Hub : Traits :

Number of treatments/medications taken

178 significantly associated models · 37 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 109126153 110517617 1 1 2.4e-07 1.5e-07 1.0e+00 100 PSRC1
2 1 173437024 175663031 1 1 4.1e-07 5.0e-08 4.0e-02 86 RABGAP1L
3 2 26624843 28038799 1 1 2.5e-07 3.7e-06 8.5e-05 28 CGREF1
4 3 48702606 50932324 13 1 8.5e-12 2.6e-11 2.6e-01 97 MST1R
5 4 102852939 104712494 7 1 1.5e-10 9.8e-10 1.0e+00 100 CISD2
6 5 113846922 115239004 1 1 2.8e-07 5.4e-06 2.8e-03 57 CTC-428G20.3
7 7 73425238 74494207 2 1 2.7e-08 1.2e-06 1.2e-01 90 PMS2P5
8 10 21123825 22724472 1 1 5.8e-08 1.6e-07 2.7e-01 96 MLLT10
9 10 133048749 134466163 1 1 1.4e-07 8.5e-07 8.4e-02 88 PPP2R2D
10 11 100168289 101559718 1 1 1.7e-07 1.1e-06 2.4e-02 78 TMEM133
11 12 111154626 113517494 3 1 1.1e-09 1.7e-14 1.2e-06 60 SH2B3
12 14 74424938 76089054 3 1 3.7e-11 6.1e-11 3.3e-01 98 RPS6KL1
13 15 80377452 81936479 1 1 3.9e-08 1.6e-09 1.1e-02 82 KIAA1199
14 17 65431947 66828158 1 1 2.2e-07 5.1e-07 6.1e-01 99 SH3GL1P3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 3.03 1 1 3.0 0.00 1.0e+00 MST1R
Irritable Bowel Disease (IBD) 4.07 2 1 3.0 0.00 1.0e+00 MST1R PMS2P5
Ulcerative Colitis (UC) 3.91 2 1 3.0 0.00 1.0e+00 CISD2 MST1R
Major Depression (MDD) 2.15 1 0 0.0 0.00 1.0e+00 RPS6KL1
Reaction Time 2.87 1 1 3.0 0.00 1.0e+00 SH2B3
Verbal and Numeric Reasoning (VNR) 3.03 1 1 3.0 0.00 1.0e+00 MST1R
Breast Cancer 2.49 1 1 3.0 0.00 1.0e+00 MLLT10
Ovarian Cancer 2.84 1 1 3.0 0.00 1.0e+00 MLLT10
Age at First Birth 4.71 1 1 3.0 0.00 1.0e+00 MST1R
Coronary Artery Disease (CAD) 5.51 3 1 3.0 0.00 1.0e+00 MST1R PSRC1 SH2B3
Crohns Disease (2012) 3.20 1 1 3.0 0.00 1.0e+00 MST1R
Fasting Glucose 4.28 1 1 3.0 0.00 1.0e+00 CGREF1
HDL Cholesterol 2.63 2 0 0.0 0.00 1.0e+00 MST1R PSRC1
LDL Cholesterol 40.42 2 1 3.0 0.00 1.0e+00 PSRC1 SH2B3
Neuroticism 2.59 1 0 0.0 0.00 1.0e+00 RPS6KL1
Primary Biliary Cirrhosis 3.00 2 1 3.0 0.00 1.0e+00 CISD2 SH2B3
Rheumatoid Arthritis 2.57 1 0 0.0 0.00 1.0e+00 SH2B3
Schizophrenia 1.18 1 0 0.0 0.00 1.0e+00 CISD2
Triglycerides 6.91 2 1 3.0 0.00 1.0e+00 CGREF1 SH3GL1P3
Type 2 Diabetes (T2D) 2.22 1 0 0.0 0.00 1.0e+00 CISD2
Ulcerative Colitis 2.94 1 1 3.0 0.00 1.0e+00 MST1R
Blood Eosinophil Count 14.48 3 3 9.1 0.00 1.0e+00 MST1R SH2B3 SH3GL1P3
Blood Platelet Count 3.74 3 3 9.1 0.00 1.0e+00 CGREF1 RPS6KL1 SH2B3
Blood Red Count 2.45 4 2 6.1 -0.99 5.0e-03 PMS2P5 RABGAP1L SH2B3 TMEM133
Blood White Count 7.74 5 3 9.1 -0.81 9.7e-02 CGREF1 KIAA1199 MST1R RABGAP1L SH2B3
Heel T-Score 1.66 7 1 3.0 -0.29 5.3e-01 MST1R PMS2P5 PSRC1 RABGAP1L RPS6KL1 SH3GL1P3 TMEM133
BMI 6.11 7 5 15.2 -0.93 2.3e-03 CISD2 CTC-428G20.3 KIAA1199 MLLT10 MST1R PMS2P5 SH3GL1P3
Height 1.18 7 6 18.2 0.69 8.8e-02 CGREF1 PPP2R2D PSRC1 RPS6KL1 SH2B3 SH3GL1P3 TMEM133
Systolic Blood Pressure 10.44 9 5 15.2 -0.73 2.6e-02 CGREF1 KIAA1199 MLLT10 PMS2P5 PPP2R2D RPS6KL1 SH2B3 SH3GL1P3 TMEM133
Smoking Status 3.21 3 1 3.0 0.00 1.0e+00 KIAA1199 MLLT10 RABGAP1L
Allergy or Eczema 1.40 2 0 0.0 0.00 1.0e+00 CISD2 SH2B3
Cardiovascular Disease 11.87 8 7 21.2 -0.94 4.3e-04 CGREF1 CISD2 KIAA1199 MLLT10 PMS2P5 PSRC1 SH2B3 TMEM133
Hypothyroidism (self reported) 9.01 2 1 3.0 0.00 1.0e+00 RPS6KL1 SH2B3
Respiratory disease 2.54 2 0 0.0 0.00 1.0e+00 MST1R RABGAP1L
Type 2 Diabetes (T2D) 2.94 2 0 0.0 0.00 1.0e+00 MST1R SH2B3
Lung FEV1/FVC ratio 3.01 5 4 12.1 -0.16 8.0e-01 MLLT10 PSRC1 RPS6KL1 SH3GL1P3 TMEM133
Lung FVC 2.01 5 1 3.0 0.71 1.8e-01 MLLT10 MST1R SH2B3 SH3GL1P3 TMEM133
Neuroticism 4.62 3 1 3.0 0.00 1.0e+00 MST1R RABGAP1L RPS6KL1
Hair Pigment 0.27 3 1 3.0 0.00 1.0e+00 CGREF1 SH2B3 SH3GL1P3
Tanning 0.39 2 0 0.0 0.00 1.0e+00 RPS6KL1 SH2B3
Hand grip strength (left) 2.07 3 0 0.0 0.00 1.0e+00 MLLT10 RPS6KL1 SH3GL1P3
Relative age of first facial hair 2.14 2 0 0.0 0.00 1.0e+00 PMS2P5 RABGAP1L
Other serious medical condition/disability diagnosed by doctor 3.29 1 0 0.0 0.00 1.0e+00 PMS2P5
Ever used hormone-replacement therapy (HRT) 2.30 1 0 0.0 0.00 1.0e+00 SH3GL1P3
Ever had hysterectomy (womb removed) 3.24 1 0 0.0 0.00 1.0e+00 MLLT10
Systolic blood pressure, automated reading 8.48 5 3 9.1 0.92 2.9e-02 KIAA1199 PMS2P5 RPS6KL1 SH2B3 TMEM133
Angina 5.27 1 1 3.0 0.00 1.0e+00 PSRC1
Medication: Co-codamol 3.01 1 0 0.0 0.00 1.0e+00 MST1R
Medication: Metformin 2.88 1 0 0.0 0.00 1.0e+00 CISD2
Impedance of leg (right) 2.53 4 3 9.1 -0.68 3.2e-01 KIAA1199 MST1R PMS2P5 RPS6KL1
Leg fat-free mass (left) 3.46 8 2 6.1 0.46 2.5e-01 CGREF1 KIAA1199 MLLT10 MST1R PMS2P5 PPP2R2D SH2B3 SH3GL1P3
Trunk fat percentage 5.34 5 3 9.1 0.94 1.7e-02 MLLT10 MST1R PMS2P5 RPS6KL1 SH3GL1P3
Hand grip strength (right) 1.87 2 0 0.0 0.00 1.0e+00 MLLT10 SH3GL1P3
Current tobacco smoking 2.35 1 0 0.0 0.00 1.0e+00 SH3GL1P3
Maternal smoking around birth 3.20 2 0 0.0 0.00 1.0e+00 MLLT10 MST1R
Fed-up feelings 5.73 3 3 9.1 0.00 1.0e+00 MST1R RPS6KL1 SH2B3
Relative age voice broke 2.04 1 0 0.0 0.00 1.0e+00 PMS2P5
Taking other prescription medications 11.52 9 3 9.1 0.99 4.5e-08 CISD2 KIAA1199 MLLT10 MST1R PMS2P5 RABGAP1L RPS6KL1 SH2B3 SH3GL1P3
Age when periods started (menarche) 2.32 2 1 3.0 0.00 1.0e+00 MST1R PMS2P5
Bilateral oophorectomy (both ovaries removed) 3.21 1 0 0.0 0.00 1.0e+00 MLLT10
Heel bone mineral density (BMD) T-score, automated (left) 1.69 1 0 0.0 0.00 1.0e+00 MST1R
Qualifications: CSEs or equivalent 2.29 1 0 0.0 0.00 1.0e+00 MST1R
High blood pressure 9.84 8 4 12.1 0.95 2.7e-04 CGREF1 CISD2 CTC-428G20.3 KIAA1199 MLLT10 PMS2P5 SH2B3 TMEM133
Medication: Atenolol 6.39 3 1 3.0 0.00 1.0e+00 PSRC1 SH2B3 TMEM133
Medication: Levothyroxine sodium 7.41 1 1 3.0 0.00 1.0e+00 SH2B3
Sitting height 1.08 4 0 0.0 0.72 2.8e-01 CGREF1 KIAA1199 MLLT10 PPP2R2D
High blood pressure (mother) 2.73 1 0 0.0 0.00 1.0e+00 CGREF1
Body mass index (BMI) 6.43 5 4 12.1 0.97 5.6e-03 KIAA1199 MLLT10 MST1R PMS2P5 SH3GL1P3
Impedance of leg (left) 2.54 4 3 9.1 -0.64 3.6e-01 KIAA1199 MST1R PMS2P5 RPS6KL1
Leg predicted mass (left) 3.46 8 2 6.1 0.46 2.5e-01 CGREF1 KIAA1199 MLLT10 MST1R PMS2P5 PPP2R2D SH2B3 SH3GL1P3
Trunk fat mass 5.51 5 3 9.1 0.99 2.2e-03 KIAA1199 MLLT10 MST1R PMS2P5 SH3GL1P3
Waist circumference 6.06 5 5 15.2 0.98 3.0e-03 KIAA1199 MLLT10 MST1R PMS2P5 SH3GL1P3
Past tobacco smoking 3.30 3 0 0.0 0.00 1.0e+00 MLLT10 RPS6KL1 SH2B3
Alcohol usually taken with meals 3.31 1 1 3.0 0.00 1.0e+00 RABGAP1L
Nervous feelings 2.08 1 1 3.0 0.00 1.0e+00 RPS6KL1
Frequency of tenseness / restlessness in last 2 weeks 3.26 1 0 0.0 0.00 1.0e+00 MST1R
Forced vital capacity (FVC) 1.97 4 0 0.0 -1.00 1.2e-03 MLLT10 MST1R PPP2R2D TMEM133
Heel bone mineral density (BMD) T-score, automated (right) 1.60 1 0 0.0 0.00 1.0e+00 MST1R
Ever unenthusiastic/disinterested for a whole week 2.80 1 0 0.0 0.00 1.0e+00 RPS6KL1
Qualifications: None of the above 4.41 2 2 6.1 0.00 1.0e+00 MST1R PPP2R2D
Heart attack 4.22 2 1 3.0 0.00 1.0e+00 PSRC1 SH2B3
Diabetes (self-reported) 3.29 2 0 0.0 0.00 1.0e+00 MST1R PMS2P5
Medication: Ramipril 5.08 2 0 0.0 0.00 1.0e+00 CISD2 TMEM133
Medication: Simvastatin 10.94 1 1 3.0 0.00 1.0e+00 PSRC1
Fluid intelligence score 3.19 1 1 3.0 0.00 1.0e+00 MST1R
Illnesses of siblings 5.30 2 0 0.0 0.00 1.0e+00 SH2B3 TMEM133
Neuroticism score 4.16 3 1 3.0 0.00 1.0e+00 MST1R RABGAP1L RPS6KL1
Weight 5.22 6 5 15.2 0.77 7.5e-02 KIAA1199 MLLT10 MST1R PMS2P5 SH2B3 SH3GL1P3
Impedance of arm (right) 3.93 7 2 6.1 -0.60 1.5e-01 CGREF1 CISD2 KIAA1199 MLLT10 MST1R PMS2P5 SH2B3
Arm fat percentage (right) 5.29 5 4 12.1 0.95 1.4e-02 MLLT10 MST1R PMS2P5 RPS6KL1 SH3GL1P3
Trunk fat-free mass 3.40 6 5 15.2 -0.21 6.9e-01 CGREF1 KIAA1199 MST1R PSRC1 RPS6KL1 SH2B3
Hip circumference 4.31 6 4 12.1 0.74 9.4e-02 KIAA1199 MLLT10 MST1R PMS2P5 SH2B3 SH3GL1P3
Alcohol intake versus 10 years previously 3.56 1 1 3.0 0.00 1.0e+00 MST1R
Father's age at death 4.48 3 1 3.0 0.00 1.0e+00 MST1R PSRC1 SH2B3
Worrier / anxious feelings 2.57 1 1 3.0 0.00 1.0e+00 RPS6KL1
Frequency of tiredness / lethargy in last 2 weeks 3.34 1 0 0.0 0.00 1.0e+00 RABGAP1L
Number of live births 2.33 2 0 0.0 0.00 1.0e+00 CISD2 MST1R
Forced expiratory volume in 1-second (FEV1) 2.09 4 1 3.0 -0.99 6.6e-03 MST1R PPP2R2D RABGAP1L TMEM133
Qualifications: A levels/AS levels or equivalent 5.95 3 1 3.0 0.00 1.0e+00 MLLT10 MST1R PPP2R2D
Mouth/teeth dental problems: Dentures 2.50 1 1 3.0 0.00 1.0e+00 MST1R
Asthma 2.50 3 0 0.0 0.00 1.0e+00 MLLT10 MST1R RABGAP1L
Medication: Cholesterol lowering 15.31 3 1 3.0 0.00 1.0e+00 CGREF1 PSRC1 TMEM133
Prospective memory result 2.83 1 0 0.0 0.00 1.0e+00 MST1R
Forced expiratory volume in 1-second (FEV1), Best measure 1.86 3 0 0.0 0.00 1.0e+00 MST1R PPP2R2D TMEM133
Impedance of arm (left) 4.15 7 3 9.1 -0.57 1.8e-01 CGREF1 CISD2 KIAA1199 MLLT10 MST1R PMS2P5 SH2B3
Arm fat mass (right) 5.85 5 4 12.1 0.99 1.3e-03 KIAA1199 MLLT10 MST1R PMS2P5 SH3GL1P3
Trunk predicted mass 3.37 6 5 15.2 -0.21 6.9e-01 CGREF1 KIAA1199 MST1R PSRC1 RPS6KL1 SH2B3
Standing height 1.42 6 4 12.1 -0.73 9.9e-02 CGREF1 PPP2R2D PSRC1 RPS6KL1 SH2B3 SH3GL1P3
Exposure to tobacco smoke at home 2.06 1 0 0.0 0.00 1.0e+00 MST1R
Tense / 'highly strung' 2.53 2 0 0.0 0.00 1.0e+00 RABGAP1L RPS6KL1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.65 1 0 0.0 0.00 1.0e+00 RPS6KL1
Birth weight of first child 2.99 1 1 3.0 0.00 1.0e+00 SH2B3
Peak expiratory flow (PEF) 1.50 1 0 0.0 0.00 1.0e+00 MLLT10
Ever highly irritable/argumentative for 2 days 3.32 1 1 3.0 0.00 1.0e+00 MST1R
Qualifications: O levels/GCSEs or equivalent 3.07 2 0 0.0 0.00 1.0e+00 MST1R PPP2R2D
Blood clot in the leg (DVT) 1.97 1 0 0.0 0.00 1.0e+00 SH2B3
Medication: Paracetamol 4.98 3 0 0.0 0.00 1.0e+00 CGREF1 MLLT10 RABGAP1L
Medication for cholesterol, blood pressure or diabetes 11.23 7 3 9.1 -0.95 8.2e-04 CGREF1 CISD2 KIAA1199 MST1R PSRC1 SH2B3 TMEM133
Gout (self-reported) 3.78 2 1 3.0 0.00 1.0e+00 CGREF1 SH2B3
Hypothyroidism/myxoedema (self-reported) 7.43 1 1 3.0 0.00 1.0e+00 SH2B3
Medication: Amlodipine 5.55 2 2 6.1 0.00 1.0e+00 KIAA1199 TMEM133
Medication: Ventolin 100micrograms inhaler 2.80 1 0 0.0 0.00 1.0e+00 MST1R
Birth weight 2.27 1 1 3.0 0.00 1.0e+00 SH2B3
Chronic bronchitis/emphysema (mother) 3.05 1 0 0.0 0.00 1.0e+00 MST1R
High blood pressure (siblings) 6.19 5 0 0.0 0.99 6.3e-04 CGREF1 KIAA1199 PPP2R2D SH2B3 TMEM133
Forced vital capacity (FVC), Best measure 1.79 2 1 3.0 0.00 1.0e+00 MLLT10 MST1R
Body fat percentage 6.06 5 4 12.1 0.95 1.3e-02 MLLT10 MST1R PMS2P5 RPS6KL1 SH3GL1P3
Leg fat percentage (right) 7.10 5 4 12.1 0.95 1.3e-02 MLLT10 MST1R PMS2P5 RPS6KL1 SH3GL1P3
Arm fat-free mass (right) 4.10 7 3 9.1 0.27 5.6e-01 CGREF1 KIAA1199 MLLT10 MST1R PSRC1 SH2B3 SH3GL1P3
Exposure to tobacco smoke outside home 2.63 2 0 0.0 0.00 1.0e+00 MST1R SH2B3
Wheeze or whistling in the chest in last year 5.43 4 1 3.0 0.96 3.6e-02 MST1R RABGAP1L RPS6KL1 SH3GL1P3
Age at first live birth 4.57 1 1 3.0 0.00 1.0e+00 MST1R
Health satisfaction 4.13 2 0 0.0 0.00 1.0e+00 MST1R SH3GL1P3
Qualifications: College or University degree 6.27 4 3 9.1 -1.00 3.8e-03 MLLT10 MST1R PPP2R2D RABGAP1L
Emphysema/chronic bronchitis 2.88 1 0 0.0 0.00 1.0e+00 RABGAP1L
Medication for pain relief, constipation, heartburn 7.61 7 1 3.0 -0.99 7.1e-06 CGREF1 CISD2 KIAA1199 MLLT10 RABGAP1L RPS6KL1 SH3GL1P3
Medication: Blood pressure 9.00 4 4 12.1 0.99 7.0e-03 CISD2 KIAA1199 SH2B3 TMEM133
Angina (self-reported) 5.26 1 1 3.0 0.00 1.0e+00 PSRC1
Medication: Allopurinol 2.93 2 0 0.0 0.00 1.0e+00 CGREF1 SH2B3
Medication: Omeprazole 3.42 1 0 0.0 0.00 1.0e+00 MST1R
Medication: Seretide 50 evohaler 2.16 1 0 0.0 0.00 1.0e+00 MST1R
Mean time to correctly identify matches 3.59 1 1 3.0 0.00 1.0e+00 SH2B3
Whole body fat mass 6.16 5 4 12.1 0.99 1.9e-03 KIAA1199 MLLT10 MST1R PMS2P5 SH3GL1P3
Leg fat mass (right) 7.00 5 4 12.1 0.98 4.0e-03 KIAA1199 MLLT10 MST1R PMS2P5 SH3GL1P3
Arm predicted mass (right) 4.22 7 4 12.1 0.29 5.3e-01 CGREF1 KIAA1199 MLLT10 MST1R PSRC1 SH2B3 SH3GL1P3
Pulse rate, automated reading 2.50 4 0 0.0 1.00 4.6e-03 CGREF1 MST1R PMS2P5 RABGAP1L
Alcohol intake frequency. 4.82 3 3 9.1 0.00 1.0e+00 CGREF1 MST1R PMS2P5
Comparative height size at age 10 2.59 7 2 6.1 -0.21 6.6e-01 CGREF1 KIAA1199 PMS2P5 PSRC1 RPS6KL1 SH2B3 SH3GL1P3
Suffer from 'nerves' 1.93 1 0 0.0 0.00 1.0e+00 RPS6KL1
Overall health rating 7.74 8 2 6.1 0.98 3.3e-05 CISD2 CTC-428G20.3 MLLT10 MST1R PMS2P5 PPP2R2D RABGAP1L SH3GL1P3
Age at last live birth 5.28 2 1 3.0 0.00 1.0e+00 MST1R SH3GL1P3
Leg pain on walking 3.30 1 1 3.0 0.00 1.0e+00 MST1R
Qualifications: NVQ or HND or HNC or equivalent 2.74 1 0 0.0 0.00 1.0e+00 MST1R
Medication: Aspirin 5.85 2 1 3.0 0.00 1.0e+00 PSRC1 SH2B3
Knee pain experienced in last month 4.06 3 0 0.0 0.00 1.0e+00 CTC-428G20.3 MST1R RABGAP1L
Hypertension (Self-reported) 9.58 8 4 12.1 0.95 2.5e-04 CGREF1 CISD2 CTC-428G20.3 KIAA1199 MLLT10 PMS2P5 SH2B3 TMEM133
Illnesses of father: Heart disease 4.28 2 1 3.0 0.00 1.0e+00 PSRC1 SH2B3
Smoking status: Previous 3.65 3 0 0.0 0.00 1.0e+00 MLLT10 RPS6KL1 SH2B3
Whole body fat-free mass 3.54 8 3 9.1 0.08 8.4e-01 CGREF1 KIAA1199 MLLT10 MST1R PSRC1 RPS6KL1 SH2B3 SH3GL1P3
Leg fat-free mass (right) 3.30 10 2 6.1 0.17 6.3e-01 CGREF1 KIAA1199 MLLT10 MST1R PMS2P5 PPP2R2D PSRC1 RPS6KL1 SH2B3 SH3GL1P3
Arm fat percentage (left) 5.47 5 4 12.1 0.95 1.5e-02 MLLT10 MST1R PMS2P5 RPS6KL1 SH3GL1P3
Mood swings 3.84 2 2 6.1 0.00 1.0e+00 MST1R RPS6KL1
Loneliness, isolation 4.38 3 0 0.0 0.00 1.0e+00 MST1R SH2B3 SH3GL1P3
Long-standing illness, disability or infirmity 5.59 3 0 0.0 0.00 1.0e+00 CTC-428G20.3 PMS2P5 SH3GL1P3
Ever had bowel cancer screening 2.31 2 0 0.0 0.00 1.0e+00 MLLT10 MST1R
Diabetes diagnosed by doctor 3.19 1 0 0.0 0.00 1.0e+00 MST1R
Qualifications: nursing, teaching 3.03 1 0 0.0 0.00 1.0e+00 MST1R
Mouth/teeth dental problems: Mouth ulcers 1.52 1 0 0.0 0.00 1.0e+00 SH2B3
Medication for cholesterol 9.37 7 3 9.1 -0.99 2.1e-05 CGREF1 CISD2 KIAA1199 PSRC1 RPS6KL1 SH2B3 TMEM133
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.39 1 0 0.0 0.00 1.0e+00 CGREF1
Breast cancer (self-reported) 1.74 1 0 0.0 0.00 1.0e+00 MLLT10
Asthma (self-reported) 2.39 2 0 0.0 0.00 1.0e+00 MST1R RABGAP1L
Osteoarthritis (self-reported) 2.81 1 0 0.0 0.00 1.0e+00 MST1R
Medication: Aspirin 5.96 1 1 3.0 0.00 1.0e+00 PSRC1
Illnesses of father: None of the above (group 1) 2.70 1 0 0.0 0.00 1.0e+00 SH2B3
Smoking status: Current 2.47 1 0 0.0 0.00 1.0e+00 SH3GL1P3
Whole body water mass 3.58 8 3 9.1 0.09 8.3e-01 CGREF1 KIAA1199 MLLT10 MST1R PSRC1 RPS6KL1 SH2B3 SH3GL1P3
Leg predicted mass (right) 3.30 10 2 6.1 0.17 6.4e-01 CGREF1 KIAA1199 MLLT10 MST1R PMS2P5 PPP2R2D PSRC1 RPS6KL1 SH2B3 SH3GL1P3
Arm fat mass (left) 5.90 5 4 12.1 0.99 1.6e-03 KIAA1199 MLLT10 MST1R PMS2P5 SH3GL1P3
Number of self-reported non-cancer illnesses 9.54 9 3 9.1 0.98 6.1e-06 CGREF1 CISD2 KIAA1199 MLLT10 MST1R PMS2P5 RPS6KL1 SH2B3 TMEM133
Average weekly champagne plus white wine intake 2.40 1 0 0.0 0.00 1.0e+00 RABGAP1L
Miserableness 3.86 2 1 3.0 0.00 1.0e+00 MST1R RABGAP1L
Guilty feelings 3.06 1 1 3.0 0.00 1.0e+00 RPS6KL1
Mother's age at death 2.69 1 0 0.0 0.00 1.0e+00 PMS2P5
Financial situation satisfaction 2.29 1 0 0.0 0.00 1.0e+00 MST1R
Medication: Blood pressure 7.90 5 3 9.1 0.98 3.8e-03 CISD2 KIAA1199 RPS6KL1 SH2B3 TMEM133
High cholesterol (Self-reported) 17.85 3 2 6.1 0.00 1.0e+00 CGREF1 PSRC1 TMEM133
Medication: Bendroflumethiazide 5.12 3 0 0.0 0.00 1.0e+00 CISD2 KIAA1199 SH2B3
Medication: Paracetamol 5.33 3 0 0.0 0.00 1.0e+00 CGREF1 MLLT10 RABGAP1L
Medication: Lisinopril 2.64 1 0 0.0 0.00 1.0e+00 SH2B3
Medication: Atorvastatin 10.06 2 1 3.0 0.00 1.0e+00 CGREF1 PSRC1
Illnesses of father: High blood pressure 3.64 1 0 0.0 0.00 1.0e+00 SH2B3
Ever smoked 1.89 1 0 0.0 0.00 1.0e+00 SH2B3
Basal metabolic rate 3.89 7 4 12.1 0.34 4.5e-01 CGREF1 KIAA1199 MLLT10 MST1R PSRC1 SH2B3 SH3GL1P3
Leg fat percentage (left) 7.04 5 4 12.1 0.96 1.1e-02 MLLT10 MST1R PMS2P5 RPS6KL1 SH3GL1P3
Arm fat-free mass (left) 4.34 7 3 9.1 0.29 5.2e-01 CGREF1 KIAA1199 MLLT10 MST1R PSRC1 SH2B3 SH3GL1P3
Number of operations (self-reported) 3.89 2 0 0.0 0.00 1.0e+00 MLLT10 MST1R
Average weekly beer plus cider intake 2.47 1 1 3.0 0.00 1.0e+00 MST1R
Irritability 1.60 1 0 0.0 0.00 1.0e+00 RPS6KL1
Fractured/broken bones in last 5 years 1.65 1 0 0.0 0.00 1.0e+00 SH3GL1P3
Age started oral contraceptive pill 1.40 1 0 0.0 0.00 1.0e+00 MST1R
Diastolic blood pressure, automated reading 10.38 8 5 15.2 0.90 2.3e-03 CISD2 CTC-428G20.3 KIAA1199 MLLT10 MST1R PMS2P5 SH2B3 TMEM133
Myopia 1.32 1 0 0.0 0.00 1.0e+00 SH3GL1P3
Vascular/heart problems diagnosed by doctor 10.60 9 6 18.2 -0.95 1.1e-04 CGREF1 CISD2 CTC-428G20.3 KIAA1199 MLLT10 PMS2P5 PPP2R2D SH2B3 TMEM133
Cholesterol lowering medication 9.24 1 1 3.0 0.00 1.0e+00 PSRC1
Pain experienced in last month 5.91 6 1 3.0 -0.69 1.3e-01 KIAA1199 MLLT10 MST1R RABGAP1L SH2B3 SH3GL1P3
Heart attack/myocardial infarction (self-reported) 4.24 2 1 3.0 0.00 1.0e+00 PSRC1 SH2B3
Impedance of whole body 3.53 6 4 12.1 -0.83 4.2e-02 CGREF1 CISD2 KIAA1199 MLLT10 MST1R PMS2P5
Leg fat mass (left) 7.02 5 4 12.1 0.98 3.3e-03 KIAA1199 MLLT10 MST1R PMS2P5 SH3GL1P3
Arm predicted mass (left) 4.37 7 3 9.1 0.29 5.2e-01 CGREF1 KIAA1199 MLLT10 MST1R PSRC1 SH2B3 SH3GL1P3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 3 0.0859 1.89
GTEx Adipose Visceral Omentum 2 0.0982 1.88
GTEx Adrenal Gland 3 0.2059 1.78
GTEx Artery Aorta 6 0.2015 1.97
GTEx Artery Coronary 2 0.1691 1.80
GTEx Artery Tibial 7 0.1861 1.90
GTEx Brain Caudate basal ganglia 2 0.2174 1.83
GTEx Brain Cerebellar Hemisphere 3 0.2015 1.87
GTEx Brain Cerebellum 5 0.2523 2.09
GTEx Brain Cortex 3 0.2899 1.93
GTEx Brain Frontal Cortex BA9 2 0.2165 1.86
GTEx Brain Hippocampus 0 0.0000 1.89
GTEx Brain Hypothalamus 0 0.0000 1.60
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.73
GTEx Brain Putamen basal ganglia 1 0.1603 1.74
GTEx Breast Mammary Tissue 3 0.1520 1.90
GTEx Breast Mammary Tissue (Male) 1 0.0838 1.75
GTEx Breast Mammary Tissue (Female) 2 0.1217 1.80
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.77
GTEx Cells Transformed fibroblasts 8 0.1905 1.91
GTEx Colon Sigmoid 3 0.2052 1.93
GTEx Colon Transverse 3 0.1453 1.84
GTEx Esophagus Gastroesophageal Junction 3 0.2076 1.89
GTEx Esophagus Mucosa 6 0.1807 1.91
GTEx Esophagus Muscularis 4 0.1238 1.82
GTEx Heart Atrial Appendage 2 0.1267 1.89
GTEx Heart Left Ventricle 1 0.0654 1.81
GTEx Liver 1 0.1395 1.82
GTEx Lung 5 0.1740 1.86
GTEx Muscle Skeletal 4 0.1384 1.88
GTEx Nerve Tibial 6 0.1389 1.85
GTEx Ovary 1 0.1101 1.85
GTEx Pancreas 2 0.1225 1.86
GTEx Pituitary 2 0.1794 1.82
GTEx Prostate 1 0.1198 1.91
GTEx Skin Not Sun Exposed Suprapubic 7 0.2847 1.98
GTEx Skin Sun Exposed Lower leg 8 0.2198 1.92
GTEx Small Intestine Terminal Ileum 2 0.4338 2.03
GTEx Spleen 3 0.2126 1.84
GTEx Stomach 2 0.1376 1.81
GTEx Testis 3 0.0951 1.86
GTEx Thyroid 5 0.1250 1.83
GTEx Uterus 1 0.1764 1.74
GTEx Vagina 1 0.1575 1.80
GTEx Whole Blood 3 0.1505 1.88
METSIM Adipose 5 0.1085 1.76
NTR Blood 3 0.1249 1.78
ROSMAP Brain Pre-frontal Cortex 10 0.2277 1.82
YFS Blood 3 0.0650 1.66
CommonMind Brain Pre-frontal Cortex 8 0.1488 1.78
TCGA Breast Tumor 1 0.1304 1.68
TCGA Breast Normal 7 0.1664 1.66
TCGA Ovarian Tumor 2 0.0684 1.69
TCGA Prostate Tumor 5 0.1446 1.74