Hub : Genes

CHMP4B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2720	0.0510	0.0e+00	0.234	0.195	0.224	0.145	0.151	4.8e-28	2.8e-23	6.9e-27	3.1e-17	5.2e-18
2	GTEx	Cells EBV-transformed lymphocytes	0.1780	0.0770	7.1e-03	0.077	NA	0.027	NA	0.043	1.7e-03	NA	4.4e-02	NA	1.5e-02
3	METSIM	Adipose	0.0464	0.0237	4.5e-03	0.017	0.011	0.010	0.015	0.017	1.2e-03	7.2e-03	9.1e-03	2.4e-03	1.0e-03
4	NTR	Blood	0.0645	0.0188	9.9e-11	0.042	0.038	0.038	0.039	0.038	2.2e-13	3.1e-12	2.8e-12	1.6e-12	3.2e-12
5	YFS	Blood	0.1606	0.0338	0.0e+00	0.091	0.109	0.116	0.118	0.118	3.9e-28	9.5e-34	5.6e-36	1.9e-36	1.9e-36
6	TCGA	Stomach Adenocarcinoma	0.0780	0.0390	8.1e-03	0.036	0.025	0.020	NA	0.036	1.2e-03	5.9e-03	1.2e-02	NA	1.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.6	2.6	4.3	-1.8	-0.2	-1.9	-1.6	-1.3	-2.1
Bipolar Disorder or Schizophrenia	1.3	3.2	4.9	-2.0	-0.5	-2.2	-2.2	-1.9	-1.3
Depressed Affect (Nagel 2018)	0.7	1.4	2.6	-1.3	-1.4	-1.0	-1.0	-1.6	0.2
Depression (Nagel 2018)	1.2	1.8	5.2	-1.1	-2.3	-1.0	-0.8	-1.4	-0.7
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.6	-1.0	-0.4	-1.2	-1.1	-1.0	1.6
Neuroticism (Nagel 2018)	0.6	1.5	3.5	-1.7	0.2	-1.3	-0.7	-1.9	0.5
Schizophrenia (2018)	0.6	1.2	2.3	-1.1	-0.5	-1.3	-1.5	-1.3	0.1
Schizophrenia vs Biploar Disorder	2.1	2.8	4.6	-2.1	-0.3	-2.1	-1.9	-2.1	0.4
Worry (Nagel 2018)	0.3	0.6	1.3	-0.7	1.1	-0.5	0.1	-0.9	0.8
Alzheimer’s Disease (in mother)	0.6	0.7	2.3	-0.7	-1.5	-0.6	-0.6	-0.8	-0.6
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.1	-0.1	0.1	-0.4	-0.3	-0.2
Alzheimer’s Disease (including proxy)	1.3	2.0	3.7	-1.5	-0.9	-1.4	-1.7	-1.9	-0.5
Crohns Disease (2017)	0.1	0.2	0.4	0.7	0.0	0.5	-0.6	-0.1	0.6
Irritable Bowel Disease (IBD)	0.5	1.2	2.7	-1.0	0.6	-1.1	-1.6	-1.3	-0.6
Ulcerative Colitis (UC)	1.5	2.9	4.1	-1.9	1.4	-2.0	-1.7	-1.7	-1.2
Major Depression (MDD)	0.6	0.7	1.2	-0.7	-1.1	-0.6	-0.8	-0.9	0.8
Reaction Time	0.4	0.9	2.8	0.8	-1.7	1.0	0.4	0.4	-0.6
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.3	0.1	-0.6	-0.2	0.4	0.1	-0.3
Breast Cancer	1.7	4.2	8.0	-2.4	-0.8	-2.4	-2.8	-2.1	-0.5
Ovarian Cancer	0.8	1.0	1.8	-1.0	-0.5	-1.0	-1.3	-1.1	1.0
Prostate Cancer	0.4	0.5	1.3	0.6	-0.5	0.6	1.1	0.5	0.9
Age at First Birth	0.1	0.2	0.6	-0.3	0.5	-0.4	0.1	0.3	0.8
Bipolar Disorder (2011)	1.1	1.1	2.0	-1.1	0.4	-1.3	-1.2	-1.4	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.0	0.8	-1.0	0.7	0.2	0.6	-0.9
Coronary Artery Disease (CAD)	0.9	1.1	1.6	0.9	-0.9	1.1	0.9	1.3	-1.3
Crohns Disease (2012)	1.1	1.8	3.5	1.8	-0.1	1.9	1.4	1.4	-0.6
Mean Putamen Volume	0.9	1.0	2.5	-0.5	0.3	-0.9	-1.6	-1.3	0.7
Fasting Glucose	2.3	2.8	7.0	-1.0	2.3	-1.3	-0.5	-1.3	2.6
HbA1C	0.5	0.5	1.4	-0.6	0.3	-0.7	-1.2	-0.8	0.0
HDL Cholesterol	0.8	1.3	3.0	-1.7	0.6	-1.4	-1.0	-1.1	0.7
LDL Cholesterol	0.2	0.2	0.5	-0.0	-0.7	0.2	0.4	0.6	0.7
Lupus	2.2	3.4	5.7	-1.5	1.8	-1.6	-2.4	-2.1	-1.4
Neuroticism (2016)	0.2	0.3	1.4	-0.2	-0.2	0.1	-0.1	-0.5	-1.2
Primary Biliary Cirrhosis	0.2	0.3	0.6	-0.3	-0.6	-0.1	-0.8	-0.2	-0.7
Rheumatoid Arthritis	1.3	1.8	3.9	1.3	1.1	1.5	2.0	1.3	0.3
Schizophrenia (2014)	1.7	3.7	6.4	-2.1	-0.1	-2.3	-2.5	-2.4	-0.5
Triglycerides	0.4	0.7	1.0	-0.5	-0.8	-1.0	-0.9	-0.8	0.8
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.3	-1.2	1.4	-1.3	-0.5	-1.2	-1.8
Ulcerative Colitis	1.0	1.4	2.6	-1.3	1.2	-1.6	-1.2	-1.1	-0.2
Blood Eosinophil Count	0.5	3.6	4.7	1.8	-1.7	1.6	2.2	2.1	-1.9
Blood Platelet Count	0.1	1.5	4.6	-0.5	2.1	-0.5	1.5	1.0	-0.6
Blood Red Count	0.8	7.6	23.5	2.7	0.3	2.5	4.8	2.9	0.2
Blood White Count	0.3	2.3	9.0	-1.0	-3.0	-1.3	-1.4	-0.4	0.5
Heel T-Score	0.6	5.0	11.1	1.9	-2.1	1.1	3.3	1.8	2.5
BMI	0.6	3.4	13.1	-0.6	-3.6	-0.9	-1.6	-1.0	-1.6
Height	0.7	13.8	43.8	-1.1	2.4	-3.0	-6.6	-4.6	-1.5
Waist Hip Ratio (WHR)	0.2	0.9	2.1	0.1	1.5	0.4	1.4	1.0	0.2
Systolic Blood Pressure	0.6	3.2	5.5	-1.8	0.6	-2.0	-1.5	-1.9	2.3
Smoking Status	0.5	1.1	2.6	-0.9	-1.2	-0.5	-1.6	-1.3	0.4
Allergy or Eczema	0.7	1.9	4.6	1.4	2.2	0.9	1.1	1.1	1.2
Cardiovascular Disease	0.8	2.7	4.9	-1.6	-2.2	-1.6	-1.5	-1.4	-1.2
Hypothyroidism (self reported)	1.4	3.3	7.0	-1.9	1.0	-2.1	-1.8	-2.7	0.6
Respiratory disease	0.6	1.4	3.9	-0.5	2.0	-0.6	-0.9	-1.1	1.3
Type 2 Diabetes (T2D) (2018)	10.4	19.4	34.6	-5.7	0.4	-5.9	-5.4	-4.4	-0.6
Lung FEV1/FVC ratio	0.4	2.1	7.6	-0.7	2.8	-1.4	0.1	-1.6	-0.6
Lung FVC	2.0	10.2	16.8	3.3	-2.7	4.1	3.6	3.7	0.2
Neuroticism	0.1	0.2	0.5	-0.2	-0.7	0.1	0.3	-0.6	0.3
Chronotype (morning person)	0.1	0.1	0.3	0.4	-0.3	0.2	0.3	0.3	-0.5
Hair Pigment	21.1	602.3	1403.5	22.5	-13.7	25.6	37.5	25.7	-14.0
Tanning	45.6	556.8	1253.2	-21.2	13.4	-24.2	-35.4	-24.9	15.9
Hand grip strength (left)	0.1	0.4	1.3	0.1	0.7	-0.5	-0.4	-0.2	-1.1
Number of treatments/medications taken	2.4	4.3	6.6	-2.6	-1.5	-2.5	-2.2	-2.5	0.0
Average weekly spirits intake	2.1	2.6	3.7	1.9	-1.9	1.9	1.0	1.8	0.9
Sensitivity / hurt feelings	0.2	0.4	1.1	-0.3	-1.1	0.1	-0.6	-0.8	-0.3
Frequency of depressed mood in last 2 weeks	0.9	1.3	6.7	0.2	-2.6	0.4	0.1	0.1	-1.0
Hearing difficulty/problems: Yes	1.5	2.3	4.9	1.5	0.9	1.6	1.5	0.9	2.2
Relative age of first facial hair	0.2	0.5	1.1	0.5	-0.1	1.0	1.1	0.6	-0.4
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.9	1.3	-1.7	1.4	1.5	1.2	0.2
Ever used hormone-replacement therapy (HRT)	1.9	2.5	5.5	-1.6	0.3	-1.8	-1.7	-2.3	0.4
Ever had hysterectomy (womb removed)	2.9	3.3	5.9	2.3	-0.8	2.0	1.2	1.6	2.4
Systolic blood pressure, automated reading	0.6	1.7	4.2	-1.2	-0.3	-1.5	-0.7	-1.3	2.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.7	-1.0	-0.2	-1.1	-1.3	-1.0	-0.6
Angina	3.3	4.3	6.9	-2.2	-1.4	-2.4	-2.6	-2.4	0.7
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.1	0.4	-0.2	-0.4	0.1	0.2
Vitamin and mineral supplements	2.5	3.4	5.9	1.8	-0.7	2.2	2.4	2.4	-0.5
Supplements: Zinc	2.3	2.5	6.2	-1.7	-0.5	-1.9	-2.5	-1.5	-0.3
Medication: Co-codamol	0.5	0.6	1.0	0.7	-1.0	0.8	0.6	0.8	-0.8
Medication: Metformin	5.2	7.4	14.4	-3.1	-1.2	-3.4	-3.8	-2.7	-0.3
Diabetes (father)	1.9	2.4	5.5	-1.6	2.3	-1.7	-1.3	-1.1	0.9
Diabetes (mother)	0.6	0.8	1.3	-1.0	0.0	-1.1	-1.1	-1.0	0.7
Severe depression (siblings)	1.5	1.6	2.7	-1.4	1.3	-1.6	-1.4	-1.1	0.4
Pack years adult smoking proportion	0.2	0.3	0.9	-0.2	0.4	-0.4	-0.9	-0.6	0.3
Impedance of leg (right)	0.2	1.0	2.5	0.2	0.9	0.6	1.6	1.0	-0.9
Leg fat-free mass (left)	0.6	3.3	11.9	-0.4	-0.6	-1.4	-3.5	-2.2	-0.7
Trunk fat percentage	0.7	2.8	11.7	-0.6	-3.4	-0.7	-0.4	-0.3	-2.0
Hand grip strength (right)	0.3	0.9	1.9	-0.7	0.8	-1.4	-1.1	-0.6	-1.1
Townsend deprivation index at recruitment	0.3	0.5	1.3	0.3	-1.1	0.6	0.5	0.8	0.6
Current tobacco smoking	0.4	0.7	1.4	0.9	-0.9	1.2	0.9	0.7	0.4
Average weekly fortified wine intake	2.9	3.4	4.1	2.0	2.0	1.9	2.0	1.3	1.8
Maternal smoking around birth	0.7	1.0	2.6	1.5	-0.0	1.6	0.1	0.3	0.9
Fed-up feelings	1.2	2.1	5.5	-1.4	-2.3	-1.0	-1.0	-1.5	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	7.2	0.1	-2.7	0.3	-0.1	-0.1	-0.7
Relative age voice broke	0.5	0.8	2.9	-0.9	0.8	-0.6	-0.3	-0.5	-1.7
Taking other prescription medications	0.9	1.4	2.2	-1.0	-1.2	-1.0	-1.4	-1.5	-0.8
Age when periods started (menarche)	2.1	5.0	7.4	-2.7	2.2	-2.4	-1.7	-2.7	-1.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.4	-0.0	-1.2	-0.1	-0.0	0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.8	0.4	-1.3	0.0	0.5	0.0	0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-0.5	0.9	-0.4	-0.7	-0.9	-0.4
Qualifications: CSEs or equivalent	0.8	1.0	4.5	0.3	-0.5	0.6	0.6	0.7	-2.1
Serious illness, injury or assault to yourself	0.2	0.3	1.0	-0.4	-0.3	-0.4	-0.2	-0.3	-1.0
High blood pressure	1.1	3.1	7.1	-1.8	-2.7	-1.6	-1.6	-1.5	-0.8
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.7	1.0	2.4	0.7	0.5	0.9	1.7
Multivitamins +/- minerals	0.9	1.1	2.3	-0.7	0.7	-1.2	-1.5	-1.3	0.6
Stomach or abdominal pain in last month	1.1	1.4	2.4	1.0	0.5	1.3	1.1	1.6	-1.4
Supplements: Glucosamine	1.0	1.4	1.9	-0.9	-1.4	-1.4	-1.4	-1.1	0.6
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.6	-1.6	1.1	-1.6	-1.0	-1.2	-0.5
Medication: Atenolol	0.8	1.0	2.5	-0.7	-1.6	-0.6	-1.2	-0.9	-0.4
Medication: Levothyroxine sodium	1.2	2.0	3.2	-1.5	-1.3	-1.6	-1.6	-1.8	-0.2
Sitting height	1.3	9.5	27.9	-1.8	1.1	-3.3	-5.3	-3.7	-0.3
Chronic bronchitis/emphysema (father)	0.1	0.2	0.6	0.4	-0.3	0.5	-0.1	0.1	-0.8
High blood pressure (mother)	0.3	0.5	1.0	-0.3	1.0	-0.6	-0.9	-0.4	-0.6
Body mass index (BMI)	0.6	2.4	9.8	-0.6	-3.1	-0.8	-0.9	-0.6	-1.5
Impedance of leg (left)	0.1	0.4	1.0	-0.4	0.7	0.1	1.0	0.6	-0.5
Leg predicted mass (left)	0.6	3.3	11.9	-0.4	-0.6	-1.4	-3.5	-2.2	-0.6
Trunk fat mass	0.7	2.9	8.4	-0.7	-2.9	-1.1	-1.5	-0.9	-2.1
Waist circumference	0.6	2.2	5.2	-1.1	-2.3	-1.3	-1.5	-0.9	-1.5
Number of incorrect matches in round	1.3	2.2	3.3	1.6	-1.6	1.8	1.1	1.4	-1.0
Past tobacco smoking	0.5	0.9	2.0	1.1	0.5	0.6	1.4	1.2	0.1
Alcohol usually taken with meals	0.9	1.4	2.3	1.5	-0.2	1.2	1.0	1.3	1.4
Nervous feelings	0.5	0.9	2.8	0.5	0.5	0.9	1.7	1.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	2.3	1.1	-1.3	1.5	1.1	1.5	-1.1
Hearing difficulty/problems with background noise	1.0	1.5	5.7	0.9	2.4	0.9	0.7	0.4	1.1
Hair/balding pattern: Pattern 2	2.8	3.6	6.1	1.8	-1.6	2.0	2.4	2.5	0.0
Had menopause	0.2	0.3	1.2	0.1	-0.3	-0.2	-0.2	-1.1	0.5
Had other major operations	0.4	0.5	2.4	0.3	-1.5	0.3	0.4	0.1	-0.4
Forced vital capacity (FVC)	0.3	1.2	3.2	1.8	0.1	1.7	0.6	1.0	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.5	0.2	-1.2	-0.1	0.8	0.2	0.6
Ever unenthusiastic/disinterested for a whole week	3.2	3.9	5.9	2.3	-0.4	2.4	2.2	2.0	1.6
Qualifications: None of the above	0.7	1.6	6.8	-0.5	-2.6	-0.2	-1.2	-1.1	-0.1
Financial difficulties in last 2 years	0.6	0.8	2.5	-0.7	-0.5	-0.7	-1.6	-1.1	-0.2
Mouth/teeth dental problems	2.0	3.0	4.5	1.9	2.1	1.8	2.1	1.6	0.1
Heart attack	0.9	1.2	2.0	-0.9	-1.4	-1.1	-1.4	-0.9	-0.3
Allergy	1.0	2.4	9.1	0.3	-3.0	0.7	1.2	0.9	-1.6
Pain all over the body in last month	0.4	0.4	1.2	-0.7	-1.1	-0.7	-0.1	-0.6	-0.2
Diabetes (self-reported)	6.9	10.7	18.3	-4.1	-0.1	-4.2	-4.3	-3.2	-0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	0.0	0.4	-0.3	-1.0	-0.5	0.5
Medication: Ramipril	1.3	1.6	2.9	-1.7	-0.2	-1.7	-1.2	-1.5	-0.1
Medication: Simvastatin	1.4	2.1	2.9	-1.6	-1.0	-1.7	-1.7	-1.4	-1.2
Fluid intelligence score	0.1	0.3	0.7	0.2	-0.8	-0.0	0.4	0.4	-0.7
Illnesses of siblings	3.2	4.4	8.0	2.6	-0.2	2.8	2.5	2.1	0.9
Neuroticism score	0.3	0.6	1.3	0.4	-1.1	1.0	1.1	0.4	-0.1
Weight	0.9	4.4	10.4	-1.1	-2.0	-1.9	-3.2	-2.1	-1.7
Impedance of arm (right)	0.6	2.8	8.3	1.1	1.3	1.6	2.9	1.6	-0.5
Arm fat percentage (right)	0.7	2.6	10.0	-0.1	-3.2	-0.1	0.3	0.2	-2.4
Trunk fat-free mass	1.3	7.3	23.9	-1.4	0.7	-2.5	-4.9	-3.2	-0.7
Hip circumference	1.2	5.2	10.0	-1.4	-3.2	-1.8	-3.1	-1.9	-1.6
Time employed in main current job	0.1	0.1	0.3	-0.2	0.5	-0.3	-0.1	-0.2	0.4
Alcohol intake versus 10 years previously	0.9	1.4	2.3	-1.1	0.6	-1.1	-1.5	-1.5	-1.1
Father’s age at death	1.5	2.1	7.8	0.9	2.8	0.8	0.7	0.5	1.5
Worrier / anxious feelings	0.5	1.0	1.7	-1.3	1.3	-1.1	-0.7	-1.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	4.0	-0.0	-2.0	-0.1	-0.4	-0.2	-1.6
Falls in the last year	3.2	4.4	7.8	-2.5	1.2	-2.5	-2.0	-2.8	1.0
Hair/balding pattern: Pattern 3	2.3	3.5	5.7	-2.0	-0.0	-2.4	-1.7	-2.0	-2.0
Number of live births	0.2	0.2	0.5	0.4	0.5	0.3	0.6	0.7	0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.8	1.7	1.1	1.4	1.1	0.7	0.0
Pulse rate	0.2	0.4	0.6	-0.7	0.8	-0.6	-0.6	-0.0	-0.6
Happiness	0.2	0.3	0.5	-0.7	-0.4	-0.4	-0.7	-0.7	-0.2
Noisy workplace	2.2	2.8	5.1	2.0	-0.3	2.3	1.6	2.1	-0.7
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	0.1	0.5	-0.2	-0.0	0.4	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	4.2	0.2	-0.0	0.3	0.3	0.8	2.1
Mouth/teeth dental problems: Dentures	0.9	1.6	3.5	-1.0	-1.0	-1.2	-1.9	-1.4	-0.7
Asthma	0.3	0.5	2.7	-0.2	1.6	-0.2	-0.1	-0.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.6	1.2	0.1	1.1	1.3	0.8	-0.1
Medication: Cholesterol lowering	5.7	8.9	15.2	-3.9	-0.5	-3.8	-3.6	-3.2	-0.9
Depression (self-reported)	0.7	0.9	2.2	-0.2	-1.5	0.1	-1.4	-0.9	0.3
Medication: Lansoprazole	0.6	0.7	1.7	-0.8	-1.3	-0.6	-0.4	-1.0	0.4
Prospective memory result	0.5	0.6	1.2	-0.1	0.4	-0.0	-1.1	-1.1	0.9
Lung cancer (father)	2.9	3.4	18.6	-0.5	4.3	-0.7	-0.4	-0.4	0.7
Illnesses of mother	0.6	0.7	3.2	-0.5	0.3	-0.4	-0.3	-0.6	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.1	1.8	0.9	1.4	0.9	0.6	-0.1
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	0.7	-0.4	0.5	0.5	0.8	0.0
Impedance of arm (left)	0.6	2.8	8.6	1.2	0.7	1.6	2.9	1.9	-0.4
Arm fat mass (right)	0.6	2.7	8.2	-0.6	-2.9	-0.9	-1.3	-0.9	-2.0
Trunk predicted mass	1.3	7.6	24.8	-1.5	0.7	-2.6	-5.0	-3.3	-0.7
Standing height	0.8	8.1	25.4	-1.1	2.1	-2.5	-5.0	-3.4	-0.4
Length of working week for main job	0.3	0.3	1.8	-0.1	1.4	-0.2	-0.1	-0.0	0.4
Exposure to tobacco smoke at home	0.3	0.4	1.0	-0.5	-0.1	-0.4	-0.7	-0.6	-1.0
Breastfed as a baby	0.6	0.8	1.6	0.6	-1.3	0.8	0.7	0.9	0.9
Tense / ‘highly strung’	0.4	0.6	1.1	0.2	0.8	0.6	1.1	0.8	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.4	-0.2	-1.5	-0.1	-0.6	0.2	-1.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	-0.1	0.8	-0.5	0.4	-0.4	-0.4
Birth weight of first child	0.7	1.3	6.6	-0.6	0.3	-0.5	0.9	0.1	-2.6
Peak expiratory flow (PEF)	1.1	2.7	7.4	1.7	2.7	1.3	1.5	0.7	-1.1
Pulse wave reflection index	1.6	1.9	3.4	1.8	0.6	1.7	1.7	1.2	0.6
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	1.3	-0.8	1.5	1.0	1.0	0.3
Loud music exposure frequency	0.7	0.8	4.5	0.3	-2.1	0.2	-0.1	-0.2	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.2	0.6	-0.3	-0.5	-0.5	0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	3.2	-0.4	-1.8	-0.1	0.3	0.6	-0.3
Blood clot in the leg (DVT)	1.9	2.4	4.8	-1.2	0.9	-1.5	-2.1	-2.2	1.0
Medication: Paracetamol	0.2	0.4	1.2	-0.3	-1.1	-0.2	-0.0	-0.0	-0.9
Headache pain in last month	0.2	0.3	1.2	0.5	1.1	0.5	-0.0	-0.3	-0.3
Medication for cholesterol, blood pressure or diabetes	7.6	12.6	20.0	4.5	0.8	4.3	4.2	3.9	1.6
Glaucoma (self-reported)	1.9	2.3	5.1	-1.0	1.1	-1.0	-1.8	-1.5	2.3
Gout (self-reported)	0.5	0.6	1.3	1.1	-0.5	1.1	0.8	0.5	0.4
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	5.0	-1.6	-0.5	-1.8	-1.7	-2.2	0.1
Medication: Amlodipine	1.9	2.6	4.0	-2.0	0.1	-1.7	-2.0	-1.5	-1.7
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.6	1.3	0.1	1.5	1.6	1.1	-0.6
Birth weight	1.4	3.0	4.4	-1.6	2.0	-1.7	-1.3	-2.1	-1.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.5	-0.9	1.2	-0.7	-1.0	-1.0	-0.6
High blood pressure (siblings)	3.2	4.6	8.2	-2.5	0.4	-2.8	-2.9	-2.4	-0.1
Forced vital capacity (FVC), Best measure	0.3	1.0	2.8	1.7	-0.1	1.5	0.4	0.9	-0.1
Body fat percentage	0.8	3.0	13.1	-0.5	-3.6	-0.5	-0.3	-0.2	-2.1
Leg fat percentage (right)	0.8	3.0	10.6	-1.0	-3.2	-0.9	-0.7	-0.6	-2.2
Arm fat-free mass (right)	1.2	6.1	21.0	-1.3	-0.4	-2.4	-4.6	-2.8	-0.1
Exposure to tobacco smoke outside home	0.2	0.3	0.7	-0.7	-0.3	-0.6	-0.1	-0.1	-0.8
Comparative body size at age 10	0.6	1.5	5.2	0.7	-2.3	0.4	-1.1	0.0	-1.5
Number of full brothers	0.8	1.0	2.7	-0.3	1.5	-0.5	-0.5	-0.4	-1.6
Worry too long after embarrassment	0.2	0.4	0.8	-0.9	-0.9	-0.5	0.1	-0.3	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	3.4	0.9	-1.9	1.1	0.4	0.9	-0.6
Wheeze or whistling in the chest in last year	1.9	3.4	5.1	-2.3	1.4	-2.1	-2.2	-1.9	-0.7
Number of children fathered	0.3	0.4	1.5	-0.4	1.2	-0.4	-0.1	-0.5	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.8	2.7	0.0	1.6	0.1	0.5	0.5	1.1
Age at first live birth	1.1	2.0	3.5	-1.8	1.1	-1.9	-1.1	-1.1	-1.4
Pulse wave peak to peak time	0.5	0.5	0.9	-0.9	0.3	-0.8	-0.8	-0.9	-0.3
Health satisfaction	1.6	2.0	3.0	-1.6	0.4	-1.6	-1.7	-1.5	1.4
Shortness of breath walking on level ground	0.8	1.0	1.9	-1.0	-0.7	-1.0	-1.4	-1.1	0.4
Qualifications: College or University degree	1.6	4.9	8.0	-2.3	2.8	-2.7	-2.3	-1.7	0.8
Eye problems/disorders: None of the above	3.9	4.6	8.1	2.7	-0.6	2.8	2.0	2.7	-0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.1	0.6	-1.1	0.5	0.0	0.4	1.0
Emphysema/chronic bronchitis	0.3	0.4	1.1	-0.4	-0.1	-0.3	-1.1	-0.5	-0.7
Medication for pain relief, constipation, heartburn	0.3	0.5	0.8	0.9	-0.1	0.9	0.4	0.8	0.6
Neck or shoulder pain in last month	0.1	0.2	0.5	0.6	0.3	0.5	0.1	-0.1	0.7
Medication: Blood pressure	4.5	7.9	13.3	-3.6	-0.5	-3.3	-3.3	-3.1	-1.6
Angina (self-reported)	4.1	5.4	9.1	-2.5	-1.4	-2.7	-3.0	-2.7	0.5
Migraine (self-reported)	1.0	1.3	2.5	-0.9	-1.2	-0.9	-1.2	-1.6	0.8
Medication: Ibuprofen	0.2	0.2	0.5	0.5	0.3	0.3	0.7	0.1	0.5
Medication: Allopurinol	0.1	0.2	0.4	0.6	-0.2	0.6	-0.2	-0.3	0.6
Medication: Omeprazole	0.4	0.5	1.9	-0.3	1.4	-0.6	-0.3	-0.0	0.7
Medication: Seretide 50 evohaler	0.3	0.4	0.8	-0.6	-0.3	-0.4	-0.6	-0.5	-0.9
Mean time to correctly identify matches	0.3	0.5	1.4	-0.4	-0.8	-0.2	-0.5	-0.7	1.2
Heart disease (mother)	0.7	0.9	3.5	0.4	-1.0	0.4	0.6	0.5	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.9	0.0	0.9	-0.0	0.5	0.5	0.2
Whole body fat mass	0.7	3.0	9.5	-0.7	-3.1	-1.1	-1.5	-0.9	-1.9
Leg fat mass (right)	0.8	3.1	8.3	-0.8	-2.9	-1.0	-1.7	-1.1	-2.1
Arm predicted mass (right)	1.3	6.5	22.3	-1.4	-0.4	-2.5	-4.7	-2.9	-0.2
Pulse rate, automated reading	0.2	0.6	1.2	-1.1	0.9	-1.1	-0.4	0.0	-0.3
Alcohol intake frequency.	0.3	0.6	3.3	-0.1	-1.8	0.1	0.6	0.2	-0.2
Comparative height size at age 10	0.2	1.0	2.2	1.2	-0.3	0.3	-1.3	-0.3	-1.5
Number of full sisters	2.3	2.8	4.9	-2.0	-0.6	-1.8	-1.4	-1.5	-2.2
Suffer from ‘nerves’	0.1	0.1	0.4	-0.1	-0.5	0.1	0.4	-0.0	0.7
Overall health rating	0.8	1.8	3.5	-1.3	-1.1	-1.2	-1.9	-1.7	0.1
Chest pain or discomfort	0.9	1.3	2.7	-1.5	0.6	-1.7	-1.3	-0.6	-0.7
Had major operations	0.5	0.6	0.9	-0.8	0.2	-0.8	-0.9	-0.8	-0.8
Age at last live birth	1.3	1.9	3.4	-1.8	0.5	-1.8	-1.4	-1.0	-1.3
Family relationship satisfaction	0.6	0.7	2.2	-0.4	1.5	-0.4	-0.7	-1.2	-0.1
Leg pain on walking	1.2	1.5	8.5	0.6	0.4	0.5	-0.1	0.1	2.9
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.4	1.3	-0.9	1.4	1.5	1.4	-0.4
Commuting to job workplace: Car/motor vehicle	1.0	1.2	1.7	-1.0	-1.3	-1.0	-1.0	-1.0	-1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.9	-0.6	-0.6	-0.7	-0.8	-0.9	0.0
Medication: Aspirin	1.5	2.0	3.4	-1.8	-0.2	-1.8	-1.6	-1.8	0.1
Supplements: Vitamin C	1.7	2.1	3.2	-1.7	0.4	-1.8	-1.8	-1.7	-0.5
Knee pain experienced in last month	0.2	0.3	1.0	-0.4	0.6	-0.2	0.3	-1.0	0.0
Hypertension (Self-reported)	1.0	2.7	7.9	-1.6	-2.8	-1.4	-1.3	-1.1	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.3	-1.4	1.1	-1.5	-0.8	-0.9	-0.7
Illnesses of father: Heart disease	0.7	1.0	5.7	0.2	-2.4	0.2	0.2	0.6	-0.1
Illnesses of siblings: Diabetes	3.4	4.2	7.5	-2.6	-0.4	-2.7	-2.3	-2.1	-0.9
Smoking status: Previous	0.4	0.6	1.6	-0.7	-0.5	-0.4	-1.2	-1.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	7.2	-1.0	1.1	-1.5	-2.7	-1.3	-0.5
Whole body fat-free mass	1.1	6.2	21.2	-1.2	0.1	-2.3	-4.6	-3.0	-0.6
Leg fat-free mass (right)	0.7	3.9	14.4	-0.6	-0.5	-1.6	-3.8	-2.4	-0.3
Arm fat percentage (left)	0.7	2.9	11.8	0.1	-3.4	0.0	0.4	0.4	-2.3
Average weekly red wine intake	0.8	1.2	4.0	0.7	1.4	0.6	0.6	0.4	2.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.1	1.1	0.3	0.9	0.4	0.7	-1.0
Mood swings	0.6	1.2	3.8	-0.1	-1.6	0.3	-0.0	-0.6	-2.0
Loneliness, isolation	0.4	0.5	1.0	0.4	-0.9	0.8	0.6	0.6	-1.0
Long-standing illness, disability or infirmity	0.1	0.2	0.5	0.4	0.6	0.3	0.4	-0.2	0.7
Ever had bowel cancer screening	2.1	2.4	3.9	-2.0	0.5	-2.0	-1.5	-1.8	0.8
Diabetes diagnosed by doctor	9.7	15.9	27.4	-5.1	0.2	-5.2	-5.1	-4.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.1	-0.4	-0.8	-0.3	-0.4	0.1	1.1
Friendships satisfaction	0.2	0.2	0.4	-0.7	0.5	-0.5	-0.6	-0.4	0.1
Qualifications: nursing, teaching	1.2	1.8	3.2	-1.5	1.4	-1.6	-1.8	-1.0	0.4
Commuting to job workplace: Walk	1.8	2.0	6.2	1.1	2.5	1.1	1.3	0.9	0.8
Eye problems/disorders: Cataract	5.7	6.6	13.5	-3.5	1.5	-3.7	-2.3	-2.4	0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.7	-0.6	0.8	-0.5	-0.7	-0.4	0.8
Medication for cholesterol	0.5	0.8	4.1	0.3	2.0	0.4	0.2	0.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	-0.4	0.5	-0.1	-0.9	-0.0	-0.9
Back pain experienced in last month	0.1	0.2	0.4	0.3	0.6	0.4	0.1	-0.0	-0.6
Mineral and other dietary supplements	1.0	1.4	4.7	0.2	0.3	0.5	1.0	1.4	-2.2
Breast cancer (self-reported)	0.3	0.3	0.9	-0.0	-0.2	0.2	0.8	0.6	0.9
Asthma (self-reported)	0.2	0.4	2.3	-0.2	1.5	-0.2	-0.3	-0.1	0.4
Osteoporosis (self-reported)	0.3	0.4	1.0	0.5	1.0	0.5	0.5	0.5	0.4
Osteoarthritis (self-reported)	0.9	1.2	4.5	0.7	-0.6	0.7	1.1	0.5	2.1
Medication: Aspirin	0.9	1.2	2.3	-1.4	-0.1	-1.5	-1.1	-1.1	0.4
Medication: Gliclazide	3.2	3.7	5.9	-2.4	0.9	-2.4	-2.3	-1.9	-0.6
Illnesses of father: None of the above (group 1)	0.6	0.8	3.0	-0.6	1.7	-0.7	-0.1	-0.3	0.8
Smoking status: Current	0.3	0.5	1.0	0.7	-0.6	1.0	0.8	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.8	1.2	-0.2	1.3	1.9	1.6	0.0
Whole body water mass	1.1	6.2	21.4	-1.1	0.0	-2.3	-4.6	-3.0	-0.5
Leg predicted mass (right)	0.7	3.8	13.8	-0.6	-0.5	-1.6	-3.7	-2.4	-0.3
Arm fat mass (left)	0.6	2.6	8.4	-0.6	-2.9	-1.0	-1.3	-0.8	-1.9
Number of self-reported non-cancer illnesses	3.4	5.9	10.8	-3.0	0.4	-2.9	-2.7	-3.3	0.3
Average weekly champagne plus white wine intake	1.2	1.7	2.9	1.7	1.2	1.6	1.1	1.2	0.7
Miserableness	0.8	1.3	3.3	0.9	-1.8	1.3	0.9	0.9	-0.7
Guilty feelings	1.4	2.2	3.7	-1.9	0.5	-1.6	-1.8	-1.8	-0.1
Wears glasses or contact lenses	1.6	1.8	3.8	1.3	0.3	1.2	1.9	1.4	1.2
Ever taken oral contraceptive pill	1.2	1.4	2.1	-1.4	1.3	-1.2	-1.3	-1.2	0.1
Hearing aid user	0.8	0.9	1.5	1.1	0.5	1.0	1.2	0.7	0.9
Mother’s age at death	0.2	0.2	0.9	0.1	0.2	-0.0	-0.1	0.4	-1.0
Financial situation satisfaction	0.3	0.3	1.3	0.3	-0.1	0.5	-0.4	0.1	1.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	0.2	0.4	0.1	1.3	0.9	0.8
Commuting to job workplace: Public transport	0.4	0.4	1.2	0.5	0.6	0.6	0.5	1.1	-0.3
Eye problems/disorders: Glaucoma	1.2	1.4	5.9	-0.0	0.8	-0.1	-0.8	-1.0	2.4
Medication: Blood pressure	1.2	2.2	10.0	-0.8	-3.2	-0.8	-0.8	-1.1	0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.2	1.1	-0.8	1.0	0.5	0.9	0.3
Supplements: Fish oil (including cod liver oil)	1.5	2.0	5.7	-0.7	1.1	-0.9	-0.7	-1.7	2.4
High cholesterol (Self-reported)	4.3	7.6	11.8	-3.3	-1.5	-3.4	-3.4	-3.1	0.6
Medication: Bendroflumethiazide	3.1	4.8	6.9	-2.6	-2.2	-2.5	-2.0	-2.4	-0.8
Medication: Paracetamol	0.3	0.5	2.2	-0.4	-1.5	-0.5	-0.4	-0.5	-0.4
Medication: Lisinopril	3.5	4.6	7.8	-2.6	-0.5	-2.6	-2.8	-2.4	-0.3
Medication: Atorvastatin	5.2	6.4	11.1	-3.1	-0.3	-3.3	-3.3	-2.7	0.0
Illnesses of father: High blood pressure	0.4	0.5	2.8	0.1	0.6	0.2	-0.2	-0.2	-1.7
Alcohol drinker status: Never	0.6	0.8	1.8	-0.9	0.0	-0.9	-0.9	-1.3	-0.6
Ever smoked	0.1	0.1	0.3	-0.4	-0.2	0.1	-0.6	-0.4	-0.2
Basal metabolic rate	1.0	5.6	18.6	-1.1	-0.5	-2.2	-4.3	-2.8	-0.9
Leg fat percentage (left)	0.9	3.2	10.5	-1.3	-3.2	-1.2	-1.1	-0.8	-1.9
Arm fat-free mass (left)	1.2	6.1	19.8	-1.4	-0.4	-2.4	-4.5	-2.9	-0.5
Number of operations (self-reported)	1.5	2.2	3.5	-1.8	-0.4	-1.8	-1.6	-1.9	-0.6
Average weekly beer plus cider intake	2.6	3.8	7.8	-2.4	-0.5	-2.0	-2.8	-2.2	-0.1
Irritability	0.4	0.6	2.0	0.3	0.6	0.8	1.4	0.7	0.2
Risk taking	0.1	0.2	0.6	-0.4	0.1	-0.5	-0.4	-0.2	-0.8
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.5	-1.6	-0.0	-1.4	-1.0	-1.5	0.5
Fractured/broken bones in last 5 years	0.9	1.2	2.0	-1.2	0.8	-1.3	-1.2	-1.4	-0.1
Age started oral contraceptive pill	0.4	0.5	1.4	0.4	0.9	0.2	1.2	0.0	0.9
Diastolic blood pressure, automated reading	0.2	0.5	2.9	0.3	-1.7	0.1	0.1	-0.1	-0.0
Ever depressed for a whole week	0.5	0.6	1.9	0.6	0.3	0.8	0.5	0.1	1.4
Unable to work because of sickness or disability	2.5	3.2	9.0	1.4	-1.4	1.7	1.2	1.4	-3.0
Commuting to job workplace: Cycle	0.2	0.2	0.4	0.6	0.6	0.6	-0.3	-0.2	0.3
Myopia	0.8	1.1	4.8	-0.3	2.2	-0.2	-0.8	-0.2	1.1
Vascular/heart problems diagnosed by doctor	1.6	4.2	9.7	2.0	3.1	1.9	1.9	1.8	1.0
Cholesterol lowering medication	2.7	4.0	6.9	-2.0	-1.4	-2.3	-2.6	-2.4	0.5
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	-0.3	0.6	-0.6	-0.4	-0.0	0.8
Pain experienced in last month	0.1	0.2	1.0	-0.1	-1.0	-0.1	-0.1	0.5	-0.3
Supplements: Calcium	0.1	0.1	0.4	-0.1	-0.7	-0.1	-0.3	-0.0	-0.3
Basal cell carcinoma (self-reported)	4.1	4.8	9.1	2.2	-1.5	2.3	3.0	2.4	-1.3
Heart attack/myocardial infarction (self-reported)	1.1	1.5	2.8	-1.3	-0.9	-1.4	-1.7	-1.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	3.8	-1.1	1.1	-1.4	-1.9	-1.9	1.0
Heart disease (siblings)	0.2	0.2	1.0	-0.0	-1.0	-0.1	-0.1	0.1	-0.4
Alcohol drinker status: Previous	1.1	1.2	2.4	-1.4	0.1	-1.5	-1.0	-1.3	0.3
Pack years of smoking	0.1	0.2	0.6	-0.2	0.3	-0.4	-0.8	-0.4	0.2
Impedance of whole body	0.3	1.7	5.8	0.6	0.8	1.1	2.4	1.5	-0.3
Leg fat mass (left)	0.8	3.3	8.7	-0.9	-3.0	-1.3	-1.9	-1.2	-1.9
Arm predicted mass (left)	1.4	7.3	23.6	-1.6	-0.3	-2.8	-4.9	-3.1	-0.4