Hub : Traits :

Medication: Bendroflumethiazide

51 significantly associated models · 35 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 26428864 27820430 1 1 3.0e-07 1.4e-06 6.9e-03 69 PIGV
2 1 112312154 113907148 2 1 1.6e-08 9.4e-10 7.3e-08 23 WNT2B
3 3 26720690 28211713 1 1 1.7e-07 2.1e-08 4.1e-02 87 SLC4A7
4 5 130830617 132304222 2 1 3.1e-08 1.6e-07 1.0e+00 100 PDLIM4
5 8 8092025 13120332 13 2 6.7e-09 1.2e-08 3.6e-02 86 ERI1 NEIL2
6 8 30012514 31433801 1 1 3.2e-07 1.6e-07 1.1e-01 90 TEX15
7 11 1213806 2640824 2 1 1.9e-12 3.6e-16 4.1e-05 75 TNNT3
8 11 46570859 47977454 2 1 6.1e-09 1.4e-06 5.6e-01 98 ACP2
9 11 99859184 101559718 2 1 1.6e-07 8.5e-08 1.0e+00 100 ARHGAP42
10 15 74042497 75930199 4 1 2.7e-08 7.7e-08 1.0e+00 100 ULK3
11 15 90730363 92135418 1 1 2.7e-07 1.8e-07 1.7e-01 93 FES
12 16 3969463 5433992 1 1 9.8e-08 1.6e-05 8.8e-02 84 MGRN1
13 16 29412503 31102321 3 2 1.0e-09 5.2e-07 4.6e-01 98 ALDOA ZNF48

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.46 1 0 0.0 0.00 1.0e+00 ZNF48
Crohns Disease (2017) 3.04 1 1 3.0 0.00 1.0e+00 PDLIM4
Irritable Bowel Disease (IBD) 2.40 2 1 3.0 0.00 1.0e+00 FES PDLIM4
Major Depression (MDD) 1.87 1 0 0.0 0.00 1.0e+00 FES
Verbal and Numeric Reasoning (VNR) 1.34 1 0 0.0 0.00 1.0e+00 TEX15
Breast Cancer 9.08 5 2 6.1 -0.39 5.2e-01 FES PDLIM4 SLC4A7 TNNT3 ULK3
Body Mass Index (BMI) (2010) 2.56 1 0 0.0 0.00 1.0e+00 ALDOA
Coronary Artery Disease (CAD) 1.60 1 0 0.0 0.00 1.0e+00 FES
Crohns Disease (2012) 2.24 1 1 3.0 0.00 1.0e+00 PDLIM4
Mean Putamen Volume 1.93 1 0 0.0 0.00 1.0e+00 NEIL2
Fasting Glucose 3.72 1 1 3.0 0.00 1.0e+00 ACP2
HDL Cholesterol 3.34 2 1 3.0 0.00 1.0e+00 ACP2 PIGV
Lupus 2.60 1 0 0.0 0.00 1.0e+00 ERI1
Neuroticism 3.82 2 2 6.1 0.00 1.0e+00 ERI1 NEIL2
Schizophrenia 3.27 3 1 3.0 0.00 1.0e+00 ALDOA ERI1 FES
Triglycerides 3.16 3 0 0.0 0.00 1.0e+00 ERI1 NEIL2 PDLIM4
Blood Eosinophil Count 9.95 4 3 9.1 -0.33 6.7e-01 ALDOA PDLIM4 PIGV ZNF48
Blood Platelet Count 2.74 8 4 12.1 -0.31 4.5e-01 ARHGAP42 MGRN1 PDLIM4 PIGV SLC4A7 ULK3 WNT2B ZNF48
Blood Red Count 2.80 5 2 6.1 0.29 6.4e-01 ALDOA FES MGRN1 ULK3 ZNF48
Blood White Count 4.53 7 3 9.1 -0.31 5.0e-01 ALDOA ARHGAP42 FES MGRN1 PDLIM4 TEX15 ZNF48
Heel T-Score 1.74 5 4 12.1 0.67 2.1e-01 ACP2 ALDOA ARHGAP42 SLC4A7 ZNF48
BMI 3.75 4 3 9.1 -0.72 2.8e-01 ALDOA TEX15 ULK3 ZNF48
Height 3.13 11 7 21.2 0.30 3.7e-01 ACP2 ALDOA ARHGAP42 FES MGRN1 PDLIM4 PIGV SLC4A7 TNNT3 WNT2B ZNF48
Waist Hip Ratio (WHR) 1.05 2 0 0.0 0.00 1.0e+00 TNNT3 ULK3
Systolic Blood Pressure 19.91 9 9 27.3 -0.94 1.5e-04 ACP2 ARHGAP42 FES MGRN1 PIGV SLC4A7 TNNT3 ULK3 WNT2B
Smoking Status 1.11 1 0 0.0 0.00 1.0e+00 FES
Allergy or Eczema 2.45 3 1 3.0 0.00 1.0e+00 FES PDLIM4 ULK3
Cardiovascular Disease 15.53 13 9 27.3 -0.93 3.6e-06 ACP2 ALDOA ARHGAP42 FES MGRN1 PDLIM4 PIGV SLC4A7 TEX15 TNNT3 ULK3 WNT2B ZNF48
Respiratory disease 3.96 2 1 3.0 0.00 1.0e+00 FES PDLIM4
Type 2 Diabetes (T2D) 1.43 1 0 0.0 0.00 1.0e+00 ALDOA
Lung FEV1/FVC ratio 1.53 4 2 6.1 0.97 2.6e-02 ALDOA ARHGAP42 PDLIM4 ZNF48
Lung FVC 1.16 2 2 6.1 0.00 1.0e+00 PDLIM4 ZNF48
Neuroticism 1.17 1 0 0.0 0.00 1.0e+00 ACP2
Chronotype (morning person) 1.71 2 0 0.0 0.00 1.0e+00 ACP2 ALDOA
Hair Pigment 0.25 3 2 6.1 0.00 1.0e+00 ACP2 ARHGAP42 FES
Tanning 0.27 2 0 0.0 0.00 1.0e+00 TEX15 ULK3
Hand grip strength (left) 4.21 6 2 6.1 -0.31 5.5e-01 ALDOA FES MGRN1 PDLIM4 WNT2B ZNF48
Number of treatments/medications taken 5.05 6 0 0.0 0.99 2.7e-04 ARHGAP42 FES MGRN1 PDLIM4 SLC4A7 ZNF48
Sensitivity / hurt feelings 3.24 2 1 3.0 0.00 1.0e+00 ERI1 FES
Frequency of depressed mood in last 2 weeks 1.65 1 0 0.0 0.00 1.0e+00 NEIL2
Systolic blood pressure, automated reading 14.14 11 7 21.2 0.92 7.2e-05 ACP2 ARHGAP42 ERI1 FES MGRN1 NEIL2 PIGV SLC4A7 TNNT3 ULK3 WNT2B
Angina 4.52 2 1 3.0 0.00 1.0e+00 ARHGAP42 FES
Diabetes (father) 2.06 1 0 0.0 0.00 1.0e+00 ALDOA
Diabetes (mother) 2.00 1 0 0.0 0.00 1.0e+00 ZNF48
Impedance of leg (right) 5.11 6 5 15.2 -0.76 8.0e-02 ALDOA ARHGAP42 ERI1 FES NEIL2 ZNF48
Leg fat-free mass (left) 5.29 7 3 9.1 0.31 5.0e-01 ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 ZNF48
Trunk fat percentage 2.59 5 3 9.1 0.35 5.7e-01 ALDOA SLC4A7 TEX15 TNNT3 ZNF48
Hand grip strength (right) 3.71 4 1 3.0 -0.17 8.3e-01 ALDOA PDLIM4 WNT2B ZNF48
Current tobacco smoking 2.35 1 0 0.0 0.00 1.0e+00 ERI1
Fed-up feelings 2.92 5 0 0.0 0.48 4.1e-01 ACP2 ALDOA ERI1 NEIL2 TEX15
Frequency of unenthusiasm / disinterest in last 2 weeks 1.43 1 0 0.0 0.00 1.0e+00 TEX15
Age when periods started (menarche) 1.95 2 0 0.0 0.00 1.0e+00 ALDOA TNNT3
Heel bone mineral density (BMD) T-score, automated (left) 4.23 4 2 6.1 0.45 5.5e-01 ACP2 ARHGAP42 ERI1 NEIL2
High blood pressure 21.17 15 11 33.3 0.94 2.8e-07 ACP2 ALDOA ARHGAP42 ERI1 FES MGRN1 NEIL2 PDLIM4 PIGV SLC4A7 TEX15 TNNT3 ULK3 WNT2B ZNF48
Hayfever, allergic rhinitis or eczema 2.73 3 1 3.0 0.00 1.0e+00 FES PDLIM4 ULK3
Supplements: Glucosamine 2.02 1 0 0.0 0.00 1.0e+00 ULK3
Medication: Atenolol 7.98 7 1 3.0 0.97 4.2e-04 ARHGAP42 FES SLC4A7 TEX15 TNNT3 ULK3 WNT2B
Medication: Levothyroxine sodium 1.68 1 0 0.0 0.00 1.0e+00 ERI1
Sitting height 1.71 3 1 3.0 0.00 1.0e+00 NEIL2 PDLIM4 SLC4A7
High blood pressure (mother) 10.04 6 2 6.1 0.97 1.5e-03 ACP2 ALDOA ARHGAP42 FES SLC4A7 TNNT3
Body mass index (BMI) 5.00 5 4 12.1 0.97 6.9e-03 ALDOA ERI1 NEIL2 TEX15 ZNF48
Impedance of leg (left) 4.93 7 5 15.2 -0.75 5.2e-02 ALDOA ARHGAP42 ERI1 FES NEIL2 WNT2B ZNF48
Leg predicted mass (left) 5.30 7 3 9.1 0.32 4.9e-01 ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 ZNF48
Trunk fat mass 3.53 3 3 9.1 0.00 1.0e+00 ALDOA TEX15 ZNF48
Waist circumference 5.21 4 3 9.1 0.71 2.9e-01 ALDOA TEX15 ULK3 ZNF48
Number of incorrect matches in round 3.40 2 1 3.0 0.00 1.0e+00 ALDOA FES
Alcohol usually taken with meals 1.97 1 0 0.0 0.00 1.0e+00 FES
Nervous feelings 4.36 5 1 3.0 -0.68 2.1e-01 ACP2 ALDOA ERI1 NEIL2 ZNF48
Frequency of tenseness / restlessness in last 2 weeks 1.96 1 0 0.0 0.00 1.0e+00 ZNF48
Hearing difficulty/problems with background noise 2.34 1 0 0.0 0.00 1.0e+00 ULK3
Forced vital capacity (FVC) 1.74 4 0 0.0 -0.67 3.3e-01 ACP2 ALDOA ARHGAP42 WNT2B
Heel bone mineral density (BMD) T-score, automated (right) 4.29 4 2 6.1 0.25 7.5e-01 ACP2 ARHGAP42 ERI1 NEIL2
Qualifications: None of the above 2.05 1 1 3.0 0.00 1.0e+00 TEX15
Mouth/teeth dental problems 2.36 1 0 0.0 0.00 1.0e+00 ERI1
Heart attack 2.58 1 1 3.0 0.00 1.0e+00 FES
Allergy 3.04 2 1 3.0 0.00 1.0e+00 FES PDLIM4
Hayfever/allergic rhinitis (self-reported) 1.66 1 0 0.0 0.00 1.0e+00 ERI1
Medication: Ramipril 7.79 5 1 3.0 0.99 2.2e-03 ACP2 ARHGAP42 FES TNNT3 ULK3
Medication: Simvastatin 4.60 4 1 3.0 0.98 1.9e-02 ARHGAP42 FES PIGV TEX15
Fluid intelligence score 1.21 1 0 0.0 0.00 1.0e+00 TEX15
Illnesses of siblings 4.57 2 0 0.0 0.00 1.0e+00 ARHGAP42 FES
Neuroticism score 3.76 3 2 6.1 0.00 1.0e+00 ACP2 ERI1 NEIL2
Weight 5.24 6 2 6.1 0.65 1.6e-01 ALDOA ERI1 NEIL2 PDLIM4 TEX15 ZNF48
Impedance of arm (right) 4.15 6 4 12.1 -0.93 6.6e-03 ALDOA ERI1 NEIL2 SLC4A7 TNNT3 ZNF48
Arm fat percentage (right) 3.60 5 3 9.1 0.85 7.1e-02 ALDOA ERI1 SLC4A7 TEX15 ZNF48
Trunk fat-free mass 4.75 7 3 9.1 0.24 6.0e-01 ACP2 ALDOA ARHGAP42 NEIL2 PDLIM4 SLC4A7 ZNF48
Hip circumference 4.22 5 2 6.1 0.91 3.0e-02 ALDOA ERI1 NEIL2 TEX15 ZNF48
Alcohol intake versus 10 years previously 1.74 1 0 0.0 0.00 1.0e+00 ALDOA
Father's age at death 4.32 4 1 3.0 -0.99 1.3e-02 ERI1 FES PDLIM4 ULK3
Worrier / anxious feelings 4.93 2 2 6.1 0.00 1.0e+00 ERI1 NEIL2
Forced expiratory volume in 1-second (FEV1) 2.18 4 0 0.0 -0.99 1.1e-02 ARHGAP42 ERI1 PDLIM4 WNT2B
Qualifications: A levels/AS levels or equivalent 1.74 2 0 0.0 0.00 1.0e+00 TEX15 ULK3
Mouth/teeth dental problems: Dentures 2.49 1 0 0.0 0.00 1.0e+00 ERI1
Asthma 4.26 2 1 3.0 0.00 1.0e+00 FES PDLIM4
Medication: Ibuprofen (e.g. Nurofen) 1.67 1 0 0.0 0.00 1.0e+00 ULK3
Medication: Cholesterol lowering 4.99 3 1 3.0 0.00 1.0e+00 ARHGAP42 FES PIGV
Illnesses of mother 5.88 4 1 3.0 -0.96 4.4e-02 ARHGAP42 FES SLC4A7 TNNT3
Forced expiratory volume in 1-second (FEV1), Best measure 2.15 5 0 0.0 -1.00 2.1e-04 ACP2 ARHGAP42 ERI1 PDLIM4 ZNF48
Pulse wave Arterial Stiffness index 2.11 1 0 0.0 0.00 1.0e+00 FES
Impedance of arm (left) 4.23 6 4 12.1 -0.94 5.9e-03 ALDOA ERI1 NEIL2 SLC4A7 TNNT3 ZNF48
Arm fat mass (right) 4.77 5 3 9.1 0.95 1.5e-02 ALDOA ERI1 NEIL2 TEX15 ZNF48
Trunk predicted mass 4.73 7 3 9.1 0.24 6.0e-01 ACP2 ALDOA ARHGAP42 NEIL2 PDLIM4 SLC4A7 ZNF48
Standing height 3.06 7 3 9.1 -0.41 3.6e-01 ACP2 ALDOA ERI1 MGRN1 PDLIM4 SLC4A7 WNT2B
Breastfed as a baby 2.40 2 0 0.0 0.00 1.0e+00 FES PIGV
Tense / 'highly strung' 3.46 3 1 3.0 0.00 1.0e+00 ALDOA ERI1 NEIL2
Hair/balding pattern: Pattern 4 0.92 1 0 0.0 0.00 1.0e+00 FES
Birth weight of first child 5.12 3 1 3.0 0.00 1.0e+00 FES NEIL2 PDLIM4
Peak expiratory flow (PEF) 2.01 3 0 0.0 0.00 1.0e+00 ERI1 PDLIM4 ULK3
Pulse wave reflection index 1.83 1 0 0.0 0.00 1.0e+00 NEIL2
Qualifications: O levels/GCSEs or equivalent 2.39 1 0 0.0 0.00 1.0e+00 ULK3
Mouth/teeth dental problems: Bleeding gums 1.72 1 0 0.0 0.00 1.0e+00 ACP2
Medication: Paracetamol 1.95 1 0 0.0 0.00 1.0e+00 TEX15
Headache pain in last month 1.79 2 0 0.0 0.00 1.0e+00 ERI1 FES
Medication for cholesterol, blood pressure or diabetes 11.09 8 3 9.1 -0.95 2.4e-04 ACP2 ARHGAP42 FES PIGV SLC4A7 TEX15 ULK3 WNT2B
Hypothyroidism/myxoedema (self-reported) 2.52 2 1 3.0 0.00 1.0e+00 ERI1 NEIL2
Medication: Amlodipine 10.56 7 4 12.1 0.99 4.6e-05 ACP2 ARHGAP42 FES MGRN1 SLC4A7 TNNT3 WNT2B
Medication: Ventolin 100micrograms inhaler 1.72 1 0 0.0 0.00 1.0e+00 PDLIM4
Birth weight 2.40 2 1 3.0 0.00 1.0e+00 FES PDLIM4
High blood pressure (siblings) 7.30 5 1 3.0 0.98 2.3e-03 ACP2 ARHGAP42 FES SLC4A7 TNNT3
Forced vital capacity (FVC), Best measure 1.45 2 0 0.0 0.00 1.0e+00 ACP2 WNT2B
Body fat percentage 3.01 4 3 9.1 0.79 2.1e-01 ALDOA SLC4A7 TEX15 ZNF48
Leg fat percentage (right) 3.00 4 3 9.1 0.97 2.8e-02 ALDOA PDLIM4 TEX15 ZNF48
Arm fat-free mass (right) 4.91 7 3 9.1 0.43 3.4e-01 ALDOA ARHGAP42 ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48
Comparative body size at age 10 4.25 4 4 12.1 0.99 5.0e-03 ALDOA ERI1 NEIL2 ZNF48
Worry too long after embarrassment 2.60 2 1 3.0 0.00 1.0e+00 ERI1 WNT2B
Seen a psychiatrist for nerves, anxiety, tension or depression 1.49 1 0 0.0 0.00 1.0e+00 ALDOA
Wheeze or whistling in the chest in last year 2.45 1 0 0.0 0.00 1.0e+00 ALDOA
Age at first live birth 1.92 2 0 0.0 0.00 1.0e+00 NEIL2 TEX15
Pulse wave peak to peak time 2.42 2 0 0.0 0.00 1.0e+00 FES NEIL2
Qualifications: College or University degree 2.02 3 1 3.0 0.00 1.0e+00 ALDOA TEX15 ZNF48
Medication for pain relief, constipation, heartburn 1.85 1 0 0.0 0.00 1.0e+00 TEX15
Neck or shoulder pain in last month 1.99 1 0 0.0 0.00 1.0e+00 ALDOA
Medication: Blood pressure 15.43 10 6 18.2 0.93 9.9e-05 ACP2 ARHGAP42 ERI1 FES PDLIM4 SLC4A7 TNNT3 ULK3 WNT2B ZNF48
Angina (self-reported) 4.68 1 1 3.0 0.00 1.0e+00 FES
Medication: Seretide 50 evohaler 1.75 1 0 0.0 0.00 1.0e+00 PDLIM4
Mean time to correctly identify matches 1.29 1 0 0.0 0.00 1.0e+00 FES
Heart disease (mother) 2.27 1 0 0.0 0.00 1.0e+00 FES
Whole body fat mass 3.96 4 3 9.1 0.96 3.8e-02 ALDOA ERI1 TEX15 ZNF48
Leg fat mass (right) 3.97 4 3 9.1 0.97 2.7e-02 ALDOA ERI1 TEX15 ZNF48
Arm predicted mass (right) 4.93 6 3 9.1 0.53 2.8e-01 ALDOA ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48
Pulse rate, automated reading 1.78 3 0 0.0 0.00 1.0e+00 ACP2 SLC4A7 WNT2B
Alcohol intake frequency. 3.51 3 2 6.1 0.00 1.0e+00 ALDOA TEX15 ZNF48
Comparative height size at age 10 2.91 4 2 6.1 -0.40 6.0e-01 ACP2 ALDOA FES PDLIM4
Suffer from 'nerves' 2.59 2 0 0.0 0.00 1.0e+00 ERI1 NEIL2
Overall health rating 2.76 1 1 3.0 0.00 1.0e+00 TEX15
Age at last live birth 2.56 2 0 0.0 0.00 1.0e+00 ERI1 NEIL2
Qualifications: NVQ or HND or HNC or equivalent 1.75 1 0 0.0 0.00 1.0e+00 ALDOA
Medication: Aspirin 4.67 2 1 3.0 0.00 1.0e+00 FES PIGV
Hypertension (Self-reported) 20.90 15 11 33.3 0.93 3.3e-07 ACP2 ALDOA ARHGAP42 ERI1 FES MGRN1 NEIL2 PDLIM4 PIGV SLC4A7 TEX15 TNNT3 ULK3 WNT2B ZNF48
Illnesses of father: Heart disease 3.47 1 1 3.0 0.00 1.0e+00 FES
Forced expiratory volume in 1-second (FEV1), predicted 2.50 2 1 3.0 0.00 1.0e+00 MGRN1 PDLIM4
Whole body fat-free mass 5.13 8 3 9.1 0.33 4.2e-01 ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 SLC4A7 ZNF48
Leg fat-free mass (right) 5.43 7 3 9.1 0.32 4.8e-01 ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 ZNF48
Arm fat percentage (left) 3.56 4 3 9.1 0.98 2.0e-02 ALDOA ERI1 TEX15 ZNF48
Average weekly red wine intake 1.50 1 0 0.0 0.00 1.0e+00 ULK3
Handedness (chirality/laterality): Left-handed 1.41 1 0 0.0 0.00 1.0e+00 FES
Mood swings 3.12 4 0 0.0 0.48 5.2e-01 ACP2 ERI1 NEIL2 TEX15
Diabetes diagnosed by doctor 1.54 1 0 0.0 0.00 1.0e+00 PIGV
Mouth/teeth dental problems: Mouth ulcers 1.48 1 0 0.0 0.00 1.0e+00 SLC4A7
Medication for cholesterol 9.68 8 3 9.1 -0.98 1.5e-05 ARHGAP42 FES MGRN1 PIGV SLC4A7 TNNT3 WNT2B ZNF48
Breast cancer (self-reported) 3.10 1 1 3.0 0.00 1.0e+00 SLC4A7
Asthma (self-reported) 4.09 2 1 3.0 0.00 1.0e+00 FES PDLIM4
Osteoporosis (self-reported) 1.13 1 0 0.0 0.00 1.0e+00 ERI1
Osteoarthritis (self-reported) 1.77 2 0 0.0 0.00 1.0e+00 PDLIM4 ULK3
Medication: Aspirin 4.88 3 1 3.0 0.00 1.0e+00 FES PIGV TEX15
Illnesses of father: None of the above (group 1) 3.80 1 1 3.0 0.00 1.0e+00 FES
Smoking status: Current 2.22 1 0 0.0 0.00 1.0e+00 ERI1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.38 3 1 3.0 0.00 1.0e+00 ALDOA NEIL2 ZNF48
Whole body water mass 5.19 8 3 9.1 0.33 4.2e-01 ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 SLC4A7 ZNF48
Leg predicted mass (right) 5.39 7 3 9.1 0.32 4.9e-01 ALDOA ARHGAP42 ERI1 FES NEIL2 PDLIM4 ZNF48
Arm fat mass (left) 4.63 5 3 9.1 0.95 1.5e-02 ALDOA ERI1 NEIL2 TEX15 ZNF48
Number of self-reported non-cancer illnesses 3.64 3 0 0.0 0.00 1.0e+00 ARHGAP42 MGRN1 PDLIM4
Miserableness 3.31 3 1 3.0 0.00 1.0e+00 ACP2 ERI1 NEIL2
Guilty feelings 3.00 3 0 0.0 0.00 1.0e+00 ACP2 ERI1 NEIL2
Eye problems/disorders: Glaucoma 2.37 2 0 0.0 0.00 1.0e+00 ACP2 TEX15
Medication: Blood pressure 17.97 14 8 24.2 0.96 6.2e-08 ACP2 ARHGAP42 ERI1 FES MGRN1 NEIL2 PDLIM4 PIGV SLC4A7 TEX15 TNNT3 ULK3 WNT2B ZNF48
Supplements: Fish oil (including cod liver oil) 1.62 1 0 0.0 0.00 1.0e+00 ERI1
High cholesterol (Self-reported) 4.45 3 1 3.0 0.00 1.0e+00 ARHGAP42 FES PIGV
Medication: Lisinopril 5.81 5 0 0.0 1.00 3.0e-04 ACP2 ARHGAP42 FES SLC4A7 ULK3
Illnesses of father: High blood pressure 6.35 5 1 3.0 0.96 9.9e-03 ACP2 ARHGAP42 FES SLC4A7 TEX15
Ever smoked 0.92 1 0 0.0 0.00 1.0e+00 FES
Basal metabolic rate 5.34 7 3 9.1 0.42 3.5e-01 ALDOA ARHGAP42 ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48
Leg fat percentage (left) 3.57 5 3 9.1 0.97 7.1e-03 ALDOA ERI1 PDLIM4 TEX15 ZNF48
Arm fat-free mass (left) 5.08 6 3 9.1 0.53 2.8e-01 ALDOA ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48
Average weekly beer plus cider intake 1.80 1 0 0.0 0.00 1.0e+00 ERI1
Irritability 3.75 2 1 3.0 0.00 1.0e+00 ERI1 NEIL2
Risk taking 1.75 2 0 0.0 0.00 1.0e+00 ERI1 FES
Diastolic blood pressure, automated reading 12.63 12 7 21.2 0.90 7.2e-05 ACP2 ARHGAP42 ERI1 FES MGRN1 NEIL2 PDLIM4 PIGV TNNT3 ULK3 WNT2B ZNF48
Commuting to job workplace: Cycle 1.62 1 0 0.0 0.00 1.0e+00 TEX15
Myopia 1.54 1 0 0.0 0.00 1.0e+00 WNT2B
Vascular/heart problems diagnosed by doctor 20.84 15 10 30.3 -0.93 6.9e-07 ACP2 ALDOA ARHGAP42 ERI1 FES MGRN1 NEIL2 PDLIM4 PIGV SLC4A7 TEX15 TNNT3 ULK3 WNT2B ZNF48
Cholesterol lowering medication 3.32 3 0 0.0 0.00 1.0e+00 MGRN1 PIGV ZNF48
Heart attack/myocardial infarction (self-reported) 2.53 1 1 3.0 0.00 1.0e+00 FES
Heart disease (siblings) 1.69 1 0 0.0 0.00 1.0e+00 FES
Impedance of whole body 4.92 7 4 12.1 -0.77 4.1e-02 ALDOA ARHGAP42 ERI1 NEIL2 SLC4A7 TNNT3 ZNF48
Leg fat mass (left) 4.29 4 3 9.1 0.97 2.8e-02 ALDOA ERI1 TEX15 ZNF48
Arm predicted mass (left) 5.21 6 3 9.1 0.53 2.8e-01 ALDOA ERI1 NEIL2 PDLIM4 SLC4A7 ZNF48

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.55
GTEx Adipose Visceral Omentum 1 0.0491 1.57
GTEx Adrenal Gland 0 0.0000 1.59
GTEx Artery Aorta 2 0.0672 1.61
GTEx Artery Coronary 0 0.0000 1.42
GTEx Artery Tibial 3 0.0798 1.53
GTEx Brain Caudate basal ganglia 0 0.0000 1.59
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.54
GTEx Brain Cerebellum 0 0.0000 1.53
GTEx Brain Cortex 0 0.0000 1.49
GTEx Brain Frontal Cortex BA9 0 0.0000 1.56
GTEx Brain Hippocampus 0 0.0000 1.39
GTEx Brain Hypothalamus 0 0.0000 1.50
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.51
GTEx Brain Putamen basal ganglia 0 0.0000 1.51
GTEx Breast Mammary Tissue 0 0.0000 1.59
GTEx Breast Mammary Tissue (Male) 1 0.0838 1.54
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.53
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.57
GTEx Cells Transformed fibroblasts 4 0.0953 1.55
GTEx Colon Sigmoid 0 0.0000 1.47
GTEx Colon Transverse 0 0.0000 1.58
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.50
GTEx Esophagus Mucosa 0 0.0000 1.58
GTEx Esophagus Muscularis 2 0.0619 1.57
GTEx Heart Atrial Appendage 1 0.0633 1.59
GTEx Heart Left Ventricle 2 0.1307 1.55
GTEx Liver 0 0.0000 1.52
GTEx Lung 1 0.0348 1.53
GTEx Muscle Skeletal 3 0.1038 1.47
GTEx Nerve Tibial 2 0.0463 1.47
GTEx Ovary 0 0.0000 1.54
GTEx Pancreas 1 0.0613 1.55
GTEx Pituitary 0 0.0000 1.53
GTEx Prostate 0 0.0000 1.64
GTEx Skin Not Sun Exposed Suprapubic 2 0.0813 1.60
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.58
GTEx Small Intestine Terminal Ileum 1 0.2169 1.67
GTEx Spleen 0 0.0000 1.48
GTEx Stomach 0 0.0000 1.52
GTEx Testis 1 0.0317 1.52
GTEx Thyroid 4 0.1000 1.53
GTEx Uterus 0 0.0000 1.51
GTEx Vagina 1 0.1575 1.52
GTEx Whole Blood 0 0.0000 1.55
METSIM Adipose 3 0.0651 1.52
NTR Blood 2 0.0833 1.55
ROSMAP Brain Pre-frontal Cortex 3 0.0683 1.64
YFS Blood 2 0.0433 1.44
CommonMind Brain Pre-frontal Cortex 5 0.0930 1.53
TCGA Breast Tumor 0 0.0000 1.50
TCGA Breast Normal 1 0.0238 1.41
TCGA Ovarian Tumor 1 0.0342 1.39
TCGA Prostate Tumor 0 0.0000 1.55