC10 DCAF16 FES IPO8 NT5C2 PPA2 PTK2 SH2B3 SLC25A37 SUOX TBC1D12 TEAD3 ZBTB38 ZNF76
Trunk fat mass 2.35 8 3 9.1 0.33 4.2e-01 ADCY5 ANAPC10 CLCN6 GS1-259H13.2 MPI NT5C2 SLC25A37 ZBTB38
Waist circumference 1.92 8 3 9.1 0.18 6.8e-01 ADCY5 CLCN6 GS1-259H13.2 MPI NT5C2 SLC25A37 SUOX ZBTB38
Number of incorrect matches in round 1.44 2 0 0.0 0.00 1.0e+00 NT5C2 PREX1
Past tobacco smoking 2.50 4 1 3.0 0.44 5.6e-01 GS1-259H13.2 NT5C2 SH2B3 SUOX
Alcohol usually taken with meals 1.20 1 0 0.0 0.00 1.0e+00 FES
Nervous feelings 1.22 1 1 3.0 0.00 1.0e+00 NT5C2
Hearing difficulty/problems with background noise 1.68 1 0 0.0 0.00 1.0e+00 MPI
Had other major operations 1.81 1 0 0.0 0.00 1.0e+00 PPA2
Forced vital capacity (FVC) 5.85 9 9 27.3 0.98 1.5e-06 ANAPC10 DCAF16 DCXR IPO8 PPA2 PREX1 TEAD3 ZBTB38 ZNF76
Heel bone mineral density (BMD) T-score, automated (right) 1.03 1 0 0.0 0.00 1.0e+00 ZBTB38
Qualifications: None of the above 1.90 3 0 0.0 0.00 1.0e+00 PPA2 PTK2 SUOX
Financial difficulties in last 2 years 1.32 1 0 0.0 0.00 1.0e+00 MPI
Mouth/teeth dental problems 1.35 1 0 0.0 0.00 1.0e+00 PTK2
Heart attack 2.33 2 1 3.0 0.00 1.0e+00 FES SH2B3
Allergy 2.98 5 2 6.1 -0.37 5.3e-01 FES SUOX ZBTB38 ZKSCAN5 ZNF76
Diabetes (self-reported) 1.12 1 0 0.0 0.00 1.0e+00 GS1-259H13.2
Hayfever/allergic rhinitis (self-reported) 2.89 2 1 3.0 0.00 1.0e+00 SUOX ZKSCAN5
Medication: Ramipril 1.99 2 0 0.0 0.00 1.0e+00 FES MPI
Medication: Simvastatin 1.96 2 1 3.0 0.00 1.0e+00 DCAF16 FES
Fluid intelligence score 2.18 3 1 3.0 0.00 1.0e+00 DCAF16 PPA2 SUOX
Illnesses of siblings 2.55 3 0 0.0 0.00 1.0e+00 CLCN6 FES SH2B3
Weight 3.57 11 5 15.2 0.61 4.6e-02 ADCY5 ANAPC10 CLCN6 DCAF16 MPI NT5C2 PPA2 SH2B3 SLC25A37 SUOX ZBTB38
Impedance of arm (right) 1.33 4 1 3.0 0.09 9.1e-01 RP11-864G5.3 SH2B3 SUOX TBC1D12
Arm fat percentage (right) 1.74 8 2 6.1 -0.48 2.3e-01 CLCN6 DCAF16 GS1-259H13.2 MPI PREX1 SLC25A37 TEAD3 ZNF76
Trunk fat-free mass 6.15 17 9 27.3 0.74 6.3e-04 ADAM17 ANAPC10 DCAF16 GJC3 IPO8 NOC3L NT5C2 PPA2 PREX1 PTK2 SH2B3 SLC25A37 SUOX TBC1D12 TEAD3 ZBTB38 ZNF76
Hip circumference 2.93 8 5 15.2 0.68 6.5e-02 ADCY5 ANAPC10 CLCN6 MPI NT5C2 SH2B3 SLC25A37 ZBTB38
Alcohol intake versus 10 years previously 1.45 1 0 0.0 0.00 1.0e+00 GS1-259H13.2
Father's age at death 3.29 2 2 6.1 0.00 1.0e+00 FES SH2B3
Worrier / anxious feelings 1.15 1 1 3.0 0.00 1.0e+00 NT5C2
Frequency of tiredness / lethargy in last 2 weeks 1.79 1 0 0.0 0.00 1.0e+00 MPI
Forced expiratory volume in 1-second (FEV1) 6.28 12 9 27.3 0.90 9.4e-06 ANAPC10 DCAF16 DCXR GJC3 IPO8 NOC3L PPA2 PREX1 SUOX TEAD3 ZBTB38 ZNF76
Pulse rate 1.98 2 1 3.0 0.00 1.0e+00 RP11-864G5.3 ZBTB38
Qualifications: A levels/AS levels or equivalent 1.53 3 0 0.0 0.00 1.0e+00 PPA2 PREX1 SUOX
Asthma 2.65 4 2 6.1 0.53 4.7e-01 CLCN6 SUOX ZBTB38 ZNF76
Medication: Cholesterol lowering 2.54 2 1 3.0 0.00 1.0e+00 CLCN6 FES
Medication: Lansoprazole 1.29 1 0 0.0 0.00 1.0e+00 SH2B3
Illnesses of mother 2.22 1 1 3.0 0.00 1.0e+00 FES
Forced expiratory volume in 1-second (FEV1), Best measure 6.49 12 10 30.3 0.90 1.1e-05 ANAPC10 DCAF16 DCXR GJC3 IPO8 NOC3L PPA2 PREX1 SUOX TEAD3 ZBTB38 ZNF76
Pulse wave Arterial Stiffness index 2.25 1 0 0.0 0.00 1.0e+00 NT5C2
Impedance of arm (left) 1.34 6 1 3.0 -0.19 7.2e-01 NT5C2 RP11-864G5.3 SH2B3 SUOX TBC1D12 TEAD3
Arm fat mass (right) 1.88 8 1 3.0 0.51 1.9e-01 ANAPC10 CLCN6 GS1-259H13.2 MPI NT5C2 SLC25A37 SUOX ZBTB38
Trunk predicted mass 6.16 15 8 24.2 0.76 1.1e-03 ADAM17 ANAPC10 DCAF16 GJC3 IPO8 NOC3L NT5C2 PPA2 PTK2 SH2B3 SUOX TBC1D12 TEAD3 ZBTB38 ZNF76
Standing height 7.63 16 13 39.4 0.72 7.4e-04 ADAM17 ADCY5 ANAPC10 DCAF16 DCXR GJC3 GS1-259H13.2 IPO8 NOC3L NT5C2 PPA2 PREX1 SH2B3 TEAD3 ZBTB38 ZNF76
Breastfed as a baby 1.60 1 1 3.0 0.00 1.0e+00 SCNN1D
Hair/balding pattern: Pattern 4 1.74 2 1 3.0 0.00 1.0e+00 PEX2 ZBTB38
Peak expiratory flow (PEF) 3.61 9 2 6.1 0.77 1.6e-02 ANAPC10 DCAF16 GJC3 MPI NT5C2 PPA2 PREX1 SCNN1D ZNF76
Mouth/teeth dental problems: Bleeding gums 1.66 1 0 0.0 0.00 1.0e+00 PPA2
Blood clot in the leg (DVT) 1.19 1 0 0.0 0.00 1.0e+00 SH2B3
Medication: Paracetamol 1.99 1 1 3.0 0.00 1.0e+00 PTK2
Headache pain in last month 1.48 1 0 0.0 0.00 1.0e+00 IPO8
Medication for cholesterol, blood pressure or diabetes 4.52 5 3 9.1 0.73 9.7e-02 CLCN6 FES GABARAP MPI SH2B3
Gout (self-reported) 1.53 1 0 0.0 0.00 1.0e+00 SH2B3
Hypothyroidism/myxoedema (self-reported) 4.74 4 2 6.1 -0.53 4.7e-01 PTK2 SCNN1D SH2B3 SUOX
Medication: Amlodipine 2.83 2 2 6.1 0.00 1.0e+00 CLCN6 FES
Medication: Ventolin 100micrograms inhaler 1.55 1 0 0.0 0.00 1.0e+00 SUOX
Birth weight 9.09 18 9 27.3 0.97 2.8e-11 ADAM17 ADCY5 ANAPC10 DCAF16 FES GABARAP NT5C2 PPA2 PREX1 PTK2 RP11-158M2.3 RP11-864G5.3 SH2B3 SLC25A37 SUOX TBC1D12 TEAD3 ZNF76
High blood pressure (siblings) 3.08 3 2 6.1 0.00 1.0e+00 CLCN6 FES SH2B3
Forced vital capacity (FVC), Best measure 5.81 10 8 24.2 0.97 2.0e-06 ANAPC10 DCAF16 DCXR IPO8 NOC3L PPA2 PREX1 TEAD3 ZBTB38 ZNF76
Body fat percentage 1.89 9 2 6.1 -0.41 2.7e-01 CLCN6 GS1-259H13.2 MPI PREX1 SLC25A37 TBC1D12 TEAD3 ZBTB38 ZNF76
Leg fat percentage (right) 2.01 9 3 9.1 -0.48 2.0e-01 CLCN6 DCAF16 GS1-259H13.2 MPI PREX1 SLC25A37 TBC1D12 TEAD3 ZNF76
Arm fat-free mass (right) 5.28 16 8 24.2 0.62 1.0e-02 ADAM17 ADCY5 ANAPC10 DCAF16 GJC3 IPO8 NT5C2 PPA2 RP11-864G5.3 SH2B3 SLC25A37 SUOX TBC1D12 TEAD3 ZBTB38 ZNF76
Exposure to tobacco smoke outside home 1.50 2 0 0.0 0.00 1.0e+00 NT5C2 SH2B3
Worry too long after embarrassment 1.16 1 0 0.0 0.00 1.0e+00 PPA2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.57 1 0 0.0 0.00 1.0e+00 GS1-259H13.2
Reason for reducing amount of alcohol drunk: Health precaution 1.49 1 0 0.0 0.00 1.0e+00 SUOX
Age at first live birth 1.47 2 0 0.0 0.00 1.0e+00 GS1-259H13.2 PTK2
Pulse wave peak to peak time 2.07 1 0 0.0 0.00 1.0e+00 NT5C2
Qualifications: College or University degree 2.06 6 4 12.1 0.72 1.1e-01 DCAF16 PPA2 PTK2 RP11-864G5.3 SUOX ZBTB38
Medication for pain relief, constipation, heartburn 1.90 1 0 0.0 0.00 1.0e+00 PTK2
Neck or shoulder pain in last month 1.60 2 0 0.0 0.00 1.0e+00 PTK2 SUOX
Medication: Blood pressure 5.46 6 3 9.1 -0.79 3.4e-02 CLCN6 DCAF16 FES GABARAP MPI SH2B3
Angina (self-reported) 2.16 1 1 3.0 0.00 1.0e+00 FES
Medication: Allopurinol 1.30 1 0 0.0 0.00 1.0e+00 SH2B3
Mean time to correctly identify matches 2.03 2 1 3.0 0.00 1.0e+00 FES SH2B3
Whole body fat mass 2.13 8 2 6.1 0.29 4.8e-01 ADCY5 ANAPC10 CLCN6 GS1-259H13.2 MPI NT5C2 SLC25A37 ZBTB38
Leg fat mass (right) 2.01 8 4 12.1 0.20 6.3e-01 ADCY5 CLCN6 GS1-259H13.2 MPI NT5C2 SLC25A37 SUOX ZBTB38
Arm predicted mass (right) 5.27 16 9 27.3 0.62 1.1e-02 ADAM17 ADCY5 ANAPC10 DCAF16 GJC3 IPO8 NT5C2 PPA2 RP11-864G5.3 SH2B3 SLC25A37 SUOX TBC1D12 TEAD3 ZBTB38 ZNF76
Pulse rate, automated reading 2.15 5 3 9.1 0.80 1.1e-01 E2F6 RP11-864G5.3 SUOX ZBTB38 ZKSCAN5
Alcohol intake frequency. 1.28 2 0 0.0 0.00 1.0e+00 PPA2 SUOX
Comparative height size at age 10 5.67 13 8 24.2 0.82 6.4e-04 ADAM17 ANAPC10 DCAF16 DCXR FES IPO8 NT5C2 PPA2 PREX1 SH2B3 TEAD3 ZBTB38 ZNF76
Suffer from 'nerves' 1.29 1 0 0.0 0.00 1.0e+00 NT5C2
Overall health rating 1.11 1 0 0.0 0.00 1.0e+00 SUOX
Medication: Aspirin 2.00 2 1 3.0 0.00 1.0e+00 FES SH2B3
Knee pain experienced in last month 2.01 2 0 0.0 0.00 1.0e+00 NOC3L PTK2
Hypertension (Self-reported) 6.21 9 5 15.2 -0.94 3.9e-05 CLCN6 DCAF16 FES MPI PTK2 SH2B3 SLC25A37 SUOX TBC1D12
Illnesses of father: Heart disease 2.94 2 1 3.0 0.00 1.0e+00 FES SH2B3
Smoking status: Previous 1.84 2 0 0.0 0.00 1.0e+00 SH2B3 SUOX
Forced expiratory volume in 1-second (FEV1), predicted 5.71 7 4 12.1 0.97 3.4e-04 ANAPC10 DCAF16 NT5C2 PPA2 TEAD3 ZBTB38 ZNF76
Whole body fat-free mass 5.62 16 8 24.2 0.74 1.0e-03 ADAM17 ANAPC10 DCAF16 GJC3 IPO8 NOC3L NT5C2 PPA2 PTK2 SH2B3 SLC25A37 SUOX TBC1D12 TEAD3 ZBTB38 ZNF76
Leg fat-free mass (right) 4.65 15 5 15.2 0.72 2.6e-03 ANAPC10 DCAF16 FES IPO8 NOC3L NT5C2 PPA2 PTK2 SH2B3 SLC25A37 SUOX TBC1D12 TEAD3 ZBTB38 ZNF76
Arm fat percentage (left) 1.69 8 2 6.1 -0.49 2.2e-01 CLCN6 DCAF16 GS1-259H13.2 MPI PREX1 SLC25A37 TEAD3 ZNF76
Average weekly red wine intake 1.14 1 0 0.0 0.00 1.0e+00 MPI
Mood swings 1.60 1 1 3.0 0.00 1.0e+00 PTK2
Loneliness, isolation 1.67 1 0 0.0 0.00 1.0e+00 SH2B3
Qualifications: nursing, teaching 1.25 1 0 0.0 0.00 1.0e+00 PPA2
Mouth/teeth dental problems: Mouth ulcers 1.26 2 0 0.0 0.00 1.0e+00 PREX1 SH2B3
Medication for cholesterol 2.07 2 1 3.0 0.00 1.0e+00 FES SH2B3
Back pain experienced in last month 2.52 1 0 0.0 0.00 1.0e+00 PTK2
Mineral and other dietary supplements 1.34 1 0 0.0 0.00 1.0e+00 ZKSCAN5
Asthma (self-reported) 2.73 4 2 6.1 0.54 4.6e-01 CLCN6 SUOX ZBTB38 ZNF76
Osteoarthritis (self-reported) 1.42 2 0 0.0 0.00 1.0e+00 MPI PTK2
Medication: Aspirin 2.00 1 1 3.0 0.00 1.0e+00 FES
Illnesses of father: None of the above (group 1) 2.87 2 1 3.0 0.00 1.0e+00 FES SH2B3
Smoking status: Current 1.97 1 1 3.0 0.00 1.0e+00 NT5C2
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.68 5 2 6.1 0.98 4.2e-03 ANAPC10 IPO8 PPA2 TEAD3 ZNF76
Whole body water mass 5.57 16 8 24.2 0.74 1.1e-03 ADAM17 ANAPC10 DCAF16 GJC3 IPO8 NOC3L NT5C2 PPA2 PTK2 SH2B3 SLC25A37 SUOX TBC1D12 TEAD3 ZBTB38 ZNF76
Leg predicted mass (right) 4.68 15 5 15.2 0.72 2.5e-03 ANAPC10 DCAF16 FES IPO8 NOC3L NT5C2 PPA2 PTK2 SH2B3 SLC25A37 SUOX TBC1D12 TEAD3 ZBTB38 ZNF76
Arm fat mass (left) 1.81 9 2 6.1 0.20 6.0e-01 ADCY5 ANAPC10 CLCN6 GS1-259H13.2 MPI NT5C2 SLC25A37 SUOX ZBTB38
Number of self-reported non-cancer illnesses 2.64 3 1 3.0 0.00 1.0e+00 CLCN6 SH2B3 ZNF76
Average weekly champagne plus white wine intake 2.16 3 0 0.0 0.00 1.0e+00 DCXR RP11-864G5.3 SUOX
Hearing aid user 1.03 1 0 0.0 0.00 1.0e+00 PTK2
Medication: Blood pressure 3.97 4 4 12.1 -0.99 1.9e-03 CLCN6 FES MPI SH2B3
High cholesterol (Self-reported) 1.59 1 0 0.0 0.00 1.0e+00 FES
Medication: Bendroflumethiazide 2.75 3 1 3.0 0.00 1.0e+00 FES MPI SH2B3
Medication: Paracetamol 1.83 1 0 0.0 0.00 1.0e+00 PTK2
Medication: Lisinopril 2.12 1 0 0.0 0.00 1.0e+00 SH2B3
Illnesses of father: High blood pressure 3.58 3 1 3.0 0.00 1.0e+00 CLCN6 FES SH2B3
Ever smoked 2.34 4 1 3.0 -0.24 7.6e-01 GS1-259H13.2 NT5C2 PPA2 SH2B3
Basal metabolic rate 5.17 15 7 21.2 0.62 1.4e-02 ADAM17 ADCY5 ANAPC10 DCAF16 IPO8 NT5C2 PPA2 RP11-864G5.3 SH2B3 SLC25A37 SUOX TBC1D12 TEAD3 ZBTB38 ZNF76
Leg fat percentage (left) 2.14 9 3 9.1 -0.49 1.8e-01 CLCN6 DCAF16 GS1-259H13.2 MPI PREX1 SLC25A37 TBC1D12 TEAD3 ZNF76
Arm fat-free mass (left) 5.21 15 9 27.3 0.62 1.4e-02 ADAM17 ADCY5 ANAPC10 DCAF16 GJC3 IPO8 NT5C2 PPA2 RP11-864G5.3 SH2B3 SLC25A37 SUOX TEAD3 ZBTB38 ZNF76
Number of operations (self-reported) 2.30 2 1 3.0 0.00 1.0e+00 PPA2 SCNN1D
Ever had prostate specific antigen (PSA) test 1.49 1 0 0.0 0.00 1.0e+00 ZBTB38
Age started oral contraceptive pill 1.51 1 0 0.0 0.00 1.0e+00 SUOX
Diastolic blood pressure, automated reading 6.23 9 4 12.1 -0.78 8.1e-03 CLCN6 DCAF16 FES MPI NOC3L SH2B3 SLC25A37 TBC1D12 ZNF76
Vascular/heart problems diagnosed by doctor 6.31 9 4 12.1 0.94 5.3e-05 CLCN6 DCAF16 FES MPI PTK2 SH2B3 SUOX TBC1D12 TEAD3
Pain experienced in last month 1.94 3 0 0.0 0.00 1.0e+00 PTK2 SH2B3 SUOX
Heart attack/myocardial infarction (self-reported) 2.37 3 1 3.0 0.00 1.0e+00 FES SH2B3 TEAD3
Deep venous thrombosis (DVT) (self-reported) 1.08 1 0 0.0 0.00 1.0e+00 SH2B3
Heart disease (siblings) 1.89 1 0 0.0 0.00 1.0e+00 FES
Pack years of smoking 1.72 1 0 0.0 0.00 1.0e+00 GS1-259H13.2
Impedance of whole body 1.43 5 3 9.1 -0.14 8.2e-01 NT5C2 PPA2 PTK2 SUOX TBC1D12
Leg fat mass (left) 2.04 8 4 12.1 0.20 6.4e-01 ADCY5 CLCN6 GS1-259H13.2 MPI NT5C2 SLC25A37 SUOX ZBTB38
Arm predicted mass (left) 5.22 16 8 24.2 0.62 1.1e-02 ADAM17 ADCY5 ANAPC10 DCAF16 GJC3 IPO8 NT5C2 PPA2 RP11-864G5.3 SH2B3 SLC25A37 SUOX TBC1D12 TEAD3 ZBTB38 ZNF76

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 6 0.1719 1.88
GTEx Adipose Visceral Omentum 3 0.1473 1.90
GTEx Adrenal Gland 2 0.1373 1.76
GTEx Artery Aorta 4 0.1344 1.90
GTEx Artery Coronary 1 0.0845 1.85
GTEx Artery Tibial 10 0.2659 1.98
GTEx Brain Caudate basal ganglia 1 0.1087 1.78
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.91
GTEx Brain Cerebellum 3 0.1514 1.88
GTEx Brain Cortex 1 0.0966 1.80
GTEx Brain Frontal Cortex BA9 0 0.0000 1.77
GTEx Brain Hippocampus 0 0.0000 1.75
GTEx Brain Hypothalamus 1 0.1695 1.78
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.81
GTEx Brain Putamen basal ganglia 0 0.0000 1.59
GTEx Breast Mammary Tissue 2 0.1013 1.83
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.85
GTEx Breast Mammary Tissue (Female) 3 0.1825 1.84
GTEx Cells EBV-transformed lymphocytes 3 0.2108 1.93
GTEx Cells Transformed fibroblasts 5 0.1191 1.86
GTEx Colon Sigmoid 1 0.0684 1.94
GTEx Colon Transverse 2 0.0969 1.80
GTEx Esophagus Gastroesophageal Junction 1 0.0692 1.94
GTEx Esophagus Mucosa 5 0.1506 1.86
GTEx Esophagus Muscularis 4 0.1238 1.90
GTEx Heart Atrial Appendage 3 0.1900 1.82
GTEx Heart Left Ventricle 2 0.1307 1.79
GTEx Liver 0 0.0000 1.76
GTEx Lung 6 0.2088 1.85
GTEx Muscle Skeletal 1 0.0346 1.85
GTEx Nerve Tibial 9 0.2083 1.84
GTEx Ovary 1 0.1101 1.90
GTEx Pancreas 1 0.0613 1.84
GTEx Pituitary 0 0.0000 2.03
GTEx Prostate 1 0.1198 1.84
GTEx Skin Not Sun Exposed Suprapubic 4 0.1627 1.87
GTEx Skin Sun Exposed Lower leg 6 0.1648 1.92
GTEx Small Intestine Terminal Ileum 0 0.0000 1.82
GTEx Spleen 3 0.2126 1.82
GTEx Stomach 2 0.1376 1.96
GTEx Testis 2 0.0634 1.84
GTEx Thyroid 3 0.0750 1.81
GTEx Uterus 1 0.1764 1.99
GTEx Vagina 0 0.0000 1.95
GTEx Whole Blood 1 0.0502 1.78
METSIM Adipose 7 0.1518 1.79
NTR Blood 3 0.1249 1.90
ROSMAP Brain Pre-frontal Cortex 3 0.0683 1.82
YFS Blood 6 0.1299 1.77
CommonMind Brain Pre-frontal Cortex 10 0.1860 1.77
TCGA Breast Tumor 0 0.0000 1.92
TCGA Breast Normal 6 0.1426 1.73
TCGA Ovarian Tumor 2 0.0684 1.59
TCGA Prostate Tumor 6 0.1735 1.81