Hub : Traits :

Forced expiratory volume in 1-second (FEV1), predicted percentage

701 significantly associated models · 131 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 25752617 27595862 3 1 2.2e-08 4.4e-08 2.1e-02 82 CNKSR1
2 3 49145304 50546340 1 1 3.7e-07 2.7e-06 3.9e-01 97 UBA7
3 3 56843028 58241059 1 1 5.8e-08 1.2e-08 7.0e-04 65 PDE12
4 3 133518198 134987090 1 1 1.5e-07 6.7e-07 8.3e-01 100 CEP63
5 4 105598022 107511296 3 2 8.8e-15 8.6e-15 1.0e+00 100 INTS12 PPA2
6 4 112466269 113876522 1 1 3.6e-07 4.0e-07 8.7e-02 89 AP1AR
7 4 144758204 146276932 2 1 3.1e-12 3.0e-24 1.4e-13 47 RP11-361D14.2
8 5 147063674 148712150 2 1 1.8e-11 2.2e-15 7.8e-06 68 FBXO38
9 5 156131251 157697754 1 1 8.3e-09 1.2e-08 2.5e-03 72 ADAM19
10 6 25266147 26689223 3 3 3.8e-10 1.1e-16 6.8e-02 95 TRIM38 U91328.19 U91328.21
11 6 34399814 35950210 2 1 4.4e-08 2.0e-07 3.3e-02 83 TCP11
12 6 141787794 143235252 1 1 3.2e-07 1.6e-11 1.2e-06 48 VTA1
13 8 8165004 9669775 1 1 2.6e-07 1.5e-07 1.9e-02 80 ERI1
14 10 11515875 13569805 3 1 1.1e-12 1.1e-13 1.8e-02 90 CDC123
15 10 74808045 76323150 3 1 8.9e-08 4.4e-08 1.0e+00 100 SEC24C
16 10 102045656 103428898 1 1 8.3e-08 9.3e-08 4.0e-02 85 MRPL43
17 10 104939215 106371784 2 1 1.2e-07 3.3e-07 1.0e+00 100 RP11-541N10.3
18 11 61627881 63110149 7 1 1.8e-10 9.0e-10 1.0e+00 100 EML3
19 11 72414189 74006925 1 1 1.7e-07 1.9e-06 2.4e-01 94 FAM168A
20 12 27587038 29432481 2 2 7.1e-13 3.9e-12 1.0e+00 100 CCDC91 RP11-967K21.1
21 14 92286262 93847625 1 1 1.4e-08 6.2e-08 1.0e+00 100 RIN3
22 15 78032707 79886142 7 1 1.8e-16 2.2e-17 2.8e-02 93 PSMA4
23 15 83167559 84478679 3 2 6.3e-08 4.2e-10 1.2e-02 84 RP11-382A20.2 WHAMM
24 16 2868641 4395241 2 2 1.1e-09 9.6e-07 3.0e-01 96 CLUAP1 RP11-461A8.4
25 16 29580611 31892919 21 1 2.1e-13 6.4e-11 8.0e-01 100 STX1B
26 16 69062879 70840490 3 1 1.5e-09 5.3e-09 1.2e-01 93 NOB1
27 16 74578110 76197034 3 1 2.7e-09 9.7e-09 6.7e-01 99 CFDP1
28 17 36211659 38770286 11 2 1.2e-11 2.3e-11 4.0e-01 98 PCGF2 PGAP3
29 17 42607368 45796313 22 1 7.0e-18 8.1e-17 4.2e-02 94 MAPT
30 17 72819004 74267010 2 1 1.9e-09 3.3e-09 3.6e-01 98 LLGL2
31 20 9925555 11347455 1 1 2.1e-07 2.3e-04 9.6e-04 20 JAG1
32 20 24485525 26307797 7 1 1.6e-09 4.4e-09 3.3e-01 97 PYGB
33 20 61576647 62912463 5 1 1.3e-11 1.2e-11 1.0e+00 100 ARFRP1
34 22 17581838 19203078 1 1 1.8e-12 1.7e-14 1.0e-03 82 MICAL3
35 22 50313438 51219006 1 1 1.4e-07 6.2e-06 3.7e-02 79 CPT1B

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.13 1 1 3.0 0.00 1.0e+00 STX1B
Crohns Disease (2017) 2.07 3 3 9.1 0.00 1.0e+00 ARFRP1 PGAP3 SEC24C
Irritable Bowel Disease (IBD) 2.26 3 2 6.1 0.00 1.0e+00 ARFRP1 PGAP3 UBA7
Ulcerative Colitis (UC) 1.93 3 2 6.1 0.00 1.0e+00 ARFRP1 PGAP3 UBA7
Verbal and Numeric Reasoning (VNR) 2.30 3 3 9.1 0.00 1.0e+00 PPA2 U91328.21 UBA7
Breast Cancer 1.98 2 2 6.1 0.00 1.0e+00 MAPT RIN3
Ovarian Cancer 1.73 1 1 3.0 0.00 1.0e+00 MAPT
Prostate Cancer 2.10 2 1 3.0 0.00 1.0e+00 ARFRP1 UBA7
Age at First Birth 1.90 1 1 3.0 0.00 1.0e+00 UBA7
Crohns Disease (2012) 2.13 1 1 3.0 0.00 1.0e+00 ARFRP1
HDL Cholesterol 1.71 1 1 3.0 0.00 1.0e+00 PGAP3
Lupus 1.73 1 0 0.0 0.00 1.0e+00 TCP11
Neuroticism 2.39 2 1 3.0 0.00 1.0e+00 ERI1 MAPT
Primary Biliary Cirrhosis 2.34 1 0 0.0 0.00 1.0e+00 MAPT
Schizophrenia 1.07 2 0 0.0 0.00 1.0e+00 ERI1 PSMA4
Triglycerides 1.25 1 0 0.0 0.00 1.0e+00 STX1B
Ulcerative Colitis 2.00 2 1 3.0 0.00 1.0e+00 ARFRP1 PGAP3
Blood Eosinophil Count 1.34 5 3 9.1 0.34 5.7e-01 MAPT NOB1 PCGF2 PGAP3 RIN3
Blood Platelet Count 1.23 10 6 18.2 0.72 1.9e-02 ARFRP1 CFDP1 CPT1B MAPT PDE12 PGAP3 PYGB RIN3 RP11-361D14.2 TCP11
Blood Red Count 2.86 7 6 18.2 0.67 1.0e-01 ARFRP1 CPT1B MAPT NOB1 PGAP3 RP11-541N10.3 STX1B
Blood White Count 4.22 11 7 21.2 0.56 7.3e-02 ARFRP1 FBXO38 MAPT MICAL3 NOB1 PGAP3 PPA2 RIN3 STX1B TCP11 UBA7
Heel T-Score 1.92 13 6 18.2 -0.38 2.0e-01 ARFRP1 CEP63 EML3 JAG1 MAPT MRPL43 PCGF2 PDE12 RIN3 RP11-361D14.2 SEC24C STX1B WHAMM
BMI 2.18 7 4 12.1 0.65 1.1e-01 CCDC91 CPT1B NOB1 PYGB STX1B TCP11 UBA7
Height 2.82 17 14 42.4 -0.18 4.8e-01 ARFRP1 CCDC91 CDC123 CEP63 CFDP1 CNKSR1 JAG1 LLGL2 MAPT MICAL3 NOB1 PPA2 PYGB RP11-361D14.2 RP11-382A20.2 RP11-967K21.1 TCP11
Waist Hip Ratio (WHR) 2.49 5 3 9.1 0.52 3.7e-01 CCDC91 CNKSR1 EML3 MAPT RP11-361D14.2
Systolic Blood Pressure 1.92 7 3 9.1 0.24 6.1e-01 CDC123 CEP63 CFDP1 MAPT MICAL3 RIN3 RP11-541N10.3
Smoking Status 2.20 4 1 3.0 0.99 8.0e-03 ARFRP1 NOB1 PGAP3 UBA7
Allergy or Eczema 2.00 2 2 6.1 0.00 1.0e+00 ARFRP1 PGAP3
Cardiovascular Disease 1.47 3 1 3.0 0.00 1.0e+00 CFDP1 STX1B TCP11
Hypothyroidism (self reported) 1.09 1 0 0.0 0.00 1.0e+00 RIN3
Respiratory disease 4.55 6 1 3.0 0.89 1.8e-02 ADAM19 ARFRP1 PCGF2 PGAP3 RIN3 UBA7
Type 2 Diabetes (T2D) 1.94 2 0 0.0 0.00 1.0e+00 FBXO38 NOB1
Lung FEV1/FVC ratio 14.18 20 18 54.5 -0.91 3.0e-08 ADAM19 AP1AR CDC123 CFDP1 FAM168A FBXO38 INTS12 LLGL2 MICAL3 PCGF2 PDE12 PPA2 PSMA4 RP11-361D14.2 RP11-382A20.2 SEC24C TCP11 UBA7 VTA1 WHAMM
Lung FVC 12.06 30 27 81.8 -0.94 6.6e-15 ARFRP1 CCDC91 CDC123 CEP63 CLUAP1 CNKSR1 EML3 FBXO38 INTS12 JAG1 LLGL2 MAPT MICAL3 NOB1 PDE12 PGAP3 PPA2 PSMA4 PYGB RIN3 RP11-361D14.2 RP11-382A20.2 RP11-461A8.4 RP11-541N10.3 RP11-967K21.1 SEC24C STX1B TCP11 UBA7 WHAMM
Neuroticism 2.49 4 1 3.0 0.52 4.8e-01 MAPT PCGF2 STX1B UBA7
Hair Pigment 0.13 1 0 0.0 0.00 1.0e+00 MAPT
Hand grip strength (left) 2.46 5 3 9.1 0.59 3.0e-01 JAG1 MAPT NOB1 PCGF2 STX1B
Number of treatments/medications taken 1.92 2 1 3.0 0.00 1.0e+00 TCP11 UBA7
Sensitivity / hurt feelings 2.15 2 1 3.0 0.00 1.0e+00 ERI1 MAPT
Relative age of first facial hair 2.05 2 1 3.0 0.00 1.0e+00 MAPT UBA7
Systolic blood pressure, automated reading 2.25 5 3 9.1 -0.40 5.0e-01 CFDP1 ERI1 MAPT PPA2 RP11-541N10.3
Vitamin and mineral supplements 1.86 1 0 0.0 0.00 1.0e+00 U91328.19
Medication: Co-codamol 1.34 1 0 0.0 0.00 1.0e+00 UBA7
Pack years adult smoking proportion 6.88 1 1 3.0 0.00 1.0e+00 PSMA4
Impedance of leg (right) 2.40 8 5 15.2 0.03 9.5e-01 CCDC91 ERI1 PPA2 RIN3 RP11-382A20.2 SEC24C STX1B UBA7
Leg fat-free mass (left) 2.48 9 6 18.2 0.01 9.8e-01 CNKSR1 ERI1 PPA2 RIN3 RP11-361D14.2 STX1B TRIM38 U91328.19 UBA7
Trunk fat percentage 2.80 10 8 24.2 -0.97 1.8e-06 ARFRP1 EML3 NOB1 PYGB RIN3 STX1B TCP11 TRIM38 U91328.19 UBA7
Hand grip strength (right) 2.15 5 3 9.1 0.66 2.3e-01 JAG1 MAPT NOB1 PCGF2 STX1B
Current tobacco smoking 2.28 1 1 3.0 0.00 1.0e+00 ARFRP1
Fed-up feelings 2.26 2 1 3.0 0.00 1.0e+00 MAPT UBA7
Relative age voice broke 1.47 1 1 3.0 0.00 1.0e+00 MAPT
Taking other prescription medications 1.85 1 1 3.0 0.00 1.0e+00 UBA7
Age when periods started (menarche) 1.94 3 2 6.1 0.00 1.0e+00 MAPT NOB1 UBA7
Heel bone mineral density (BMD) T-score, automated (left) 2.04 4 1 3.0 -0.02 9.8e-01 ERI1 JAG1 MAPT U91328.19
High blood pressure 1.72 3 1 3.0 0.00 1.0e+00 CFDP1 ERI1 STX1B
Hayfever, allergic rhinitis or eczema 2.34 3 2 6.1 0.00 1.0e+00 ARFRP1 PGAP3 U91328.19
Medication: Levothyroxine sodium 1.95 2 1 3.0 0.00 1.0e+00 ERI1 U91328.19
Sitting height 3.75 10 9 27.3 0.40 2.5e-01 CCDC91 CNKSR1 JAG1 MAPT NOB1 PPA2 PYGB RP11-361D14.2 RP11-967K21.1 U91328.19
Chronic bronchitis/emphysema (father) 3.67 1 1 3.0 0.00 1.0e+00 PSMA4
High blood pressure (mother) 1.78 1 0 0.0 0.00 1.0e+00 CFDP1
Body mass index (BMI) 2.88 9 6 18.2 -0.82 6.9e-03 CCDC91 ERI1 NOB1 PYGB STX1B TCP11 TRIM38 U91328.19 UBA7
Impedance of leg (left) 2.60 9 5 15.2 0.02 9.6e-01 CCDC91 ERI1 MAPT NOB1 PPA2 RIN3 RP11-382A20.2 STX1B UBA7
Leg predicted mass (left) 2.48 8 6 18.2 0.08 8.5e-01 CNKSR1 ERI1 PPA2 RIN3 RP11-361D14.2 STX1B U91328.19 UBA7
Trunk fat mass 2.78 11 8 24.2 -0.82 2.1e-03 ARFRP1 EML3 ERI1 NOB1 PYGB RP11-361D14.2 STX1B TCP11 TRIM38 U91328.19 UBA7
Waist circumference 2.23 8 5 15.2 -0.98 1.9e-05 ARFRP1 FBXO38 NOB1 PYGB STX1B TCP11 U91328.19 UBA7
Number of incorrect matches in round 1.98 1 0 0.0 0.00 1.0e+00 STX1B
Past tobacco smoking 1.69 2 0 0.0 0.00 1.0e+00 NOB1 PGAP3
Nervous feelings 2.56 4 3 9.1 -0.08 9.2e-01 ERI1 FBXO38 MAPT U91328.19
Frequency of tenseness / restlessness in last 2 weeks 2.11 2 1 3.0 0.00 1.0e+00 MAPT UBA7
Hearing difficulty/problems with background noise 1.82 2 0 0.0 0.00 1.0e+00 MAPT U91328.19
Hair/balding pattern: Pattern 2 1.45 1 0 0.0 0.00 1.0e+00 MAPT
Had other major operations 1.48 1 0 0.0 0.00 1.0e+00 PPA2
Forced vital capacity (FVC) 7.96 28 20 60.6 0.97 7.8e-17 ARFRP1 CCDC91 CDC123 CLUAP1 CNKSR1 EML3 INTS12 JAG1 MAPT MICAL3 NOB1 PDE12 PPA2 PSMA4 PYGB RIN3 RP11-361D14.2 RP11-382A20.2 RP11-461A8.4 RP11-541N10.3 RP11-967K21.1 SEC24C STX1B TCP11 TRIM38 U91328.21 UBA7 WHAMM
Heel bone mineral density (BMD) T-score, automated (right) 1.97 2 1 3.0 0.00 1.0e+00 ERI1 U91328.19
Ever unenthusiastic/disinterested for a whole week 1.60 1 0 0.0 0.00 1.0e+00 UBA7
Qualifications: None of the above 1.62 2 1 3.0 0.00 1.0e+00 PPA2 UBA7
Mouth/teeth dental problems 1.36 2 0 0.0 0.00 1.0e+00 ERI1 MAPT
Allergy 2.75 3 3 9.1 0.00 1.0e+00 ARFRP1 PGAP3 U91328.19
Pain all over the body in last month 1.99 2 0 0.0 0.00 1.0e+00 ARFRP1 UBA7
Diabetes (self-reported) 1.84 2 0 0.0 0.00 1.0e+00 CLUAP1 FBXO38
Hayfever/allergic rhinitis (self-reported) 1.46 1 0 0.0 0.00 1.0e+00 U91328.19
Fluid intelligence score 2.41 4 2 6.1 0.10 9.0e-01 PPA2 STX1B U91328.21 UBA7
Illnesses of siblings 1.73 1 0 0.0 0.00 1.0e+00 STX1B
Neuroticism score 2.96 5 2 6.1 -0.27 6.6e-01 ERI1 FBXO38 MAPT STX1B UBA7
Weight 2.72 11 6 18.2 -0.50 1.1e-01 ARFRP1 ERI1 NOB1 PPA2 PYGB RP11-361D14.2 STX1B TCP11 TRIM38 U91328.19 UBA7
Impedance of arm (right) 2.25 6 6 18.2 0.20 7.0e-01 EML3 ERI1 MAPT RIN3 STX1B UBA7
Arm fat percentage (right) 2.93 11 7 21.2 -0.68 2.2e-02 ARFRP1 CCDC91 EML3 ERI1 NOB1 PYGB RP11-967K21.1 STX1B TCP11 U91328.19 UBA7
Trunk fat-free mass 2.60 9 6 18.2 0.11 7.9e-01 CCDC91 CNKSR1 PPA2 RIN3 RP11-361D14.2 RP11-967K21.1 STX1B U91328.19 UBA7
Hip circumference 3.10 9 7 21.2 -0.68 4.3e-02 ARFRP1 ERI1 NOB1 RP11-361D14.2 STX1B TCP11 TRIM38 U91328.19 UBA7
Father's age at death 2.55 2 1 3.0 0.00 1.0e+00 ERI1 PSMA4
Worrier / anxious feelings 2.26 3 1 3.0 0.00 1.0e+00 ERI1 MAPT STX1B
Hair/balding pattern: Pattern 3 1.77 1 1 3.0 0.00 1.0e+00 MAPT
Forced expiratory volume in 1-second (FEV1) 12.56 35 30 90.9 0.97 2.7e-21 ADAM19 ARFRP1 CCDC91 CDC123 CEP63 CFDP1 CLUAP1 CNKSR1 EML3 ERI1 FAM168A FBXO38 INTS12 JAG1 LLGL2 MAPT MICAL3 NOB1 PCGF2 PDE12 PPA2 PSMA4 PYGB RIN3 RP11-361D14.2 RP11-382A20.2 RP11-541N10.3 RP11-967K21.1 SEC24C STX1B TCP11 TRIM38 U91328.21 UBA7 WHAMM
Pulse rate 1.62 1 0 0.0 0.00 1.0e+00 EML3
Qualifications: A levels/AS levels or equivalent 1.61 2 1 3.0 0.00 1.0e+00 PPA2 UBA7
Mouth/teeth dental problems: Dentures 2.71 5 1 3.0 -0.95 1.5e-02 ERI1 PSMA4 TRIM38 U91328.19 UBA7
Asthma 4.71 4 3 9.1 -0.97 2.5e-02 ADAM19 PGAP3 TRIM38 U91328.21
Medication: Ibuprofen (e.g. Nurofen) 1.76 2 0 0.0 0.00 1.0e+00 MAPT U91328.21
Lung cancer (father) 2.39 1 1 3.0 0.00 1.0e+00 PSMA4
Forced expiratory volume in 1-second (FEV1), Best measure 13.21 35 30 90.9 0.97 1.1e-21 ADAM19 ARFRP1 CCDC91 CDC123 CEP63 CFDP1 CLUAP1 CNKSR1 EML3 ERI1 FAM168A FBXO38 INTS12 JAG1 LLGL2 MAPT MICAL3 NOB1 PCGF2 PDE12 PPA2 PSMA4 PYGB RIN3 RP11-361D14.2 RP11-382A20.2 RP11-461A8.4 RP11-967K21.1 SEC24C STX1B TCP11 TRIM38 U91328.21 UBA7 WHAMM
Impedance of arm (left) 2.11 6 6 18.2 0.26 6.2e-01 EML3 ERI1 MAPT RIN3 STX1B UBA7
Arm fat mass (right) 2.79 9 7 21.2 -0.97 1.4e-05 ARFRP1 ERI1 NOB1 PYGB STX1B TCP11 TRIM38 U91328.19 UBA7
Trunk predicted mass 2.59 9 6 18.2 0.11 7.9e-01 CCDC91 CNKSR1 PPA2 RIN3 RP11-361D14.2 RP11-967K21.1 STX1B U91328.19 UBA7
Standing height 2.77 15 12 36.4 0.20 4.8e-01 CCDC91 CEP63 CFDP1 CNKSR1 ERI1 JAG1 LLGL2 MAPT NOB1 PPA2 RP11-361D14.2 RP11-382A20.2 RP11-967K21.1 TCP11 U91328.19
Exposure to tobacco smoke at home 2.02 1 1 3.0 0.00 1.0e+00 UBA7
Tense / 'highly strung' 1.96 2 0 0.0 0.00 1.0e+00 ERI1 STX1B
Seen doctor (GP) for nerves, anxiety, tension or depression 1.58 1 0 0.0 0.00 1.0e+00 U91328.21
Hair/balding pattern: Pattern 4 2.90 1 1 3.0 0.00 1.0e+00 MAPT
Birth weight of first child 3.15 4 3 9.1 0.98 1.6e-02 CFDP1 PPA2 RP11-361D14.2 TCP11
Peak expiratory flow (PEF) 7.61 14 8 24.2 0.96 9.8e-08 ADAM19 CDC123 CFDP1 ERI1 FAM168A FBXO38 MAPT NOB1 PCGF2 PDE12 PPA2 RP11-361D14.2 TCP11 U91328.21
Ever highly irritable/argumentative for 2 days 1.62 1 0 0.0 0.00 1.0e+00 UBA7
Medication: Paracetamol 3.06 3 2 6.1 0.00 1.0e+00 MAPT U91328.21 UBA7
Headache pain in last month 2.78 3 2 6.1 0.00 1.0e+00 CFDP1 MAPT U91328.21
Hypothyroidism/myxoedema (self-reported) 2.06 2 2 6.1 0.00 1.0e+00 ERI1 U91328.19
Medication: Ventolin 100micrograms inhaler 2.71 1 1 3.0 0.00 1.0e+00 PGAP3
Birth weight 2.08 3 1 3.0 0.00 1.0e+00 PPA2 RP11-361D14.2 TCP11
Chronic bronchitis/emphysema (mother) 3.05 1 1 3.0 0.00 1.0e+00 PSMA4
High blood pressure (siblings) 1.86 1 0 0.0 0.00 1.0e+00 STX1B
Forced vital capacity (FVC), Best measure 8.19 29 20 60.6 0.97 1.5e-17 ARFRP1 CCDC91 CDC123 CLUAP1 CNKSR1 EML3 FBXO38 INTS12 JAG1 MAPT MICAL3 NOB1 PDE12 PPA2 PSMA4 PYGB RIN3 RP11-361D14.2 RP11-382A20.2 RP11-461A8.4 RP11-541N10.3 RP11-967K21.1 SEC24C STX1B TCP11 TRIM38 U91328.21 UBA7 WHAMM
Body fat percentage 2.92 11 8 24.2 -0.98 2.4e-07 ARFRP1 EML3 ERI1 NOB1 PYGB RIN3 STX1B TCP11 TRIM38 U91328.19 UBA7
Leg fat percentage (right) 2.92 10 8 24.2 -0.98 5.4e-07 ARFRP1 ERI1 NOB1 PYGB RIN3 STX1B TCP11 TRIM38 U91328.19 UBA7
Arm fat-free mass (right) 2.63 8 7 21.2 0.11 7.9e-01 CNKSR1 PPA2 RIN3 RP11-361D14.2 RP11-967K21.1 STX1B U91328.19 UBA7
Comparative body size at age 10 2.13 5 2 6.1 -0.99 6.1e-04 ERI1 RP11-382A20.2 STX1B U91328.19 U91328.21
Worry too long after embarrassment 1.99 3 0 0.0 0.00 1.0e+00 ERI1 MAPT PPA2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.93 1 1 3.0 0.00 1.0e+00 U91328.19
Wheeze or whistling in the chest in last year 4.03 5 3 9.1 -0.99 1.3e-03 ADAM19 ARFRP1 PGAP3 STX1B UBA7
Age at first live birth 1.87 1 1 3.0 0.00 1.0e+00 UBA7
Health satisfaction 2.07 1 0 0.0 0.00 1.0e+00 UBA7
Qualifications: College or University degree 2.68 6 3 9.1 0.70 1.2e-01 ARFRP1 EML3 MAPT PPA2 UBA7 VTA1
Mouth/teeth dental problems: Loose teeth 1.70 1 1 3.0 0.00 1.0e+00 RP11-967K21.1
Medication for pain relief, constipation, heartburn 2.61 3 2 6.1 0.00 1.0e+00 MAPT TCP11 U91328.21
Medication: Blood pressure 1.33 1 0 0.0 0.00 1.0e+00 ERI1
Whole body fat mass 2.83 10 7 21.2 -0.82 3.8e-03 ARFRP1 ERI1 NOB1 PYGB RP11-361D14.2 STX1B TCP11 TRIM38 U91328.19 UBA7
Leg fat mass (right) 2.93 9 9 27.3 -0.96 2.7e-05 ARFRP1 ERI1 NOB1 PYGB STX1B TCP11 TRIM38 U91328.19 UBA7
Arm predicted mass (right) 2.70 9 7 21.2 -0.01 9.9e-01 CCDC91 CNKSR1 PPA2 RIN3 RP11-361D14.2 RP11-967K21.1 STX1B U91328.19 UBA7
Pulse rate, automated reading 1.86 4 2 6.1 -0.99 9.0e-03 CNKSR1 EML3 PCGF2 RP11-382A20.2
Alcohol intake frequency. 1.78 2 1 3.0 0.00 1.0e+00 MAPT PPA2
Comparative height size at age 10 2.15 9 5 15.2 0.17 6.6e-01 CCDC91 CEP63 CFDP1 CNKSR1 MAPT MICAL3 PPA2 RP11-361D14.2 U91328.21
Number of full sisters 1.26 1 0 0.0 0.00 1.0e+00 STX1B
Suffer from 'nerves' 1.77 1 0 0.0 0.00 1.0e+00 MAPT
Overall health rating 2.69 4 2 6.1 -0.96 3.9e-02 ERI1 SEC24C STX1B UBA7
Age at last live birth 1.56 1 1 3.0 0.00 1.0e+00 UBA7
Supplements: Vitamin C 1.73 1 0 0.0 0.00 1.0e+00 U91328.19
Knee pain experienced in last month 1.91 1 0 0.0 0.00 1.0e+00 STX1B
Hypertension (Self-reported) 1.73 3 2 6.1 0.00 1.0e+00 CFDP1 ERI1 STX1B
Smoking status: Previous 1.62 1 0 0.0 0.00 1.0e+00 PSMA4
Forced expiratory volume in 1-second (FEV1), predicted 2.16 2 1 3.0 0.00 1.0e+00 CCDC91 RP11-361D14.2
Whole body fat-free mass 2.57 7 7 21.2 0.26 5.8e-01 CNKSR1 PPA2 RIN3 RP11-361D14.2 STX1B U91328.19 UBA7
Leg fat-free mass (right) 2.40 8 6 18.2 0.12 7.8e-01 CNKSR1 ERI1 PPA2 RIN3 RP11-361D14.2 STX1B U91328.19 UBA7
Arm fat percentage (left) 2.91 11 7 21.2 -0.66 2.6e-02 ARFRP1 CCDC91 ERI1 NOB1 PYGB RP11-967K21.1 STX1B TCP11 TRIM38 U91328.19 UBA7
Handedness (chirality/laterality): Left-handed 1.41 1 0 0.0 0.00 1.0e+00 MAPT
Mood swings 2.52 2 2 6.1 0.00 1.0e+00 MAPT UBA7
Long-standing illness, disability or infirmity 2.11 1 0 0.0 0.00 1.0e+00 NOB1
Diabetes diagnosed by doctor 1.97 1 0 0.0 0.00 1.0e+00 NOB1
Mouth/teeth dental problems: Mouth ulcers 1.53 1 1 3.0 0.00 1.0e+00 MAPT
Asthma (self-reported) 4.59 4 2 6.1 -0.97 3.2e-02 ADAM19 PGAP3 TRIM38 U91328.21
Smoking status: Current 2.19 1 1 3.0 0.00 1.0e+00 ARFRP1
Whole body water mass 2.56 7 7 21.2 0.25 5.8e-01 CNKSR1 PPA2 RIN3 RP11-361D14.2 STX1B U91328.19 UBA7
Leg predicted mass (right) 2.39 8 6 18.2 0.12 7.8e-01 CNKSR1 ERI1 PPA2 RIN3 RP11-361D14.2 STX1B U91328.19 UBA7
Arm fat mass (left) 2.72 9 7 21.2 -0.97 1.8e-05 ARFRP1 ERI1 NOB1 PYGB STX1B TCP11 TRIM38 U91328.19 UBA7
Number of self-reported non-cancer illnesses 1.73 1 0 0.0 0.00 1.0e+00 TCP11
Miserableness 1.99 3 1 3.0 0.00 1.0e+00 ERI1 MAPT UBA7
Guilty feelings 1.87 2 1 3.0 0.00 1.0e+00 MAPT UBA7
Financial situation satisfaction 1.36 1 0 0.0 0.00 1.0e+00 UBA7
Medication: Blood pressure 1.93 1 0 0.0 0.00 1.0e+00 ERI1
High cholesterol (Self-reported) 1.66 1 0 0.0 0.00 1.0e+00 STX1B
Medication: Bendroflumethiazide 1.90 1 0 0.0 0.00 1.0e+00 ERI1
Medication: Paracetamol 2.63 3 1 3.0 0.00 1.0e+00 MAPT U91328.21 UBA7
Ever smoked 1.64 2 0 0.0 0.00 1.0e+00 PGAP3 PSMA4
Basal metabolic rate 2.56 8 7 21.2 0.09 8.4e-01 CNKSR1 ERI1 PPA2 RIN3 RP11-361D14.2 STX1B U91328.19 UBA7
Leg fat percentage (left) 3.00 10 8 24.2 -0.98 4.4e-07 ARFRP1 ERI1 NOB1 PYGB RIN3 STX1B TCP11 TRIM38 U91328.19 UBA7
Arm fat-free mass (left) 2.70 8 6 18.2 0.10 8.1e-01 CNKSR1 PPA2 RIN3 RP11-361D14.2 RP11-967K21.1 STX1B U91328.19 UBA7
Number of operations (self-reported) 1.93 2 1 3.0 0.00 1.0e+00 PPA2 UBA7
Average weekly beer plus cider intake 1.72 2 0 0.0 0.00 1.0e+00 ERI1 UBA7
Irritability 2.61 3 1 3.0 0.00 1.0e+00 ERI1 MAPT STX1B
Risk taking 1.93 1 0 0.0 0.00 1.0e+00 PSMA4
Ever had prostate specific antigen (PSA) test 1.69 1 0 0.0 0.00 1.0e+00 U91328.21
Diastolic blood pressure, automated reading 2.68 8 3 9.1 0.17 6.8e-01 ARFRP1 CEP63 ERI1 JAG1 MICAL3 PDE12 STX1B U91328.21
Ever depressed for a whole week 1.50 1 0 0.0 0.00 1.0e+00 UBA7
Vascular/heart problems diagnosed by doctor 1.60 3 2 6.1 0.00 1.0e+00 CFDP1 ERI1 STX1B
Cholesterol lowering medication 1.48 1 0 0.0 0.00 1.0e+00 STX1B
Medication: Omeprazole (e.g. Zanprol) 2.06 1 0 0.0 0.00 1.0e+00 ARFRP1
Pain experienced in last month 2.22 3 0 0.0 0.00 1.0e+00 MAPT STX1B UBA7
Pack years of smoking 6.34 1 1 3.0 0.00 1.0e+00 PSMA4
Impedance of whole body 2.38 9 6 18.2 0.05 9.0e-01 CCDC91 EML3 ERI1 MAPT PPA2 RIN3 RP11-382A20.2 STX1B UBA7
Leg fat mass (left) 2.96 9 9 27.3 -0.96 2.9e-05 ARFRP1 ERI1 NOB1 PYGB STX1B TCP11 TRIM38 U91328.19 UBA7
Arm predicted mass (left) 2.70 8 5 15.2 0.09 8.4e-01 CNKSR1 PPA2 RIN3 RP11-361D14.2 RP11-967K21.1 STX1B U91328.19 UBA7

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 20 0.573 2.09
GTEx Adipose Visceral Omentum 11 0.540 2.30
GTEx Adrenal Gland 13 0.892 2.19
GTEx Artery Aorta 22 0.739 2.29
GTEx Artery Coronary 13 1.099 2.45
GTEx Artery Tibial 14 0.372 2.11
GTEx Brain Caudate basal ganglia 5 0.543 2.23
GTEx Brain Cerebellar Hemisphere 13 0.873 2.23
GTEx Brain Cerebellum 11 0.555 2.12
GTEx Brain Cortex 8 0.773 2.27
GTEx Brain Frontal Cortex BA9 7 0.758 2.26
GTEx Brain Hippocampus 4 0.763 2.20
GTEx Brain Hypothalamus 5 0.847 2.32
GTEx Brain Nucleus accumbens basal ganglia 8 0.925 2.30
GTEx Brain Putamen basal ganglia 5 0.801 2.20
GTEx Breast Mammary Tissue 13 0.659 2.32
GTEx Breast Mammary Tissue (Male) 10 0.838 2.31
GTEx Breast Mammary Tissue (Female) 9 0.547 2.20
GTEx Cells EBV-transformed lymphocytes 13 0.914 2.34
GTEx Cells Transformed fibroblasts 23 0.548 2.22
GTEx Colon Sigmoid 12 0.821 2.36
GTEx Colon Transverse 16 0.775 2.26
GTEx Esophagus Gastroesophageal Junction 13 0.900 2.39
GTEx Esophagus Mucosa 22 0.663 2.24
GTEx Esophagus Muscularis 20 0.619 2.29
GTEx Heart Atrial Appendage 15 0.950 2.52
GTEx Heart Left Ventricle 13 0.850 2.35
GTEx Liver 9 1.255 2.44
GTEx Lung 17 0.592 2.21
GTEx Muscle Skeletal 16 0.554 2.19
GTEx Nerve Tibial 19 0.440 2.12
GTEx Ovary 14 1.542 2.76
GTEx Pancreas 11 0.674 2.15
GTEx Pituitary 12 1.076 2.42
GTEx Prostate 7 0.838 2.43
GTEx Skin Not Sun Exposed Suprapubic 23 0.935 2.24
GTEx Skin Sun Exposed Lower leg 25 0.687 2.27
GTEx Small Intestine Terminal Ileum 5 1.085 2.61
GTEx Spleen 10 0.709 2.29
GTEx Stomach 10 0.688 2.34
GTEx Testis 17 0.539 2.16
GTEx Thyroid 29 0.725 2.22
GTEx Uterus 8 1.411 2.69
GTEx Vagina 5 0.787 2.58
GTEx Whole Blood 12 0.602 2.12
METSIM Adipose 9 0.195 1.92
NTR Blood 11 0.458 1.93
ROSMAP Brain Pre-frontal Cortex 10 0.228 1.93
YFS Blood 19 0.411 1.85
CommonMind Brain Pre-frontal Cortex 18 0.335 1.89
TCGA Breast Tumor 8 1.043 2.27
TCGA Breast Normal 11 0.261 1.75
TCGA Ovarian Tumor 12 0.411 1.97
TCGA Prostate Tumor 16 0.463 2.00