Hub : Traits :

LDL Cholesterol

360 significantly associated models · 133 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 24871730 26855401 8 2 2.3e-12 1.9e-10 2.9e-01 97 LDLRAP1 TMEM50A
2 1 54527647 56375280 2 1 6.3e-13 1.9e-28 3.3e-22 23 USP24
3 1 61510619 63844736 3 1 6.1e-18 2.6e-18 1.0e+00 100 DOCK7
4 1 92277843 94120642 2 1 6.7e-08 1.5e-07 2.8e-01 96 EVI5
5 1 108654479 111016796 18 12 3.9e-172 9.7e-171 1.0e+00 100 AMIGO1 GPSM2 GSTM1 GSTM3 PSRC1 RP4-735C1.4 RP5-1160K1.3 SORT1 STXBP3 SYPL2 TMEM167B
6 1 220226732 221656366 1 1 3.2e-07 5.6e-11 4.6e-07 41 MARC2
7 2 20062043 21958745 2 2 6.2e-114 4.5e-114 1.0e+00 100 APOB HS1BP3
8 2 43302571 44735953 1 1 3.4e-08 1.7e-47 3.1e-47 1 DYNC2LI1
9 2 62211083 63968655 1 1 2.5e-08 3.3e-07 1.3e-02 76 EHBP1
10 3 11900101 13321852 1 1 2.4e-08 2.2e-07 6.7e-02 88 MKRN2
11 5 73626450 75704085 8 12 7.2e-32 5.1e-45 NaN NaN ANKDD1B ANKRD31 COL4A3BP GCNT4 POC5 POLK
12 5 155651738 157087764 1 1 8.8e-21 1.9e-22 1.0e+00 100 TIMD4
13 6 33856903 35362848 1 1 3.6e-08 4.7e-07 4.2e-01 98 C6orf106
14 6 115569351 117264735 3 1 2.2e-09 2.9e-09 1.0e+00 100 FRK
15 7 43885849 45318389 3 2 8.0e-09 1.0e-09 5.9e-01 99 DDX56 NPC1L1
16 8 58778118 60190231 1 1 3.2e-07 6.7e-09 3.5e-03 75 SDCBP
17 8 144243392 145785009 4 1 2.9e-12 5.6e-12 1.0e+00 100 PLEC
18 9 135629944 137034272 1 2 3.1e-08 2.3e-21 3.1e-14 36 CACFD1
19 11 17923676 19345331 2 1 1.8e-07 2.9e-07 1.0e+00 100 SPTY2D1
20 11 60549966 62605067 9 1 1.1e-21 1.2e-21 1.0e+00 100 TMEM258
21 11 115953897 117800682 3 3 4.8e-16 1.5e-14 1.2e-03 82 PAFAH1B2 PCSK7 ZNF259
22 11 125134725 126914307 2 1 1.4e-08 1.2e-15 1.2e-10 35 DCPS
23 12 111193499 113517494 8 1 1.5e-09 1.5e-09 7.8e-03 81 ALDH2
24 12 120722064 122167693 2 2 3.8e-13 3.3e-15 1.1e-01 96 HNF1A OASL
25 13 32275990 33700374 1 1 1.5e-07 7.5e-08 1.4e-01 93 N4BP2L1
26 14 24179343 25582885 1 1 3.8e-08 4.9e-11 2.1e-04 68 NYNRIN
27 16 56330832 57810318 1 1 3.1e-10 1.6e-12 8.9e-05 69 NLRC5
28 16 71227328 72845749 5 3 3.6e-23 1.8e-22 1.0e+00 100 DHODH DHX38 HPR
29 17 26279731 27684579 1 1 1.5e-07 5.3e-05 6.4e-01 99 SDF2
30 17 44788310 46474610 5 1 1.3e-11 3.9e-09 4.2e-02 88 EFCAB13
31 19 9982334 12191233 11 11 4.5e-35 4.3e-117 NaN NaN AP1M2 C19orf80 CARM1 EPOR ILF3 LDLR SMARCA4
32 19 18333894 20451172 5 1 5.0e-20 6.7e-22 2.9e-03 90 ATP13A1
33 19 44149449 46547330 12 19 5.4e-59 8.7e-147 1.9e-127 13 BCAM BLOC1S3 CEACAM19 CTB-179K24.3 GEMIN7 KLC3 PVR PVRL2 TOMM40 ZNF112 ZNF229 ZNF285
34 19 48525507 49955222 2 1 5.0e-08 7.6e-08 1.0e+00 100 RASIP1
35 20 39108504 40683594 2 2 8.1e-16 3.4e-19 4.3e-04 84 LPIN3 ZHX3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 4.67 6 4 12.1 0.90 2.1e-03 BCAM CEACAM19 KLC3 PVR TOMM40 ZNF285
Alzheimer’s Disease (in father) 2.13 3 1 3.0 0.95 5.4e-02 CEACAM19 TOMM40 ZNF285
Alzheimer’s Disease (including proxy) 8.82 7 6 18.2 0.89 2.5e-04 BCAM CEACAM19 KLC3 PVR TOMM40 ZNF112 ZNF285
Crohns Disease (2017) 1.28 3 1 3.0 0.00 1.0e+00 RASIP1 TIMD4 TMEM258
Irritable Bowel Disease (IBD) 0.96 2 0 0.0 0.00 1.0e+00 RASIP1 TMEM258
Reaction Time 1.10 2 1 3.0 0.00 1.0e+00 ALDH2 CARM1
Verbal and Numeric Reasoning (VNR) 1.22 3 1 3.0 0.09 9.1e-01 SORT1 SYPL2 TMEM258
Breast Cancer 0.95 1 0 0.0 0.00 1.0e+00 SPTY2D1
Ovarian Cancer 1.30 1 0 0.0 0.00 1.0e+00 CACFD1
Body Mass Index (BMI) (2010) 1.90 2 1 3.0 -1.00 1.5e-03 POC5 POLK
Coronary Artery Disease (CAD) 3.64 6 2 6.1 0.82 4.5e-02 ALDH2 EPOR HNF1A PSRC1 SMARCA4 ZNF259
Crohns Disease (2012) 1.15 4 0 0.0 -0.64 3.6e-01 DOCK7 RASIP1 TIMD4 TMEM258
Fasting Glucose 2.02 2 1 3.0 0.00 1.0e+00 GCNT4 TMEM258
HDL Cholesterol 11.97 8 6 18.2 -0.54 1.6e-01 APOB C6orf106 HS1BP3 NLRC5 PSRC1 TMEM258 TOMM40 ZNF259
Primary Biliary Cirrhosis 1.73 2 1 3.0 0.00 1.0e+00 ALDH2 CARM1
Triglycerides 11.82 13 10 30.3 0.59 3.4e-02 APOB ATP13A1 DOCK7 HPR HS1BP3 LPIN3 NLRC5 PAFAH1B2 PCSK7 SDCBP TIMD4 TMEM258 ZNF259
Blood Eosinophil Count 2.47 15 8 24.2 -0.24 3.2e-01 ALDH2 BCAM CACFD1 CARM1 DCPS EPOR HNF1A LPIN3 OASL PAFAH1B2 PVRL2 SMARCA4 TMEM258 TOMM40 ZNF259
Blood Platelet Count 3.12 35 32 97.0 -0.13 4.1e-01 ALDH2 ANKDD1B ANKRD31 AP1M2 ATP13A1 BLOC1S3 C6orf106 CACFD1 COL4A3BP CTB-179K24.3 DDX56 DOCK7 EVI5 GCNT4 GSTM1 HNF1A HPR KLC3 LDLRAP1 MARC2 OASL PAFAH1B2 PCSK7 PLEC POC5 POLK PVR RASIP1 SMARCA4 TIMD4 TMEM258 TMEM50A TOMM40 ZNF259 ZNF285
Blood Red Count 1.96 22 11 33.3 -0.22 3.0e-01 ALDH2 ATP13A1 C6orf106 CACFD1 DDX56 DHX38 EFCAB13 HNF1A HPR HS1BP3 KLC3 LPIN3 MKRN2 PCSK7 PLEC SDCBP SDF2 SORT1 SYPL2 TIMD4 TMEM258 ZHX3
Blood White Count 1.83 15 8 24.2 -0.57 9.3e-03 ALDH2 ATP13A1 CACFD1 CARM1 EVI5 GEMIN7 GSTM3 NYNRIN PAFAH1B2 PVR RP4-735C1.4 SMARCA4 STXBP3 TIMD4 TMEM258
Heel T-Score 0.98 14 6 18.2 -0.69 4.7e-03 ATP13A1 CACFD1 DOCK7 EVI5 LDLRAP1 MKRN2 PSRC1 SDF2 SORT1 SYPL2 TMEM258 TMEM50A USP24 ZHX3
BMI 3.35 14 11 33.3 -0.81 1.3e-05 AMIGO1 ANKDD1B ANKRD31 C6orf106 COL4A3BP DHODH EVI5 GCNT4 HPR POC5 POLK SDF2 SORT1 SYPL2
Height 1.45 26 20 60.6 -0.39 2.9e-02 ALDH2 AMIGO1 ATP13A1 C6orf106 CACFD1 CARM1 DCPS DHX38 EFCAB13 EPOR EVI5 FRK GPSM2 ILF3 MKRN2 NYNRIN PLEC POC5 PSRC1 RASIP1 SMARCA4 SPTY2D1 TMEM258 TMEM50A ZNF229 ZNF259
Waist Hip Ratio (WHR) 1.06 8 3 9.1 0.51 1.9e-01 ATP13A1 C6orf106 LPIN3 MKRN2 PLEC RASIP1 SMARCA4 ZHX3
Systolic Blood Pressure 1.22 8 3 9.1 0.38 3.2e-01 ALDH2 DYNC2LI1 EPOR PAFAH1B2 PCSK7 RASIP1 SMARCA4 TOMM40
Allergy or Eczema 1.04 4 1 3.0 0.86 1.4e-01 ALDH2 C6orf106 HNF1A PVRL2
Cardiovascular Disease 4.85 30 19 57.6 0.88 2.1e-12 ALDH2 AP1M2 APOB BCAM CARM1 COL4A3BP DHODH DHX38 DOCK7 EFCAB13 EPOR FRK HNF1A HPR MKRN2 NPC1L1 OASL PAFAH1B2 PCSK7 POC5 POLK PSRC1 PVRL2 RASIP1 SDCBP SMARCA4 TIMD4 TOMM40 ZNF259 ZNF285
Hypothyroidism (self reported) 2.26 4 3 9.1 0.26 7.4e-01 ALDH2 DDX56 RASIP1 TMEM258
Respiratory disease 1.45 2 1 3.0 0.00 1.0e+00 BLOC1S3 TMEM258
Type 2 Diabetes (T2D) 1.56 4 0 0.0 -0.99 1.0e-02 ANKDD1B ATP13A1 GCNT4 POC5
Lung FEV1/FVC ratio 1.05 6 4 12.1 0.01 9.9e-01 C6orf106 DCPS EVI5 FRK PSRC1 RASIP1
Lung FVC 0.65 2 1 3.0 0.00 1.0e+00 C6orf106 CACFD1
Neuroticism 1.10 2 0 0.0 0.00 1.0e+00 AMIGO1 CTB-179K24.3
Chronotype (morning person) 1.40 5 1 3.0 0.18 7.7e-01 ALDH2 AMIGO1 DHX38 RP5-1160K1.3 ZNF285
Hair Pigment 0.20 11 3 9.1 0.20 5.2e-01 ALDH2 C6orf106 CARM1 DHX38 EFCAB13 EPOR HS1BP3 MKRN2 SDCBP SMARCA4 TMEM258
Tanning 0.18 4 0 0.0 -0.31 6.9e-01 ALDH2 DHX38 EPOR PLEC
Hand grip strength (left) 0.67 2 0 0.0 0.00 1.0e+00 C6orf106 DHX38
Number of treatments/medications taken 1.84 3 1 3.0 0.00 1.0e+00 ALDH2 PSRC1 TMEM258
Average weekly spirits intake 1.08 1 0 0.0 0.00 1.0e+00 RASIP1
Sensitivity / hurt feelings 1.02 2 0 0.0 0.00 1.0e+00 AMIGO1 SPTY2D1
Relative age of first facial hair 1.12 2 1 3.0 0.00 1.0e+00 C6orf106 EHBP1
Systolic blood pressure, automated reading 0.91 3 1 3.0 0.00 1.0e+00 ALDH2 RASIP1 SMARCA4
Angina 2.26 2 1 3.0 0.00 1.0e+00 C19orf80 PSRC1
Diabetes (father) 1.67 1 0 0.0 0.00 1.0e+00 POLK
Diabetes (mother) 1.56 1 0 0.0 0.00 1.0e+00 ATP13A1
Impedance of leg (right) 1.96 15 8 24.2 -0.83 3.5e-06 AMIGO1 ANKDD1B ANKRD31 ATP13A1 C6orf106 COL4A3BP EVI5 GCNT4 POC5 POLK SDCBP SORT1 SYPL2 TMEM167B TMEM50A
Leg fat-free mass (left) 2.91 14 9 27.3 0.79 3.8e-05 ALDH2 ANKDD1B ANKRD31 ATP13A1 C6orf106 COL4A3BP EPOR GCNT4 POC5 POLK SMARCA4 SORT1 SPTY2D1 SYPL2
Trunk fat percentage 2.12 11 7 21.2 0.76 6.0e-04 ANKDD1B ANKRD31 BCAM C6orf106 COL4A3BP FRK GCNT4 GSTM1 HPR POC5 POLK
Hand grip strength (right) 0.61 2 0 0.0 0.00 1.0e+00 C6orf106 DHX38
Average weekly fortified wine intake 0.93 1 0 0.0 0.00 1.0e+00 PLEC
Fed-up feelings 0.87 1 0 0.0 0.00 1.0e+00 ALDH2
Taking other prescription medications 1.07 1 0 0.0 0.00 1.0e+00 ALDH2
Age when periods started (menarche) 1.14 2 0 0.0 0.00 1.0e+00 HNF1A RASIP1
Heel bone mineral density (BMD) T-score, automated (left) 0.91 1 0 0.0 0.00 1.0e+00 TMEM258
High blood pressure 1.34 3 1 3.0 0.00 1.0e+00 ALDH2 NPC1L1 RASIP1
Hayfever, allergic rhinitis or eczema 1.13 2 0 0.0 0.00 1.0e+00 C6orf106 PVRL2
Medication: Atenolol 1.71 1 0 0.0 0.00 1.0e+00 ALDH2
Medication: Levothyroxine sodium 2.06 2 2 6.1 0.00 1.0e+00 ALDH2 TMEM258
Sitting height 1.22 15 6 18.2 0.36 1.6e-01 AMIGO1 ATP13A1 C6orf106 CACFD1 EFCAB13 EVI5 FRK HPR PLEC POC5 POLK RASIP1 SMARCA4 SPTY2D1 TMEM258
Body mass index (BMI) 3.01 10 8 24.2 0.84 9.7e-05 ANKDD1B ANKRD31 C6orf106 COL4A3BP EVI5 GCNT4 GSTM1 HPR POC5 POLK
Impedance of leg (left) 2.03 13 8 24.2 -0.86 2.9e-06 AMIGO1 ANKDD1B ATP13A1 C6orf106 COL4A3BP EVI5 GCNT4 POC5 POLK SORT1 SYPL2 TMEM167B TMEM50A
Leg predicted mass (left) 2.90 14 8 24.2 0.79 3.6e-05 ALDH2 ANKDD1B ANKRD31 ATP13A1 C6orf106 COL4A3BP EPOR GCNT4 POC5 POLK SMARCA4 SORT1 SPTY2D1 SYPL2
Trunk fat mass 2.77 11 8 24.2 0.76 6.1e-04 ANKDD1B ANKRD31 BCAM C6orf106 COL4A3BP FRK GCNT4 GSTM1 HPR POC5 POLK
Waist circumference 3.06 9 7 21.2 0.86 7.1e-05 ANKDD1B ANKRD31 C6orf106 COL4A3BP EVI5 GCNT4 HPR POC5 POLK
Past tobacco smoking 0.82 1 1 3.0 0.00 1.0e+00 ALDH2
Forced vital capacity (FVC) 0.95 3 2 6.1 0.89 1.1e-01 C6orf106 CACFD1 SMARCA4
Heel bone mineral density (BMD) T-score, automated (right) 1.01 2 0 0.0 0.00 1.0e+00 LDLRAP1 TMEM258
Qualifications: None of the above 1.07 2 0 0.0 0.00 1.0e+00 SORT1 SYPL2
Mouth/teeth dental problems 1.07 3 0 0.0 0.00 1.0e+00 DOCK7 RASIP1 SDF2
Heart attack 2.02 2 1 3.0 0.00 1.0e+00 C19orf80 PSRC1
Allergy 1.21 4 0 0.0 0.58 4.2e-01 BLOC1S3 C6orf106 PVRL2 TMEM258
Diabetes (self-reported) 1.75 4 0 0.0 0.99 1.0e-03 ATP13A1 GCNT4 POC5 POLK
Medication: Simvastatin 11.27 29 15 45.5 -0.97 2.5e-21 APOB ATP13A1 BCAM C19orf80 CARM1 CEACAM19 COL4A3BP DHODH DHX38 DOCK7 EPOR GPSM2 GSTM1 HPR LDLR LPIN3 NLRC5 NPC1L1 PAFAH1B2 PLEC POLK PSRC1 PVRL2 RASIP1 SMARCA4 TIMD4 TMEM258 TOMM40 ZNF259
Fluid intelligence score 1.44 3 0 0.0 -0.32 6.8e-01 SORT1 SYPL2 TMEM258
Weight 3.37 13 8 24.2 0.73 6.0e-04 ALDH2 ANKDD1B ANKRD31 C6orf106 COL4A3BP EPOR GCNT4 GSTM1 HPR POC5 POLK RASIP1 SMARCA4
Impedance of arm (right) 1.89 16 7 21.2 -0.73 1.0e-04 AMIGO1 ANKDD1B ANKRD31 C6orf106 COL4A3BP EFCAB13 EVI5 FRK GCNT4 POC5 POLK SDCBP SDF2 SORT1 SYPL2 TMEM167B
Arm fat percentage (right) 2.28 9 8 24.2 0.79 7.8e-04 ANKDD1B ANKRD31 C6orf106 COL4A3BP GCNT4 GSTM1 HPR POC5 POLK
Trunk fat-free mass 2.58 16 12 36.4 0.76 1.8e-05 ALDH2 ANKDD1B ANKRD31 C6orf106 COL4A3BP EPOR GCNT4 PLEC POC5 POLK PSRC1 RASIP1 SMARCA4 SORT1 SPTY2D1 SYPL2
Hip circumference 3.29 12 9 27.3 0.73 9.6e-04 ALDH2 ANKDD1B ANKRD31 C6orf106 COL4A3BP GCNT4 GSTM1 HPR POC5 POLK RASIP1 SMARCA4
Alcohol intake versus 10 years previously 1.60 2 0 0.0 0.00 1.0e+00 AMIGO1 RASIP1
Father's age at death 1.50 1 0 0.0 0.00 1.0e+00 PSRC1
Frequency of tiredness / lethargy in last 2 weeks 0.96 1 0 0.0 0.00 1.0e+00 ALDH2
Number of live births 1.49 1 0 0.0 0.00 1.0e+00 TMEM258
Forced expiratory volume in 1-second (FEV1) 1.08 5 2 6.1 0.90 6.0e-03 C6orf106 CACFD1 DHX38 EPOR SMARCA4
Pulse rate 1.68 2 1 3.0 0.00 1.0e+00 POC5 TMEM258
Noisy workplace 1.32 2 0 0.0 0.00 1.0e+00 RP5-1160K1.3 SYPL2
Qualifications: A levels/AS levels or equivalent 0.70 1 0 0.0 0.00 1.0e+00 GEMIN7
Serious illness, injury or assault of a close relative in last 2 years 1.21 1 0 0.0 0.00 1.0e+00 RASIP1
Mouth/teeth dental problems: Dentures 0.97 1 1 3.0 0.00 1.0e+00 RASIP1
Asthma 1.59 4 1 3.0 0.47 4.3e-01 BLOC1S3 CARM1 SMARCA4 TMEM258
Medication: Ibuprofen (e.g. Nurofen) 1.23 1 0 0.0 0.00 1.0e+00 RP5-1160K1.3
Medication: Cholesterol lowering 12.64 31 18 54.5 -0.97 7.2e-21 APOB ATP13A1 BCAM C19orf80 CARM1 COL4A3BP DHODH DHX38 DOCK7 DYNC2LI1 EPOR GPSM2 GSTM1 GSTM3 HNF1A HPR LDLR LPIN3 NPC1L1 PAFAH1B2 PLEC POLK PSRC1 PVRL2 RASIP1 RP4-735C1.4 RP5-1160K1.3 SMARCA4 TIMD4 TOMM40 ZNF259
Forced expiratory volume in 1-second (FEV1), Best measure 1.13 4 2 6.1 0.92 1.0e-02 C6orf106 CACFD1 EPOR SMARCA4
Impedance of arm (left) 1.88 15 7 21.2 -0.66 1.2e-03 ALDH2 ANKDD1B ANKRD31 C6orf106 COL4A3BP EFCAB13 EVI5 FRK GCNT4 POC5 POLK SDCBP SDF2 SORT1 SYPL2
Arm fat mass (right) 3.11 9 8 24.2 0.81 4.7e-04 ANKDD1B ANKRD31 C6orf106 COL4A3BP GCNT4 GSTM1 HPR POC5 POLK
Trunk predicted mass 2.59 16 12 36.4 0.76 1.8e-05 ALDH2 ANKDD1B ANKRD31 C6orf106 COL4A3BP EPOR GCNT4 PLEC POC5 POLK PSRC1 RASIP1 SMARCA4 SORT1 SPTY2D1 SYPL2
Standing height 1.52 20 13 39.4 0.45 3.2e-02 ALDH2 ATP13A1 C6orf106 CACFD1 CARM1 DCPS DHX38 EFCAB13 EPOR EVI5 FRK MKRN2 NYNRIN PLEC POC5 PSRC1 RASIP1 SMARCA4 SPTY2D1 TMEM258
Hair/balding pattern: Pattern 4 0.71 1 1 3.0 0.00 1.0e+00 TMEM258
Birth weight of first child 1.56 2 1 3.0 0.00 1.0e+00 ALDH2 ATP13A1
Peak expiratory flow (PEF) 1.25 3 1 3.0 1.00 1.4e-03 C6orf106 CACFD1 RASIP1
Mouth/teeth dental problems: Bleeding gums 1.26 1 0 0.0 0.00 1.0e+00 SDF2
Blood clot in the leg (DVT) 1.88 1 1 3.0 0.00 1.0e+00 CACFD1
Headache pain in last month 1.53 2 0 0.0 0.00 1.0e+00 ALDH2 POC5
Medication for cholesterol, blood pressure or diabetes 4.72 12 5 15.2 0.93 1.6e-06 APOB C19orf80 DHX38 EPOR HPR NPC1L1 PAFAH1B2 PSRC1 RASIP1 SMARCA4 TOMM40 ZNF259
Hypothyroidism/myxoedema (self-reported) 2.10 2 2 6.1 0.00 1.0e+00 ALDH2 TMEM258
Birth weight 1.34 2 1 3.0 0.00 1.0e+00 ALDH2 RASIP1
Chronic bronchitis/emphysema (mother) 1.08 1 0 0.0 0.00 1.0e+00 BCAM
Forced vital capacity (FVC), Best measure 1.02 5 2 6.1 0.92 9.5e-03 C6orf106 CACFD1 CARM1 EPOR SMARCA4
Body fat percentage 2.30 10 8 24.2 0.77 7.8e-04 ANKDD1B ANKRD31 BCAM C6orf106 COL4A3BP GCNT4 GSTM1 HPR POC5 POLK
Leg fat percentage (right) 2.27 8 7 21.2 0.90 2.7e-05 ANKDD1B ANKRD31 C6orf106 COL4A3BP GCNT4 GSTM1 POC5 POLK
Arm fat-free mass (right) 2.98 16 10 30.3 0.75 2.1e-05 ALDH2 ANKDD1B ANKRD31 C6orf106 COL4A3BP EPOR GCNT4 PLEC POC5 POLK PSRC1 RASIP1 SMARCA4 SORT1 SPTY2D1 SYPL2
Comparative body size at age 10 1.51 7 2 6.1 0.99 3.0e-08 ANKDD1B GCNT4 POC5 POLK RASIP1 SORT1 SYPL2
Worry too long after embarrassment 1.22 1 0 0.0 0.00 1.0e+00 POC5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.19 1 0 0.0 0.00 1.0e+00 TMEM258
Wheeze or whistling in the chest in last year 1.25 1 0 0.0 0.00 1.0e+00 TMEM258
Health satisfaction 0.90 1 0 0.0 0.00 1.0e+00 GPSM2
Qualifications: College or University degree 1.18 6 3 9.1 0.28 5.4e-01 AMIGO1 CACFD1 GEMIN7 KLC3 SORT1 SYPL2
Medication for pain relief, constipation, heartburn 1.00 1 0 0.0 0.00 1.0e+00 EFCAB13
Medication: Blood pressure 1.37 2 1 3.0 0.00 1.0e+00 ALDH2 NPC1L1
Angina (self-reported) 2.33 2 1 3.0 0.00 1.0e+00 C19orf80 PSRC1
Migraine (self-reported) 1.67 1 0 0.0 0.00 1.0e+00 POC5
Medication: Ibuprofen 1.06 1 0 0.0 0.00 1.0e+00 RP5-1160K1.3
Medication: Allopurinol 1.30 1 0 0.0 0.00 1.0e+00 ALDH2
Mean time to correctly identify matches 1.05 1 1 3.0 0.00 1.0e+00 ALDH2
Heart disease (mother) 1.80 1 0 0.0 0.00 1.0e+00 ALDH2
Whole body fat mass 3.00 9 8 24.2 0.80 6.1e-04 ANKDD1B ANKRD31 C6orf106 COL4A3BP GCNT4 GSTM1 HPR POC5 POLK
Leg fat mass (right) 3.29 10 7 21.2 0.76 9.6e-04 ALDH2 ANKDD1B ANKRD31 C6orf106 COL4A3BP GCNT4 GSTM1 HPR POC5 POLK
Arm predicted mass (right) 2.95 16 9 27.3 0.75 3.8e-05 ALDH2 ANKDD1B ANKRD31 C6orf106 COL4A3BP EPOR GCNT4 PLEC POC5 POLK PSRC1 RASIP1 SMARCA4 SORT1 SPTY2D1 SYPL2
Pulse rate, automated reading 1.61 3 2 6.1 0.00 1.0e+00 C6orf106 POC5 TMEM258
Alcohol intake frequency. 0.84 1 1 3.0 0.00 1.0e+00 RASIP1
Comparative height size at age 10 1.46 15 5 15.2 0.32 2.4e-01 ALDH2 ANKDD1B ATP13A1 C6orf106 DHX38 EVI5 HNF1A MKRN2 NYNRIN PLEC POC5 POLK PSRC1 RASIP1 SPTY2D1
Overall health rating 0.86 1 1 3.0 0.00 1.0e+00 C6orf106
Medication: Aspirin 2.50 1 1 3.0 0.00 1.0e+00 PSRC1
Hypertension (Self-reported) 1.29 3 2 6.1 0.00 1.0e+00 ALDH2 NPC1L1 RASIP1
Illnesses of father: Heart disease 2.69 4 1 3.0 -0.97 3.0e-02 EPOR NPC1L1 PSRC1 SMARCA4
Smoking status: Previous 1.13 1 1 3.0 0.00 1.0e+00 ALDH2
Forced expiratory volume in 1-second (FEV1), predicted 1.61 2 1 3.0 0.00 1.0e+00 C6orf106 PLEC
Whole body fat-free mass 2.79 17 12 36.4 0.72 4.7e-05 ALDH2 ANKDD1B ANKRD31 ATP13A1 C6orf106 COL4A3BP EPOR GCNT4 PLEC POC5 POLK PSRC1 RASIP1 SMARCA4 SORT1 SPTY2D1 SYPL2
Leg fat-free mass (right) 2.80 14 8 24.2 0.78 4.2e-05 ALDH2 ANKDD1B ANKRD31 ATP13A1 C6orf106 COL4A3BP EPOR GCNT4 POC5 POLK SMARCA4 SORT1 SPTY2D1 SYPL2
Arm fat percentage (left) 2.29 9 8 24.2 0.79 7.5e-04 ANKDD1B ANKRD31 C6orf106 COL4A3BP GCNT4 GSTM1 HPR POC5 POLK
Mood swings 1.09 1 0 0.0 0.00 1.0e+00 AMIGO1
Diabetes diagnosed by doctor 1.66 3 0 0.0 0.00 1.0e+00 ATP13A1 GCNT4 POC5
Medication for cholesterol 3.18 7 1 3.0 0.79 3.6e-02 ALDH2 DOCK7 GPSM2 LDLR PAFAH1B2 PSRC1 RASIP1
Back pain experienced in last month 1.26 2 0 0.0 0.00 1.0e+00 APOB C6orf106
Asthma (self-reported) 1.51 4 1 3.0 0.31 6.9e-01 BLOC1S3 CARM1 SMARCA4 TMEM258
Medication: Aspirin 2.70 2 1 3.0 0.00 1.0e+00 EPOR PSRC1
Whole body water mass 2.78 17 11 33.3 0.72 5.1e-05 ALDH2 ANKDD1B ANKRD31 ATP13A1 C6orf106 COL4A3BP EPOR GCNT4 PLEC POC5 POLK PSRC1 RASIP1 SMARCA4 SORT1 SPTY2D1 SYPL2
Leg predicted mass (right) 2.80 14 8 24.2 0.79 3.9e-05 ALDH2 ANKDD1B ANKRD31 ATP13A1 C6orf106 COL4A3BP EPOR GCNT4 POC5 POLK SMARCA4 SORT1 SPTY2D1 SYPL2
Arm fat mass (left) 3.04 9 7 21.2 0.80 5.3e-04 ANKDD1B ANKRD31 C6orf106 COL4A3BP GCNT4 GSTM1 HPR POC5 POLK
Number of self-reported non-cancer illnesses 1.87 2 0 0.0 0.00 1.0e+00 ALDH2 RASIP1
Average weekly champagne plus white wine intake 1.12 1 1 3.0 0.00 1.0e+00 TMEM258
Medication: Blood pressure 1.29 2 1 3.0 0.00 1.0e+00 ALDH2 RASIP1
Supplements: Fish oil (including cod liver oil) 1.00 1 0 0.0 0.00 1.0e+00 TMEM258
High cholesterol (Self-reported) 24.27 55 38 115.2 -0.97 6.8e-43 AMIGO1 ANKDD1B ANKRD31 AP1M2 APOB ATP13A1 BCAM C19orf80 CARM1 CEACAM19 COL4A3BP DDX56 DHODH DHX38 DOCK7 EFCAB13 EPOR FRK GCNT4 GPSM2 GSTM1 GSTM3 HNF1A HPR HS1BP3 ILF3 LDLR LDLRAP1 LPIN3 MKRN2 N4BP2L1 NPC1L1 NYNRIN OASL PAFAH1B2 PCSK7 PLEC POC5 POLK PSRC1 PVR PVRL2 RASIP1 RP4-735C1.4 RP5-1160K1.3 SDCBP SMARCA4 TIMD4 TMEM258 TOMM40 USP24 ZHX3 ZNF112 ZNF259 ZNF285
Medication: Bendroflumethiazide 0.95 1 0 0.0 0.00 1.0e+00 RASIP1
Medication: Atorvastatin 9.85 21 11 33.3 -0.95 9.1e-13 ANKDD1B APOB ATP13A1 BCAM C19orf80 COL4A3BP DOCK7 EFCAB13 EPOR GPSM2 HPR LPIN3 PAFAH1B2 POLK PSRC1 PVRL2 RASIP1 SMARCA4 TOMM40 ZNF259 ZNF285
Ever smoked 0.96 1 0 0.0 0.00 1.0e+00 ALDH2
Basal metabolic rate 3.02 17 10 30.3 0.71 9.7e-05 ALDH2 ANKDD1B ANKRD31 ATP13A1 C6orf106 COL4A3BP EPOR GCNT4 PLEC POC5 POLK PSRC1 RASIP1 SMARCA4 SORT1 SPTY2D1 SYPL2
Leg fat percentage (left) 2.33 10 7 21.2 0.88 1.6e-05 ANKDD1B ANKRD31 BCAM C6orf106 COL4A3BP GCNT4 GSTM1 POC5 POLK RP5-1160K1.3
Arm fat-free mass (left) 3.00 16 10 30.3 0.74 4.7e-05 ALDH2 ANKDD1B ANKRD31 C6orf106 COL4A3BP EPOR GCNT4 PLEC POC5 POLK PSRC1 RASIP1 SMARCA4 SORT1 SPTY2D1 SYPL2
Number of operations (self-reported) 0.58 1 0 0.0 0.00 1.0e+00 C6orf106
Irritability 1.06 3 0 0.0 0.00 1.0e+00 ATP13A1 EFCAB13 TMEM258
Diastolic blood pressure, automated reading 1.14 2 1 3.0 0.00 1.0e+00 ALDH2 C19orf80
Myopia 1.45 2 0 0.0 0.00 1.0e+00 C6orf106 TMEM258
Vascular/heart problems diagnosed by doctor 1.45 4 1 3.0 -0.46 5.4e-01 ALDH2 EVI5 NPC1L1 RASIP1
Cholesterol lowering medication 12.76 32 17 51.5 -0.96 2.7e-21 AP1M2 APOB BCAM C19orf80 CARM1 COL4A3BP DOCK7 EPOR GCNT4 GPSM2 HNF1A HPR ILF3 LDLR LPIN3 N4BP2L1 NPC1L1 OASL PAFAH1B2 PCSK7 POLK PSRC1 PVRL2 RASIP1 SMARCA4 TIMD4 TMEM167B TOMM40 ZHX3 ZNF112 ZNF259 ZNF285
Pain experienced in last month 1.30 2 0 0.0 0.00 1.0e+00 ALDH2 DHX38
Heart attack/myocardial infarction (self-reported) 1.97 1 1 3.0 0.00 1.0e+00 PSRC1
Deep venous thrombosis (DVT) (self-reported) 1.71 1 1 3.0 0.00 1.0e+00 CACFD1
Heart disease (siblings) 2.17 2 0 0.0 0.00 1.0e+00 SDF2 SMARCA4
Impedance of whole body 2.06 14 10 30.3 -0.85 1.6e-06 AMIGO1 ANKDD1B ANKRD31 C6orf106 COL4A3BP EVI5 FRK GCNT4 POC5 POLK SDCBP SORT1 SYPL2 TMEM167B
Leg fat mass (left) 3.30 10 7 21.2 0.77 8.7e-04 ALDH2 ANKDD1B ANKRD31 C6orf106 COL4A3BP GCNT4 GSTM1 HPR POC5 POLK
Arm predicted mass (left) 3.04 17 11 33.3 0.74 3.7e-05 ALDH2 ANKDD1B ANKRD31 C6orf106 COL4A3BP EPOR GCNT4 PLEC POC5 POLK PSRC1 RASIP1 SDF2 SMARCA4 SORT1 SPTY2D1 SYPL2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 8 0.2358 1.55
GTEx Adipose Visceral Omentum 5 0.2525 1.50
GTEx Adrenal Gland 7 0.4919 1.56
GTEx Artery Aorta 7 0.2421 1.55
GTEx Artery Coronary 1 0.0865 1.45
GTEx Artery Tibial 14 0.3843 1.62
GTEx Brain Caudate basal ganglia 1 0.1115 1.40
GTEx Brain Cerebellar Hemisphere 4 0.2755 1.56
GTEx Brain Cerebellum 4 0.2073 1.53
GTEx Brain Cortex 2 0.1986 1.58
GTEx Brain Frontal Cortex BA9 1 0.1112 1.52
GTEx Brain Hippocampus 2 0.3922 1.67
GTEx Brain Hypothalamus 3 0.5236 1.49
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.44
GTEx Brain Putamen basal ganglia 1 0.1647 1.49
GTEx Breast Mammary Tissue 2 0.1045 1.45
GTEx Breast Mammary Tissue (Male) 4 0.3448 1.56
GTEx Breast Mammary Tissue (Female) 3 0.1901 1.47
GTEx Cells EBV-transformed lymphocytes 3 0.2168 1.46
GTEx Cells Transformed fibroblasts 23 0.5626 1.60
GTEx Colon Sigmoid 3 0.2102 1.65
GTEx Colon Transverse 6 0.3003 1.61
GTEx Esophagus Gastroesophageal Junction 1 0.0714 1.47
GTEx Esophagus Mucosa 13 0.4022 1.93
GTEx Esophagus Muscularis 10 0.3182 1.49
GTEx Heart Atrial Appendage 4 0.2594 1.62
GTEx Heart Left Ventricle 3 0.2026 1.44
GTEx Liver 5 0.7184 3.60
GTEx Lung 4 0.1432 1.43
GTEx Muscle Skeletal 9 0.3201 1.80
GTEx Nerve Tibial 11 0.2613 1.53
GTEx Ovary 5 0.5643 1.60
GTEx Pancreas 6 0.3764 1.67
GTEx Pituitary 5 0.4554 1.73
GTEx Prostate 2 0.2457 1.53
GTEx Skin Not Sun Exposed Suprapubic 5 0.2082 1.58
GTEx Skin Sun Exposed Lower leg 15 0.4249 1.75
GTEx Small Intestine Terminal Ileum 2 0.4425 1.64
GTEx Spleen 7 0.5069 1.75
GTEx Stomach 6 0.4228 1.76
GTEx Testis 9 0.2925 1.51
GTEx Thyroid 10 0.2579 1.55
GTEx Uterus 3 0.5405 1.63
GTEx Vagina 0 0.0000 1.48
GTEx Whole Blood 8 0.4147 2.07
METSIM Adipose 16 0.3536 1.55
NTR Blood 11 0.4612 1.65
ROSMAP Brain Pre-frontal Cortex 19 0.4432 1.90
YFS Blood 9 0.1972 1.66
CommonMind Brain Pre-frontal Cortex 24 0.4545 1.71
TCGA Breast Tumor 2 0.2639 1.54
TCGA Breast Normal 16 0.3875 1.52
TCGA Ovarian Tumor 7 0.2426 1.56
TCGA Prostate Tumor 9 0.2655 1.48