Hub : Genes

UBE3C

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Frontal Cortex BA9	0.223	0.0874	0.0082	0.056	NA	0.039	NA	0.085	1.4e-02	NA	3.5e-02	NA	2.9e-03
2	GTEx	Cells Transformed fibroblasts	0.101	0.0430	0.0088	0.150	NA	0.126	NA	0.146	2.6e-11	NA	1.0e-09	NA	4.8e-11
3	GTEx	Esophagus Muscularis	0.094	0.0440	0.0096	0.027	NA	0.018	NA	0.037	9.2e-03	NA	2.8e-02	NA	2.6e-03
4	TCGA	Thyroid Carcinoma	0.029	0.0180	0.0078	0.022	0.013	0.003	NA	0.015	2.7e-03	0.018	1.4e-01	NA	1.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	2.1	0.2	0.5	-1.5	-1.0
Bipolar Disorder or Schizophrenia	0.4	0.9	2.2	0.3	0.3	-1.5	-1.1
Depressed Affect (Nagel 2018)	1.1	2.3	3.5	-0.1	1.9	-1.5	-1.8
Depression (Nagel 2018)	0.3	0.5	1.4	1.2	0.6	-0.5	-0.2
Intelligence (Savage-Jansen 2018)	1.1	3.3	4.8	-1.5	-1.7	1.7	2.2
Neuroticism (Nagel 2018)	1.3	3.1	4.8	1.0	2.1	-1.4	-2.2
Schizophrenia (2018)	0.1	0.3	0.5	0.2	-0.0	-0.7	-0.7
Schizophrenia vs Biploar Disorder	1.4	1.8	3.4	0.1	-1.8	1.3	1.5
Worry (Nagel 2018)	1.8	3.7	5.4	1.7	2.3	-1.1	-2.3
Alzheimer’s Disease (in mother)	1.2	1.4	3.5	-1.9	-0.5	-1.3	-0.5
Alzheimer’s Disease (in father)	0.3	0.4	1.4	-1.2	-0.0	0.2	-0.3
Alzheimer’s Disease (including proxy)	0.9	1.2	3.7	-1.9	-0.6	-0.9	-0.4
Crohns Disease (2017)	0.8	1.7	3.8	-0.8	0.2	-1.9	-1.5
Irritable Bowel Disease (IBD)	0.9	2.2	4.3	-1.7	0.0	-2.1	-1.4
Ulcerative Colitis (UC)	1.0	2.0	4.6	-2.1	0.1	-1.6	-0.9
Major Depression (MDD)	0.7	0.8	2.8	-0.3	-0.2	-1.7	-0.5
Reaction Time	0.5	1.0	1.8	-0.4	-0.5	1.4	1.3
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.6	-1.3	-0.2	0.5	0.2
Breast Cancer	1.0	2.3	3.8	-1.0	1.8	-1.1	-1.9
Ovarian Cancer	1.1	1.5	3.5	0.3	-1.6	-1.9	0.1
Prostate Cancer	0.6	0.9	2.4	-1.6	-0.2	0.2	1.1
Age at First Birth	0.9	1.2	3.4	-1.8	0.4	-0.8	-0.9
Bipolar Disorder (2011)	0.2	0.2	0.6	0.2	0.1	-0.8	0.1
Body Mass Index (BMI) (2010)	3.4	4.6	7.8	-1.4	1.8	-2.3	-2.8
Coronary Artery Disease (CAD)	3.0	3.6	9.5	-3.1	-0.7	-1.7	-1.2
Crohns Disease (2012)	0.6	0.9	1.6	-1.2	0.1	-1.2	-0.9
Mean Putamen Volume	4.8	5.5	9.1	1.3	-2.1	2.6	3.0
Fasting Glucose	3.0	3.6	8.2	0.4	2.9	0.8	-2.3
HbA1C	2.7	2.9	6.7	-1.6	2.6	0.5	-1.5
HDL Cholesterol	0.4	0.7	1.4	0.9	-0.3	0.7	1.2
LDL Cholesterol	0.5	0.8	1.7	0.0	1.3	-0.2	-1.3
Lupus	0.1	0.2	0.7	-0.3	0.3	0.8	0.1
Neuroticism (2016)	1.1	1.5	3.0	0.2	-1.1	1.4	1.7
Primary Biliary Cirrhosis	1.4	2.1	5.6	0.5	-0.4	2.4	1.5
Rheumatoid Arthritis	0.1	0.2	0.6	0.3	-0.8	-0.1	0.1
Schizophrenia (2014)	0.2	0.4	0.7	-0.5	-0.2	-0.8	-0.8
Triglycerides	0.2	0.4	0.8	0.9	-0.1	-0.7	-0.4
Type 2 Diabetes (T2D) (2012)	4.2	4.9	11.0	-0.3	3.3	-1.2	-2.7
Ulcerative Colitis	1.0	1.4	3.8	-2.0	0.5	-0.9	-0.9
Blood Eosinophil Count	0.8	6.3	12.0	0.0	-3.5	1.5	3.3
Blood Platelet Count	0.2	1.8	6.5	0.2	2.5	0.3	-0.6
Blood Red Count	1.0	9.7	27.8	-0.7	-5.3	-0.9	3.1
Blood White Count	0.0	0.2	0.3	-0.5	-0.5	-0.3	-0.2
Heel T-Score	0.3	2.4	4.8	1.0	-1.9	0.5	2.2
BMI	0.6	3.4	8.8	0.9	0.3	-3.0	-2.0
Height	0.3	5.9	13.0	0.5	0.6	3.6	3.2
Waist Hip Ratio (WHR)	0.2	0.8	1.5	-0.2	-0.7	-1.2	-1.1
Systolic Blood Pressure	1.7	8.6	14.5	-2.9	-0.1	-3.8	-3.4
Smoking Status	0.8	2.0	3.0	-0.4	1.7	-1.3	-1.7
Allergy or Eczema	1.7	4.4	10.7	-0.0	-3.3	0.5	2.6
Cardiovascular Disease	1.8	5.9	15.2	0.6	-0.4	-3.9	-2.8
Hypothyroidism (self reported)	0.3	0.8	1.4	0.4	-0.7	1.2	1.0
Respiratory disease	1.7	3.7	9.6	-1.2	-3.1	-0.1	2.0
Type 2 Diabetes (T2D) (2018)	8.0	14.9	30.8	-0.6	4.4	-3.0	-5.5
Lung FEV1/FVC ratio	0.2	1.1	2.2	0.1	1.5	1.2	0.8
Lung FVC	0.5	2.8	6.2	0.0	-1.2	2.5	1.9
Neuroticism	1.4	3.3	7.1	0.3	2.7	-1.1	-2.2
Chronotype (morning person)	0.2	0.5	1.1	1.1	-1.0	-0.1	0.2
Hair Pigment	0.1	2.5	6.0	0.2	2.5	-0.6	-1.9
Tanning	0.0	0.6	2.0	0.2	0.4	1.4	-0.1
Hand grip strength (left)	1.8	4.6	10.6	1.0	-2.1	1.6	3.2
Number of treatments/medications taken	1.1	2.0	4.3	-0.6	0.5	-1.8	-2.1
Average weekly spirits intake	0.8	1.0	2.7	-1.6	-0.4	-1.0	-0.5
Sensitivity / hurt feelings	0.4	0.7	2.0	-0.2	1.4	-0.7	-0.6
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.5	0.5	-0.3	0.2
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.2	-0.2	0.8	0.7
Relative age of first facial hair	0.3	0.7	1.0	0.4	0.8	-1.0	-1.0
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	2.6	1.1	-1.6	1.4	1.6
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.2	-0.7	-1.2	1.8	1.7
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.2	0.2	-0.1	0.4
Systolic blood pressure, automated reading	0.9	2.6	4.6	-2.1	-0.2	-1.9	-1.5
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.7	-0.5	1.5	-0.1	-1.6
Angina	0.2	0.3	0.6	0.3	0.2	-0.8	-0.6
Medication for hormone replacement therapy	0.6	0.6	2.1	-1.5	0.4	0.2	-0.4
Vitamin and mineral supplements	0.6	0.8	2.2	-0.8	-1.5	0.3	0.6
Supplements: Zinc	0.3	0.4	0.9	-0.9	-0.3	-0.7	0.0
Medication: Co-codamol	1.6	1.9	7.6	2.8	-0.1	0.1	-0.0
Medication: Metformin	8.8	12.5	24.9	-1.4	3.9	-2.8	-5.0
Diabetes (father)	3.0	3.8	8.7	-0.2	1.0	-2.3	-3.0
Diabetes (mother)	7.2	9.1	22.8	0.6	3.2	-1.7	-4.8
Severe depression (siblings)	0.8	0.9	2.2	0.3	-0.9	1.5	0.7
Pack years adult smoking proportion	0.5	0.8	1.5	-0.2	-1.2	0.9	1.0
Impedance of leg (right)	0.5	2.3	3.5	-1.1	-1.0	1.8	1.9
Leg fat-free mass (left)	0.1	0.4	1.1	1.0	-0.1	-0.6	0.0
Trunk fat percentage	0.1	0.4	1.0	0.3	0.5	-1.0	-0.7
Hand grip strength (right)	0.3	0.8	2.2	0.5	-0.7	0.3	1.5
Townsend deprivation index at recruitment	2.5	3.5	6.6	1.3	-1.4	2.6	1.9
Current tobacco smoking	0.2	0.2	0.7	-0.9	-0.4	0.3	-0.0
Average weekly fortified wine intake	0.5	0.5	1.9	1.4	0.1	-0.2	-0.4
Maternal smoking around birth	1.0	1.5	2.6	1.2	0.6	-1.2	-1.6
Fed-up feelings	1.4	2.5	4.9	0.2	2.0	-1.0	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.9	0.2	0.4	-1.4	-1.2
Relative age voice broke	0.8	1.2	1.4	-1.2	0.9	-1.0	-1.2
Taking other prescription medications	0.5	0.7	1.2	-0.6	-0.3	-1.1	-1.1
Age when periods started (menarche)	0.3	0.6	1.4	0.4	-0.8	-1.2	-0.6
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	4.5	-0.6	-1.5	0.3	2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	0.7	-0.6	-0.1	-0.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	3.2	0.4	0.9	1.8	0.7
Qualifications: CSEs or equivalent	0.4	0.6	1.4	0.1	0.7	-0.6	-1.2
Serious illness, injury or assault to yourself	1.5	1.8	3.1	1.5	1.7	-0.4	-1.2
High blood pressure	1.6	4.6	11.8	-0.2	-2.3	-3.4	-1.1
Hayfever, allergic rhinitis or eczema	2.0	4.4	11.6	0.0	-3.4	0.4	2.4
Multivitamins +/- minerals	0.4	0.5	1.1	0.9	1.1	-0.1	-0.4
Stomach or abdominal pain in last month	0.2	0.3	0.7	0.7	0.1	-0.0	-0.8
Supplements: Glucosamine	0.4	0.5	1.5	0.5	-0.2	-1.2	-0.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.7	-0.5	1.3	-0.2	-1.1
Medication: Atenolol	0.7	0.9	1.9	-0.3	0.3	-1.4	-1.2
Medication: Levothyroxine sodium	0.6	1.1	3.2	-1.8	0.3	1.0	-0.1
Sitting height	1.0	7.0	17.0	0.4	-1.1	3.1	4.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.2	-0.2	0.5	0.7
High blood pressure (mother)	0.5	0.7	0.8	-0.8	-0.9	0.7	0.9
Body mass index (BMI)	0.5	2.0	4.5	1.2	0.3	-2.1	-1.4
Impedance of leg (left)	0.4	1.8	3.0	-1.0	-0.9	1.7	1.6
Leg predicted mass (left)	0.1	0.3	1.0	1.0	-0.0	-0.6	-0.0
Trunk fat mass	0.1	0.4	1.1	0.5	0.3	-1.0	-0.4
Waist circumference	0.3	1.0	2.8	0.2	-0.3	-1.7	-1.1
Number of incorrect matches in round	1.0	1.6	3.1	1.1	0.6	1.3	1.8
Past tobacco smoking	1.1	2.1	6.0	0.1	-2.5	0.7	1.4
Alcohol usually taken with meals	0.7	1.1	2.6	0.0	1.6	-0.4	-1.3
Nervous feelings	1.1	2.1	3.1	1.4	1.8	-0.6	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	1.8	0.8	1.2	-1.3	-1.1
Hearing difficulty/problems with background noise	0.6	1.0	2.4	-0.6	-0.5	1.5	0.9
Hair/balding pattern: Pattern 2	0.3	0.4	1.4	0.1	0.4	-0.4	-1.2
Had menopause	1.3	1.6	2.2	-1.2	-0.8	1.4	1.5
Had other major operations	0.5	0.6	1.0	-1.0	0.6	-0.8	-0.5
Forced vital capacity (FVC)	1.1	4.1	6.1	1.6	-2.0	1.9	2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	0.8	-0.2	-0.6	-0.5
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	8.8	-0.8	-1.1	-3.0	-1.2
Qualifications: None of the above	1.6	3.3	4.3	1.8	-1.4	2.1	1.9
Financial difficulties in last 2 years	0.7	1.0	2.5	1.6	0.1	-0.7	-1.0
Mouth/teeth dental problems	0.1	0.2	0.6	-0.4	-0.0	0.1	0.8
Heart attack	2.6	3.3	7.6	-0.6	2.8	-0.6	-2.2
Allergy	1.4	3.3	8.0	0.4	2.8	-0.3	-2.2
Pain all over the body in last month	0.3	0.4	0.6	0.4	-0.8	-0.8	0.3
Diabetes (self-reported)	9.1	14.1	26.0	-1.4	3.6	-3.9	-5.1
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	5.1	0.0	-2.3	-1.4	-0.5
Medication: Ramipril	0.6	0.7	1.9	-0.3	1.4	-0.2	-0.9
Medication: Simvastatin	4.1	6.0	11.9	-0.1	3.3	-1.2	-3.4
Fluid intelligence score	0.6	1.3	4.9	-2.2	0.1	0.5	-0.3
Illnesses of siblings	0.2	0.3	0.8	0.3	0.6	0.9	-0.3
Neuroticism score	0.9	1.9	3.0	0.5	1.6	-1.4	-1.7
Weight	0.1	0.4	0.8	0.8	-0.3	-0.9	0.2
Impedance of arm (right)	0.3	1.6	4.6	-0.9	0.5	2.1	0.9
Arm fat percentage (right)	0.2	0.9	1.9	0.5	0.5	-1.4	-1.0
Trunk fat-free mass	0.3	1.5	3.5	1.2	-0.9	0.5	1.9
Hip circumference	0.1	0.3	0.9	1.0	-0.1	-0.5	0.3
Time employed in main current job	0.8	0.9	1.3	-1.0	1.0	-0.7	-1.1
Alcohol intake versus 10 years previously	0.2	0.3	1.0	0.2	0.4	-0.4	-1.0
Father’s age at death	0.2	0.2	0.6	0.1	0.1	0.8	0.6
Worrier / anxious feelings	0.5	1.0	2.3	1.5	1.1	0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.7	1.3	-1.0	0.5	0.6
Falls in the last year	2.0	2.8	4.3	2.0	0.6	-1.5	-2.1
Hair/balding pattern: Pattern 3	1.0	1.4	2.3	-1.5	-1.3	-1.2	-0.1
Number of live births	0.2	0.3	0.6	-0.6	-0.6	-0.8	-0.0
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	6.2	1.9	-1.5	2.0	2.5
Pulse rate	0.4	0.7	2.0	-1.4	0.9	-0.4	-0.2
Happiness	0.8	1.0	2.0	-1.4	1.0	-0.4	-0.9
Noisy workplace	0.6	0.8	1.8	1.3	-0.2	1.0	0.3
Qualifications: A levels/AS levels or equivalent	1.0	2.1	3.8	-1.9	-1.5	0.3	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.8	0.1	-0.3	1.7	1.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	-0.4	-0.1	0.8	0.3
Asthma	1.8	3.5	9.4	-1.6	-3.1	-0.9	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	3.6	-0.5	-1.2	1.3	1.9
Medication: Cholesterol lowering	0.8	1.3	3.5	0.6	1.9	0.9	-0.7
Depression (self-reported)	1.4	1.6	4.2	0.0	-2.0	0.4	1.5
Medication: Lansoprazole	0.3	0.3	0.5	0.4	0.4	-0.7	-0.6
Prospective memory result	1.1	1.3	1.8	1.3	1.3	-0.3	-1.3
Lung cancer (father)	3.2	3.7	10.1	-0.7	-3.2	0.5	2.0
Illnesses of mother	1.0	1.2	2.2	1.1	0.1	1.2	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.5	0.9	-0.8	1.6	1.9
Pulse wave Arterial Stiffness index	1.2	1.4	3.2	0.7	1.4	1.8	0.4
Impedance of arm (left)	0.2	1.0	2.1	-1.5	0.5	1.3	0.4
Arm fat mass (right)	0.2	0.9	1.7	0.9	0.4	-1.3	-0.8
Trunk predicted mass	0.3	1.6	3.8	1.2	-1.0	0.5	2.0
Standing height	0.4	4.1	9.5	-0.6	-1.0	2.3	3.1
Length of working week for main job	0.8	0.8	2.0	0.1	-0.3	-1.1	-1.4
Exposure to tobacco smoke at home	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.0
Breastfed as a baby	3.2	4.0	6.7	-0.6	-1.8	2.4	2.6
Tense / ‘highly strung’	0.6	1.1	2.3	1.3	1.5	-0.0	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-1.0	-0.1	-0.6	-0.0
Hair/balding pattern: Pattern 4	0.2	0.4	1.2	-0.0	1.1	-0.1	-0.7
Birth weight of first child	0.2	0.3	0.8	0.9	-0.3	0.4	0.5
Peak expiratory flow (PEF)	1.6	3.7	7.1	1.2	-1.6	1.9	2.7
Pulse wave reflection index	0.5	0.6	1.8	0.0	-0.0	1.3	0.7
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.1	1.0	0.7	-0.1	0.4
Loud music exposure frequency	0.3	0.3	0.9	1.0	0.0	0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	3.2	-1.8	-0.6	-0.3	0.2
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.6	1.0	0.3	-1.6	-1.6
Blood clot in the leg (DVT)	0.7	0.9	2.8	-0.5	1.7	0.4	-0.7
Medication: Paracetamol	0.1	0.1	0.2	0.3	-0.1	0.4	-0.5
Headache pain in last month	1.0	1.6	4.8	2.2	0.4	1.2	-0.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.5	0.2	-1.2	1.0	1.2
Glaucoma (self-reported)	0.1	0.2	0.3	-0.5	-0.1	-0.5	-0.3
Gout (self-reported)	0.6	0.9	2.2	0.2	0.2	1.5	1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.4	-0.8	-0.2	1.2	0.8
Medication: Amlodipine	0.4	0.5	1.1	-0.8	-0.1	-1.1	-0.6
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.1	-1.0	-0.6	1.5	1.2
Birth weight	2.7	5.9	8.6	2.1	-1.7	2.8	2.9
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.9	-0.2	0.2	-0.2	-0.9
High blood pressure (siblings)	0.9	1.3	2.7	0.4	-1.6	-0.7	1.3
Forced vital capacity (FVC), Best measure	0.6	2.3	4.2	0.8	-1.5	1.5	2.0
Body fat percentage	0.1	0.5	1.3	0.5	0.2	-1.2	-0.6
Leg fat percentage (right)	0.1	0.5	1.4	0.6	-0.5	-1.2	0.1
Arm fat-free mass (right)	0.3	1.3	2.5	1.2	-1.2	-0.1	1.6
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.0	0.1	0.5	-0.3
Comparative body size at age 10	1.7	4.6	9.8	0.4	0.6	-3.1	-2.8
Number of full brothers	1.3	1.7	2.7	0.9	-1.5	1.0	1.7
Worry too long after embarrassment	1.6	2.7	5.8	-0.4	1.5	-1.5	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.5	-0.6	-0.6	0.4
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	-0.5	-0.4	0.8	0.5
Number of children fathered	0.2	0.2	0.6	0.2	-0.4	0.3	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	5.0	2.2	1.3	0.7	-0.4
Age at first live birth	0.2	0.4	1.1	0.3	-1.1	-0.7	0.2
Pulse wave peak to peak time	1.7	1.9	4.2	-0.8	-1.7	-2.1	-0.4
Health satisfaction	1.3	1.7	3.4	0.1	1.0	-1.5	-1.9
Shortness of breath walking on level ground	1.9	2.3	4.4	-1.0	1.3	-1.5	-2.1
Qualifications: College or University degree	0.1	0.3	0.5	-0.7	-0.2	-0.6	-0.4
Eye problems/disorders: None of the above	0.2	0.3	0.5	0.3	0.0	-0.7	-0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.0	0.1	-1.0	0.5	0.2
Emphysema/chronic bronchitis	0.1	0.2	0.4	0.3	0.4	0.6	0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	-0.6	-0.1	0.2	0.7
Neck or shoulder pain in last month	0.5	0.8	1.5	-0.7	1.0	-0.3	-1.2
Medication: Blood pressure	0.7	1.3	2.5	-0.7	0.9	-1.6	-1.1
Angina (self-reported)	0.4	0.6	1.1	0.2	0.3	-1.1	-1.0
Migraine (self-reported)	1.2	1.5	2.6	0.1	0.9	-1.6	-1.6
Medication: Ibuprofen	0.7	0.8	1.6	-0.5	-0.1	1.3	1.1
Medication: Allopurinol	0.5	0.7	1.5	-1.2	0.7	0.9	0.4
Medication: Omeprazole	0.4	0.4	1.1	0.6	1.0	0.0	-0.6
Medication: Seretide 50 evohaler	0.6	0.7	2.0	0.5	-1.4	-0.3	0.6
Mean time to correctly identify matches	0.3	0.6	1.3	-0.8	0.3	1.1	0.7
Heart disease (mother)	0.8	1.0	2.0	0.1	-1.4	-1.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.2	0.4	-0.4	-0.6
Whole body fat mass	0.1	0.5	0.9	0.9	0.1	-1.0	-0.4
Leg fat mass (right)	0.2	0.7	1.7	0.9	-0.1	-1.3	-0.4
Arm predicted mass (right)	0.3	1.4	2.4	1.1	-1.4	-0.2	1.6
Pulse rate, automated reading	0.1	0.5	1.2	-1.1	0.2	-0.1	0.8
Alcohol intake frequency.	0.3	0.6	1.2	-0.3	0.5	1.1	1.0
Comparative height size at age 10	0.0	0.2	0.6	-0.2	-0.1	0.5	0.8
Number of full sisters	0.0	0.1	0.1	-0.2	-0.1	-0.2	0.4
Suffer from ‘nerves’	1.2	2.0	4.4	2.1	0.5	-1.0	-1.5
Overall health rating	0.4	0.9	2.1	-0.2	0.2	-1.2	-1.5
Chest pain or discomfort	0.5	0.7	1.3	-0.8	-0.6	-1.2	-0.8
Had major operations	0.5	0.5	1.3	-0.5	1.1	0.8	0.1
Age at last live birth	1.0	1.4	2.7	-0.9	-1.4	-1.6	0.1
Family relationship satisfaction	0.8	1.0	2.1	-1.5	-1.1	-0.8	-0.0
Leg pain on walking	2.0	2.5	4.8	-0.5	1.7	-1.5	-2.2
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	4.8	-0.7	0.3	-2.2	-2.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.5	1.2	1.2	-0.4	-0.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.0	-1.4	-1.3	-0.2	0.8
Medication: Aspirin	1.3	1.7	3.2	0.5	0.3	-1.8	-1.8
Supplements: Vitamin C	0.1	0.1	0.2	-0.3	0.3	-0.4	-0.3
Knee pain experienced in last month	1.3	2.1	3.9	1.0	1.0	-1.6	-2.0
Hypertension (Self-reported)	1.5	4.2	11.2	-0.4	-1.9	-3.3	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	-1.0	-0.7	-1.2	-0.4
Illnesses of father: Heart disease	0.8	1.2	2.0	-0.1	0.8	-1.4	-1.4
Illnesses of siblings: Diabetes	2.6	3.2	5.3	-1.1	2.0	-1.6	-2.3
Smoking status: Previous	1.3	1.9	5.6	0.3	2.4	-0.5	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.3	-0.0	-0.2	-1.2	-0.3
Whole body fat-free mass	0.1	0.7	1.3	1.1	-0.7	-0.1	1.2
Leg fat-free mass (right)	0.1	0.5	1.0	1.0	0.1	-0.9	-0.4
Arm fat percentage (left)	0.3	1.3	3.2	0.2	0.5	-1.8	-1.2
Average weekly red wine intake	1.2	1.8	3.6	-0.5	1.9	-0.0	-1.8
Handedness (chirality/laterality): Left-handed	1.4	1.7	5.9	-2.4	0.5	0.6	0.6
Mood swings	0.7	1.2	2.0	0.2	1.1	-1.2	-1.4
Loneliness, isolation	0.2	0.3	0.9	0.3	-0.3	-1.0	-0.0
Long-standing illness, disability or infirmity	0.3	0.4	1.1	-0.6	-1.1	-0.3	0.4
Ever had bowel cancer screening	2.5	2.9	7.7	0.2	2.8	1.3	-1.5
Diabetes diagnosed by doctor	9.3	15.3	29.3	-1.6	3.7	-4.0	-5.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.6	0.6	0.7	0.8	0.0
Friendships satisfaction	0.9	1.1	2.2	-1.5	-0.4	-1.2	-0.8
Qualifications: nursing, teaching	1.0	1.5	3.5	-1.1	-1.0	0.6	1.9
Commuting to job workplace: Walk	0.2	0.2	0.6	-0.3	-0.7	-0.0	-0.3
Eye problems/disorders: Cataract	0.5	0.5	1.0	-0.3	0.1	1.0	1.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.2	0.1	0.8	1.1	-0.1
Medication for cholesterol	1.8	2.7	6.7	-0.2	-0.4	2.0	2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.1	1.8	-0.5	1.0	1.0
Back pain experienced in last month	0.6	0.9	2.2	1.5	-0.8	0.7	0.2
Mineral and other dietary supplements	0.5	0.6	1.1	-0.6	-0.6	1.1	0.8
Breast cancer (self-reported)	1.2	1.4	2.9	0.7	-0.7	1.3	1.7
Asthma (self-reported)	1.4	2.8	8.5	-1.0	-2.9	-0.6	1.2
Osteoporosis (self-reported)	0.7	0.8	1.9	1.4	0.8	-0.5	-0.7
Osteoarthritis (self-reported)	1.1	1.4	2.9	1.5	-0.3	1.7	0.7
Medication: Aspirin	0.7	0.9	1.5	0.9	0.6	-0.9	-1.2
Medication: Gliclazide	5.8	6.5	16.2	0.4	2.6	-1.7	-4.0
Illnesses of father: None of the above (group 1)	0.8	1.0	1.8	-1.4	-0.2	1.3	0.7
Smoking status: Current	0.0	0.1	0.2	-0.3	-0.0	0.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.3	0.2	0.3	2.1	1.2
Whole body water mass	0.1	0.7	1.1	1.0	-0.7	-0.2	1.1
Leg predicted mass (right)	0.1	0.5	1.0	1.0	0.0	-0.9	-0.3
Arm fat mass (left)	0.2	1.0	2.6	0.6	0.3	-1.6	-0.9
Number of self-reported non-cancer illnesses	0.6	1.1	2.1	-0.1	-1.4	-1.4	-0.6
Average weekly champagne plus white wine intake	0.8	1.1	3.5	1.9	0.3	0.7	0.6
Miserableness	0.3	0.5	1.4	-0.3	-0.8	-1.2	-0.0
Guilty feelings	0.2	0.3	0.8	0.3	-0.1	-0.9	-0.5
Wears glasses or contact lenses	0.4	0.5	0.8	0.6	0.8	0.9	-0.1
Ever taken oral contraceptive pill	0.5	0.6	0.8	0.9	-0.9	0.4	0.8
Hearing aid user	0.9	1.0	1.7	-0.8	0.1	1.3	1.3
Mother’s age at death	0.3	0.3	0.6	-0.1	-0.8	0.5	0.6
Financial situation satisfaction	0.3	0.4	1.0	1.0	0.7	-0.0	-0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	-0.5	1.2	0.1	-0.7
Commuting to job workplace: Public transport	0.8	1.0	1.9	-0.3	-1.4	0.4	1.4
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	-0.3	-0.2	0.7	0.8
Medication: Blood pressure	0.8	1.5	3.8	0.4	-0.4	-1.4	-1.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.3	-0.2	-1.1	0.6	0.7
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.2	0.8	0.8	-1.5	-1.2
High cholesterol (Self-reported)	1.9	3.5	7.1	0.8	1.3	-2.1	-2.7
Medication: Bendroflumethiazide	0.2	0.4	0.9	0.9	-0.3	-0.0	0.7
Medication: Paracetamol	0.2	0.3	0.6	0.3	-0.7	0.8	0.2
Medication: Lisinopril	1.3	1.7	3.5	-0.9	0.8	-1.9	-1.4
Medication: Atorvastatin	0.1	0.1	0.2	0.5	0.1	0.1	-0.2
Illnesses of father: High blood pressure	1.7	2.0	6.3	-0.5	-1.0	-2.5	-0.9
Alcohol drinker status: Never	1.2	1.5	2.0	-1.3	0.6	1.3	1.4
Ever smoked	0.6	1.0	2.2	-1.0	1.5	-0.7	-0.5
Basal metabolic rate	0.1	0.6	1.2	1.1	-0.5	-0.3	0.8
Leg fat percentage (left)	0.2	0.6	1.7	0.6	-0.4	-1.3	-0.2
Arm fat-free mass (left)	0.3	1.3	2.6	1.1	-1.2	0.0	1.6
Number of operations (self-reported)	0.1	0.2	0.4	-0.6	0.6	-0.3	-0.1
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.8	-0.5	-0.8	-0.3
Irritability	0.6	1.0	3.0	0.0	1.7	0.9	0.3
Risk taking	0.2	0.2	0.7	-0.8	-0.4	-0.1	0.3
Ever had prostate specific antigen (PSA) test	4.0	4.6	8.8	-1.1	3.0	-1.2	-2.7
Fractured/broken bones in last 5 years	0.3	0.4	0.6	0.8	-0.3	0.6	0.7
Age started oral contraceptive pill	0.3	0.3	0.8	-0.3	-0.9	-0.2	0.6
Diastolic blood pressure, automated reading	0.2	0.6	1.0	-1.0	-0.9	-0.7	0.1
Ever depressed for a whole week	1.6	2.0	3.4	-1.8	-1.8	-1.2	0.2
Unable to work because of sickness or disability	0.1	0.2	0.4	0.6	-0.3	0.3	-0.1
Commuting to job workplace: Cycle	0.5	0.6	1.3	-0.4	-0.8	0.1	1.1
Myopia	1.2	1.7	3.4	1.8	1.3	0.1	-1.2
Vascular/heart problems diagnosed by doctor	1.6	4.5	11.6	0.2	2.1	3.4	1.4
Cholesterol lowering medication	5.2	7.6	17.3	0.3	1.9	-3.1	-4.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.1	0.6	1.8	0.9	-0.3
Pain experienced in last month	0.4	0.6	1.1	-1.1	0.8	0.6	0.4
Supplements: Calcium	0.5	0.5	1.2	-0.1	1.1	-0.3	-0.9
Basal cell carcinoma (self-reported)	0.7	0.8	2.2	-0.9	-1.5	-0.0	0.4
Heart attack/myocardial infarction (self-reported)	1.9	2.5	6.4	-0.6	2.5	-0.4	-1.8
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	3.1	-1.0	1.8	0.3	-0.8
Heart disease (siblings)	0.4	0.5	1.4	-0.1	0.1	-1.2	-0.6
Alcohol drinker status: Previous	0.8	0.9	2.2	0.2	1.5	0.1	-1.1
Pack years of smoking	0.6	0.8	1.3	-0.6	-1.1	0.9	0.9
Impedance of whole body	0.3	1.3	2.5	-1.3	-0.0	1.6	0.9
Leg fat mass (left)	0.2	0.7	1.6	0.9	-0.2	-1.3	-0.4
Arm predicted mass (left)	0.2	0.9	1.6	1.0	-1.0	-0.2	1.3