TWAS hub - JAG1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0157	0.0078	0.0140	0.00	0.00	-0.001	0	0.000	3.8e-01	0.4800	0.7900	0.27	0.48000
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0800	0.0390	0.0031	0.08	0.03	0.047	NA	0.055	2.5e-05	0.0077	0.0011	NA	0.00042

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Heel bone mineral density (BMD) T-score, automated (right)	10.5	24.2	35.1	-3.6	-5.9
Heel bone mineral density (BMD) T-score, automated (left)	10.1	22.9	26.8	-4.4	-5.2
Heel T-Score	9.2	73.5	81.0	-8.1	-9.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	7.2	15.3	27.0	-5.2	-1.9
Diastolic blood pressure, automated reading	6.2	19.4	38.7	-6.2	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	6.0	19.3	38.6	-6.2	-0.1
Forced expiratory volume in 1-second (FEV1)	5.6	19.0	36.5	-6.0	-1.2
Hand grip strength (left)	5.4	14.3	27.8	-5.3	1.0
Forced vital capacity (FVC)	5.2	20.2	35.7	-6.0	-2.2
Hand grip strength (right)	4.9	13.3	25.7	-5.1	1.0
Forced vital capacity (FVC), Best measure	4.9	17.8	34.7	-5.9	-1.0
Osteoporosis (self-reported)	4.6	5.6	7.9	1.8	2.8
Medication: Ventolin 100micrograms inhaler	4.1	5.3	7.2	2.7	-1.9
Frequency of tiredness / lethargy in last 2 weeks	3.9	6.4	9.4	-3.1	-1.9
Neuroticism (2016)	3.7	5.3	9.9	-3.1	-0.9
Medication: Seretide 50 evohaler	3.5	4.0	6.6	2.6	-1.2
Lung FVC	3.4	17.4	26.2	-5.1	-2.9
Average weekly red wine intake	3.3	4.8	9.0	-3.0	-0.8
Neuroticism	3.2	7.7	14.3	-3.8	-1.1
Diverticular disease/diverticulitis (self-reported)	3.2	3.9	4.9	2.2	-1.7
Hair/balding pattern: Pattern 4	3.2	7.8	15.6	-4.0	-0.2
Peak expiratory flow (PEF)	3.0	7.1	13.2	-3.6	-0.9
Commuting to job workplace: Cycle	2.9	3.5	6.7	-2.6	0.6
Ever used hormone-replacement therapy (HRT)	2.8	3.6	6.5	2.6	-0.8
Heart disease (siblings)	2.8	3.4	3.6	-1.9	-1.8
Birth weight	2.7	5.9	11.8	-3.4	0.0
Mouth/teeth dental problems: Loose teeth	2.7	3.2	5.0	1.1	2.2
Myopia	2.7	3.9	5.6	1.5	2.4
Taking other prescription medications	2.6	4.1	5.8	1.5	-2.4
Miserableness	2.6	4.6	7.1	-2.7	-1.5
Mouth/teeth dental problems: Dentures	2.5	4.2	8.2	0.4	-2.9
Mood swings	2.5	4.5	9.0	-3.0	-0.2
Pain experienced in last month	2.5	4.2	7.8	2.8	0.8
Allergy or Eczema	2.4	6.3	12.6	-3.6	0.3
Hayfever, allergic rhinitis or eczema	2.4	5.1	9.6	-3.1	-0.8
Had menopause	2.4	3.0	5.7	-0.5	-2.4
Illnesses of father: High blood pressure	2.4	3.0	5.9	-2.4	0.3
Angina (self-reported)	2.3	3.0	3.0	1.7	-1.7
Asthma	2.2	4.3	4.5	2.1	-2.0
Illnesses of father: Heart disease	2.2	3.0	5.8	-2.4	-0.5
Angina	2.1	2.7	2.8	1.7	-1.6
Neuroticism score	2.1	4.5	7.5	-2.7	-1.2
Type 2 Diabetes (T2D) (2012)	2.0	2.3	4.4	0.3	2.1
Sitting height	2.0	14.1	28.2	-5.3	0.0
Medication: Simvastatin	2.0	2.9	4.9	-0.9	-2.2
Worry too long after embarrassment	2.0	3.3	6.1	-2.5	-0.7
Coronary Artery Disease (CAD)	1.9	2.3	3.1	-1.2	-1.8
Lupus	1.9	2.9	5.3	2.3	-0.7
Ever had bowel cancer screening	1.9	2.2	4.4	0.0	-2.1
Asthma (self-reported)	1.9	3.8	4.4	2.1	-1.8
Prostate Cancer	1.8	2.6	3.6	1.9	1.2
Length of working week for main job	1.8	1.9	3.8	0.2	2.0
Medication: Atorvastatin	1.8	2.2	4.3	0.3	-2.1
Risk taking	1.8	2.6	5.1	2.3	0.4
Basal cell carcinoma (self-reported)	1.8	2.2	3.9	-0.6	-2.0
Neuroticism (Nagel 2018)	1.7	4.1	6.8	-2.6	-1.1
Prospective memory result	1.7	2.2	2.4	1.6	-1.4
Comparative height size at age 10	1.7	9.1	15.7	-4.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	6.3	-2.5	0.9
Commuting to job workplace: Walk	1.7	1.9	3.4	-1.9	-0.6
Breast cancer (self-reported)	1.7	2.0	3.9	-2.0	-0.4
Depression (Nagel 2018)	1.6	2.5	3.8	-1.9	-1.1
HbA1C	1.6	1.8	2.3	1.1	1.5
Number of treatments/medications taken	1.6	2.9	3.7	1.9	-1.4
Pulse wave peak to peak time	1.6	1.9	2.3	-1.5	1.2
Illnesses of siblings: Diabetes	1.6	2.0	3.8	0.4	-2.0
Depressed Affect (Nagel 2018)	1.5	3.1	4.1	-2.0	-1.4
Fasting Glucose	1.5	1.7	2.6	1.6	-0.9
Maternal smoking around birth	1.5	2.2	4.4	2.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.3	-1.8	-0.8
Medication: Levothyroxine sodium	1.5	2.6	4.3	2.1	-1.0
Standing height	1.5	15.1	27.5	-5.2	-1.6
Birth weight of first child	1.5	2.8	5.1	-2.3	-0.7
Headache pain in last month	1.5	2.5	5.0	-2.2	0.0
Emphysema/chronic bronchitis	1.5	1.7	3.3	1.8	-0.2
Hypothyroidism (self reported)	1.4	3.1	3.3	1.8	-1.7
Respiratory disease	1.4	3.2	3.7	1.9	-1.7
Fed-up feelings	1.4	2.5	3.1	-1.8	-1.4
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	3.7	-1.9	-0.1
Trunk fat-free mass	1.4	8.0	15.1	-3.9	-1.0
Worrier / anxious feelings	1.4	2.7	5.5	-2.3	-0.0
Happiness	1.4	1.7	2.2	-1.5	1.1
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	2.7	1.6	-1.6
Leg fat percentage (right)	1.4	5.2	5.3	2.2	-2.3
Pack years of smoking	1.4	2.0	2.9	1.0	-1.7
Sensitivity / hurt feelings	1.3	2.2	4.1	-2.0	-0.5
Trunk predicted mass	1.3	7.7	14.5	-3.8	-0.9
Neck or shoulder pain in last month	1.3	1.9	2.8	-1.7	1.0
Had major operations	1.3	1.5	2.9	0.2	1.7
Family relationship satisfaction	1.3	1.6	2.8	0.6	1.7
Medication: Gliclazide	1.3	1.4	2.8	0.3	-1.7
Illnesses of father: None of the above (group 1)	1.3	1.6	2.4	1.6	0.9
Supplements: Calcium	1.3	1.4	2.7	1.6	0.3
Qualifications: CSEs or equivalent	1.2	1.6	1.8	-1.4	-1.2
Alcohol usually taken with meals	1.2	1.9	2.0	1.4	1.4
Father’s age at death	1.2	1.6	3.2	1.8	0.1
Medication: Cholesterol lowering	1.2	1.8	3.4	0.5	-1.9
Pulse wave Arterial Stiffness index	1.2	1.5	1.6	1.2	-1.3
Body fat percentage	1.2	4.7	6.8	1.6	-2.6
Shortness of breath walking on level ground	1.2	1.4	1.9	1.0	-1.4
Suffer from ‘nerves’	1.2	1.9	2.9	-1.0	-1.7
Loneliness, isolation	1.2	1.6	1.8	-1.4	-1.2
Friendships satisfaction	1.2	1.4	2.9	-0.1	1.7
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	2.5	-1.6	-1.1
Supplements: Fish oil (including cod liver oil)	1.2	1.6	1.8	1.2	-1.3
Arm fat-free mass (left)	1.2	5.9	10.3	-3.2	-1.3
Arm predicted mass (left)	1.2	6.3	11.4	-3.4	-1.1
Worry (Nagel 2018)	1.1	2.4	4.6	-2.1	0.4
Waist Hip Ratio (WHR)	1.1	4.8	8.4	1.1	-2.9
Chronotype (morning person)	1.1	2.4	2.9	1.4	-1.7
Trunk fat percentage	1.1	4.3	7.4	1.2	-2.7
Stomach or abdominal pain in last month	1.1	1.4	1.8	-1.3	1.0
Mouth/teeth dental problems	1.1	1.8	2.8	0.8	1.7
Falls in the last year	1.1	1.4	2.5	0.6	1.6
Whole body fat-free mass	1.1	6.5	11.6	-3.4	-1.1
Whole body water mass	1.1	6.4	11.8	-3.4	-1.0
High cholesterol (Self-reported)	1.1	1.9	3.6	0.4	-1.9
Leg fat percentage (left)	1.1	4.0	4.3	2.1	-1.9
Mean Putamen Volume	1.0	1.2	2.1	-1.4	0.5
Height	1.0	19.7	37.0	-6.1	-1.6
Hearing difficulty/problems with background noise	1.0	1.6	2.5	-0.8	-1.6
Allergy	1.0	2.3	3.4	1.1	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.2	-1.5	0.1
Migraine (self-reported)	1.0	1.2	1.4	-1.2	-1.0
Basal metabolic rate	1.0	5.4	9.2	-3.0	-1.3
Irritability	1.0	1.7	3.0	-1.7	-0.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.2	-1.5	-0.3
Blood White Count	0.9	6.7	8.2	2.9	-2.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	1.9	-1.4	0.6
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.2	-1.1	-0.9
Trunk fat mass	0.9	4.1	8.1	0.2	-2.8
Waist circumference	0.9	3.4	6.1	0.9	-2.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.9	0.5	1.4
Medication: Lansoprazole	0.9	1.0	1.5	0.7	-1.2
Lung cancer (father)	0.9	1.1	2.0	1.4	0.4
Arm fat-free mass (right)	0.9	4.6	8.5	-2.9	-0.9
Heart disease (mother)	0.9	1.1	2.1	-0.0	-1.5
Whole body fat mass	0.9	3.6	7.1	0.3	-2.7
Arm predicted mass (right)	0.9	4.7	8.0	-2.8	-1.2
Arm fat percentage (left)	0.9	3.6	4.1	1.8	-2.0
Medication: Aspirin	0.9	1.1	2.0	-0.5	-1.4
Smoking status: Current	0.9	1.5	2.1	1.4	-0.9
Average weekly champagne plus white wine intake	0.9	1.3	2.5	-0.4	1.6
Guilty feelings	0.9	1.4	1.9	-0.9	-1.4
Schizophrenia vs Biploar Disorder	0.8	1.1	2.1	-0.3	-1.4
Cardiovascular Disease	0.8	2.6	4.9	-2.2	-0.5
Average weekly spirits intake	0.8	1.0	1.8	1.4	-0.4
Had other major operations	0.8	0.9	1.2	-1.1	-0.8
Weight	0.8	3.9	4.4	-1.8	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.7	-0.3	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.9	-0.0	1.4
Leg fat mass (right)	0.8	3.0	4.7	1.2	-2.2
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.6	1.3	0.5
Medication: Aspirin	0.8	1.0	1.9	-0.5	-1.4
Knee pain experienced in last month	0.8	1.3	2.6	-1.6	0.0
Leg fat-free mass (right)	0.8	4.5	8.1	-2.9	-0.9
Leg predicted mass (right)	0.8	4.4	8.0	-2.8	-0.9
Financial situation satisfaction	0.8	1.0	2.0	0.1	1.4
HDL Cholesterol	0.7	1.2	2.4	-1.5	0.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.5	-1.2	-0.7
Hearing difficulty/problems: Yes	0.7	1.0	1.8	1.4	0.5
Medication for hormone replacement therapy	0.7	0.7	1.3	1.2	-0.3
Pack years adult smoking proportion	0.7	1.0	1.0	1.0	-1.0
Leg fat-free mass (left)	0.7	3.7	5.4	-2.3	-1.4
Leg predicted mass (left)	0.7	3.6	5.3	-2.3	-1.3
Hair/balding pattern: Pattern 2	0.7	0.9	1.8	-0.1	-1.3
Illnesses of siblings	0.7	1.0	1.7	1.3	0.6
Arm fat percentage (right)	0.7	2.7	3.3	1.5	-1.8
High blood pressure (siblings)	0.7	1.1	1.9	-0.4	1.4
Comparative body size at age 10	0.7	2.0	2.6	1.6	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.6	0.5	1.3
Supplements: Vitamin C	0.7	0.9	1.5	0.6	1.2
Age started oral contraceptive pill	0.7	0.8	1.5	1.2	0.4
Leg fat mass (left)	0.7	2.6	4.1	1.1	-2.0
Systolic blood pressure, automated reading	0.6	1.8	3.2	1.8	0.7
Current tobacco smoking	0.6	0.9	1.4	1.2	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.6	-1.3	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.0	-1.0	0.7
Pulse wave reflection index	0.6	0.8	0.9	-0.8	-1.0
Age at first live birth	0.6	1.0	2.0	-1.4	0.1
Number of full sisters	0.6	0.7	1.5	-0.1	1.2
Fractured/broken bones in last 5 years	0.6	0.7	1.4	1.2	-0.2
Cholesterol lowering medication	0.6	0.8	1.5	-0.4	-1.2
Bipolar Disorder (2018)	0.5	0.8	1.5	0.2	-1.2
Bipolar Disorder or Schizophrenia	0.5	1.1	2.2	0.2	-1.5
Alzheimer’s Disease (in father)	0.5	0.6	0.8	0.9	-0.6
Ovarian Cancer	0.5	0.7	1.3	-0.2	1.1
Blood Eosinophil Count	0.5	4.1	6.0	2.4	-1.5
Number of incorrect matches in round	0.5	0.8	1.6	1.3	-0.0
Depression (self-reported)	0.5	0.6	0.9	-0.6	1.0
Tense / ‘highly strung’	0.5	0.8	1.6	-1.3	0.0
Blood clot in the leg (DVT)	0.5	0.6	1.1	-1.1	0.3
Health satisfaction	0.5	0.6	1.3	-1.1	-0.1
Medication: Ibuprofen	0.5	0.6	0.7	-0.8	0.8
Mother’s age at death	0.5	0.6	0.7	-0.8	0.8
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.3	-0.2	-1.2
Medication: Lisinopril	0.5	0.7	1.1	0.6	-1.0
Alcohol drinker status: Never	0.5	0.6	1.1	-0.3	-1.1
Average weekly beer plus cider intake	0.5	0.7	1.2	1.1	-0.4
Intelligence (Savage-Jansen 2018)	0.4	1.4	1.6	-1.2	1.1
Alzheimer’s Disease (in mother)	0.4	0.4	0.9	-0.9	-0.1
Ulcerative Colitis	0.4	0.6	0.8	0.6	0.9
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	0.3	-0.9
Supplements: Zinc	0.4	0.4	0.8	0.9	-0.3
Medication: Co-codamol	0.4	0.5	0.7	-0.8	0.5
Diabetes (father)	0.4	0.5	1.1	0.2	1.0
Diabetes (self-reported)	0.4	0.6	0.9	0.9	-0.6
Fluid intelligence score	0.4	0.9	1.5	0.5	1.2
Time employed in main current job	0.4	0.5	0.6	0.8	-0.5
Alcohol intake versus 10 years previously	0.4	0.6	1.1	1.1	-0.2
Number of live births	0.4	0.5	0.7	-0.6	-0.8
Arm fat mass (right)	0.4	1.5	3.1	0.1	-1.8
Medication: Amlodipine	0.4	0.6	0.7	0.6	0.9
Wheeze or whistling in the chest in last year	0.4	0.7	1.3	1.1	-0.4
Number of children fathered	0.4	0.5	1.0	1.0	-0.0
Age at last live birth	0.4	0.6	1.1	-1.0	0.4
Smoking status: Previous	0.4	0.7	0.7	-0.8	0.8
Medication for cholesterol	0.4	0.5	0.8	-0.9	0.5
Arm fat mass (left)	0.4	1.8	3.7	0.2	-1.9
Number of self-reported non-cancer illnesses	0.4	0.7	1.2	0.5	-1.1
Wears glasses or contact lenses	0.4	0.5	0.9	-1.0	-0.2
Ever taken oral contraceptive pill	0.4	0.5	0.5	-0.7	0.7
Commuting to job workplace: Public transport	0.4	0.5	1.0	-1.0	0.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.1	-1.1	0.1
Breast Cancer	0.3	0.8	1.1	0.7	-1.0
Rheumatoid Arthritis	0.3	0.4	0.8	-0.3	0.9
Smoking Status	0.3	0.7	0.8	0.7	-0.9
Vitamin and mineral supplements	0.3	0.4	0.7	-0.8	-0.1
Diabetes (mother)	0.3	0.4	0.6	0.8	-0.4
Impedance of leg (right)	0.3	1.3	1.9	1.4	-0.9
Townsend deprivation index at recruitment	0.3	0.4	0.6	-0.5	0.8
Average weekly fortified wine intake	0.3	0.3	0.6	0.1	0.8
Body mass index (BMI)	0.3	1.3	2.5	0.4	-1.6
Nervous feelings	0.3	0.5	0.6	-0.8	-0.6
Impedance of arm (left)	0.3	1.4	1.4	1.2	-1.1
Breastfed as a baby	0.3	0.3	0.6	0.8	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.0	-0.1	-1.0
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.5	-0.4	0.7
Gout (self-reported)	0.3	0.4	0.5	-0.7	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	0.1	0.8
Diabetes diagnosed by doctor	0.3	0.5	0.9	1.0	-0.4
Eye problems/disorders: Cataract	0.3	0.4	0.8	0.0	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.6	0.8	-0.0
Mineral and other dietary supplements	0.3	0.4	0.5	-0.5	0.7
Osteoarthritis (self-reported)	0.3	0.4	0.7	-0.3	0.8
Schizophrenia (2018)	0.2	0.4	0.8	0.2	-0.9
Ulcerative Colitis (UC)	0.2	0.3	0.5	0.4	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.8	0.4	0.9
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	-0.2	0.8
Crohns Disease (2012)	0.2	0.4	0.6	0.3	0.8
Schizophrenia (2014)	0.2	0.5	0.8	0.4	-0.9
Triglycerides	0.2	0.4	0.6	0.4	-0.7
Blood Red Count	0.2	1.8	3.2	-1.8	-0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.5	-0.4	0.7
Hair Pigment	0.2	5.7	9.3	3.0	-1.5
Severe depression (siblings)	0.2	0.2	0.3	-0.6	-0.3
Relative age voice broke	0.2	0.3	0.6	-0.0	0.8
High blood pressure	0.2	0.5	0.9	-1.0	0.3
Supplements: Glucosamine	0.2	0.2	0.4	-0.7	0.1
Medication: Atenolol	0.2	0.2	0.5	-0.7	0.0
Heart attack	0.2	0.3	0.6	-0.0	-0.7
Pain all over the body in last month	0.2	0.2	0.4	0.6	-0.1
Medication: Ramipril	0.2	0.2	0.3	-0.5	-0.4
Impedance of arm (right)	0.2	1.0	1.1	0.9	-1.0
Hip circumference	0.2	0.7	1.1	-0.6	-1.0
Hair/balding pattern: Pattern 3	0.2	0.4	0.5	-0.5	0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.7	0.8	-0.4
Exposure to tobacco smoke at home	0.2	0.3	0.4	-0.4	0.6
Exposure to tobacco smoke outside home	0.2	0.3	0.6	0.7	0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	0.3	0.8
Mean time to correctly identify matches	0.2	0.4	0.7	0.8	0.4
Pulse rate, automated reading	0.2	0.5	0.6	0.8	0.7
Alcohol intake frequency.	0.2	0.5	0.6	0.8	-0.7
Long-standing illness, disability or infirmity	0.2	0.3	0.6	0.8	-0.0
Qualifications: nursing, teaching	0.2	0.2	0.2	-0.5	-0.5
Medication: Blood pressure	0.2	0.4	0.5	-0.5	0.7
Medication: Bendroflumethiazide	0.2	0.2	0.3	0.6	-0.4
Ever depressed for a whole week	0.2	0.2	0.4	0.3	0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.7	-0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	0.1	-0.6
Impedance of whole body	0.2	0.8	1.0	1.0	-0.7
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.1	-0.4
Crohns Disease (2017)	0.1	0.1	0.2	-0.1	0.5
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.3	0.6
Major Depression (MDD)	0.1	0.1	0.2	-0.1	-0.5
Reaction Time	0.1	0.3	0.4	0.6	0.4
LDL Cholesterol	0.1	0.1	0.2	0.5	-0.1
Primary Biliary Cirrhosis	0.1	0.1	0.1	-0.3	0.3
Blood Platelet Count	0.1	0.9	1.7	-1.3	0.4
BMI	0.1	0.5	0.8	0.4	-0.9
Systolic Blood Pressure	0.1	0.6	0.6	0.8	0.8
Lung FEV1/FVC ratio	0.1	0.6	1.1	-0.5	1.0
Relative age of first facial hair	0.1	0.1	0.2	0.5	-0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.2	0.4
Multivitamins +/- minerals	0.1	0.1	0.2	0.4	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	-0.4	0.2
High blood pressure (mother)	0.1	0.2	0.4	-0.1	0.6
Impedance of leg (left)	0.1	0.5	0.9	1.0	-0.2
Past tobacco smoking	0.1	0.1	0.1	0.4	0.2
Qualifications: None of the above	0.1	0.3	0.5	0.7	-0.4
Financial difficulties in last 2 years	0.1	0.2	0.4	0.1	0.6
Pulse rate	0.1	0.1	0.2	0.4	-0.2
Illnesses of mother	0.1	0.1	0.1	-0.3	-0.3
Loud music exposure frequency	0.1	0.1	0.2	0.4	-0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.2	-0.5
Medication: Paracetamol	0.1	0.1	0.2	-0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.1	0.6
Glaucoma (self-reported)	0.1	0.1	0.1	-0.2	0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.5	-0.3
Qualifications: College or University degree	0.1	0.3	0.3	-0.6	0.6
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.3	0.4
Medication: Blood pressure	0.1	0.1	0.1	0.2	-0.4
Medication: Allopurinol	0.1	0.1	0.2	0.5	0.3
Leg pain on walking	0.1	0.1	0.1	-0.1	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	0.3	0.1
Hypertension (Self-reported)	0.1	0.3	0.6	-0.8	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.5	-0.1
Back pain experienced in last month	0.1	0.1	0.1	-0.3	0.3
Hearing aid user	0.1	0.1	0.2	0.4	0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	-0.3	0.2
Ever smoked	0.1	0.2	0.3	-0.6	-0.1
Unable to work because of sickness or disability	0.1	0.2	0.3	-0.2	-0.5
Alcohol drinker status: Previous	0.1	0.1	0.2	0.0	0.4
Age at First Birth	0.0	0.0	0.1	0.1	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	-0.1	-0.1
Tanning	0.0	0.0	0.0	-0.0	0.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.1	0.1	-0.1	0.3
Medication: Metformin	0.0	0.0	0.0	-0.1	-0.2
Age when periods started (menarche)	0.0	0.0	0.1	-0.1	-0.3
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.1	0.1	-0.3
Noisy workplace	0.0	0.0	0.0	-0.1	0.2
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	-0.1	0.2
Number of full brothers	0.0	0.0	0.1	0.2	0.0
Medication: Omeprazole	0.0	0.0	0.0	-0.1	-0.2
Overall health rating	0.0	0.0	0.1	-0.2	0.1
Chest pain or discomfort	0.0	0.1	0.1	0.3	-0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	-0.0	0.3
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	-0.2	0.2
Medication: Paracetamol	0.0	0.0	0.0	0.1	0.1
Number of operations (self-reported)	0.0	0.1	0.1	-0.2	-0.3
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	0.5	0.1

Hub : Genes

JAG1

Models

Trait associations