Hub : Traits :

Ulcerative Colitis (UC)

454 significantly associated models · 136 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 1781220 3261925 6 1 1.1e-10 2.1e-11 3.3e-02 90 MMEL1
2 1 7314655 8776719 2 1 9.4e-10 3.4e-11 8.3e-03 84 PARK7
3 1 19227762 21114833 3 6 1.9e-31 3.0e-42 9.8e-01 100 C1orf151 OTUD3 PLA2G5
4 1 154473660 155887772 2 1 2.4e-07 1.7e-07 1.0e+00 100 THBS3
5 1 160851894 162630958 2 1 1.4e-11 2.2e-21 8.2e-13 43 ATF6
6 1 200014178 201528243 1 1 8.8e-08 4.3e-16 5.7e-11 35 CAMSAP2
7 2 60466491 62460013 7 8 4.0e-14 4.3e-23 NaN NaN AC010733.5 AC016747.3 AHSA2 KIAA1841 PEX13 RP11-493E12.2
8 2 199443880 201021954 1 1 1.4e-12 9.8e-13 1.0e+00 100 SATB2
9 2 240827284 242265313 2 2 3.7e-09 4.0e-13 6.2e-04 78 CAPN10 GPR35
10 3 47884239 50932324 34 2 8.8e-20 2.2e-21 1.0e+00 100 FAM212A PRKAR2A
11 4 74173715 75555721 1 1 1.8e-07 2.2e-07 1.0e+00 100 CXCL5
12 5 12225 1390349 5 1 4.8e-11 3.1e-09 1.7e-01 95 EXOC3
13 5 149390148 150838118 1 1 4.2e-09 1.7e-08 7.3e-07 23 DCTN4
14 5 176043333 177426530 2 1 2.2e-08 4.5e-08 5.3e-01 99 RGS14
15 6 110883139 112621834 3 2 7.6e-09 4.5e-11 9.3e-03 84 C6orf3 KIAA1919
16 7 2032803 3581391 2 1 2.6e-10 3.9e-11 4.9e-02 91 AMZ1
17 7 72674074 73952169 1 1 2.9e-07 3.9e-07 4.0e-01 97 WBSCR27
18 7 106847492 108340749 3 1 6.0e-20 4.1e-21 3.6e-04 86 DLD
19 7 127878155 129393341 2 1 2.1e-10 3.2e-10 1.0e+00 100 IRF5
20 9 4287179 6472714 4 2 1.2e-13 6.8e-17 4.1e-03 88 CD274 IGHEP2
21 9 116849447 118266112 1 1 1.0e-11 5.9e-15 4.7e-05 73 TNFSF15
22 9 138525778 140142299 8 3 4.9e-16 1.4e-16 1.0e+00 100 CARD9 RP11-611D20.2
23 11 75678647 77069746 1 1 9.9e-08 5.3e-14 4.0e-08 47 LRRC32
24 12 67971319 69424500 1 1 4.5e-08 1.3e-31 1.2e-25 20 MDM1
25 15 41006523 42468786 1 1 2.1e-07 2.2e-07 1.0e+00 100 RTF1
26 16 23149956 24929475 1 1 4.2e-08 1.8e-08 6.8e-02 90 PRKCB
27 16 27691641 29595483 8 1 5.2e-08 4.2e-07 3.2e-01 96 SULT1A1
28 16 29790709 31224521 1 1 2.4e-07 6.9e-07 1.2e-01 90 ITGAL
29 16 67872251 69294770 1 1 1.5e-08 3.8e-08 1.0e+00 100 ZFP90
30 17 37083464 39510218 14 2 3.9e-17 7.2e-18 4.8e-02 95 KRT222 RAPGEFL1
31 17 39863901 41538783 5 2 1.0e-09 2.0e-11 4.3e-01 99 HSD17B1P1 PTRF
32 20 61576647 62912463 7 2 1.3e-12 3.0e-11 5.8e-01 99 RGS19 STMN3
33 22 34997079 36433816 1 1 2.5e-07 4.5e-07 1.0e+00 100 TOM1
34 22 39064209 40479448 1 1 1.2e-09 3.1e-10 1.5e-05 53 SYNGR1
35 22 49656585 51055900 1 1 3.1e-09 1.5e-10 1.0e+00 100 PIM3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 9.55 21 15 45.5 0.98 6.6e-16 AC010733.5 AHSA2 ATF6 CAMSAP2 CARD9 DCTN4 FAM212A IGHEP2 KIAA1841 LRRC32 PARK7 PEX13 PTRF RAPGEFL1 RGS14 RP11-611D20.2 STMN3 SULT1A1 SYNGR1 THBS3 TNFSF15
Irritable Bowel Disease (IBD) 18.83 48 32 97.0 0.97 8.4e-32 AC010733.5 AC016747.3 AHSA2 AMZ1 ATF6 C1orf151 C6orf3 CAMSAP2 CAPN10 CARD9 CD274 DCTN4 DLD EXOC3 FAM212A GPR35 HSD17B1P1 IGHEP2 IRF5 ITGAL KIAA1841 KIAA1919 KRT222 LRRC32 MDM1 MMEL1 OTUD3 PARK7 PEX13 PIM3 PLA2G5 PRKAR2A PRKCB PTRF RAPGEFL1 RGS14 RGS19 RP11-493E12.2 RP11-611D20.2 SATB2 STMN3 SULT1A1 SYNGR1 THBS3 TNFSF15 TOM1 WBSCR27 ZFP90
Reaction Time 1.13 1 0 0.0 0.00 1.0e+00 EXOC3
Verbal and Numeric Reasoning (VNR) 1.50 2 2 6.1 0.00 1.0e+00 FAM212A SULT1A1
Breast Cancer 1.34 5 0 0.0 0.33 5.8e-01 FAM212A HSD17B1P1 PARK7 RGS19 THBS3
Prostate Cancer 1.51 1 0 0.0 0.00 1.0e+00 FAM212A
Age at First Birth 2.31 1 1 3.0 0.00 1.0e+00 FAM212A
Body Mass Index (BMI) (2010) 1.54 1 0 0.0 0.00 1.0e+00 SULT1A1
Crohns Disease (2012) 6.75 12 9 27.3 -0.98 1.6e-08 AC010733.5 AHSA2 CARD9 DCTN4 FAM212A IGHEP2 PTRF RAPGEFL1 STMN3 SULT1A1 SYNGR1 TNFSF15
HDL Cholesterol 1.20 1 1 3.0 0.00 1.0e+00 RAPGEFL1
Lupus 3.31 2 1 3.0 0.00 1.0e+00 ATF6 IRF5
Primary Biliary Cirrhosis 3.07 4 3 9.1 -0.27 7.3e-01 IRF5 ITGAL RAPGEFL1 SYNGR1
Rheumatoid Arthritis 2.58 3 1 3.0 0.00 1.0e+00 IRF5 LRRC32 MMEL1
Ulcerative Colitis 16.90 40 16 48.5 -1.00 7.3e-45 AC010733.5 AHSA2 AMZ1 ATF6 C1orf151 C6orf3 CAMSAP2 CAPN10 CARD9 CD274 CXCL5 DCTN4 DLD EXOC3 FAM212A IGHEP2 IRF5 ITGAL KIAA1841 KIAA1919 LRRC32 MDM1 MMEL1 OTUD3 PARK7 PEX13 PIM3 PLA2G5 PRKAR2A PRKCB PTRF RAPGEFL1 RP11-493E12.2 RTF1 SATB2 STMN3 SULT1A1 SYNGR1 TNFSF15 ZFP90
Blood Eosinophil Count 2.72 22 17 51.5 -0.07 7.6e-01 AC016747.3 AHSA2 AMZ1 CAMSAP2 CARD9 CD274 GPR35 HSD17B1P1 IGHEP2 IRF5 ITGAL KIAA1841 KRT222 LRRC32 MMEL1 PEX13 PRKAR2A RGS14 RP11-493E12.2 RTF1 TNFSF15 ZFP90
Blood Platelet Count 1.29 10 9 27.3 0.32 3.6e-01 AMZ1 CAPN10 IGHEP2 IRF5 PARK7 STMN3 SULT1A1 THBS3 TOM1 ZFP90
Blood Red Count 1.21 10 7 21.2 0.01 9.8e-01 C6orf3 EXOC3 IGHEP2 ITGAL KIAA1919 KRT222 RGS14 STMN3 SULT1A1 THBS3
Blood White Count 7.65 16 14 42.4 0.58 9.3e-03 AC010733.5 AC016747.3 AHSA2 AMZ1 ATF6 CARD9 FAM212A ITGAL KIAA1841 PEX13 PTRF RAPGEFL1 RGS14 RP11-493E12.2 STMN3 SULT1A1
Heel T-Score 0.89 8 4 12.1 0.47 2.4e-01 AMZ1 C1orf151 CAMSAP2 FAM212A IRF5 PRKAR2A SATB2 THBS3
BMI 1.41 7 5 15.2 0.37 4.2e-01 FAM212A ITGAL MMEL1 PRKAR2A RTF1 SULT1A1 THBS3
Height 1.74 14 9 27.3 -0.44 1.0e-01 AC016747.3 AMZ1 C6orf3 CARD9 FAM212A HSD17B1P1 IRF5 LRRC32 PARK7 PRKAR2A PTRF RGS14 RTF1 TOM1
Waist Hip Ratio (WHR) 1.43 5 5 15.2 0.18 7.7e-01 DLD HSD17B1P1 PRKAR2A RGS19 TOM1
Systolic Blood Pressure 0.95 4 1 3.0 0.74 2.6e-01 FAM212A IRF5 RGS19 STMN3
Allergy or Eczema 5.11 13 10 30.3 -0.61 1.6e-02 AC010733.5 AHSA2 AMZ1 IGHEP2 KIAA1841 KRT222 LRRC32 PEX13 RAPGEFL1 RGS14 RTF1 STMN3 ZFP90
Cardiovascular Disease 1.91 5 1 3.0 0.73 1.6e-01 AHSA2 KIAA1841 KRT222 RGS19 STMN3
Hypothyroidism (self reported) 2.20 6 1 3.0 -0.32 5.4e-01 AC010733.5 CD274 IRF5 MMEL1 PTRF SULT1A1
Respiratory disease 3.64 4 2 6.1 0.20 8.0e-01 KRT222 LRRC32 RAPGEFL1 RGS14
Type 2 Diabetes (T2D) 1.25 1 0 0.0 0.00 1.0e+00 STMN3
Lung FEV1/FVC ratio 2.42 12 8 24.2 -0.54 4.9e-02 AC010733.5 AC016747.3 AHSA2 AMZ1 EXOC3 KIAA1841 MMEL1 PEX13 RAPGEFL1 RGS14 RP11-493E12.2 RTF1
Lung FVC 1.77 8 5 15.2 0.26 5.4e-01 CARD9 FAM212A ITGAL PARK7 SATB2 STMN3 SULT1A1 THBS3
Neuroticism 1.77 6 0 0.0 -0.62 1.4e-01 AC016747.3 AHSA2 FAM212A KIAA1841 PEX13 SATB2
Chronotype (morning person) 1.58 3 0 0.0 -0.99 1.3e-02 AC010733.5 AHSA2 CARD9
Hair Pigment 0.14 4 3 9.1 0.47 5.3e-01 RGS19 SYNGR1 THBS3 TOM1
Tanning 0.21 3 0 0.0 0.00 1.0e+00 PIM3 THBS3 TOM1
Number of treatments/medications taken 1.45 2 1 3.0 0.00 1.0e+00 FAM212A TNFSF15
Average weekly spirits intake 1.30 1 0 0.0 0.00 1.0e+00 FAM212A
Hearing difficulty/problems: Yes 1.05 1 0 0.0 0.00 1.0e+00 SATB2
Relative age of first facial hair 1.59 3 0 0.0 1.00 4.8e-03 AHSA2 LRRC32 SATB2
Systolic blood pressure, automated reading 1.13 3 1 3.0 0.00 1.0e+00 FAM212A RGS19 STMN3
Angina 1.00 1 0 0.0 0.00 1.0e+00 RGS19
Medication: Co-codamol 1.85 1 0 0.0 0.00 1.0e+00 FAM212A
Diabetes (father) 1.43 1 0 0.0 0.00 1.0e+00 PIM3
Pack years adult smoking proportion 1.61 1 0 0.0 0.00 1.0e+00 PRKAR2A
Impedance of leg (right) 0.65 3 0 0.0 0.00 1.0e+00 ITGAL SULT1A1 THBS3
Leg fat-free mass (left) 1.55 5 3 9.1 0.21 7.3e-01 AMZ1 FAM212A PARK7 SULT1A1 THBS3
Trunk fat percentage 1.68 7 4 12.1 0.10 8.3e-01 AMZ1 EXOC3 FAM212A ITGAL MMEL1 RTF1 SULT1A1
Hand grip strength (right) 1.22 2 0 0.0 0.00 1.0e+00 IRF5 SULT1A1
Current tobacco smoking 1.19 1 1 3.0 0.00 1.0e+00 STMN3
Fed-up feelings 1.74 1 1 3.0 0.00 1.0e+00 FAM212A
Relative age voice broke 0.79 1 0 0.0 0.00 1.0e+00 SATB2
Taking other prescription medications 1.98 2 1 3.0 0.00 1.0e+00 FAM212A RAPGEFL1
Age when periods started (menarche) 1.70 2 1 3.0 0.00 1.0e+00 FAM212A SATB2
Heel bone mineral density (BMD) T-score, automated (left) 0.92 1 0 0.0 0.00 1.0e+00 THBS3
High blood pressure 1.52 5 1 3.0 -0.98 2.8e-03 AHSA2 KIAA1841 PEX13 RGS19 RP11-493E12.2
Hayfever, allergic rhinitis or eczema 4.74 11 7 21.2 0.64 1.7e-02 AC010733.5 AHSA2 IGHEP2 KIAA1841 KRT222 LRRC32 PEX13 RAPGEFL1 RGS14 STMN3 ZFP90
Stomach or abdominal pain in last month 1.29 1 0 0.0 0.00 1.0e+00 CAMSAP2
Medication: Levothyroxine sodium 1.90 2 0 0.0 0.00 1.0e+00 MMEL1 PTRF
Sitting height 1.55 7 3 9.1 0.71 7.2e-02 AMZ1 CARD9 HSD17B1P1 PARK7 PRKAR2A RGS14 TOM1
Body mass index (BMI) 1.42 5 3 9.1 -0.28 6.5e-01 FAM212A ITGAL MMEL1 RTF1 SULT1A1
Impedance of leg (left) 0.65 2 1 3.0 0.00 1.0e+00 SULT1A1 THBS3
Leg predicted mass (left) 1.55 5 3 9.1 0.22 7.3e-01 AMZ1 FAM212A PARK7 SULT1A1 THBS3
Trunk fat mass 1.90 7 3 9.1 0.13 7.9e-01 AMZ1 EXOC3 FAM212A ITGAL MMEL1 RTF1 SULT1A1
Waist circumference 1.58 5 3 9.1 0.42 4.9e-01 AMZ1 EXOC3 FAM212A ITGAL SULT1A1
Past tobacco smoking 1.11 1 0 0.0 0.00 1.0e+00 THBS3
Alcohol usually taken with meals 0.88 1 0 0.0 0.00 1.0e+00 SULT1A1
Nervous feelings 1.38 1 0 0.0 0.00 1.0e+00 SATB2
Forced vital capacity (FVC) 1.31 4 2 6.1 0.60 4.0e-01 AMZ1 FAM212A SATB2 STMN3
Qualifications: None of the above 1.27 2 2 6.1 0.00 1.0e+00 FAM212A SULT1A1
Mouth/teeth dental problems 1.75 2 1 3.0 0.00 1.0e+00 IRF5 THBS3
Allergy 4.95 12 6 18.2 -0.57 3.4e-02 AC010733.5 AHSA2 AMZ1 IGHEP2 KIAA1841 KRT222 LRRC32 PEX13 RAPGEFL1 RGS14 STMN3 ZFP90
Diabetes (self-reported) 1.68 1 0 0.0 0.00 1.0e+00 STMN3
Hayfever/allergic rhinitis (self-reported) 2.06 3 0 0.0 0.00 1.0e+00 KRT222 LRRC32 RAPGEFL1
Medication: Simvastatin 1.14 1 0 0.0 0.00 1.0e+00 RGS19
Fluid intelligence score 1.98 3 2 6.1 0.00 1.0e+00 AHSA2 FAM212A SULT1A1
Neuroticism score 1.70 3 0 0.0 0.00 1.0e+00 AHSA2 KIAA1841 PEX13
Weight 1.84 6 4 12.1 0.15 7.8e-01 AMZ1 FAM212A ITGAL MMEL1 PARK7 SULT1A1
Impedance of arm (right) 0.90 6 1 3.0 0.67 1.5e-01 AMZ1 FAM212A LRRC32 PRKAR2A RAPGEFL1 SATB2
Arm fat percentage (right) 1.52 6 3 9.1 -0.03 9.5e-01 AMZ1 FAM212A ITGAL RTF1 SULT1A1 THBS3
Trunk fat-free mass 1.25 4 3 9.1 0.57 4.3e-01 AMZ1 CARD9 FAM212A PARK7
Hip circumference 1.90 6 4 12.1 0.48 3.3e-01 AMZ1 FAM212A ITGAL PARK7 SULT1A1 TOM1
Alcohol intake versus 10 years previously 1.07 1 1 3.0 0.00 1.0e+00 FAM212A
Father's age at death 1.51 1 0 0.0 0.00 1.0e+00 FAM212A
Worrier / anxious feelings 1.91 2 0 0.0 0.00 1.0e+00 AHSA2 SATB2
Forced expiratory volume in 1-second (FEV1) 1.21 5 1 3.0 0.31 6.1e-01 EXOC3 FAM212A PRKAR2A STMN3 THBS3
Pulse rate 0.81 1 0 0.0 0.00 1.0e+00 PRKAR2A
Qualifications: A levels/AS levels or equivalent 1.71 2 1 3.0 0.00 1.0e+00 FAM212A SULT1A1
Mouth/teeth dental problems: Dentures 1.60 2 1 3.0 0.00 1.0e+00 FAM212A THBS3
Asthma 3.68 3 2 6.1 0.00 1.0e+00 KRT222 LRRC32 RAPGEFL1
Medication: Cholesterol lowering 1.31 1 1 3.0 0.00 1.0e+00 RGS19
Depression (self-reported) 1.45 1 0 0.0 0.00 1.0e+00 WBSCR27
Forced expiratory volume in 1-second (FEV1), Best measure 1.24 4 1 3.0 0.62 3.8e-01 FAM212A PRKAR2A SATB2 STMN3
Impedance of arm (left) 0.99 6 2 6.1 0.69 1.3e-01 AMZ1 FAM212A LRRC32 PRKAR2A RAPGEFL1 SATB2
Arm fat mass (right) 1.73 6 4 12.1 0.02 9.8e-01 AMZ1 FAM212A ITGAL RTF1 SULT1A1 THBS3
Trunk predicted mass 1.22 3 3 9.1 0.00 1.0e+00 AMZ1 CARD9 PARK7
Standing height 1.62 8 4 12.1 0.60 8.7e-02 AMZ1 CARD9 HSD17B1P1 PARK7 PRKAR2A PTRF RTF1 TOM1
Hair/balding pattern: Pattern 4 1.55 3 0 0.0 0.00 1.0e+00 KIAA1919 PEX13 THBS3
Birth weight of first child 0.98 1 0 0.0 0.00 1.0e+00 RGS19
Qualifications: O levels/GCSEs or equivalent 1.33 1 0 0.0 0.00 1.0e+00 FAM212A
Medication: Paracetamol 0.93 1 0 0.0 0.00 1.0e+00 FAM212A
Medication for cholesterol, blood pressure or diabetes 1.90 1 1 3.0 0.00 1.0e+00 RGS19
Gout (self-reported) 2.05 1 0 0.0 0.00 1.0e+00 THBS3
Hypothyroidism/myxoedema (self-reported) 2.15 3 0 0.0 0.00 1.0e+00 CD274 MMEL1 PTRF
Medication: Amlodipine 2.03 2 0 0.0 0.00 1.0e+00 AHSA2 KIAA1841
Medication: Ventolin 100micrograms inhaler 2.18 1 1 3.0 0.00 1.0e+00 RAPGEFL1
Birth weight 1.07 2 1 3.0 0.00 1.0e+00 AMZ1 PIM3
Forced vital capacity (FVC), Best measure 1.35 4 2 6.1 0.62 3.8e-01 AMZ1 FAM212A SATB2 STMN3
Body fat percentage 1.61 7 4 12.1 0.01 9.8e-01 AMZ1 EXOC3 FAM212A ITGAL MMEL1 RTF1 SULT1A1
Leg fat percentage (right) 1.45 4 3 9.1 -0.64 3.6e-01 FAM212A KRT222 RTF1 SULT1A1
Arm fat-free mass (right) 1.27 5 3 9.1 0.42 4.8e-01 AMZ1 CARD9 FAM212A PARK7 SULT1A1
Comparative body size at age 10 1.78 7 1 3.0 -0.42 2.9e-01 AC016747.3 AHSA2 ITGAL KIAA1841 PEX13 RP11-493E12.2 SULT1A1
Wheeze or whistling in the chest in last year 1.97 2 2 6.1 0.00 1.0e+00 FAM212A RAPGEFL1
Age at first live birth 1.60 2 1 3.0 0.00 1.0e+00 CAMSAP2 FAM212A
Qualifications: College or University degree 2.02 5 3 9.1 0.07 9.1e-01 FAM212A ITGAL PRKAR2A STMN3 SULT1A1
Emphysema/chronic bronchitis 1.33 1 0 0.0 0.00 1.0e+00 RAPGEFL1
Angina (self-reported) 0.94 1 0 0.0 0.00 1.0e+00 RGS19
Medication: Allopurinol 1.71 1 0 0.0 0.00 1.0e+00 THBS3
Mean time to correctly identify matches 1.04 1 0 0.0 0.00 1.0e+00 EXOC3
Whole body fat mass 1.86 6 3 9.1 0.01 9.9e-01 AMZ1 FAM212A ITGAL MMEL1 RTF1 SULT1A1
Leg fat mass (right) 1.64 6 3 9.1 -0.12 8.2e-01 AMZ1 FAM212A ITGAL MMEL1 RTF1 SULT1A1
Arm predicted mass (right) 1.33 6 3 9.1 0.38 4.6e-01 AMZ1 CARD9 FAM212A PARK7 SULT1A1 SYNGR1
Pulse rate, automated reading 1.04 2 1 3.0 0.00 1.0e+00 FAM212A PRKAR2A
Alcohol intake frequency. 1.47 2 1 3.0 0.00 1.0e+00 FAM212A SULT1A1
Comparative height size at age 10 1.61 5 3 9.1 0.71 1.1e-01 AC016747.3 AMZ1 CARD9 EXOC3 SULT1A1
Suffer from 'nerves' 1.87 2 2 6.1 0.00 1.0e+00 SATB2 SULT1A1
Overall health rating 1.38 2 1 3.0 0.00 1.0e+00 AMZ1 FAM212A
Chest pain or discomfort 1.41 1 0 0.0 0.00 1.0e+00 RAPGEFL1
Age at last live birth 1.56 1 1 3.0 0.00 1.0e+00 FAM212A
Leg pain on walking 1.25 1 0 0.0 0.00 1.0e+00 FAM212A
Medication: Aspirin 1.19 1 0 0.0 0.00 1.0e+00 RGS19
Hypertension (Self-reported) 1.31 2 1 3.0 0.00 1.0e+00 KRT222 RGS19
Smoking status: Previous 1.31 1 0 0.0 0.00 1.0e+00 THBS3
Forced expiratory volume in 1-second (FEV1), predicted 1.27 1 1 3.0 0.00 1.0e+00 AMZ1
Whole body fat-free mass 1.38 5 3 9.1 0.49 4.0e-01 AMZ1 CARD9 FAM212A PARK7 SULT1A1
Leg fat-free mass (right) 1.49 5 2 6.1 0.23 7.1e-01 AMZ1 FAM212A PARK7 SULT1A1 THBS3
Arm fat percentage (left) 1.52 6 4 12.1 -0.02 9.7e-01 AMZ1 FAM212A ITGAL RTF1 SULT1A1 THBS3
Handedness (chirality/laterality): Left-handed 1.16 1 0 0.0 0.00 1.0e+00 SULT1A1
Mood swings 1.45 1 1 3.0 0.00 1.0e+00 FAM212A
Loneliness, isolation 1.63 1 0 0.0 0.00 1.0e+00 FAM212A
Qualifications: nursing, teaching 1.14 1 0 0.0 0.00 1.0e+00 FAM212A
Mouth/teeth dental problems: Mouth ulcers 2.18 3 1 3.0 0.00 1.0e+00 IRF5 RAPGEFL1 TNFSF15
Medication for cholesterol 1.12 1 0 0.0 0.00 1.0e+00 RGS19
Asthma (self-reported) 3.70 3 2 6.1 0.00 1.0e+00 KRT222 LRRC32 RAPGEFL1
Medication: Aspirin 1.27 1 0 0.0 0.00 1.0e+00 RGS19
Smoking status: Current 1.08 1 0 0.0 0.00 1.0e+00 STMN3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.64 4 2 6.1 -0.48 5.2e-01 AMZ1 ITGAL RAPGEFL1 STMN3
Whole body water mass 1.36 5 3 9.1 0.49 4.0e-01 AMZ1 CARD9 FAM212A PARK7 SULT1A1
Leg predicted mass (right) 1.49 5 2 6.1 0.23 7.1e-01 AMZ1 FAM212A PARK7 SULT1A1 THBS3
Arm fat mass (left) 1.70 7 4 12.1 -0.05 9.1e-01 AMZ1 FAM212A ITGAL MMEL1 RTF1 SULT1A1 THBS3
Number of self-reported non-cancer illnesses 1.55 3 1 3.0 0.00 1.0e+00 RAPGEFL1 RGS19 STMN3
Miserableness 2.04 2 1 3.0 0.00 1.0e+00 FAM212A RAPGEFL1
Financial situation satisfaction 0.94 1 0 0.0 0.00 1.0e+00 FAM212A
Medication: Blood pressure 1.34 1 0 0.0 0.00 1.0e+00 RGS19
High cholesterol (Self-reported) 1.45 1 1 3.0 0.00 1.0e+00 RGS19
Medication: Paracetamol 1.11 2 0 0.0 0.00 1.0e+00 FAM212A PRKAR2A
Medication: Atorvastatin 1.24 1 0 0.0 0.00 1.0e+00 THBS3
Basal metabolic rate 1.50 5 4 12.1 0.44 4.6e-01 AMZ1 CARD9 FAM212A PARK7 SULT1A1
Leg fat percentage (left) 1.51 7 3 9.1 -0.28 5.4e-01 FAM212A ITGAL KRT222 MMEL1 RTF1 STMN3 SULT1A1
Arm fat-free mass (left) 1.36 5 4 12.1 0.42 4.8e-01 AMZ1 CARD9 FAM212A PARK7 SULT1A1
Number of operations (self-reported) 1.48 2 1 3.0 0.00 1.0e+00 AMZ1 PARK7
Diastolic blood pressure, automated reading 1.37 3 2 6.1 0.00 1.0e+00 FAM212A RTF1 STMN3
Vascular/heart problems diagnosed by doctor 1.57 6 1 3.0 0.97 1.5e-03 AHSA2 KIAA1841 PEX13 RGS19 RP11-493E12.2 RTF1
Cholesterol lowering medication 1.77 1 0 0.0 0.00 1.0e+00 RGS19
Medication: Omeprazole (e.g. Zanprol) 1.40 1 0 0.0 0.00 1.0e+00 EXOC3
Pain experienced in last month 1.13 1 0 0.0 0.00 1.0e+00 FAM212A
Impedance of whole body 0.74 3 1 3.0 0.00 1.0e+00 FAM212A PRKAR2A SATB2
Leg fat mass (left) 1.69 6 3 9.1 -0.11 8.3e-01 AMZ1 FAM212A ITGAL MMEL1 RTF1 SULT1A1
Arm predicted mass (left) 1.41 5 3 9.1 0.40 5.0e-01 AMZ1 CARD9 FAM212A PARK7 SULT1A1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 7 0.201 1.90
GTEx Adipose Visceral Omentum 7 0.344 1.96
GTEx Adrenal Gland 5 0.344 1.97
GTEx Artery Aorta 7 0.235 1.87
GTEx Artery Coronary 6 0.508 2.01
GTEx Artery Tibial 15 0.399 1.89
GTEx Brain Caudate basal ganglia 3 0.325 1.91
GTEx Brain Cerebellar Hemisphere 12 0.805 2.02
GTEx Brain Cerebellum 10 0.504 1.92
GTEx Brain Cortex 4 0.386 1.93
GTEx Brain Frontal Cortex BA9 7 0.757 2.05
GTEx Brain Hippocampus 1 0.190 1.82
GTEx Brain Hypothalamus 3 0.508 2.03
GTEx Brain Nucleus accumbens basal ganglia 2 0.231 1.85
GTEx Brain Putamen basal ganglia 2 0.320 1.89
GTEx Breast Mammary Tissue 6 0.305 1.92
GTEx Breast Mammary Tissue (Male) 4 0.336 1.81
GTEx Breast Mammary Tissue (Female) 3 0.183 1.89
GTEx Cells EBV-transformed lymphocytes 5 0.352 2.03
GTEx Cells Transformed fibroblasts 13 0.310 1.88
GTEx Colon Sigmoid 8 0.547 2.03
GTEx Colon Transverse 6 0.291 1.93
GTEx Esophagus Gastroesophageal Junction 5 0.346 2.00
GTEx Esophagus Mucosa 15 0.452 2.01
GTEx Esophagus Muscularis 18 0.557 1.95
GTEx Heart Atrial Appendage 11 0.696 1.99
GTEx Heart Left Ventricle 5 0.326 1.87
GTEx Liver 3 0.420 1.79
GTEx Lung 12 0.418 1.99
GTEx Muscle Skeletal 8 0.277 1.87
GTEx Nerve Tibial 15 0.347 1.90
GTEx Ovary 4 0.440 2.09
GTEx Pancreas 8 0.490 1.99
GTEx Pituitary 4 0.359 1.91
GTEx Prostate 3 0.361 2.00
GTEx Skin Not Sun Exposed Suprapubic 8 0.326 1.96
GTEx Skin Sun Exposed Lower leg 19 0.523 2.03
GTEx Small Intestine Terminal Ileum 1 0.218 1.82
GTEx Spleen 12 0.851 2.15
GTEx Stomach 9 0.619 1.99
GTEx Testis 12 0.380 1.88
GTEx Thyroid 14 0.351 1.94
GTEx Uterus 4 0.705 2.03
GTEx Vagina 1 0.157 1.99
GTEx Whole Blood 15 0.753 2.19
METSIM Adipose 15 0.326 1.86
NTR Blood 14 0.582 2.00
ROSMAP Brain Pre-frontal Cortex 17 0.387 1.87
YFS Blood 24 0.520 1.90
CommonMind Brain Pre-frontal Cortex 14 0.260 1.77
TCGA Breast Tumor 3 0.392 1.70
TCGA Breast Normal 7 0.166 1.62
TCGA Ovarian Tumor 4 0.137 1.64
TCGA Prostate Tumor 14 0.405 1.81