Hub : Genes

SP4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.2000 0.0690 3.1e-03 -0.004 NA -0.005 NA 0.000 6.5e-01 NA 8.3e-01 NA 3.2e-01
2 GTEx Artery Tibial 0.1336 0.0415 1.1e-03 0.011 NA 0.014 NA 0.019 4.1e-02 NA 2.6e-02 NA 1.1e-02
3 GTEx Breast Mammary Tissue 0.1430 0.0550 8.9e-03 0.029 NA 0.003 NA 0.021 1.2e-02 NA 2.2e-01 NA 3.0e-02
4 GTEx Breast Mammary Tissue (Male) 0.1176 0.0986 1.8e-01 0.017 NA 0.007 NA 0.028 1.3e-01 NA 2.2e-01 NA 7.6e-02
5 GTEx Breast Mammary Tissue (Female) 0.1819 0.1153 9.1e-02 0.007 NA 0.018 NA 0.027 1.9e-01 NA 9.3e-02 NA 5.2e-02
6 GTEx Esophagus Muscularis 0.1490 0.0510 3.5e-03 0.012 NA 0.008 NA 0.005 6.0e-02 NA 9.5e-02 NA 1.6e-01
7 NTR Blood 0.0241 0.0095 6.4e-03 0.017 0.007 0.018 0.011 0.019 1.9e-06 2.2e-03 1.3e-06 1.2e-04 8.1e-07
8 YFS Blood 0.0908 0.0193 1.5e-11 0.010 0.046 0.048 0.047 0.034 2.5e-04 1.0e-14 2.7e-15 4.8e-15 2.2e-11
9 TCGA Kidney Renal Clear Cell Carcinoma 0.0475 0.0262 5.3e-03 0.005 0.010 0.006 NA 0.001 8.3e-02 2.5e-02 6.2e-02 NA 2.7e-01
10 TCGA Brain Lower Grade Glioma 0.0559 0.0310 4.3e-03 0.001 0.017 0.019 NA 0.012 2.6e-01 3.9e-03 2.4e-03 NA 1.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 2.6 4.1 8.9 1.7 3.0 0.7 0.0 -0.7 2.4 -2.8 3.0 1.9 -1.3
Bipolar Disorder or Schizophrenia 4.2 10.3 26.6 2.6 5.2 1.3 0.0 -0.6 3.5 -4.9 4.1 3.5 -1.4
Depressed Affect (Nagel 2018) 2.9 6.2 15.6 3.5 4.0 0.2 0.0 1.4 3.0 -2.7 0.2 3.9 0.7
Depression (Nagel 2018) 3.2 4.8 12.2 2.2 3.5 -0.1 0.0 1.7 2.6 -2.4 1.8 3.5 -0.5
Intelligence (Savage-Jansen 2018) 1.6 5.0 16.6 -1.9 -3.5 -1.1 0.0 -1.5 -1.9 3.1 1.2 -4.1 0.2
Neuroticism (Nagel 2018) 2.8 6.5 18.7 3.6 4.3 0.5 0.0 -0.2 3.7 -3.0 0.1 3.1 0.3
Schizophrenia (2018) 3.0 6.3 17.9 2.0 4.2 1.1 0.0 -0.2 2.6 -4.1 2.7 2.9 -0.7
Schizophrenia vs Biploar Disorder 0.3 0.3 1.1 -0.2 -1.1 0.2 0.0 0.7 0.1 1.0 -0.8 0.1 0.1
Worry (Nagel 2018) 1.3 2.8 8.3 2.6 2.9 -0.2 0.0 -0.5 2.6 -1.8 -0.2 1.4 0.2
Alzheimer’s Disease (in mother) 0.3 0.4 1.6 -0.6 -0.5 -0.3 0.0 0.6 -0.2 1.2 0.5 0.8 -0.6
Alzheimer’s Disease (in father) 1.4 1.6 5.4 0.6 2.3 -1.1 0.0 -1.0 1.4 -1.2 1.2 1.7 -0.3
Alzheimer’s Disease (including proxy) 0.4 0.6 3.3 -0.2 0.9 -0.3 0.0 0.1 0.2 0.4 1.0 1.8 -0.7
Crohns Disease (2017) 0.4 0.8 2.4 -0.6 0.2 1.5 0.0 0.3 -1.2 0.9 -1.0 -1.2 0.6
Irritable Bowel Disease (IBD) 0.2 0.6 1.7 -0.8 0.6 0.2 0.0 1.3 -1.2 1.0 -0.6 0.1 0.3
Ulcerative Colitis (UC) 0.2 0.5 1.8 -0.2 0.7 -0.7 0.0 1.4 -0.6 0.4 0.2 1.1 0.1
Major Depression (MDD) 2.7 3.3 9.7 3.1 2.6 0.0 0.0 -1.3 2.5 -2.5 0.6 1.6 0.3
Reaction Time 0.3 0.7 1.5 -1.0 -1.2 0.9 0.0 -0.3 -1.1 1.0 0.6 -0.7 0.4
Verbal and Numeric Reasoning (VNR) 1.6 3.9 18.1 -1.4 -1.9 -0.6 0.0 -3.0 -0.8 2.2 -0.2 -4.3 0.4
Breast Cancer 1.0 2.3 5.3 -1.1 -2.0 -2.2 0.0 1.6 -2.3 0.7 -0.2 -1.5 1.6
Ovarian Cancer 0.9 1.2 3.1 -1.8 -1.6 -0.8 0.0 1.2 -0.7 1.4 -0.4 -0.7 1.0
Prostate Cancer 0.6 0.9 2.0 1.3 0.6 1.2 0.0 -1.4 0.1 0.1 -1.1 -0.1 -1.4
Age at First Birth 2.6 3.8 8.2 -2.3 -2.7 -0.6 0.0 -0.6 -0.9 2.9 2.3 -2.2 -2.2
Bipolar Disorder (2011) 2.9 2.8 7.2 1.8 2.2 1.5 0.0 -0.9 0.4 -2.5 2.7 1.5 -1.3
Body Mass Index (BMI) (2010) 0.6 0.8 2.4 0.6 1.6 -0.7 0.0 -1.3 0.7 -1.4 0.6 -0.3 -0.2
Coronary Artery Disease (CAD) 0.7 0.8 4.7 2.2 -0.3 0.0 0.0 1.3 0.1 -1.0 -0.4 0.9 0.3
Crohns Disease (2012) 0.4 0.7 2.4 0.2 -0.2 1.5 0.0 -0.4 -1.4 0.9 -0.2 -0.7 0.9
Mean Putamen Volume 0.5 0.6 1.4 0.3 1.1 0.5 0.0 1.2 -0.0 -1.2 0.9 0.9 -0.4
Fasting Glucose 1.6 1.9 5.9 -2.4 -1.3 -0.6 0.0 2.3 -1.8 0.8 0.3 -1.0 -0.9
HbA1C 0.8 0.9 3.2 -0.3 1.6 -0.2 0.0 1.2 -0.5 -1.8 1.2 0.2 -0.5
HDL Cholesterol 0.3 0.4 1.1 0.2 -0.7 0.7 0.0 -0.6 -0.3 1.0 0.1 -0.7 -1.1
LDL Cholesterol 3.6 5.7 15.8 -1.1 -4.0 -1.1 0.0 0.9 -3.6 2.8 -1.7 -2.7 2.5
Lupus 1.2 1.8 5.5 -1.8 -1.3 0.0 0.0 1.0 -2.3 1.4 -1.7 -1.3 -0.6
Neuroticism (2016) 1.5 2.2 6.4 1.6 1.1 -1.8 0.0 0.4 2.5 -1.9 -0.7 1.8 0.7
Primary Biliary Cirrhosis 0.7 1.0 3.1 -0.8 1.1 -0.4 0.0 0.9 -0.1 -1.1 0.7 1.8 -1.6
Rheumatoid Arthritis 0.5 0.7 2.2 -0.4 -1.0 0.1 0.0 0.4 -1.2 1.1 0.0 -0.7 1.5
Schizophrenia (2014) 2.4 5.3 14.1 2.2 3.5 0.9 0.0 -1.9 2.6 -3.8 2.3 2.2 -1.2
Triglycerides 0.7 1.1 3.8 -0.2 -1.3 -0.2 0.0 -0.2 -0.9 1.5 -1.9 -1.4 0.5
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.6 0.5 0.9 -0.1 0.0 0.0 0.9 -1.2 1.0 1.1 -0.0
Ulcerative Colitis 0.4 0.6 2.4 0.9 0.6 -0.6 0.0 -0.1 -1.5 0.1 -0.6 1.3 0.5
Blood Eosinophil Count 0.1 1.1 5.4 -2.3 -0.4 0.0 0.0 1.9 -0.9 0.2 1.0 0.6 -0.2
Blood Platelet Count 0.4 4.3 12.7 -0.8 -2.5 -0.6 0.0 0.3 -2.0 3.0 -3.6 -2.6 1.8
Blood Red Count 0.8 7.3 15.1 -1.8 -3.9 -1.3 0.0 2.0 -3.8 3.3 -3.3 -2.1 2.8
Blood White Count 0.2 1.5 4.3 1.1 0.1 -0.1 0.0 1.1 1.5 1.4 -2.1 0.6 1.8
Heel T-Score 0.1 0.9 3.4 0.1 -0.7 -0.1 0.0 0.2 -0.9 1.8 0.8 -1.8 0.9
BMI 1.1 6.4 14.9 3.0 3.5 -0.2 0.0 1.6 2.9 -3.2 -0.6 3.9 2.5
Height 0.0 0.8 3.1 -0.2 -0.5 0.2 0.0 -1.8 -0.5 1.6 0.4 0.1 -1.4
Waist Hip Ratio (WHR) 0.2 1.1 3.2 0.5 1.8 -1.1 0.0 1.2 -0.1 -1.2 -0.4 1.4 1.2
Systolic Blood Pressure 0.2 1.0 4.2 0.7 0.8 -1.0 0.0 0.4 -0.0 -0.1 -0.8 1.6 -2.0
Smoking Status 0.8 1.9 6.3 2.0 1.9 -0.1 0.0 1.7 0.1 -1.5 0.0 2.5 0.0
Allergy or Eczema 0.5 1.2 3.0 0.2 0.6 1.5 0.0 -1.1 0.9 -1.5 1.5 0.3 -1.7
Cardiovascular Disease 0.5 1.7 5.9 1.8 0.3 0.1 0.0 -0.2 0.7 -1.0 -2.4 1.1 2.3
Hypothyroidism (self reported) 0.1 0.3 1.0 0.4 0.2 -0.8 0.0 -0.4 -0.5 0.0 -1.0 0.3 0.5
Respiratory disease 0.3 0.7 2.7 1.0 0.4 -0.2 0.0 -0.6 1.2 -1.6 0.1 1.1 0.3
Type 2 Diabetes (T2D) (2018) 0.6 1.1 3.9 0.9 1.2 -1.2 0.0 0.8 1.1 -0.3 -2.0 1.0 -0.4
Lung FEV1/FVC ratio 0.6 2.8 7.5 -2.5 -2.0 0.5 0.0 0.7 -2.7 1.8 -0.1 -2.5 -0.2
Lung FVC 0.8 3.9 13.3 -3.6 -1.8 0.5 0.0 0.9 -1.4 1.1 1.0 -2.1 -3.5
Neuroticism 3.3 8.0 19.8 4.1 4.5 -0.3 0.0 -1.0 3.5 -3.8 0.4 3.4 2.0
Chronotype (morning person) 1.4 3.2 7.9 2.8 1.9 0.5 0.0 -0.6 2.7 -2.2 0.2 2.8 0.6
Hair Pigment 0.0 0.3 1.1 0.7 0.2 0.8 0.0 -1.0 -0.1 0.1 0.6 -0.2 -0.3
Tanning 0.1 1.6 4.2 0.3 0.2 -1.8 0.0 2.1 -0.7 -1.3 -1.4 1.8 0.9
Hand grip strength (left) 1.5 4.0 12.2 -3.2 -3.5 -1.2 0.0 0.8 -1.4 1.4 1.1 -2.1 -2.3
Number of treatments/medications taken 0.8 1.5 5.8 0.9 1.4 1.7 0.0 0.8 0.1 -1.7 0.4 2.4 -0.5
Average weekly spirits intake 0.3 0.4 1.3 -0.4 0.7 0.2 0.0 1.2 -0.4 -0.9 0.2 0.5 -0.5
Sensitivity / hurt feelings 2.7 4.7 12.4 3.0 3.3 1.5 0.0 -1.7 3.5 -2.0 0.1 2.4 -0.3
Frequency of depressed mood in last 2 weeks 3.4 4.7 13.0 3.3 2.6 0.6 0.0 1.2 2.7 -2.5 0.7 3.6 0.7
Hearing difficulty/problems: Yes 0.9 1.4 4.2 0.3 1.1 2.0 0.0 0.1 1.3 -1.4 -0.2 2.0 -0.9
Relative age of first facial hair 0.5 0.9 2.7 -0.3 -0.7 0.5 0.0 1.6 1.5 0.1 -0.1 1.5 1.1
Other serious medical condition/disability diagnosed by doctor 1.9 2.4 5.2 1.9 2.3 1.9 0.0 -0.2 1.7 -2.3 0.6 1.8 0.4
Ever used hormone-replacement therapy (HRT) 2.4 3.0 10.4 1.6 3.2 1.4 0.0 -0.3 1.8 -2.6 1.6 1.7 -0.5
Ever had hysterectomy (womb removed) 0.2 0.2 1.3 0.2 -1.2 -0.2 0.0 0.2 -0.4 -0.1 0.1 0.1 -0.4
Systolic blood pressure, automated reading 0.5 1.5 3.8 0.3 1.4 -1.0 0.0 1.0 1.0 -1.2 1.2 1.9 -1.8
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 3.5 -0.3 0.6 -1.1 0.0 -0.1 0.7 -1.9 -1.5 0.5 -0.5
Angina 0.8 1.0 4.0 0.9 -1.0 -0.9 0.0 -0.3 0.4 1.0 -1.5 -0.1 2.0
Medication for hormone replacement therapy 1.7 1.9 5.9 -0.2 1.5 -2.4 0.0 -1.1 0.3 -2.1 0.5 0.7 -2.1
Vitamin and mineral supplements 0.2 0.3 1.3 0.4 -0.7 0.2 0.0 0.1 -0.2 0.5 0.7 1.1 0.1
Supplements: Zinc 0.6 0.7 2.3 0.2 1.4 -0.7 0.0 0.6 1.5 -0.7 -0.6 0.8 0.4
Medication: Co-codamol 0.4 0.5 1.2 -0.1 0.8 -1.1 0.0 0.2 -1.1 0.7 0.5 0.4 -1.0
Medication: Metformin 0.8 1.2 8.1 0.5 -0.4 -1.1 0.0 0.5 -0.0 0.7 -2.9 -0.5 1.0
Diabetes (father) 1.0 1.2 3.4 0.7 0.9 0.7 0.0 -0.4 1.4 -0.8 1.8 1.9 -0.7
Diabetes (mother) 0.2 0.3 1.2 1.1 0.1 -0.1 0.0 1.0 -0.1 -0.3 -0.2 -0.4 0.5
Severe depression (siblings) 2.7 3.0 8.2 1.6 2.6 -0.1 0.0 -1.6 2.5 -2.9 1.5 1.0 -0.3
Pack years adult smoking proportion 0.2 0.3 1.1 0.5 -0.2 -0.5 0.0 -0.5 -0.6 0.3 -1.1 0.5 -0.0
Impedance of leg (right) 0.9 4.2 13.2 -1.6 -2.9 -1.1 0.0 1.9 -2.6 3.6 -1.4 -1.9 1.1
Leg fat-free mass (left) 0.8 4.4 12.5 2.5 3.0 0.4 0.0 -0.7 2.5 -3.5 1.4 2.5 -0.7
Trunk fat percentage 1.0 3.8 14.3 1.7 3.8 0.8 0.0 1.5 2.3 -2.6 0.4 2.1 1.1
Hand grip strength (right) 1.1 3.0 10.1 -2.5 -3.2 -1.4 0.0 0.1 -1.2 1.8 0.7 -1.9 -1.8
Townsend deprivation index at recruitment 0.2 0.2 0.5 0.4 0.3 0.5 0.0 -0.6 -0.7 -0.2 -0.3 0.7 0.5
Current tobacco smoking 0.3 0.6 3.1 -1.0 0.0 -1.8 0.0 0.9 -0.2 -0.5 -0.2 -0.2 -0.6
Average weekly fortified wine intake 0.9 1.0 4.9 -0.4 -0.3 -0.1 0.0 -0.0 -1.3 2.2 -0.6 -1.5 1.0
Maternal smoking around birth 1.7 2.4 7.0 1.6 2.6 -0.3 0.0 1.8 0.5 -1.9 -0.8 1.9 1.7
Fed-up feelings 1.4 2.6 9.8 2.7 1.6 -0.0 0.0 1.1 1.2 -1.0 -0.7 3.1 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 3.3 1.7 1.6 0.1 0.0 0.0 0.9 -1.8 0.4 1.8 -0.1
Relative age voice broke 0.7 1.1 3.6 0.7 0.6 1.3 0.0 0.5 1.9 -1.3 -0.3 1.7 -0.2
Taking other prescription medications 0.9 1.4 4.5 1.0 2.1 0.5 0.0 0.3 0.1 -1.9 0.8 1.9 -0.8
Age when periods started (menarche) 0.3 0.8 5.2 -0.1 0.8 -0.8 0.0 -0.7 0.9 -0.3 0.0 -0.2 -2.3
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 2.9 -1.4 -1.7 -1.2 0.0 0.8 0.4 -0.3 -0.3 0.4 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.8 0.3 0.7 -0.9 0.0 0.4 0.2 0.1 0.5 -0.2 -0.3
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 3.8 1.9 1.0 0.4 0.0 0.8 1.6 -2.0 -0.2 1.4 1.9
Qualifications: CSEs or equivalent 1.0 1.4 7.5 -0.8 -1.5 -0.6 0.0 2.7 0.0 0.6 -0.9 1.2 -0.6
Serious illness, injury or assault to yourself 1.4 1.7 5.2 2.3 0.7 1.2 0.0 -0.9 0.9 -1.7 1.4 1.6 0.8
High blood pressure 1.1 3.0 8.0 1.0 2.8 0.4 0.0 0.7 2.3 -2.6 0.6 2.6 -0.9
Hayfever, allergic rhinitis or eczema 0.6 1.3 3.6 0.9 1.1 1.3 0.0 -1.6 0.9 -1.5 0.2 -0.1 -1.9
Multivitamins +/- minerals 0.8 1.0 3.4 -1.8 -0.6 -1.2 0.0 0.3 -0.1 0.8 -0.1 -1.8 -0.7
Stomach or abdominal pain in last month 3.0 3.7 9.8 3.1 2.9 0.7 0.0 0.3 2.2 -2.7 0.4 2.4 0.1
Supplements: Glucosamine 0.5 0.7 3.2 -0.5 0.1 -0.4 0.0 -1.8 1.3 0.2 0.5 0.5 -0.9
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 5.8 -0.6 0.7 -0.1 0.0 -1.0 0.5 -1.0 0.0 -0.6 -2.4
Medication: Atenolol 0.6 0.8 2.6 1.5 0.7 -0.1 0.0 0.4 0.5 -0.7 0.8 1.6 1.0
Medication: Levothyroxine sodium 1.2 2.0 6.1 2.5 1.3 0.6 0.0 -0.2 1.1 -1.8 -0.3 2.3 1.5
Sitting height 0.2 1.4 7.1 -0.2 -2.7 0.6 0.0 -0.9 -0.7 1.7 0.3 -1.4 -0.5
Chronic bronchitis/emphysema (father) 0.6 0.7 2.9 1.0 0.0 1.7 0.0 -0.5 -0.3 -0.8 -1.1 -0.5 0.8
High blood pressure (mother) 2.4 3.3 8.2 1.5 1.4 2.5 0.0 -2.5 2.9 -2.7 -0.3 0.5 -1.1
Body mass index (BMI) 1.2 5.1 13.6 2.5 3.6 -0.0 0.0 1.0 2.6 -3.7 -0.4 3.0 1.3
Impedance of leg (left) 1.0 5.1 15.6 -1.8 -3.1 -0.8 0.0 1.1 -2.8 4.0 -2.0 -2.7 1.2
Leg predicted mass (left) 0.8 4.3 12.1 2.4 3.0 0.4 0.0 -0.7 2.5 -3.5 1.4 2.5 -0.7
Trunk fat mass 1.0 4.3 13.6 2.3 3.7 0.7 0.0 1.2 2.5 -2.9 0.3 2.4 1.2
Waist circumference 1.3 4.6 13.0 2.2 3.6 0.2 0.0 1.2 2.1 -3.5 0.3 2.8 1.5
Number of incorrect matches in round 0.7 1.2 5.2 0.3 1.9 2.3 0.0 -0.2 -0.0 -1.4 0.9 0.1 -0.2
Past tobacco smoking 1.1 2.1 5.2 -2.3 -1.9 -1.7 0.0 0.4 -0.7 1.6 0.2 -1.6 -1.8
Alcohol usually taken with meals 2.0 3.3 17.0 0.1 1.9 2.2 0.0 -0.3 1.2 -2.1 4.1 1.0 0.4
Nervous feelings 1.5 2.7 9.4 3.1 1.6 1.2 0.0 -1.6 2.2 -0.8 -1.8 1.3 1.0
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 6.2 2.5 0.9 -0.4 0.0 1.3 0.8 -1.4 -0.5 2.0 1.1
Hearing difficulty/problems with background noise 1.6 2.6 9.9 2.4 1.2 1.7 0.0 0.5 1.2 -1.9 -0.3 3.2 0.7
Hair/balding pattern: Pattern 2 0.4 0.5 1.8 -0.7 1.1 -0.8 0.0 0.2 -0.5 0.2 1.3 0.3 -0.6
Had menopause 0.6 0.7 3.0 -0.1 1.5 0.6 0.0 -0.3 0.6 -0.8 1.7 0.6 -0.5
Had other major operations 1.2 1.5 3.7 1.0 1.6 1.9 0.0 0.2 0.8 -1.3 1.8 1.2 -0.6
Forced vital capacity (FVC) 0.7 2.8 5.9 -2.4 -2.2 -0.8 0.0 -0.8 -1.6 1.7 0.3 -2.3 -2.2
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 1.6 0.2 -0.2 0.0 0.0 1.2 0.5 -0.0 0.2 0.5 -0.2
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.4 0.6 -1.2 1.1 0.0 0.2 -1.0 0.5 -0.1 -0.7 0.2
Qualifications: None of the above 0.3 0.6 2.9 0.5 0.5 -0.1 0.0 1.1 -0.4 -0.8 -0.3 1.7 -0.8
Financial difficulties in last 2 years 1.6 2.2 7.8 -0.1 0.1 -1.9 0.0 1.9 0.2 -1.7 -0.4 2.8 1.9
Mouth/teeth dental problems 0.8 1.2 3.9 -1.2 -0.8 -0.3 0.0 -2.0 -0.4 1.2 -0.5 -1.3 -1.5
Heart attack 1.8 2.3 14.7 2.1 -0.6 1.0 0.0 -1.2 0.3 0.3 -1.0 -0.2 3.8
Allergy 0.8 1.8 4.3 -0.7 -1.4 -1.5 0.0 2.1 -1.3 1.9 -0.3 0.2 2.1
Pain all over the body in last month 1.0 1.1 3.6 1.5 1.9 0.0 0.0 0.9 0.3 -1.1 -0.3 1.1 1.3
Diabetes (self-reported) 1.0 1.5 7.8 -0.5 -0.4 -1.6 0.0 1.9 0.4 0.2 -2.8 -0.2 0.4
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 7.2 -2.7 -1.6 -0.3 0.0 0.7 -1.5 1.5 -0.4 -2.1 -1.4
Medication: Ramipril 0.5 0.7 2.6 0.2 -0.1 -0.4 0.0 -0.7 -0.6 0.9 -1.4 -0.7 1.6
Medication: Simvastatin 1.5 2.2 8.7 -0.3 -1.0 -1.1 0.0 0.1 -1.1 1.9 -2.5 0.2 3.0
Fluid intelligence score 0.7 1.4 5.8 -0.9 -1.0 -1.3 0.0 -1.9 0.2 1.1 0.6 -2.4 -0.0
Illnesses of siblings 2.5 3.5 6.7 -1.3 -2.6 -2.4 0.0 -1.3 -1.7 2.6 -2.0 -2.2 1.1
Neuroticism score 3.5 7.3 18.9 4.3 3.9 -0.3 0.0 -0.8 3.5 -3.5 0.2 3.5 1.2
Weight 0.9 4.4 11.6 2.7 3.4 0.4 0.0 0.2 2.6 -3.2 0.4 2.6 0.7
Impedance of arm (right) 0.3 1.4 4.6 -2.2 -0.5 1.2 0.0 -0.2 -0.4 1.6 1.0 -1.9 -0.5
Arm fat percentage (right) 0.9 3.6 11.3 1.5 3.4 0.7 0.0 1.3 2.2 -3.0 0.0 2.1 1.4
Trunk fat-free mass 0.4 2.1 5.4 2.3 1.5 0.3 0.0 -1.4 1.5 -2.2 0.5 1.7 -0.7
Hip circumference 0.7 2.9 9.3 1.9 3.0 0.7 0.0 -0.1 2.1 -2.7 1.1 1.6 0.4
Time employed in main current job 0.3 0.3 1.6 -0.5 -0.8 -1.3 0.0 0.3 -0.6 0.5 -0.0 0.4 0.1
Alcohol intake versus 10 years previously 1.4 2.1 5.4 2.0 1.2 0.8 0.0 0.0 2.3 -2.0 0.2 2.3 -0.0
Father’s age at death 1.0 1.3 7.8 -0.3 1.5 0.2 0.0 -1.4 1.1 -0.0 2.8 0.1 0.3
Worrier / anxious feelings 2.4 4.5 13.8 2.0 3.7 -0.4 0.0 -1.1 3.3 -2.8 0.7 2.2 -1.2
Frequency of tiredness / lethargy in last 2 weeks 4.1 6.7 17.0 3.0 3.9 0.8 0.0 0.2 4.1 -3.6 0.6 3.4 -0.4
Falls in the last year 1.0 1.3 5.3 2.3 1.6 -0.7 0.0 0.0 0.6 -1.4 0.1 0.8 1.4
Hair/balding pattern: Pattern 3 0.9 1.3 6.5 0.7 -0.3 1.6 0.0 -1.0 0.7 0.4 -1.3 -0.3 2.6
Number of live births 0.8 1.2 3.0 1.4 0.3 0.6 0.0 0.0 0.9 -0.8 -1.7 1.7 1.5
Forced expiratory volume in 1-second (FEV1) 1.0 3.2 10.0 -2.1 -2.8 0.2 0.0 -0.5 -1.8 1.7 -0.2 -3.2 -1.9
Pulse rate 0.5 0.8 2.4 -1.4 -0.8 -1.4 0.0 0.5 -0.0 0.5 -1.6 -0.5 0.6
Happiness 0.3 0.4 1.5 0.7 0.8 0.2 0.0 -1.0 1.2 -0.1 0.3 -0.3 -0.3
Noisy workplace 0.5 0.6 3.5 0.9 -0.2 0.1 0.0 0.8 0.4 0.3 0.3 1.9 0.7
Qualifications: A levels/AS levels or equivalent 1.1 2.4 9.4 -1.3 -1.3 0.0 0.0 -2.2 -0.4 -0.0 2.4 -3.1 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 3.2 -1.8 -0.8 0.9 0.0 -0.0 0.6 0.9 0.7 0.1 0.3
Mouth/teeth dental problems: Dentures 0.6 1.0 2.5 -0.9 -1.6 -0.6 0.0 0.7 -1.2 1.3 -0.4 -1.0 1.3
Asthma 0.1 0.2 0.7 -0.2 -0.8 -0.7 0.0 -0.7 -0.0 -0.4 -0.0 -0.3 0.0
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 2.1 0.6 0.1 0.1 0.0 0.7 -1.5 -0.5 -1.1 0.5 -0.5
Medication: Cholesterol lowering 1.5 2.3 10.5 0.2 -1.1 0.3 0.0 1.5 -1.1 1.4 -3.2 0.2 2.5
Depression (self-reported) 2.0 2.4 12.9 -0.9 2.3 -0.0 0.0 0.6 1.1 -1.0 1.4 0.4 -3.6
Medication: Lansoprazole 1.0 1.1 2.9 0.9 1.6 0.9 0.0 0.1 1.0 -1.0 0.5 1.4 -1.7
Prospective memory result 1.0 1.2 4.4 0.6 1.7 1.9 0.0 -0.4 0.4 0.1 0.6 0.3 -2.1
Lung cancer (father) 0.3 0.3 2.5 0.2 0.4 0.2 0.0 1.6 0.2 0.0 -0.5 0.5 0.2
Illnesses of mother 1.1 1.3 4.5 -0.9 -0.5 -2.0 0.0 1.7 -2.1 0.7 0.5 -0.4 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.1 11.4 -3.4 -2.4 0.5 0.0 0.5 -2.0 2.2 0.2 -2.6 -2.8
Pulse wave Arterial Stiffness index 0.5 0.5 3.3 0.5 -0.8 -0.2 0.0 -0.3 0.0 0.4 -0.5 -0.8 1.8
Impedance of arm (left) 0.4 1.9 5.8 -1.9 -0.7 1.2 0.0 -0.5 -1.0 2.1 1.1 -2.4 -0.8
Arm fat mass (right) 1.0 4.2 12.1 2.1 3.5 0.4 0.0 0.9 2.3 -3.5 -0.1 2.4 1.1
Trunk predicted mass 0.4 2.0 5.3 2.3 1.4 0.4 0.0 -1.5 1.5 -2.2 0.5 1.7 -0.6
Standing height 0.1 1.2 4.2 0.6 -0.3 1.1 0.0 -2.0 0.5 0.6 1.8 -0.4 -1.3
Length of working week for main job 0.4 0.4 1.0 0.8 -0.0 0.3 0.0 0.2 0.8 -0.3 0.8 0.8 -1.0
Exposure to tobacco smoke at home 0.6 0.7 2.0 0.9 0.8 -0.6 0.0 1.3 0.2 -1.4 -0.7 1.0 0.1
Breastfed as a baby 1.1 1.4 5.2 -1.4 0.6 -0.6 0.0 -1.7 2.3 0.6 0.9 0.2 -1.4
Tense / ‘highly strung’ 0.9 1.4 3.3 1.2 1.7 -0.7 0.0 1.8 0.4 -1.4 1.6 1.1 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.4 10.8 3.3 2.3 -1.1 0.0 1.0 0.8 -1.1 -1.1 1.7 0.2
Hair/balding pattern: Pattern 4 0.1 0.3 0.7 -0.1 -0.6 0.5 0.0 0.7 -0.4 0.6 0.3 -0.7 -0.8
Birth weight of first child 1.8 3.3 8.1 -1.4 -2.3 -2.5 0.0 -0.7 -1.8 2.3 -1.2 -2.8 0.4
Peak expiratory flow (PEF) 0.9 2.1 6.7 -1.6 -1.9 1.6 0.0 -0.4 -0.9 0.8 1.0 -2.6 -1.7
Pulse wave reflection index 0.1 0.2 0.5 0.7 -0.5 0.1 0.0 0.1 -0.3 0.1 0.2 -0.3 0.7
Ever highly irritable/argumentative for 2 days 0.7 0.8 4.6 2.1 0.5 0.5 0.0 0.2 1.0 -0.8 0.0 1.2 -0.1
Loud music exposure frequency 0.9 0.9 2.2 -0.7 0.3 -1.4 0.0 1.5 -1.1 -0.6 0.4 1.1 -1.3
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 5.8 -0.9 -1.0 -0.4 0.0 -1.0 -0.3 1.5 0.2 -2.4 -0.0
Mouth/teeth dental problems: Bleeding gums 1.9 2.5 6.6 1.7 1.6 1.4 0.0 2.5 0.1 -1.7 0.9 2.6 1.1
Blood clot in the leg (DVT) 0.4 0.5 1.4 -0.9 0.6 0.6 0.0 0.4 0.8 -0.8 1.2 0.2 -0.6
Medication: Paracetamol 1.1 1.8 4.1 0.7 1.6 1.8 0.0 -0.8 0.7 -2.0 1.2 1.2 -2.0
Headache pain in last month 0.7 1.2 3.2 1.8 1.7 0.2 0.0 -1.4 0.7 -1.5 0.0 0.5 -0.6
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.2 -0.7 -0.4 -0.9 0.0 -1.1 -0.4 -0.4 0.9 -1.5 -1.0
Glaucoma (self-reported) 0.9 1.0 3.8 0.5 2.0 0.9 0.0 -0.0 1.0 -0.6 0.7 0.2 -1.9
Gout (self-reported) 0.8 1.1 3.8 0.9 1.9 0.6 0.0 -0.8 1.4 -1.2 -0.8 -0.4 -0.8
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 2.2 1.5 0.4 -0.2 0.0 -0.4 -0.2 -0.3 -1.4 0.5 1.3
Medication: Amlodipine 1.2 1.6 6.3 -0.3 -0.9 0.2 0.0 0.7 -0.9 2.5 -2.0 -0.3 1.9
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.6 -0.3 -0.5 0.0 0.0 0.6 0.4 -0.4 0.2 0.2 -0.8
Birth weight 0.7 1.6 4.8 -0.6 -1.5 0.1 0.0 -2.2 -1.6 1.5 -0.5 -1.9 0.2
Chronic bronchitis/emphysema (mother) 1.1 1.3 3.7 1.2 0.4 -0.3 0.0 -1.9 1.9 -1.5 -0.7 0.7 0.8
High blood pressure (siblings) 1.2 1.8 6.0 0.6 1.9 2.5 0.0 0.7 0.7 -1.6 0.7 1.7 -0.9
Forced vital capacity (FVC), Best measure 0.8 3.1 9.5 -3.1 -1.6 0.1 0.0 -0.5 -1.5 2.1 0.9 -1.8 -2.8
Body fat percentage 1.1 4.2 13.0 2.0 3.6 0.5 0.0 1.9 2.3 -2.7 -0.1 2.3 1.8
Leg fat percentage (right) 1.1 4.1 8.4 2.2 2.5 -1.0 0.0 2.7 1.7 -1.9 -1.0 2.5 2.9
Arm fat-free mass (right) 0.5 2.5 8.5 2.9 1.8 0.2 0.0 -0.7 1.6 -2.3 -0.3 2.2 -0.1
Exposure to tobacco smoke outside home 0.6 0.7 3.7 1.9 -0.3 -0.8 0.0 0.7 -1.1 0.3 -0.5 0.7 0.7
Comparative body size at age 10 0.5 1.3 4.7 0.3 1.6 -0.1 0.0 -1.9 0.3 -0.9 0.4 -0.7 -2.2
Number of full brothers 0.6 0.7 3.4 0.7 -0.0 -0.5 0.0 -0.3 1.9 -0.0 -1.8 0.3 -0.1
Worry too long after embarrassment 1.0 1.7 4.1 1.7 1.1 -0.1 0.0 -1.9 2.0 -1.9 -0.3 0.8 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 7.0 2.5 2.6 -0.5 0.0 -0.5 1.5 -1.9 -0.7 1.0 -0.1
Wheeze or whistling in the chest in last year 0.6 1.1 2.7 -0.9 1.3 -1.5 0.0 0.1 1.1 -1.6 1.1 0.2 -1.2
Number of children fathered 1.6 1.8 4.1 1.0 1.7 1.5 0.0 0.0 0.7 -0.8 1.7 2.0 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 2.5 1.4 1.4 0.6 0.0 -0.4 0.3 -1.5 -1.2 1.6 -0.1
Age at first live birth 0.7 1.2 2.9 -1.3 -0.9 -1.1 0.0 -1.7 -1.0 1.4 1.5 -0.7 0.5
Pulse wave peak to peak time 0.5 0.5 3.0 -0.2 1.0 0.3 0.0 -0.2 0.2 -0.5 0.5 0.9 -1.7
Health satisfaction 1.3 1.7 6.2 1.3 0.8 -0.4 0.0 1.6 1.5 -1.3 0.4 2.5 -1.3
Shortness of breath walking on level ground 0.6 0.7 3.0 1.7 -0.5 -0.3 0.0 -0.3 0.4 0.3 -1.0 -0.1 1.5
Qualifications: College or University degree 1.4 4.4 19.5 -1.4 -1.2 0.2 0.0 -4.4 0.3 0.5 2.1 -3.8 1.4
Eye problems/disorders: None of the above 1.2 1.4 4.8 -1.6 -0.8 1.0 0.0 0.4 -1.1 2.2 -0.3 -1.3 -1.4
Mouth/teeth dental problems: Loose teeth 1.6 2.0 6.3 1.7 0.2 0.6 0.0 2.5 0.1 -0.6 -0.6 2.3 2.0
Emphysema/chronic bronchitis 0.8 0.9 5.0 -0.5 0.7 1.0 0.0 2.2 0.6 -1.0 -0.1 1.1 0.1
Medication for pain relief, constipation, heartburn 0.9 1.5 4.2 -2.0 -1.7 -2.1 0.0 0.5 -0.0 1.6 0.5 -0.6 -0.2
Neck or shoulder pain in last month 2.1 3.1 8.7 1.6 2.9 -0.5 0.0 1.2 2.9 -1.7 -0.1 2.3 -1.0
Medication: Blood pressure 0.2 0.3 1.4 0.3 0.6 1.2 0.0 -0.1 -0.2 1.1 -0.1 0.4 -0.0
Angina (self-reported) 0.8 1.0 3.5 0.7 -1.0 -0.9 0.0 -0.5 0.6 1.0 -1.5 -0.1 1.9
Migraine (self-reported) 0.2 0.2 0.7 0.5 -0.5 -0.1 0.0 -0.5 -0.7 0.1 -0.9 0.2 -0.4
Medication: Ibuprofen 0.6 0.7 4.2 0.7 0.0 -0.0 0.0 0.7 -2.0 -0.4 -1.2 0.7 -0.1
Medication: Allopurinol 1.2 1.6 4.9 1.4 2.2 0.9 0.0 -0.8 2.0 -1.1 -1.4 -0.1 -0.5
Medication: Omeprazole 2.2 2.6 7.7 2.5 2.3 0.3 0.0 0.6 1.3 -2.8 -0.6 1.9 0.6
Medication: Seretide 50 evohaler 0.7 0.8 2.7 0.1 -0.3 0.8 0.0 -1.0 -0.9 1.2 0.4 -1.2 -1.6
Mean time to correctly identify matches 0.4 0.7 1.2 -1.1 -0.8 1.0 0.0 -1.0 -0.7 1.1 0.6 -0.8 0.8
Heart disease (mother) 1.3 1.6 6.7 1.0 1.3 2.6 0.0 -2.1 0.9 -0.7 -0.1 -0.8 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 2.2 1.0 -1.1 1.1 0.0 1.5 1.0 0.1 -0.7 0.9 0.8
Whole body fat mass 1.0 4.3 12.8 2.3 3.6 0.3 0.0 1.1 2.5 -3.1 0.1 2.4 1.4
Leg fat mass (right) 1.1 4.1 10.1 2.4 3.2 -0.7 0.0 1.5 2.0 -2.9 -0.5 2.4 1.9
Arm predicted mass (right) 0.6 3.1 10.5 3.2 2.1 0.3 0.0 -0.6 1.8 -2.6 -0.4 2.4 0.3
Pulse rate, automated reading 0.2 0.5 1.7 -1.2 -0.1 -1.3 0.0 0.1 -0.4 0.7 -1.0 -0.7 0.3
Alcohol intake frequency. 0.2 0.5 2.9 0.1 0.3 -0.8 0.0 -0.8 1.7 -0.5 -0.4 0.7 0.6
Comparative height size at age 10 0.2 1.0 3.3 0.3 0.1 1.3 0.0 -1.8 -0.3 -0.0 1.8 0.4 -1.0
Number of full sisters 0.4 0.5 2.6 -0.2 0.3 1.6 0.0 1.2 0.3 -0.3 0.7 -0.5 -0.4
Suffer from ‘nerves’ 0.4 0.7 2.4 1.6 0.3 -1.0 0.0 -0.4 1.2 0.3 0.0 1.3 0.2
Overall health rating 1.8 3.9 17.9 4.2 2.2 1.6 0.0 1.6 1.4 -1.9 -0.4 2.2 0.6
Chest pain or discomfort 3.7 5.4 21.3 4.6 2.0 0.8 0.0 0.6 3.4 -2.0 -1.3 2.1 2.3
Had major operations 1.2 1.4 4.1 0.4 1.0 1.8 0.0 0.4 0.2 -1.5 2.0 1.7 0.0
Age at last live birth 0.5 0.7 3.4 -0.7 -0.5 0.4 0.0 -1.8 -0.3 0.1 1.3 -0.7 0.5
Family relationship satisfaction 0.5 0.6 2.5 1.4 0.4 -1.6 0.0 -0.5 0.3 -0.2 -1.2 -0.0 0.3
Leg pain on walking 1.1 1.3 4.2 1.1 1.4 0.7 0.0 0.9 1.1 -1.1 1.4 2.0 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 5.2 -0.0 1.1 -0.6 0.0 1.1 1.0 -1.8 -0.3 2.3 -0.1
Commuting to job workplace: Car/motor vehicle 1.3 1.5 5.8 0.4 -2.4 1.1 0.0 1.6 -0.0 1.7 -1.4 0.2 -0.4
Illness, injury, bereavement, stress in last 2 years 1.6 2.0 8.0 -1.3 -0.4 -0.1 0.0 -0.9 -0.7 1.8 0.6 -2.8 -2.2
Medication: Aspirin 0.6 0.8 2.6 0.7 0.6 0.5 0.0 -1.0 1.0 0.9 -1.1 -0.4 1.6
Supplements: Vitamin C 0.4 0.5 2.3 0.4 1.5 0.7 0.0 -0.8 0.7 -0.9 -0.4 -0.2 0.6
Knee pain experienced in last month 1.7 2.7 8.4 2.8 1.4 0.2 0.0 1.1 1.7 -1.0 1.0 2.9 -1.7
Hypertension (Self-reported) 0.8 2.3 6.8 0.4 2.6 0.2 0.0 0.0 1.8 -2.3 0.8 2.1 -1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 4.8 -0.4 -0.1 -0.2 0.0 2.2 0.6 -0.2 0.3 0.9 -0.8
Illnesses of father: Heart disease 0.9 1.2 4.2 0.7 -1.1 1.3 0.0 0.9 0.2 0.2 -2.0 -0.6 1.7
Illnesses of siblings: Diabetes 0.5 0.6 1.5 0.4 1.2 0.2 0.0 1.2 -0.8 -0.8 1.2 -0.4 -0.5
Smoking status: Previous 1.7 2.5 6.9 2.6 2.0 2.1 0.0 0.0 0.8 -1.6 -0.2 2.1 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 2.7 -0.0 -0.0 -0.3 0.0 0.3 -0.8 0.6 -0.3 -0.0 -1.7
Whole body fat-free mass 0.5 3.0 8.2 2.4 2.2 0.4 0.0 -1.1 2.0 -2.9 0.8 2.1 -0.6
Leg fat-free mass (right) 0.7 3.6 10.0 2.1 2.7 0.5 0.0 -1.3 2.4 -3.2 1.1 2.0 -0.8
Arm fat percentage (left) 0.9 3.6 12.0 1.7 3.5 0.6 0.0 1.4 2.1 -2.9 -0.0 2.1 1.4
Average weekly red wine intake 0.4 0.6 2.0 -0.0 -0.3 1.2 0.0 -0.7 -0.6 -1.3 1.4 -0.3 0.3
Handedness (chirality/laterality): Left-handed 1.0 1.2 4.1 -0.4 -0.5 -2.0 0.0 1.5 -1.4 0.9 0.6 -0.2 1.4
Mood swings 2.8 5.1 14.1 3.8 3.4 0.3 0.0 -0.2 2.9 -2.8 -0.2 2.7 1.1
Loneliness, isolation 3.4 4.7 14.4 2.9 2.3 -2.1 0.0 0.4 2.4 -2.3 0.8 3.8 1.6
Long-standing illness, disability or infirmity 2.1 3.1 10.8 2.2 2.4 0.8 0.0 0.5 1.9 -3.3 1.0 2.1 -0.3
Ever had bowel cancer screening 1.5 1.8 5.3 0.8 1.5 2.3 0.0 0.5 2.0 -1.2 1.1 1.1 -0.9
Diabetes diagnosed by doctor 0.7 1.1 5.8 -0.2 0.1 -1.1 0.0 1.7 1.0 -0.3 -2.4 0.2 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 2.4 0.2 -0.7 1.6 0.0 0.6 -0.1 -0.1 0.9 0.1 -0.9
Friendships satisfaction 0.7 0.9 2.2 0.3 0.5 1.5 0.0 1.2 1.5 0.6 0.8 1.3 -0.0
Qualifications: nursing, teaching 0.7 1.1 4.9 0.2 0.3 1.1 0.0 -1.5 0.2 -0.6 2.2 -1.4 -0.1
Commuting to job workplace: Walk 0.5 0.6 2.4 -0.3 1.6 -0.5 0.0 -0.0 0.5 0.0 1.0 0.0 1.2
Eye problems/disorders: Cataract 0.9 1.0 2.7 0.8 0.3 -1.1 0.0 -0.5 1.6 -1.5 1.3 0.7 0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.8 1.3 1.1 -0.1 0.0 0.0 0.4 -0.5 0.2 -0.3 0.7
Medication for cholesterol 0.3 0.5 2.3 -0.2 -1.1 -0.1 0.0 0.2 -0.6 1.5 0.6 -0.8 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 3.5 1.5 -0.3 1.9 0.0 0.2 -1.4 -0.2 -0.1 0.1 0.7
Back pain experienced in last month 3.2 4.7 17.1 4.1 2.9 1.9 0.0 0.5 2.5 -2.6 1.0 1.9 -0.3
Mineral and other dietary supplements 0.4 0.5 3.5 -0.2 0.2 -0.8 0.0 0.7 -1.9 0.4 -0.4 -0.2 0.3
Breast cancer (self-reported) 1.9 2.2 11.8 3.4 0.7 1.0 0.0 -0.6 1.6 -0.8 -0.4 0.8 2.0
Asthma (self-reported) 0.1 0.2 0.6 0.3 -0.5 -0.5 0.0 -0.8 0.3 -0.8 -0.2 0.0 0.2
Osteoporosis (self-reported) 2.4 3.0 6.1 1.0 1.9 2.3 0.0 -1.8 2.2 -1.9 1.2 0.9 -2.5
Osteoarthritis (self-reported) 0.8 1.1 3.7 1.2 1.9 -0.8 0.0 -0.3 0.3 -1.9 -0.2 1.0 -0.1
Medication: Aspirin 0.7 0.9 4.0 0.9 0.2 0.4 0.0 -0.8 0.6 1.3 -1.2 -0.6 2.0
Medication: Gliclazide 1.8 2.1 13.8 1.4 -0.4 -0.3 0.0 -0.0 0.7 0.9 -3.7 0.4 1.8
Illnesses of father: None of the above (group 1) 0.3 0.4 1.1 -0.5 -0.1 -0.5 0.0 1.1 -1.0 1.0 0.2 -0.6 -0.5
Smoking status: Current 0.4 0.6 3.6 -0.9 -0.3 -1.9 0.0 1.2 -0.5 -0.3 -0.1 -0.3 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.6 5.4 16.5 -4.1 -1.9 -1.2 0.0 0.6 -3.4 2.9 -0.3 -3.0 -1.7
Whole body water mass 0.5 3.0 7.9 2.5 2.2 0.5 0.0 -1.2 1.9 -2.8 0.7 2.1 -0.4
Leg predicted mass (right) 0.7 3.6 10.0 2.2 2.8 0.5 0.0 -1.4 2.4 -3.2 1.1 2.0 -0.9
Arm fat mass (left) 1.0 4.2 12.4 2.2 3.5 0.6 0.0 0.8 2.4 -3.4 0.0 2.4 1.1
Number of self-reported non-cancer illnesses 0.8 1.4 4.7 1.3 1.6 0.4 0.0 0.9 1.2 -2.2 -0.3 1.6 -0.3
Average weekly champagne plus white wine intake 0.4 0.5 2.6 -0.1 1.6 -0.0 0.0 -1.1 0.9 -0.1 0.5 -0.0 -0.4
Miserableness 1.8 3.1 6.8 2.5 2.6 -0.3 0.0 -0.1 2.5 -2.2 -1.0 2.5 0.1
Guilty feelings 1.8 2.7 8.0 2.8 2.5 -0.3 0.0 -1.0 1.6 -2.7 0.2 1.3 -0.1
Wears glasses or contact lenses 1.3 1.5 6.2 -0.2 1.1 2.5 0.0 -1.7 0.4 -0.1 2.1 -0.2 -0.2
Ever taken oral contraceptive pill 0.8 0.9 3.2 1.0 -0.4 -1.8 0.0 0.6 -1.0 0.4 -1.0 0.6 1.4
Hearing aid user 0.4 0.5 1.8 0.1 0.3 0.5 0.0 -0.6 -0.4 -0.2 -1.3 -0.5 1.4
Mother’s age at death 1.3 1.7 8.4 -0.8 -0.9 2.0 0.0 0.8 -0.8 0.7 2.9 -0.3 -1.0
Financial situation satisfaction 0.4 0.5 2.0 -0.5 -0.6 0.0 0.0 1.4 0.3 -0.1 -0.8 0.8 0.8
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.2 -1.5 -0.2 -1.2 0.0 -1.4 -0.1 0.2 0.1 -0.5 0.2
Commuting to job workplace: Public transport 0.5 0.5 2.7 -0.5 0.5 -1.6 0.0 -1.1 0.1 0.7 0.4 -0.6 0.1
Eye problems/disorders: Glaucoma 0.3 0.3 1.5 0.0 1.2 0.0 0.0 -0.1 0.2 -0.8 0.6 -0.7 -0.2
Medication: Blood pressure 0.5 0.9 3.1 -0.2 1.2 -0.1 0.0 1.2 0.8 -1.3 -0.3 1.8 -0.7
Pain type(s) experienced in last month: Hip pain 1.4 1.7 5.9 1.1 1.7 -0.5 0.0 0.9 0.9 -1.4 1.7 2.4 -0.8
Supplements: Fish oil (including cod liver oil) 0.3 0.4 2.1 -0.0 -0.6 1.5 0.0 0.5 0.9 -0.2 -0.3 0.5 -0.6
High cholesterol (Self-reported) 3.2 5.6 26.7 0.6 -2.0 0.7 0.0 0.4 -1.6 2.1 -4.0 -1.2 5.2
Medication: Bendroflumethiazide 0.5 0.7 3.5 -0.9 1.9 -0.7 0.0 0.1 -0.1 -0.7 1.1 0.4 -0.6
Medication: Paracetamol 1.7 2.6 8.9 1.2 2.2 1.6 0.0 -0.2 0.6 -3.0 1.8 1.9 -1.1
Medication: Lisinopril 0.3 0.4 1.9 -0.2 0.3 -1.4 0.0 -0.5 0.1 -0.5 -0.4 0.8 0.9
Medication: Atorvastatin 1.9 2.3 13.4 1.4 -1.0 2.0 0.0 0.9 -0.5 0.8 -0.8 -0.3 3.7
Illnesses of father: High blood pressure 2.1 2.5 6.7 0.7 2.3 -0.9 0.0 -0.4 2.6 -1.9 1.8 2.1 -0.9
Alcohol drinker status: Never 1.4 1.6 5.3 -0.3 -1.4 -2.1 0.0 -2.3 0.3 1.4 0.5 -1.3 0.8
Ever smoked 0.8 1.4 4.4 1.3 1.4 2.1 0.0 -1.4 0.3 -1.1 -0.8 0.4 1.4
Basal metabolic rate 0.6 3.2 9.1 2.5 2.5 0.3 0.0 -0.9 2.2 -3.0 0.7 2.2 -0.3
Leg fat percentage (left) 1.0 3.7 7.7 2.1 2.5 -0.8 0.0 2.4 1.6 -1.8 -1.1 2.2 2.8
Arm fat-free mass (left) 0.6 3.1 7.7 2.8 2.3 0.2 0.0 -0.9 2.0 -2.8 -0.3 2.2 0.5
Number of operations (self-reported) 1.4 2.1 5.0 0.8 1.7 2.2 0.0 0.4 0.7 -1.9 2.0 2.1 -0.5
Average weekly beer plus cider intake 0.5 0.7 3.3 -0.6 -0.6 -0.6 0.0 -0.1 -0.0 1.1 -0.4 -1.0 -1.8
Irritability 2.3 3.9 11.0 2.9 3.3 -0.1 0.0 -0.2 1.6 -2.6 0.7 2.9 1.0
Risk taking 1.3 2.0 7.2 1.7 1.0 0.2 0.0 0.5 1.4 -2.7 0.8 1.8 1.4
Ever had prostate specific antigen (PSA) test 0.6 0.6 1.8 -0.8 -1.3 -0.3 0.0 1.4 -1.0 1.1 -0.3 -0.1 -0.1
Fractured/broken bones in last 5 years 1.0 1.2 3.0 1.3 1.7 0.5 0.0 -1.4 0.6 -1.5 0.4 0.4 -1.6
Age started oral contraceptive pill 1.0 1.2 3.4 -0.7 -0.8 1.5 0.0 -0.8 0.5 1.2 1.1 -1.9 -1.3
Diastolic blood pressure, automated reading 0.4 1.1 3.8 0.4 0.3 -1.2 0.0 1.1 0.3 -1.6 0.0 1.9 -1.3
Ever depressed for a whole week 0.1 0.2 0.7 0.8 -0.2 0.4 0.0 0.3 -0.7 0.1 -0.1 -0.3 0.4
Unable to work because of sickness or disability 1.1 1.4 4.5 0.5 -0.3 0.1 0.0 2.0 -2.1 0.7 -1.6 1.2 0.9
Commuting to job workplace: Cycle 0.5 0.7 1.8 1.1 1.1 -0.1 0.0 -0.9 0.8 -0.8 0.5 0.3 1.3
Myopia 0.8 1.1 3.2 0.9 1.6 -0.2 0.0 -1.6 1.3 -1.8 -0.1 -0.9 0.2
Vascular/heart problems diagnosed by doctor 0.7 1.9 5.5 -1.2 -2.0 -0.5 0.0 -0.5 -2.0 1.9 -0.0 -2.4 -0.5
Cholesterol lowering medication 1.2 1.8 10.2 0.5 -1.2 0.7 0.0 -0.5 -0.3 0.7 -2.0 -0.7 3.2
Medication: Omeprazole (e.g. Zanprol) 1.9 2.4 7.2 2.7 2.5 1.0 0.0 0.1 0.9 -2.3 -1.2 1.2 0.1
Pain experienced in last month 3.3 5.5 13.8 -3.4 -3.3 -1.2 0.0 -1.7 -2.5 2.6 -0.7 -3.7 1.1
Supplements: Calcium 0.7 0.8 2.9 0.3 0.8 0.4 0.0 -1.7 1.1 -0.8 0.6 -0.2 -1.4
Basal cell carcinoma (self-reported) 0.3 0.4 1.1 -0.4 0.2 -1.0 0.0 0.2 0.5 0.3 0.6 0.9 -1.1
Heart attack/myocardial infarction (self-reported) 1.9 2.5 16.5 2.2 -0.3 1.2 0.0 -0.9 0.3 0.1 -1.0 0.1 4.1
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.3 -0.3 0.9 0.7 0.0 0.2 0.7 -1.0 1.1 0.4 -0.4
Heart disease (siblings) 0.4 0.4 1.5 0.7 0.1 0.0 0.0 0.3 1.2 0.1 1.1 0.8 -0.8
Alcohol drinker status: Previous 0.4 0.5 2.0 1.4 0.2 0.8 0.0 0.3 0.2 -0.6 -1.0 0.6 0.6
Pack years of smoking 0.1 0.2 0.5 0.1 -0.4 -0.2 0.0 -0.4 -0.6 0.7 -0.6 0.4 -0.1
Impedance of whole body 0.5 2.4 8.5 -2.0 -1.8 0.7 0.0 0.6 -1.6 2.9 0.0 -2.3 -0.0
Leg fat mass (left) 1.0 3.8 10.3 2.5 3.2 -0.3 0.0 1.2 2.1 -2.8 -0.6 2.2 1.7
Arm predicted mass (left) 0.6 3.0 7.8 2.7 2.3 0.4 0.0 -1.0 1.9 -2.8 -0.1 2.2 -0.0