Hub : Traits :

Diabetes diagnosed by doctor

96 significantly associated models · 42 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 39295972 40737589 3 1 1.8e-08 7.2e-07 6.6e-02 86 RP11-69E11.4
2 1 119761038 120687115 2 1 4.2e-08 3.9e-08 1.0e+00 100 NOTCH2
3 1 213759712 215206914 1 1 6.9e-08 3.5e-09 1.6e-03 72 SMYD2
4 2 26655745 28402863 6 1 4.2e-10 7.6e-13 4.2e-04 76 AC074117.10
5 2 42767044 44157441 1 1 3.8e-12 4.7e-12 1.0e+00 100 AC010883.5
6 3 48757291 50800146 4 2 1.0e-08 1.1e-08 9.3e-02 91 RBM6 TCTA
7 4 5575751 7002344 1 1 4.7e-16 8.8e-18 1.0e-04 80 WFS1
8 4 103020804 104487361 1 1 1.2e-07 1.8e-05 4.5e-04 33 UBE2D3
9 6 6582123 8009760 1 1 1.3e-10 1.5e-07 9.2e-04 60 SSR1
10 7 73624615 74494207 1 1 1.1e-07 3.3e-07 1.0e+00 100 PMS2P5
11 7 102334106 103489729 1 1 8.9e-08 8.6e-07 4.9e-01 98 NAPEPLD
12 8 40811597 42450441 1 2 3.9e-10 7.1e-11 1.0e+00 100 ANK1
13 8 145504343 146293414 1 1 1.6e-07 1.1e-05 9.5e-06 -1 ZNF517
14 10 11693166 13569805 1 1 8.8e-08 1.2e-08 1.6e-02 82 CAMK1D
15 10 80443273 81901722 1 1 1.4e-08 5.0e-12 3.6e-05 64 ZCCHC24
16 10 93657148 95151622 3 1 8.1e-18 1.7e-18 2.1e-03 88 EIF2S2P3
17 10 113511441 115622375 2 1 4.1e-45 3.7e-150 6.3e-113 25 TCF7L2
18 11 16691743 18106069 3 1 1.2e-09 1.5e-10 1.0e+00 100 KCNJ11
19 11 64845438 66240882 1 1 3.0e-07 2.1e-07 1.0e+00 100 DKFZp761E198
20 15 89680384 91152345 1 1 6.0e-09 1.8e-08 3.5e-01 97 AP3S2
21 16 52772129 54224557 1 1 4.5e-08 1.4e-22 7.4e-21 8 RBL2
22 16 69323837 70794031 1 1 5.2e-08 6.9e-10 7.4e-05 59 PDXDC2
23 17 40120771 41510850 1 1 5.1e-08 4.8e-08 1.0e+00 100 TUBG2
24 19 19063077 20387532 1 1 4.1e-07 1.3e-07 3.5e-02 84 ATP13A1
25 20 31701333 33116483 1 1 1.7e-07 2.5e-07 1.0e+00 100 CHMP4B
26 20 61679007 62912463 1 1 3.1e-08 4.6e-08 1.0e+00 100 ZBTB46

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 3.63 6 3 9.1 -1.00 2.6e-05 AC010883.5 AC074117.10 NOTCH2 PMS2P5 TCTA TUBG2
Irritable Bowel Disease (IBD) 3.09 5 2 6.1 -0.75 1.4e-01 AC010883.5 AC074117.10 PMS2P5 RBM6 TUBG2
Ulcerative Colitis (UC) 2.25 2 0 0.0 0.00 1.0e+00 AC010883.5 RBM6
Reaction Time 1.53 1 0 0.0 0.00 1.0e+00 TCTA
Verbal and Numeric Reasoning (VNR) 2.51 3 2 6.1 0.00 1.0e+00 RBL2 RBM6 TCTA
Breast Cancer 2.50 3 1 3.0 0.00 1.0e+00 NOTCH2 PMS2P5 TCF7L2
Age at First Birth 2.84 2 2 6.1 0.00 1.0e+00 RBM6 TCTA
Body Mass Index (BMI) (2010) 1.75 1 0 0.0 0.00 1.0e+00 RBM6
Coronary Artery Disease (CAD) 2.16 1 0 0.0 0.00 1.0e+00 RBM6
Crohns Disease (2012) 2.74 4 0 0.0 1.00 3.8e-03 AC010883.5 NOTCH2 RBM6 TCTA
Fasting Glucose 4.28 2 1 3.0 0.00 1.0e+00 AC074117.10 SMYD2
HDL Cholesterol 2.21 2 1 3.0 0.00 1.0e+00 RBM6 RP11-69E11.4
LDL Cholesterol 2.17 1 1 3.0 0.00 1.0e+00 ATP13A1
Schizophrenia 1.19 1 0 0.0 0.00 1.0e+00 KCNJ11
Triglycerides 11.65 3 2 6.1 0.00 1.0e+00 AC074117.10 ATP13A1 RP11-69E11.4
Type 2 Diabetes (T2D) 10.21 8 3 9.1 -0.96 1.1e-04 AC010883.5 ANK1 EIF2S2P3 KCNJ11 SSR1 TCF7L2 WFS1 ZCCHC24
Ulcerative Colitis 2.18 1 0 0.0 0.00 1.0e+00 AC010883.5
Blood Eosinophil Count 1.07 3 3 9.1 0.00 1.0e+00 AC010883.5 EIF2S2P3 RBM6
Blood Platelet Count 3.18 9 7 21.2 0.16 6.7e-01 AC010883.5 AC074117.10 AP3S2 ATP13A1 DKFZp761E198 EIF2S2P3 KCNJ11 RP11-69E11.4 ZCCHC24
Blood Red Count 1.09 5 2 6.1 -0.93 2.2e-02 ATP13A1 PDXDC2 TCTA UBE2D3 ZBTB46
Blood White Count 2.24 7 4 12.1 -0.25 5.9e-01 AC074117.10 ATP13A1 RBM6 RP11-69E11.4 TUBG2 ZBTB46 ZCCHC24
Heel T-Score 2.39 10 6 18.2 -0.61 6.2e-02 AC010883.5 ATP13A1 DKFZp761E198 PMS2P5 RBM6 RP11-69E11.4 SMYD2 SSR1 TCTA TUBG2
BMI 3.79 12 8 24.2 -0.40 2.0e-01 DKFZp761E198 KCNJ11 NAPEPLD PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA TUBG2 UBE2D3 ZCCHC24
Height 1.38 8 7 21.2 0.09 8.3e-01 AC010883.5 AC074117.10 AP3S2 ATP13A1 KCNJ11 PDXDC2 RBL2 SSR1
Waist Hip Ratio (WHR) 2.90 10 7 21.2 -0.85 2.0e-03 AC010883.5 ATP13A1 DKFZp761E198 EIF2S2P3 KCNJ11 RBL2 TCF7L2 TCTA TUBG2 ZCCHC24
Systolic Blood Pressure 2.82 10 4 12.1 -0.79 6.3e-03 AC074117.10 ATP13A1 CAMK1D KCNJ11 PDXDC2 PMS2P5 TCF7L2 TCTA ZBTB46 ZNF517
Smoking Status 0.94 1 0 0.0 0.00 1.0e+00 KCNJ11
Allergy or Eczema 2.09 4 1 3.0 0.48 5.2e-01 AC010883.5 AC074117.10 TUBG2 UBE2D3
Cardiovascular Disease 3.56 10 4 12.1 -0.70 2.5e-02 AC074117.10 KCNJ11 PDXDC2 PMS2P5 RP11-69E11.4 TCTA TUBG2 UBE2D3 ZBTB46 ZNF517
Hypothyroidism (self reported) 1.13 2 0 0.0 0.00 1.0e+00 AC010883.5 ZBTB46
Respiratory disease 1.62 2 0 0.0 0.00 1.0e+00 EIF2S2P3 RBM6
Type 2 Diabetes (T2D) 25.84 27 21 63.6 -0.99 1.4e-25 AC010883.5 AC074117.10 ANK1 AP3S2 ATP13A1 CAMK1D CHMP4B DKFZp761E198 EIF2S2P3 KCNJ11 NAPEPLD NOTCH2 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 SMYD2 SSR1 TCF7L2 TCTA TUBG2 UBE2D3 WFS1 ZBTB46 ZCCHC24 ZNF517
Lung FEV1/FVC ratio 2.22 3 3 9.1 0.00 1.0e+00 AC010883.5 CAMK1D RP11-69E11.4
Lung FVC 1.58 5 3 9.1 0.68 2.0e-01 CAMK1D CHMP4B SSR1 ZBTB46 ZCCHC24
Neuroticism 1.13 1 0 0.0 0.00 1.0e+00 RBM6
Chronotype (morning person) 1.62 1 1 3.0 0.00 1.0e+00 NAPEPLD
Hair Pigment 1.11 8 3 9.1 0.59 1.2e-01 AC010883.5 AC074117.10 CHMP4B DKFZp761E198 NAPEPLD RP11-69E11.4 SSR1 ZCCHC24
Tanning 1.85 3 3 9.1 0.00 1.0e+00 AC074117.10 CHMP4B NOTCH2
Hand grip strength (left) 1.08 1 0 0.0 0.00 1.0e+00 PDXDC2
Number of treatments/medications taken 4.10 4 2 6.1 0.62 3.8e-01 AC074117.10 PMS2P5 RBM6 UBE2D3
Relative age of first facial hair 1.50 2 0 0.0 0.00 1.0e+00 AC074117.10 PMS2P5
Other serious medical condition/disability diagnosed by doctor 1.09 1 0 0.0 0.00 1.0e+00 PMS2P5
Systolic blood pressure, automated reading 2.50 6 2 6.1 0.99 6.7e-05 CAMK1D KCNJ11 PDXDC2 PMS2P5 TCTA ZBTB46
Eye problems/disorders: Diabetes related eye disease 4.51 1 0 0.0 0.00 1.0e+00 TCF7L2
Angina 1.79 1 0 0.0 0.00 1.0e+00 ZBTB46
Medication: Co-codamol 1.30 1 0 0.0 0.00 1.0e+00 RBM6
Medication: Metformin 17.09 21 6 18.2 0.99 2.2e-20 AC010883.5 AC074117.10 ANK1 AP3S2 CAMK1D DKFZp761E198 EIF2S2P3 KCNJ11 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 SSR1 TCF7L2 TCTA TUBG2 UBE2D3 WFS1 ZBTB46 ZCCHC24
Diabetes (father) 10.88 8 3 9.1 1.00 1.6e-07 AC010883.5 AC074117.10 ANK1 AP3S2 EIF2S2P3 SSR1 TCF7L2 TUBG2
Diabetes (mother) 10.02 8 3 9.1 0.99 8.2e-06 AC010883.5 ANK1 ATP13A1 CAMK1D EIF2S2P3 NAPEPLD TCF7L2 WFS1
Pack years adult smoking proportion 1.97 3 0 0.0 0.00 1.0e+00 PDXDC2 PMS2P5 TUBG2
Impedance of leg (right) 2.41 10 6 18.2 -0.24 5.1e-01 AC010883.5 AC074117.10 ATP13A1 KCNJ11 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 TUBG2
Leg fat-free mass (left) 2.45 8 5 15.2 0.50 2.1e-01 AC074117.10 ATP13A1 NAPEPLD RBL2 RBM6 RP11-69E11.4 TCTA TUBG2
Trunk fat percentage 2.43 7 3 9.1 0.67 1.0e-01 ATP13A1 PDXDC2 PMS2P5 RBM6 TCTA TUBG2 ZCCHC24
Hand grip strength (right) 1.19 1 0 0.0 0.00 1.0e+00 PDXDC2
Maternal smoking around birth 2.02 1 0 0.0 0.00 1.0e+00 RBM6
Fed-up feelings 1.80 2 0 0.0 0.00 1.0e+00 AC010883.5 RBM6
Relative age voice broke 1.74 3 0 0.0 0.00 1.0e+00 PDXDC2 PMS2P5 TCTA
Taking other prescription medications 3.20 3 1 3.0 0.00 1.0e+00 PMS2P5 RBM6 UBE2D3
Age when periods started (menarche) 2.18 3 2 6.1 0.00 1.0e+00 DKFZp761E198 PDXDC2 PMS2P5
Heel bone mineral density (BMD) T-score, automated (left) 2.56 5 1 3.0 0.57 3.2e-01 AC010883.5 DKFZp761E198 PMS2P5 RBM6 TCTA
Serious illness, injury or assault to yourself 1.74 1 0 0.0 0.00 1.0e+00 PDXDC2
High blood pressure 3.30 9 2 6.1 0.99 7.3e-07 CAMK1D KCNJ11 PDXDC2 PMS2P5 RBL2 TCTA UBE2D3 ZBTB46 ZNF517
Hayfever, allergic rhinitis or eczema 2.24 4 1 3.0 -0.27 7.3e-01 AC010883.5 AC074117.10 TUBG2 UBE2D3
Sitting height 1.55 6 5 15.2 0.03 9.6e-01 AC074117.10 PDXDC2 RBL2 RP11-69E11.4 SSR1 ZCCHC24
Body mass index (BMI) 4.07 11 6 18.2 0.39 2.3e-01 DKFZp761E198 KCNJ11 NAPEPLD PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA TUBG2 UBE2D3
Impedance of leg (left) 2.61 11 5 15.2 -0.18 5.9e-01 AC010883.5 AC074117.10 ATP13A1 KCNJ11 NOTCH2 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 TUBG2
Leg predicted mass (left) 2.44 7 5 15.2 0.44 3.2e-01 AC074117.10 ATP13A1 NAPEPLD RBL2 RBM6 RP11-69E11.4 TUBG2
Trunk fat mass 2.78 8 4 12.1 0.30 4.6e-01 ATP13A1 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA TUBG2
Waist circumference 3.67 9 5 15.2 0.50 1.7e-01 DKFZp761E198 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA TUBG2 ZCCHC24
Nervous feelings 0.92 1 0 0.0 0.00 1.0e+00 PDXDC2
Frequency of tenseness / restlessness in last 2 weeks 1.28 1 0 0.0 0.00 1.0e+00 RBM6
Hearing difficulty/problems with background noise 1.43 1 0 0.0 0.00 1.0e+00 TUBG2
Had menopause 1.69 1 1 3.0 0.00 1.0e+00 AC074117.10
Forced vital capacity (FVC) 1.64 5 1 3.0 -0.65 2.4e-01 CAMK1D PDXDC2 SMYD2 SSR1 ZCCHC24
Heel bone mineral density (BMD) T-score, automated (right) 2.24 3 1 3.0 0.00 1.0e+00 DKFZp761E198 RBM6 TCTA
Ever unenthusiastic/disinterested for a whole week 1.55 1 0 0.0 0.00 1.0e+00 RBM6
Qualifications: None of the above 2.00 3 1 3.0 0.00 1.0e+00 ATP13A1 RBL2 RBM6
Mouth/teeth dental problems 1.98 1 0 0.0 0.00 1.0e+00 PMS2P5
Heart attack 1.81 1 0 0.0 0.00 1.0e+00 AC010883.5
Allergy 1.85 3 0 0.0 0.00 1.0e+00 AC010883.5 TUBG2 UBE2D3
Diabetes (self-reported) 22.78 27 18 54.5 0.99 1.5e-27 AC010883.5 AC074117.10 ANK1 AP3S2 ATP13A1 CAMK1D CHMP4B DKFZp761E198 EIF2S2P3 KCNJ11 NAPEPLD NOTCH2 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 SMYD2 SSR1 TCF7L2 TCTA TUBG2 UBE2D3 WFS1 ZBTB46 ZCCHC24 ZNF517
Hayfever/allergic rhinitis (self-reported) 1.62 2 0 0.0 0.00 1.0e+00 NAPEPLD TUBG2
Medication: Ramipril 2.81 1 0 0.0 0.00 1.0e+00 UBE2D3
Medication: Simvastatin 3.54 4 0 0.0 0.58 4.2e-01 AC074117.10 ATP13A1 PDXDC2 TCF7L2
Fluid intelligence score 2.96 5 1 3.0 -0.69 2.0e-01 ATP13A1 KCNJ11 RBL2 RBM6 TCTA
Illnesses of siblings 2.59 1 0 0.0 0.00 1.0e+00 TUBG2
Neuroticism score 1.45 3 0 0.0 0.00 1.0e+00 AC010883.5 PDXDC2 RBM6
Weight 2.97 11 4 12.1 0.31 3.5e-01 AC074117.10 ATP13A1 NAPEPLD PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 TCF7L2 TCTA TUBG2
Impedance of arm (right) 2.84 7 4 12.1 -0.23 6.2e-01 AC074117.10 DKFZp761E198 KCNJ11 RBM6 TCF7L2 TCTA UBE2D3
Arm fat percentage (right) 3.16 8 3 9.1 0.27 5.2e-01 ATP13A1 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA TUBG2
Trunk fat-free mass 2.05 6 3 9.1 0.74 9.6e-02 AC074117.10 NAPEPLD RBL2 RBM6 RP11-69E11.4 SSR1
Hip circumference 2.72 8 3 9.1 -0.06 8.8e-01 ATP13A1 NAPEPLD PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 TCF7L2
Alcohol intake versus 10 years previously 3.46 3 2 6.1 0.00 1.0e+00 AC074117.10 RBM6 RP11-69E11.4
Father's age at death 1.17 1 0 0.0 0.00 1.0e+00 TUBG2
Worrier / anxious feelings 1.12 2 0 0.0 0.00 1.0e+00 PDXDC2 TCF7L2
Number of live births 1.81 1 0 0.0 0.00 1.0e+00 RBM6
Forced expiratory volume in 1-second (FEV1) 1.88 4 1 3.0 -0.96 3.8e-02 CAMK1D PDXDC2 SMYD2 ZCCHC24
Pulse rate 2.86 3 1 3.0 0.00 1.0e+00 AC074117.10 RBL2 TCTA
Qualifications: A levels/AS levels or equivalent 2.51 3 1 3.0 0.00 1.0e+00 ATP13A1 RBM6 TCTA
Mouth/teeth dental problems: Dentures 2.52 2 1 3.0 0.00 1.0e+00 PMS2P5 RBM6
Asthma 2.00 4 0 0.0 0.23 7.7e-01 DKFZp761E198 EIF2S2P3 RBM6 TUBG2
Medication: Cholesterol lowering 4.97 6 2 6.1 0.47 3.5e-01 AC074117.10 ATP13A1 CHMP4B PDXDC2 TCF7L2 TCTA
Prospective memory result 1.88 1 0 0.0 0.00 1.0e+00 RBM6
Illnesses of mother 2.04 1 0 0.0 0.00 1.0e+00 TCTA
Forced expiratory volume in 1-second (FEV1), Best measure 2.03 3 1 3.0 0.00 1.0e+00 CAMK1D PDXDC2 ZCCHC24
Impedance of arm (left) 2.86 8 4 12.1 -0.27 5.1e-01 AC010883.5 AC074117.10 DKFZp761E198 KCNJ11 RBM6 TCF7L2 TCTA UBE2D3
Arm fat mass (right) 3.40 9 5 15.2 0.46 2.2e-01 DKFZp761E198 NAPEPLD PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA TUBG2
Trunk predicted mass 2.04 6 3 9.1 0.74 9.6e-02 AC074117.10 NAPEPLD RBL2 RBM6 RP11-69E11.4 SSR1
Standing height 1.38 6 5 15.2 0.01 9.9e-01 AC074117.10 ATP13A1 KCNJ11 PDXDC2 RBL2 SSR1
Exposure to tobacco smoke at home 1.37 1 0 0.0 0.00 1.0e+00 RBM6
Breastfed as a baby 1.47 1 0 0.0 0.00 1.0e+00 TCTA
Hair/balding pattern: Pattern 4 1.47 2 0 0.0 0.00 1.0e+00 AC010883.5 NOTCH2
Birth weight of first child 2.34 3 0 0.0 0.00 1.0e+00 ATP13A1 RBL2 SSR1
Peak expiratory flow (PEF) 1.67 3 2 6.1 0.00 1.0e+00 AC010883.5 ATP13A1 CAMK1D
Ever highly irritable/argumentative for 2 days 1.81 1 1 3.0 0.00 1.0e+00 RBM6
Qualifications: O levels/GCSEs or equivalent 1.38 1 0 0.0 0.00 1.0e+00 RBM6
Medication for cholesterol, blood pressure or diabetes 4.34 7 1 3.0 -0.72 6.5e-02 AC074117.10 CAMK1D CHMP4B PDXDC2 RBM6 TCTA ZBTB46
Gout (self-reported) 4.04 1 1 3.0 0.00 1.0e+00 AC074117.10
Medication: Ventolin 100micrograms inhaler 1.77 1 0 0.0 0.00 1.0e+00 RBM6
Birth weight 3.94 4 2 6.1 0.01 9.9e-01 ANK1 EIF2S2P3 SMYD2 SSR1
Chronic bronchitis/emphysema (mother) 1.60 1 0 0.0 0.00 1.0e+00 RBM6
Forced vital capacity (FVC), Best measure 1.71 6 2 6.1 -0.66 1.6e-01 CAMK1D PDXDC2 RBM6 SMYD2 SSR1 ZCCHC24
Body fat percentage 2.91 7 4 12.1 0.14 7.6e-01 PDXDC2 PMS2P5 RBM6 TCF7L2 TCTA TUBG2 ZCCHC24
Leg fat percentage (right) 3.64 9 4 12.1 0.41 2.8e-01 DKFZp761E198 PDXDC2 PMS2P5 RBL2 RBM6 TCF7L2 TCTA TUBG2 ZCCHC24
Arm fat-free mass (right) 2.47 6 3 9.1 0.81 5.1e-02 AC074117.10 NAPEPLD RBL2 RBM6 SSR1 TCTA
Exposure to tobacco smoke outside home 1.47 1 0 0.0 0.00 1.0e+00 RBM6
Comparative body size at age 10 1.26 2 0 0.0 0.00 1.0e+00 AC074117.10 PDXDC2
Wheeze or whistling in the chest in last year 2.25 1 1 3.0 0.00 1.0e+00 RBM6
Age at first live birth 2.90 2 1 3.0 0.00 1.0e+00 RBM6 TCTA
Qualifications: College or University degree 2.52 2 1 3.0 0.00 1.0e+00 RBL2 RBM6
Mouth/teeth dental problems: Loose teeth 1.71 1 0 0.0 0.00 1.0e+00 TUBG2
Medication for pain relief, constipation, heartburn 1.70 1 0 0.0 0.00 1.0e+00 UBE2D3
Neck or shoulder pain in last month 1.36 1 0 0.0 0.00 1.0e+00 RP11-69E11.4
Medication: Blood pressure 3.03 5 0 0.0 1.00 2.5e-05 CAMK1D PDXDC2 PMS2P5 UBE2D3 ZBTB46
Angina (self-reported) 1.73 1 0 0.0 0.00 1.0e+00 ZBTB46
Medication: Allopurinol 3.35 1 1 3.0 0.00 1.0e+00 AC074117.10
Medication: Seretide 50 evohaler 1.30 1 0 0.0 0.00 1.0e+00 RBM6
Mean time to correctly identify matches 1.33 1 0 0.0 0.00 1.0e+00 TCTA
Whole body fat mass 3.20 8 4 12.1 0.27 5.2e-01 ATP13A1 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA TUBG2
Leg fat mass (right) 3.77 9 4 12.1 0.39 2.9e-01 DKFZp761E198 NAPEPLD PDXDC2 PMS2P5 RBM6 TCF7L2 TCTA TUBG2 ZCCHC24
Arm predicted mass (right) 2.42 6 2 6.1 0.80 5.4e-02 AC074117.10 NAPEPLD RBL2 RBM6 SSR1 TCTA
Pulse rate, automated reading 4.83 9 6 18.2 0.52 1.5e-01 AC074117.10 DKFZp761E198 EIF2S2P3 PDXDC2 RBL2 RBM6 RP11-69E11.4 TCTA WFS1
Alcohol intake frequency. 4.89 7 5 15.2 0.47 2.9e-01 AC074117.10 PDXDC2 PMS2P5 RBM6 TCTA TUBG2 UBE2D3
Comparative height size at age 10 1.58 6 4 12.1 0.09 8.7e-01 AC010883.5 AC074117.10 ATP13A1 EIF2S2P3 KCNJ11 RBL2
Overall health rating 3.32 5 2 6.1 0.99 5.3e-04 DKFZp761E198 PMS2P5 RBL2 RBM6 UBE2D3
Chest pain or discomfort 1.65 1 0 0.0 0.00 1.0e+00 ZBTB46
Age at last live birth 3.29 2 1 3.0 0.00 1.0e+00 EIF2S2P3 RBM6
Leg pain on walking 1.37 1 0 0.0 0.00 1.0e+00 RBM6
Qualifications: NVQ or HND or HNC or equivalent 1.70 1 0 0.0 0.00 1.0e+00 RBM6
Knee pain experienced in last month 1.59 2 0 0.0 0.00 1.0e+00 RBM6 ZCCHC24
Hypertension (Self-reported) 3.41 9 3 9.1 0.99 8.4e-07 CAMK1D KCNJ11 PDXDC2 PMS2P5 RBL2 TCTA UBE2D3 ZBTB46 ZNF517
Illnesses of father: Heart disease 2.33 2 0 0.0 0.00 1.0e+00 ATP13A1 ZCCHC24
Illnesses of siblings: Diabetes 6.93 8 2 6.1 0.97 1.0e-04 AC010883.5 CAMK1D EIF2S2P3 PMS2P5 RBM6 TCF7L2 TUBG2 WFS1
Forced expiratory volume in 1-second (FEV1), predicted 1.32 1 0 0.0 0.00 1.0e+00 KCNJ11
Whole body fat-free mass 2.24 8 3 9.1 0.56 1.5e-01 AC074117.10 ATP13A1 NAPEPLD RBL2 RBM6 RP11-69E11.4 SSR1 TCTA
Leg fat-free mass (right) 2.32 6 5 15.2 0.28 5.8e-01 AC074117.10 ATP13A1 RBL2 RBM6 RP11-69E11.4 TUBG2
Arm fat percentage (left) 3.24 8 3 9.1 0.26 5.3e-01 ATP13A1 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA TUBG2
Average weekly red wine intake 1.46 1 0 0.0 0.00 1.0e+00 RBM6
Mood swings 1.87 2 1 3.0 0.00 1.0e+00 AC010883.5 RBM6
Long-standing illness, disability or infirmity 3.30 4 0 0.0 1.00 3.3e-03 PMS2P5 RBM6 RP11-69E11.4 ZBTB46
Qualifications: nursing, teaching 1.76 2 0 0.0 0.00 1.0e+00 RBM6 TCF7L2
Eye problems/disorders: Cataract 1.46 1 0 0.0 0.00 1.0e+00 CHMP4B
Mouth/teeth dental problems: Mouth ulcers 1.35 1 0 0.0 0.00 1.0e+00 TUBG2
Medication for cholesterol 3.12 4 0 0.0 -0.51 4.9e-01 AC074117.10 RBL2 UBE2D3 ZBTB46
Asthma (self-reported) 1.91 3 0 0.0 0.00 1.0e+00 EIF2S2P3 RBM6 TUBG2
Osteoporosis (self-reported) 1.42 1 0 0.0 0.00 1.0e+00 TCTA
Medication: Gliclazide 8.20 5 1 3.0 0.99 1.0e-03 EIF2S2P3 KCNJ11 TCF7L2 UBE2D3 WFS1
Illnesses of father: None of the above (group 1) 3.01 1 0 0.0 0.00 1.0e+00 CAMK1D
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.24 1 1 3.0 0.00 1.0e+00 CAMK1D
Whole body water mass 2.27 8 3 9.1 0.56 1.5e-01 AC074117.10 ATP13A1 NAPEPLD RBL2 RBM6 RP11-69E11.4 SSR1 TCTA
Leg predicted mass (right) 2.31 6 5 15.2 0.29 5.8e-01 AC074117.10 ATP13A1 RBL2 RBM6 RP11-69E11.4 TUBG2
Arm fat mass (left) 3.42 9 4 12.1 0.36 3.5e-01 ATP13A1 NAPEPLD PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 TCTA TUBG2
Number of self-reported non-cancer illnesses 3.62 6 1 3.0 0.58 2.2e-01 AC074117.10 PDXDC2 PMS2P5 RBM6 UBE2D3 ZBTB46
Miserableness 1.76 1 1 3.0 0.00 1.0e+00 RBM6
Mother's age at death 1.83 1 0 0.0 0.00 1.0e+00 TUBG2
Financial situation satisfaction 1.74 1 0 0.0 0.00 1.0e+00 RBM6
Medication: Blood pressure 3.11 5 1 3.0 0.99 2.0e-03 ATP13A1 KCNJ11 PMS2P5 TCTA ZBTB46
High cholesterol (Self-reported) 4.75 3 2 6.1 0.00 1.0e+00 AC074117.10 ATP13A1 PDXDC2
Medication: Bendroflumethiazide 1.95 1 0 0.0 0.00 1.0e+00 ZNF517
Medication: Atorvastatin 3.54 2 1 3.0 0.00 1.0e+00 AC074117.10 TCF7L2
Basal metabolic rate 2.43 10 3 9.1 0.28 4.3e-01 AC074117.10 ATP13A1 NAPEPLD RBL2 RBM6 RP11-69E11.4 SSR1 TCF7L2 TCTA TUBG2
Leg fat percentage (left) 3.74 10 4 12.1 0.45 1.9e-01 DKFZp761E198 PDXDC2 PMS2P5 RBL2 RBM6 TCF7L2 TCTA TUBG2 UBE2D3 ZCCHC24
Arm fat-free mass (left) 2.56 6 2 6.1 0.81 5.3e-02 AC074117.10 NAPEPLD RBL2 RBM6 SSR1 TCTA
Number of operations (self-reported) 1.67 2 0 0.0 0.00 1.0e+00 RBM6 UBE2D3
Average weekly beer plus cider intake 1.31 1 0 0.0 0.00 1.0e+00 RBM6
Irritability 1.46 1 0 0.0 0.00 1.0e+00 AC010883.5
Age started oral contraceptive pill 1.30 1 0 0.0 0.00 1.0e+00 RBM6
Diastolic blood pressure, automated reading 2.00 5 2 6.1 0.30 6.2e-01 ATP13A1 PMS2P5 RBM6 TCF7L2 TCTA
Commuting to job workplace: Cycle 1.49 1 0 0.0 0.00 1.0e+00 RBL2
Vascular/heart problems diagnosed by doctor 3.31 7 2 6.1 -0.99 2.7e-05 KCNJ11 PDXDC2 PMS2P5 RBL2 TCTA UBE2D3 ZBTB46
Cholesterol lowering medication 3.68 2 1 3.0 0.00 1.0e+00 AC074117.10 TCF7L2
Pain experienced in last month 1.76 2 0 0.0 0.00 1.0e+00 DKFZp761E198 RBM6
Heart attack/myocardial infarction (self-reported) 1.65 1 0 0.0 0.00 1.0e+00 AC010883.5
Pack years of smoking 1.99 2 0 0.0 0.00 1.0e+00 PDXDC2 PMS2P5
Impedance of whole body 2.63 10 4 12.1 -0.14 6.9e-01 AC010883.5 AC074117.10 KCNJ11 NOTCH2 PDXDC2 PMS2P5 RBM6 RP11-69E11.4 TCF7L2 UBE2D3
Leg fat mass (left) 3.77 9 5 15.2 0.38 3.1e-01 DKFZp761E198 NAPEPLD PDXDC2 PMS2P5 RBM6 TCF7L2 TCTA TUBG2 ZCCHC24
Arm predicted mass (left) 2.58 6 2 6.1 0.80 5.7e-02 AC074117.10 NAPEPLD RBL2 RBM6 SSR1 TCTA

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.69
GTEx Adipose Visceral Omentum 0 0.0000 1.70
GTEx Adrenal Gland 2 0.1373 1.65
GTEx Artery Aorta 3 0.1008 1.79
GTEx Artery Coronary 1 0.0845 1.58
GTEx Artery Tibial 1 0.0266 1.71
GTEx Brain Caudate basal ganglia 0 0.0000 1.50
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.73
GTEx Brain Cerebellum 1 0.0505 1.79
GTEx Brain Cortex 1 0.0966 1.79
GTEx Brain Frontal Cortex BA9 0 0.0000 1.62
GTEx Brain Hippocampus 0 0.0000 1.63
GTEx Brain Hypothalamus 0 0.0000 1.46
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.61
GTEx Brain Putamen basal ganglia 0 0.0000 1.61
GTEx Breast Mammary Tissue 2 0.1013 1.70
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.66
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.68
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.66
GTEx Cells Transformed fibroblasts 4 0.0953 1.70
GTEx Colon Sigmoid 0 0.0000 1.66
GTEx Colon Transverse 1 0.0484 1.72
GTEx Esophagus Gastroesophageal Junction 3 0.2076 1.67
GTEx Esophagus Mucosa 5 0.1506 1.73
GTEx Esophagus Muscularis 3 0.0928 1.77
GTEx Heart Atrial Appendage 2 0.1267 1.71
GTEx Heart Left Ventricle 0 0.0000 1.62
GTEx Liver 1 0.1395 1.52
GTEx Lung 2 0.0696 1.72
GTEx Muscle Skeletal 2 0.0692 1.73
GTEx Nerve Tibial 2 0.0463 1.68
GTEx Ovary 1 0.1101 1.85
GTEx Pancreas 1 0.0613 1.72
GTEx Pituitary 1 0.0897 1.72
GTEx Prostate 1 0.1198 1.74
GTEx Skin Not Sun Exposed Suprapubic 3 0.1220 1.77
GTEx Skin Sun Exposed Lower leg 3 0.0824 1.68
GTEx Small Intestine Terminal Ileum 0 0.0000 1.58
GTEx Spleen 1 0.0709 1.59
GTEx Stomach 0 0.0000 1.63
GTEx Testis 5 0.1585 1.65
GTEx Thyroid 6 0.1500 1.80
GTEx Uterus 0 0.0000 1.55
GTEx Vagina 0 0.0000 1.68
GTEx Whole Blood 2 0.1004 1.69
METSIM Adipose 5 0.1085 1.64
NTR Blood 7 0.2914 1.62
ROSMAP Brain Pre-frontal Cortex 4 0.0911 1.62
YFS Blood 2 0.0433 1.61
CommonMind Brain Pre-frontal Cortex 7 0.1302 1.65
TCGA Breast Tumor 2 0.2608 1.61
TCGA Breast Normal 3 0.0713 1.54
TCGA Ovarian Tumor 0 0.0000 1.40
TCGA Prostate Tumor 2 0.0578 1.55