TWAS hub - N4BP2L1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.397	0.047	0.0e+00	0.264	0.274	0.314	0.254	0.310	4.3e-32	2.2e-33	7.1e-39	9.4e-31	2.3e-38
2	GTEx	Prostate	0.290	0.111	5.4e-03	-0.010	NA	0.032	NA	0.017	7.0e-01	NA	5.3e-02	NA	1.2e-01
3	GTEx	Skin Sun Exposed Lower leg	0.149	0.041	8.5e-05	0.011	NA	0.036	NA	0.030	3.6e-02	NA	5.9e-04	NA	1.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
LDL Cholesterol	11.8	18.6	27.6	-5.3	2.6	4.6
High cholesterol (Self-reported)	7.0	12.4	28.2	-5.3	-0.7	2.9
Cholesterol lowering medication	5.1	7.5	16.8	-4.1	0.1	2.4
Medication: Co-codamol	5.0	5.8	9.8	-2.5	1.0	3.1
Supplements: Zinc	4.1	4.4	7.0	1.5	-2.7	-2.0
Qualifications: CSEs or equivalent	4.0	5.3	6.8	2.5	-1.7	-2.6
HDL Cholesterol	3.6	6.0	9.6	3.1	-1.7	-2.4
Basal cell carcinoma (self-reported)	3.4	4.1	11.8	-3.4	-0.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	3.3	4.2	10.5	3.2	-0.9	-1.1
Commuting to job workplace: Car/motor vehicle	3.3	3.8	6.1	-2.5	1.4	1.8
Medication: Simvastatin	3.0	4.3	10.8	-3.3	0.2	1.5
Alcohol drinker status: Previous	3.0	3.4	7.3	2.7	-1.1	-1.4
Depression (self-reported)	2.9	3.4	8.6	2.9	-0.4	-1.2
Age at last live birth	2.9	4.1	6.2	-1.1	2.2	2.5
Illnesses of father: Heart disease	2.7	3.7	5.2	-2.3	-1.9	1.6
Wears glasses or contact lenses	2.7	3.1	5.1	1.9	-2.3	-0.8
Medication: Atorvastatin	2.7	3.4	5.2	-2.3	-1.1	1.9
Age started oral contraceptive pill	2.6	3.3	4.7	-2.1	2.2	0.9
Age at first live birth	2.5	4.4	6.9	-1.2	2.6	2.2
Respiratory disease	2.3	5.1	5.4	2.2	-2.3	-2.3
Diabetes (mother)	2.2	2.8	5.7	1.6	-0.2	-2.4
Medication: Levothyroxine sodium	2.2	3.8	5.7	-2.0	1.3	-2.4
Heart attack	2.2	2.8	8.0	-2.8	-0.5	0.1
Exposure to tobacco smoke at home	2.2	2.4	6.5	0.9	2.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	4.0	-1.9	0.6	2.0
Risk taking	2.2	3.2	6.4	-1.0	2.5	1.5
Hand grip strength (left)	2.1	5.5	13.2	-3.6	0.3	1.8
Medication for pain relief, constipation, heartburn	2.1	3.6	7.0	-2.6	0.9	1.8
Medication: Omeprazole	2.1	2.5	5.9	2.4	-0.4	-1.2
Pulse rate	2.0	3.3	4.9	2.2	-2.2	-0.6
Medication: Aspirin	2.0	2.6	7.7	-2.8	0.4	-0.0
Financial difficulties in last 2 years	1.9	2.6	4.8	0.9	-2.2	-1.5
Overall health rating	1.9	4.2	9.6	1.0	-1.4	-3.1
Myopia	1.9	2.8	6.6	2.6	1.3	-0.1
Coronary Artery Disease (CAD)	1.8	2.1	3.5	-1.0	1.4	1.9
Medication: Cholesterol lowering	1.8	2.8	8.1	-2.9	-0.3	0.5
Family relationship satisfaction	1.8	2.3	6.6	-0.4	-2.6	0.2
Number of operations (self-reported)	1.8	2.6	4.5	1.4	-1.2	-2.1
Heart attack/myocardial infarction (self-reported)	1.8	2.4	6.6	-2.6	-0.7	0.0
Breast Cancer	1.7	4.0	8.1	2.8	-0.2	-2.0
Rheumatoid Arthritis	1.7	2.4	3.4	1.1	1.6	1.9
Hypothyroidism (self reported)	1.7	3.9	8.0	-2.8	1.0	-1.6
Mother’s age at death	1.7	2.2	3.0	1.7	-1.3	-1.4
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	7.4	-2.7	1.0	-1.1
Medication: Ibuprofen	1.6	1.9	5.4	2.3	-0.6	-0.3
Tinnitus: Yes, now most or all of the time	1.6	1.9	4.2	1.2	0.2	-2.0
Supplements: Calcium	1.6	1.7	4.3	2.1	0.5	-0.9
Ovarian Cancer	1.5	2.0	3.6	1.9	-0.3	-1.5
Type 2 Diabetes (T2D) (2012)	1.5	1.8	3.2	-1.4	1.8	0.2
Medication for hormone replacement therapy	1.5	1.6	4.0	2.0	0.5	-0.8
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	3.2	1.8	1.4	-0.0
Father’s age at death	1.5	2.0	5.5	2.3	-0.5	0.6
Illnesses of siblings: Diabetes	1.5	1.8	3.9	2.0	-0.5	-1.2
Medication: Blood pressure	1.5	2.8	4.9	-1.5	2.2	1.1
Alzheimer’s Disease (including proxy)	1.4	2.1	5.7	0.7	-2.4	-0.4
Mean Putamen Volume	1.4	1.6	2.8	-1.7	-0.9	1.0
Waist Hip Ratio (WHR)	1.4	6.1	9.4	2.9	-0.6	-3.1
Systolic Blood Pressure	1.4	7.2	14.2	2.0	-1.8	-3.8
Had menopause	1.4	1.8	2.3	-1.5	0.9	1.5
Lung cancer (father)	1.4	1.6	3.8	-2.0	0.9	0.6
Qualifications: nursing, teaching	1.4	2.2	6.4	-0.5	-2.5	0.1
Medication for cholesterol	1.4	2.1	3.3	1.8	-1.5	-0.8
Alzheimer’s Disease (in father)	1.3	1.4	2.2	0.4	-1.5	-1.3
Prostate Cancer	1.3	1.8	4.3	0.9	0.6	-2.1
Age at First Birth	1.3	1.9	3.0	-1.6	-0.6	1.7
Hand grip strength (right)	1.3	3.5	7.9	-2.8	-0.8	1.4
High blood pressure (mother)	1.3	1.8	4.4	0.4	0.9	-2.1
Number of live births	1.3	1.8	3.3	1.3	-1.8	-0.6
Length of working week for main job	1.3	1.5	4.0	0.2	0.6	-2.0
Angina (self-reported)	1.3	1.7	4.7	-2.2	-0.6	0.1
Smoking status: Previous	1.3	1.9	4.3	-2.1	0.7	0.9
Average weekly red wine intake	1.3	2.0	3.3	-0.5	-1.8	-1.5
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.3	0.7	-0.9	-1.8
Financial situation satisfaction	1.3	1.6	2.8	1.7	-1.2	-0.8
Alzheimer’s Disease (in mother)	1.2	1.4	2.1	1.4	-1.5	0.1
Angina	1.2	1.6	4.7	-2.2	-0.2	0.2
Headache pain in last month	1.2	2.1	5.5	2.3	0.3	-0.8
Exposure to tobacco smoke outside home	1.2	1.6	2.5	1.1	1.0	-1.6
Comparative body size at age 10	1.2	3.2	5.3	-2.0	2.3	-0.2
Medication: Aspirin	1.2	1.6	4.4	-2.1	0.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.0	1.2	1.4	-0.7
Ever taken oral contraceptive pill	1.2	1.3	3.2	1.8	-0.5	-0.8
Lupus	1.1	1.7	4.6	-0.7	2.1	-0.5
Past tobacco smoking	1.1	2.0	5.1	2.2	-0.8	-0.5
Supplements: Vitamin C	1.1	1.3	2.5	1.0	0.6	1.6
Friendships satisfaction	1.1	1.3	3.5	0.6	-1.9	-0.3
Eye problems/disorders: Cataract	1.1	1.3	2.4	-1.5	0.9	0.8
Vitamin and mineral supplements	1.0	1.3	2.1	-1.4	0.8	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.7	-1.9	-0.1	0.7
Had other major operations	1.0	1.2	1.6	0.9	-1.3	-1.1
Diabetes (self-reported)	1.0	1.5	3.3	-1.8	-1.1	-0.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.3	-1.8	0.8	-0.1
High blood pressure (siblings)	1.0	1.4	3.9	-2.0	0.6	0.2
Leg fat percentage (right)	1.0	3.5	5.7	-2.1	2.4	0.7
Had major operations	1.0	1.2	2.8	-0.0	-1.0	-1.7
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.8	-0.7	1.2	1.3
Ever had bowel cancer screening	1.0	1.2	1.4	1.2	-0.8	1.2
Asthma (self-reported)	1.0	2.1	3.4	0.9	-1.8	-1.5
Medication: Paracetamol	1.0	1.6	4.4	2.1	0.4	0.4
Ever smoked	1.0	1.7	3.4	-1.9	1.3	0.0
Leg fat percentage (left)	1.0	3.5	5.7	-2.1	2.4	0.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.0	-0.6	0.3	1.7
Schizophrenia vs Biploar Disorder	0.9	1.2	2.7	-0.7	-1.6	0.6
Triglycerides	0.9	1.4	2.3	-1.5	1.4	-0.0
BMI	0.9	5.0	7.9	-2.7	2.8	-0.2
Severe depression (siblings)	0.9	1.0	1.5	0.2	1.2	1.2
Medication: Lansoprazole	0.9	1.0	2.5	-1.6	0.2	-0.7
Illnesses of mother	0.9	1.1	2.6	-0.4	-0.7	1.6
Blood clot in the leg (DVT)	0.9	1.2	2.9	0.2	-0.8	-1.7
Medication: Amlodipine	0.9	1.2	2.3	0.2	1.1	-1.5
Birth weight	0.9	1.9	3.8	-1.1	0.9	2.0
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.6	-1.1	1.3	0.4
Chest pain or discomfort	0.9	1.2	2.7	-1.6	0.9	-0.4
Medication: Bendroflumethiazide	0.9	1.4	3.4	-0.5	1.8	0.8
Schizophrenia (2018)	0.8	1.6	2.6	0.5	-1.4	1.6
Body Mass Index (BMI) (2010)	0.8	1.1	2.5	-0.7	0.5	-1.6
Allergy or Eczema	0.8	2.1	5.6	2.4	-0.7	-0.3
Chronotype (morning person)	0.8	1.8	2.3	1.5	-0.9	-1.4
Maternal smoking around birth	0.8	1.1	1.5	0.7	1.2	-1.2
Fed-up feelings	0.8	1.5	2.7	0.3	1.6	1.3
Multivitamins +/- minerals	0.8	1.1	1.7	0.2	-1.2	-1.3
Stomach or abdominal pain in last month	0.8	1.0	3.1	0.2	-1.7	-0.2
Body mass index (BMI)	0.8	3.5	6.3	-2.0	2.5	-0.5
Alcohol intake versus 10 years previously	0.8	1.1	2.3	1.0	0.2	-1.5
Qualifications: A levels/AS levels or equivalent	0.8	1.8	2.9	-1.6	-0.1	1.7
Asthma	0.8	1.5	2.9	0.5	-1.7	-1.2
Breastfed as a baby	0.8	1.0	1.7	-1.1	-1.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.4	0.9	1.5	0.6
Pulse wave reflection index	0.8	1.0	2.6	-1.6	-0.2	0.6
Loud music exposure frequency	0.8	0.9	1.7	-0.8	-1.3	0.6
Medication: Paracetamol	0.8	1.3	3.9	2.0	0.2	-0.0
Shortness of breath walking on level ground	0.8	1.0	1.8	-0.5	1.3	1.0
Eye problems/disorders: None of the above	0.8	0.9	1.8	1.0	0.2	-1.3
Suffer from ‘nerves’	0.8	1.3	2.2	-0.5	1.2	1.5
Commuting to job workplace: Walk	0.8	0.9	1.5	1.2	-0.6	-0.9
Breast cancer (self-reported)	0.8	1.0	1.8	-1.3	1.0	0.4
Average weekly champagne plus white wine intake	0.8	1.1	1.3	1.1	0.9	1.0
Miserableness	0.8	1.4	3.4	1.8	-0.8	-0.2
Irritability	0.8	1.3	3.6	0.3	1.9	-0.5
Depression (Nagel 2018)	0.7	1.1	2.2	-1.5	-1.0	0.3
Bipolar Disorder (2011)	0.7	0.7	1.6	-0.8	0.1	1.3
Fasting Glucose	0.7	0.8	1.6	0.9	-0.1	-1.2
Schizophrenia (2014)	0.7	1.5	3.3	-0.4	-1.0	1.8
Smoking Status	0.7	1.8	4.6	-2.2	0.7	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.7	1.2	-0.8	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	3.0	1.7	-1.3	-0.7
Falls in the last year	0.7	0.9	2.0	-0.9	-1.4	0.3
Wheeze or whistling in the chest in last year	0.7	1.2	2.8	0.4	-1.7	-0.9
Number of children fathered	0.7	0.8	2.1	-1.4	-0.3	0.5
Medication: Blood pressure	0.7	1.2	3.1	0.5	0.3	-1.8
Mean time to correctly identify matches	0.7	1.2	2.2	-1.2	-0.4	1.5
Leg fat mass (right)	0.7	2.8	4.9	-2.2	1.8	0.3
Alcohol intake frequency.	0.7	1.6	2.8	0.9	-1.7	-1.1
Diabetes diagnosed by doctor	0.7	1.1	3.1	-1.8	-0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.9	0.5	-0.7	-1.4
Leg fat mass (left)	0.7	2.8	4.8	-2.2	1.9	0.3
Systolic blood pressure, automated reading	0.6	1.7	2.8	-0.6	-1.7	-1.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.7	-1.3	-0.2	0.1
Medication: Ramipril	0.6	0.8	2.0	-0.0	1.4	-0.5
Prospective memory result	0.6	0.7	1.9	-0.6	-0.2	1.4
Tense / ‘highly strung’	0.6	0.9	2.2	-0.2	1.5	0.7
Birth weight of first child	0.6	1.0	2.5	1.6	-0.6	0.6
Body fat percentage	0.6	2.4	4.8	-1.6	2.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.9	1.4	0.5	0.4
Neck or shoulder pain in last month	0.6	0.8	1.9	1.4	-0.5	-0.6
Migraine (self-reported)	0.6	0.7	1.2	1.0	0.1	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	-0.1	1.1	0.9
Arm fat percentage (left)	0.6	2.5	4.7	-1.7	2.2	-0.1
Mood swings	0.6	1.2	1.3	1.1	1.0	1.1
Loneliness, isolation	0.6	0.8	1.6	0.8	1.3	0.3
Medication: Gliclazide	0.6	0.6	1.2	-0.8	1.1	0.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.1	0.8	0.6	-1.0
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.0	-0.8	-0.8	1.0
Fractured/broken bones in last 5 years	0.6	0.8	1.5	-0.9	-1.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.9	1.4	-0.3	-0.4
Cardiovascular Disease	0.5	1.6	4.0	-2.0	0.9	-0.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.0	-0.0	-1.4	0.0
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.1	-0.1	0.8	1.0
Serious illness, injury or assault to yourself	0.5	0.6	1.7	-0.4	-1.3	0.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.8	0.8	-0.7	0.9
Medication: Atenolol	0.5	0.6	1.1	1.1	-0.3	-0.7
Arm fat percentage (right)	0.5	2.1	3.5	-1.7	1.9	-0.0
Happiness	0.5	0.6	1.2	0.6	-1.1	0.5
Ever highly irritable/argumentative for 2 days	0.5	0.5	1.3	-0.0	-0.6	1.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	1.8	-0.9	-0.1	1.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.0	1.4	-0.2	0.7
Worry too long after embarrassment	0.5	0.8	2.3	-0.2	-1.5	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.3	1.1	0.7	0.2
Emphysema/chronic bronchitis	0.5	0.5	1.0	0.7	-1.0	0.2
Number of full sisters	0.5	0.6	1.7	1.3	-0.1	-0.0
Long-standing illness, disability or infirmity	0.5	0.8	2.2	-0.3	-1.5	0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.3	1.5	-0.4	-0.4
Osteoarthritis (self-reported)	0.5	0.6	1.0	-1.0	0.7	0.6
Illnesses of father: High blood pressure	0.5	0.6	0.8	0.6	-0.8	-0.9
Diastolic blood pressure, automated reading	0.5	1.5	2.5	0.4	-1.3	-1.6
Ever depressed for a whole week	0.5	0.6	0.8	-0.8	-0.9	0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	2.6	0.4	-0.5	1.6
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.3	-1.8	-0.5	0.8
Major Depression (MDD)	0.4	0.5	1.3	-0.4	1.1	-0.2
Blood Platelet Count	0.4	4.4	9.8	1.8	0.3	3.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.2	-1.0	-1.1	-0.4
Lung FVC	0.4	1.9	2.9	-1.7	0.4	1.6
Relative age of first facial hair	0.4	0.9	2.6	-1.6	0.1	0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.0	-0.3	1.0	-0.7
Diabetes (father)	0.4	0.5	1.3	0.3	-1.1	-0.0
Trunk fat percentage	0.4	1.7	3.7	-1.1	1.9	0.4
Trunk fat mass	0.4	1.5	2.7	-1.3	1.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.2	0.1	-0.7	1.1
Hearing difficulty/problems with background noise	0.4	0.7	0.9	0.9	-0.8	-0.7
Allergy	0.4	1.0	1.5	-0.9	1.2	0.7
Pain all over the body in last month	0.4	0.5	1.0	-0.6	1.0	0.1
Fluid intelligence score	0.4	0.8	1.6	-0.9	-1.3	-0.2
Impedance of arm (right)	0.4	1.8	3.1	1.8	-1.5	-0.2
Worrier / anxious feelings	0.4	0.8	1.4	1.2	-1.0	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.8	0.0	1.4	0.4
Arm fat mass (right)	0.4	1.5	2.9	-1.7	1.2	-0.1
Peak expiratory flow (PEF)	0.4	1.0	2.3	-0.8	0.5	1.5
Number of full brothers	0.4	0.5	0.7	0.8	-0.5	-0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	-0.0	-0.6	1.1
Heart disease (mother)	0.4	0.5	0.9	-0.3	-0.6	-1.0
Whole body fat mass	0.4	1.9	3.0	-1.7	1.6	-0.1
Knee pain experienced in last month	0.4	0.7	2.0	-0.1	1.4	0.1
Osteoporosis (self-reported)	0.4	0.5	1.4	0.4	1.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.8	-1.3	0.9	0.3
Arm fat mass (left)	0.4	1.6	3.0	-1.7	1.3	-0.2
Heart disease (siblings)	0.4	0.5	0.9	-0.8	1.0	0.2
Crohns Disease (2017)	0.3	0.6	1.1	0.3	-1.1	-0.7
Irritable Bowel Disease (IBD)	0.3	0.7	1.2	0.4	-1.1	-0.8
Reaction Time	0.3	0.5	0.6	-0.7	-0.8	0.6
Neuroticism (2016)	0.3	0.4	0.9	1.0	0.4	-0.4
Lung FEV1/FVC ratio	0.3	1.7	1.8	-1.4	1.3	1.3
Average weekly spirits intake	0.3	0.4	0.5	-0.6	0.5	0.7
Impedance of leg (right)	0.3	1.3	1.6	1.3	-1.1	1.0
Townsend deprivation index at recruitment	0.3	0.5	1.2	-1.1	-0.2	-0.4
Average weekly fortified wine intake	0.3	0.4	0.9	-0.3	-0.4	0.9
Age when periods started (menarche)	0.3	0.8	2.3	0.1	-1.5	0.0
Waist circumference	0.3	1.0	1.9	-0.8	1.4	-0.6
Hair/balding pattern: Pattern 2	0.3	0.3	0.5	-0.7	-0.4	0.5
Weight	0.3	1.3	2.7	-1.6	1.1	-0.3
Hip circumference	0.3	1.5	2.3	-1.5	1.4	0.3
Impedance of arm (left)	0.3	1.4	2.7	1.6	-1.2	-0.0
Hair/balding pattern: Pattern 4	0.3	0.6	1.4	-0.4	1.2	-0.5
Glaucoma (self-reported)	0.3	0.3	0.8	0.9	0.1	0.3
Comparative height size at age 10	0.3	1.9	3.6	1.4	-1.9	0.4
Leg pain on walking	0.3	0.3	0.6	0.2	0.6	-0.7
Back pain experienced in last month	0.3	0.5	1.0	1.0	0.7	0.2
Commuting to job workplace: Public transport	0.3	0.3	0.8	0.5	-0.0	-0.9
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	0.6	-0.8	0.2
Impedance of whole body	0.3	1.6	3.2	1.8	-1.1	0.5
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	1.1	0.0	0.3
Worry (Nagel 2018)	0.2	0.5	1.0	-0.1	-0.7	1.0
Ulcerative Colitis (UC)	0.2	0.3	0.6	0.4	-0.5	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.8	0.1	-0.8	-0.9
Heel T-Score	0.2	1.9	3.6	-1.2	1.9	0.8
Height	0.2	3.0	7.7	1.2	-2.8	0.2
Hair Pigment	0.2	5.5	8.1	-0.9	2.8	2.8
Number of treatments/medications taken	0.2	0.3	0.5	0.2	0.6	0.7
Hearing difficulty/problems: Yes	0.2	0.2	0.4	0.5	0.6	0.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	0.7	-0.1	0.2
Medication: Metformin	0.2	0.2	0.4	-0.7	-0.4	-0.1
Leg fat-free mass (left)	0.2	0.9	1.2	-1.1	0.7	-0.9
Taking other prescription medications	0.2	0.3	0.7	-0.8	0.3	-0.1
High blood pressure	0.2	0.7	1.7	0.5	0.3	-1.3
Impedance of leg (left)	0.2	1.1	1.3	1.1	-1.0	1.0
Leg predicted mass (left)	0.2	0.9	1.3	-1.1	0.6	-1.0
Number of incorrect matches in round	0.2	0.4	0.7	0.5	-0.8	0.5
Alcohol usually taken with meals	0.2	0.3	0.7	-0.4	0.1	0.8
Forced vital capacity (FVC)	0.2	0.6	1.4	-1.2	-0.6	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	0.1	-0.8	0.3
Time employed in main current job	0.2	0.2	0.6	-0.3	0.0	0.8
Noisy workplace	0.2	0.2	0.5	0.4	0.7	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.4	0.1	-0.6	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.0	-0.9	-1.0	0.6
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.5	-0.7	0.1
Standing height	0.2	2.4	7.0	0.4	-2.7	0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	0.8	0.0	0.0
Forced vital capacity (FVC), Best measure	0.2	0.9	1.5	-1.2	-0.8	0.7
Pulse wave peak to peak time	0.2	0.3	0.5	0.5	0.7	-0.2
Health satisfaction	0.2	0.3	0.8	-0.2	-0.3	-0.9
Qualifications: College or University degree	0.2	0.8	1.6	1.3	0.6	-0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.7	-0.0	0.2
Pulse rate, automated reading	0.2	0.5	1.2	1.1	-0.4	-0.5
Hypertension (Self-reported)	0.2	0.5	1.0	0.4	0.6	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	0.5	-0.2	-0.6
Leg fat-free mass (right)	0.2	0.9	1.6	-1.3	0.5	-1.0
Leg predicted mass (right)	0.2	0.9	1.7	-1.3	0.5	-0.9
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	0.5	0.9	0.2
Guilty feelings	0.2	0.3	0.9	0.2	-1.0	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	0.2	-1.0	-0.1
Medication: Lisinopril	0.2	0.3	0.5	0.7	-0.6	0.1
Unable to work because of sickness or disability	0.2	0.3	0.6	-0.8	0.1	0.5
Pain experienced in last month	0.2	0.3	0.8	-0.9	-0.2	0.1
Pack years of smoking	0.2	0.3	0.6	-0.2	-0.8	-0.5
Bipolar Disorder (2018)	0.1	0.2	0.4	-0.1	0.6	0.5
Neuroticism (Nagel 2018)	0.1	0.3	0.4	0.6	-0.6	0.4
HbA1C	0.1	0.1	0.4	0.6	-0.1	-0.1
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.5	-0.4	0.2
Ulcerative Colitis	0.1	0.2	0.3	-0.5	0.0	-0.5
Blood Eosinophil Count	0.1	1.1	2.7	-1.6	0.4	0.6
Blood Red Count	0.1	0.9	1.6	1.3	-0.6	-0.9
Blood White Count	0.1	1.0	2.6	0.6	1.6	0.1
Neuroticism	0.1	0.2	0.5	-0.3	-0.3	0.7
Tanning	0.1	0.8	1.2	1.1	0.6	1.0
Sensitivity / hurt feelings	0.1	0.2	0.2	-0.5	0.4	0.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.3	-0.5	-0.0
Pack years adult smoking proportion	0.1	0.2	0.4	-0.2	-0.7	-0.4
Current tobacco smoking	0.1	0.1	0.2	0.3	-0.1	-0.5
Relative age voice broke	0.1	0.1	0.1	-0.3	-0.1	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.8	0.9	-0.1	-0.3
Supplements: Glucosamine	0.1	0.2	0.4	0.6	-0.3	-0.0
Nervous feelings	0.1	0.1	0.3	0.2	-0.6	0.1
Qualifications: None of the above	0.1	0.1	0.3	-0.3	-0.1	-0.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.4	0.2	-0.0	0.6
Illnesses of siblings	0.1	0.1	0.3	0.0	-0.5	-0.1
Neuroticism score	0.1	0.2	0.3	0.6	0.4	0.2
Trunk fat-free mass	0.1	0.6	1.1	-1.0	-0.7	-0.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	0.2	0.3	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	-0.8	-0.5	0.2
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	-0.6	-0.4	-0.4
Trunk predicted mass	0.1	0.6	1.0	-1.0	-0.7	-0.6
Gout (self-reported)	0.1	0.1	0.2	0.2	0.3	0.5
Arm fat-free mass (right)	0.1	0.3	1.0	-1.0	-0.0	-0.2
Arm predicted mass (right)	0.1	0.4	1.1	-1.0	0.4	-0.3
Whole body fat-free mass	0.1	0.6	1.1	-1.0	-0.1	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.3	0.4	-0.4
Mineral and other dietary supplements	0.1	0.1	0.3	-0.1	-0.5	0.0
Smoking status: Current	0.1	0.1	0.3	0.3	-0.1	-0.5
Whole body water mass	0.1	0.6	1.0	-1.0	-0.1	-0.8
Hearing aid user	0.1	0.1	0.1	-0.3	-0.4	-0.2
Alcohol drinker status: Never	0.1	0.1	0.2	-0.0	-0.5	0.0
Basal metabolic rate	0.1	0.7	1.6	-1.3	0.2	-0.7
Arm fat-free mass (left)	0.1	0.5	1.0	-1.0	-0.1	-0.7
Average weekly beer plus cider intake	0.1	0.1	0.4	0.0	0.6	0.1
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.3	0.4	0.0
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.7	0.6	-0.2	0.8
Arm predicted mass (left)	0.1	0.6	1.7	-1.3	-0.2	-0.3
Crohns Disease (2012)	0.0	0.1	0.1	0.3	-0.3	-0.1
Sitting height	0.0	0.2	0.5	0.3	-0.7	-0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	0.2	-0.1	0.1
Mouth/teeth dental problems	0.0	0.1	0.2	0.4	-0.0	-0.1
Medication: Allopurinol	0.0	0.0	0.1	0.1	-0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.1	-0.0	0.3	-0.1

Hub : Genes

N4BP2L1

Models

Trait associations