Hub : Traits :

Qualifications: None of the above

579 significantly associated models · 133 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 43073464 45157738 12 3 2.0e-13 2.2e-15 3.1e-01 98 MED8 RP11-7O11.3 ST3GAL3
2 1 71163715 73435171 1 1 4.8e-10 4.2e-09 4.0e-04 64 NEGR1
3 1 92957826 94426916 1 1 3.3e-08 2.9e-07 8.6e-01 100 CCDC18
4 1 109316076 110716511 1 1 6.3e-08 7.4e-07 4.5e-02 84 SYPL2
5 2 43899918 45698128 1 1 3.6e-09 8.4e-10 4.7e-02 90 CAMKMT
6 2 100193898 101731705 2 1 6.8e-09 6.5e-09 1.4e-01 93 CHST10
7 2 106725928 108199394 1 1 1.2e-07 1.9e-07 1.0e+00 100 ST6GAL2
8 3 16154636 17814553 1 1 2.2e-08 2.7e-09 1.8e-02 84 PLCL2
9 3 48268509 51009435 26 2 2.2e-15 2.1e-13 4.4e-01 99 GPX1 MST1R
10 3 52047421 53860103 3 1 1.7e-07 3.5e-08 8.0e-02 90 NEK4
11 3 107181540 108633112 1 1 1.0e-07 2.0e-06 1.4e-01 90 IFT57
12 4 2233366 3740612 3 1 1.4e-07 5.6e-08 1.0e-05 34 GRK4
13 4 105598022 107092169 1 1 3.0e-09 3.2e-09 1.3e-02 82 PPA2
14 5 26181001 27729100 1 1 2.2e-07 6.9e-09 2.3e-04 60 CDH9
15 5 59193824 61156570 6 2 1.9e-17 3.2e-17 7.0e-01 100 ELOVL7
16 5 87006055 88875673 2 2 4.5e-10 7.9e-17 2.0e-08 55 CTC-498M16.2 MEF2C
17 5 176132977 177591495 2 1 5.9e-09 1.0e-08 1.0e+00 100 DBN1
18 6 87530372 88997402 1 1 2.8e-08 2.4e-08 1.0e+00 100 RARS2
19 6 108183628 109704062 1 1 3.3e-07 2.6e-08 1.2e-02 80 FOXO3
20 7 23913624 25432157 1 1 3.5e-08 2.2e-08 1.0e+00 100 MPP6
21 8 30012514 31433801 1 1 1.8e-07 9.3e-08 1.0e-01 91 TEX15
22 8 142629143 144515639 2 2 2.2e-10 6.9e-11 1.4e-04 66 THEM6 TSNARE1
23 9 111008699 112472083 1 1 2.5e-07 2.2e-06 3.3e-02 80 CTNNAL1
24 10 10349662 12076043 1 1 1.6e-08 7.7e-08 1.0e-02 77 CELF2
25 10 64195778 65911294 3 2 2.3e-11 1.6e-15 1.1e-05 70 JMJD1C-AS1 NRBF2
26 10 102853189 104242886 1 1 2.6e-08 1.0e-08 1.5e-03 69 NPM3
27 10 133048749 134482926 2 2 7.8e-10 2.2e-12 8.7e-01 100 BNIP3 PPP2R2D
28 11 94805896 96276010 4 1 1.9e-13 2.9e-13 2.2e-01 97 AP001877.1
29 12 49556303 50927881 1 1 4.7e-08 4.9e-05 3.0e-02 71 BCDIN3D
30 12 55677395 57125879 5 1 5.4e-11 1.9e-10 1.0e+00 100 SUOX
31 12 120215864 121627458 1 1 4.2e-07 3.4e-05 9.2e-02 84 DYNLL1
32 12 122258047 124591385 12 2 1.8e-13 6.2e-12 4.0e-01 98 C12orf65 RSRC2
33 13 31078511 32595740 1 1 2.2e-07 1.7e-06 1.8e-01 92 B3GALTL
34 14 73853137 75366447 1 1 5.6e-08 3.0e-06 8.3e-04 49 LIN52
35 14 77477664 78879614 1 1 1.9e-09 5.9e-06 1.1e-03 48 C14orf156
36 16 86671 1488646 2 1 1.4e-07 1.0e-06 7.4e-01 100 WDR24
37 16 27655848 29595483 23 1 3.6e-10 8.8e-10 5.3e-01 99 SULT1A1
38 16 52828325 54235440 1 1 1.9e-07 6.7e-09 9.5e-03 80 AKTIP
39 17 34815551 35675511 1 1 1.5e-07 1.3e-06 5.4e-04 49 CTB-75G16.3
40 19 45064435 46506809 1 1 4.8e-08 1.5e-11 6.5e-06 55 MARK4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.95 4 2 6.1 -0.50 5.0e-01 GPX1 MST1R NEK4 SULT1A1
Irritable Bowel Disease (IBD) 2.33 4 3 9.1 -0.61 3.9e-01 CCDC18 GPX1 MST1R SULT1A1
Ulcerative Colitis (UC) 2.22 3 2 6.1 0.00 1.0e+00 GPX1 MST1R SULT1A1
Major Depression (MDD) 2.66 2 1 3.0 0.00 1.0e+00 GPX1 NEGR1
Reaction Time 1.76 1 1 3.0 0.00 1.0e+00 FOXO3
Verbal and Numeric Reasoning (VNR) 7.60 20 13 39.4 0.98 3.3e-14 AKTIP CDH9 CHST10 CTB-75G16.3 DBN1 ELOVL7 FOXO3 GPX1 IFT57 JMJD1C-AS1 MST1R NEGR1 NPM3 PLCL2 PPA2 ST3GAL3 ST6GAL2 SULT1A1 SUOX TEX15
Breast Cancer 1.30 1 0 0.0 0.00 1.0e+00 GPX1
Prostate Cancer 1.40 2 0 0.0 0.00 1.0e+00 GPX1 PPA2
Age at First Birth 3.76 3 2 6.1 0.00 1.0e+00 CHST10 GPX1 MST1R
Body Mass Index (BMI) (2010) 3.18 3 2 6.1 0.00 1.0e+00 CTB-75G16.3 NEGR1 SULT1A1
Crohns Disease (2012) 2.00 4 2 6.1 0.48 5.2e-01 GPX1 MST1R NEK4 SULT1A1
HDL Cholesterol 1.71 2 0 0.0 0.00 1.0e+00 CCDC18 NRBF2
Primary Biliary Cirrhosis 1.14 1 0 0.0 0.00 1.0e+00 PLCL2
Schizophrenia 2.23 3 1 3.0 0.00 1.0e+00 C12orf65 ELOVL7 PLCL2
Triglycerides 1.81 1 1 3.0 0.00 1.0e+00 NRBF2
Ulcerative Colitis 1.82 2 1 3.0 0.00 1.0e+00 GPX1 MST1R
Blood Eosinophil Count 1.36 7 6 18.2 0.18 7.0e-01 C12orf65 CCDC18 MARK4 MST1R NEK4 PLCL2 SUOX
Blood Platelet Count 3.46 10 9 27.3 0.21 5.6e-01 C12orf65 CCDC18 DYNLL1 GRK4 JMJD1C-AS1 MARK4 MEF2C MPP6 NRBF2 WDR24
Blood Red Count 1.36 13 10 30.3 -0.24 4.2e-01 AP001877.1 CAMKMT CCDC18 CHST10 CTC-498M16.2 DYNLL1 LIN52 MED8 MEF2C NRBF2 PLCL2 SULT1A1 SUOX
Blood White Count 1.99 11 7 21.2 -0.57 6.5e-02 CTC-498M16.2 GPX1 GRK4 JMJD1C-AS1 MARK4 MED8 MPP6 MST1R NRBF2 PPA2 TEX15
Heel T-Score 0.81 3 2 6.1 0.00 1.0e+00 C12orf65 NEGR1 NEK4
BMI 4.56 18 16 48.5 -0.61 6.8e-03 CAMKMT CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 IFT57 MEF2C MST1R NEGR1 NEK4 NRBF2 RSRC2 SULT1A1 SUOX TEX15 THEM6
Height 1.79 20 14 42.4 0.74 1.8e-04 AKTIP AP001877.1 BCDIN3D C12orf65 CAMKMT CCDC18 CTNNAL1 ELOVL7 FOXO3 GPX1 JMJD1C-AS1 LIN52 MED8 MPP6 NEK4 NRBF2 PPA2 PPP2R2D RSRC2 WDR24
Waist Hip Ratio (WHR) 1.95 8 4 12.1 -0.50 2.0e-01 AKTIP C12orf65 CTNNAL1 ELOVL7 GPX1 NEK4 PLCL2 RSRC2
Systolic Blood Pressure 1.89 9 4 12.1 -0.59 9.7e-02 FOXO3 GPX1 MED8 MPP6 NEK4 PPP2R2D RSRC2 ST6GAL2 TSNARE1
Smoking Status 4.16 13 7 21.2 -0.97 8.6e-08 CELF2 DYNLL1 ELOVL7 GPX1 IFT57 MED8 MEF2C MST1R NEK4 PLCL2 RP11-7O11.3 SUOX WDR24
Allergy or Eczema 2.78 7 3 9.1 0.70 8.2e-02 C12orf65 CCDC18 CTB-75G16.3 NEGR1 PLCL2 SULT1A1 SUOX
Cardiovascular Disease 2.04 5 1 3.0 -0.32 6.0e-01 MED8 NEGR1 NRBF2 SULT1A1 TEX15
Hypothyroidism (self reported) 1.84 1 1 3.0 0.00 1.0e+00 SUOX
Respiratory disease 1.99 2 1 3.0 0.00 1.0e+00 MST1R SUOX
Type 2 Diabetes (T2D) 1.63 1 0 0.0 0.00 1.0e+00 AKTIP
Lung FEV1/FVC ratio 1.91 8 5 15.2 -0.02 9.5e-01 FOXO3 GPX1 JMJD1C-AS1 LIN52 NEGR1 NRBF2 PPA2 SUOX
Lung FVC 1.40 8 3 9.1 -0.44 2.8e-01 BCDIN3D C12orf65 FOXO3 GPX1 GRK4 JMJD1C-AS1 NRBF2 SUOX
Neuroticism 2.30 6 2 6.1 -0.61 2.0e-01 B3GALTL CTC-498M16.2 GPX1 MST1R PLCL2 TSNARE1
Chronotype (morning person) 2.38 4 1 3.0 -0.63 3.7e-01 CAMKMT DBN1 LIN52 SYPL2
Hair Pigment 0.15 4 2 6.1 -1.00 2.0e-03 C12orf65 FOXO3 JMJD1C-AS1 SUOX
Hand grip strength (left) 1.13 2 2 6.1 0.00 1.0e+00 NEK4 NPM3
Number of treatments/medications taken 3.22 6 3 9.1 0.75 8.5e-02 B3GALTL GPX1 MST1R NEGR1 PPP2R2D ST6GAL2
Sensitivity / hurt feelings 1.66 1 0 0.0 0.00 1.0e+00 PLCL2
Frequency of depressed mood in last 2 weeks 2.30 3 1 3.0 0.00 1.0e+00 CELF2 JMJD1C-AS1 PLCL2
Relative age of first facial hair 1.64 3 0 0.0 0.00 1.0e+00 FOXO3 MED8 NRBF2
Ever used hormone-replacement therapy (HRT) 1.75 1 0 0.0 0.00 1.0e+00 BCDIN3D
Systolic blood pressure, automated reading 2.27 6 3 9.1 0.54 2.7e-01 GPX1 MED8 MPP6 NEK4 PPA2 TSNARE1
Supplements: Zinc 1.63 1 1 3.0 0.00 1.0e+00 NRBF2
Medication: Co-codamol 1.99 2 0 0.0 0.00 1.0e+00 GPX1 MST1R
Pack years adult smoking proportion 3.19 4 1 3.0 0.37 6.3e-01 BNIP3 GPX1 GRK4 JMJD1C-AS1
Impedance of leg (right) 2.30 13 6 18.2 0.01 9.6e-01 AKTIP AP001877.1 CTNNAL1 ELOVL7 FOXO3 GPX1 MEF2C MST1R NEGR1 NEK4 PPA2 SULT1A1 SUOX
Leg fat-free mass (left) 2.90 16 10 30.3 -0.09 7.5e-01 AKTIP BCDIN3D C12orf65 CTB-75G16.3 CTC-498M16.2 ELOVL7 FOXO3 GPX1 IFT57 MST1R NEGR1 PPA2 RSRC2 SULT1A1 SUOX WDR24
Trunk fat percentage 3.10 12 7 21.2 0.51 8.9e-02 CHST10 CTB-75G16.3 FOXO3 GPX1 GRK4 MPP6 MST1R NEGR1 RSRC2 SULT1A1 TEX15 THEM6
Hand grip strength (right) 1.28 3 1 3.0 0.00 1.0e+00 NEK4 NPM3 SULT1A1
Townsend deprivation index at recruitment 2.77 1 0 0.0 0.00 1.0e+00 MARK4
Maternal smoking around birth 3.32 2 0 0.0 0.00 1.0e+00 CTB-75G16.3 MED8
Fed-up feelings 3.36 6 2 6.1 0.99 1.1e-04 B3GALTL GPX1 MST1R PLCL2 TEX15 THEM6
Frequency of unenthusiasm / disinterest in last 2 weeks 3.35 2 1 3.0 0.00 1.0e+00 GPX1 JMJD1C-AS1
Relative age voice broke 1.87 2 0 0.0 0.00 1.0e+00 FOXO3 NRBF2
Taking other prescription medications 2.83 3 2 6.1 0.00 1.0e+00 B3GALTL GPX1 MST1R
Age when periods started (menarche) 3.08 9 6 18.2 0.72 3.0e-02 CTNNAL1 FOXO3 GPX1 MED8 MST1R NEGR1 NRBF2 RP11-7O11.3 SUOX
Qualifications: CSEs or equivalent 2.69 3 0 0.0 0.00 1.0e+00 GPX1 JMJD1C-AS1 ST3GAL3
High blood pressure 2.18 8 0 0.0 0.43 2.9e-01 AKTIP MED8 NEGR1 NRBF2 RSRC2 SUOX TEX15 TSNARE1
Hayfever, allergic rhinitis or eczema 2.71 6 1 3.0 -0.66 1.5e-01 C12orf65 CCDC18 NEGR1 PLCL2 SULT1A1 SUOX
Multivitamins +/- minerals 2.33 1 0 0.0 0.00 1.0e+00 NRBF2
Medication: Levothyroxine sodium 1.38 1 1 3.0 0.00 1.0e+00 SUOX
Sitting height 2.01 11 7 21.2 -0.94 2.3e-05 AKTIP C12orf65 CAMKMT FOXO3 MED8 NEK4 PPA2 PPP2R2D RP11-7O11.3 RSRC2 WDR24
Body mass index (BMI) 4.58 19 12 36.4 0.69 1.2e-03 CAMKMT CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 IFT57 MEF2C MPP6 MST1R NEGR1 NEK4 NRBF2 RSRC2 SULT1A1 SUOX TEX15 THEM6
Impedance of leg (left) 2.32 12 7 21.2 0.04 9.0e-01 AKTIP AP001877.1 C12orf65 ELOVL7 GPX1 MEF2C MST1R NEGR1 NEK4 PPA2 SULT1A1 SUOX
Leg predicted mass (left) 2.91 16 10 30.3 -0.09 7.5e-01 AKTIP BCDIN3D C12orf65 CTB-75G16.3 CTC-498M16.2 ELOVL7 FOXO3 GPX1 IFT57 MST1R NEGR1 PPA2 RSRC2 SULT1A1 SUOX WDR24
Trunk fat mass 3.30 12 9 27.3 0.48 1.1e-01 CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 MST1R NEGR1 RSRC2 SULT1A1 TEX15 THEM6
Waist circumference 3.82 16 9 27.3 0.60 1.4e-02 CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 IFT57 MST1R NEGR1 NRBF2 RSRC2 ST6GAL2 SULT1A1 SUOX TEX15 THEM6
Past tobacco smoking 2.45 4 0 0.0 -1.00 4.6e-03 CELF2 RP11-7O11.3 SUOX WDR24
Alcohol usually taken with meals 4.90 5 1 3.0 -0.98 8.1e-04 CHST10 ELOVL7 MED8 NEGR1 NRBF2
Nervous feelings 2.17 5 0 0.0 0.63 2.6e-01 AP001877.1 B3GALTL CTC-498M16.2 PLCL2 TSNARE1
Frequency of tenseness / restlessness in last 2 weeks 2.39 3 2 6.1 0.00 1.0e+00 B3GALTL GPX1 JMJD1C-AS1
Had other major operations 1.81 1 0 0.0 0.00 1.0e+00 PPA2
Forced vital capacity (FVC) 1.56 6 2 6.1 -0.99 1.2e-04 BCDIN3D GPX1 GRK4 PPA2 PPP2R2D RSRC2
Mouth/teeth dental problems 1.96 1 0 0.0 0.00 1.0e+00 ELOVL7
Allergy 2.48 3 2 6.1 0.00 1.0e+00 C12orf65 NEGR1 SUOX
Pain all over the body in last month 2.37 1 0 0.0 0.00 1.0e+00 GPX1
Diabetes (self-reported) 1.90 2 0 0.0 0.00 1.0e+00 AKTIP ST6GAL2
Hayfever/allergic rhinitis (self-reported) 1.66 1 0 0.0 0.00 1.0e+00 SUOX
Fluid intelligence score 7.97 25 11 33.3 -0.99 2.4e-19 AKTIP BNIP3 C12orf65 CAMKMT CDH9 CELF2 CHST10 CTB-75G16.3 DBN1 FOXO3 GPX1 IFT57 JMJD1C-AS1 MED8 MST1R NEGR1 NPM3 PLCL2 PPA2 RP11-7O11.3 ST3GAL3 ST6GAL2 SULT1A1 SUOX TEX15
Illnesses of siblings 2.34 1 0 0.0 0.00 1.0e+00 ST3GAL3
Neuroticism score 2.34 5 2 6.1 0.97 5.1e-03 B3GALTL CELF2 GPX1 MST1R PLCL2
Weight 3.54 14 10 30.3 0.31 2.8e-01 AKTIP C12orf65 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 IFT57 MST1R NEGR1 RSRC2 SULT1A1 SUOX TEX15 THEM6
Impedance of arm (right) 3.33 13 10 30.3 -0.45 1.0e-01 CTB-75G16.3 CTC-498M16.2 ELOVL7 FOXO3 GPX1 JMJD1C-AS1 MEF2C MST1R NEGR1 NEK4 NRBF2 SUOX SYPL2
Arm fat percentage (right) 3.68 14 8 24.2 0.60 2.3e-02 CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 IFT57 MPP6 MST1R NEGR1 RSRC2 SULT1A1 TEX15 THEM6
Trunk fat-free mass 2.69 15 9 27.3 -0.26 3.4e-01 AKTIP C12orf65 CTC-498M16.2 DYNLL1 ELOVL7 FOXO3 GPX1 MEF2C MST1R NEGR1 PPA2 RSRC2 SULT1A1 SUOX WDR24
Hip circumference 3.26 12 10 30.3 0.18 5.8e-01 AKTIP C12orf65 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 MST1R NEGR1 RSRC2 SULT1A1 TEX15 THEM6
Alcohol intake versus 10 years previously 3.57 4 0 0.0 0.62 3.8e-01 GPX1 MST1R NEGR1 RP11-7O11.3
Father's age at death 2.12 1 0 0.0 0.00 1.0e+00 GPX1
Worrier / anxious feelings 2.41 4 1 3.0 0.65 3.5e-01 AP001877.1 B3GALTL NEK4 PLCL2
Frequency of tiredness / lethargy in last 2 weeks 2.52 2 0 0.0 0.00 1.0e+00 GPX1 JMJD1C-AS1
Number of live births 1.69 1 0 0.0 0.00 1.0e+00 MST1R
Forced expiratory volume in 1-second (FEV1) 1.93 6 2 6.1 -0.60 2.1e-01 BCDIN3D GPX1 GRK4 PPA2 PPP2R2D SUOX
Pulse rate 1.29 1 1 3.0 0.00 1.0e+00 AKTIP
Noisy workplace 3.69 1 0 0.0 0.00 1.0e+00 MARK4
Qualifications: A levels/AS levels or equivalent 10.09 33 17 51.5 -0.98 1.1e-25 AKTIP AP001877.1 C12orf65 CAMKMT CCDC18 CDH9 CELF2 CHST10 DBN1 ELOVL7 GPX1 GRK4 IFT57 JMJD1C-AS1 MARK4 MED8 MPP6 MST1R NEGR1 NPM3 NRBF2 PLCL2 PPA2 PPP2R2D RP11-7O11.3 ST3GAL3 ST6GAL2 SULT1A1 SUOX TEX15 THEM6 TSNARE1 WDR24
Mouth/teeth dental problems: Dentures 3.34 4 1 3.0 0.98 1.6e-02 BCDIN3D CCDC18 GPX1 MST1R
Asthma 1.85 1 1 3.0 0.00 1.0e+00 SUOX
Prospective memory result 2.44 1 0 0.0 0.00 1.0e+00 PLCL2
Illnesses of mother 1.60 1 0 0.0 0.00 1.0e+00 CTB-75G16.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.04 4 3 9.1 -0.02 9.8e-01 GPX1 PLCL2 PPA2 SUOX
Impedance of arm (left) 3.38 12 10 30.3 -0.71 9.9e-03 CTB-75G16.3 CTC-498M16.2 ELOVL7 FOXO3 GPX1 JMJD1C-AS1 MEF2C MST1R NEGR1 NEK4 NRBF2 SUOX
Arm fat mass (right) 4.10 14 10 30.3 0.56 3.6e-02 CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 IFT57 MST1R NEGR1 RSRC2 SULT1A1 SUOX TEX15 THEM6
Trunk predicted mass 2.70 15 9 27.3 -0.26 3.3e-01 AKTIP C12orf65 CTC-498M16.2 DYNLL1 ELOVL7 FOXO3 GPX1 MEF2C MST1R NEGR1 PPA2 RSRC2 SULT1A1 SUOX WDR24
Standing height 2.07 14 12 36.4 -0.95 3.4e-07 AKTIP C12orf65 CAMKMT FOXO3 GPX1 GRK4 MED8 MPP6 NEK4 NRBF2 PPA2 PPP2R2D RSRC2 WDR24
Exposure to tobacco smoke at home 2.10 2 0 0.0 0.00 1.0e+00 GPX1 MST1R
Seen doctor (GP) for nerves, anxiety, tension or depression 2.40 2 1 3.0 0.00 1.0e+00 B3GALTL NEGR1
Birth weight of first child 2.06 2 1 3.0 0.00 1.0e+00 PPA2 SUOX
Peak expiratory flow (PEF) 1.41 1 0 0.0 0.00 1.0e+00 FOXO3
Ever highly irritable/argumentative for 2 days 2.44 2 1 3.0 0.00 1.0e+00 GPX1 MST1R
Qualifications: O levels/GCSEs or equivalent 7.86 17 3 9.1 -0.98 8.0e-12 AP001877.1 C12orf65 CAMKMT CTB-75G16.3 ELOVL7 GPX1 GRK4 IFT57 MARK4 MPP6 PLCL2 PPP2R2D RP11-7O11.3 ST3GAL3 ST6GAL2 THEM6 TSNARE1
Medication: Paracetamol 2.28 2 0 0.0 0.00 1.0e+00 CCDC18 GPX1
Headache pain in last month 1.36 1 0 0.0 0.00 1.0e+00 SUOX
Hypothyroidism/myxoedema (self-reported) 1.68 1 1 3.0 0.00 1.0e+00 SUOX
Medication: Ventolin 100micrograms inhaler 1.66 1 0 0.0 0.00 1.0e+00 SUOX
Birth weight 1.65 2 0 0.0 0.00 1.0e+00 PPA2 SUOX
Chronic bronchitis/emphysema (mother) 1.58 1 0 0.0 0.00 1.0e+00 MST1R
Forced vital capacity (FVC), Best measure 1.71 7 2 6.1 0.08 8.7e-01 BCDIN3D GPX1 GRK4 MST1R PPA2 RSRC2 SUOX
Body fat percentage 3.74 15 9 27.3 0.61 1.5e-02 CAMKMT CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 MPP6 MST1R NEGR1 RP11-7O11.3 RSRC2 SULT1A1 TEX15 THEM6
Leg fat percentage (right) 4.82 20 10 30.3 0.72 3.1e-04 AP001877.1 BNIP3 CAMKMT CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 IFT57 MPP6 MST1R NEGR1 NRBF2 RP11-7O11.3 RSRC2 SULT1A1 TEX15 THEM6 WDR24
Arm fat-free mass (right) 2.94 13 11 33.3 -0.12 6.9e-01 AKTIP C12orf65 CTC-498M16.2 ELOVL7 FOXO3 GPX1 MEF2C MST1R NEGR1 PPA2 RSRC2 SULT1A1 SUOX
Exposure to tobacco smoke outside home 2.75 2 0 0.0 0.00 1.0e+00 ELOVL7 MST1R
Comparative body size at age 10 3.10 6 5 15.2 -0.02 9.7e-01 BCDIN3D CTB-75G16.3 CTC-498M16.2 MEF2C NEGR1 SULT1A1
Number of full brothers 1.84 1 0 0.0 0.00 1.0e+00 GPX1
Worry too long after embarrassment 2.26 3 0 0.0 0.00 1.0e+00 BCDIN3D DBN1 THEM6
Wheeze or whistling in the chest in last year 2.41 2 1 3.0 0.00 1.0e+00 GPX1 MST1R
Reason for reducing amount of alcohol drunk: Health precaution 2.11 2 0 0.0 0.00 1.0e+00 CTC-498M16.2 SUOX
Age at first live birth 5.67 8 2 6.1 -0.98 1.5e-05 AP001877.1 BCDIN3D GPX1 MST1R RP11-7O11.3 ST6GAL2 SUOX WDR24
Health satisfaction 1.73 2 0 0.0 0.00 1.0e+00 GPX1 TSNARE1
Qualifications: College or University degree 12.87 42 33 100.0 -0.98 2.8e-29 AKTIP AP001877.1 B3GALTL BCDIN3D BNIP3 C12orf65 C14orf156 CAMKMT CCDC18 CDH9 CELF2 CHST10 CTB-75G16.3 CTC-498M16.2 DBN1 DYNLL1 ELOVL7 FOXO3 GPX1 GRK4 IFT57 JMJD1C-AS1 MARK4 MED8 MPP6 MST1R NEGR1 NPM3 NRBF2 PPA2 PPP2R2D RARS2 RP11-7O11.3 RSRC2 ST3GAL3 ST6GAL2 SULT1A1 SUOX TEX15 THEM6 TSNARE1 WDR24
Medication for pain relief, constipation, heartburn 2.57 5 0 0.0 0.18 7.8e-01 C12orf65 DYNLL1 GPX1 ST6GAL2 TEX15
Neck or shoulder pain in last month 1.89 2 0 0.0 0.00 1.0e+00 GPX1 SUOX
Medication: Blood pressure 1.74 1 0 0.0 0.00 1.0e+00 NEK4
Mean time to correctly identify matches 1.91 2 1 3.0 0.00 1.0e+00 FOXO3 IFT57
Whole body fat mass 3.86 14 10 30.3 0.54 4.5e-02 CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 IFT57 MPP6 MST1R NEGR1 RSRC2 SULT1A1 TEX15 THEM6
Leg fat mass (right) 4.57 16 10 30.3 0.59 1.7e-02 CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 IFT57 MPP6 MST1R NEGR1 NRBF2 RSRC2 SULT1A1 SUOX TEX15 THEM6
Arm predicted mass (right) 2.96 13 12 36.4 -0.10 7.4e-01 AKTIP C12orf65 CTC-498M16.2 ELOVL7 FOXO3 GPX1 MEF2C MST1R NEGR1 PPA2 RSRC2 SULT1A1 SUOX
Pulse rate, automated reading 1.71 3 2 6.1 0.00 1.0e+00 AKTIP CTC-498M16.2 NEGR1
Alcohol intake frequency. 3.90 11 3 9.1 0.81 2.5e-03 B3GALTL BNIP3 C12orf65 CTC-498M16.2 MST1R NEGR1 SULT1A1 SUOX TEX15 TSNARE1 WDR24
Comparative height size at age 10 2.08 12 10 30.3 -0.69 1.3e-02 AKTIP BCDIN3D C12orf65 CAMKMT CCDC18 FOXO3 MED8 NEK4 RP11-7O11.3 RSRC2 SULT1A1 WDR24
Suffer from 'nerves' 1.96 3 0 0.0 0.00 1.0e+00 B3GALTL CTC-498M16.2 SULT1A1
Overall health rating 5.26 9 5 15.2 0.99 1.7e-07 AKTIP B3GALTL GPX1 GRK4 MST1R PPP2R2D TEX15 THEM6 TSNARE1
Age at last live birth 4.24 3 2 6.1 0.00 1.0e+00 AP001877.1 GPX1 MST1R
Leg pain on walking 1.68 2 0 0.0 0.00 1.0e+00 GPX1 MST1R
Commuting to job workplace: Car/motor vehicle 1.66 1 0 0.0 0.00 1.0e+00 NEGR1
Knee pain experienced in last month 2.37 1 0 0.0 0.00 1.0e+00 MST1R
Hypertension (Self-reported) 2.24 8 0 0.0 0.62 1.0e-01 AKTIP MPP6 NEGR1 NRBF2 RSRC2 SUOX TEX15 TSNARE1
Whole body fat-free mass 2.83 15 11 33.3 -0.23 4.0e-01 AKTIP BCDIN3D C12orf65 CTC-498M16.2 ELOVL7 FOXO3 GPX1 MEF2C MST1R NEGR1 PPA2 RSRC2 SULT1A1 SUOX WDR24
Leg fat-free mass (right) 2.82 17 10 30.3 -0.19 4.5e-01 AKTIP BCDIN3D C12orf65 CTB-75G16.3 CTC-498M16.2 ELOVL7 FOXO3 GPX1 IFT57 MST1R NEGR1 PPA2 PPP2R2D RSRC2 SULT1A1 SUOX WDR24
Arm fat percentage (left) 3.54 15 8 24.2 0.62 1.4e-02 CAMKMT CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 IFT57 MPP6 MST1R NEGR1 RSRC2 SULT1A1 TEX15 THEM6
Average weekly red wine intake 4.62 7 1 3.0 -0.98 7.3e-05 AP001877.1 CAMKMT CCDC18 CTC-498M16.2 MST1R NRBF2 RP11-7O11.3
Handedness (chirality/laterality): Left-handed 1.46 1 0 0.0 0.00 1.0e+00 SULT1A1
Mood swings 2.65 4 1 3.0 0.65 3.5e-01 CELF2 GPX1 MST1R PLCL2
Loneliness, isolation 2.27 2 0 0.0 0.00 1.0e+00 GPX1 JMJD1C-AS1
Long-standing illness, disability or infirmity 1.69 1 0 0.0 0.00 1.0e+00 NEGR1
Diabetes diagnosed by doctor 1.64 1 0 0.0 0.00 1.0e+00 AKTIP
Friendships satisfaction 1.93 1 0 0.0 0.00 1.0e+00 AP001877.1
Qualifications: nursing, teaching 7.11 13 3 9.1 -0.98 1.8e-10 AP001877.1 B3GALTL C12orf65 ELOVL7 GPX1 JMJD1C-AS1 LIN52 MEF2C MST1R NEGR1 PPA2 RP11-7O11.3 ST3GAL3
Mouth/teeth dental problems: Mouth ulcers 1.52 1 0 0.0 0.00 1.0e+00 AP001877.1
Medication for cholesterol 1.84 1 0 0.0 0.00 1.0e+00 AKTIP
Mineral and other dietary supplements 2.36 3 0 0.0 0.00 1.0e+00 CTC-498M16.2 GRK4 NRBF2
Asthma (self-reported) 1.88 2 1 3.0 0.00 1.0e+00 MST1R SUOX
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.73 1 0 0.0 0.00 1.0e+00 PPA2
Whole body water mass 2.85 14 11 33.3 -0.20 4.7e-01 AKTIP C12orf65 CTC-498M16.2 ELOVL7 FOXO3 GPX1 MEF2C MST1R NEGR1 PPA2 RSRC2 SULT1A1 SUOX WDR24
Leg predicted mass (right) 2.81 16 10 30.3 -0.23 3.7e-01 AKTIP BCDIN3D C12orf65 CTB-75G16.3 CTC-498M16.2 ELOVL7 FOXO3 GPX1 MST1R NEGR1 PPA2 PPP2R2D RSRC2 SULT1A1 SUOX WDR24
Arm fat mass (left) 3.97 14 10 30.3 0.57 3.5e-02 CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 IFT57 MST1R NEGR1 RSRC2 SULT1A1 SUOX TEX15 THEM6
Number of self-reported non-cancer illnesses 1.94 1 1 3.0 0.00 1.0e+00 NEGR1
Average weekly champagne plus white wine intake 3.20 2 0 0.0 0.00 1.0e+00 SULT1A1 WDR24
Miserableness 3.24 4 3 9.1 1.00 1.3e-03 B3GALTL CELF2 GPX1 MST1R
Guilty feelings 1.90 1 0 0.0 0.00 1.0e+00 GPX1
Financial situation satisfaction 2.14 1 1 3.0 0.00 1.0e+00 GPX1
Commuting to job workplace: Public transport 2.88 2 0 0.0 0.00 1.0e+00 CHST10 NEGR1
Eye problems/disorders: Glaucoma 1.26 1 0 0.0 0.00 1.0e+00 TEX15
Supplements: Fish oil (including cod liver oil) 2.02 1 0 0.0 0.00 1.0e+00 GRK4
Medication: Bendroflumethiazide 1.71 1 1 3.0 0.00 1.0e+00 TEX15
Medication: Paracetamol 2.18 2 0 0.0 0.00 1.0e+00 CCDC18 GPX1
Ever smoked 2.11 1 0 0.0 0.00 1.0e+00 WDR24
Basal metabolic rate 3.02 15 11 33.3 -0.02 9.4e-01 AKTIP C12orf65 CTB-75G16.3 CTC-498M16.2 ELOVL7 FOXO3 GPX1 IFT57 MEF2C MST1R NEGR1 PPA2 RSRC2 SULT1A1 SUOX
Leg fat percentage (left) 4.91 18 12 36.4 0.70 1.2e-03 BNIP3 CAMKMT CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 IFT57 MPP6 MST1R NEGR1 NRBF2 RSRC2 SULT1A1 TEX15 THEM6 WDR24
Arm fat-free mass (left) 3.18 14 12 36.4 -0.03 9.2e-01 AKTIP C12orf65 CTB-75G16.3 CTC-498M16.2 ELOVL7 FOXO3 GPX1 MEF2C MST1R NEGR1 PPA2 RSRC2 SULT1A1 SUOX
Number of operations (self-reported) 2.23 2 0 0.0 0.00 1.0e+00 MST1R PPA2
Average weekly beer plus cider intake 3.23 2 2 6.1 0.00 1.0e+00 MST1R NRBF2
Irritability 1.48 1 0 0.0 0.00 1.0e+00 CELF2
Ever had prostate specific antigen (PSA) test 1.79 1 0 0.0 0.00 1.0e+00 CTC-498M16.2
Age started oral contraceptive pill 2.13 2 0 0.0 0.00 1.0e+00 GPX1 IFT57
Diastolic blood pressure, automated reading 2.55 9 4 12.1 0.57 1.1e-01 C12orf65 GPX1 MED8 MPP6 MST1R NRBF2 ST6GAL2 THEM6 TSNARE1
Unable to work because of sickness or disability 2.80 1 0 0.0 0.00 1.0e+00 ELOVL7
Myopia 1.76 1 0 0.0 0.00 1.0e+00 RP11-7O11.3
Vascular/heart problems diagnosed by doctor 2.26 8 0 0.0 -0.51 2.0e-01 MED8 NEGR1 NRBF2 PPP2R2D RSRC2 SUOX TEX15 TSNARE1
Pain experienced in last month 2.85 3 1 3.0 0.00 1.0e+00 GPX1 MST1R SUOX
Pack years of smoking 2.91 2 1 3.0 0.00 1.0e+00 GPX1 JMJD1C-AS1
Impedance of whole body 2.97 15 11 33.3 -0.36 1.7e-01 CTB-75G16.3 CTC-498M16.2 ELOVL7 FOXO3 GPX1 IFT57 JMJD1C-AS1 MEF2C MST1R NEGR1 NEK4 NRBF2 PPA2 SUOX SYPL2
Leg fat mass (left) 4.63 15 11 33.3 0.58 2.3e-02 CHST10 CTB-75G16.3 CTC-498M16.2 FOXO3 GPX1 GRK4 IFT57 MPP6 MST1R NEGR1 RSRC2 SULT1A1 SUOX TEX15 THEM6
Arm predicted mass (left) 3.20 14 12 36.4 -0.02 9.4e-01 AKTIP C12orf65 CTB-75G16.3 CTC-498M16.2 ELOVL7 FOXO3 GPX1 MEF2C MST1R NEGR1 PPA2 RSRC2 SULT1A1 SUOX

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 17 0.487 2.17
GTEx Adipose Visceral Omentum 12 0.589 2.31
GTEx Adrenal Gland 4 0.275 2.00
GTEx Artery Aorta 18 0.605 2.18
GTEx Artery Coronary 3 0.254 2.18
GTEx Artery Tibial 26 0.691 2.24
GTEx Brain Caudate basal ganglia 5 0.543 2.22
GTEx Brain Cerebellar Hemisphere 9 0.604 2.36
GTEx Brain Cerebellum 10 0.505 2.29
GTEx Brain Cortex 7 0.676 2.23
GTEx Brain Frontal Cortex BA9 5 0.541 2.31
GTEx Brain Hippocampus 2 0.382 2.21
GTEx Brain Hypothalamus 1 0.169 1.99
GTEx Brain Nucleus accumbens basal ganglia 3 0.347 2.26
GTEx Brain Putamen basal ganglia 3 0.481 2.16
GTEx Breast Mammary Tissue 13 0.659 2.34
GTEx Breast Mammary Tissue (Male) 3 0.251 2.09
GTEx Breast Mammary Tissue (Female) 12 0.730 2.27
GTEx Cells EBV-transformed lymphocytes 6 0.422 2.18
GTEx Cells Transformed fibroblasts 24 0.572 2.24
GTEx Colon Sigmoid 10 0.684 2.45
GTEx Colon Transverse 12 0.581 2.22
GTEx Esophagus Gastroesophageal Junction 7 0.484 2.31
GTEx Esophagus Mucosa 19 0.572 2.25
GTEx Esophagus Muscularis 22 0.681 2.25
GTEx Heart Atrial Appendage 9 0.570 2.30
GTEx Heart Left Ventricle 8 0.523 2.23
GTEx Liver 4 0.558 2.16
GTEx Lung 16 0.557 2.22
GTEx Muscle Skeletal 18 0.623 2.28
GTEx Nerve Tibial 24 0.555 2.19
GTEx Ovary 6 0.661 2.28
GTEx Pancreas 15 0.919 2.34
GTEx Pituitary 4 0.359 2.20
GTEx Prostate 6 0.719 2.16
GTEx Skin Not Sun Exposed Suprapubic 16 0.651 2.26
GTEx Skin Sun Exposed Lower leg 18 0.495 2.19
GTEx Small Intestine Terminal Ileum 4 0.868 2.18
GTEx Spleen 7 0.496 2.29
GTEx Stomach 12 0.825 2.37
GTEx Testis 15 0.475 2.26
GTEx Thyroid 19 0.475 2.25
GTEx Uterus 1 0.176 2.11
GTEx Vagina 5 0.787 2.21
GTEx Whole Blood 6 0.301 2.12
METSIM Adipose 17 0.369 2.10
NTR Blood 5 0.208 2.01
ROSMAP Brain Pre-frontal Cortex 19 0.433 2.21
YFS Blood 15 0.325 1.98
CommonMind Brain Pre-frontal Cortex 17 0.316 2.05
TCGA Breast Tumor 3 0.391 2.22
TCGA Breast Normal 14 0.333 1.95
TCGA Ovarian Tumor 10 0.342 1.94
TCGA Prostate Tumor 13 0.376 2.09