Hub : Genes

IFT57

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1500 0.0340 6.7e-12 0.134 0.105 0.120 0.122 0.128 5.1e-16 1e-12 2.3e-14 1.3e-14 2.6e-15
2 GTEx Adrenal Gland 0.2132 0.0732 7.8e-04 0.104 NA 0.085 NA 0.112 1.5e-04 NA 5.7e-04 NA 8.2e-05
3 GTEx Brain Cortex 0.2170 0.0790 3.7e-03 0.031 NA 0.126 NA 0.132 4.8e-02 NA 2.4e-04 NA 1.7e-04
4 GTEx Cells Transformed fibroblasts 0.1200 0.0460 2.9e-03 0.031 NA 0.035 NA 0.030 2.1e-03 NA 1.1e-03 NA 2.4e-03
5 GTEx Colon Transverse 0.1430 0.0470 8.0e-05 0.108 NA 0.157 NA 0.155 8.0e-06 NA 6.1e-08 NA 7.7e-08
6 GTEx Lung 0.1251 0.0412 1.4e-04 0.020 NA 0.033 NA 0.028 1.0e-02 NA 1.5e-03 NA 3.1e-03
7 GTEx Pancreas 0.2390 0.0740 1.5e-04 0.100 NA 0.119 NA 0.111 5.5e-05 NA 1.0e-05 NA 2.2e-05
8 GTEx Skin Not Sun Exposed Suprapubic 0.1800 0.0670 1.9e-03 -0.005 NA 0.007 NA -0.005 7.8e-01 NA 1.3e-01 NA 7.6e-01
9 GTEx Skin Sun Exposed Lower leg 0.1050 0.0400 8.0e-04 0.088 NA 0.058 NA 0.060 9.5e-08 NA 1.5e-05 NA 9.8e-06
10 NTR Blood 0.0249 0.0088 1.6e-04 0.000 0.009 0.006 0.009 0.002 2.2e-01 4e-04 3.2e-03 5.4e-04 7.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 3.8 6.0 14.2 -2.6 -2.4 -0.4 -0.3 -2.4 -1.0 -2.9 -2.4 -3.8 -3.5
Bipolar Disorder or Schizophrenia 4.1 9.9 21.7 -3.9 -3.6 -1.5 -0.8 -1.8 1.1 -4.6 -2.6 -3.7 -4.7
Depressed Affect (Nagel 2018) 2.0 4.3 12.3 2.0 1.7 -0.8 -3.5 -0.3 -2.4 3.0 0.2 -1.6 2.3
Depression (Nagel 2018) 1.1 1.6 6.7 0.4 0.0 -0.7 -2.6 -1.5 -1.4 0.6 -0.4 -1.9 -0.8
Intelligence (Savage-Jansen 2018) 1.8 5.4 22.4 0.1 -0.2 1.9 -1.9 4.7 0.5 0.2 -3.4 -1.9 3.0
Neuroticism (Nagel 2018) 1.5 3.4 9.5 1.6 1.3 -1.2 -3.1 0.5 -1.9 2.7 -0.5 -1.6 2.2
Schizophrenia (2018) 2.5 5.2 12.6 -2.9 -2.7 -1.7 -0.8 -0.4 2.2 -3.5 -1.5 -1.7 -3.1
Schizophrenia vs Biploar Disorder 1.6 2.1 8.0 -1.1 -1.6 -1.4 -1.2 1.5 2.8 -1.2 -0.7 1.3 -0.7
Worry (Nagel 2018) 0.8 1.7 4.6 1.6 1.4 -0.4 -1.7 0.5 -0.9 1.9 -0.4 -0.5 2.1
Alzheimer’s Disease (in mother) 0.8 1.0 5.4 -0.2 -0.3 0.5 -0.4 2.3 1.5 -1.1 -0.3 -0.5 0.5
Alzheimer’s Disease (in father) 0.9 1.0 2.7 0.9 0.9 0.4 1.1 -1.6 -1.4 0.4 1.3 0.1 -0.7
Alzheimer’s Disease (including proxy) 0.2 0.3 0.8 0.8 0.7 -0.1 0.1 0.2 -0.5 -0.0 0.9 0.3 0.3
Crohns Disease (2017) 0.5 1.2 5.1 0.2 0.4 1.3 -0.0 -1.6 -2.2 0.6 -1.3 -0.1 0.4
Irritable Bowel Disease (IBD) 0.4 1.1 2.9 0.6 0.8 1.0 0.5 -1.7 -1.4 0.6 -0.2 1.5 0.9
Ulcerative Colitis (UC) 0.6 1.1 3.1 1.1 1.2 0.3 0.2 -1.5 -0.8 0.8 0.8 1.8 1.1
Major Depression (MDD) 1.3 1.6 6.0 -1.5 -1.4 -0.6 -1.0 0.3 0.9 -0.8 -0.2 -2.4 -1.7
Reaction Time 2.4 4.5 20.5 0.4 0.5 0.7 -1.0 3.4 2.2 0.3 -2.4 -4.5 0.1
Verbal and Numeric Reasoning (VNR) 1.8 4.4 18.1 0.5 0.0 1.4 -2.6 4.3 0.1 0.6 -1.8 -2.4 2.8
Breast Cancer 0.2 0.5 1.8 -0.0 -0.1 -0.4 1.4 -1.0 -0.4 -0.7 -0.6 1.0 0.5
Ovarian Cancer 0.6 0.8 4.2 -0.0 0.2 0.4 0.9 2.0 0.0 0.7 1.1 -1.0 0.3
Prostate Cancer 0.5 0.6 3.2 -0.0 0.3 -0.3 1.4 -0.1 -1.8 0.6 -0.6 -0.1 -0.6
Age at First Birth 1.0 1.4 4.2 -2.1 -1.5 -1.0 0.4 1.0 -0.2 -1.5 -1.2 -0.9 -1.2
Bipolar Disorder (2011) 1.8 1.7 5.1 -0.4 -0.3 2.2 -1.2 -1.0 -0.5 0.1 -1.9 -2.2 -0.9
Body Mass Index (BMI) (2010) 1.1 1.5 5.9 1.2 1.1 0.0 -1.9 -2.4 -0.5 1.0 -0.3 -0.8 -0.8
Coronary Artery Disease (CAD) 0.9 1.0 4.6 -0.2 -0.5 -1.0 -1.4 -2.1 -0.7 0.1 0.9 -0.9 -0.8
Crohns Disease (2012) 0.5 0.8 2.3 0.6 0.8 1.4 -0.1 -0.8 -1.5 0.5 -1.4 -0.4 0.4
Mean Putamen Volume 1.3 1.4 4.0 1.4 1.2 2.0 0.1 0.9 0.3 1.2 -0.2 0.9 1.9
Fasting Glucose 0.6 0.8 3.6 -0.4 -0.0 0.3 -0.3 -0.1 -0.9 -0.5 -1.4 -1.9 -0.8
HbA1C 0.5 0.6 1.7 1.0 0.5 1.3 0.3 -1.1 -0.4 0.5 -0.1 -0.3 1.1
HDL Cholesterol 1.1 1.8 4.2 -2.0 -1.7 -1.8 0.6 1.4 1.1 -1.7 -0.7 0.9 -0.3
LDL Cholesterol 0.6 1.0 4.1 1.0 0.8 0.2 -0.4 -2.0 -0.2 0.8 1.5 1.1 -0.4
Lupus 0.3 0.4 2.6 0.2 0.3 0.5 0.6 1.6 0.3 -0.1 -0.0 -0.6 -0.3
Neuroticism (2016) 1.0 1.4 4.8 0.9 0.9 1.4 -0.3 1.7 0.2 1.2 0.8 0.5 2.2
Primary Biliary Cirrhosis 0.5 0.7 3.9 0.5 0.5 -0.2 0.5 -2.0 -0.0 0.2 1.3 0.2 -0.7
Rheumatoid Arthritis 0.4 0.6 2.1 0.4 0.1 -0.6 -0.1 1.4 -0.2 0.8 0.5 1.1 1.2
Schizophrenia (2014) 2.9 6.3 12.7 -3.3 -3.1 -1.6 -1.5 0.1 2.1 -3.6 -2.8 -2.0 -3.1
Triglycerides 0.5 0.9 2.8 1.1 1.1 1.7 -0.1 -0.5 0.0 0.7 0.8 -1.4 -0.2
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.5 -0.5 -0.6 0.2 0.3 -1.2 0.9 -0.6 -1.2 -0.8 -1.0
Ulcerative Colitis 0.3 0.4 1.4 0.7 0.7 0.4 -0.2 -0.5 -0.5 0.6 0.1 1.0 1.2
Blood Eosinophil Count 0.3 2.4 5.8 -0.5 -0.8 1.1 -1.8 -2.4 -1.3 -0.9 -2.2 -1.9 -1.4
Blood Platelet Count 0.7 8.1 30.6 -1.3 -1.7 4.8 -1.5 2.6 2.6 -2.0 -5.5 -1.4 0.8
Blood Red Count 0.1 1.0 2.2 1.1 0.9 1.2 -0.2 -0.6 -1.5 1.1 1.4 -0.4 0.7
Blood White Count 0.3 2.0 12.0 -0.2 -0.6 3.5 0.2 -0.9 0.1 -0.7 -2.2 -1.1 -0.5
Heel T-Score 0.2 1.5 6.4 0.7 0.9 2.5 1.1 0.4 -1.0 1.3 0.9 -1.3 0.7
BMI 2.7 15.5 39.3 4.7 4.5 -1.2 -3.1 -6.3 -4.5 4.4 3.2 -2.8 -1.8
Height 0.1 2.2 6.8 -0.5 -0.7 2.5 -1.5 1.2 0.2 -1.4 1.2 -2.6 -0.2
Waist Hip Ratio (WHR) 0.3 1.4 4.1 -0.4 -0.4 2.0 0.2 -0.3 1.9 -1.9 0.9 -1.4 -0.2
Systolic Blood Pressure 0.3 1.4 4.7 -0.6 -0.7 1.1 1.8 1.7 2.2 -1.0 -0.6 0.1 0.5
Smoking Status 2.0 4.9 19.7 -1.2 -0.9 -1.1 1.3 -4.4 -0.8 -2.5 1.2 0.5 -3.9
Allergy or Eczema 1.4 3.6 15.6 -0.8 -0.9 -0.3 -3.3 2.4 0.6 -0.7 -1.5 -3.9 -0.2
Cardiovascular Disease 0.6 1.8 4.8 2.2 2.2 -0.7 -0.6 -0.5 -0.7 1.9 0.5 -1.0 1.5
Hypothyroidism (self reported) 1.3 3.1 9.4 1.4 1.1 -0.2 0.5 -0.2 0.4 1.3 3.1 2.5 3.1
Respiratory disease 0.3 0.7 3.3 0.3 -0.3 -0.4 -1.8 -1.3 -0.2 -0.2 -1.2 -0.4 -0.0
Type 2 Diabetes (T2D) (2018) 1.2 2.3 3.5 1.7 1.9 -0.3 -1.3 -1.6 -1.8 1.2 1.8 -1.8 -1.1
Lung FEV1/FVC ratio 0.3 1.4 7.3 0.0 0.1 -0.0 0.1 -2.7 -2.3 0.4 -0.9 0.9 0.2
Lung FVC 0.5 2.7 8.5 -1.7 -1.4 -0.6 0.5 0.2 1.7 -2.4 2.9 -0.4 -2.1
Neuroticism 1.1 2.7 5.7 1.7 1.7 -1.3 -1.9 -0.0 -2.3 2.4 0.2 -1.2 1.9
Chronotype (morning person) 1.5 3.4 9.5 1.6 1.3 2.0 0.5 -0.5 -0.9 2.2 -2.4 2.1 3.1
Hair Pigment 0.1 2.0 9.6 -0.9 -1.1 0.3 0.9 2.2 3.1 -1.2 -0.0 -0.3 1.1
Tanning 0.1 1.2 7.1 -0.2 -0.5 -0.9 0.0 -2.7 -1.5 -0.2 0.6 1.2 -0.1
Hand grip strength (left) 1.3 3.3 8.1 -1.6 -1.7 0.1 -0.1 -1.7 1.7 -2.6 2.8 0.9 -2.6
Number of treatments/medications taken 1.5 2.6 7.0 2.2 1.9 1.1 -0.4 -2.7 -1.4 1.9 1.5 0.6 1.0
Average weekly spirits intake 0.3 0.4 1.2 0.9 0.8 -0.3 -0.4 -0.8 -0.3 0.5 1.1 0.3 -0.3
Sensitivity / hurt feelings 1.3 2.2 5.0 1.6 1.2 0.3 -2.2 0.3 -1.7 2.2 -0.4 -0.8 2.2
Frequency of depressed mood in last 2 weeks 1.1 1.6 4.8 0.9 0.9 -0.1 -1.0 -2.0 -2.2 1.1 1.1 -0.9 -1.0
Hearing difficulty/problems: Yes 0.2 0.3 1.9 -0.1 0.1 0.2 -0.4 0.5 -0.7 0.2 0.1 -1.4 -0.1
Relative age of first facial hair 1.9 3.9 7.9 -2.8 -2.6 -2.0 0.7 1.4 2.5 -2.8 -1.4 0.9 -1.2
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 3.4 -1.4 -1.8 -0.8 -0.2 -0.9 0.7 -1.5 -0.3 0.4 -0.6
Ever used hormone-replacement therapy (HRT) 0.3 0.4 2.0 0.0 0.3 -0.1 1.4 0.7 0.8 -0.3 0.1 -0.5 0.2
Ever had hysterectomy (womb removed) 0.7 0.8 4.0 -0.4 0.0 -0.3 2.0 -0.4 0.5 -0.6 1.2 0.4 -1.3
Systolic blood pressure, automated reading 0.5 1.3 3.5 1.5 1.0 1.9 -0.9 0.8 1.0 1.0 -0.6 -0.9 1.4
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 3.6 -1.1 -0.6 -1.8 1.5 -0.3 -1.1 -1.6 -1.2 -1.0 -1.9
Angina 1.3 1.7 5.2 1.9 1.7 0.8 -0.4 -2.3 -1.1 1.0 1.2 0.2 -0.6
Medication for hormone replacement therapy 0.6 0.6 2.2 -0.2 -0.2 0.4 0.1 0.8 1.3 -0.3 -1.5 -0.7 1.0
Vitamin and mineral supplements 1.2 1.7 4.8 0.6 0.8 0.5 -1.4 1.9 -0.1 0.6 -2.2 -1.8 1.4
Supplements: Zinc 0.5 0.5 1.9 -0.4 -0.4 1.0 -0.1 -1.4 0.7 -0.9 0.3 0.0 -0.8
Medication: Co-codamol 1.0 1.1 3.6 1.1 1.1 0.2 0.5 -1.2 0.0 1.2 1.9 1.4 0.1
Medication: Metformin 0.8 1.2 3.5 0.8 1.0 -0.7 0.1 -1.9 -1.8 1.0 1.0 -0.7 -0.5
Diabetes (father) 0.9 1.1 4.2 0.8 0.4 -0.5 -2.1 -1.7 -0.7 1.3 -0.6 -0.6 0.7
Diabetes (mother) 1.0 1.2 4.3 1.3 1.2 -0.2 -2.1 -1.1 -0.9 1.2 0.5 -1.0 0.0
Severe depression (siblings) 0.7 0.8 4.2 0.5 0.2 0.3 -2.1 -0.3 -0.3 0.6 -0.9 -0.9 0.9
Pack years adult smoking proportion 2.8 4.2 14.6 -0.9 -1.0 -0.9 0.9 -3.5 1.2 -1.3 2.5 3.8 -1.7
Impedance of leg (right) 1.7 8.1 14.5 -3.6 -3.6 1.3 2.0 3.7 3.8 -3.8 -2.4 1.1 0.4
Leg fat-free mass (left) 1.7 9.2 19.7 3.5 3.4 -0.7 -2.0 -4.0 -4.4 3.7 3.0 -2.0 -1.1
Trunk fat percentage 2.0 7.9 17.6 3.2 3.1 0.1 -2.4 -3.1 -4.1 3.0 0.1 -4.2 -1.1
Hand grip strength (right) 1.6 4.5 11.2 -2.4 -2.2 -1.0 -0.5 -0.9 2.4 -3.2 2.2 -0.2 -3.3
Townsend deprivation index at recruitment 1.6 2.2 8.9 -1.5 -1.1 -0.8 0.7 -1.1 0.6 -2.0 -1.7 -0.4 -3.0
Current tobacco smoking 2.4 4.0 11.4 -1.6 -1.2 -1.8 1.2 -3.0 0.5 -2.8 1.0 1.3 -3.4
Average weekly fortified wine intake 1.7 2.0 7.0 -0.9 -0.8 0.7 -0.6 1.8 0.0 -0.7 -2.6 -2.5 -0.1
Maternal smoking around birth 0.6 0.9 2.6 1.4 1.2 0.2 -1.6 -0.8 -0.4 1.4 0.5 -0.2 0.6
Fed-up feelings 0.9 1.6 4.6 1.6 1.4 -0.3 -1.5 -1.0 -1.4 2.1 0.1 -0.1 1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 4.3 0.2 0.1 -1.1 -0.8 -2.1 -0.6 0.5 0.1 0.4 -0.4
Relative age voice broke 1.3 2.0 6.8 -1.1 -1.2 -0.7 -0.3 2.0 2.6 -1.8 -0.4 1.4 -0.4
Taking other prescription medications 0.8 1.3 5.7 1.0 0.9 0.2 0.2 -2.4 -1.8 1.1 0.6 0.5 0.3
Age when periods started (menarche) 0.5 1.3 4.5 -0.7 -0.3 -0.1 2.1 -0.5 0.1 -0.8 1.7 1.7 -1.1
Bilateral oophorectomy (both ovaries removed) 1.6 1.9 3.7 -1.9 -1.7 -1.2 0.8 1.7 1.8 -1.6 -1.0 -0.6 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 6.6 0.3 0.8 -0.1 0.4 0.2 -1.4 1.3 0.2 -2.6 -0.8
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.1 -0.4 -0.4 -0.2 0.5 1.0 0.5 0.2 -0.7 -1.1 -0.2
Qualifications: CSEs or equivalent 1.4 1.8 8.4 1.1 0.5 0.4 -0.9 -2.9 0.0 1.5 1.0 1.9 -0.5
Serious illness, injury or assault to yourself 0.3 0.4 1.4 0.2 0.5 -0.4 0.3 -0.3 -0.4 0.4 -0.4 -1.2 -1.1
High blood pressure 0.7 2.0 5.0 2.2 2.2 0.3 -0.6 -0.0 -0.7 1.7 1.0 -0.6 2.1
Hayfever, allergic rhinitis or eczema 1.5 3.3 12.7 -1.0 -0.9 -0.6 -2.8 2.3 0.4 -0.5 -2.1 -3.6 0.2
Multivitamins +/- minerals 1.2 1.5 5.9 -0.8 -1.1 -0.9 0.5 -2.1 0.1 -0.9 2.4 0.5 -1.2
Stomach or abdominal pain in last month 0.2 0.3 1.3 0.4 0.5 0.0 1.2 -0.6 -0.8 -0.2 0.2 -0.3 -0.4
Supplements: Glucosamine 2.3 3.0 8.5 0.7 0.9 -1.4 2.2 -2.0 -1.0 0.8 2.9 2.0 -1.7
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.9 1.3 1.2 1.3 -0.7 -0.3 -0.8 1.2 -0.6 -1.7 1.1
Medication: Atenolol 1.7 2.1 5.9 2.3 2.4 1.5 0.7 -1.8 -1.7 1.1 0.3 -0.1 0.6
Medication: Levothyroxine sodium 1.7 2.9 8.9 1.4 1.2 0.8 1.6 -1.1 -0.0 1.2 3.0 2.9 1.5
Sitting height 0.1 0.8 2.6 0.0 -0.0 1.6 -0.7 -1.1 -0.8 0.0 0.2 -1.6 -0.7
Chronic bronchitis/emphysema (father) 0.9 1.1 2.5 -1.0 -1.3 -1.4 -0.6 -0.5 0.8 -1.1 -1.0 -1.6 -0.4
High blood pressure (mother) 1.0 1.4 5.5 1.1 1.1 1.0 0.5 -0.4 -1.2 1.3 -2.3 0.1 1.1
Body mass index (BMI) 3.4 14.5 28.5 5.0 5.1 -0.4 -1.5 -5.0 -5.3 5.0 2.2 -2.7 -0.9
Impedance of leg (left) 1.5 7.0 14.8 -3.3 -3.3 1.5 1.4 3.4 3.4 -3.9 -2.3 0.6 0.3
Leg predicted mass (left) 1.7 9.2 19.9 3.5 3.5 -0.6 -1.9 -4.0 -4.5 3.7 2.9 -2.1 -1.1
Trunk fat mass 2.4 10.4 21.3 3.8 3.6 0.2 -2.7 -3.9 -4.6 3.5 1.1 -4.2 -1.3
Waist circumference 3.3 12.0 23.9 4.8 4.9 0.5 -1.7 -4.0 -4.4 4.3 1.9 -3.5 -0.4
Number of incorrect matches in round 0.6 1.0 3.6 -0.9 -0.8 0.1 0.9 -1.0 0.7 -1.9 1.1 0.2 -1.3
Past tobacco smoking 1.1 2.1 11.0 1.0 0.7 0.7 -0.4 1.8 0.4 1.0 -1.0 1.6 3.3
Alcohol usually taken with meals 0.3 0.5 1.9 -0.5 -0.1 -0.4 0.6 1.4 -1.1 0.5 0.6 -0.3 -0.5
Nervous feelings 0.2 0.4 1.4 0.2 -0.2 -0.2 -1.2 0.6 0.1 0.1 -1.0 -0.0 0.8
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 3.8 1.7 1.7 -0.4 -0.5 -0.8 -1.9 1.6 1.2 -0.2 0.7
Hearing difficulty/problems with background noise 0.4 0.6 3.1 -0.5 -0.3 -0.1 -0.1 1.8 -0.3 -0.6 -0.2 -1.3 0.1
Hair/balding pattern: Pattern 2 0.5 0.7 2.6 0.7 0.7 1.6 -0.1 -0.5 -0.7 1.2 0.1 -0.4 0.6
Had menopause 0.5 0.6 2.3 0.2 0.4 0.2 0.8 1.5 1.1 0.6 0.4 -0.2 0.9
Had other major operations 2.5 3.0 8.5 2.2 2.3 0.2 0.3 0.0 -2.8 2.9 0.0 -0.3 1.8
Forced vital capacity (FVC) 0.6 2.4 6.2 -2.1 -2.0 -0.6 -1.0 0.9 1.8 -2.5 0.8 -1.0 -1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 4.3 -0.0 0.4 -0.1 0.6 -0.1 -1.0 0.9 0.3 -2.1 -0.6
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 3.2 -0.2 0.1 -1.1 -0.6 0.3 -0.2 0.4 1.8 -0.8 -1.3
Qualifications: None of the above 2.4 5.1 28.3 0.3 0.2 -1.0 1.6 -5.3 -0.4 -0.6 2.5 3.2 -1.3
Financial difficulties in last 2 years 0.5 0.6 1.9 0.8 0.8 1.1 0.8 -1.4 -0.9 0.3 -0.5 0.2 -0.1
Mouth/teeth dental problems 0.8 1.3 3.8 -1.4 -1.1 0.6 1.1 2.0 1.4 -1.3 0.9 0.4 -0.0
Heart attack 0.6 0.7 3.2 0.3 0.1 0.6 -1.1 -1.8 -1.2 -0.6 0.2 -0.7 -0.2
Allergy 0.7 1.5 6.5 0.2 0.3 0.5 2.5 -1.1 0.5 -0.0 1.1 2.4 -0.5
Pain all over the body in last month 0.5 0.5 2.0 0.3 0.2 -1.4 -0.6 -1.2 -0.7 0.6 -0.5 -0.0 0.3
Diabetes (self-reported) 0.7 1.1 2.0 0.7 0.7 -0.4 -1.3 -1.2 -1.4 -0.0 1.3 -1.3 -1.3
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 12.7 -0.5 -0.7 -0.5 -1.0 1.6 0.2 -0.5 -3.6 -0.8 1.5
Medication: Ramipril 0.9 1.2 6.0 0.8 1.0 0.2 1.2 -0.8 -1.1 0.6 2.5 -0.5 -0.5
Medication: Simvastatin 0.6 0.9 2.8 0.4 0.6 -1.0 0.9 -1.7 -1.5 0.8 0.4 -0.1 -0.9
Fluid intelligence score 2.4 4.9 22.0 -1.0 -1.4 -0.3 -2.0 4.7 1.3 -1.1 -2.8 -2.0 2.3
Illnesses of siblings 1.3 1.8 4.4 -1.7 -1.6 -0.7 -0.0 0.2 0.4 -1.9 2.1 1.4 -1.3
Neuroticism score 1.5 3.2 7.6 2.2 2.0 -0.5 -1.7 -0.9 -2.8 2.8 0.7 -0.3 1.8
Weight 2.6 12.6 27.0 4.4 4.3 -0.1 -2.2 -4.6 -5.2 4.2 2.4 -3.1 -1.1
Impedance of arm (right) 1.1 5.2 13.9 -3.0 -3.0 0.7 0.1 3.0 1.7 -2.5 -3.7 -1.3 -0.0
Arm fat percentage (right) 3.2 12.6 27.4 4.4 4.5 0.1 -1.8 -4.4 -5.2 4.3 1.4 -3.8 -1.1
Trunk fat-free mass 0.9 5.4 12.5 2.6 2.6 0.2 -1.0 -3.2 -3.0 2.4 3.5 -0.7 -1.1
Hip circumference 3.0 12.8 29.0 5.0 5.1 0.1 -1.6 -3.4 -4.9 5.4 1.4 -2.7 -0.4
Time employed in main current job 0.8 0.9 8.1 -0.1 -0.0 0.1 -0.8 0.5 0.0 -0.4 0.4 -2.8 -0.3
Alcohol intake versus 10 years previously 1.1 1.7 4.8 2.0 1.6 0.9 -2.2 -1.0 -0.5 1.2 0.6 -1.2 0.8
Father’s age at death 1.2 1.6 3.4 -1.6 -1.5 -0.9 0.1 0.5 1.0 -1.7 -1.8 -0.9 -1.4
Worrier / anxious feelings 0.8 1.6 4.8 1.6 1.7 -0.4 0.8 0.5 -1.2 2.2 -0.0 0.1 1.7
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.8 1.4 0.7 0.0 -1.6 -1.7 -1.1 1.1 0.5 -0.5 0.7
Falls in the last year 0.7 1.0 4.2 -0.3 -0.4 -0.9 1.3 -1.4 0.1 -0.5 1.0 2.0 0.2
Hair/balding pattern: Pattern 3 0.4 0.5 1.1 -0.3 -0.3 -0.5 -0.8 0.8 1.1 -0.9 0.7 -1.1 0.1
Number of live births 0.6 0.9 3.4 0.1 0.2 -0.6 1.8 -1.1 -0.9 0.2 -1.5 -0.4 -0.7
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 4.2 -1.9 -1.8 -0.6 -0.8 0.1 0.8 -2.0 0.9 -0.9 -1.4
Pulse rate 0.4 0.7 3.3 -0.6 -0.8 -1.8 0.1 0.9 0.2 -1.3 -0.3 -0.3 0.1
Happiness 1.8 2.2 8.1 -1.7 -1.4 -2.8 1.4 0.3 1.1 -1.6 0.3 0.5 -1.6
Noisy workplace 1.2 1.5 4.9 0.1 0.1 -0.9 -0.1 -2.2 -1.1 -0.3 2.0 0.7 -1.8
Qualifications: A levels/AS levels or equivalent 2.1 4.8 23.6 -1.5 -1.6 0.9 -0.5 4.9 1.8 -1.0 -2.4 -2.6 1.1
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.8 4.7 1.8 1.7 0.1 -0.5 -1.8 -2.2 1.6 1.1 0.2 0.2
Mouth/teeth dental problems: Dentures 0.7 1.1 5.5 -0.1 -0.1 -0.8 0.5 -2.3 -1.7 0.1 -0.8 0.3 -1.0
Asthma 0.5 1.0 4.2 -0.3 -0.7 -1.2 -1.1 -2.1 -0.9 -0.4 -1.0 -0.1 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.2 -0.7 -0.7 -1.1 1.1 -0.2 -0.8 -0.2 0.4 0.4 0.6
Medication: Cholesterol lowering 0.6 1.0 3.9 1.1 0.9 0.0 -2.0 -0.7 -1.0 1.4 -0.3 -0.5 0.4
Depression (self-reported) 0.5 0.6 1.8 -0.1 -0.2 -0.8 -1.4 0.3 -0.9 0.8 -0.3 -1.3 0.5
Medication: Lansoprazole 1.4 1.7 6.0 1.7 1.5 0.4 -0.3 0.2 -0.6 1.5 2.4 0.9 1.4
Prospective memory result 0.5 0.7 2.3 1.5 1.2 0.7 0.1 0.3 0.3 0.3 1.5 -0.3 0.0
Lung cancer (father) 0.4 0.5 1.2 -0.7 -0.5 0.2 0.3 -0.9 0.5 -0.8 -1.1 -1.0 0.5
Illnesses of mother 1.2 1.5 4.2 -1.5 -1.3 -0.5 1.0 1.8 2.0 -1.1 1.0 0.1 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 3.3 -1.6 -1.6 -0.3 -1.3 -0.3 0.4 -1.8 1.0 -1.1 -1.7
Pulse wave Arterial Stiffness index 0.8 1.0 4.7 0.4 0.2 -0.5 -1.2 -1.3 -1.1 0.1 2.2 0.1 -0.4
Impedance of arm (left) 1.5 6.8 14.0 -3.4 -3.4 0.4 0.2 3.7 2.5 -3.1 -3.7 -1.2 -0.1
Arm fat mass (right) 3.4 14.0 31.7 4.6 4.7 0.0 -1.8 -4.9 -5.6 4.5 2.1 -3.3 -1.2
Trunk predicted mass 0.9 5.1 11.8 2.5 2.6 0.2 -1.0 -3.1 -3.0 2.4 3.4 -0.8 -1.1
Standing height 0.1 1.1 2.8 -1.0 -1.3 0.8 -1.7 0.7 -0.2 -1.2 0.6 -1.4 -0.8
Length of working week for main job 0.9 0.9 5.1 -0.4 -0.7 0.5 -2.2 -1.1 0.1 -1.0 0.6 -0.8 -0.6
Exposure to tobacco smoke at home 0.7 0.8 2.4 -1.1 -1.1 0.0 0.6 -0.6 0.1 -1.1 -1.6 1.0 0.4
Breastfed as a baby 1.7 2.2 8.9 -0.3 -0.2 2.3 -1.7 1.3 0.1 -0.2 -1.7 -3.0 0.5
Tense / ‘highly strung’ 0.3 0.5 2.9 0.5 0.3 -0.7 -1.7 0.5 0.0 0.0 0.6 -0.7 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 5.7 0.6 0.7 -0.9 -2.4 -0.8 -0.6 0.7 -0.5 -1.8 -0.6
Hair/balding pattern: Pattern 4 1.3 3.2 23.7 0.4 0.3 0.9 1.1 -1.2 -0.2 0.0 4.9 1.9 0.2
Birth weight of first child 1.0 1.8 5.0 -0.9 -1.0 -0.9 -1.6 -0.7 0.9 -1.2 -0.3 -2.2 -2.2
Peak expiratory flow (PEF) 0.3 0.7 1.7 -0.9 -0.8 0.2 -0.2 -1.0 0.2 -0.8 1.2 -0.7 -1.3
Pulse wave reflection index 0.7 0.9 2.4 1.0 1.1 1.6 -0.7 0.2 -0.5 1.2 1.1 -0.9 -0.0
Ever highly irritable/argumentative for 2 days 1.6 1.9 8.6 1.9 1.7 -0.7 -0.6 0.3 -1.3 2.9 0.4 0.5 0.9
Loud music exposure frequency 2.0 2.2 5.8 -1.9 -1.9 -2.4 -0.0 -1.4 -0.6 -1.1 0.5 -0.0 -2.2
Qualifications: O levels/GCSEs or equivalent 2.8 4.5 24.7 -0.3 -0.3 0.7 -1.5 5.0 1.5 0.0 -2.3 -2.8 1.2
Mouth/teeth dental problems: Bleeding gums 3.3 4.2 9.5 3.1 2.9 1.6 -2.4 -0.5 -1.6 2.7 -0.7 -1.1 2.1
Blood clot in the leg (DVT) 0.4 0.5 2.2 0.3 0.1 1.2 -1.0 0.2 -0.4 -0.2 -0.1 -0.6 1.5
Medication: Paracetamol 0.8 1.3 2.7 1.6 1.3 0.4 -0.9 -1.5 -0.7 1.2 1.5 0.2 1.2
Headache pain in last month 1.9 3.2 8.6 2.9 2.9 1.4 0.4 -1.2 -1.0 2.7 1.6 1.0 0.6
Medication for cholesterol, blood pressure or diabetes 0.6 1.1 2.5 -1.6 -1.5 -0.0 1.0 0.7 0.6 -1.6 -1.0 0.1 -0.8
Glaucoma (self-reported) 0.7 0.8 4.0 -0.3 -0.2 -2.0 0.1 -0.9 -1.0 -0.2 0.2 0.7 -1.2
Gout (self-reported) 2.1 2.9 8.2 2.9 2.9 1.2 -0.3 -0.5 -1.5 2.5 0.5 -0.5 1.6
Hypothyroidism/myxoedema (self-reported) 1.7 3.3 9.8 1.5 1.2 0.6 0.6 -0.9 0.4 1.4 3.1 3.0 2.6
Medication: Amlodipine 0.2 0.3 1.8 0.5 0.6 0.1 -0.1 -1.3 0.1 -0.2 0.5 -0.6 -0.1
Medication: Ventolin 100micrograms inhaler 0.4 0.6 1.6 -0.5 -0.8 -1.1 -0.5 -1.3 -0.6 -0.5 -0.6 -0.2 -0.9
Birth weight 0.7 1.6 9.2 0.4 0.2 0.6 -0.5 -1.0 1.0 -0.3 3.0 1.7 -1.0
Chronic bronchitis/emphysema (mother) 1.0 1.2 3.7 1.3 1.2 0.5 0.3 -1.9 -1.4 1.2 0.9 0.6 0.4
High blood pressure (siblings) 2.6 3.7 8.4 2.7 2.6 1.5 -0.6 0.5 -1.1 2.9 -2.2 -1.5 1.7
Forced vital capacity (FVC), Best measure 0.6 2.2 6.0 -1.9 -1.8 -0.4 -1.2 0.5 1.3 -2.4 1.2 -1.2 -1.8
Body fat percentage 2.4 9.4 19.8 3.7 3.7 0.1 -1.9 -3.7 -4.5 3.4 0.8 -3.9 -1.2
Leg fat percentage (right) 2.1 7.8 18.2 3.6 3.6 -0.0 -0.5 -4.3 -3.9 3.4 1.6 -1.9 -1.1
Arm fat-free mass (right) 1.2 6.3 13.2 2.9 2.8 -0.4 -1.4 -3.5 -3.2 2.6 3.6 -0.9 -1.0
Exposure to tobacco smoke outside home 0.9 1.2 3.1 1.6 1.3 -0.9 -1.5 0.4 0.3 1.8 0.5 -0.3 1.2
Comparative body size at age 10 0.6 1.5 6.5 -0.3 -0.1 -0.9 1.0 -2.0 -2.5 1.0 1.1 0.8 -0.2
Number of full brothers 0.2 0.3 0.7 0.3 0.1 0.8 -0.2 -0.1 0.7 0.2 -0.9 0.6 0.8
Worry too long after embarrassment 0.7 1.2 3.2 -1.4 -1.4 -1.0 -0.9 1.2 -0.1 -0.8 -1.8 -0.1 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.8 0.4 0.5 -0.9 -0.2 -0.8 -1.4 0.7 -0.2 0.5 0.7
Wheeze or whistling in the chest in last year 1.5 2.7 15.2 0.1 -0.2 -0.9 -1.1 -3.9 -1.7 -0.4 2.0 1.2 -1.1
Number of children fathered 1.4 1.5 3.3 1.6 1.2 0.7 -1.8 -0.4 -1.8 1.8 0.1 0.1 0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 5.1 -1.2 -1.1 -0.9 -0.4 2.0 2.3 -1.5 -1.1 -2.1 0.1
Age at first live birth 1.3 2.3 10.1 -1.0 -0.9 0.7 -1.8 3.2 0.3 -1.2 -1.5 -1.9 0.0
Pulse wave peak to peak time 0.9 1.0 4.4 -0.7 -0.5 0.5 1.3 1.4 1.0 -0.4 -2.1 -0.1 0.1
Health satisfaction 0.7 0.9 2.7 -0.5 -0.3 -0.9 1.2 -1.7 -0.3 -0.5 0.6 0.8 -1.4
Shortness of breath walking on level ground 0.7 0.9 2.3 -0.2 -0.3 -1.5 -0.1 -1.4 -1.5 0.1 1.4 0.2 -0.4
Qualifications: College or University degree 2.2 6.9 34.1 -2.1 -2.2 1.1 -1.3 5.8 2.1 -1.7 -3.1 -1.7 1.6
Eye problems/disorders: None of the above 0.5 0.5 0.9 0.7 0.9 0.3 -0.6 -0.7 -0.9 0.7 0.9 -1.0 -0.1
Mouth/teeth dental problems: Loose teeth 0.7 0.9 2.5 0.8 1.0 -0.4 -0.6 -0.6 -1.1 0.4 -1.5 -1.6 -0.3
Emphysema/chronic bronchitis 0.9 1.1 3.9 0.9 0.4 0.4 -0.7 -2.0 -1.3 0.9 1.0 1.2 0.5
Medication for pain relief, constipation, heartburn 0.9 1.6 7.8 -1.2 -0.9 -0.0 0.3 2.8 1.6 -0.8 -1.2 -0.6 -1.0
Neck or shoulder pain in last month 1.5 2.2 5.7 1.7 1.4 1.1 -0.0 -0.0 0.2 2.0 2.4 1.2 2.1
Medication: Blood pressure 0.5 0.9 1.6 1.3 1.1 -0.1 -1.1 -1.2 -0.4 1.0 1.3 0.2 0.6
Angina (self-reported) 1.2 1.6 5.7 1.7 1.5 0.5 -0.4 -2.4 -1.1 0.8 1.4 0.5 -0.8
Migraine (self-reported) 0.4 0.5 1.9 0.2 0.2 -1.4 -0.6 -0.0 -0.8 1.1 -0.4 -0.5 -0.0
Medication: Ibuprofen 0.4 0.5 1.6 0.6 0.6 0.3 1.1 0.2 -0.5 0.9 0.7 0.1 1.3
Medication: Allopurinol 0.8 1.0 2.7 1.2 1.3 0.2 -0.6 -1.3 -1.6 0.9 -0.2 -1.0 0.2
Medication: Omeprazole 1.6 1.9 3.9 1.8 1.9 0.9 0.4 -1.0 -1.6 1.9 2.0 0.3 0.2
Medication: Seretide 50 evohaler 0.8 0.9 2.9 -0.2 -0.4 -0.5 -0.7 -1.7 -0.4 -0.8 1.3 -0.2 -1.7
Mean time to correctly identify matches 2.7 5.1 20.4 0.3 0.4 1.2 -0.3 4.2 2.2 0.1 -2.3 -4.5 0.8
Heart disease (mother) 0.9 1.1 5.1 -0.1 -0.4 -0.6 -0.8 -2.2 -0.0 -0.6 1.5 1.2 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 2.0 -0.3 -0.4 -0.1 -1.4 0.2 1.3 -0.9 -0.3 -0.8 -0.5
Whole body fat mass 2.8 11.7 25.4 4.2 4.1 -0.0 -2.4 -4.3 -5.0 3.9 1.6 -3.8 -1.2
Leg fat mass (right) 3.1 12.0 25.4 4.3 4.3 -0.1 -1.8 -5.0 -4.9 4.1 2.1 -2.8 -1.0
Arm predicted mass (right) 1.3 6.6 13.6 2.9 2.8 -0.1 -1.4 -3.7 -3.4 2.5 3.6 -1.3 -1.0
Pulse rate, automated reading 0.3 1.1 4.5 1.0 0.7 -0.6 -0.4 2.1 0.2 1.1 -0.3 -0.8 1.5
Alcohol intake frequency. 0.3 0.8 2.9 0.2 -0.2 -1.4 0.4 -0.9 0.6 -0.5 1.0 1.7 -0.4
Comparative height size at age 10 0.4 2.1 7.4 -1.0 -1.2 -0.7 -1.6 -0.6 -1.7 -1.1 -1.1 -2.7 -1.2
Number of full sisters 2.0 2.4 11.2 -1.0 -1.3 -0.4 -1.4 0.7 1.5 -1.2 -3.4 -1.0 -1.7
Suffer from ‘nerves’ 0.3 0.5 1.9 0.2 0.2 -1.4 0.4 0.4 -0.7 0.7 0.2 0.5 1.0
Overall health rating 1.1 2.4 12.9 0.8 0.7 -0.7 0.8 -3.6 -1.1 0.9 2.1 1.5 -0.9
Chest pain or discomfort 0.4 0.6 2.7 0.2 -0.2 -0.8 -1.1 -1.6 -1.1 0.3 0.3 0.3 0.5
Had major operations 0.6 0.7 2.2 0.5 0.4 0.6 -0.4 -1.3 -1.1 0.9 -0.4 -1.5 -0.2
Age at last live birth 0.5 0.7 3.0 -0.3 -0.2 0.2 -0.6 1.4 -0.6 -0.5 -0.5 -1.7 -0.5
Family relationship satisfaction 1.0 1.3 3.4 -1.1 -0.6 -0.8 1.7 0.8 1.2 -1.3 0.7 -0.0 -1.8
Leg pain on walking 0.4 0.5 2.2 0.6 0.6 -0.6 0.3 -0.3 0.9 -0.0 0.9 0.3 -1.5
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.3 0.5 0.5 -0.5 0.7 -0.1 -1.5 0.7 -0.1 -1.1 -0.0
Commuting to job workplace: Car/motor vehicle 1.7 1.9 5.1 1.8 1.3 0.9 -1.4 -1.2 -1.2 2.3 1.5 -0.1 1.3
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 5.3 -1.8 -1.6 -0.1 -0.3 2.3 1.3 -1.8 -0.8 -0.7 -0.9
Medication: Aspirin 0.9 1.2 5.0 -1.0 -1.2 -0.5 0.3 -2.2 0.1 -1.8 0.0 -0.4 -1.0
Supplements: Vitamin C 1.0 1.2 4.4 -0.4 -0.3 -0.3 1.1 -1.2 0.3 -0.6 0.1 2.1 -2.1
Knee pain experienced in last month 1.9 2.9 6.7 2.2 1.8 -0.2 -1.3 -1.5 -1.1 2.6 2.0 1.5 1.8
Hypertension (Self-reported) 0.6 1.6 4.0 2.0 2.0 -0.1 -0.4 0.4 -0.5 1.5 1.1 -0.3 2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.2 0.1 -0.2 -0.1 -0.9 -1.1 -0.1 -0.3 0.9 0.1 -0.0
Illnesses of father: Heart disease 1.5 2.1 4.7 2.1 1.8 1.3 -1.5 -0.2 -1.3 2.2 0.2 -1.0 1.3
Illnesses of siblings: Diabetes 0.5 0.6 1.9 0.6 0.6 -0.6 0.1 -1.2 0.3 1.0 -1.4 -0.1 0.2
Smoking status: Previous 0.9 1.4 4.6 -0.1 -0.1 -0.5 -0.3 -2.2 -1.6 0.2 1.5 -0.7 -1.9
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 1.1 -0.2 -0.4 -0.0 -1.0 -0.5 -0.4 -0.4 -0.3 0.3 0.2
Whole body fat-free mass 1.3 7.2 13.5 3.1 3.1 -0.1 -1.5 -3.6 -3.7 3.1 3.4 -1.5 -1.1
Leg fat-free mass (right) 1.7 9.3 20.5 3.5 3.5 -0.7 -2.2 -4.0 -4.5 3.5 2.9 -2.2 -1.2
Arm fat percentage (left) 2.9 11.4 24.9 4.2 4.3 -0.2 -1.7 -4.1 -5.0 4.1 1.3 -3.7 -1.3
Average weekly red wine intake 1.2 1.8 9.4 -0.9 -0.6 0.2 -1.6 1.4 0.6 -0.5 -1.5 -3.1 -0.2
Handedness (chirality/laterality): Left-handed 0.7 0.9 2.3 1.2 1.3 1.5 -0.2 -0.2 -1.0 1.0 0.4 0.5 1.1
Mood swings 0.7 1.3 3.3 1.1 1.0 -1.1 -1.8 -0.4 -1.2 1.7 0.9 -0.2 -0.1
Loneliness, isolation 0.9 1.2 3.9 1.0 0.9 -0.9 -0.9 -0.4 -1.6 2.0 0.1 0.6 1.4
Long-standing illness, disability or infirmity 0.4 0.6 1.8 0.9 0.7 -0.9 -0.8 -0.8 -1.3 1.0 -0.1 -0.4 0.2
Ever had bowel cancer screening 0.6 0.7 2.5 0.4 0.1 0.7 -1.4 0.7 0.8 0.6 -0.6 -0.8 1.6
Diabetes diagnosed by doctor 1.1 1.8 4.0 0.6 0.6 -1.4 -1.5 -2.0 -2.0 0.2 1.2 -1.5 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 3.5 1.3 1.3 1.9 0.6 -1.8 -1.3 1.6 0.3 0.9 -0.1
Friendships satisfaction 1.2 1.5 3.4 -1.5 -1.1 -1.9 1.2 1.2 1.1 -1.1 -1.2 0.3 -1.0
Qualifications: nursing, teaching 1.4 2.2 11.8 -1.1 -1.1 -0.0 -0.4 3.4 1.6 -1.0 -0.9 -1.8 0.1
Commuting to job workplace: Walk 1.9 2.1 4.5 -1.8 -1.9 -0.6 0.3 1.5 1.8 -1.4 -2.1 0.6 -0.9
Eye problems/disorders: Cataract 1.3 1.5 7.2 0.0 -0.5 0.8 -1.0 2.1 0.9 0.5 -0.9 0.1 2.7
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.5 -0.3 -0.4 -1.6 -0.2 1.4 0.3 0.1 -0.2 -1.3 -0.2
Medication for cholesterol 0.4 0.5 3.6 0.5 0.2 0.7 -1.9 0.2 0.3 0.5 0.7 0.5 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 6.6 0.2 0.3 -1.3 0.9 -2.6 -1.5 0.1 1.8 1.0 -0.5
Back pain experienced in last month 2.2 3.2 10.8 1.7 1.5 -0.9 0.3 -2.3 -0.0 1.7 3.3 2.7 0.5
Mineral and other dietary supplements 0.9 1.2 4.5 -0.0 0.1 0.6 -0.7 1.6 -0.6 0.0 -2.1 -1.3 1.2
Breast cancer (self-reported) 0.7 0.8 3.9 -0.1 0.3 0.9 2.0 0.3 1.3 -0.3 1.1 -0.4 -0.6
Asthma (self-reported) 0.5 1.0 3.6 -0.4 -0.7 -1.1 -1.2 -1.9 -0.6 -0.5 -1.0 -0.2 -1.0
Osteoporosis (self-reported) 0.2 0.3 1.1 0.2 0.5 0.3 1.0 -0.6 -0.7 0.3 -0.5 0.2 0.0
Osteoarthritis (self-reported) 0.9 1.2 2.0 1.4 1.2 -1.4 -0.9 -1.1 -0.9 1.3 1.4 0.7 0.1
Medication: Aspirin 0.8 1.0 5.2 -0.6 -0.6 0.1 0.1 -2.3 -0.3 -1.3 -0.4 -1.1 -1.1
Medication: Gliclazide 0.5 0.5 1.7 0.8 0.8 -0.7 -0.9 -0.3 -1.3 1.0 0.1 0.3 0.1
Illnesses of father: None of the above (group 1) 1.4 1.7 4.8 -1.5 -1.2 0.3 2.2 2.1 0.8 -1.7 -0.1 0.5 -0.9
Smoking status: Current 1.9 3.1 8.7 -1.5 -1.1 -1.5 1.2 -2.5 0.8 -2.7 0.4 1.0 -3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 2.0 -0.5 -0.5 0.3 -0.2 -0.7 0.3 -0.7 1.4 -0.6 -0.1
Whole body water mass 1.3 7.3 14.3 3.1 3.1 -0.1 -1.5 -3.5 -3.8 3.1 3.4 -1.6 -1.0
Leg predicted mass (right) 1.7 8.9 20.3 3.4 3.4 -0.7 -2.1 -3.9 -4.5 3.5 2.8 -2.2 -1.2
Arm fat mass (left) 3.2 13.1 27.7 4.6 4.7 0.0 -1.8 -4.5 -5.3 4.5 1.9 -3.4 -1.2
Number of self-reported non-cancer illnesses 1.3 2.2 5.0 2.2 2.2 0.6 0.1 -1.3 -1.2 2.2 0.9 0.8 1.6
Average weekly champagne plus white wine intake 1.1 1.6 4.3 -2.0 -2.1 -0.6 -0.4 0.6 1.3 -1.6 0.4 0.9 -1.1
Miserableness 1.4 2.5 8.1 1.7 1.5 -0.0 -2.8 -0.9 -1.5 2.4 1.3 -0.3 1.2
Guilty feelings 0.5 0.8 2.3 0.9 1.0 -0.5 0.6 -1.0 -1.2 1.5 0.5 0.6 0.1
Wears glasses or contact lenses 1.1 1.2 4.2 1.3 1.1 0.3 -0.2 2.0 0.6 1.4 -0.3 0.3 1.7
Ever taken oral contraceptive pill 1.8 2.1 6.8 0.4 0.2 1.5 0.6 0.9 2.4 0.4 1.1 2.6 1.7
Hearing aid user 0.3 0.4 2.0 -0.3 0.0 -1.4 0.1 0.3 0.2 0.4 -0.6 -0.8 0.6
Mother’s age at death 0.7 0.9 3.3 -0.4 -0.5 0.2 -0.5 0.4 -1.8 -0.3 -1.8 -1.1 0.6
Financial situation satisfaction 1.0 1.2 4.3 0.1 0.5 -0.2 2.1 -0.6 0.8 -0.5 1.7 0.4 -1.9
Tinnitus: Yes, now most or all of the time 0.5 0.6 3.2 0.3 0.3 0.7 0.6 -0.7 -0.1 -0.4 1.8 0.9 -0.5
Commuting to job workplace: Public transport 3.6 4.3 9.2 -2.4 -2.3 -1.3 0.1 3.0 2.5 -2.8 -1.8 -1.4 -1.5
Eye problems/disorders: Glaucoma 0.4 0.5 1.4 -0.1 -0.3 -0.9 -0.5 0.4 0.2 -0.5 0.0 1.2 -1.2
Medication: Blood pressure 0.2 0.4 2.9 -0.2 0.0 -0.5 1.7 0.2 -0.9 -0.5 0.2 0.3 0.1
Pain type(s) experienced in last month: Hip pain 1.3 1.6 5.5 1.0 0.8 -0.6 0.3 -0.6 -0.5 1.4 1.1 2.4 2.2
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.2 0.4 0.2 -0.1 -0.0 -0.6 1.1 0.3 1.1 0.8 0.3
High cholesterol (Self-reported) 0.3 0.4 2.2 0.1 0.3 -1.5 -0.2 -0.9 -0.3 0.3 1.0 -0.1 -0.3
Medication: Bendroflumethiazide 0.2 0.4 1.2 0.4 0.1 -1.1 -0.8 0.2 -0.6 1.1 -0.4 -0.1 -0.1
Medication: Paracetamol 1.8 2.7 7.6 2.4 2.2 1.4 -0.3 -0.6 -0.7 1.9 2.8 -0.0 1.7
Medication: Lisinopril 0.3 0.4 1.1 -1.0 -0.8 -0.7 -0.3 0.5 0.0 -1.1 -0.4 -0.6 -0.2
Medication: Atorvastatin 1.0 1.2 5.2 0.9 0.9 -0.5 -1.2 -0.8 -2.3 1.1 0.7 -0.8 0.4
Illnesses of father: High blood pressure 0.6 0.8 3.2 -0.3 -0.4 -1.1 -1.5 -0.4 0.2 0.2 -1.8 -0.3 0.4
Alcohol drinker status: Never 0.8 1.0 3.8 -0.5 -0.8 -0.7 0.3 0.6 2.0 -0.6 0.1 1.8 0.5
Ever smoked 2.2 3.8 17.7 -2.0 -1.6 -1.3 0.3 -1.3 -0.0 -2.0 0.3 -2.5 -4.2
Basal metabolic rate 1.6 8.8 17.8 3.5 3.5 -0.1 -1.7 -4.0 -4.2 3.4 3.4 -1.8 -1.2
Leg fat percentage (left) 2.5 9.2 20.0 3.9 4.0 -0.0 -0.9 -4.5 -4.2 3.6 1.7 -2.2 -1.1
Arm fat-free mass (left) 1.5 7.8 14.9 3.3 3.3 0.2 -1.3 -3.7 -3.9 3.0 3.7 -1.3 -0.8
Number of operations (self-reported) 1.1 1.6 3.7 1.7 1.7 -0.1 -0.7 -1.4 -1.7 1.9 0.9 -0.1 0.5
Average weekly beer plus cider intake 0.4 0.6 3.7 -0.1 -0.1 -1.9 -0.1 0.3 0.9 0.0 0.8 0.9 0.3
Irritability 2.4 4.1 7.6 2.7 2.7 -0.8 -2.5 0.5 -1.4 2.3 1.4 -2.8 1.6
Risk taking 0.9 1.3 5.0 -0.8 -0.5 -2.2 -0.6 -1.6 -0.8 -1.0 1.4 -0.4 -0.7
Ever had prostate specific antigen (PSA) test 1.1 1.3 3.9 -1.6 -1.4 -0.5 0.4 -0.2 0.4 -1.8 0.4 0.3 -2.0
Fractured/broken bones in last 5 years 1.1 1.4 3.4 -1.0 -1.2 -0.5 -0.2 1.8 0.8 -1.0 -1.8 -1.8 -0.2
Age started oral contraceptive pill 2.5 3.1 16.1 -1.2 -0.7 -0.1 0.9 4.0 1.4 -0.6 -1.4 -2.7 -0.6
Diastolic blood pressure, automated reading 3.1 9.7 26.4 5.1 4.5 3.2 -2.2 0.8 -0.7 4.4 0.4 -0.6 3.9
Ever depressed for a whole week 0.3 0.4 1.0 0.3 0.8 -0.8 -0.0 0.6 0.2 0.9 1.0 -0.3 -0.5
Unable to work because of sickness or disability 0.9 1.2 4.6 -0.9 -1.0 -2.1 -0.4 -2.1 -0.3 -0.5 0.3 0.1 -0.6
Commuting to job workplace: Cycle 1.0 1.2 3.6 -1.6 -1.4 0.0 0.6 -0.8 0.3 -1.9 -0.6 0.4 -1.7
Myopia 1.2 1.8 5.6 0.4 0.5 0.3 -1.5 1.9 1.3 0.7 -1.5 -2.4 1.5
Vascular/heart problems diagnosed by doctor 0.9 2.4 6.7 -2.6 -2.5 -0.6 0.7 0.6 1.1 -1.8 -1.1 0.3 -2.0
Cholesterol lowering medication 1.2 1.7 4.9 0.1 0.5 -0.9 2.0 -2.2 -1.8 0.2 1.2 0.2 -1.5
Medication: Omeprazole (e.g. Zanprol) 2.4 2.9 6.5 2.5 2.5 1.4 -0.3 -1.1 -1.5 2.3 2.1 -0.2 0.9
Pain experienced in last month 2.8 4.7 11.1 -3.2 -3.1 0.4 -0.0 2.3 1.3 -3.3 -2.7 -1.3 -0.8
Supplements: Calcium 0.7 0.8 2.7 -0.5 -1.1 -0.0 -1.6 -0.3 1.2 -1.0 0.0 1.1 0.2
Basal cell carcinoma (self-reported) 0.5 0.6 2.7 -0.2 -0.1 -0.3 0.9 -1.6 -0.8 0.2 -0.7 -0.9 -0.1
Heart attack/myocardial infarction (self-reported) 0.8 1.1 4.6 0.5 0.3 0.8 -1.3 -2.1 -1.5 -0.3 0.3 -0.8 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 2.2 0.3 0.0 1.1 -1.4 0.3 -0.1 -0.3 -0.3 -0.8 1.5
Heart disease (siblings) 0.5 0.6 1.8 0.1 0.1 -0.7 1.3 -1.2 -1.3 0.1 -0.6 -0.6 0.3
Alcohol drinker status: Previous 0.6 0.7 3.4 -0.5 -0.5 -1.9 0.7 -0.3 1.0 -0.6 -0.2 1.0 -0.6
Pack years of smoking 2.3 3.3 13.2 -0.1 -0.3 -0.4 0.7 -3.2 0.7 -0.5 2.7 3.6 -1.1
Impedance of whole body 1.8 9.3 16.7 -4.0 -4.0 0.8 0.9 4.1 3.5 -4.1 -3.7 -0.7 0.1
Leg fat mass (left) 3.3 12.8 25.4 4.5 4.6 -0.0 -2.0 -5.0 -5.0 4.2 2.1 -2.9 -0.9
Arm predicted mass (left) 1.5 7.8 13.6 3.5 3.4 0.2 -1.3 -3.7 -3.6 3.2 3.6 -1.2 -0.7