Hub : Genes

JAG1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.0157 0.0078 0.0140 0.00 0.00 -0.001 0 0.000 3.8e-01 0.4800 0.7900 0.27 0.48000
2 TCGA Kidney Renal Papillary Cell Carcinoma 0.0800 0.0390 0.0031 0.08 0.03 0.047 NA 0.055 2.5e-05 0.0077 0.0011 NA 0.00042

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.5 0.8 1.5 0.2 -1.2
Bipolar Disorder or Schizophrenia 0.5 1.1 2.2 0.2 -1.5
Depressed Affect (Nagel 2018) 1.5 3.1 4.1 -2.0 -1.4
Depression (Nagel 2018) 1.6 2.5 3.8 -1.9 -1.1
Intelligence (Savage-Jansen 2018) 0.4 1.4 1.6 -1.2 1.1
Neuroticism (Nagel 2018) 1.7 4.1 6.8 -2.6 -1.1
Schizophrenia (2018) 0.2 0.4 0.8 0.2 -0.9
Schizophrenia vs Biploar Disorder 0.8 1.1 2.1 -0.3 -1.4
Worry (Nagel 2018) 1.1 2.4 4.6 -2.1 0.4
Alzheimer’s Disease (in mother) 0.4 0.4 0.9 -0.9 -0.1
Alzheimer’s Disease (in father) 0.5 0.6 0.8 0.9 -0.6
Alzheimer’s Disease (including proxy) 0.1 0.1 0.2 -0.1 -0.4
Crohns Disease (2017) 0.1 0.1 0.2 -0.1 0.5
Irritable Bowel Disease (IBD) 0.1 0.2 0.4 0.3 0.6
Ulcerative Colitis (UC) 0.2 0.3 0.5 0.4 0.7
Major Depression (MDD) 0.1 0.1 0.2 -0.1 -0.5
Reaction Time 0.1 0.3 0.4 0.6 0.4
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.8 0.4 0.9
Breast Cancer 0.3 0.8 1.1 0.7 -1.0
Ovarian Cancer 0.5 0.7 1.3 -0.2 1.1
Prostate Cancer 1.8 2.6 3.6 1.9 1.2
Age at First Birth 0.0 0.0 0.1 0.1 0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 -0.1 -0.1
Body Mass Index (BMI) (2010) 0.2 0.3 0.6 -0.2 0.8
Coronary Artery Disease (CAD) 1.9 2.3 3.1 -1.2 -1.8
Crohns Disease (2012) 0.2 0.4 0.6 0.3 0.8
Mean Putamen Volume 1.0 1.2 2.1 -1.4 0.5
Fasting Glucose 1.5 1.7 2.6 1.6 -0.9
HbA1C 1.6 1.8 2.3 1.1 1.5
HDL Cholesterol 0.7 1.2 2.4 -1.5 0.3
LDL Cholesterol 0.1 0.1 0.2 0.5 -0.1
Lupus 1.9 2.9 5.3 2.3 -0.7
Neuroticism (2016) 3.7 5.3 9.9 -3.1 -0.9
Primary Biliary Cirrhosis 0.1 0.1 0.1 -0.3 0.3
Rheumatoid Arthritis 0.3 0.4 0.8 -0.3 0.9
Schizophrenia (2014) 0.2 0.5 0.8 0.4 -0.9
Triglycerides 0.2 0.4 0.6 0.4 -0.7
Type 2 Diabetes (T2D) (2012) 2.0 2.3 4.4 0.3 2.1
Ulcerative Colitis 0.4 0.6 0.8 0.6 0.9
Blood Eosinophil Count 0.5 4.1 6.0 2.4 -1.5
Blood Platelet Count 0.1 0.9 1.7 -1.3 0.4
Blood Red Count 0.2 1.8 3.2 -1.8 -0.6
Blood White Count 0.9 6.7 8.2 2.9 -2.3
Heel T-Score 9.2 73.5 81.0 -8.1 -9.0
BMI 0.1 0.5 0.8 0.4 -0.9
Height 1.0 19.7 37.0 -6.1 -1.6
Waist Hip Ratio (WHR) 1.1 4.8 8.4 1.1 -2.9
Systolic Blood Pressure 0.1 0.6 0.6 0.8 0.8
Smoking Status 0.3 0.7 0.8 0.7 -0.9
Allergy or Eczema 2.4 6.3 12.6 -3.6 0.3
Cardiovascular Disease 0.8 2.6 4.9 -2.2 -0.5
Hypothyroidism (self reported) 1.4 3.1 3.3 1.8 -1.7
Respiratory disease 1.4 3.2 3.7 1.9 -1.7
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.5 -0.4 0.7
Lung FEV1/FVC ratio 0.1 0.6 1.1 -0.5 1.0
Lung FVC 3.4 17.4 26.2 -5.1 -2.9
Neuroticism 3.2 7.7 14.3 -3.8 -1.1
Chronotype (morning person) 1.1 2.4 2.9 1.4 -1.7
Hair Pigment 0.2 5.7 9.3 3.0 -1.5
Tanning 0.0 0.0 0.0 -0.0 0.0
Hand grip strength (left) 5.4 14.3 27.8 -5.3 1.0
Number of treatments/medications taken 1.6 2.9 3.7 1.9 -1.4
Average weekly spirits intake 0.8 1.0 1.8 1.4 -0.4
Sensitivity / hurt feelings 1.3 2.2 4.1 -2.0 -0.5
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.5 -1.2 -0.7
Hearing difficulty/problems: Yes 0.7 1.0 1.8 1.4 0.5
Relative age of first facial hair 0.1 0.1 0.2 0.5 -0.2
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 1.9 -1.4 0.6
Ever used hormone-replacement therapy (HRT) 2.8 3.6 6.5 2.6 -0.8
Ever had hysterectomy (womb removed) 0.4 0.5 0.9 0.3 -0.9
Systolic blood pressure, automated reading 0.6 1.8 3.2 1.8 0.7
Eye problems/disorders: Diabetes related eye disease 0.0 0.1 0.1 -0.1 0.3
Angina 2.1 2.7 2.8 1.7 -1.6
Medication for hormone replacement therapy 0.7 0.7 1.3 1.2 -0.3
Vitamin and mineral supplements 0.3 0.4 0.7 -0.8 -0.1
Supplements: Zinc 0.4 0.4 0.8 0.9 -0.3
Medication: Co-codamol 0.4 0.5 0.7 -0.8 0.5
Medication: Metformin 0.0 0.0 0.0 -0.1 -0.2
Diabetes (father) 0.4 0.5 1.1 0.2 1.0
Diabetes (mother) 0.3 0.4 0.6 0.8 -0.4
Severe depression (siblings) 0.2 0.2 0.3 -0.6 -0.3
Pack years adult smoking proportion 0.7 1.0 1.0 1.0 -1.0
Impedance of leg (right) 0.3 1.3 1.9 1.4 -0.9
Leg fat-free mass (left) 0.7 3.7 5.4 -2.3 -1.4
Trunk fat percentage 1.1 4.3 7.4 1.2 -2.7
Hand grip strength (right) 4.9 13.3 25.7 -5.1 1.0
Townsend deprivation index at recruitment 0.3 0.4 0.6 -0.5 0.8
Current tobacco smoking 0.6 0.9 1.4 1.2 -0.7
Average weekly fortified wine intake 0.3 0.3 0.6 0.1 0.8
Maternal smoking around birth 1.5 2.2 4.4 2.1 -0.1
Fed-up feelings 1.4 2.5 3.1 -1.8 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 3.3 -1.8 -0.8
Relative age voice broke 0.2 0.3 0.6 -0.0 0.8
Taking other prescription medications 2.6 4.1 5.8 1.5 -2.4
Age when periods started (menarche) 0.0 0.0 0.1 -0.1 -0.3
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.1 0.1 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 10.1 22.9 26.8 -4.4 -5.2
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 1.2 -1.1 -0.9
Qualifications: CSEs or equivalent 1.2 1.6 1.8 -1.4 -1.2
Serious illness, injury or assault to yourself 0.1 0.1 0.2 0.2 0.4
High blood pressure 0.2 0.5 0.9 -1.0 0.3
Hayfever, allergic rhinitis or eczema 2.4 5.1 9.6 -3.1 -0.8
Multivitamins +/- minerals 0.1 0.1 0.2 0.4 -0.2
Stomach or abdominal pain in last month 1.1 1.4 1.8 -1.3 1.0
Supplements: Glucosamine 0.2 0.2 0.4 -0.7 0.1
Diverticular disease/diverticulitis (self-reported) 3.2 3.9 4.9 2.2 -1.7
Medication: Atenolol 0.2 0.2 0.5 -0.7 0.0
Medication: Levothyroxine sodium 1.5 2.6 4.3 2.1 -1.0
Sitting height 2.0 14.1 28.2 -5.3 0.0
Chronic bronchitis/emphysema (father) 0.1 0.1 0.1 -0.4 0.2
High blood pressure (mother) 0.1 0.2 0.4 -0.1 0.6
Body mass index (BMI) 0.3 1.3 2.5 0.4 -1.6
Impedance of leg (left) 0.1 0.5 0.9 1.0 -0.2
Leg predicted mass (left) 0.7 3.6 5.3 -2.3 -1.3
Trunk fat mass 0.9 4.1 8.1 0.2 -2.8
Waist circumference 0.9 3.4 6.1 0.9 -2.5
Number of incorrect matches in round 0.5 0.8 1.6 1.3 -0.0
Past tobacco smoking 0.1 0.1 0.1 0.4 0.2
Alcohol usually taken with meals 1.2 1.9 2.0 1.4 1.4
Nervous feelings 0.3 0.5 0.6 -0.8 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.6 -1.3 -0.5
Hearing difficulty/problems with background noise 1.0 1.6 2.5 -0.8 -1.6
Hair/balding pattern: Pattern 2 0.7 0.9 1.8 -0.1 -1.3
Had menopause 2.4 3.0 5.7 -0.5 -2.4
Had other major operations 0.8 0.9 1.2 -1.1 -0.8
Forced vital capacity (FVC) 5.2 20.2 35.7 -6.0 -2.2
Heel bone mineral density (BMD) T-score, automated (right) 10.5 24.2 35.1 -3.6 -5.9
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 1.9 0.5 1.4
Qualifications: None of the above 0.1 0.3 0.5 0.7 -0.4
Financial difficulties in last 2 years 0.1 0.2 0.4 0.1 0.6
Mouth/teeth dental problems 1.1 1.8 2.8 0.8 1.7
Heart attack 0.2 0.3 0.6 -0.0 -0.7
Allergy 1.0 2.3 3.4 1.1 1.8
Pain all over the body in last month 0.2 0.2 0.4 0.6 -0.1
Diabetes (self-reported) 0.4 0.6 0.9 0.9 -0.6
Hayfever/allergic rhinitis (self-reported) 1.4 1.9 3.7 -1.9 -0.1
Medication: Ramipril 0.2 0.2 0.3 -0.5 -0.4
Medication: Simvastatin 2.0 2.9 4.9 -0.9 -2.2
Fluid intelligence score 0.4 0.9 1.5 0.5 1.2
Illnesses of siblings 0.7 1.0 1.7 1.3 0.6
Neuroticism score 2.1 4.5 7.5 -2.7 -1.2
Weight 0.8 3.9 4.4 -1.8 -2.1
Impedance of arm (right) 0.2 1.0 1.1 0.9 -1.0
Arm fat percentage (right) 0.7 2.7 3.3 1.5 -1.8
Trunk fat-free mass 1.4 8.0 15.1 -3.9 -1.0
Hip circumference 0.2 0.7 1.1 -0.6 -1.0
Time employed in main current job 0.4 0.5 0.6 0.8 -0.5
Alcohol intake versus 10 years previously 0.4 0.6 1.1 1.1 -0.2
Father’s age at death 1.2 1.6 3.2 1.8 0.1
Worrier / anxious feelings 1.4 2.7 5.5 -2.3 -0.0
Frequency of tiredness / lethargy in last 2 weeks 3.9 6.4 9.4 -3.1 -1.9
Falls in the last year 1.1 1.4 2.5 0.6 1.6
Hair/balding pattern: Pattern 3 0.2 0.4 0.5 -0.5 0.7
Number of live births 0.4 0.5 0.7 -0.6 -0.8
Forced expiratory volume in 1-second (FEV1) 5.6 19.0 36.5 -6.0 -1.2
Pulse rate 0.1 0.1 0.2 0.4 -0.2
Happiness 1.4 1.7 2.2 -1.5 1.1
Noisy workplace 0.0 0.0 0.0 -0.1 0.2
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.7 0.8 -0.4
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.2 -1.5 0.1
Mouth/teeth dental problems: Dentures 2.5 4.2 8.2 0.4 -2.9
Asthma 2.2 4.3 4.5 2.1 -2.0
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.0 -1.0 0.7
Medication: Cholesterol lowering 1.2 1.8 3.4 0.5 -1.9
Depression (self-reported) 0.5 0.6 0.9 -0.6 1.0
Medication: Lansoprazole 0.9 1.0 1.5 0.7 -1.2
Prospective memory result 1.7 2.2 2.4 1.6 -1.4
Lung cancer (father) 0.9 1.1 2.0 1.4 0.4
Illnesses of mother 0.1 0.1 0.1 -0.3 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 6.0 19.3 38.6 -6.2 -0.1
Pulse wave Arterial Stiffness index 1.2 1.5 1.6 1.2 -1.3
Impedance of arm (left) 0.3 1.4 1.4 1.2 -1.1
Arm fat mass (right) 0.4 1.5 3.1 0.1 -1.8
Trunk predicted mass 1.3 7.7 14.5 -3.8 -0.9
Standing height 1.5 15.1 27.5 -5.2 -1.6
Length of working week for main job 1.8 1.9 3.8 0.2 2.0
Exposure to tobacco smoke at home 0.2 0.3 0.4 -0.4 0.6
Breastfed as a baby 0.3 0.3 0.6 0.8 0.3
Tense / ‘highly strung’ 0.5 0.8 1.6 -1.3 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.0 -0.1 -1.0
Hair/balding pattern: Pattern 4 3.2 7.8 15.6 -4.0 -0.2
Birth weight of first child 1.5 2.8 5.1 -2.3 -0.7
Peak expiratory flow (PEF) 3.0 7.1 13.2 -3.6 -0.9
Pulse wave reflection index 0.6 0.8 0.9 -0.8 -1.0
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.5 -0.4 0.7
Loud music exposure frequency 0.1 0.1 0.2 0.4 -0.2
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.0 -0.1 0.2
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.2 0.2 -0.5
Blood clot in the leg (DVT) 0.5 0.6 1.1 -1.1 0.3
Medication: Paracetamol 0.1 0.1 0.2 -0.5 -0.1
Headache pain in last month 1.5 2.5 5.0 -2.2 0.0
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.4 0.1 0.6
Glaucoma (self-reported) 0.1 0.1 0.1 -0.2 0.3
Gout (self-reported) 0.3 0.4 0.5 -0.7 0.7
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 2.7 1.6 -1.6
Medication: Amlodipine 0.4 0.6 0.7 0.6 0.9
Medication: Ventolin 100micrograms inhaler 4.1 5.3 7.2 2.7 -1.9
Birth weight 2.7 5.9 11.8 -3.4 0.0
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 0.5 -0.3
High blood pressure (siblings) 0.7 1.1 1.9 -0.4 1.4
Forced vital capacity (FVC), Best measure 4.9 17.8 34.7 -5.9 -1.0
Body fat percentage 1.2 4.7 6.8 1.6 -2.6
Leg fat percentage (right) 1.4 5.2 5.3 2.2 -2.3
Arm fat-free mass (right) 0.9 4.6 8.5 -2.9 -0.9
Exposure to tobacco smoke outside home 0.2 0.3 0.6 0.7 0.3
Comparative body size at age 10 0.7 2.0 2.6 1.6 -1.2
Number of full brothers 0.0 0.0 0.1 0.2 0.0
Worry too long after embarrassment 2.0 3.3 6.1 -2.5 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.6 0.5 1.3
Wheeze or whistling in the chest in last year 0.4 0.7 1.3 1.1 -0.4
Number of children fathered 0.4 0.5 1.0 1.0 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 1.7 -0.3 1.3
Age at first live birth 0.6 1.0 2.0 -1.4 0.1
Pulse wave peak to peak time 1.6 1.9 2.3 -1.5 1.2
Health satisfaction 0.5 0.6 1.3 -1.1 -0.1
Shortness of breath walking on level ground 1.2 1.4 1.9 1.0 -1.4
Qualifications: College or University degree 0.1 0.3 0.3 -0.6 0.6
Eye problems/disorders: None of the above 0.1 0.1 0.1 0.3 0.4
Mouth/teeth dental problems: Loose teeth 2.7 3.2 5.0 1.1 2.2
Emphysema/chronic bronchitis 1.5 1.7 3.3 1.8 -0.2
Medication for pain relief, constipation, heartburn 0.2 0.4 0.7 0.3 0.8
Neck or shoulder pain in last month 1.3 1.9 2.8 -1.7 1.0
Medication: Blood pressure 0.1 0.1 0.1 0.2 -0.4
Angina (self-reported) 2.3 3.0 3.0 1.7 -1.7
Migraine (self-reported) 1.0 1.2 1.4 -1.2 -1.0
Medication: Ibuprofen 0.5 0.6 0.7 -0.8 0.8
Medication: Allopurinol 0.1 0.1 0.2 0.5 0.3
Medication: Omeprazole 0.0 0.0 0.0 -0.1 -0.2
Medication: Seretide 50 evohaler 3.5 4.0 6.6 2.6 -1.2
Mean time to correctly identify matches 0.2 0.4 0.7 0.8 0.4
Heart disease (mother) 0.9 1.1 2.1 -0.0 -1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.9 -0.0 1.4
Whole body fat mass 0.9 3.6 7.1 0.3 -2.7
Leg fat mass (right) 0.8 3.0 4.7 1.2 -2.2
Arm predicted mass (right) 0.9 4.7 8.0 -2.8 -1.2
Pulse rate, automated reading 0.2 0.5 0.6 0.8 0.7
Alcohol intake frequency. 0.2 0.5 0.6 0.8 -0.7
Comparative height size at age 10 1.7 9.1 15.7 -4.0 -1.6
Number of full sisters 0.6 0.7 1.5 -0.1 1.2
Suffer from ‘nerves’ 1.2 1.9 2.9 -1.0 -1.7
Overall health rating 0.0 0.0 0.1 -0.2 0.1
Chest pain or discomfort 0.0 0.1 0.1 0.3 -0.1
Had major operations 1.3 1.5 2.9 0.2 1.7
Age at last live birth 0.4 0.6 1.1 -1.0 0.4
Family relationship satisfaction 1.3 1.6 2.8 0.6 1.7
Leg pain on walking 0.1 0.1 0.1 -0.1 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.1 0.3 0.1
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.6 1.3 0.5
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.1 -0.0 0.3
Medication: Aspirin 0.8 1.0 1.9 -0.5 -1.4
Supplements: Vitamin C 0.7 0.9 1.5 0.6 1.2
Knee pain experienced in last month 0.8 1.3 2.6 -1.6 0.0
Hypertension (Self-reported) 0.1 0.3 0.6 -0.8 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.6 0.1 0.8
Illnesses of father: Heart disease 2.2 3.0 5.8 -2.4 -0.5
Illnesses of siblings: Diabetes 1.6 2.0 3.8 0.4 -2.0
Smoking status: Previous 0.4 0.7 0.7 -0.8 0.8
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.6 6.3 -2.5 0.9
Whole body fat-free mass 1.1 6.5 11.6 -3.4 -1.1
Leg fat-free mass (right) 0.8 4.5 8.1 -2.9 -0.9
Arm fat percentage (left) 0.9 3.6 4.1 1.8 -2.0
Average weekly red wine intake 3.3 4.8 9.0 -3.0 -0.8
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.3 -0.5 -0.1
Mood swings 2.5 4.5 9.0 -3.0 -0.2
Loneliness, isolation 1.2 1.6 1.8 -1.4 -1.2
Long-standing illness, disability or infirmity 0.2 0.3 0.6 0.8 -0.0
Ever had bowel cancer screening 1.9 2.2 4.4 0.0 -2.1
Diabetes diagnosed by doctor 0.3 0.5 0.9 1.0 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 -0.5 -0.1
Friendships satisfaction 1.2 1.4 2.9 -0.1 1.7
Qualifications: nursing, teaching 0.2 0.2 0.2 -0.5 -0.5
Commuting to job workplace: Walk 1.7 1.9 3.4 -1.9 -0.6
Eye problems/disorders: Cataract 0.3 0.4 0.8 0.0 -0.9
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 2.5 -1.6 -1.1
Medication for cholesterol 0.4 0.5 0.8 -0.9 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.6 0.8 -0.0
Back pain experienced in last month 0.1 0.1 0.1 -0.3 0.3
Mineral and other dietary supplements 0.3 0.4 0.5 -0.5 0.7
Breast cancer (self-reported) 1.7 2.0 3.9 -2.0 -0.4
Asthma (self-reported) 1.9 3.8 4.4 2.1 -1.8
Osteoporosis (self-reported) 4.6 5.6 7.9 1.8 2.8
Osteoarthritis (self-reported) 0.3 0.4 0.7 -0.3 0.8
Medication: Aspirin 0.9 1.1 2.0 -0.5 -1.4
Medication: Gliclazide 1.3 1.4 2.8 0.3 -1.7
Illnesses of father: None of the above (group 1) 1.3 1.6 2.4 1.6 0.9
Smoking status: Current 0.9 1.5 2.1 1.4 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 7.2 15.3 27.0 -5.2 -1.9
Whole body water mass 1.1 6.4 11.8 -3.4 -1.0
Leg predicted mass (right) 0.8 4.4 8.0 -2.8 -0.9
Arm fat mass (left) 0.4 1.8 3.7 0.2 -1.9
Number of self-reported non-cancer illnesses 0.4 0.7 1.2 0.5 -1.1
Average weekly champagne plus white wine intake 0.9 1.3 2.5 -0.4 1.6
Miserableness 2.6 4.6 7.1 -2.7 -1.5
Guilty feelings 0.9 1.4 1.9 -0.9 -1.4
Wears glasses or contact lenses 0.4 0.5 0.9 -1.0 -0.2
Ever taken oral contraceptive pill 0.4 0.5 0.5 -0.7 0.7
Hearing aid user 0.1 0.1 0.2 0.4 0.3
Mother’s age at death 0.5 0.6 0.7 -0.8 0.8
Financial situation satisfaction 0.8 1.0 2.0 0.1 1.4
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 -0.3 0.2
Commuting to job workplace: Public transport 0.4 0.5 1.0 -1.0 0.0
Eye problems/disorders: Glaucoma 0.0 0.0 0.0 -0.2 0.2
Medication: Blood pressure 0.2 0.4 0.5 -0.5 0.7
Pain type(s) experienced in last month: Hip pain 0.5 0.7 1.3 -0.2 -1.2
Supplements: Fish oil (including cod liver oil) 1.2 1.6 1.8 1.2 -1.3
High cholesterol (Self-reported) 1.1 1.9 3.6 0.4 -1.9
Medication: Bendroflumethiazide 0.2 0.2 0.3 0.6 -0.4
Medication: Paracetamol 0.0 0.0 0.0 0.1 0.1
Medication: Lisinopril 0.5 0.7 1.1 0.6 -1.0
Medication: Atorvastatin 1.8 2.2 4.3 0.3 -2.1
Illnesses of father: High blood pressure 2.4 3.0 5.9 -2.4 0.3
Alcohol drinker status: Never 0.5 0.6 1.1 -0.3 -1.1
Ever smoked 0.1 0.2 0.3 -0.6 -0.1
Basal metabolic rate 1.0 5.4 9.2 -3.0 -1.3
Leg fat percentage (left) 1.1 4.0 4.3 2.1 -1.9
Arm fat-free mass (left) 1.2 5.9 10.3 -3.2 -1.3
Number of operations (self-reported) 0.0 0.1 0.1 -0.2 -0.3
Average weekly beer plus cider intake 0.5 0.7 1.2 1.1 -0.4
Irritability 1.0 1.7 3.0 -1.7 -0.6
Risk taking 1.8 2.6 5.1 2.3 0.4
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.2 -1.5 -0.3
Fractured/broken bones in last 5 years 0.6 0.7 1.4 1.2 -0.2
Age started oral contraceptive pill 0.7 0.8 1.5 1.2 0.4
Diastolic blood pressure, automated reading 6.2 19.4 38.7 -6.2 -0.0
Ever depressed for a whole week 0.2 0.2 0.4 0.3 0.6
Unable to work because of sickness or disability 0.1 0.2 0.3 -0.2 -0.5
Commuting to job workplace: Cycle 2.9 3.5 6.7 -2.6 0.6
Myopia 2.7 3.9 5.6 1.5 2.4
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.2 0.5 0.1
Cholesterol lowering medication 0.6 0.8 1.5 -0.4 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.4 -0.7 -0.1
Pain experienced in last month 2.5 4.2 7.8 2.8 0.8
Supplements: Calcium 1.3 1.4 2.7 1.6 0.3
Basal cell carcinoma (self-reported) 1.8 2.2 3.9 -0.6 -2.0
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.4 0.1 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.1 -1.1 0.1
Heart disease (siblings) 2.8 3.4 3.6 -1.9 -1.8
Alcohol drinker status: Previous 0.1 0.1 0.2 0.0 0.4
Pack years of smoking 1.4 2.0 2.9 1.0 -1.7
Impedance of whole body 0.2 0.8 1.0 1.0 -0.7
Leg fat mass (left) 0.7 2.6 4.1 1.1 -2.0
Arm predicted mass (left) 1.2 6.3 11.4 -3.4 -1.1