Hub : Traits :

Miserableness

628 significantly associated models · 94 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 23453834 24924438 1 1 2.5e-09 6.9e-10 1.0e+00 100 UBXN2A
2 3 48335857 51043528 27 7 3.3e-15 1.0e-10 NaN NaN GPX1 MST1R NICN1 RBM6 RNF123
3 7 1580921 2977732 1 1 6.4e-09 4.8e-11 3.9e-05 61 FTSJ2
4 7 11553163 12967449 1 1 4.5e-08 2.1e-08 1.0e+00 100 TMEM106B
5 8 8092025 12966739 23 1 6.8e-12 1.6e-11 3.6e-03 81 ERI1
6 9 95502571 96898436 1 1 5.0e-08 9.1e-08 1.0e+00 100 RP11-165J3.6
7 11 46010847 48559571 13 7 1.5e-14 9.2e-13 NaN NaN ARFGAP2 ARHGAP1 DDB2 FNBP4 MADD NR1H3
8 11 112135760 113952419 2 1 2.5e-08 1.8e-12 1.7e-07 45 TTC12
9 12 109231851 110605559 1 1 3.6e-07 2.3e-07 3.6e-02 84 KCTD10
10 13 31078511 32595740 1 1 1.4e-07 5.1e-06 3.1e-01 95 B3GALTL
11 15 77207277 78806023 1 1 3.3e-07 3.8e-10 2.2e-05 54 LINGO1
12 17 1805677 3287175 1 1 8.7e-09 5.8e-12 1.3e-04 69 PAFAH1B1
13 17 15214608 16908991 2 1 2.1e-08 4.3e-08 1.7e-01 94 PIGL
14 17 42774693 45796313 18 1 4.3e-11 3.3e-09 7.7e-01 100 MAPT
15 18 52209411 54028036 1 1 1.4e-07 1.5e-07 1.5e-01 92 TCF4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 2.06 1 0 0.0 0.00 1.0e+00 MADD
Crohns Disease (2017) 3.83 4 3 9.1 -0.99 6.8e-04 GPX1 MST1R NICN1 RBM6
Irritable Bowel Disease (IBD) 5.99 5 5 15.2 -0.99 2.5e-04 GPX1 MST1R NICN1 RBM6 RNF123
Ulcerative Colitis (UC) 5.86 4 4 12.1 -0.99 1.8e-03 GPX1 NICN1 RBM6 RNF123
Major Depression (MDD) 5.46 4 0 0.0 -0.98 1.7e-02 GPX1 RNF123 TCF4 TMEM106B
Reaction Time 3.68 3 2 6.1 1.00 2.1e-03 ARFGAP2 ARHGAP1 DDB2
Verbal and Numeric Reasoning (VNR) 5.28 6 5 15.2 0.99 6.1e-06 GPX1 MAPT MST1R NICN1 RBM6 RNF123
Breast Cancer 2.52 2 1 3.0 0.00 1.0e+00 MAPT NR1H3
Ovarian Cancer 1.62 1 1 3.0 0.00 1.0e+00 MAPT
Prostate Cancer 4.08 1 0 0.0 0.00 1.0e+00 GPX1
Age at First Birth 6.93 5 4 12.1 0.99 5.1e-05 GPX1 MST1R NICN1 RBM6 RNF123
Body Mass Index (BMI) (2010) 2.97 2 1 3.0 0.00 1.0e+00 FNBP4 MADD
Crohns Disease (2012) 2.97 3 1 3.0 0.99 6.0e-03 MST1R NICN1 RBM6
Fasting Glucose 5.06 3 2 6.1 0.00 1.0e+00 FNBP4 MADD NR1H3
HDL Cholesterol 4.31 7 1 3.0 0.77 2.6e-02 ARFGAP2 ARHGAP1 DDB2 KCTD10 MST1R NR1H3 RBM6
Lupus 1.36 1 0 0.0 0.00 1.0e+00 ERI1
Neuroticism 9.57 6 2 6.1 -0.98 8.7e-04 ERI1 FNBP4 GPX1 MADD MAPT TCF4
Ulcerative Colitis 5.10 3 2 6.1 0.98 2.1e-02 GPX1 NICN1 RBM6
Blood Eosinophil Count 1.40 5 3 9.1 0.21 7.3e-01 GPX1 MAPT MST1R NICN1 RBM6
Blood Platelet Count 0.83 4 3 9.1 0.10 9.0e-01 ARFGAP2 FNBP4 MADD UBXN2A
Blood Red Count 2.59 4 4 12.1 -0.83 1.7e-01 GPX1 MAPT MST1R UBXN2A
Blood White Count 2.83 9 6 18.2 -0.47 1.7e-01 GPX1 MADD MAPT MST1R NICN1 PIGL RBM6 RNF123 UBXN2A
Heel T-Score 6.86 10 9 27.3 0.61 4.6e-02 ARFGAP2 ARHGAP1 B3GALTL DDB2 GPX1 MADD MAPT MST1R NR1H3 RBM6
BMI 6.17 9 8 24.2 -0.50 1.2e-01 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123 TTC12
Height 1.37 13 11 33.3 0.45 1.2e-01 ARFGAP2 DDB2 FNBP4 FTSJ2 GPX1 MADD MAPT NICN1 PAFAH1B1 RP11-165J3.6 TCF4 TMEM106B UBXN2A
Waist Hip Ratio (WHR) 2.15 4 3 9.1 0.52 2.9e-01 GPX1 MAPT NICN1 UBXN2A
Systolic Blood Pressure 5.16 11 8 24.2 -0.78 2.8e-03 ARFGAP2 ARHGAP1 DDB2 FNBP4 GPX1 KCTD10 MADD MAPT NR1H3 PAFAH1B1 RNF123
Smoking Status 3.36 4 2 6.1 -0.75 8.6e-02 GPX1 MAPT NICN1 RNF123
Cardiovascular Disease 2.38 3 1 3.0 0.00 1.0e+00 FTSJ2 NR1H3 TTC12
Respiratory disease 1.93 3 0 0.0 0.00 1.0e+00 MST1R RBM6 RNF123
Type 2 Diabetes (T2D) 2.54 4 0 0.0 -0.60 4.0e-01 FNBP4 MST1R RBM6 RNF123
Lung FEV1/FVC ratio 0.97 3 1 3.0 0.00 1.0e+00 GPX1 MAPT RNF123
Lung FVC 3.34 7 4 12.1 0.89 3.1e-03 GPX1 MAPT NICN1 RBM6 RNF123 TCF4 UBXN2A
Neuroticism 12.34 22 17 51.5 -0.98 2.2e-15 ARFGAP2 ARHGAP1 B3GALTL DDB2 FNBP4 FTSJ2 GPX1 KCTD10 LINGO1 MADD MAPT MST1R NICN1 NR1H3 PAFAH1B1 RBM6 RNF123 RP11-165J3.6 TCF4 TMEM106B TTC12 UBXN2A
Chronotype (morning person) 2.48 2 0 0.0 0.00 1.0e+00 RBM6 UBXN2A
Hair Pigment 0.15 2 0 0.0 0.00 1.0e+00 ARFGAP2 DDB2
Hand grip strength (left) 3.42 6 4 12.1 -0.22 6.7e-01 FNBP4 LINGO1 MADD MAPT TCF4 UBXN2A
Number of treatments/medications taken 5.97 6 3 9.1 0.98 8.8e-04 B3GALTL FTSJ2 GPX1 MST1R RBM6 RNF123
Sensitivity / hurt feelings 5.72 4 3 9.1 0.61 3.9e-01 ERI1 MAPT RP11-165J3.6 TTC12
Frequency of depressed mood in last 2 weeks 8.52 9 1 3.0 0.99 3.3e-07 ERI1 FNBP4 MADD MAPT PAFAH1B1 RP11-165J3.6 TMEM106B TTC12 UBXN2A
Relative age of first facial hair 2.85 2 1 3.0 0.00 1.0e+00 GPX1 MAPT
Systolic blood pressure, automated reading 4.28 8 5 15.2 0.52 1.8e-01 DDB2 ERI1 FNBP4 GPX1 MADD MAPT NR1H3 PAFAH1B1
Medication: Co-codamol 3.97 2 0 0.0 0.00 1.0e+00 RBM6 RNF123
Medication: Metformin 2.71 1 1 3.0 0.00 1.0e+00 FNBP4
Pack years adult smoking proportion 3.11 2 0 0.0 0.00 1.0e+00 GPX1 NICN1
Impedance of leg (right) 3.49 8 7 21.2 -0.01 9.8e-01 ERI1 FNBP4 GPX1 MADD NICN1 RBM6 RNF123 UBXN2A
Leg fat-free mass (left) 3.11 8 5 15.2 0.16 6.8e-01 ARFGAP2 ERI1 FNBP4 GPX1 MST1R RBM6 RNF123 UBXN2A
Trunk fat percentage 4.77 8 6 18.2 -0.05 9.0e-01 FNBP4 FTSJ2 GPX1 MADD MAPT MST1R RBM6 RNF123
Hand grip strength (right) 2.66 5 2 6.1 -0.23 7.1e-01 FNBP4 LINGO1 MADD MAPT TCF4
Current tobacco smoking 3.14 1 0 0.0 0.00 1.0e+00 UBXN2A
Fed-up feelings 12.64 17 9 27.3 0.99 8.5e-16 ARFGAP2 ARHGAP1 B3GALTL DDB2 ERI1 GPX1 LINGO1 MADD MAPT MST1R NICN1 NR1H3 PAFAH1B1 RBM6 RNF123 TTC12 UBXN2A
Frequency of unenthusiasm / disinterest in last 2 weeks 7.23 2 0 0.0 0.00 1.0e+00 TTC12 UBXN2A
Relative age voice broke 2.09 1 1 3.0 0.00 1.0e+00 MAPT
Taking other prescription medications 6.80 6 3 9.1 0.98 8.5e-04 B3GALTL GPX1 MST1R NICN1 RBM6 RNF123
Age when periods started (menarche) 4.88 6 3 9.1 0.98 1.9e-05 FNBP4 GPX1 MADD NICN1 RBM6 RNF123
Heel bone mineral density (BMD) T-score, automated (left) 6.51 6 5 15.2 -0.57 1.9e-01 ARFGAP2 ARHGAP1 DDB2 ERI1 MST1R RBM6
High blood pressure 4.57 7 4 12.1 0.63 9.7e-02 ARFGAP2 ARHGAP1 DDB2 ERI1 FNBP4 MADD NR1H3
Medication: Levothyroxine sodium 1.21 1 0 0.0 0.00 1.0e+00 ERI1
Sitting height 2.54 7 5 15.2 -0.56 1.9e-01 ARFGAP2 DDB2 ERI1 FNBP4 MADD MAPT UBXN2A
Body mass index (BMI) 7.39 9 9 27.3 0.39 2.4e-01 ERI1 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123
Impedance of leg (left) 3.70 10 6 18.2 -0.19 5.5e-01 ERI1 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123 UBXN2A
Leg predicted mass (left) 3.08 8 5 15.2 0.16 6.9e-01 ARFGAP2 ERI1 FNBP4 GPX1 MST1R RBM6 RNF123 UBXN2A
Trunk fat mass 4.64 7 5 15.2 0.09 8.4e-01 FNBP4 GPX1 MADD MAPT MST1R RBM6 RNF123
Waist circumference 4.33 6 5 15.2 0.37 4.7e-01 FNBP4 FTSJ2 MADD MST1R RBM6 RNF123
Past tobacco smoking 1.75 1 0 0.0 0.00 1.0e+00 GPX1
Nervous feelings 5.82 6 3 9.1 0.99 5.3e-05 B3GALTL ERI1 LINGO1 MADD MAPT NR1H3
Frequency of tenseness / restlessness in last 2 weeks 9.35 10 2 6.1 0.98 4.4e-08 B3GALTL GPX1 MADD MAPT NICN1 RBM6 RNF123 RP11-165J3.6 TMEM106B TTC12
Hearing difficulty/problems with background noise 4.37 5 0 0.0 1.00 1.8e-05 ARFGAP2 ARHGAP1 DDB2 MAPT PAFAH1B1
Hair/balding pattern: Pattern 2 1.98 1 0 0.0 0.00 1.0e+00 MAPT
Forced vital capacity (FVC) 3.55 8 2 6.1 -0.77 2.4e-02 ARFGAP2 DDB2 FNBP4 GPX1 MAPT NICN1 RNF123 UBXN2A
Heel bone mineral density (BMD) T-score, automated (right) 6.95 8 4 12.1 -0.63 6.7e-02 ARFGAP2 ARHGAP1 DDB2 ERI1 GPX1 MST1R NR1H3 RBM6
Ever unenthusiastic/disinterested for a whole week 4.89 3 0 0.0 0.00 1.0e+00 GPX1 MAPT RNF123
Qualifications: None of the above 5.97 6 4 12.1 1.00 7.1e-08 B3GALTL GPX1 MST1R NICN1 RBM6 RNF123
Pain all over the body in last month 4.81 1 0 0.0 0.00 1.0e+00 NICN1
Diabetes (self-reported) 2.78 3 1 3.0 0.00 1.0e+00 MST1R RBM6 RNF123
Fluid intelligence score 4.95 7 3 9.1 -0.72 6.6e-02 GPX1 MADD MAPT MST1R NICN1 RBM6 RNF123
Neuroticism score 13.80 21 13 39.4 0.98 7.4e-15 ARHGAP1 B3GALTL DDB2 ERI1 FNBP4 FTSJ2 GPX1 KCTD10 LINGO1 MADD MAPT MST1R NR1H3 PAFAH1B1 RBM6 RNF123 RP11-165J3.6 TCF4 TMEM106B TTC12 UBXN2A
Weight 4.27 8 6 18.2 0.39 3.1e-01 ERI1 FNBP4 GPX1 MADD MST1R NICN1 RBM6 RNF123
Impedance of arm (right) 5.13 9 7 21.2 -0.68 2.3e-02 ERI1 GPX1 MAPT MST1R NICN1 RBM6 RNF123 TMEM106B UBXN2A
Arm fat percentage (right) 5.96 9 8 24.2 0.16 6.9e-01 ERI1 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123
Trunk fat-free mass 2.65 9 7 21.2 -0.04 9.3e-01 ARFGAP2 ARHGAP1 DDB2 ERI1 GPX1 MST1R RBM6 RNF123 UBXN2A
Hip circumference 3.52 9 6 18.2 0.30 4.4e-01 ERI1 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123
Alcohol intake versus 10 years previously 4.59 4 2 6.1 0.98 1.7e-02 FTSJ2 MST1R RBM6 RNF123
Father's age at death 3.84 2 0 0.0 0.00 1.0e+00 GPX1 NICN1
Worrier / anxious feelings 6.84 8 3 9.1 0.97 7.0e-05 B3GALTL ERI1 KCTD10 LINGO1 MAPT RP11-165J3.6 TCF4 TTC12
Frequency of tiredness / lethargy in last 2 weeks 8.62 9 3 9.1 0.98 4.4e-08 ARHGAP1 GPX1 KCTD10 NICN1 PAFAH1B1 RP11-165J3.6 TMEM106B TTC12 UBXN2A
Hair/balding pattern: Pattern 3 2.84 1 1 3.0 0.00 1.0e+00 MAPT
Number of live births 2.49 1 0 0.0 0.00 1.0e+00 MAPT
Forced expiratory volume in 1-second (FEV1) 4.27 6 4 12.1 -0.72 4.3e-02 ERI1 GPX1 MAPT NICN1 RNF123 UBXN2A
Pulse rate 2.09 1 0 0.0 0.00 1.0e+00 GPX1
Qualifications: A levels/AS levels or equivalent 8.04 6 5 15.2 -0.98 1.7e-05 GPX1 MAPT MST1R NICN1 RBM6 RNF123
Mouth/teeth dental problems: Dentures 3.63 4 1 3.0 1.00 4.3e-03 GPX1 MST1R RBM6 RNF123
Asthma 1.96 1 0 0.0 0.00 1.0e+00 MST1R
Medication: Ibuprofen (e.g. Nurofen) 2.30 2 0 0.0 0.00 1.0e+00 MAPT UBXN2A
Depression (self-reported) 3.26 1 0 0.0 0.00 1.0e+00 TMEM106B
Forced expiratory volume in 1-second (FEV1), Best measure 4.43 7 4 12.1 -0.54 1.4e-01 ERI1 FNBP4 GPX1 MAPT NICN1 RNF123 UBXN2A
Impedance of arm (left) 5.35 9 8 24.2 -0.69 1.9e-02 ERI1 GPX1 MAPT MST1R NICN1 RBM6 RNF123 TMEM106B UBXN2A
Arm fat mass (right) 6.03 9 8 24.2 0.27 4.8e-01 ERI1 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123
Trunk predicted mass 2.60 9 7 21.2 -0.04 9.2e-01 ARFGAP2 ARHGAP1 DDB2 ERI1 GPX1 MST1R RBM6 RNF123 UBXN2A
Standing height 1.52 13 6 18.2 -0.35 2.3e-01 ARFGAP2 DDB2 ERI1 FNBP4 FTSJ2 GPX1 MADD MAPT NICN1 PAFAH1B1 RP11-165J3.6 TMEM106B UBXN2A
Exposure to tobacco smoke at home 3.58 2 1 3.0 0.00 1.0e+00 GPX1 RNF123
Tense / 'highly strung' 5.44 3 3 9.1 0.00 1.0e+00 ERI1 RP11-165J3.6 TMEM106B
Seen doctor (GP) for nerves, anxiety, tension or depression 6.45 5 2 6.1 0.96 9.1e-03 B3GALTL FTSJ2 GPX1 TCF4 TMEM106B
Hair/balding pattern: Pattern 4 3.55 1 1 3.0 0.00 1.0e+00 MAPT
Birth weight of first child 1.67 1 0 0.0 0.00 1.0e+00 PAFAH1B1
Peak expiratory flow (PEF) 2.75 2 2 6.1 0.00 1.0e+00 ERI1 MAPT
Ever highly irritable/argumentative for 2 days 4.72 3 2 6.1 0.00 1.0e+00 MST1R RBM6 RNF123
Qualifications: O levels/GCSEs or equivalent 3.81 3 1 3.0 0.00 1.0e+00 GPX1 NICN1 RNF123
Medication: Paracetamol 5.29 6 2 6.1 0.96 4.4e-04 GPX1 KCTD10 MAPT NICN1 RNF123 UBXN2A
Headache pain in last month 2.76 2 1 3.0 0.00 1.0e+00 ERI1 MAPT
Medication for cholesterol, blood pressure or diabetes 2.17 1 0 0.0 0.00 1.0e+00 RNF123
Hypothyroidism/myxoedema (self-reported) 1.24 1 1 3.0 0.00 1.0e+00 ERI1
Medication: Ventolin 100micrograms inhaler 1.91 1 0 0.0 0.00 1.0e+00 MST1R
Birth weight 1.15 1 0 0.0 0.00 1.0e+00 UBXN2A
Chronic bronchitis/emphysema (mother) 3.35 1 0 0.0 0.00 1.0e+00 RNF123
High blood pressure (siblings) 2.31 2 0 0.0 0.00 1.0e+00 NR1H3 TMEM106B
Forced vital capacity (FVC), Best measure 4.01 8 2 6.1 -0.76 2.8e-02 ARFGAP2 DDB2 FNBP4 GPX1 MAPT NICN1 RNF123 UBXN2A
Body fat percentage 5.39 8 6 18.2 0.37 3.7e-01 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123
Leg fat percentage (right) 6.23 9 7 21.2 0.39 3.0e-01 ERI1 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123
Arm fat-free mass (right) 3.20 6 5 15.2 0.59 1.7e-01 ERI1 GPX1 MST1R RBM6 RNF123 UBXN2A
Exposure to tobacco smoke outside home 3.56 1 0 0.0 0.00 1.0e+00 RNF123
Comparative body size at age 10 3.43 4 4 12.1 -1.00 1.1e-03 ERI1 FNBP4 MADD RP11-165J3.6
Number of full brothers 3.49 1 0 0.0 0.00 1.0e+00 RNF123
Worry too long after embarrassment 4.25 3 1 3.0 0.00 1.0e+00 ERI1 MAPT TTC12
Seen a psychiatrist for nerves, anxiety, tension or depression 3.10 1 0 0.0 0.00 1.0e+00 TMEM106B
Wheeze or whistling in the chest in last year 5.38 5 3 9.1 0.95 1.5e-02 GPX1 MST1R RBM6 RNF123 RP11-165J3.6
Age at first live birth 6.55 5 4 12.1 -0.99 4.2e-05 GPX1 MST1R NICN1 RBM6 RNF123
Health satisfaction 3.83 2 0 0.0 0.00 1.0e+00 GPX1 RNF123
Qualifications: College or University degree 9.53 8 7 21.2 -0.98 1.4e-06 B3GALTL FTSJ2 GPX1 MAPT MST1R NICN1 RBM6 RNF123
Medication for pain relief, constipation, heartburn 3.61 3 1 3.0 0.00 1.0e+00 GPX1 MAPT RP11-165J3.6
Neck or shoulder pain in last month 3.53 1 0 0.0 0.00 1.0e+00 GPX1
Medication: Blood pressure 3.15 2 1 3.0 0.00 1.0e+00 ERI1 NR1H3
Medication: Seretide 50 evohaler 3.05 2 0 0.0 0.00 1.0e+00 RBM6 RNF123
Mean time to correctly identify matches 4.10 3 3 9.1 -1.00 3.2e-03 ARFGAP2 ARHGAP1 DDB2
Whole body fat mass 5.51 9 6 18.2 0.30 4.4e-01 ERI1 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123
Leg fat mass (right) 6.35 9 8 24.2 0.37 2.9e-01 ERI1 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123
Arm predicted mass (right) 3.35 8 6 18.2 0.44 2.4e-01 ARFGAP2 ERI1 GPX1 MST1R NICN1 RBM6 RNF123 UBXN2A
Pulse rate, automated reading 2.62 4 2 6.1 0.04 9.6e-01 GPX1 MST1R NR1H3 RBM6
Alcohol intake frequency. 5.16 7 6 18.2 0.44 3.3e-01 FNBP4 MADD MAPT MST1R RBM6 RNF123 TCF4
Comparative height size at age 10 1.89 6 4 12.1 -0.69 1.3e-01 ARFGAP2 DDB2 GPX1 MAPT TCF4 UBXN2A
Suffer from 'nerves' 6.83 7 2 6.1 0.98 1.0e-04 ARHGAP1 B3GALTL ERI1 FNBP4 MADD MAPT NR1H3
Overall health rating 8.32 8 5 15.2 0.99 1.3e-07 B3GALTL GPX1 MST1R NICN1 RBM6 RNF123 RP11-165J3.6 TTC12
Chest pain or discomfort 4.05 2 0 0.0 0.00 1.0e+00 GPX1 NICN1
Age at last live birth 6.59 5 4 12.1 -0.99 3.9e-05 GPX1 MST1R NICN1 RBM6 RNF123
Leg pain on walking 3.45 1 0 0.0 0.00 1.0e+00 RBM6
Qualifications: NVQ or HND or HNC or equivalent 2.68 2 0 0.0 0.00 1.0e+00 MST1R RBM6
Knee pain experienced in last month 2.56 1 0 0.0 0.00 1.0e+00 RBM6
Hypertension (Self-reported) 4.22 7 2 6.1 0.61 1.1e-01 ARFGAP2 ARHGAP1 DDB2 ERI1 FNBP4 MADD NR1H3
Whole body fat-free mass 2.80 9 5 15.2 0.09 8.1e-01 ARFGAP2 ARHGAP1 DDB2 ERI1 GPX1 MST1R RBM6 RNF123 UBXN2A
Leg fat-free mass (right) 2.80 7 5 15.2 0.02 9.7e-01 ARFGAP2 ERI1 FNBP4 MST1R RBM6 RNF123 UBXN2A
Arm fat percentage (left) 6.12 9 8 24.2 0.14 7.2e-01 ERI1 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123
Handedness (chirality/laterality): Left-handed 1.59 1 1 3.0 0.00 1.0e+00 MAPT
Mood swings 13.73 16 9 27.3 0.98 1.7e-13 ARHGAP1 ERI1 FNBP4 GPX1 MADD MAPT MST1R NICN1 NR1H3 PIGL RBM6 RNF123 RP11-165J3.6 TCF4 TMEM106B TTC12
Loneliness, isolation 7.82 6 2 6.1 0.99 3.9e-05 FNBP4 GPX1 MADD MAPT NICN1 TMEM106B
Diabetes diagnosed by doctor 2.79 3 0 0.0 0.00 1.0e+00 MST1R RBM6 RNF123
Qualifications: nursing, teaching 3.15 3 0 0.0 0.00 1.0e+00 B3GALTL RBM6 RNF123
Mouth/teeth dental problems: Mouth ulcers 1.81 1 1 3.0 0.00 1.0e+00 MAPT
Asthma (self-reported) 1.91 1 0 0.0 0.00 1.0e+00 MST1R
Osteoarthritis (self-reported) 2.80 1 0 0.0 0.00 1.0e+00 RBM6
Smoking status: Current 3.03 1 0 0.0 0.00 1.0e+00 UBXN2A
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.12 3 1 3.0 0.00 1.0e+00 GPX1 MAPT RNF123
Whole body water mass 2.86 9 5 15.2 0.10 7.9e-01 ARFGAP2 ARHGAP1 DDB2 ERI1 GPX1 MST1R RBM6 RNF123 UBXN2A
Leg predicted mass (right) 2.78 7 5 15.2 0.02 9.7e-01 ARFGAP2 ERI1 FNBP4 MST1R RBM6 RNF123 UBXN2A
Arm fat mass (left) 6.07 9 8 24.2 0.26 5.0e-01 ERI1 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123
Number of self-reported non-cancer illnesses 4.44 2 1 3.0 0.00 1.0e+00 FTSJ2 TMEM106B
Average weekly champagne plus white wine intake 2.09 1 0 0.0 0.00 1.0e+00 MAPT
Guilty feelings 9.03 9 2 6.1 0.96 3.0e-05 ERI1 FNBP4 LINGO1 MADD MAPT PAFAH1B1 RNF123 TTC12 UBXN2A
Financial situation satisfaction 4.63 2 1 3.0 0.00 1.0e+00 GPX1 RNF123
Medication: Blood pressure 2.59 3 1 3.0 0.00 1.0e+00 ERI1 MAPT NR1H3
Medication: Bendroflumethiazide 3.44 2 2 6.1 0.00 1.0e+00 ERI1 NR1H3
Medication: Paracetamol 5.54 5 3 9.1 0.98 1.3e-04 GPX1 MAPT NICN1 RNF123 UBXN2A
Illnesses of father: High blood pressure 2.34 2 0 0.0 0.00 1.0e+00 MADD NR1H3
Ever smoked 1.97 1 0 0.0 0.00 1.0e+00 GPX1
Basal metabolic rate 3.13 7 5 15.2 0.34 4.1e-01 ARFGAP2 ERI1 GPX1 MST1R RBM6 RNF123 UBXN2A
Leg fat percentage (left) 6.29 9 7 21.2 0.36 3.4e-01 ERI1 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123
Arm fat-free mass (left) 3.41 7 6 18.2 0.61 1.1e-01 ERI1 GPX1 MST1R NICN1 RBM6 RNF123 UBXN2A
Number of operations (self-reported) 3.85 3 0 0.0 0.99 1.2e-02 GPX1 RBM6 RNF123
Average weekly beer plus cider intake 4.62 4 2 6.1 1.00 5.0e-04 ERI1 MST1R RBM6 RNF123
Irritability 6.42 7 3 9.1 0.97 8.7e-05 ERI1 FTSJ2 GPX1 MAPT PAFAH1B1 TCF4 TMEM106B
Ever had prostate specific antigen (PSA) test 1.32 1 0 0.0 0.00 1.0e+00 PAFAH1B1
Age started oral contraceptive pill 3.43 1 0 0.0 0.00 1.0e+00 RNF123
Diastolic blood pressure, automated reading 4.00 9 4 12.1 0.67 4.8e-02 ERI1 FNBP4 GPX1 MADD MST1R NR1H3 PAFAH1B1 RBM6 RNF123
Ever depressed for a whole week 4.27 2 0 0.0 0.00 1.0e+00 GPX1 MAPT
Myopia 2.02 1 0 0.0 0.00 1.0e+00 FTSJ2
Vascular/heart problems diagnosed by doctor 4.11 6 2 6.1 -0.62 1.3e-01 ARFGAP2 ARHGAP1 DDB2 ERI1 MADD NR1H3
Pain experienced in last month 5.22 4 1 3.0 -1.00 2.7e-07 GPX1 NICN1 RBM6 RNF123
Pack years of smoking 2.61 1 0 0.0 0.00 1.0e+00 GPX1
Impedance of whole body 4.84 8 8 24.2 -0.62 5.6e-02 ERI1 GPX1 MAPT MST1R NICN1 RBM6 RNF123 UBXN2A
Leg fat mass (left) 6.49 9 8 24.2 0.41 2.4e-01 ERI1 FNBP4 FTSJ2 GPX1 MADD MST1R NICN1 RBM6 RNF123
Arm predicted mass (left) 3.39 7 6 18.2 0.60 1.1e-01 ERI1 GPX1 MST1R NICN1 RBM6 RNF123 UBXN2A

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 16 0.4583 1.71
GTEx Adipose Visceral Omentum 14 0.6876 1.88
GTEx Adrenal Gland 8 0.5491 1.80
GTEx Artery Aorta 18 0.6046 1.82
GTEx Artery Coronary 13 1.0989 1.98
GTEx Artery Tibial 16 0.4254 1.76
GTEx Brain Caudate basal ganglia 8 0.8696 1.96
GTEx Brain Cerebellar Hemisphere 11 0.7388 1.84
GTEx Brain Cerebellum 12 0.6054 1.81
GTEx Brain Cortex 13 1.2560 1.98
GTEx Brain Frontal Cortex BA9 10 1.0823 1.94
GTEx Brain Hippocampus 5 0.9542 1.85
GTEx Brain Hypothalamus 4 0.6780 1.96
GTEx Brain Nucleus accumbens basal ganglia 7 0.8092 1.79
GTEx Brain Putamen basal ganglia 5 0.8013 1.90
GTEx Breast Mammary Tissue 13 0.6586 1.81
GTEx Breast Mammary Tissue (Male) 6 0.5029 1.64
GTEx Breast Mammary Tissue (Female) 12 0.7299 1.81
GTEx Cells EBV-transformed lymphocytes 12 0.8433 1.85
GTEx Cells Transformed fibroblasts 20 0.4763 1.75
GTEx Colon Sigmoid 15 1.0260 1.98
GTEx Colon Transverse 14 0.6783 1.82
GTEx Esophagus Gastroesophageal Junction 13 0.8997 1.96
GTEx Esophagus Mucosa 16 0.4819 1.78
GTEx Esophagus Muscularis 21 0.6498 1.84
GTEx Heart Atrial Appendage 14 0.8866 1.91
GTEx Heart Left Ventricle 13 0.8497 1.93
GTEx Liver 5 0.6974 1.77
GTEx Lung 22 0.7658 1.86
GTEx Muscle Skeletal 11 0.3806 1.72
GTEx Nerve Tibial 18 0.4166 1.72
GTEx Ovary 8 0.8811 1.98
GTEx Pancreas 11 0.6740 1.88
GTEx Pituitary 8 0.7175 1.81
GTEx Prostate 9 1.0778 1.97
GTEx Skin Not Sun Exposed Suprapubic 18 0.7320 1.94
GTEx Skin Sun Exposed Lower leg 20 0.5495 1.81
GTEx Small Intestine Terminal Ileum 7 1.5184 2.11
GTEx Spleen 13 0.9213 1.89
GTEx Stomach 11 0.7565 1.86
GTEx Testis 19 0.6022 1.84
GTEx Thyroid 21 0.5251 1.76
GTEx Uterus 9 1.5873 2.17
GTEx Vagina 7 1.1024 1.95
GTEx Whole Blood 9 0.4516 1.69
METSIM Adipose 8 0.1735 1.60
NTR Blood 9 0.3747 1.73
ROSMAP Brain Pre-frontal Cortex 20 0.4555 1.83
YFS Blood 6 0.1299 1.61
CommonMind Brain Pre-frontal Cortex 10 0.1860 1.68
TCGA Breast Tumor 2 0.2608 1.70
TCGA Breast Normal 4 0.0951 1.53
TCGA Ovarian Tumor 8 0.2738 1.62
TCGA Prostate Tumor 6 0.1735 1.59