Hub : Genes

E2F6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0530	0.0230	1.4e-02	0.003	0.019	-0.002	0.019	-0.002	1.3e-01	1.9e-03	7.6e-01	0.00170	8.3e-01
2	GTEx	Heart Left Ventricle	0.2104	0.0600	3.6e-04	0.073	NA	0.028	NA	0.067	1.0e-04	NA	1.2e-02	NA	2.0e-04
3	ROSMAP	Brain Pre-frontal Cortex	0.0455	0.0181	7.8e-03	0.032	0.020	0.022	0.022	0.017	5.4e-05	1.1e-03	7.2e-04	0.00072	2.2e-03
4	TCGA	Breast Invasive Carcinoma	0.0226	0.0098	3.3e-06	0.029	0.025	0.029	NA	0.026	9.1e-07	5.7e-06	8.5e-07	NA	3.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.9	1.0	0.3	0.2	0.0
Bipolar Disorder or Schizophrenia	0.3	0.7	1.3	1.1	0.7	0.9	-0.4
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	0.8	0.4	1.3	-0.5
Depression (Nagel 2018)	0.1	0.2	0.8	-0.1	0.1	-0.9	-0.3
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.5	-1.2	-0.8	-0.9	0.5
Neuroticism (Nagel 2018)	0.4	0.9	1.8	0.4	0.8	1.4	-0.9
Schizophrenia (2018)	0.3	0.6	1.2	0.6	0.7	1.1	-0.5
Schizophrenia vs Biploar Disorder	0.3	0.5	0.7	0.1	0.9	0.8	-0.7
Worry (Nagel 2018)	0.1	0.2	0.3	0.3	0.4	0.6	-0.3
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	1.0	-0.1	0.6	-0.3
Alzheimer’s Disease (in father)	0.8	0.9	3.6	1.9	0.1	0.1	0.0
Alzheimer’s Disease (including proxy)	0.5	0.8	2.9	1.7	-0.4	-0.1	-0.0
Crohns Disease (2017)	1.0	2.3	4.2	1.4	2.0	0.8	-1.6
Irritable Bowel Disease (IBD)	0.5	1.1	2.3	1.5	1.0	-0.1	-0.9
Ulcerative Colitis (UC)	0.6	1.0	2.4	1.2	-0.5	-1.6	0.2
Major Depression (MDD)	0.1	0.1	0.2	-0.1	0.3	0.4	-0.0
Reaction Time	0.2	0.5	0.7	-0.7	-0.8	0.3	0.8
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.5	-1.9	0.1	-0.2	-0.2
Breast Cancer	0.1	0.3	0.5	0.6	-0.4	0.7	0.3
Ovarian Cancer	0.5	0.6	1.1	0.9	-0.7	1.1	0.4
Prostate Cancer	1.3	1.9	5.6	2.4	-0.5	1.2	-0.3
Age at First Birth	0.4	0.5	1.8	-1.3	0.2	-0.4	-0.2
Bipolar Disorder (2011)	1.2	1.2	3.5	0.0	-1.1	-1.9	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.9	0.2	-0.7	-1.4	0.3
Coronary Artery Disease (CAD)	0.4	0.5	1.6	1.3	0.2	0.5	-0.5
Crohns Disease (2012)	0.3	0.5	1.0	1.0	0.6	-0.8	0.0
Mean Putamen Volume	1.0	1.2	3.5	-1.9	0.6	-0.9	-0.3
Fasting Glucose	1.4	1.6	2.2	1.5	0.9	1.3	-1.3
HbA1C	0.4	0.4	0.9	0.7	0.5	-0.4	-0.9
HDL Cholesterol	0.2	0.3	0.6	-0.4	0.5	0.8	-0.6
LDL Cholesterol	0.6	1.0	1.3	-1.1	-1.1	-0.5	1.1
Lupus	0.4	0.6	1.3	-0.3	-1.1	-0.1	1.1
Neuroticism (2016)	1.1	1.6	2.3	1.5	1.1	1.2	-1.2
Primary Biliary Cirrhosis	0.5	0.7	2.0	0.1	-0.6	-1.4	0.6
Rheumatoid Arthritis	0.7	1.0	2.2	-0.5	0.6	1.5	-1.0
Schizophrenia (2014)	0.3	0.6	1.6	0.5	0.5	1.3	-0.4
Triglycerides	0.2	0.3	0.7	-0.9	-0.1	-0.7	0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.9	1.4	0.2	-0.2	-0.6
Ulcerative Colitis	0.8	1.2	2.9	0.7	-0.7	-1.7	0.9
Blood Eosinophil Count	0.1	0.4	0.8	-0.5	-0.9	-0.2	0.8
Blood Platelet Count	0.2	2.0	7.4	-2.7	-0.8	0.1	0.0
Blood Red Count	0.1	0.9	1.6	1.3	-1.2	0.4	0.8
Blood White Count	0.3	2.3	3.6	1.9	1.4	-0.2	-1.9
Heel T-Score	1.0	8.3	13.6	2.3	2.8	3.7	-2.5
BMI	0.3	2.0	4.6	1.1	1.4	-0.2	-2.1
Height	0.1	2.0	3.3	1.1	-1.8	0.9	1.6
Waist Hip Ratio (WHR)	0.2	1.0	3.2	-0.3	0.4	1.8	-0.7
Systolic Blood Pressure	1.8	9.1	19.9	2.2	2.7	4.5	-2.0
Smoking Status	0.2	0.4	1.4	0.0	0.0	1.2	-0.5
Allergy or Eczema	0.9	2.4	7.2	-0.7	-1.1	-2.7	0.7
Cardiovascular Disease	3.0	9.8	14.0	1.9	3.4	3.7	-3.2
Hypothyroidism (self reported)	1.4	3.1	6.4	-2.5	-1.4	-1.6	1.2
Respiratory disease	0.4	0.9	2.7	1.6	0.4	0.3	-0.8
Type 2 Diabetes (T2D) (2018)	2.9	5.4	6.7	2.0	2.4	2.2	-2.6
Lung FEV1/FVC ratio	0.5	2.4	3.6	-1.3	1.0	1.9	-1.8
Lung FVC	0.1	0.6	1.0	-0.4	-1.0	-0.9	0.8
Neuroticism	0.9	2.2	5.9	0.7	1.1	2.4	-1.1
Chronotype (morning person)	0.0	0.0	0.1	0.0	0.0	-0.3	0.2
Hair Pigment	0.2	6.2	7.7	2.2	2.5	2.5	-2.8
Tanning	0.1	0.9	2.8	-0.7	0.3	1.7	-0.4
Hand grip strength (left)	0.1	0.2	0.9	0.9	0.1	-0.2	-0.2
Number of treatments/medications taken	0.3	0.6	1.0	-1.0	-0.5	-0.7	0.7
Average weekly spirits intake	0.4	0.5	1.1	-1.0	-1.0	-0.1	0.1
Sensitivity / hurt feelings	0.7	1.2	2.2	-0.4	1.5	1.3	-1.0
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.7	0.1	-0.5	-1.3	-0.0
Hearing difficulty/problems: Yes	2.2	3.3	9.8	-3.1	-1.4	-0.5	1.1
Relative age of first facial hair	0.8	1.7	3.6	-1.9	-1.1	-0.9	0.9
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	4.8	-2.2	-0.8	-0.4	1.0
Ever used hormone-replacement therapy (HRT)	1.9	2.5	6.0	-2.4	-1.4	-1.1	0.8
Ever had hysterectomy (womb removed)	2.1	2.3	2.6	-1.5	-1.4	-1.6	1.6
Systolic blood pressure, automated reading	1.0	2.8	3.9	1.0	1.9	2.0	-1.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	0.6	0.1	-0.2	-0.1
Angina	0.4	0.6	1.4	-1.2	-0.2	0.8	-0.2
Medication for hormone replacement therapy	2.3	2.5	7.8	-2.8	-1.0	-0.5	1.0
Vitamin and mineral supplements	0.0	0.0	0.0	0.0	-0.1	-0.2	0.0
Supplements: Zinc	0.4	0.4	0.5	0.7	0.7	0.6	-0.5
Medication: Co-codamol	2.6	3.0	4.3	1.8	2.1	0.7	-2.0
Medication: Metformin	0.8	1.1	1.9	-0.2	1.0	1.4	-1.3
Diabetes (father)	0.7	0.9	1.9	-0.4	-0.9	-0.9	1.4
Diabetes (mother)	0.3	0.4	0.6	0.8	-0.4	-0.1	0.8
Severe depression (siblings)	0.6	0.7	2.3	1.5	0.4	-0.2	-0.4
Pack years adult smoking proportion	0.2	0.4	0.7	0.4	-0.1	-0.8	0.8
Impedance of leg (right)	1.0	5.1	6.1	-2.2	-2.2	-2.5	2.1
Leg fat-free mass (left)	0.2	1.3	3.6	1.9	0.7	0.6	-0.7
Trunk fat percentage	0.7	2.7	6.8	-1.5	-1.2	-2.6	0.6
Hand grip strength (right)	0.5	1.3	2.2	1.5	0.6	1.1	-1.2
Townsend deprivation index at recruitment	0.8	1.1	3.2	-1.8	-0.6	-0.7	0.4
Current tobacco smoking	0.4	0.7	1.0	-1.0	-0.9	0.5	0.9
Average weekly fortified wine intake	0.9	1.0	3.2	-1.8	-0.4	-0.9	-0.1
Maternal smoking around birth	0.2	0.3	0.8	0.2	-0.4	-0.9	0.5
Fed-up feelings	0.2	0.4	1.1	-1.0	-0.4	-0.6	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.4	-1.0	-0.7	-1.2	-0.2
Relative age voice broke	1.6	2.5	3.8	-1.9	-1.4	-1.4	1.5
Taking other prescription medications	1.3	2.1	5.8	-2.4	-0.8	-1.2	0.5
Age when periods started (menarche)	4.4	10.5	11.9	-3.0	-3.4	-3.4	3.1
Bilateral oophorectomy (both ovaries removed)	4.5	5.2	8.3	-2.6	-1.3	-2.9	2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	3.6	1.4	1.4	1.9	-1.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.7	-1.3	-0.0	-0.3	0.6
Qualifications: CSEs or equivalent	2.7	3.6	3.9	-1.9	-2.0	-1.9	1.7
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.3	-0.5	-0.0	0.2
High blood pressure	1.0	2.8	4.2	0.8	1.9	2.0	-1.7
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.7	-0.3	-0.4	-1.3	-0.3
Multivitamins +/- minerals	0.4	0.6	1.5	-0.5	0.4	1.2	-0.5
Stomach or abdominal pain in last month	1.1	1.4	3.4	-1.0	-0.9	-1.8	0.6
Supplements: Glucosamine	0.1	0.2	0.5	-0.7	0.1	0.4	-0.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	-1.0	-0.3	0.7	0.6
Medication: Atenolol	1.2	1.5	3.3	0.8	1.2	1.8	-0.8
Medication: Levothyroxine sodium	1.1	1.9	5.1	-2.2	-1.2	-0.7	0.9
Sitting height	0.5	3.5	9.2	3.0	0.5	2.1	-0.4
Chronic bronchitis/emphysema (father)	1.0	1.2	2.2	-0.6	-1.3	-1.5	0.7
High blood pressure (mother)	1.1	1.6	3.0	0.7	1.2	1.7	-1.1
Body mass index (BMI)	0.1	0.6	1.2	1.0	0.5	-0.4	-1.1
Impedance of leg (left)	1.4	6.6	8.2	-2.9	-2.6	-2.4	2.4
Leg predicted mass (left)	0.2	1.2	3.4	1.9	0.8	0.6	-0.7
Trunk fat mass	0.3	1.3	3.6	-0.6	-1.0	-1.9	0.4
Waist circumference	0.0	0.2	0.4	0.3	-0.4	-0.6	-0.1
Number of incorrect matches in round	0.0	0.1	0.1	0.3	-0.1	-0.3	0.3
Past tobacco smoking	1.0	1.8	3.7	0.1	-1.0	-1.6	1.9
Alcohol usually taken with meals	0.5	0.8	1.7	1.3	-0.5	-0.9	0.6
Nervous feelings	0.2	0.3	1.1	-1.0	0.0	0.4	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.6	0.8	-1.2	0.8	0.4
Hearing difficulty/problems with background noise	1.3	2.0	7.1	-2.7	-0.8	-0.1	0.5
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	-0.2	-0.8	-0.2	0.8
Had menopause	1.4	1.7	3.1	-1.0	-1.8	-1.0	1.4
Had other major operations	1.7	2.1	7.0	-2.6	-1.0	0.2	0.5
Forced vital capacity (FVC)	0.2	1.0	2.5	1.6	-1.0	-0.2	0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	6.1	1.2	1.2	2.5	-1.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.4	-0.2	0.4	0.0
Qualifications: None of the above	0.5	1.0	2.9	-0.6	-0.5	-1.7	0.7
Financial difficulties in last 2 years	0.8	1.0	1.4	1.0	0.8	1.2	-1.0
Mouth/teeth dental problems	0.5	0.8	2.0	1.4	0.2	-1.0	0.4
Heart attack	0.7	0.8	1.8	-0.3	0.8	1.4	-0.9
Allergy	0.1	0.2	0.6	0.1	-0.1	0.4	0.8
Pain all over the body in last month	0.2	0.2	0.8	-0.9	0.1	0.1	-0.4
Diabetes (self-reported)	1.1	1.7	2.6	0.5	1.5	1.3	-1.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.3	0.3	-0.5	-0.4
Medication: Ramipril	0.2	0.2	0.4	-0.6	0.2	0.6	-0.4
Medication: Simvastatin	0.6	0.8	1.1	-1.0	1.0	0.5	-1.0
Fluid intelligence score	0.2	0.4	0.5	-0.7	0.6	-0.1	-0.7
Illnesses of siblings	0.5	0.7	1.1	-0.4	-0.8	-0.9	1.0
Neuroticism score	0.4	0.7	2.2	0.0	0.5	1.5	-0.7
Weight	0.1	0.4	1.3	1.2	-0.3	-0.5	-0.2
Impedance of arm (right)	1.4	6.6	10.0	-3.2	-1.8	-3.0	2.0
Arm fat percentage (right)	0.3	1.4	5.1	-0.4	-0.1	-2.3	-0.4
Trunk fat-free mass	0.4	2.3	6.1	2.5	0.4	1.7	-0.2
Hip circumference	0.6	2.8	6.1	-0.4	-1.7	-2.5	1.4
Time employed in main current job	1.2	1.4	2.5	1.3	1.6	0.9	-0.8
Alcohol intake versus 10 years previously	1.2	1.8	4.5	1.1	0.9	2.1	-0.8
Father’s age at death	0.8	1.1	1.6	-1.3	-1.0	-0.8	1.0
Worrier / anxious feelings	0.1	0.2	0.6	-0.4	-0.3	0.7	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.2	-0.1	-1.8	-0.1	1.5
Falls in the last year	1.6	2.2	2.9	1.6	1.3	1.7	-1.2
Hair/balding pattern: Pattern 3	0.4	0.6	2.0	1.4	0.3	-0.0	-0.5
Number of live births	1.2	1.6	2.6	1.0	0.9	1.4	-1.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.1	1.0	-0.5	0.0	0.2
Pulse rate	1.1	1.8	3.4	1.0	-1.6	0.1	1.8
Happiness	0.2	0.3	0.7	0.2	0.3	0.8	-0.5
Noisy workplace	1.0	1.2	3.1	-0.3	-0.9	-1.8	1.0
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	0.6	-0.4	-0.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.6	0.8	0.0	0.0	-0.0
Mouth/teeth dental problems: Dentures	0.2	0.4	1.2	-1.1	-0.3	-0.2	-0.4
Asthma	0.5	1.0	1.6	1.3	0.7	0.5	-1.2
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.2	4.5	1.0	1.9	2.1	-2.0
Medication: Cholesterol lowering	0.5	0.8	1.5	-0.4	0.8	1.2	-1.1
Depression (self-reported)	0.4	0.5	1.7	0.0	-0.5	-1.3	0.4
Medication: Lansoprazole	0.8	0.9	1.3	-0.4	-0.9	-1.1	1.1
Prospective memory result	0.1	0.1	0.1	-0.0	-0.4	0.3	0.4
Lung cancer (father)	0.8	0.9	2.1	0.9	0.8	0.0	-1.4
Illnesses of mother	1.0	1.3	2.7	-1.1	-0.9	-1.7	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.8	0.7	-0.9	-0.1	0.3
Pulse wave Arterial Stiffness index	0.6	0.7	2.8	1.7	0.2	-0.1	-0.3
Impedance of arm (left)	1.0	4.8	7.8	-2.8	-1.6	-2.4	1.8
Arm fat mass (right)	0.2	0.6	2.0	0.5	-0.0	-1.4	-0.5
Trunk predicted mass	0.4	2.1	5.5	2.4	0.3	1.7	-0.1
Standing height	0.1	1.4	2.9	0.5	-1.5	0.2	1.7
Length of working week for main job	0.8	0.9	1.4	0.6	1.2	0.7	-1.1
Exposure to tobacco smoke at home	0.6	0.7	2.5	0.1	0.4	-1.6	-0.2
Breastfed as a baby	0.4	0.5	0.9	-0.8	-0.6	-1.0	-0.0
Tense / ‘highly strung’	0.1	0.2	0.4	-0.7	-0.6	0.4	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.2	0.3	0.1	-0.7
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	-0.4	0.6	0.2	-1.0
Birth weight of first child	10.1	18.3	29.8	-1.7	-5.5	-3.6	5.2
Peak expiratory flow (PEF)	0.1	0.2	0.5	0.7	-0.1	0.4	-0.4
Pulse wave reflection index	0.4	0.5	0.7	0.8	0.6	-0.8	-0.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.0	-0.9	-0.3	1.4	-0.1
Loud music exposure frequency	0.5	0.5	1.2	1.1	0.4	0.8	-0.5
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.9	-0.0	-1.4	-1.2	0.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.6	-0.6	0.3	0.3
Blood clot in the leg (DVT)	0.8	1.0	1.8	0.7	1.4	0.5	-1.2
Medication: Paracetamol	0.8	1.3	3.2	-1.8	-0.4	-1.4	0.3
Headache pain in last month	0.3	0.6	1.1	-1.0	-0.4	-0.8	0.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	3.2	-0.3	-1.0	-1.8	1.2
Glaucoma (self-reported)	0.3	0.4	1.2	-1.1	-0.5	-0.1	-0.3
Gout (self-reported)	0.1	0.2	0.5	-0.1	-0.3	-0.7	0.4
Hypothyroidism/myxoedema (self-reported)	1.9	3.8	5.6	-2.4	-1.9	-1.8	1.5
Medication: Amlodipine	0.7	1.0	3.2	0.2	0.6	1.8	-0.5
Medication: Ventolin 100micrograms inhaler	1.5	2.0	3.9	2.0	1.0	0.9	-1.5
Birth weight	1.4	3.0	4.2	-1.6	-2.0	-1.2	2.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.4	-0.7	-1.2	-0.3	0.7
High blood pressure (siblings)	1.5	2.1	3.2	1.8	1.5	1.2	-1.2
Forced vital capacity (FVC), Best measure	0.2	0.7	1.3	1.1	-1.2	0.3	0.4
Body fat percentage	0.7	2.6	7.8	-1.2	-1.1	-2.8	0.4
Leg fat percentage (right)	0.9	3.1	9.1	-1.1	-1.3	-3.0	0.7
Arm fat-free mass (right)	0.3	1.6	4.4	2.1	0.2	1.4	-0.3
Exposure to tobacco smoke outside home	0.5	0.7	2.2	-1.5	-0.1	-0.7	0.4
Comparative body size at age 10	0.1	0.3	0.6	0.3	-0.6	0.8	0.2
Number of full brothers	0.1	0.1	0.2	0.5	0.4	-0.1	0.1
Worry too long after embarrassment	0.7	1.2	3.2	-1.8	-1.1	-0.5	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.3	-0.1	-0.3	0.1
Wheeze or whistling in the chest in last year	0.5	0.9	2.0	1.4	0.6	0.7	-0.8
Number of children fathered	0.1	0.1	0.3	0.2	-0.5	-0.1	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	-0.7	0.1	-0.7	-0.2
Age at first live birth	0.7	1.2	2.1	0.5	1.3	1.4	-1.0
Pulse wave peak to peak time	0.5	0.6	2.3	-1.5	-0.2	0.3	0.3
Health satisfaction	0.4	0.5	1.0	-0.9	0.3	-0.0	-1.0
Shortness of breath walking on level ground	1.0	1.2	3.3	-1.8	-0.6	-0.9	0.3
Qualifications: College or University degree	0.9	3.0	5.4	2.2	0.9	2.3	-1.0
Eye problems/disorders: None of the above	0.2	0.3	0.7	-0.0	-0.3	0.8	0.6
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.5	1.9	1.0	0.7	-0.8
Emphysema/chronic bronchitis	0.1	0.2	0.4	0.6	0.3	0.2	-0.4
Medication for pain relief, constipation, heartburn	0.6	1.0	1.8	0.2	-0.9	-1.3	1.1
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.2	-0.5	0.3	-0.3
Medication: Blood pressure	1.1	1.9	3.1	0.1	1.5	1.8	-1.6
Angina (self-reported)	0.5	0.7	1.4	-1.1	-0.0	1.2	-0.4
Migraine (self-reported)	0.8	1.0	2.2	0.7	0.8	-0.9	-1.5
Medication: Ibuprofen	1.7	2.0	2.9	0.7	1.6	1.7	-1.5
Medication: Allopurinol	0.1	0.2	0.5	0.2	-0.0	-0.7	-0.3
Medication: Omeprazole	0.7	0.8	1.5	-1.2	-1.2	-0.1	0.6
Medication: Seretide 50 evohaler	3.6	4.2	6.5	2.5	1.8	2.2	-1.4
Mean time to correctly identify matches	0.3	0.6	0.9	-1.0	-0.8	0.4	0.7
Heart disease (mother)	2.3	2.8	5.3	0.3	1.9	2.3	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.1
Whole body fat mass	0.2	1.0	3.7	-0.1	-0.6	-1.9	0.1
Leg fat mass (right)	0.3	1.1	4.1	-0.0	-0.6	-2.0	-0.0
Arm predicted mass (right)	0.2	1.0	2.5	1.6	-0.0	1.1	-0.2
Pulse rate, automated reading	2.0	6.6	14.0	-0.9	-3.7	-1.2	3.1
Alcohol intake frequency.	0.3	0.6	2.0	1.4	0.3	0.5	0.3
Comparative height size at age 10	0.3	1.4	3.7	1.9	0.1	1.4	0.3
Number of full sisters	0.3	0.3	1.0	-1.0	-0.5	0.3	-0.0
Suffer from ‘nerves’	0.1	0.1	0.2	0.3	0.4	0.2	-0.4
Overall health rating	0.5	1.0	3.1	-1.8	-0.1	-1.0	-0.3
Chest pain or discomfort	0.8	1.1	1.9	-0.6	-1.4	-1.1	1.1
Had major operations	0.1	0.1	0.2	-0.3	-0.4	-0.1	-0.2
Age at last live birth	1.8	2.5	3.4	1.9	1.5	1.4	-1.6
Family relationship satisfaction	1.7	2.1	2.4	1.5	1.2	1.4	-1.6
Leg pain on walking	1.1	1.4	2.4	-1.3	-0.9	-1.5	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.0	-0.1	0.7	-1.0	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	-0.5	-0.2	-0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.7	-0.9	-0.8	-0.6	0.3
Medication: Aspirin	0.7	1.0	1.5	0.3	1.1	1.2	-1.1
Supplements: Vitamin C	0.2	0.3	1.0	0.0	-0.1	-1.0	-0.1
Knee pain experienced in last month	0.2	0.3	0.7	0.7	0.1	-0.1	-0.8
Hypertension (Self-reported)	1.4	3.9	5.6	1.1	2.2	2.4	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.9	2.2	-0.0	0.5	-0.4
Illnesses of father: Heart disease	1.1	1.5	2.3	1.0	0.8	1.5	-1.5
Illnesses of siblings: Diabetes	2.3	2.9	4.3	-2.1	-2.0	-0.2	1.8
Smoking status: Previous	1.2	1.8	3.3	-0.1	1.1	1.7	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	6.4	-0.4	-2.5	-0.9	2.1
Whole body fat-free mass	0.3	1.6	4.6	2.1	0.4	1.3	-0.3
Leg fat-free mass (right)	0.3	1.4	3.2	1.8	0.8	1.1	-0.7
Arm fat percentage (left)	0.3	1.2	4.6	-0.4	-0.2	-2.1	-0.3
Average weekly red wine intake	0.2	0.3	0.6	0.5	0.7	-0.1	-0.8
Handedness (chirality/laterality): Left-handed	2.7	3.3	5.2	-0.7	-1.9	-1.9	2.3
Mood swings	1.0	1.8	2.4	1.1	1.2	1.4	-1.6
Loneliness, isolation	0.2	0.3	0.8	0.4	0.5	0.2	-0.9
Long-standing illness, disability or infirmity	0.1	0.2	0.5	-0.1	0.7	0.3	-0.5
Ever had bowel cancer screening	1.2	1.4	3.1	-1.8	-1.1	-0.8	0.8
Diabetes diagnosed by doctor	1.1	1.8	3.0	0.6	1.4	1.4	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.3	-0.5	-0.3	0.2
Friendships satisfaction	0.3	0.3	0.9	-0.9	0.5	0.2	-0.4
Qualifications: nursing, teaching	0.4	0.6	1.3	0.2	-0.8	1.1	0.7
Commuting to job workplace: Walk	0.7	0.7	1.5	-0.7	-0.8	-0.5	1.2
Eye problems/disorders: Cataract	0.2	0.2	0.6	0.1	0.3	-0.5	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.6	1.9	-1.4	-0.5	0.3	0.1
Medication for cholesterol	1.7	2.6	7.7	2.8	0.7	0.9	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.2	6.1	8.2	-2.9	-2.8	-1.8	2.3
Back pain experienced in last month	0.3	0.4	0.6	-0.7	-0.2	-0.8	0.7
Mineral and other dietary supplements	0.1	0.1	0.3	0.5	0.1	-0.1	-0.2
Breast cancer (self-reported)	0.6	0.7	1.5	-0.8	1.2	0.7	-0.5
Asthma (self-reported)	0.2	0.4	0.9	0.9	0.3	0.2	-0.8
Osteoporosis (self-reported)	0.7	0.9	1.5	-1.2	-0.8	-0.8	0.8
Osteoarthritis (self-reported)	0.5	0.6	1.2	-0.4	0.7	1.1	-0.8
Medication: Aspirin	0.5	0.6	1.3	0.5	0.8	1.1	-0.6
Medication: Gliclazide	0.1	0.1	0.2	0.1	0.0	0.5	0.0
Illnesses of father: None of the above (group 1)	2.1	2.6	3.8	-2.0	-1.4	-1.8	1.2
Smoking status: Current	0.2	0.4	0.5	-0.7	-0.7	0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.7	1.3	0.4	0.4	-0.3
Whole body water mass	0.3	1.8	4.8	2.2	0.5	1.3	-0.5
Leg predicted mass (right)	0.3	1.4	3.4	1.8	0.8	1.1	-0.7
Arm fat mass (left)	0.1	0.6	1.5	0.7	0.1	-1.2	-0.7
Number of self-reported non-cancer illnesses	0.6	1.0	1.7	-0.9	0.5	1.2	-1.3
Average weekly champagne plus white wine intake	0.9	1.3	2.5	0.3	1.6	0.9	-1.3
Miserableness	0.2	0.4	0.9	0.1	-0.9	0.9	0.2
Guilty feelings	0.9	1.3	3.3	0.5	1.0	0.8	-1.8
Wears glasses or contact lenses	1.1	1.2	2.4	-0.4	-1.0	-1.6	1.1
Ever taken oral contraceptive pill	5.7	6.3	9.7	3.0	3.1	1.1	-2.3
Hearing aid user	2.2	2.4	5.1	-2.2	-1.0	-1.3	1.4
Mother’s age at death	0.4	0.5	1.5	-1.2	-0.2	0.4	0.6
Financial situation satisfaction	0.2	0.2	0.4	-0.5	-0.3	-0.7	0.1
Tinnitus: Yes, now most or all of the time	3.8	4.4	6.2	0.3	-2.3	-2.4	2.5
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.6	0.8	0.4	-0.5
Eye problems/disorders: Glaucoma	0.4	0.5	0.8	-0.8	-0.9	-0.6	0.1
Medication: Blood pressure	0.3	0.6	1.0	-0.8	0.8	1.0	-0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.6	-0.6	-0.5	-1.6	0.5
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.5	1.2	0.7	0.7	-0.4
High cholesterol (Self-reported)	0.5	0.8	1.3	-0.7	1.1	0.5	-1.2
Medication: Bendroflumethiazide	0.1	0.1	0.3	0.6	0.2	-0.0	0.2
Medication: Paracetamol	0.3	0.4	0.9	-1.0	0.4	-0.6	-0.6
Medication: Lisinopril	0.8	1.1	3.3	-1.8	-0.1	-0.4	0.9
Medication: Atorvastatin	0.3	0.4	1.3	0.1	0.4	1.1	-0.2
Illnesses of father: High blood pressure	0.9	1.1	1.6	0.8	1.1	1.3	-1.0
Alcohol drinker status: Never	3.0	3.6	8.8	3.0	1.3	1.7	-1.0
Ever smoked	0.4	0.6	1.2	-0.6	0.2	1.0	-1.1
Basal metabolic rate	0.2	1.3	4.3	2.1	0.4	0.8	-0.4
Leg fat percentage (left)	0.9	3.1	7.5	-1.5	-1.5	-2.7	0.8
Arm fat-free mass (left)	0.2	1.0	3.5	1.9	-0.1	0.8	0.0
Number of operations (self-reported)	0.8	1.2	3.7	-1.9	-0.9	-0.2	0.2
Average weekly beer plus cider intake	0.1	0.2	0.5	-0.1	-0.3	-0.7	0.4
Irritability	1.0	1.6	2.7	0.3	1.1	1.6	-1.6
Risk taking	0.7	1.1	2.2	1.0	0.9	1.5	-0.6
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.9	0.5	0.3	1.7	-0.9
Fractured/broken bones in last 5 years	1.0	1.3	3.0	-0.3	-1.7	-0.1	1.5
Age started oral contraceptive pill	0.2	0.2	0.3	-0.5	0.5	0.3	-0.4
Diastolic blood pressure, automated reading	1.3	4.0	8.2	2.9	1.6	1.6	-1.6
Ever depressed for a whole week	0.4	0.4	0.9	0.5	0.5	0.9	-0.7
Unable to work because of sickness or disability	2.4	3.1	4.9	1.5	2.0	1.1	-2.2
Commuting to job workplace: Cycle	0.8	1.0	3.2	-1.8	-0.4	0.5	0.6
Myopia	1.3	1.9	2.9	-0.3	1.7	1.4	-1.6
Vascular/heart problems diagnosed by doctor	0.9	2.5	5.0	-0.7	-1.6	-2.2	1.4
Cholesterol lowering medication	1.2	1.7	4.4	-2.1	-0.5	-1.4	0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.4	-0.6	0.2	-0.1
Pain experienced in last month	0.4	0.7	1.7	0.2	-0.9	-0.4	1.3
Supplements: Calcium	0.8	0.9	1.8	-0.3	-1.3	0.1	1.4
Basal cell carcinoma (self-reported)	0.6	0.7	1.7	0.0	-1.3	-0.4	1.0
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.0	-0.4	0.8	1.4	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.5	0.8	1.2	0.4	-1.1
Heart disease (siblings)	0.2	0.3	0.4	-0.7	0.5	0.1	-0.6
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.1	-0.4	0.1	0.2
Pack years of smoking	0.2	0.3	0.5	0.4	-0.0	-0.7	0.7
Impedance of whole body	1.6	8.1	11.9	-3.5	-2.5	-2.8	2.5
Leg fat mass (left)	0.3	1.1	3.9	-0.2	-0.8	-2.0	0.1
Arm predicted mass (left)	0.2	0.9	2.7	1.6	-0.0	0.9	-0.2