TWAS hub - TLR4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0720	0.0240	2.6e-04	0.016	0.033	0.023	0.035	0.025	4.6e-03	6.2e-05	8.0e-04	3.9e-05	4.8e-04
2	GTEx	Esophagus Muscularis	0.1330	0.0510	4.2e-03	0.016	NA	-0.003	NA	0.005	3.7e-02	NA	5.0e-01	NA	1.4e-01
3	GTEx	Spleen	0.2460	0.0920	5.0e-03	0.122	NA	0.119	NA	0.086	4.9e-04	NA	5.9e-04	NA	3.2e-03
4	GTEx	Whole Blood	0.1310	0.0420	4.4e-04	0.135	NA	0.104	NA	0.127	1.9e-12	NA	7.9e-10	NA	9.8e-12
5	NTR	Blood	0.0669	0.0149	7.8e-16	0.088	0.059	0.086	0.086	0.087	8.5e-27	1.8e-18	1.9e-26	2.5e-26	1.1e-26
6	YFS	Blood	0.5506	0.0400	0.0e+00	0.227	0.354	0.358	0.386	0.350	7.1e-73	3.9e-122	7.6e-124	9.2e-136	2.0e-120

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Mood swings	10.2	18.5	33.3	-3.1	-1.2	-3.8	-4.9	-5.8	-5.3
Neuroticism (Nagel 2018)	10.1	23.8	44.5	-2.8	-0.8	-4.3	-5.8	-6.7	-6.1
Depressed Affect (Nagel 2018)	9.8	20.6	38.3	-2.5	-0.8	-4.4	-5.2	-6.2	-5.6
Neuroticism	9.2	22.3	40.6	-3.0	-0.6	-4.0	-5.7	-6.4	-6.0
Neuroticism score	8.3	17.3	30.9	-2.6	-0.3	-4.1	-4.9	-5.6	-5.1
Neuroticism (2016)	8.0	11.5	18.3	-3.3	-2.3	-3.3	-3.7	-4.3	-3.2
Fed-up feelings	7.4	13.5	26.8	-1.2	-1.1	-3.8	-4.8	-5.2	-3.9
Number of operations (self-reported)	7.1	10.5	20.3	-1.1	-0.0	-4.5	-3.7	-3.9	-3.6
Had other major operations	5.4	6.6	12.6	0.2	-0.9	-2.5	-3.6	-3.5	-2.8
Headache pain in last month	5.3	9.1	17.6	-0.7	-0.8	-2.7	-3.7	-4.2	-3.8
Major Depression (MDD)	5.2	6.4	10.2	-2.4	-1.6	-0.8	-3.2	-3.0	-3.2
Miserableness	5.2	9.0	16.5	-1.0	0.7	-3.2	-3.3	-3.8	-4.1
Loneliness, isolation	5.0	6.9	15.1	0.4	-0.2	-2.9	-3.4	-3.9	-2.6
Worrier / anxious feelings	4.9	9.3	16.3	-2.0	-1.3	-3.4	-3.3	-4.0	-3.5
Age at First Birth	4.8	7.0	13.2	2.2	0.6	2.2	2.5	3.6	3.4
Ever unenthusiastic/disinterested for a whole week	4.8	5.9	9.4	-1.8	0.8	-2.8	-2.7	-3.1	-2.7
Irritability	4.7	8.0	15.9	-2.2	-0.5	-1.0	-3.8	-4.0	-3.4
Worry (Nagel 2018)	4.5	9.6	15.1	-2.5	0.2	-3.3	-3.1	-3.9	-3.9
Friendships satisfaction	4.5	5.5	10.6	-0.7	-0.9	-2.0	-3.3	-3.1	-2.8
Nervous feelings	4.4	8.1	12.5	-1.8	0.7	-3.5	-2.8	-3.5	-3.5
Pack years adult smoking proportion	4.3	6.6	13.0	0.0	-2.3	-1.4	-3.4	-3.6	-2.9
Depression (Nagel 2018)	4.2	6.4	13.0	-1.5	1.4	-2.3	-2.6	-3.0	-3.6
Alzheimer’s Disease (including proxy)	4.0	5.7	8.2	-2.7	-1.0	-1.8	-2.8	-2.6	-2.9
Alzheimer’s Disease (in mother)	3.9	4.6	6.3	-2.5	-0.8	-1.8	-2.5	-2.3	-2.4
Commuting to job workplace: Car/motor vehicle	3.9	4.5	9.0	-0.9	-1.3	-0.2	-2.7	-2.9	-3.0
Pack years of smoking	3.7	5.4	10.3	0.2	-2.4	-1.0	-3.0	-3.2	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	3.5	4.6	8.0	-0.7	0.5	-2.6	-2.4	-2.8	-2.6
Alcohol intake frequency.	3.5	8.1	15.9	-1.3	0.1	-2.0	-3.7	-3.6	-4.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.5	4.1	7.8	-2.8	2.8	-2.7	-0.3	-0.3	-1.2
Frequency of depressed mood in last 2 weeks	3.3	4.7	8.8	-0.2	0.4	-1.7	-3.0	-2.9	-2.8
Qualifications: nursing, teaching	3.3	5.1	10.0	-0.1	2.0	1.6	2.9	3.2	2.3
Pain type(s) experienced in last month: Hip pain	3.3	4.1	5.7	-1.8	-1.4	-2.1	-2.0	-2.3	-2.4
Stomach or abdominal pain in last month	3.1	3.9	10.4	-3.2	0.5	-0.9	-2.3	-2.3	-1.2
Hearing difficulty/problems with background noise	3.1	5.0	9.2	-0.1	-0.8	-2.4	-2.7	-2.6	-3.0
Seen doctor (GP) for nerves, anxiety, tension or depression	3.1	4.7	7.1	-2.4	0.5	-2.0	-2.7	-2.5	-2.1
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.4	8.6	-0.2	-0.2	-2.9	-2.3	-2.6	-2.4
Alzheimer’s Disease (in father)	2.7	3.0	5.2	-1.3	0.1	-1.6	-2.3	-2.2	-1.9
Taking other prescription medications	2.6	4.0	8.4	-0.4	-1.7	0.0	-2.7	-2.3	-2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	5.6	-1.5	0.7	-1.9	-2.4	-2.4	-1.7
Emphysema/chronic bronchitis	2.6	2.9	5.6	0.7	1.8	1.4	2.4	2.2	1.1
Illnesses of siblings: Diabetes	2.6	3.3	7.8	-0.2	-0.0	-1.2	-2.4	-2.8	-2.1
Number of self-reported non-cancer illnesses	2.6	4.5	8.4	-0.5	-1.3	-1.9	-2.4	-2.7	-2.9
Depression (self-reported)	2.4	2.8	5.6	-1.7	-1.7	1.0	-2.1	-2.4	-0.7
Age at first live birth	2.4	4.2	10.2	0.8	1.6	0.8	3.0	3.2	1.5
Mean time to correctly identify matches	2.4	4.6	9.8	2.1	-1.3	3.1	1.6	1.9	2.3
Guilty feelings	2.4	3.6	6.2	-0.5	0.6	-2.2	-2.2	-2.5	-2.2
Age started oral contraceptive pill	2.4	2.9	6.6	0.8	-0.1	1.2	1.9	2.3	2.6
HbA1C	2.3	2.5	4.7	0.7	2.0	0.9	2.2	2.0	1.1
Number of treatments/medications taken	2.3	4.1	12.0	-0.5	-0.8	-0.8	-2.4	-2.4	-3.5
Sensitivity / hurt feelings	2.3	4.0	6.6	-1.7	-1.5	-0.7	-2.5	-2.6	-2.3
Suffer from ‘nerves’	2.3	3.6	6.3	-0.9	0.6	-1.6	-2.5	-2.5	-2.4
Happiness	2.2	2.7	5.7	-0.7	-0.8	-0.4	-2.3	-2.4	-2.0
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	11.4	0.5	3.4	0.4	1.3	1.6	0.8
Falls in the last year	2.1	2.9	6.4	-0.4	-0.9	-0.8	-2.0	-2.3	-2.5
Pulse rate	2.1	3.6	6.3	-0.4	-1.0	-1.5	-2.5	-2.5	-2.4
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	5.1	-2.3	-0.7	-1.7	-1.2	-1.6	-1.3
Medication for pain relief, constipation, heartburn	2.1	3.5	9.1	-0.4	0.9	2.1	1.7	1.9	3.0
Heart disease (mother)	2.1	2.6	4.2	0.7	-1.9	0.2	-1.9	-2.1	-2.0
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	5.2	0.5	1.0	1.8	2.1	2.3	1.2
Commuting to job workplace: Cycle	2.1	2.5	4.9	-0.3	1.2	0.5	2.1	2.2	2.0
BMI	2.0	11.6	23.3	2.0	-2.0	3.2	-4.8	-4.8	-2.2
Ever had hysterectomy (womb removed)	2.0	2.2	4.5	-1.4	-0.2	-2.1	-1.3	-1.9	-1.2
Pain experienced in last month	2.0	3.4	6.5	0.4	-1.4	1.4	1.9	2.5	2.6
Hearing difficulty/problems: Yes	1.8	2.7	6.7	0.3	0.1	-2.0	-1.5	-1.8	-2.6
Ever highly irritable/argumentative for 2 days	1.8	2.1	3.7	-1.6	-0.8	-0.9	-1.5	-1.7	-1.9
Medication: Paracetamol	1.8	3.0	5.1	-0.4	-0.9	-1.5	-2.2	-2.2	-2.3
Worry too long after embarrassment	1.8	3.0	6.7	-0.6	0.6	-0.9	-2.4	-2.6	-1.9
Age at last live birth	1.8	2.6	5.7	0.3	1.0	1.4	2.4	2.1	1.6
Family relationship satisfaction	1.8	2.2	4.8	-0.5	-0.3	-0.6	-2.2	-2.1	-1.8
Body Mass Index (BMI) (2010)	1.7	2.3	6.2	1.2	-0.3	2.5	-1.7	-1.8	-0.3
Leg pain on walking	1.7	2.1	5.8	-2.4	-0.2	-0.8	-1.6	-1.6	-1.1
Ever taken oral contraceptive pill	1.7	1.9	5.5	-0.9	2.4	-2.2	0.1	-0.2	-0.3
Cardiovascular Disease	1.6	5.2	11.3	-0.7	-0.8	0.6	-3.3	-3.4	-2.7
Supplements: Glucosamine	1.6	2.1	5.2	-1.9	1.4	1.1	-0.7	-0.2	-2.3
Arm fat percentage (right)	1.6	6.3	18.7	2.4	-1.8	4.3	-2.4	-2.2	0.2
Qualifications: College or University degree	1.6	5.0	8.2	-0.2	-0.9	2.6	2.5	2.9	2.8
Medication: Gliclazide	1.6	1.8	8.0	-1.1	-0.9	-2.8	-0.5	-0.5	-0.6
Illnesses of siblings	1.5	2.1	7.0	1.1	0.4	1.1	1.0	1.4	2.6
Arm fat mass (right)	1.5	6.0	10.3	1.7	-1.6	3.2	-3.2	-3.1	-0.7
Number of children fathered	1.5	1.7	5.4	1.3	-0.9	2.3	0.6	0.7	1.1
Whole body fat mass	1.5	6.2	11.0	1.8	-2.2	2.6	-3.3	-3.3	-0.7
Overall health rating	1.5	3.2	7.0	0.5	-2.3	0.1	-2.7	-2.2	-1.2
Arm fat mass (left)	1.5	6.2	10.7	1.8	-1.7	3.1	-3.3	-3.1	-0.7
Financial situation satisfaction	1.5	1.9	5.9	-1.1	0.1	-0.3	-1.5	-2.4	-1.3
High blood pressure (mother)	1.4	1.9	3.7	-0.1	0.9	-1.4	-1.4	-1.9	-1.8
Body mass index (BMI)	1.4	5.8	10.2	1.5	-1.9	3.2	-3.0	-2.9	-0.9
Medication: Ramipril	1.4	1.8	7.5	1.3	0.4	-2.7	-0.1	-0.2	-1.2
Tense / ‘highly strung’	1.4	2.3	5.5	0.3	1.0	-1.6	-1.1	-1.8	-2.3
Number of full brothers	1.4	1.8	3.1	-1.1	-1.2	1.8	-1.1	-1.7	-1.1
Arm fat percentage (left)	1.4	5.6	16.2	1.8	-1.7	4.0	-2.4	-2.3	-0.0
Medication: Paracetamol	1.4	2.2	4.1	-0.4	-0.4	-1.3	-2.0	-1.9	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	5.4	0.4	1.1	-0.5	-1.2	-1.3	-2.3
Type 2 Diabetes (T2D) (2018)	1.3	2.5	4.8	-1.1	-0.7	-1.4	-1.7	-2.2	-2.0
Trunk fat percentage	1.3	5.0	7.5	2.2	-2.5	2.7	-2.5	-2.3	0.2
Townsend deprivation index at recruitment	1.3	1.8	3.3	1.7	-1.7	1.8	-0.5	0.0	1.2
Trunk fat mass	1.3	5.4	8.3	2.2	-2.0	2.6	-2.9	-2.9	-0.3
Pulse wave Arterial Stiffness index	1.3	1.5	6.5	0.6	-1.2	2.5	-0.3	-0.3	0.5
Hair/balding pattern: Pattern 4	1.3	3.2	7.7	0.9	-1.6	-2.8	-1.1	-1.8	-1.8
Gout (self-reported)	1.3	1.7	2.9	1.7	-1.1	0.2	1.0	1.6	1.6
Body fat percentage	1.3	5.3	9.9	2.3	-2.4	3.1	-2.4	-2.3	0.0
Pulse wave peak to peak time	1.3	1.5	6.5	-0.5	1.4	-2.5	0.4	0.5	-0.3
Number of full sisters	1.3	1.6	4.0	0.8	1.1	0.2	2.0	1.9	0.6
Medication: Aspirin	1.3	1.7	4.2	-0.0	-2.0	-1.9	-0.9	-1.0	-1.0
Leg fat mass (left)	1.3	5.2	9.8	2.0	-1.5	2.1	-3.1	-3.1	-1.0
Bipolar Disorder (2011)	1.2	1.1	2.0	1.4	-1.3	-1.0	0.8	0.8	1.0
Systolic blood pressure, automated reading	1.2	3.4	6.1	1.1	-2.5	2.3	1.4	1.3	2.0
Medication: Co-codamol	1.2	1.3	4.1	-0.6	0.8	-0.3	-1.1	-1.2	-2.0
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	2.9	-0.3	0.4	-1.0	-1.4	-1.7	-1.3
Mouth/teeth dental problems	1.2	1.8	7.5	1.7	-2.7	-0.2	-0.4	-0.4	-0.2
Alcohol intake versus 10 years previously	1.2	1.8	4.2	1.4	0.1	-0.5	-1.9	-2.0	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	4.2	0.2	-0.6	-0.8	-1.7	-2.1	-1.9
Hair/balding pattern: Pattern 3	1.2	1.8	4.8	0.7	0.1	2.2	0.8	1.5	1.7
Illnesses of mother	1.2	1.5	3.8	0.6	0.6	1.3	0.9	1.3	1.9
Chest pain or discomfort	1.2	1.7	2.4	-1.1	-0.3	-1.3	-1.6	-1.6	-1.5
Back pain experienced in last month	1.2	1.8	3.5	-1.2	0.3	1.0	-1.5	-1.7	-1.9
Commuting to job workplace: Public transport	1.2	1.5	5.2	0.9	0.0	0.6	1.1	1.1	2.3
Medication: Lisinopril	1.2	1.5	6.1	0.2	1.7	2.5	-0.1	-0.4	-0.3
Leg fat percentage (left)	1.2	4.4	5.9	2.3	-1.9	2.4	-2.4	-2.3	-0.6
Basal cell carcinoma (self-reported)	1.2	1.4	4.5	2.1	0.3	-1.2	0.9	1.0	0.7
Reaction Time	1.1	2.1	6.3	1.5	-0.7	2.5	0.8	1.1	1.4
Peak expiratory flow (PEF)	1.1	2.6	5.8	-0.2	1.0	-2.2	-1.2	-1.6	-2.4
Pulse wave reflection index	1.1	1.3	2.6	0.0	0.4	1.4	1.6	1.3	1.2
Neck or shoulder pain in last month	1.1	1.5	5.8	-1.1	0.9	-2.4	-0.6	-0.7	-0.7
Medication: Ibuprofen	1.1	1.4	3.7	-0.2	-0.2	-0.7	-1.4	-1.4	-1.9
Medication: Omeprazole	1.1	1.4	4.4	0.0	0.9	-0.7	-1.0	-1.2	-2.1
Handedness (chirality/laterality): Left-handed	1.1	1.3	5.7	2.4	0.2	-1.0	0.4	0.9	0.1
Commuting to job workplace: Walk	1.1	1.2	3.4	0.9	0.5	-0.1	1.9	1.6	0.6
Diastolic blood pressure, automated reading	1.1	3.4	10.3	1.6	-3.2	1.4	-1.6	-1.7	0.1
Primary Biliary Cirrhosis	1.0	1.4	2.9	-0.2	1.7	-1.1	1.6	1.2	0.5
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.9	1.3	-0.8	-2.0	-0.6	-0.4	-0.8
Medication: Atenolol	1.0	1.3	2.6	0.7	-1.2	1.6	1.1	1.4	-0.1
Medication: Levothyroxine sodium	1.0	1.7	3.0	-0.9	-1.3	1.6	-1.7	-1.4	-0.6
Financial difficulties in last 2 years	1.0	1.3	2.8	-0.0	0.4	-0.0	-1.6	-1.6	-1.7
Allergy	1.0	2.3	5.1	0.4	-1.8	1.1	1.3	1.6	2.3
Asthma	1.0	1.9	4.4	0.5	0.8	-0.5	-1.8	-2.1	-1.7
Chronic bronchitis/emphysema (mother)	1.0	1.2	1.5	-1.2	-0.7	-1.1	-1.1	-1.2	-1.1
High blood pressure (siblings)	1.0	1.4	3.6	-1.6	0.2	-1.5	0.2	-0.0	-1.9
Wheeze or whistling in the chest in last year	1.0	1.8	7.5	-0.6	2.7	-0.3	-0.2	-1.1	-1.1
Leg fat mass (right)	1.0	4.0	7.2	1.9	-1.3	2.1	-2.6	-2.7	-0.6
Average weekly red wine intake	1.0	1.5	2.8	0.0	-1.4	-0.4	1.6	1.2	1.7
Waist Hip Ratio (WHR)	0.9	3.8	9.5	3.1	-0.1	-0.1	2.3	2.3	1.6
Current tobacco smoking	0.9	1.5	3.0	-1.3	-0.2	0.3	-1.5	-1.7	-1.4
Qualifications: CSEs or equivalent	0.9	1.2	2.2	0.9	-0.1	-1.5	-1.4	-1.4	-0.6
Hayfever, allergic rhinitis or eczema	0.9	2.0	5.0	-0.4	1.2	-1.7	-1.1	-1.1	-2.2
Qualifications: None of the above	0.9	2.0	3.6	-1.0	-0.9	-1.0	-1.5	-1.9	-1.9
Weight	0.9	4.5	9.6	1.6	-1.0	2.0	-3.0	-3.1	-0.7
Hip circumference	0.9	3.9	7.2	1.3	-1.2	2.4	-2.7	-2.7	-0.5
Leg fat percentage (right)	0.9	3.2	5.4	2.1	-1.7	2.3	-1.8	-1.8	-0.2
Health satisfaction	0.9	1.2	3.1	-1.8	0.3	1.6	-0.7	-0.8	-0.6
Smoking status: Previous	0.9	1.3	3.2	1.0	1.4	-1.8	0.8	0.7	0.7
Medication: Aspirin	0.9	1.1	3.5	0.5	-1.9	-1.3	-0.7	-0.7	-0.6
Average weekly champagne plus white wine intake	0.9	1.3	4.1	-2.0	-1.2	1.1	0.5	0.6	0.6
Wears glasses or contact lenses	0.9	1.1	3.9	-0.4	-2.0	0.4	-0.6	-0.1	-1.3
Mother’s age at death	0.9	1.1	2.1	-1.2	-1.0	0.4	-1.4	-1.4	-0.6
Crohns Disease (2017)	0.8	1.7	3.0	-1.5	1.7	0.0	1.6	1.5	0.5
Irritable Bowel Disease (IBD)	0.8	2.0	2.8	-1.7	1.6	1.1	1.6	1.6	0.6
HDL Cholesterol	0.8	1.4	2.2	-1.4	-1.4	-1.5	-1.0	-0.8	-0.6
Smoking Status	0.8	2.0	4.6	-0.5	-0.2	-1.2	-1.9	-2.1	-1.3
Chronotype (morning person)	0.8	1.9	6.9	-0.9	1.0	-2.6	1.1	0.9	-1.0
Severe depression (siblings)	0.8	0.9	1.9	1.4	-1.0	0.5	0.6	0.4	1.2
Maternal smoking around birth	0.8	1.2	3.4	0.3	0.2	-0.4	-1.8	-1.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.4	-0.8	0.1	1.8	1.2	1.5	1.6
Medication: Lansoprazole	0.8	0.9	1.9	-0.1	-1.0	1.2	0.6	1.0	1.4
Birth weight of first child	0.8	1.5	2.8	-1.3	0.0	-1.7	-1.1	-1.4	-1.1
Glaucoma (self-reported)	0.8	0.9	4.0	2.0	-0.5	0.8	0.3	0.6	0.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.8	-0.6	-1.9	0.6	-1.7	-1.2	-0.3
Medication: Blood pressure	0.8	1.4	3.4	1.0	-1.8	-0.9	-0.8	-1.0	-1.3
Supplements: Vitamin C	0.8	0.9	2.6	-0.9	0.6	-1.6	-0.6	-0.9	-0.8
Diabetes diagnosed by doctor	0.8	1.3	2.1	-0.9	-0.7	-1.2	-1.0	-1.4	-1.4
Mineral and other dietary supplements	0.8	1.1	3.2	0.4	-1.8	-1.1	-0.6	-0.8	0.9
Heart attack/myocardial infarction (self-reported)	0.8	1.0	5.1	0.1	-2.3	-0.5	0.6	0.3	0.1
Respiratory disease	0.7	1.5	3.7	0.9	1.9	0.1	-0.9	-1.2	-1.4
Average weekly fortified wine intake	0.7	0.8	1.4	0.2	-1.2	0.7	0.9	0.8	1.1
High blood pressure	0.7	2.1	5.6	0.6	-2.4	-1.2	-1.2	-1.5	-1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	3.5	-0.5	1.0	-1.9	0.3	0.6	0.0
Waist circumference	0.7	2.7	5.9	2.3	-1.2	2.4	-1.3	-1.3	-0.0
Pain all over the body in last month	0.7	0.7	1.5	-0.5	0.4	-0.6	-1.0	-1.1	-1.2
Mouth/teeth dental problems: Dentures	0.7	1.2	2.8	-1.7	-0.0	-0.2	-1.1	-1.2	-1.3
Loud music exposure frequency	0.7	0.8	3.4	1.9	0.5	-0.1	-0.7	-0.4	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.2	0.2	-0.7	-0.9	-1.1	-0.6	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.3	1.1	0.4	-1.0	1.0	1.1	1.0
Ever had bowel cancer screening	0.7	0.8	1.8	-0.1	-0.8	-0.6	-1.1	-0.8	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	5.2	-2.3	0.6	0.2	-0.7	-0.8	-0.4
Breast cancer (self-reported)	0.7	0.8	1.5	-0.3	-1.2	0.6	-1.0	-1.1	-0.9
Asthma (self-reported)	0.7	1.4	2.9	0.3	1.2	-0.2	-1.3	-1.7	-1.4
Smoking status: Current	0.7	1.1	1.8	-1.2	-0.0	0.9	-1.1	-1.3	-1.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.2	1.0	0.7	1.1	0.8	0.9	0.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.8	1.3	0.8	0.6	1.1	1.1	-0.2
Illnesses of father: High blood pressure	0.7	0.8	4.4	0.5	0.4	-2.1	-0.2	0.1	0.3
Arm fat-free mass (left)	0.7	3.3	9.0	1.1	0.1	0.3	-2.8	-3.0	-1.3
Ever depressed for a whole week	0.7	0.8	2.3	-0.8	1.5	-0.5	-0.5	-1.1	-0.4
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.2	-0.1	1.8	1.3	1.1	1.5	1.5
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	2.6	0.4	0.5	-0.3	1.6	1.3	0.6
Heart disease (siblings)	0.7	0.9	2.9	-1.7	0.7	-0.9	0.3	0.1	-1.1
Arm predicted mass (left)	0.7	3.4	9.1	1.2	-0.1	0.4	-2.8	-3.0	-1.4
Ovarian Cancer	0.6	0.9	4.8	2.2	-0.5	-0.2	0.1	-0.2	-0.0
Crohns Disease (2012)	0.6	0.9	1.7	-0.7	0.3	-0.5	1.3	1.3	1.2
Fasting Glucose	0.6	0.7	1.4	-0.8	0.1	1.2	1.0	0.7	0.8
Rheumatoid Arthritis	0.6	0.8	2.0	0.7	1.4	-0.7	0.6	1.2	0.1
Schizophrenia (2014)	0.6	1.3	2.4	0.6	-0.5	-1.4	1.5	1.4	1.1
Ulcerative Colitis	0.6	0.9	3.0	-0.8	-0.1	1.7	0.5	0.6	0.9
Hypothyroidism (self reported)	0.6	1.4	3.2	0.6	-0.8	1.0	-1.8	-1.7	-0.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.8	1.0	0.2	-0.2	0.8	0.5	1.3
Diabetes (mother)	0.6	0.8	1.3	1.1	-0.3	0.7	-1.1	-1.1	-0.6
Impedance of leg (right)	0.6	2.9	11.0	0.1	1.1	-3.3	1.7	1.6	0.0
Serious illness, injury or assault to yourself	0.6	0.7	3.1	0.6	-0.5	-1.8	-0.1	0.1	0.8
Heart attack	0.6	0.8	4.1	-0.0	-2.0	-0.8	0.2	-0.1	-0.3
Impedance of arm (right)	0.6	2.7	6.0	1.2	-0.0	0.2	1.9	2.4	2.3
Prospective memory result	0.6	0.7	1.5	1.2	0.6	-1.2	0.4	0.9	-0.0
Medication: Amlodipine	0.6	0.8	1.9	1.4	-1.0	0.0	1.0	0.7	0.8
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.1	0.1	0.6	0.4	-1.0	-1.1	-1.4
Arm fat-free mass (right)	0.6	3.1	8.6	0.7	0.3	-0.5	-2.5	-2.9	-1.6
Comparative body size at age 10	0.6	1.6	3.5	-0.8	-0.5	0.9	-1.9	-1.8	-1.0
Eye problems/disorders: None of the above	0.6	0.7	1.4	-0.7	-1.2	0.2	-1.2	-1.0	0.2
Arm predicted mass (right)	0.6	3.0	8.5	0.7	0.4	-0.4	-2.5	-2.9	-1.6
Leg fat-free mass (right)	0.6	3.0	7.8	1.1	-0.4	1.3	-2.6	-2.8	-0.5
Osteoporosis (self-reported)	0.6	0.7	3.6	-0.1	-1.9	0.3	-0.1	0.4	-0.6
Medication: Atorvastatin	0.6	0.7	1.6	0.4	-1.1	-1.3	0.8	0.5	0.6
Fractured/broken bones in last 5 years	0.6	0.8	2.1	1.3	1.4	-0.4	0.4	0.6	-0.0
Schizophrenia (2018)	0.5	1.0	1.7	0.7	-0.7	-1.3	1.0	1.0	1.1
Schizophrenia vs Biploar Disorder	0.5	0.6	2.5	0.7	-1.6	-0.7	-0.0	0.3	-0.2
Average weekly spirits intake	0.5	0.6	2.4	-0.7	1.5	-0.9	0.1	-0.3	0.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.0	-0.6	-0.6	0.1	-1.4	-0.9	-0.5
Supplements: Zinc	0.5	0.6	1.7	0.8	1.3	0.8	0.5	0.3	0.1
Multivitamins +/- minerals	0.5	0.7	1.6	-0.7	-0.3	1.3	-0.5	-0.8	-1.0
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	-1.2	-1.3	0.0	-0.6	-0.4	-0.5
Impedance of leg (left)	0.5	2.3	10.8	0.4	0.7	-3.3	1.0	1.0	-0.4
Diabetes (self-reported)	0.5	0.8	1.8	-0.7	-0.6	-0.5	-0.8	-1.3	-1.0
Medication: Simvastatin	0.5	0.7	1.7	-0.5	1.2	0.3	-0.6	-0.6	-1.3
Number of live births	0.5	0.7	2.8	-1.0	-0.3	-1.7	0.4	-0.2	0.2
Noisy workplace	0.5	0.6	1.6	1.3	-0.3	-1.1	0.8	0.6	0.0
Exposure to tobacco smoke at home	0.5	0.6	1.1	0.8	-1.0	-0.7	-0.4	-0.7	-0.8
Blood clot in the leg (DVT)	0.5	0.6	1.9	0.6	0.4	-0.3	1.4	1.0	0.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.0	-1.0	1.4	0.5	0.4	0.6	1.3
Medication: Seretide 50 evohaler	0.5	0.6	2.2	-0.5	1.5	0.2	0.1	0.1	-1.0
Had major operations	0.5	0.6	2.7	0.0	0.4	-1.7	-0.4	-0.9	-0.0
Knee pain experienced in last month	0.5	0.8	3.6	0.5	1.9	0.6	0.4	0.2	0.2
Hypertension (Self-reported)	0.5	1.4	3.0	0.3	-1.7	-1.2	-1.1	-1.3	-1.1
Leg predicted mass (right)	0.5	2.9	7.4	1.2	-0.4	1.3	-2.6	-2.7	-0.4
Basal metabolic rate	0.5	2.8	7.3	1.2	0.0	1.0	-2.5	-2.7	-0.8
Unable to work because of sickness or disability	0.5	0.6	1.7	-0.4	-0.6	-0.1	-1.3	-0.9	-0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	2.3	0.6	-0.5	-1.5	1.4	1.0	0.4
Ulcerative Colitis (UC)	0.4	0.8	1.2	-1.0	0.8	1.1	0.9	1.0	0.4
Coronary Artery Disease (CAD)	0.4	0.5	1.8	-0.7	1.4	0.6	-0.5	0.0	0.1
Mean Putamen Volume	0.4	0.5	1.4	-1.2	0.8	-0.1	-0.4	-0.8	-0.2
Lupus	0.4	0.6	2.2	-0.7	-0.0	0.5	0.7	0.1	1.5
Systolic Blood Pressure	0.4	2.0	4.3	-0.5	-0.7	1.3	2.1	1.4	1.9
Allergy or Eczema	0.4	1.0	1.9	0.9	1.3	-1.1	0.5	0.5	-1.4
Vitamin and mineral supplements	0.4	0.6	2.3	-0.2	-0.1	-0.3	0.7	0.9	1.5
Leg fat-free mass (left)	0.4	2.3	5.7	1.1	-0.3	1.4	-2.2	-2.4	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	4.0	0.5	2.0	-0.2	-0.4	-0.2	-0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.7	1.3	-0.5	0.4	0.2	0.3	0.8
Leg predicted mass (left)	0.4	2.4	6.1	1.1	-0.3	1.3	-2.3	-2.5	-0.2
Past tobacco smoking	0.4	0.7	2.3	-0.3	-1.5	1.3	-0.4	-0.3	-0.3
Alcohol usually taken with meals	0.4	0.7	1.2	-0.6	-0.5	1.1	0.8	1.0	0.9
Hair/balding pattern: Pattern 2	0.4	0.6	1.2	-0.7	0.3	0.0	-0.9	-0.8	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.5	0.7	1.6	-0.5	-0.8	-0.8	-1.0
Trunk fat-free mass	0.4	2.0	5.0	1.0	1.1	0.0	-1.9	-2.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.4	-0.2	-0.4	-0.5	-0.6	-0.9	-1.2
Impedance of arm (left)	0.4	1.9	4.7	0.2	-0.2	-0.5	1.7	2.2	1.9
Trunk predicted mass	0.4	2.0	4.9	1.0	1.1	0.1	-1.9	-2.2	-1.2
Length of working week for main job	0.4	0.4	1.5	-1.2	0.7	0.4	0.5	-0.0	0.0
Birth weight	0.4	0.8	2.5	0.9	1.1	-1.6	0.4	0.0	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.2	0.5	-1.1	-0.7	0.8	0.6	0.1
Pulse rate, automated reading	0.4	1.3	2.9	1.7	-1.6	-0.5	-1.1	-0.9	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.7	-0.9	0.4	-0.3	-0.8	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	4.0	0.2	0.7	-2.0	-0.6	-0.6	0.5
Whole body fat-free mass	0.4	2.3	6.3	1.1	0.3	0.7	-2.2	-2.5	-0.9
Long-standing illness, disability or infirmity	0.4	0.7	1.2	1.1	0.4	0.2	-1.0	-0.7	-1.0
Eye problems/disorders: Cataract	0.4	0.5	1.5	0.1	1.2	-0.9	0.5	0.4	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	0.7	-1.0	0.5	0.7	0.8	0.4
Whole body water mass	0.4	2.4	6.8	1.0	0.4	0.5	-2.3	-2.6	-1.0
Eye problems/disorders: Glaucoma	0.4	0.5	2.2	1.5	0.1	0.3	0.4	0.8	-0.1
Ever smoked	0.4	0.7	1.3	0.4	1.1	-0.8	0.8	0.5	1.0
Average weekly beer plus cider intake	0.4	0.6	1.8	1.0	0.1	-1.4	0.4	0.8	-0.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.0	0.3	0.8	1.0	-0.4	-0.3	-1.0
Myopia	0.4	0.6	2.7	0.3	-1.6	0.7	0.5	0.4	0.3
Impedance of whole body	0.4	1.9	3.8	0.6	0.1	-1.9	1.6	2.0	1.0
Bipolar Disorder (2018)	0.3	0.4	1.0	0.0	-0.0	-0.9	1.0	0.3	-0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.8	-0.7	0.4	0.8	-0.0	0.6	0.9
Height	0.3	6.2	22.4	2.0	-0.4	-4.7	-1.9	-2.0	-1.7
Lung FEV1/FVC ratio	0.3	1.4	7.0	0.3	-0.5	2.6	-0.8	-0.7	-0.4
Lung FVC	0.3	1.8	4.7	-1.2	0.8	0.0	2.2	1.6	1.2
Medication for hormone replacement therapy	0.3	0.3	0.8	0.6	0.9	-0.4	-0.5	-0.6	-0.0
Medication: Metformin	0.3	0.4	0.9	0.5	-0.7	-0.9	-0.4	-0.6	-0.5
Fluid intelligence score	0.3	0.7	3.0	-0.9	1.7	0.1	0.4	0.6	-0.1
Lung cancer (father)	0.3	0.3	0.6	-0.8	0.7	0.8	0.1	-0.3	-0.3
Forced vital capacity (FVC), Best measure	0.3	1.1	2.7	-1.3	1.7	-0.8	0.7	0.5	0.9
Shortness of breath walking on level ground	0.3	0.3	0.7	-0.8	-0.2	0.7	-0.5	-0.7	-0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.4	-1.2	0.4	-0.7	0.0	-0.4	-0.3
Migraine (self-reported)	0.3	0.3	1.5	1.2	-0.1	0.0	0.2	0.2	0.6
Medication for cholesterol	0.3	0.4	1.1	0.4	-1.0	0.5	0.2	0.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.0	-1.1	-0.7	1.4	0.1	0.2	0.6
Risk taking	0.3	0.5	1.8	-0.6	0.6	0.4	-0.1	-0.6	-1.4
Supplements: Calcium	0.3	0.3	0.5	-0.6	-0.0	0.7	0.3	0.6	-0.6
Alcohol drinker status: Previous	0.3	0.4	1.1	0.2	-0.2	0.4	-1.0	-0.6	-0.7
Blood Eosinophil Count	0.2	1.8	3.2	1.7	-1.8	-1.5	-0.8	-0.7	-1.0
Blood Red Count	0.2	1.6	3.8	1.0	-1.9	1.5	-0.7	-0.5	1.4
Relative age of first facial hair	0.2	0.3	1.2	-0.3	-1.1	0.3	0.0	0.2	0.6
Age when periods started (menarche)	0.2	0.5	0.8	0.9	-0.9	-0.7	-0.2	-0.4	-0.7
Number of incorrect matches in round	0.2	0.3	1.0	0.7	-0.1	1.0	-0.0	-0.4	-0.6
Had menopause	0.2	0.3	0.8	-0.6	-0.9	-0.3	-0.5	0.0	-0.6
Time employed in main current job	0.2	0.2	0.5	-0.5	-0.0	0.4	-0.5	-0.1	-0.7
Medication: Cholesterol lowering	0.2	0.4	1.2	0.4	-0.8	-0.2	-0.4	-0.4	-1.1
Standing height	0.2	1.9	6.4	0.8	1.5	-2.5	-0.8	-1.2	-0.1
Exposure to tobacco smoke outside home	0.2	0.2	1.3	-0.1	-0.1	-1.1	0.2	0.2	-0.3
Medication: Allopurinol	0.2	0.3	1.2	0.5	-1.1	-0.1	0.0	0.3	0.2
Illnesses of father: Heart disease	0.2	0.3	0.8	-0.9	0.7	-0.5	-0.5	-0.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.5	0.7	0.6	0.2	-0.5	-0.7	-0.2
Medication: Blood pressure	0.2	0.4	0.9	-0.9	1.0	0.1	0.5	0.4	-0.4
High cholesterol (Self-reported)	0.2	0.4	1.5	-0.1	0.7	0.2	-0.5	-0.3	-1.2
Alcohol drinker status: Never	0.2	0.3	0.8	-0.8	0.0	-0.9	-0.2	-0.1	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.2	1.1	1.1	-0.1	0.1	-0.1	0.4	-0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	0.2	-0.8	0.6	-0.7	-0.3	-0.5
Breast Cancer	0.1	0.4	0.9	-0.2	0.8	-0.0	0.7	0.9	0.2
LDL Cholesterol	0.1	0.2	0.3	0.3	-0.5	-0.4	0.5	0.5	0.1
Triglycerides	0.1	0.2	0.9	0.1	0.3	0.2	0.9	0.5	-0.0
Blood Platelet Count	0.1	0.6	1.4	1.1	-0.3	1.2	0.4	-0.7	-0.5
Blood White Count	0.1	0.7	2.5	0.1	-1.6	-0.3	-0.3	-1.0	0.5
Heel T-Score	0.1	1.1	3.1	-1.8	1.6	-0.6	-0.1	0.6	0.1
Tanning	0.1	1.0	1.8	-1.2	1.2	-1.3	0.2	-0.5	-1.1
Hand grip strength (left)	0.1	0.4	1.0	-1.0	-0.3	-0.8	0.1	-0.3	-0.7
Angina	0.1	0.1	0.5	0.7	-0.4	0.3	0.1	0.0	-0.1
Diabetes (father)	0.1	0.1	0.3	0.4	0.0	0.6	-0.1	-0.4	0.5
Hand grip strength (right)	0.1	0.3	1.4	-1.2	-0.5	-0.2	0.4	-0.1	-0.3
Relative age voice broke	0.1	0.2	0.4	0.4	-0.6	0.6	0.1	0.2	0.4
Sitting height	0.1	0.6	1.7	-0.6	0.2	-1.3	-0.7	-0.9	0.6
Forced vital capacity (FVC)	0.1	0.5	1.3	-1.1	0.9	-0.8	0.3	0.3	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.1	0.4	0.5	0.3	0.2	0.1
Father’s age at death	0.1	0.2	0.6	-0.2	-0.2	0.1	0.7	0.8	0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.7	-0.5	0.8	-0.5	-0.3	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.4	-0.8	1.2	-0.4	0.2	0.0	0.5
Breastfed as a baby	0.1	0.1	0.2	-0.3	0.4	0.0	0.5	0.3	0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.5	0.5	0.2	-0.1	-0.1	-0.2
Angina (self-reported)	0.1	0.1	0.5	0.4	-0.7	0.2	-0.0	-0.2	-0.2
Comparative height size at age 10	0.1	0.6	2.6	1.6	-0.3	-0.6	-0.6	-0.2	0.6
Osteoarthritis (self-reported)	0.1	0.2	0.5	-0.4	0.7	0.3	-0.6	-0.1	0.0
Hearing aid user	0.1	0.2	0.5	-0.7	0.3	-0.5	-0.0	-0.2	-0.5
Medication: Bendroflumethiazide	0.1	0.1	0.4	0.2	0.2	0.6	-0.0	-0.3	0.2
Cholesterol lowering medication	0.1	0.2	0.6	-0.8	0.2	-0.3	-0.3	-0.2	-0.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.6	2.9	1.7	-0.5	0.2	-0.5	-0.1	0.1

Hub : Genes

TLR4

Models

Trait associations