Hub : Traits :

Medication: Cholesterol lowering

125 significantly associated models · 54 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 61510619 63844736 3 1 1.3e-12 2.2e-13 1.0e+00 100 USP1
2 1 108854166 110931112 10 1 4.3e-55 6.7e-56 1.0e+00 100 PSRC1
3 2 20529948 21958745 1 1 1.6e-28 1.1e-29 1.0e+00 100 APOB
4 2 26883355 28568016 4 2 9.9e-11 4.6e-15 1.6e-02 90 FNDC4 NRBP1
5 2 43342098 44759941 1 1 6.0e-08 7.1e-25 8.6e-21 18 ABCG5
6 5 73969058 75594743 3 1 5.6e-11 1.5e-13 7.7e-05 71 COL4A3BP
7 6 159820779 161213047 1 2 5.8e-08 3.3e-18 1.3e-14 22 RP11-288H12.3
8 8 19064892 20521138 1 1 6.4e-11 8.0e-14 1.3e-04 74 LPL
9 8 144294773 145744618 1 1 9.8e-08 3.8e-07 6.0e-01 99 PLEC
10 11 99859184 101559718 2 1 9.0e-08 1.2e-06 6.7e-01 99 TMEM133
11 11 115953897 117800682 4 2 5.4e-23 3.4e-24 3.1e-01 99 PAFAH1B2 ZNF259
12 15 90730363 92135418 1 1 3.0e-09 2.2e-08 1.0e+00 100 FES
13 16 71349498 72845749 4 2 5.7e-10 3.2e-10 1.0e+00 100 DHX38 HPR
14 19 10016470 12191233 6 5 5.8e-18 3.6e-51 1.3e-16 70 C19orf80 EPOR LDLR SLC44A2 SMARCA4
15 19 18740208 20451172 3 1 8.3e-14 9.5e-18 7.2e-06 73 ATP13A1
16 19 44235517 46098885 4 4 2.8e-09 2.8e-62 9.2e-48 24 BCAM PVRL2 TOMM40 ZNF229
17 19 48464978 49935001 2 1 1.5e-07 4.7e-08 9.5e-03 77 NTN5
18 20 62008975 62912463 3 1 1.1e-09 1.8e-08 7.8e-01 100 OPRL1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 9.60 3 3 9.1 0.00 1.0e+00 BCAM TOMM40 ZNF229
Alzheimer’s Disease (in father) 4.08 2 1 3.0 0.00 1.0e+00 TOMM40 ZNF229
Alzheimer’s Disease (including proxy) 18.32 3 3 9.1 0.00 1.0e+00 BCAM TOMM40 ZNF229
Crohns Disease (2017) 2.13 5 0 0.0 0.64 2.4e-01 FES FNDC4 NRBP1 NTN5 USP1
Irritable Bowel Disease (IBD) 1.83 3 0 0.0 0.00 1.0e+00 FES NRBP1 OPRL1
Ulcerative Colitis (UC) 1.54 1 1 3.0 0.00 1.0e+00 OPRL1
Major Depression (MDD) 1.56 1 0 0.0 0.00 1.0e+00 FES
Reaction Time 1.36 1 0 0.0 0.00 1.0e+00 SLC44A2
Breast Cancer 0.95 2 0 0.0 0.00 1.0e+00 FES OPRL1
Ovarian Cancer 1.67 1 0 0.0 0.00 1.0e+00 OPRL1
Coronary Artery Disease (CAD) 7.05 4 2 6.1 -0.93 6.7e-02 EPOR PSRC1 SMARCA4 ZNF259
Crohns Disease (2012) 1.74 2 0 0.0 0.00 1.0e+00 NTN5 USP1
Fasting Glucose 4.91 2 2 6.1 0.00 1.0e+00 FNDC4 NRBP1
HDL Cholesterol 13.01 5 2 6.1 0.44 4.6e-01 APOB LPL PSRC1 TOMM40 ZNF259
LDL Cholesterol 70.57 23 19 57.6 -0.94 1.2e-11 ABCG5 APOB ATP13A1 BCAM C19orf80 COL4A3BP DHX38 EPOR HPR LDLR NTN5 OPRL1 PAFAH1B2 PLEC PSRC1 PVRL2 RP11-288H12.3 SLC44A2 SMARCA4 TOMM40 USP1 ZNF229 ZNF259
Primary Biliary Cirrhosis 1.83 2 0 0.0 0.00 1.0e+00 EPOR NRBP1
Rheumatoid Arthritis 1.33 1 0 0.0 0.00 1.0e+00 OPRL1
Schizophrenia 1.05 1 1 3.0 0.00 1.0e+00 FES
Triglycerides 45.58 9 7 21.2 -0.85 4.0e-03 APOB ATP13A1 FNDC4 HPR LPL PAFAH1B2 RP11-288H12.3 USP1 ZNF259
Ulcerative Colitis 1.54 1 0 0.0 0.00 1.0e+00 PAFAH1B2
Blood Eosinophil Count 1.57 11 4 12.1 0.13 6.9e-01 BCAM EPOR FNDC4 LPL OPRL1 PAFAH1B2 PVRL2 SLC44A2 SMARCA4 TOMM40 ZNF259
Blood Platelet Count 5.09 13 12 36.4 0.04 9.1e-01 ATP13A1 COL4A3BP FNDC4 HPR NRBP1 NTN5 PAFAH1B2 PLEC SLC44A2 SMARCA4 TOMM40 USP1 ZNF259
Blood Red Count 1.05 5 4 12.1 -0.37 5.4e-01 ATP13A1 FES FNDC4 HPR PLEC
Blood White Count 2.38 8 3 9.1 -0.42 3.0e-01 ATP13A1 FES FNDC4 NRBP1 PAFAH1B2 SMARCA4 TMEM133 USP1
Heel T-Score 0.83 4 1 3.0 0.71 2.9e-01 ATP13A1 PSRC1 TMEM133 USP1
BMI 1.70 6 3 9.1 -0.04 9.4e-01 COL4A3BP DHX38 FNDC4 HPR OPRL1 ZNF229
Height 1.88 15 10 30.3 0.67 5.9e-03 ABCG5 ATP13A1 EPOR FES FNDC4 LPL NRBP1 PLEC PSRC1 RP11-288H12.3 SLC44A2 SMARCA4 TMEM133 ZNF229 ZNF259
Waist Hip Ratio (WHR) 1.49 6 1 3.0 -0.40 4.3e-01 ATP13A1 LPL NTN5 OPRL1 PLEC SLC44A2
Systolic Blood Pressure 6.28 10 4 12.1 -0.81 4.3e-03 ABCG5 EPOR FES NRBP1 NTN5 OPRL1 PAFAH1B2 SMARCA4 TMEM133 TOMM40
Smoking Status 1.39 2 0 0.0 0.00 1.0e+00 DHX38 FES
Allergy or Eczema 1.15 2 0 0.0 0.00 1.0e+00 NRBP1 PVRL2
Cardiovascular Disease 13.38 23 19 57.6 -0.93 3.0e-11 ABCG5 APOB BCAM COL4A3BP DHX38 EPOR FES FNDC4 HPR LPL NRBP1 NTN5 OPRL1 PAFAH1B2 PSRC1 PVRL2 RP11-288H12.3 SMARCA4 TMEM133 TOMM40 USP1 ZNF229 ZNF259
Type 2 Diabetes (T2D) 2.80 4 1 3.0 0.69 3.1e-01 ATP13A1 FNDC4 LPL NRBP1
Lung FEV1/FVC ratio 1.10 3 2 6.1 0.00 1.0e+00 NTN5 PSRC1 TMEM133
Lung FVC 0.78 2 1 3.0 0.00 1.0e+00 FNDC4 OPRL1
Chronotype (morning person) 0.99 1 0 0.0 0.00 1.0e+00 SLC44A2
Hair Pigment 0.35 8 3 9.1 -0.48 2.3e-01 DHX38 EPOR FES NRBP1 OPRL1 SLC44A2 SMARCA4 TMEM133
Tanning 0.39 5 1 3.0 0.51 3.8e-01 EPOR FNDC4 NRBP1 PLEC TMEM133
Hand grip strength (left) 1.29 1 0 0.0 0.00 1.0e+00 ABCG5
Number of treatments/medications taken 4.85 7 2 6.1 0.93 2.2e-03 ABCG5 DHX38 FES LDLR NRBP1 PSRC1 TMEM133
Sensitivity / hurt feelings 0.91 1 0 0.0 0.00 1.0e+00 FES
Relative age of first facial hair 1.52 2 0 0.0 0.00 1.0e+00 FNDC4 NRBP1
Systolic blood pressure, automated reading 4.72 3 3 9.1 0.00 1.0e+00 FES OPRL1 TMEM133
Angina 7.45 8 2 6.1 0.96 2.0e-04 ABCG5 C19orf80 FES LPL OPRL1 PSRC1 RP11-288H12.3 TMEM133
Medication: Metformin 2.17 2 0 0.0 0.00 1.0e+00 ABCG5 NRBP1
Diabetes (father) 2.03 1 0 0.0 0.00 1.0e+00 NRBP1
Diabetes (mother) 2.22 2 0 0.0 0.00 1.0e+00 ATP13A1 FNDC4
Impedance of leg (right) 1.75 7 2 6.1 0.51 2.5e-01 ATP13A1 COL4A3BP FES FNDC4 NRBP1 OPRL1 TMEM133
Leg fat-free mass (left) 2.57 8 5 15.2 -0.67 7.2e-02 ATP13A1 COL4A3BP EPOR FNDC4 NRBP1 SLC44A2 SMARCA4 TMEM133
Trunk fat percentage 1.13 4 0 0.0 -0.43 5.7e-01 BCAM COL4A3BP DHX38 HPR
Hand grip strength (right) 1.33 1 1 3.0 0.00 1.0e+00 ABCG5
Average weekly fortified wine intake 1.33 1 0 0.0 0.00 1.0e+00 PLEC
Heel bone mineral density (BMD) T-score, automated (left) 0.90 1 0 0.0 0.00 1.0e+00 TMEM133
High blood pressure 5.19 6 3 9.1 0.95 4.3e-03 ABCG5 DHX38 FES NTN5 OPRL1 TMEM133
Hayfever, allergic rhinitis or eczema 1.17 2 0 0.0 0.00 1.0e+00 NRBP1 PVRL2
Medication: Atenolol 3.89 3 1 3.0 0.00 1.0e+00 FES PSRC1 TMEM133
Sitting height 1.80 8 4 12.1 -0.35 3.9e-01 ATP13A1 FES FNDC4 HPR NRBP1 PLEC SLC44A2 SMARCA4
High blood pressure (mother) 3.39 2 1 3.0 0.00 1.0e+00 FES TMEM133
Body mass index (BMI) 1.36 4 2 6.1 -0.34 6.6e-01 COL4A3BP DHX38 FNDC4 HPR
Impedance of leg (left) 1.78 7 2 6.1 0.51 2.4e-01 ATP13A1 COL4A3BP FES FNDC4 NRBP1 OPRL1 TMEM133
Leg predicted mass (left) 2.56 8 5 15.2 -0.67 7.1e-02 ATP13A1 COL4A3BP EPOR FNDC4 NRBP1 SLC44A2 SMARCA4 TMEM133
Trunk fat mass 1.34 5 1 3.0 -0.17 7.8e-01 BCAM COL4A3BP DHX38 HPR SLC44A2
Waist circumference 1.32 3 1 3.0 0.00 1.0e+00 COL4A3BP DHX38 HPR
Alcohol usually taken with meals 1.04 1 0 0.0 0.00 1.0e+00 FES
Had menopause 1.75 1 1 3.0 0.00 1.0e+00 NRBP1
Forced vital capacity (FVC) 1.39 6 0 0.0 -0.99 2.2e-04 ABCG5 DHX38 EPOR SLC44A2 SMARCA4 TMEM133
Heel bone mineral density (BMD) T-score, automated (right) 0.89 1 0 0.0 0.00 1.0e+00 TMEM133
Qualifications: None of the above 0.78 1 0 0.0 0.00 1.0e+00 USP1
Mouth/teeth dental problems 1.27 1 0 0.0 0.00 1.0e+00 NTN5
Heart attack 5.43 5 2 6.1 0.95 4.0e-03 C19orf80 FES NTN5 PSRC1 RP11-288H12.3
Allergy 1.19 1 0 0.0 0.00 1.0e+00 PVRL2
Diabetes (self-reported) 2.27 2 1 3.0 0.00 1.0e+00 ATP13A1 NRBP1
Medication: Ramipril 3.67 1 1 3.0 0.00 1.0e+00 TMEM133
Medication: Simvastatin 25.35 27 19 57.6 0.99 7.3e-25 ABCG5 APOB ATP13A1 BCAM C19orf80 COL4A3BP DHX38 EPOR FES FNDC4 HPR LDLR LPL NRBP1 NTN5 OPRL1 PAFAH1B2 PLEC PSRC1 PVRL2 SLC44A2 SMARCA4 TMEM133 TOMM40 USP1 ZNF229 ZNF259
Illnesses of siblings 3.24 2 0 0.0 0.00 1.0e+00 FES TMEM133
Weight 2.12 9 4 12.1 -0.40 2.8e-01 ATP13A1 COL4A3BP DHX38 EPOR FNDC4 HPR NRBP1 SLC44A2 SMARCA4
Impedance of arm (right) 1.81 5 2 6.1 0.82 8.9e-02 ATP13A1 COL4A3BP FNDC4 NRBP1 OPRL1
Arm fat percentage (right) 1.40 3 2 6.1 0.00 1.0e+00 COL4A3BP DHX38 HPR
Trunk fat-free mass 3.19 10 8 24.2 -0.67 3.4e-02 ATP13A1 COL4A3BP EPOR FNDC4 NRBP1 PLEC PSRC1 SLC44A2 SMARCA4 TMEM133
Hip circumference 1.79 6 2 6.1 -0.47 3.4e-01 COL4A3BP DHX38 FNDC4 HPR OPRL1 SLC44A2
Alcohol intake versus 10 years previously 2.85 2 1 3.0 0.00 1.0e+00 FNDC4 NRBP1
Father's age at death 2.47 2 1 3.0 0.00 1.0e+00 FES PSRC1
Forced expiratory volume in 1-second (FEV1) 1.54 5 0 0.0 -0.99 9.6e-04 DHX38 EPOR SLC44A2 SMARCA4 TMEM133
Pulse rate 2.01 2 0 0.0 0.00 1.0e+00 FNDC4 NRBP1
Qualifications: A levels/AS levels or equivalent 0.73 1 0 0.0 0.00 1.0e+00 ATP13A1
Serious illness, injury or assault of a close relative in last 2 years 1.62 1 0 0.0 0.00 1.0e+00 NTN5
Mouth/teeth dental problems: Dentures 1.30 2 0 0.0 0.00 1.0e+00 FNDC4 NTN5
Illnesses of mother 3.90 2 1 3.0 0.00 1.0e+00 FES TMEM133
Forced expiratory volume in 1-second (FEV1), Best measure 1.56 5 0 0.0 -1.00 9.8e-05 ABCG5 EPOR SLC44A2 SMARCA4 TMEM133
Impedance of arm (left) 1.92 4 2 6.1 0.87 1.3e-01 COL4A3BP FNDC4 NRBP1 OPRL1
Arm fat mass (right) 1.57 3 2 6.1 0.00 1.0e+00 COL4A3BP DHX38 HPR
Trunk predicted mass 3.17 9 8 24.2 -0.78 1.4e-02 COL4A3BP EPOR FNDC4 NRBP1 PLEC PSRC1 SLC44A2 SMARCA4 TMEM133
Standing height 2.02 11 7 21.2 -0.67 2.5e-02 ABCG5 ATP13A1 EPOR FNDC4 LPL NRBP1 PLEC PSRC1 RP11-288H12.3 SLC44A2 SMARCA4
Hair/balding pattern: Pattern 4 0.62 1 0 0.0 0.00 1.0e+00 FES
Birth weight of first child 2.82 4 1 3.0 -0.42 5.8e-01 ATP13A1 FES OPRL1 SMARCA4
Peak expiratory flow (PEF) 1.32 1 0 0.0 0.00 1.0e+00 NTN5
Blood clot in the leg (DVT) 1.52 1 0 0.0 0.00 1.0e+00 SLC44A2
Headache pain in last month 1.17 1 0 0.0 0.00 1.0e+00 FES
Medication for cholesterol, blood pressure or diabetes 14.35 20 9 27.3 -0.96 5.4e-11 ABCG5 APOB BCAM C19orf80 COL4A3BP DHX38 EPOR FES HPR LDLR NRBP1 NTN5 OPRL1 PAFAH1B2 PSRC1 RP11-288H12.3 SMARCA4 TMEM133 TOMM40 ZNF259
Gout (self-reported) 4.96 2 2 6.1 0.00 1.0e+00 FNDC4 NRBP1
Medication: Amlodipine 2.44 2 2 6.1 0.00 1.0e+00 FES TMEM133
Birth weight 1.58 1 1 3.0 0.00 1.0e+00 FES
Chronic bronchitis/emphysema (mother) 1.45 1 0 0.0 0.00 1.0e+00 BCAM
High blood pressure (siblings) 3.02 2 1 3.0 0.00 1.0e+00 FES TMEM133
Forced vital capacity (FVC), Best measure 1.55 5 1 3.0 -0.99 1.5e-03 ABCG5 EPOR PLEC SLC44A2 SMARCA4
Body fat percentage 1.17 4 1 3.0 -0.47 5.3e-01 BCAM COL4A3BP DHX38 HPR
Leg fat percentage (right) 1.04 4 1 3.0 -0.46 5.4e-01 BCAM COL4A3BP DHX38 HPR
Arm fat-free mass (right) 2.94 8 6 18.2 -0.77 2.4e-02 COL4A3BP EPOR FNDC4 NRBP1 PLEC PSRC1 SLC44A2 SMARCA4
Comparative body size at age 10 0.88 1 0 0.0 0.00 1.0e+00 NTN5
Medication for pain relief, constipation, heartburn 1.21 1 0 0.0 0.00 1.0e+00 NRBP1
Neck or shoulder pain in last month 1.39 1 0 0.0 0.00 1.0e+00 SLC44A2
Medication: Blood pressure 5.11 4 2 6.1 0.92 8.5e-02 ABCG5 FES OPRL1 TMEM133
Angina (self-reported) 7.58 8 2 6.1 0.96 1.6e-04 ABCG5 C19orf80 FES LPL OPRL1 PSRC1 RP11-288H12.3 TMEM133
Medication: Allopurinol 4.13 2 2 6.1 0.00 1.0e+00 FNDC4 NRBP1
Mean time to correctly identify matches 1.53 2 0 0.0 0.00 1.0e+00 FES SLC44A2
Heart disease (mother) 3.67 2 0 0.0 0.00 1.0e+00 ABCG5 FES
Whole body fat mass 1.36 4 1 3.0 -0.32 6.8e-01 BCAM COL4A3BP DHX38 HPR
Leg fat mass (right) 1.37 4 1 3.0 -0.40 6.0e-01 BCAM COL4A3BP DHX38 HPR
Arm predicted mass (right) 2.90 8 5 15.2 -0.77 2.7e-02 COL4A3BP EPOR FNDC4 NRBP1 PLEC PSRC1 SLC44A2 SMARCA4
Pulse rate, automated reading 2.61 4 2 6.1 0.42 5.8e-01 APOB BCAM FNDC4 NRBP1
Alcohol intake frequency. 3.97 3 2 6.1 0.00 1.0e+00 FNDC4 NRBP1 NTN5
Comparative height size at age 10 2.12 7 4 12.1 -0.60 1.5e-01 ATP13A1 FNDC4 NRBP1 NTN5 PLEC PSRC1 SLC44A2
Overall health rating 1.59 2 0 0.0 0.00 1.0e+00 ABCG5 NRBP1
Chest pain or discomfort 1.51 1 0 0.0 0.00 1.0e+00 NTN5
Medication: Aspirin 6.32 5 1 3.0 0.95 1.5e-02 C19orf80 EPOR FES OPRL1 PSRC1
Knee pain experienced in last month 1.35 1 0 0.0 0.00 1.0e+00 SLC44A2
Hypertension (Self-reported) 5.33 6 3 9.1 0.94 4.9e-03 ABCG5 DHX38 FES NTN5 OPRL1 TMEM133
Illnesses of father: Heart disease 8.08 9 2 6.1 0.95 2.0e-05 ABCG5 EPOR FES LPL OPRL1 PSRC1 RP11-288H12.3 SLC44A2 SMARCA4
Forced expiratory volume in 1-second (FEV1), predicted 1.70 3 0 0.0 0.00 1.0e+00 PLEC SLC44A2 SMARCA4
Whole body fat-free mass 2.98 10 7 21.2 -0.65 4.4e-02 ATP13A1 COL4A3BP EPOR FNDC4 NRBP1 PLEC PSRC1 SLC44A2 SMARCA4 TMEM133
Leg fat-free mass (right) 2.59 10 5 15.2 -0.58 8.0e-02 ATP13A1 COL4A3BP EPOR FES FNDC4 NRBP1 PSRC1 SLC44A2 SMARCA4 TMEM133
Arm fat percentage (left) 1.31 3 2 6.1 0.00 1.0e+00 COL4A3BP DHX38 HPR
Diabetes diagnosed by doctor 2.49 3 1 3.0 0.00 1.0e+00 ATP13A1 FNDC4 NRBP1
Ever had stillbirth, spontaneous miscarriage or termination 1.88 1 0 0.0 0.00 1.0e+00 FES
Medication for cholesterol 7.15 11 2 6.1 -0.94 2.1e-05 DHX38 FNDC4 HPR LDLR NRBP1 NTN5 OPRL1 PAFAH1B2 PSRC1 TMEM133 USP1
Back pain experienced in last month 1.54 1 0 0.0 0.00 1.0e+00 APOB
Osteoarthritis (self-reported) 1.51 1 0 0.0 0.00 1.0e+00 SLC44A2
Medication: Aspirin 6.75 5 2 6.1 0.94 1.6e-02 C19orf80 EPOR FES OPRL1 PSRC1
Illnesses of father: None of the above (group 1) 4.09 3 1 3.0 0.00 1.0e+00 ABCG5 FES SLC44A2
Whole body water mass 2.98 10 6 18.2 -0.64 4.5e-02 ATP13A1 COL4A3BP EPOR FNDC4 NRBP1 PLEC PSRC1 SLC44A2 SMARCA4 TMEM133
Leg predicted mass (right) 2.60 10 5 15.2 -0.58 7.8e-02 ATP13A1 COL4A3BP EPOR FES FNDC4 NRBP1 PSRC1 SLC44A2 SMARCA4 TMEM133
Arm fat mass (left) 1.54 4 2 6.1 -0.13 8.7e-01 COL4A3BP DHX38 HPR SLC44A2
Number of self-reported non-cancer illnesses 4.59 7 0 0.0 1.00 9.6e-08 ABCG5 DHX38 FNDC4 NRBP1 NTN5 OPRL1 TMEM133
Medication: Blood pressure 4.24 4 2 6.1 0.91 9.2e-02 DHX38 FES OPRL1 TMEM133
High cholesterol (Self-reported) 50.13 27 26 78.8 0.98 8.5e-21 ABCG5 APOB ATP13A1 BCAM C19orf80 COL4A3BP DHX38 EPOR FNDC4 HPR LDLR LPL NRBP1 NTN5 OPRL1 PAFAH1B2 PLEC PSRC1 PVRL2 RP11-288H12.3 SLC44A2 SMARCA4 TMEM133 TOMM40 USP1 ZNF229 ZNF259
Medication: Bendroflumethiazide 2.17 2 1 3.0 0.00 1.0e+00 FES TMEM133
Medication: Lisinopril 1.84 1 0 0.0 0.00 1.0e+00 TMEM133
Medication: Atorvastatin 21.07 22 11 33.3 0.98 8.3e-16 ABCG5 APOB ATP13A1 BCAM C19orf80 COL4A3BP EPOR FNDC4 HPR LPL NRBP1 PAFAH1B2 PLEC PSRC1 PVRL2 RP11-288H12.3 SLC44A2 SMARCA4 TOMM40 USP1 ZNF229 ZNF259
Illnesses of father: High blood pressure 3.20 3 1 3.0 0.00 1.0e+00 ABCG5 FES TMEM133
Ever smoked 1.27 1 0 0.0 0.00 1.0e+00 FES
Basal metabolic rate 2.76 9 5 15.2 -0.63 6.8e-02 ATP13A1 COL4A3BP EPOR FNDC4 NRBP1 PLEC PSRC1 SLC44A2 SMARCA4
Leg fat percentage (left) 1.02 3 1 3.0 0.00 1.0e+00 BCAM COL4A3BP DHX38
Arm fat-free mass (left) 2.86 8 6 18.2 -0.76 2.8e-02 COL4A3BP EPOR FNDC4 NRBP1 PLEC PSRC1 SLC44A2 SMARCA4
Irritability 1.07 1 0 0.0 0.00 1.0e+00 ATP13A1
Diastolic blood pressure, automated reading 3.79 3 2 6.1 0.00 1.0e+00 C19orf80 FES TMEM133
Vascular/heart problems diagnosed by doctor 6.14 7 3 9.1 -0.96 6.7e-04 ABCG5 DHX38 FES NRBP1 NTN5 OPRL1 TMEM133
Cholesterol lowering medication 23.79 22 16 48.5 0.99 3.6e-17 ABCG5 APOB BCAM C19orf80 COL4A3BP DHX38 EPOR FNDC4 HPR LDLR LPL NRBP1 NTN5 OPRL1 PAFAH1B2 PSRC1 PVRL2 SMARCA4 TOMM40 USP1 ZNF229 ZNF259
Heart attack/myocardial infarction (self-reported) 5.35 4 2 6.1 0.94 1.8e-02 C19orf80 FES PSRC1 RP11-288H12.3
Deep venous thrombosis (DVT) (self-reported) 1.34 1 0 0.0 0.00 1.0e+00 SLC44A2
Heart disease (siblings) 3.68 2 0 0.0 0.00 1.0e+00 FES ZNF259
Impedance of whole body 1.95 5 4 12.1 0.86 5.9e-02 COL4A3BP FNDC4 NRBP1 OPRL1 TMEM133
Leg fat mass (left) 1.37 4 1 3.0 -0.47 5.3e-01 BCAM COL4A3BP DHX38 HPR
Arm predicted mass (left) 2.91 8 7 21.2 -0.78 2.4e-02 COL4A3BP EPOR FNDC4 NRBP1 PLEC PSRC1 SLC44A2 SMARCA4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.53
GTEx Adipose Visceral Omentum 2 0.0982 1.53
GTEx Adrenal Gland 1 0.0686 1.60
GTEx Artery Aorta 4 0.1344 1.59
GTEx Artery Coronary 0 0.0000 1.53
GTEx Artery Tibial 6 0.1595 1.60
GTEx Brain Caudate basal ganglia 0 0.0000 1.35
GTEx Brain Cerebellar Hemisphere 3 0.2015 1.65
GTEx Brain Cerebellum 1 0.0505 1.62
GTEx Brain Cortex 0 0.0000 1.64
GTEx Brain Frontal Cortex BA9 0 0.0000 1.60
GTEx Brain Hippocampus 0 0.0000 1.39
GTEx Brain Hypothalamus 0 0.0000 1.46
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.61
GTEx Brain Putamen basal ganglia 0 0.0000 1.41
GTEx Breast Mammary Tissue 0 0.0000 1.48
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.48
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.51
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.45
GTEx Cells Transformed fibroblasts 8 0.1905 1.61
GTEx Colon Sigmoid 2 0.1368 1.45
GTEx Colon Transverse 0 0.0000 1.50
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.47
GTEx Esophagus Mucosa 9 0.2711 1.65
GTEx Esophagus Muscularis 4 0.1238 1.60
GTEx Heart Atrial Appendage 1 0.0633 1.53
GTEx Heart Left Ventricle 0 0.0000 1.43
GTEx Liver 2 0.2789 1.93
GTEx Lung 1 0.0348 1.53
GTEx Muscle Skeletal 5 0.1730 1.65
GTEx Nerve Tibial 3 0.0694 1.47
GTEx Ovary 1 0.1101 1.60
GTEx Pancreas 2 0.1225 1.53
GTEx Pituitary 2 0.1794 1.55
GTEx Prostate 1 0.1198 1.61
GTEx Skin Not Sun Exposed Suprapubic 4 0.1627 1.51
GTEx Skin Sun Exposed Lower leg 5 0.1374 1.60
GTEx Small Intestine Terminal Ileum 0 0.0000 1.61
GTEx Spleen 3 0.2126 1.50
GTEx Stomach 2 0.1376 1.58
GTEx Testis 3 0.0951 1.52
GTEx Thyroid 5 0.1250 1.56
GTEx Uterus 0 0.0000 1.41
GTEx Vagina 2 0.3150 1.67
GTEx Whole Blood 5 0.2509 1.71
METSIM Adipose 3 0.0651 1.46
NTR Blood 4 0.1665 1.59
ROSMAP Brain Pre-frontal Cortex 7 0.1594 1.63
YFS Blood 6 0.1299 1.56
CommonMind Brain Pre-frontal Cortex 7 0.1302 1.59
TCGA Breast Tumor 0 0.0000 1.34
TCGA Breast Normal 3 0.0713 1.43
TCGA Ovarian Tumor 3 0.1027 1.51
TCGA Prostate Tumor 4 0.1156 1.45