Hub : Traits :

High cholesterol (Self-reported)

390 significantly associated models · 140 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 25475418 27895517 5 2 5.4e-10 1.8e-07 4.0e-01 97 MTFR1L PIGV
2 1 61510619 64021096 4 1 2.2e-22 4.9e-23 1.0e+00 100 DOCK7
3 1 108854166 111016796 12 12 4.5e-80 5.1e-80 1.0e+00 100 AC000032.2 AMIGO1 ATXN7L2 CELSR2 GPSM2 GSTM1 PSRC1 SORT1
4 2 20529948 21958745 1 1 2.1e-74 1.5e-76 1.0e+00 100 APOB
5 2 26624843 28607344 16 7 6.1e-23 3.2e-36 NaN NaN EIF2B4 FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1
6 2 43342098 44759941 1 1 3.1e-11 3.8e-39 7.3e-33 17 ABCG5
7 2 202434393 204433184 4 1 9.8e-12 1.0e-10 4.3e-02 90 NOP58
8 3 11829474 13321852 2 2 2.2e-10 1.6e-09 3.2e-04 64 MKRN2 TSEN2
9 5 73626450 75704085 7 2 5.3e-29 4.0e-38 3.1e-10 76 COL4A3BP POLK
10 5 155651738 157087764 1 1 1.5e-17 5.2e-19 6.6e-03 91 TIMD4
11 6 159820779 161571560 3 3 5.5e-14 1.0e-23 3.8e-18 25 RP11-288H12.3 SLC22A3
12 7 43885849 45318389 3 2 1.0e-12 1.2e-13 4.7e-02 93 DDX56 NPC1L1
13 8 19064892 20521138 1 1 1.4e-10 1.1e-13 8.1e-05 72 LPL
14 8 58628032 60056887 1 1 1.7e-07 1.6e-11 3.4e-06 53 UBXN2B
15 9 106846396 108380721 1 1 4.1e-10 2.4e-14 9.9e-06 66 ABCA1
16 11 60965461 62380732 1 1 2.4e-07 1.6e-05 8.1e-03 62 RAB3IL1
17 11 100168289 101559718 1 1 1.5e-07 1.5e-06 9.6e-01 100 TMEM133
18 11 106500377 108027561 1 1 2.6e-07 5.7e-05 2.6e-01 92 CWF19L2
19 11 115817454 117853613 8 8 1.5e-46 3.8e-51 NaN NaN AP000770.1 PAFAH1B2 PCSK7 SIDT2 ZNF259
20 12 52857365 54270228 1 1 3.6e-07 1.8e-05 4.6e-05 10 CSAD
21 12 120722064 122131468 1 1 6.5e-10 2.3e-13 1.9e-05 66 HNF1A
22 13 32275990 33700374 1 1 1.1e-07 9.6e-06 1.9e-01 91 N4BP2L1
23 16 29905882 31281751 1 1 2.4e-07 1.9e-07 2.9e-03 67 ZNF785
24 16 71070698 72845749 9 10 5.2e-18 9.3e-18 1.0e+00 100 AP1G1 DHODH DHX38 HP HPR IST1 RP11-498D10.5
25 17 44788310 46874272 9 2 1.3e-11 4.3e-09 9.6e-02 92 AC002558.1 CBX1
26 17 73059836 74697386 9 1 3.1e-09 1.2e-10 3.5e-03 79 MRPL38
27 19 9982334 12196190 11 9 2.8e-29 2.8e-100 1.2e-29 72 C19orf80 EPOR LDLR SLC44A2 SMARCA4 TSPAN16
28 19 18333894 20451172 5 2 1.1e-15 3.6e-19 2.9e-05 78 ATP13A1
29 19 44190626 46098885 7 6 1.1e-18 4.7e-145 6.5e-116 20 BCAM CEACAM19 PVRL2 TOMM40 ZNF229 ZNF285
30 19 48464978 50108983 6 1 3.6e-15 3.4e-16 2.0e-02 92 RASIP1
31 20 39270768 40683594 1 1 2.3e-09 4.5e-10 7.8e-04 71 LPIN3
32 20 61800907 62912463 5 1 1.4e-12 3.2e-12 3.0e-01 98 RGS19

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 5.98 5 4 12.1 -0.93 2.2e-02 BCAM CEACAM19 TOMM40 ZNF229 ZNF285
Alzheimer’s Disease (in father) 2.76 4 2 6.1 -1.00 2.7e-03 CEACAM19 TOMM40 ZNF229 ZNF285
Alzheimer’s Disease (including proxy) 10.97 6 5 15.2 -0.85 3.3e-02 BCAM CEACAM19 TOMM40 ZNF229 ZNF285 ZNF785
Crohns Disease (2017) 1.64 6 1 3.0 0.72 1.0e-01 FNDC4 GTF3C2 KRTCAP3 NRBP1 RASIP1 TIMD4
Irritable Bowel Disease (IBD) 1.48 4 0 0.0 0.99 6.3e-03 GTF3C2 KRTCAP3 NRBP1 RASIP1
Ulcerative Colitis (UC) 1.18 1 0 0.0 0.00 1.0e+00 RGS19
Reaction Time 1.04 2 0 0.0 0.00 1.0e+00 SLC44A2 SMARCA4
Verbal and Numeric Reasoning (VNR) 1.11 1 0 0.0 0.00 1.0e+00 ATXN7L2
Breast Cancer 1.15 2 1 3.0 0.00 1.0e+00 ATP13A1 RGS19
Ovarian Cancer 1.46 1 0 0.0 0.00 1.0e+00 PAFAH1B2
Body Mass Index (BMI) (2010) 1.63 1 0 0.0 0.00 1.0e+00 POLK
Coronary Artery Disease (CAD) 5.07 8 2 6.1 -0.96 9.0e-06 AC000032.2 ATXN7L2 CELSR2 EPOR PSRC1 SLC22A3 SMARCA4 ZNF259
Crohns Disease (2012) 1.20 3 0 0.0 0.00 1.0e+00 DOCK7 RASIP1 TIMD4
Fasting Glucose 4.19 7 6 18.2 0.99 1.4e-05 EIF2B4 FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1
HDL Cholesterol 6.99 12 4 12.1 0.31 3.3e-01 ABCA1 AC002558.1 APOB CELSR2 GPSM2 LPL PCSK7 PIGV RAB3IL1 SIDT2 TOMM40 ZNF259
LDL Cholesterol 47.50 52 38 115.2 -0.95 2.4e-34 ABCA1 ABCG5 AC000032.2 AMIGO1 AP000770.1 AP1G1 APOB ATP13A1 ATXN7L2 BCAM C19orf80 CBX1 CEACAM19 CELSR2 COL4A3BP DDX56 DHX38 DOCK7 EPOR GPSM2 GSTM1 HNF1A HP HPR IST1 LDLR LPIN3 MKRN2 MTFR1L N4BP2L1 NPC1L1 PAFAH1B2 PCSK7 PIGV POLK PSRC1 PVRL2 RAB3IL1 RASIP1 RP11-288H12.3 SIDT2 SLC22A3 SLC44A2 SMARCA4 SORT1 TIMD4 TOMM40 TSEN2 TSPAN16 ZNF229 ZNF259 ZNF285
Rheumatoid Arthritis 1.39 1 0 0.0 0.00 1.0e+00 RGS19
Schizophrenia 1.00 1 0 0.0 0.00 1.0e+00 ATP13A1
Triglycerides 29.73 19 17 51.5 -0.87 7.3e-08 AP000770.1 APOB ATP13A1 DOCK7 EIF2B4 FNDC4 FTH1P3 GTF3C2 HPR IFT172 KRTCAP3 LPL PAFAH1B2 PCSK7 RP11-498D10.5 SIDT2 SLC22A3 TIMD4 ZNF259
Blood Eosinophil Count 1.17 15 9 27.3 0.24 3.6e-01 AC002558.1 ATP13A1 BCAM EPOR FNDC4 HNF1A LPL MRPL38 PAFAH1B2 PIGV PVRL2 SMARCA4 TOMM40 TSEN2 ZNF259
Blood Platelet Count 3.81 31 28 84.8 -0.01 9.4e-01 AC002558.1 AP000770.1 ATP13A1 COL4A3BP DDX56 DOCK7 EIF2B4 FNDC4 FTH1P3 GSTM1 GTF3C2 HNF1A HPR IFT172 IST1 KRTCAP3 MTFR1L NRBP1 PAFAH1B2 PCSK7 PIGV POLK RAB3IL1 RASIP1 SIDT2 SLC44A2 TIMD4 TOMM40 TSEN2 ZNF259 ZNF285
Blood Red Count 0.88 14 9 27.3 -0.39 1.7e-01 AP1G1 ATP13A1 CBX1 DHODH DHX38 FNDC4 HNF1A HPR IST1 LPIN3 MKRN2 PCSK7 SORT1 TIMD4
Blood White Count 2.30 15 9 27.3 -0.47 6.3e-02 ATP13A1 CBX1 EIF2B4 FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 MRPL38 NRBP1 PAFAH1B2 SMARCA4 TIMD4 TMEM133 TSEN2
Heel T-Score 0.75 8 3 9.1 0.80 1.8e-02 ATP13A1 ATXN7L2 CELSR2 MTFR1L PCSK7 TMEM133 TSEN2 ZNF785
BMI 1.61 14 6 18.2 0.48 5.7e-02 AC000032.2 AMIGO1 ATXN7L2 COL4A3BP DHX38 FNDC4 HP HPR MRPL38 NOP58 POLK RGS19 RP11-498D10.5 SLC22A3
Height 1.34 31 24 72.7 0.72 4.9e-07 ABCG5 AC002558.1 AP1G1 ATP13A1 CBX1 CELSR2 DHX38 EIF2B4 EPOR FNDC4 FTH1P3 GPSM2 GTF3C2 IFT172 KRTCAP3 LPL MKRN2 NOP58 NRBP1 PAFAH1B2 PIGV PSRC1 RAB3IL1 RASIP1 SLC22A3 SLC44A2 SMARCA4 TMEM133 TSEN2 ZNF229 ZNF259
Waist Hip Ratio (WHR) 2.02 11 7 21.2 -0.79 1.3e-03 ABCA1 ATP13A1 CSAD LPIN3 LPL MKRN2 RASIP1 RGS19 SLC22A3 SMARCA4 TSEN2
Systolic Blood Pressure 3.01 21 10 30.3 -0.83 6.2e-07 ABCG5 AC002558.1 AP1G1 CWF19L2 EIF2B4 EPOR FTH1P3 GTF3C2 IFT172 KRTCAP3 MRPL38 NRBP1 PAFAH1B2 PCSK7 PIGV RASIP1 RGS19 SIDT2 SMARCA4 TMEM133 TOMM40
Smoking Status 0.93 1 0 0.0 0.00 1.0e+00 DHX38
Allergy or Eczema 1.13 6 0 0.0 -0.81 5.1e-02 GTF3C2 HNF1A IFT172 KRTCAP3 NRBP1 PVRL2
Cardiovascular Disease 8.85 54 34 103.0 -0.94 3.9e-31 ABCG5 AC000032.2 AC002558.1 AP000770.1 AP1G1 APOB ATXN7L2 BCAM CBX1 CELSR2 COL4A3BP CWF19L2 DDX56 DHX38 DOCK7 EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 HNF1A HP HPR IFT172 IST1 KRTCAP3 LPL MRPL38 NOP58 NPC1L1 NRBP1 PAFAH1B2 PCSK7 PIGV PSRC1 PVRL2 RASIP1 RGS19 RP11-288H12.3 RP11-498D10.5 SIDT2 SLC22A3 SMARCA4 SORT1 TIMD4 TMEM133 TOMM40 TSEN2 TSPAN16 UBXN2B ZNF229 ZNF259 ZNF285 ZNF785
Hypothyroidism (self reported) 1.11 3 1 3.0 0.00 1.0e+00 AC002558.1 DDX56 RASIP1
Respiratory disease 1.10 1 0 0.0 0.00 1.0e+00 MRPL38
Type 2 Diabetes (T2D) 2.66 8 3 9.1 0.85 7.5e-03 ATP13A1 FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 LPL NRBP1
Lung FEV1/FVC ratio 0.90 5 3 9.1 -0.36 4.8e-01 CELSR2 PSRC1 RASIP1 TMEM133 TSPAN16
Lung FVC 1.02 6 5 15.2 0.99 1.6e-04 NOP58 PCSK7 RAB3IL1 RGS19 SIDT2 ZNF785
Neuroticism 0.86 1 0 0.0 0.00 1.0e+00 AMIGO1
Chronotype (morning person) 1.22 4 0 0.0 -0.01 9.9e-01 AMIGO1 DHX38 SLC44A2 ZNF285
Hair Pigment 0.34 16 9 27.3 -0.77 5.2e-05 DHX38 EPOR FTH1P3 GTF3C2 HP IFT172 KRTCAP3 MKRN2 NRBP1 PCSK7 PIGV RGS19 SIDT2 SLC44A2 SMARCA4 TMEM133
Tanning 0.36 7 3 9.1 0.99 3.6e-05 DHX38 FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1
Hand grip strength (left) 1.18 2 0 0.0 0.00 1.0e+00 ABCG5 DHX38
Number of treatments/medications taken 3.80 9 1 3.0 0.93 4.1e-05 ABCG5 CELSR2 CWF19L2 DHX38 GTF3C2 KRTCAP3 NOP58 NRBP1 TMEM133
Average weekly spirits intake 0.99 1 0 0.0 0.00 1.0e+00 RASIP1
Sensitivity / hurt feelings 0.98 1 0 0.0 0.00 1.0e+00 ATP13A1
Relative age of first facial hair 1.08 2 0 0.0 0.00 1.0e+00 FNDC4 NRBP1
Ever used hormone-replacement therapy (HRT) 1.16 1 0 0.0 0.00 1.0e+00 KRTCAP3
Systolic blood pressure, automated reading 2.14 8 3 9.1 0.88 3.5e-03 AC002558.1 CWF19L2 MRPL38 PIGV RASIP1 RGS19 SMARCA4 TMEM133
Angina 4.23 8 1 3.0 0.97 2.9e-06 ABCG5 ATXN7L2 C19orf80 CELSR2 PSRC1 RGS19 SLC22A3 TMEM133
Medication: Metformin 2.11 3 0 0.0 0.00 1.0e+00 GTF3C2 IFT172 NRBP1
Diabetes (mother) 1.80 1 0 0.0 0.00 1.0e+00 ATP13A1
Impedance of leg (right) 1.42 14 6 18.2 0.53 4.2e-02 AC000032.2 AC002558.1 AMIGO1 ATP13A1 ATXN7L2 CBX1 COL4A3BP FNDC4 MTFR1L NRBP1 POLK RGS19 SORT1 TMEM133
Leg fat-free mass (left) 1.91 17 11 33.3 -0.86 4.8e-06 AC000032.2 ATP13A1 ATXN7L2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 MRPL38 NRBP1 POLK SLC22A3 SLC44A2 SMARCA4 TMEM133
Trunk fat percentage 1.25 10 2 6.1 -0.38 2.7e-01 BCAM COL4A3BP DHX38 GSTM1 HPR MRPL38 NOP58 POLK SLC22A3 ZNF785
Hand grip strength (right) 1.13 3 1 3.0 0.00 1.0e+00 ABCG5 CWF19L2 DHX38
Age when periods started (menarche) 0.91 3 0 0.0 0.00 1.0e+00 HNF1A NOP58 RASIP1
High blood pressure 2.97 12 5 15.2 0.92 2.6e-05 ABCG5 AC002558.1 CBX1 CWF19L2 MRPL38 NPC1L1 PCSK7 PIGV RASIP1 RGS19 SIDT2 TMEM133
Hayfever, allergic rhinitis or eczema 1.22 5 0 0.0 0.99 5.7e-04 GTF3C2 IFT172 KRTCAP3 NRBP1 PVRL2
Medication: Atenolol 2.45 1 0 0.0 0.00 1.0e+00 TMEM133
Medication: Levothyroxine sodium 1.10 1 0 0.0 0.00 1.0e+00 AC002558.1
Sitting height 1.15 14 8 24.2 -0.58 3.1e-02 AMIGO1 ATP13A1 EIF2B4 FNDC4 FTH1P3 GTF3C2 HPR IFT172 KRTCAP3 NRBP1 PIGV RASIP1 SLC22A3 SLC44A2
High blood pressure (mother) 1.84 2 1 3.0 0.00 1.0e+00 PIGV TMEM133
Body mass index (BMI) 1.35 5 3 9.1 -0.47 4.2e-01 COL4A3BP DHX38 GSTM1 HPR POLK
Impedance of leg (left) 1.47 14 7 21.2 0.52 4.7e-02 AC000032.2 AMIGO1 ATP13A1 ATXN7L2 CBX1 COL4A3BP EIF2B4 FNDC4 MTFR1L NRBP1 POLK RGS19 SORT1 TMEM133
Leg predicted mass (left) 1.92 17 11 33.3 -0.86 4.6e-06 AC000032.2 ATP13A1 ATXN7L2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 MRPL38 NRBP1 POLK SLC22A3 SLC44A2 SMARCA4 TMEM133
Trunk fat mass 1.37 8 4 12.1 -0.50 2.1e-01 COL4A3BP DHX38 GSTM1 HPR IFT172 MRPL38 POLK SLC22A3
Waist circumference 1.35 6 2 6.1 -0.43 4.0e-01 COL4A3BP DHX38 HP HPR IFT172 POLK
Had menopause 2.57 5 5 15.2 -0.99 1.3e-03 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1
Forced vital capacity (FVC) 1.23 7 2 6.1 -0.98 8.1e-05 ABCG5 CSAD NOP58 SLC44A2 SMARCA4 TMEM133 ZNF785
Qualifications: None of the above 0.87 1 0 0.0 0.00 1.0e+00 SORT1
Mouth/teeth dental problems 0.97 1 0 0.0 0.00 1.0e+00 RASIP1
Heart attack 3.07 4 1 3.0 0.99 1.9e-03 C19orf80 CELSR2 PSRC1 SLC22A3
Allergy 0.99 1 0 0.0 0.00 1.0e+00 PVRL2
Diabetes (self-reported) 2.47 6 2 6.1 -1.00 1.4e-05 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1 POLK
Medication: Ramipril 2.46 1 1 3.0 0.00 1.0e+00 TMEM133
Medication: Simvastatin 17.04 50 22 66.7 0.99 9.3e-48 ABCG5 AC000032.2 AMIGO1 AP1G1 APOB ATP13A1 ATXN7L2 BCAM C19orf80 CBX1 CEACAM19 CELSR2 COL4A3BP DHX38 DOCK7 EIF2B4 EPOR FNDC4 FTH1P3 GPSM2 GSTM1 HP HPR IST1 LDLR LPL NOP58 NPC1L1 NRBP1 PAFAH1B2 PCSK7 PIGV POLK PSRC1 PVRL2 RAB3IL1 RASIP1 RGS19 RP11-498D10.5 SIDT2 SLC22A3 SLC44A2 SMARCA4 SORT1 TIMD4 TMEM133 TOMM40 TSPAN16 ZNF229 ZNF259
Illnesses of siblings 2.32 1 0 0.0 0.00 1.0e+00 TMEM133
Weight 1.72 17 7 21.2 -0.74 4.1e-04 AC000032.2 ATXN7L2 COL4A3BP DHX38 EPOR FNDC4 GSTM1 GTF3C2 HPR IFT172 MRPL38 NRBP1 POLK RASIP1 SLC22A3 SLC44A2 SMARCA4
Impedance of arm (right) 1.42 12 5 15.2 0.67 1.7e-02 ATXN7L2 CBX1 COL4A3BP EIF2B4 FNDC4 FTH1P3 GTF3C2 NRBP1 POLK RGS19 SORT1 UBXN2B
Arm fat percentage (right) 1.38 8 5 15.2 -0.30 4.3e-01 COL4A3BP DHX38 GSTM1 HP HPR MRPL38 NOP58 POLK
Trunk fat-free mass 2.16 19 14 42.4 -0.89 7.9e-08 AC000032.2 AC002558.1 ATXN7L2 CELSR2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1 POLK RASIP1 SLC22A3 SLC44A2 SMARCA4 TMEM133
Hip circumference 1.75 14 6 18.2 -0.73 3.1e-03 ABCA1 COL4A3BP FNDC4 GSTM1 HPR IFT172 MRPL38 POLK RASIP1 RGS19 SLC22A3 SLC44A2 SMARCA4 TSEN2
Alcohol intake versus 10 years previously 2.45 5 1 3.0 0.33 5.9e-01 AMIGO1 FNDC4 GTF3C2 NRBP1 RASIP1
Father's age at death 2.02 2 0 0.0 0.00 1.0e+00 ATXN7L2 CELSR2
Forced expiratory volume in 1-second (FEV1) 1.29 6 1 3.0 -0.94 1.8e-03 DHX38 EPOR SLC44A2 SMARCA4 TMEM133 ZNF785
Pulse rate 1.88 3 0 0.0 0.00 1.0e+00 FNDC4 GTF3C2 NRBP1
Mouth/teeth dental problems: Dentures 0.82 2 1 3.0 0.00 1.0e+00 FNDC4 RASIP1
Asthma 1.20 2 0 0.0 0.00 1.0e+00 MRPL38 SMARCA4
Medication: Cholesterol lowering 21.36 56 31 93.9 0.99 5.0e-53 ABCG5 AC000032.2 AMIGO1 AP000770.1 AP1G1 APOB ATP13A1 ATXN7L2 BCAM C19orf80 CBX1 CELSR2 COL4A3BP DHX38 DOCK7 EIF2B4 EPOR FNDC4 FTH1P3 GPSM2 GSTM1 GTF3C2 HNF1A HP HPR IFT172 IST1 KRTCAP3 LDLR LPIN3 LPL NOP58 NPC1L1 NRBP1 PAFAH1B2 PCSK7 PIGV PSRC1 PVRL2 RASIP1 RGS19 RP11-288H12.3 RP11-498D10.5 SIDT2 SLC22A3 SLC44A2 SMARCA4 SORT1 TIMD4 TMEM133 TOMM40 TSPAN16 UBXN2B ZNF229 ZNF259 ZNF785
Illnesses of mother 2.28 1 0 0.0 0.00 1.0e+00 TMEM133
Forced expiratory volume in 1-second (FEV1), Best measure 1.24 6 2 6.1 -0.95 8.3e-04 ABCG5 EPOR SLC44A2 SMARCA4 TMEM133 ZNF785
Impedance of arm (left) 1.41 12 5 15.2 0.69 1.3e-02 ATXN7L2 CBX1 COL4A3BP EIF2B4 FNDC4 FTH1P3 GTF3C2 NRBP1 POLK RGS19 SORT1 UBXN2B
Arm fat mass (right) 1.52 7 4 12.1 -0.48 2.8e-01 COL4A3BP DHX38 GSTM1 HPR MRPL38 POLK SLC22A3
Trunk predicted mass 2.17 19 15 45.5 -0.89 7.7e-08 AC000032.2 AC002558.1 ATXN7L2 CELSR2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1 POLK RASIP1 SLC22A3 SLC44A2 SMARCA4 TMEM133
Standing height 1.39 23 17 51.5 -0.71 5.6e-05 ABCG5 AP1G1 ATP13A1 CBX1 CELSR2 DHX38 EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 MKRN2 NOP58 NRBP1 PIGV PSRC1 RASIP1 SLC22A3 SLC44A2 SMARCA4 TSEN2
Birth weight of first child 1.76 2 0 0.0 0.00 1.0e+00 ATP13A1 RGS19
Peak expiratory flow (PEF) 1.07 1 0 0.0 0.00 1.0e+00 RASIP1
Blood clot in the leg (DVT) 1.29 1 0 0.0 0.00 1.0e+00 SLC44A2
Medication for cholesterol, blood pressure or diabetes 8.94 25 10 30.3 -0.96 5.1e-16 ABCG5 AC002558.1 AP000770.1 APOB ATXN7L2 C19orf80 CELSR2 CSAD CWF19L2 DHX38 EPOR HPR NPC1L1 NRBP1 PAFAH1B2 PCSK7 PSRC1 RASIP1 RGS19 SIDT2 SMARCA4 SORT1 TMEM133 TOMM40 ZNF259
Gout (self-reported) 4.39 7 7 21.2 0.99 3.6e-06 EIF2B4 FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1
Medication: Amlodipine 1.27 1 1 3.0 0.00 1.0e+00 TMEM133
Birth weight 0.99 1 0 0.0 0.00 1.0e+00 RASIP1
Chronic bronchitis/emphysema (mother) 1.33 1 0 0.0 0.00 1.0e+00 BCAM
High blood pressure (siblings) 2.11 2 0 0.0 0.00 1.0e+00 TMEM133 ZNF785
Forced vital capacity (FVC), Best measure 1.30 6 3 9.1 -0.94 1.7e-03 ABCG5 EPOR NOP58 SLC44A2 SMARCA4 ZNF785
Body fat percentage 1.32 9 3 9.1 -0.33 3.5e-01 BCAM COL4A3BP DHX38 GSTM1 HPR MRPL38 NOP58 POLK ZNF785
Leg fat percentage (right) 1.23 6 2 6.1 -0.41 4.2e-01 COL4A3BP DHX38 GSTM1 NOP58 POLK ZNF785
Arm fat-free mass (right) 2.12 17 13 39.4 -0.90 3.5e-07 AC000032.2 ATXN7L2 CELSR2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1 POLK RASIP1 SLC22A3 SLC44A2 SMARCA4
Comparative body size at age 10 1.32 5 1 3.0 -0.77 1.2e-01 AC000032.2 ATP13A1 ATXN7L2 POLK RASIP1
Health satisfaction 1.32 1 0 0.0 0.00 1.0e+00 GPSM2
Qualifications: College or University degree 0.77 1 0 0.0 0.00 1.0e+00 ATXN7L2
Medication: Blood pressure 2.61 6 1 3.0 0.93 8.0e-03 ABCG5 CSAD CWF19L2 NPC1L1 RGS19 TMEM133
Angina (self-reported) 4.49 6 1 3.0 0.98 1.9e-06 ATXN7L2 C19orf80 CELSR2 PSRC1 RGS19 SLC22A3
Medication: Allopurinol 3.56 8 6 18.2 0.99 1.2e-06 EIF2B4 FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1 PIGV
Heart disease (mother) 2.55 2 0 0.0 0.00 1.0e+00 ABCG5 SLC22A3
Whole body fat mass 1.41 7 4 12.1 -0.47 2.9e-01 COL4A3BP DHX38 GSTM1 HPR MRPL38 POLK SLC22A3
Leg fat mass (right) 1.44 7 2 6.1 -0.50 2.5e-01 COL4A3BP DHX38 GSTM1 HPR MRPL38 POLK SLC22A3
Arm predicted mass (right) 2.06 16 11 33.3 -0.90 1.1e-06 ATXN7L2 CELSR2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1 POLK RASIP1 SLC22A3 SLC44A2 SMARCA4
Pulse rate, automated reading 2.36 9 8 24.2 0.89 1.5e-03 EIF2B4 FNDC4 FTH1P3 GTF3C2 HP IFT172 KRTCAP3 NRBP1 ZNF785
Alcohol intake frequency. 3.21 8 8 24.2 0.82 1.3e-02 EIF2B4 FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1 RASIP1
Comparative height size at age 10 1.59 17 7 21.2 -0.57 1.6e-02 AP1G1 ATP13A1 CELSR2 DHX38 FNDC4 FTH1P3 GTF3C2 HNF1A IFT172 KRTCAP3 MKRN2 NRBP1 PAFAH1B2 PIGV RASIP1 SLC22A3 SLC44A2
Overall health rating 1.53 4 0 0.0 0.94 5.8e-02 AP000770.1 FTH1P3 NRBP1 ZNF785
Medication: Aspirin 3.76 4 1 3.0 0.95 1.3e-02 ATXN7L2 CELSR2 RGS19 SLC22A3
Knee pain experienced in last month 1.24 1 0 0.0 0.00 1.0e+00 SLC44A2
Hypertension (Self-reported) 2.98 13 6 18.2 0.92 9.6e-06 ABCG5 AC002558.1 CBX1 CWF19L2 DHX38 MRPL38 NPC1L1 PIGV RASIP1 RGS19 SIDT2 TMEM133 ZNF785
Illnesses of father: Heart disease 5.57 12 3 9.1 0.95 3.3e-08 ABCG5 CELSR2 EPOR LPL NPC1L1 PSRC1 RGS19 RP11-288H12.3 SLC22A3 SLC44A2 SMARCA4 SORT1
Forced expiratory volume in 1-second (FEV1), predicted 1.15 1 0 0.0 0.00 1.0e+00 SLC44A2
Whole body fat-free mass 2.10 21 13 39.4 -0.85 4.3e-07 AC000032.2 AC002558.1 ATP13A1 ATXN7L2 CELSR2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 MTFR1L NRBP1 POLK RASIP1 SLC22A3 SLC44A2 SMARCA4 TMEM133
Leg fat-free mass (right) 1.92 18 10 30.3 -0.81 1.2e-05 AC000032.2 ATP13A1 ATXN7L2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 MRPL38 MTFR1L NRBP1 POLK SLC22A3 SLC44A2 SMARCA4 TMEM133
Arm fat percentage (left) 1.36 7 6 18.2 -0.31 4.6e-01 COL4A3BP DHX38 GSTM1 HPR MRPL38 NOP58 POLK
Mood swings 1.08 1 0 0.0 0.00 1.0e+00 AMIGO1
Diabetes diagnosed by doctor 2.62 7 3 9.1 -0.99 2.5e-05 ATP13A1 FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1
Medication for cholesterol 6.02 16 2 6.1 -0.92 7.1e-08 ATXN7L2 CELSR2 CWF19L2 DHX38 DOCK7 EIF2B4 FNDC4 GPSM2 HP NRBP1 PAFAH1B2 PCSK7 PIGV RASIP1 SIDT2 TMEM133
Back pain experienced in last month 1.44 1 0 0.0 0.00 1.0e+00 APOB
Asthma (self-reported) 1.15 1 0 0.0 0.00 1.0e+00 MRPL38
Osteoarthritis (self-reported) 1.81 2 0 0.0 0.00 1.0e+00 SLC44A2 SMARCA4
Medication: Aspirin 3.83 5 1 3.0 0.96 2.0e-03 ATXN7L2 CELSR2 EPOR RGS19 SLC22A3
Illnesses of father: None of the above (group 1) 2.37 3 0 0.0 0.00 1.0e+00 ABCG5 SLC22A3 SLC44A2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.26 1 0 0.0 0.00 1.0e+00 ZNF785
Whole body water mass 2.09 21 12 36.4 -0.85 5.1e-07 AC000032.2 AC002558.1 ATP13A1 ATXN7L2 CELSR2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 MTFR1L NRBP1 POLK RASIP1 SLC22A3 SLC44A2 SMARCA4 TMEM133
Leg predicted mass (right) 1.93 18 10 30.3 -0.82 1.1e-05 AC000032.2 ATP13A1 ATXN7L2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 MRPL38 MTFR1L NRBP1 POLK SLC22A3 SLC44A2 SMARCA4 TMEM133
Arm fat mass (left) 1.49 7 3 9.1 -0.46 2.9e-01 COL4A3BP DHX38 GSTM1 HPR MRPL38 POLK SLC22A3
Number of self-reported non-cancer illnesses 3.67 8 0 0.0 0.99 7.0e-06 CWF19L2 DHX38 FNDC4 GTF3C2 IFT172 NRBP1 RASIP1 RGS19
Medication: Blood pressure 2.90 7 3 9.1 0.94 6.3e-04 CWF19L2 DHX38 HP PIGV RASIP1 RGS19 TMEM133
Medication: Bendroflumethiazide 1.84 4 1 3.0 0.99 1.4e-02 CWF19L2 PIGV RASIP1 TMEM133
Medication: Lisinopril 1.36 2 0 0.0 0.00 1.0e+00 AC002558.1 TMEM133
Medication: Atorvastatin 15.32 37 15 45.5 0.99 3.6e-32 ABCA1 ABCG5 AC000032.2 AC002558.1 AP000770.1 AP1G1 APOB ATP13A1 ATXN7L2 BCAM C19orf80 CELSR2 COL4A3BP DOCK7 EPOR FNDC4 FTH1P3 GPSM2 GTF3C2 HPR IFT172 KRTCAP3 LPIN3 NRBP1 PAFAH1B2 PCSK7 PSRC1 PVRL2 RASIP1 SLC22A3 SMARCA4 TOMM40 UBXN2B ZNF229 ZNF259 ZNF285 ZNF785
Illnesses of father: High blood pressure 1.48 2 0 0.0 0.00 1.0e+00 ABCG5 TMEM133
Basal metabolic rate 1.98 18 11 33.3 -0.85 2.3e-06 AC000032.2 ATP13A1 ATXN7L2 CELSR2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1 POLK RASIP1 SLC22A3 SLC44A2 SMARCA4
Leg fat percentage (left) 1.20 7 2 6.1 -0.41 3.6e-01 BCAM COL4A3BP DHX38 GSTM1 NOP58 POLK ZNF785
Arm fat-free mass (left) 2.00 17 12 36.4 -0.89 5.4e-07 AC000032.2 ATXN7L2 CELSR2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1 POLK RASIP1 SLC22A3 SLC44A2 SMARCA4
Irritability 0.98 2 1 3.0 0.00 1.0e+00 ATP13A1 ZNF785
Diastolic blood pressure, automated reading 1.60 4 1 3.0 0.56 4.4e-01 C19orf80 PIGV TMEM133 ZNF785
Vascular/heart problems diagnosed by doctor 3.14 11 4 12.1 -0.92 6.2e-05 ABCG5 AC002558.1 CBX1 CWF19L2 MRPL38 NPC1L1 PIGV RASIP1 RGS19 SIDT2 TMEM133
Cholesterol lowering medication 17.88 49 26 78.8 0.99 3.0e-52 ABCA1 ABCG5 AMIGO1 AP000770.1 AP1G1 APOB ATXN7L2 BCAM C19orf80 CBX1 CELSR2 COL4A3BP DDX56 DHX38 DOCK7 EPOR FNDC4 FTH1P3 GPSM2 GTF3C2 HNF1A HPR IFT172 LDLR LPIN3 LPL N4BP2L1 NOP58 NPC1L1 NRBP1 PAFAH1B2 PCSK7 PIGV POLK PSRC1 PVRL2 RAB3IL1 RASIP1 RGS19 SIDT2 SLC22A3 SMARCA4 TIMD4 TOMM40 TSEN2 TSPAN16 ZNF229 ZNF259 ZNF285
Pain experienced in last month 1.71 1 0 0.0 0.00 1.0e+00 DHX38
Heart attack/myocardial infarction (self-reported) 2.97 2 1 3.0 0.00 1.0e+00 CELSR2 SLC22A3
Deep venous thrombosis (DVT) (self-reported) 1.15 1 0 0.0 0.00 1.0e+00 SLC44A2
Heart disease (siblings) 2.90 2 1 3.0 0.00 1.0e+00 SLC22A3 SMARCA4
Impedance of whole body 1.51 15 8 24.2 0.67 6.1e-03 AMIGO1 ATP13A1 ATXN7L2 CBX1 COL4A3BP EIF2B4 FNDC4 FTH1P3 GTF3C2 MTFR1L NRBP1 POLK RGS19 SORT1 TMEM133
Leg fat mass (left) 1.43 7 2 6.1 -0.51 2.5e-01 COL4A3BP DHX38 GSTM1 HPR MRPL38 POLK SLC22A3
Arm predicted mass (left) 2.05 17 12 36.4 -0.90 2.8e-07 AC000032.2 ATXN7L2 CELSR2 COL4A3BP EIF2B4 EPOR FNDC4 FTH1P3 GTF3C2 IFT172 KRTCAP3 NRBP1 POLK RASIP1 SLC22A3 SLC44A2 SMARCA4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 7 0.201 1.75
GTEx Adipose Visceral Omentum 8 0.393 1.79
GTEx Adrenal Gland 6 0.412 1.78
GTEx Artery Aorta 10 0.336 1.80
GTEx Artery Coronary 2 0.169 1.73
GTEx Artery Tibial 16 0.425 1.83
GTEx Brain Caudate basal ganglia 2 0.217 1.57
GTEx Brain Cerebellar Hemisphere 6 0.403 1.75
GTEx Brain Cerebellum 4 0.202 1.73
GTEx Brain Cortex 2 0.193 1.75
GTEx Brain Frontal Cortex BA9 5 0.541 1.81
GTEx Brain Hippocampus 1 0.191 1.63
GTEx Brain Hypothalamus 1 0.169 1.54
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.64
GTEx Brain Putamen basal ganglia 0 0.000 1.58
GTEx Breast Mammary Tissue 0 0.000 1.60
GTEx Breast Mammary Tissue (Male) 4 0.335 1.64
GTEx Breast Mammary Tissue (Female) 3 0.182 1.66
GTEx Cells EBV-transformed lymphocytes 4 0.281 1.67
GTEx Cells Transformed fibroblasts 19 0.452 1.83
GTEx Colon Sigmoid 4 0.274 1.71
GTEx Colon Transverse 4 0.194 1.74
GTEx Esophagus Gastroesophageal Junction 5 0.346 1.66
GTEx Esophagus Mucosa 16 0.482 1.93
GTEx Esophagus Muscularis 12 0.371 1.78
GTEx Heart Atrial Appendage 3 0.190 1.67
GTEx Heart Left Ventricle 3 0.196 1.72
GTEx Liver 5 0.697 2.38
GTEx Lung 4 0.139 1.67
GTEx Muscle Skeletal 11 0.381 1.86
GTEx Nerve Tibial 9 0.208 1.70
GTEx Ovary 4 0.441 1.77
GTEx Pancreas 3 0.184 1.70
GTEx Pituitary 5 0.448 1.74
GTEx Prostate 3 0.359 1.73
GTEx Skin Not Sun Exposed Suprapubic 10 0.407 1.80
GTEx Skin Sun Exposed Lower leg 19 0.522 1.85
GTEx Small Intestine Terminal Ileum 1 0.217 1.84
GTEx Spleen 6 0.425 1.82
GTEx Stomach 7 0.481 1.87
GTEx Testis 6 0.190 1.74
GTEx Thyroid 10 0.250 1.77
GTEx Uterus 0 0.000 1.56
GTEx Vagina 2 0.315 1.81
GTEx Whole Blood 9 0.452 2.03
METSIM Adipose 17 0.369 1.69
NTR Blood 8 0.333 1.67
ROSMAP Brain Pre-frontal Cortex 19 0.433 1.90
YFS Blood 15 0.325 1.77
CommonMind Brain Pre-frontal Cortex 26 0.484 1.89
TCGA Breast Tumor 3 0.391 1.68
TCGA Breast Normal 19 0.452 1.65
TCGA Ovarian Tumor 11 0.376 1.65
TCGA Prostate Tumor 11 0.318 1.64