TWAS hub - PAX6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0860	0.0280	5.0e-07	0.066	0.060	0.062	0.059	0.003	2.0e-08	8.4e-08	4.4e-08	9.5e-08	1.3e-01
2	TCGA	Breast Invasive Carcinoma	0.0262	0.0140	3.1e-03	0.020	0.016	0.023	NA	0.023	4.9e-05	2.6e-04	1.0e-05	NA	1.6e-05
3	TCGA	Brain Lower Grade Glioma	0.1583	0.0638	1.2e-06	0.040	0.047	0.050	NA	0.043	2.4e-05	4.2e-06	2.2e-06	NA	1.0e-05
4	TCGA	Prostate Adenocarcinoma	0.1052	0.0463	6.4e-05	0.061	0.039	0.051	NA	0.023	6.1e-07	5.5e-05	4.2e-06	NA	1.7e-03
5	TCGA	Thyroid Carcinoma	0.1120	0.0390	2.8e-08	0.107	0.075	0.092	NA	0.094	1.5e-10	9.1e-08	3.0e-09	NA	2.2e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Neuroticism	9.3	22.3	40.6	3.9	4.2	3.4	5.2	6.4
Neuroticism (Nagel 2018)	8.4	19.8	34.7	3.7	4.1	2.6	5.2	5.9
Neuroticism (2016)	8.0	11.6	17.5	3.1	3.2	3.1	3.4	4.2
Neuroticism score	7.6	15.8	31.1	3.0	3.5	2.1	4.6	5.6
Sensitivity / hurt feelings	7.1	12.2	18.1	3.0	3.5	2.4	4.3	4.0
Stomach or abdominal pain in last month	6.2	7.7	11.9	2.6	2.8	0.9	3.4	3.5
Guilty feelings	5.8	8.7	11.4	2.9	2.9	2.3	3.2	3.4
Mother’s age at death	5.6	7.1	9.3	-2.5	-2.8	-1.9	-2.9	-3.0
Worry (Nagel 2018)	5.5	11.6	23.2	2.6	2.8	2.3	3.8	4.8
Irritability	4.9	8.2	18.2	2.0	2.3	0.6	3.6	4.3
Loneliness, isolation	4.8	6.6	8.3	2.5	2.8	1.6	2.9	2.9
Illness, injury, bereavement, stress in last 2 years	4.6	5.6	7.9	-2.8	-2.8	-1.3	-2.5	-2.2
Worrier / anxious feelings	4.5	8.6	18.3	2.0	2.3	1.7	3.5	4.3
Nervous feelings	4.4	8.2	14.9	2.1	2.4	2.5	3.1	3.9
Worry too long after embarrassment	4.2	7.1	13.1	2.0	2.4	1.4	3.2	3.6
Depression (self-reported)	4.1	4.9	9.8	1.6	1.8	1.2	2.7	3.1
Tense / ‘highly strung’	4.1	6.8	12.9	2.1	2.5	1.4	2.9	3.6
Depressed Affect (Nagel 2018)	3.8	8.0	15.7	2.2	2.6	0.9	3.4	4.0
Miserableness	3.8	6.7	12.5	2.2	2.5	0.9	3.0	3.5
Alzheimer’s Disease (in father)	3.7	4.0	4.9	-1.9	-1.7	-2.1	-2.0	-2.2
Maternal smoking around birth	3.7	5.3	7.7	2.3	2.4	0.8	2.8	2.7
Frequency of tenseness / restlessness in last 2 weeks	3.4	5.3	10.2	1.7	2.2	0.9	2.8	3.2
Average weekly spirits intake	3.3	4.0	7.3	2.2	2.0	2.7	1.5	1.4
Breastfed as a baby	3.3	4.1	6.8	2.1	1.7	0.2	2.5	2.6
Suffer from ‘nerves’	3.2	5.0	8.8	1.9	2.0	1.5	2.5	3.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	5.0	-2.0	-1.9	-2.2	-1.8	-1.6
Medication for hormone replacement therapy	2.7	3.0	4.8	-1.6	-1.6	-0.7	-2.2	-2.1
Hair/balding pattern: Pattern 4	2.7	6.6	10.3	-2.6	-2.6	-0.9	-3.2	-2.9
Ever had bowel cancer screening	2.7	3.2	3.9	-1.8	-1.8	-2.0	-1.9	-1.4
Ulcerative Colitis (UC)	2.6	4.9	6.6	2.6	2.4	1.6	2.4	2.0
Supplements: Calcium	2.5	2.8	5.6	-1.2	-1.2	-2.4	-1.4	-1.9
Irritable Bowel Disease (IBD)	2.3	5.5	7.3	2.7	2.5	2.0	2.3	2.2
Frequency of depressed mood in last 2 weeks	2.3	3.3	6.3	1.5	1.8	0.2	2.2	2.5
Mean time to correctly identify matches	2.3	4.3	9.8	-1.9	-2.1	-3.1	-1.5	-1.4
Supplements: Vitamin C	2.2	2.6	3.7	1.9	1.8	1.8	1.3	0.9
High blood pressure (mother)	2.0	2.8	5.5	1.2	1.5	0.7	2.1	2.3
Mood swings	2.0	3.7	9.6	0.9	1.4	-0.0	2.4	3.1
Number of self-reported non-cancer illnesses	2.0	3.5	5.2	2.1	1.9	0.7	2.3	2.0
HbA1C	1.9	2.1	4.6	-1.0	-1.2	-0.9	-1.6	-2.1
Loud music exposure frequency	1.9	2.1	2.9	-1.7	-1.4	-1.7	-1.3	-1.0
Glaucoma (self-reported)	1.9	2.2	2.6	-1.5	-1.3	-1.5	-1.5	-1.6
Chronotype (morning person)	1.8	4.2	5.7	1.8	1.9	2.4	1.8	2.3
Townsend deprivation index at recruitment	1.8	2.5	4.2	1.6	1.6	0.2	1.8	2.1
Medication: Ramipril	1.8	2.3	3.3	1.5	1.5	1.0	1.8	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	5.9	1.1	1.3	0.8	2.1	2.4
Headache pain in last month	1.8	3.1	3.5	1.6	1.8	1.9	1.7	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	2.9	-1.7	-1.6	-1.6	-1.2	-0.9
Major Depression (MDD)	1.7	2.0	4.7	1.1	1.2	0.0	1.7	2.2
Reaction Time	1.7	3.3	8.9	-1.5	-1.7	-3.0	-1.0	-1.1
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.2	-1.2	-1.3	-1.4	-1.4	-1.8
Medication: Paracetamol	1.7	2.9	4.4	1.5	1.5	2.1	1.5	1.9
Medication: Blood pressure	1.7	3.0	5.4	1.5	1.4	1.4	1.9	2.3
Pain type(s) experienced in last month: Hip pain	1.7	2.2	4.5	0.9	1.0	-1.4	1.6	2.1
Ulcerative Colitis	1.6	2.4	4.2	2.1	1.9	0.0	1.4	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	4.5	0.8	1.2	0.8	1.8	2.1
Osteoarthritis (self-reported)	1.6	2.0	4.0	1.4	1.4	0.2	1.5	2.0
Medication: Gliclazide	1.6	1.8	2.9	-1.7	-1.3	-0.1	-1.5	-1.4
Supplements: Zinc	1.5	1.6	2.5	-1.1	-0.9	-1.5	-1.0	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	2.3	1.5	1.5	0.7	1.5	1.2
Pain experienced in last month	1.5	2.5	3.8	-1.6	-1.8	-0.5	-1.7	-1.9
Alzheimer’s Disease (including proxy)	1.4	2.0	4.0	-1.3	-1.2	-2.0	-1.0	-1.4
Eye problems/disorders: None of the above	1.4	1.7	2.6	1.3	1.3	0.5	1.6	1.5
Medication for pain relief, constipation, heartburn	1.4	2.3	4.3	-1.2	-1.4	-0.9	-1.8	-2.1
Mouth/teeth dental problems: Mouth ulcers	1.4	2.1	2.6	1.4	1.5	1.1	1.6	1.6
Back pain experienced in last month	1.4	2.0	3.1	1.8	1.5	0.3	1.5	1.5
Mineral and other dietary supplements	1.4	1.9	3.6	1.0	1.1	1.0	1.6	1.9
Osteoporosis (self-reported)	1.4	1.8	3.3	-1.1	-1.1	-1.1	-1.4	-1.8
Age started oral contraceptive pill	1.4	1.8	2.7	-1.3	-1.6	-0.5	-1.6	-1.3
Diabetes (mother)	1.3	1.6	2.3	1.4	1.4	0.2	1.5	1.4
Severe depression (siblings)	1.3	1.5	3.2	1.3	1.2	1.8	0.8	0.8
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	3.0	-1.3	-1.4	-1.3	-1.5	-1.7
High blood pressure (siblings)	1.3	1.9	4.5	1.0	1.1	0.6	1.6	2.1
Mouth/teeth dental problems: Loose teeth	1.3	1.5	5.2	-1.2	-0.9	-2.3	-0.5	-0.1
Medication: Omeprazole	1.3	1.6	2.4	1.1	0.9	-1.0	1.5	1.5
Medication: Paracetamol	1.3	2.0	4.1	1.0	1.2	2.0	1.1	1.6
Medication: Metformin	1.2	1.7	2.9	-1.4	-1.1	-0.0	-1.6	-1.7
Prospective memory result	1.2	1.4	2.2	1.3	1.1	0.5	1.4	1.5
Migraine (self-reported)	1.2	1.4	2.1	1.4	1.5	0.6	1.4	1.0
Fractured/broken bones in last 5 years	1.2	1.5	2.5	-1.1	-1.1	-1.1	-1.3	-1.6
Unable to work because of sickness or disability	1.2	1.6	2.9	0.7	0.9	-1.7	1.5	1.2
Vascular/heart problems diagnosed by doctor	1.2	3.3	6.0	-1.5	-1.5	-1.5	-2.0	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.6	0.6	1.0	-0.4	1.4	1.9
High blood pressure	1.1	3.2	5.9	1.4	1.4	1.6	1.8	2.4
Chronic bronchitis/emphysema (father)	1.1	1.3	1.7	-1.1	-1.1	-1.3	-1.2	-1.1
Mouth/teeth dental problems	1.1	1.6	2.9	-1.2	-1.3	-0.6	-1.3	-1.7
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.5	1.0	1.2	0.3	1.6	1.5
Medication: Seretide 50 evohaler	1.1	1.3	1.8	-1.0	-1.1	-0.7	-1.3	-1.3
Average weekly champagne plus white wine intake	1.1	1.4	2.3	1.5	1.3	1.4	0.9	0.7
Ever depressed for a whole week	1.1	1.3	2.1	-1.4	-1.5	-1.1	-1.0	-0.8
Crohns Disease (2017)	1.0	2.1	2.9	1.7	1.6	1.4	1.1	1.4
Coronary Artery Disease (CAD)	1.0	1.2	1.6	1.2	1.2	0.0	1.2	1.3
Fasting Glucose	1.0	1.2	1.5	1.0	1.2	1.1	1.1	1.0
Hair/balding pattern: Pattern 3	1.0	1.5	2.5	1.1	1.3	1.0	1.6	1.1
Medication: Lansoprazole	1.0	1.1	2.5	0.4	0.8	-0.3	1.4	1.6
Knee pain experienced in last month	1.0	1.5	2.8	1.0	1.1	-0.5	1.5	1.7
Hypertension (Self-reported)	1.0	2.7	5.0	1.4	1.3	1.5	1.6	2.2
Diastolic blood pressure, automated reading	1.0	3.0	6.5	-2.1	-1.8	-2.5	-1.0	-0.2
Schizophrenia vs Biploar Disorder	0.9	1.2	1.9	-1.3	-1.4	0.0	-1.2	-0.9
Alzheimer’s Disease (in mother)	0.9	1.0	3.4	-0.7	-0.9	-1.8	-0.3	-0.6
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.4	-1.1	-0.9	0.6	-1.2	-1.1
Qualifications: CSEs or equivalent	0.9	1.3	2.0	0.7	1.1	1.1	1.2	1.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	3.3	-1.3	-1.3	-1.8	-1.0	-1.1
Comparative body size at age 10	0.9	2.4	5.8	-0.4	-0.9	1.0	-2.1	-2.4
Shortness of breath walking on level ground	0.9	1.0	2.0	-1.0	-0.8	-1.4	-0.8	-0.9
Heart disease (mother)	0.9	1.1	1.7	-0.9	-1.0	-0.6	-1.3	-1.3
Pulse rate, automated reading	0.9	2.8	3.4	1.7	1.7	1.9	1.5	1.6
Smoking status: Previous	0.9	1.4	5.4	-1.0	-0.8	-2.3	-0.0	0.1
Commuting to job workplace: Walk	0.9	1.0	1.4	-0.7	-1.0	-1.0	-1.1	-1.2
LDL Cholesterol	0.8	1.2	1.9	1.2	1.4	0.0	1.2	1.1
Primary Biliary Cirrhosis	0.8	1.1	2.5	-0.7	-0.9	0.4	-1.3	-1.6
Past tobacco smoking	0.8	1.5	6.0	0.7	0.4	2.4	-0.5	-0.7
Hair/balding pattern: Pattern 2	0.8	1.0	2.3	-0.9	-1.1	-1.5	-0.8	-0.5
Diabetes (self-reported)	0.8	1.2	2.4	-0.9	-1.0	0.2	-1.3	-1.6
Illnesses of siblings	0.8	1.1	3.1	-0.6	-0.8	0.2	-1.3	-1.8
Father’s age at death	0.8	1.1	2.0	-0.9	-1.0	-0.1	-1.3	-1.4
Happiness	0.8	0.9	2.2	1.1	0.9	1.5	0.3	0.6
Medication: Cholesterol lowering	0.8	1.2	1.4	1.2	1.1	0.8	1.2	1.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.6	-0.8	-0.8	-1.6	-0.5	-0.7
Friendships satisfaction	0.8	0.9	1.3	-1.1	-1.1	-0.9	-1.0	-0.6
Medication: Blood pressure	0.8	1.6	2.3	1.4	1.1	0.7	1.4	1.5
Number of operations (self-reported)	0.8	1.2	1.6	1.1	1.1	1.3	0.9	1.0
Schizophrenia (2018)	0.7	1.4	2.5	-1.6	-1.5	0.0	-1.4	-0.8
Crohns Disease (2012)	0.7	1.2	2.1	1.4	1.3	0.0	1.1	1.0
Rheumatoid Arthritis	0.7	0.9	1.3	1.1	0.9	0.9	0.9	0.9
Ever had hysterectomy (womb removed)	0.7	0.8	1.1	1.1	1.0	0.2	1.0	0.8
Systolic blood pressure, automated reading	0.7	2.0	4.4	-1.7	-1.4	-2.1	-0.7	-0.0
Pack years adult smoking proportion	0.7	1.1	1.5	-1.2	-1.1	-0.5	-1.2	-0.9
Hand grip strength (right)	0.7	1.9	2.4	-1.5	-1.4	-1.1	-1.4	-1.4
Number of incorrect matches in round	0.7	1.1	1.8	1.3	1.3	0.2	1.0	1.0
Pain all over the body in last month	0.7	0.7	1.3	0.6	0.8	0.2	1.1	1.1
Falls in the last year	0.7	1.0	2.5	0.4	0.6	-1.1	0.8	1.6
Length of working week for main job	0.7	0.8	3.9	-0.3	-0.2	-2.0	0.1	0.1
Wears glasses or contact lenses	0.7	0.9	3.8	-0.4	-0.5	-1.9	-0.1	-0.3
Commuting to job workplace: Public transport	0.7	0.8	1.2	1.0	0.6	0.6	1.0	1.1
Eye problems/disorders: Glaucoma	0.7	0.8	1.6	-0.9	-0.7	-1.3	-0.7	-0.9
Medication: Atorvastatin	0.7	0.9	2.0	0.9	1.0	1.4	0.7	0.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.3	0.7	0.6	-1.1	1.0	1.1
Pack years of smoking	0.7	1.0	1.6	-1.1	-1.1	-0.3	-1.2	-0.9
Age at First Birth	0.6	0.8	1.8	0.9	0.8	1.3	0.7	0.6
Medication: Co-codamol	0.6	0.7	3.4	-0.4	-0.4	-1.9	0.1	0.0
Alcohol usually taken with meals	0.6	1.0	1.3	1.1	1.0	1.1	1.0	0.7
Time employed in main current job	0.6	0.7	0.9	-0.9	-1.0	-0.9	-0.8	-0.7
Medication: Ibuprofen	0.6	0.7	2.1	-1.5	-1.0	-0.2	-0.5	-0.1
Comparative height size at age 10	0.6	3.4	6.6	-1.3	-1.6	-0.8	-2.3	-2.6
Had major operations	0.6	0.7	2.6	0.8	0.7	1.6	0.1	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.6	-0.0	0.1	-1.1	0.9	1.3
Diabetes diagnosed by doctor	0.6	1.0	2.4	-0.7	-0.7	0.5	-1.1	-1.6
Illnesses of father: High blood pressure	0.6	0.7	1.8	0.9	0.8	1.3	0.5	0.5
Ever smoked	0.6	1.0	2.0	0.1	0.3	-1.2	1.1	1.4
Average weekly beer plus cider intake	0.6	0.8	1.1	0.9	1.0	1.1	0.8	0.8
Bipolar Disorder or Schizophrenia	0.5	1.2	2.2	-1.5	-1.3	0.0	-1.2	-0.8
Cardiovascular Disease	0.5	1.6	2.9	1.1	1.0	1.7	0.9	1.5
Hypothyroidism (self reported)	0.5	1.1	1.6	-1.1	-1.0	-1.3	-0.9	-1.0
Average weekly fortified wine intake	0.5	0.6	1.0	1.0	1.0	0.6	0.8	0.4
Taking other prescription medications	0.5	0.8	3.5	-0.2	-0.2	-1.9	0.5	0.2
Impedance of leg (left)	0.5	2.3	7.0	0.7	0.9	0.2	1.7	2.7
Had menopause	0.5	0.6	1.3	-0.7	-0.8	-0.2	-1.1	-0.9
Had other major operations	0.5	0.6	1.3	0.5	0.6	-0.4	1.1	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.6	1.0	1.0	0.7	1.3	1.2
Alcohol intake versus 10 years previously	0.5	0.7	1.2	0.6	0.8	-0.7	1.1	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	2.6	1.1	1.3	0.7	1.6	1.6
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.7	0.4	0.8	0.2	0.8	1.3
Qualifications: College or University degree	0.5	1.6	2.1	-1.1	-1.5	-1.2	-1.2	-1.4
Average weekly red wine intake	0.5	0.7	1.5	-0.9	-0.9	-1.2	-0.2	-0.4
Depression (Nagel 2018)	0.4	0.6	1.5	0.3	0.6	-0.5	0.9	1.2
Systolic Blood Pressure	0.4	1.8	5.4	-0.4	-0.1	-1.3	1.4	2.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.9	-0.6	-0.6	0.3	-1.0	-1.4
Hand grip strength (left)	0.4	1.0	1.4	-1.1	-0.9	-1.2	-0.8	-1.1
Relative age of first facial hair	0.4	0.9	1.5	0.5	0.4	-1.1	1.2	1.2
Relative age voice broke	0.4	0.6	1.2	0.8	0.6	-0.3	1.1	0.9
Serious illness, injury or assault to yourself	0.4	0.5	1.4	-0.8	-0.5	-1.2	-0.5	-0.4
Hearing difficulty/problems with background noise	0.4	0.6	1.7	-0.4	-0.4	-1.3	-0.4	-1.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	-0.9	-0.9	-0.7	-0.3	-0.0
Financial difficulties in last 2 years	0.4	0.6	1.1	0.9	1.1	-0.1	0.8	0.4
Asthma	0.4	0.8	1.7	1.3	1.0	1.1	0.3	0.1
Lung cancer (father)	0.4	0.5	0.7	0.8	0.7	0.8	0.6	0.6
Illnesses of mother	0.4	0.5	1.1	-0.6	-0.7	-0.3	-0.9	-1.0
Birth weight of first child	0.4	0.8	1.1	1.0	1.0	0.4	1.1	0.7
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.8	-0.8	-0.9	-0.5	-0.7	-0.1
Blood clot in the leg (DVT)	0.4	0.5	1.7	-0.3	-0.4	-0.5	-0.6	-1.3
Exposure to tobacco smoke outside home	0.4	0.5	1.7	-0.5	-0.5	-1.3	-0.2	0.2
Wheeze or whistling in the chest in last year	0.4	0.8	1.4	1.2	1.1	0.0	0.8	0.9
Number of full sisters	0.4	0.5	1.4	-0.8	-0.5	-1.2	-0.4	-0.4
Overall health rating	0.4	0.9	1.3	1.1	1.2	-0.2	1.0	0.9
Leg pain on walking	0.4	0.4	1.1	-0.2	0.0	-1.0	0.6	0.9
Long-standing illness, disability or infirmity	0.4	0.5	1.8	0.3	0.3	-1.4	0.7	0.5
Eye problems/disorders: Cataract	0.4	0.5	0.9	-0.8	-0.8	0.2	-1.0	-0.4
Asthma (self-reported)	0.4	0.8	1.6	1.3	0.9	1.1	0.3	0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.8	-0.5	-0.6	-1.3	-0.2	-0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	-0.4	-0.6	-0.2	-1.0	-1.0
Alcohol drinker status: Never	0.4	0.5	1.6	0.6	0.5	1.3	0.0	0.1
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	-0.4	-0.4	-0.4	-0.9	-0.9
Schizophrenia (2014)	0.3	0.7	1.3	-1.1	-1.0	0.0	-1.0	-0.5
Blood Red Count	0.3	2.9	11.6	1.0	1.4	3.4	0.1	-0.2
Smoking Status	0.3	0.7	2.0	0.6	0.5	-0.5	1.0	1.4
Respiratory disease	0.3	0.8	2.0	1.1	0.7	1.4	-0.0	-0.2
Hearing difficulty/problems: Yes	0.3	0.5	2.5	-0.3	-0.1	-1.6	0.2	-0.2
Diabetes (father)	0.3	0.4	1.0	-0.4	-0.3	0.2	-0.8	-1.0
Impedance of leg (right)	0.3	1.6	5.7	0.3	0.5	0.1	1.4	2.4
Current tobacco smoking	0.3	0.5	0.8	-0.9	-0.8	-0.1	-0.9	-0.4
Fed-up feelings	0.3	0.5	1.6	-0.3	0.0	-0.8	0.5	1.3
Age when periods started (menarche)	0.3	0.7	1.6	0.6	0.8	0.2	0.8	1.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.4	0.6	0.4	1.2	0.1	-0.1
Arm fat percentage (right)	0.3	1.4	1.8	-1.1	-1.1	-1.4	-1.2	-1.1
Number of live births	0.3	0.4	1.2	-0.4	-0.5	-0.1	-1.1	-0.8
Noisy workplace	0.3	0.4	1.7	-0.4	-0.3	-1.3	-0.0	-0.1
Peak expiratory flow (PEF)	0.3	0.7	0.9	0.9	0.9	0.6	0.8	0.8
Gout (self-reported)	0.3	0.5	0.7	0.7	0.7	-0.1	0.8	0.7
Number of children fathered	0.3	0.4	0.9	-0.5	-0.6	-0.9	-0.3	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	-0.9	-0.4	0.7	-0.6	-0.2
Arm fat percentage (left)	0.3	1.1	1.5	-1.0	-1.0	-1.2	-1.0	-1.0
Qualifications: nursing, teaching	0.3	0.5	1.1	1.1	0.7	0.6	0.7	0.2
Breast cancer (self-reported)	0.3	0.4	0.7	-0.5	-0.6	-0.3	-0.6	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.3	0.8	0.6	0.5	0.9	0.5	0.3
Ever taken oral contraceptive pill	0.3	0.4	1.0	-1.0	-0.9	-0.0	-0.5	-0.1
Hearing aid user	0.3	0.4	0.6	0.8	0.7	0.5	0.5	0.5
Medication: Bendroflumethiazide	0.3	0.5	1.2	0.5	0.4	1.1	0.2	0.8
Risk taking	0.3	0.5	0.6	-0.5	-0.6	-0.8	-0.7	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.3	-0.1	-0.2	-0.3	-0.5	-1.1
Breast Cancer	0.2	0.4	1.3	0.3	0.0	1.2	-0.7	-0.3
Prostate Cancer	0.2	0.3	1.0	0.5	0.5	1.0	0.1	0.4
Bipolar Disorder (2011)	0.2	0.2	0.8	0.3	0.0	0.0	0.0	-0.9
Blood White Count	0.2	1.2	2.8	0.8	1.0	1.7	0.7	1.0
BMI	0.2	1.4	4.0	-0.5	-0.7	-0.4	-1.4	-2.0
Waist Hip Ratio (WHR)	0.2	0.8	1.3	0.7	0.9	1.1	0.8	0.9
Lung FEV1/FVC ratio	0.2	1.2	3.0	0.6	0.8	-0.6	1.2	1.7
Multivitamins +/- minerals	0.2	0.2	0.4	0.6	0.5	0.0	0.0	-0.6
Supplements: Glucosamine	0.2	0.3	0.5	-0.3	-0.3	-0.7	-0.6	-0.6
Medication: Atenolol	0.2	0.2	0.5	-0.4	-0.7	0.1	-0.4	-0.5
Medication: Levothyroxine sodium	0.2	0.4	0.7	-0.8	-0.8	-0.3	-0.7	-0.5
Fluid intelligence score	0.2	0.3	0.6	-0.5	-0.8	0.2	-0.6	-0.6
Impedance of arm (right)	0.2	1.0	1.4	-1.1	-1.2	-1.1	-0.2	0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.7	0.6	0.8	0.1	1.1	1.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.7	-0.7	-0.7	-0.0	-0.7	-0.8
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	0.6	0.4	0.6	0.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	-0.9	-0.4	-0.0	0.1	0.6
Impedance of arm (left)	0.2	0.8	1.2	-1.0	-1.1	-0.9	-0.0	1.1
Arm fat mass (right)	0.2	0.8	1.2	-0.6	-0.7	-1.0	-1.0	-1.1
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.5	0.5	-0.6	0.5	0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	-0.2	-0.3	-0.5	-0.4	-0.6
Number of full brothers	0.2	0.2	0.5	0.3	0.4	-0.7	0.5	0.5
Age at first live birth	0.2	0.3	0.7	-0.6	-0.7	-0.1	-0.4	-0.9
Family relationship satisfaction	0.2	0.3	0.7	-0.7	-0.4	-0.8	-0.4	0.0
Medication: Aspirin	0.2	0.2	0.5	0.6	0.5	0.7	0.2	0.1
Illnesses of father: Heart disease	0.2	0.3	0.7	0.3	0.3	-0.4	0.6	0.8
Medication for cholesterol	0.2	0.3	0.7	0.2	0.5	-0.5	0.8	0.7
Arm fat mass (left)	0.2	0.7	1.1	-0.6	-0.7	-0.9	-0.9	-1.1
Medication: Lisinopril	0.2	0.3	0.7	0.3	0.3	-0.2	0.7	0.9
Basal cell carcinoma (self-reported)	0.2	0.3	1.4	0.0	0.0	1.2	-0.2	-0.1
Heart disease (siblings)	0.2	0.3	0.6	0.2	0.4	-0.5	0.5	0.8
Impedance of whole body	0.2	1.0	4.0	-0.1	-0.1	-0.2	0.9	2.0
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	-0.5	-0.7	-0.2	-0.6	-0.6
Mean Putamen Volume	0.1	0.1	0.1	-0.2	-0.3	-0.4	0.2	0.2
HDL Cholesterol	0.1	0.2	0.4	-0.6	-0.7	0.0	-0.4	-0.3
Blood Eosinophil Count	0.1	0.6	1.1	-1.0	-0.7	-1.1	-0.5	-0.2
Blood Platelet Count	0.1	1.3	2.7	0.7	0.9	0.9	1.2	1.6
Heel T-Score	0.1	0.5	1.1	-0.9	-0.9	-1.1	-0.4	0.0
Height	0.1	1.0	3.8	-0.6	-0.9	-1.9	-0.5	0.2
Lung FVC	0.1	0.5	2.0	-0.6	-0.3	-1.4	0.3	0.1
Tanning	0.1	0.9	2.7	1.0	0.7	1.6	0.1	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	0.0	-0.1	-0.0	-0.6	0.1
Angina	0.1	0.2	0.3	0.3	0.5	0.3	0.4	0.4
Vitamin and mineral supplements	0.1	0.2	0.3	-0.5	-0.4	-0.3	0.1	0.6
Leg fat-free mass (left)	0.1	0.6	1.9	-0.2	-0.3	-0.6	-0.7	-1.4
Trunk fat percentage	0.1	0.3	0.8	-0.3	-0.5	-0.9	-0.3	-0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.1	-0.1	-0.1	-0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	0.5	0.5	0.2	0.7	0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.4	0.4	-0.1	-0.1	-0.0
Body mass index (BMI)	0.1	0.5	1.4	-0.2	-0.3	-0.5	-0.7	-1.2
Leg predicted mass (left)	0.1	0.6	1.9	-0.1	-0.3	-0.5	-0.7	-1.4
Trunk fat mass	0.1	0.3	0.8	-0.2	-0.4	-0.9	-0.5	-0.7
Waist circumference	0.1	0.4	1.3	-0.2	-0.2	-0.0	-0.9	-1.1
Qualifications: None of the above	0.1	0.1	0.4	0.2	0.4	0.1	0.2	0.6
Allergy	0.1	0.2	0.8	-0.3	0.1	0.1	0.4	0.9
Medication: Simvastatin	0.1	0.1	0.2	-0.3	-0.4	-0.3	-0.2	0.0
Weight	0.1	0.4	1.2	-0.1	-0.3	-0.6	-0.7	-1.1
Trunk fat-free mass	0.1	0.4	1.6	0.1	-0.0	-0.0	-0.7	-1.2
Hip circumference	0.1	0.5	1.2	-0.2	-0.4	-0.5	-0.9	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.8	-0.4	-0.2	-0.9	-0.2	-0.3
Pulse rate	0.1	0.1	0.3	0.1	0.2	0.5	-0.4	-0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.4	-0.0	-0.0	-0.1	-0.0	0.6
Trunk predicted mass	0.1	0.5	1.8	0.0	-0.1	-0.1	-0.8	-1.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.8	-0.1	0.1	0.9	0.0	-0.1
Medication: Amlodipine	0.1	0.1	0.4	-0.1	-0.3	-0.0	0.1	0.6
Birth weight	0.1	0.3	0.4	-0.6	-0.6	-0.7	-0.4	0.2
Leg fat percentage (right)	0.1	0.5	1.1	-0.6	-0.5	-1.0	-0.6	-0.7
Arm fat-free mass (right)	0.1	0.3	0.9	0.7	0.6	0.3	-0.1	-0.9
Pulse wave peak to peak time	0.1	0.1	0.4	-0.0	-0.1	0.0	0.1	-0.6
Health satisfaction	0.1	0.1	0.3	-0.5	-0.3	-0.5	-0.1	0.0
Emphysema/chronic bronchitis	0.1	0.1	0.4	0.1	-0.1	-0.6	-0.3	-0.1
Angina (self-reported)	0.1	0.2	0.3	0.4	0.5	0.4	0.3	0.3
Medication: Allopurinol	0.1	0.2	0.4	-0.4	-0.4	-0.2	-0.6	-0.5
Whole body fat mass	0.1	0.3	0.5	-0.1	-0.2	-0.7	-0.5	-0.7
Leg fat mass (right)	0.1	0.3	0.7	-0.2	-0.2	-0.8	-0.4	-0.7
Arm predicted mass (right)	0.1	0.3	1.3	0.4	0.3	0.2	-0.4	-1.1
Alcohol intake frequency.	0.1	0.2	0.4	-0.4	-0.4	-0.6	-0.6	-0.3
Age at last live birth	0.1	0.1	0.3	0.2	0.2	0.1	0.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.6	-0.4	-0.1	-0.4	-0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.5	-0.7	-0.3	0.0	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.5	-0.1	-0.1	-0.7	-0.0	-0.1
Whole body fat-free mass	0.1	0.3	1.4	0.2	0.1	-0.1	-0.5	-1.2
Leg fat-free mass (right)	0.1	0.5	1.8	-0.0	-0.2	-0.5	-0.6	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.2	-0.3	-0.2	0.5	-0.4	-0.5
Medication: Aspirin	0.1	0.1	0.2	0.5	0.4	0.2	0.3	-0.0
Smoking status: Current	0.1	0.2	0.4	-0.5	-0.4	0.0	-0.6	-0.2
Whole body water mass	0.1	0.4	1.5	0.2	0.0	-0.2	-0.6	-1.2
Leg predicted mass (right)	0.1	0.5	2.0	-0.0	-0.2	-0.5	-0.6	-1.4
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.4	-0.4	-0.2	-0.4	-0.2
Basal metabolic rate	0.1	0.4	1.4	0.1	-0.0	-0.4	-0.6	-1.2
Leg fat percentage (left)	0.1	0.4	1.2	-0.4	-0.4	-1.1	-0.4	-0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.4	0.4	-0.2	0.6	0.2
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.1	0.1	0.0	0.0	0.5
Myopia	0.1	0.2	0.2	-0.4	-0.5	-0.4	-0.5	-0.2
Cholesterol lowering medication	0.1	0.2	0.4	-0.1	-0.3	0.7	-0.5	0.0
Alcohol drinker status: Previous	0.1	0.1	0.4	0.1	-0.0	-0.1	0.4	0.6
Leg fat mass (left)	0.1	0.3	0.7	-0.2	-0.2	-0.9	-0.5	-0.8
Arm predicted mass (left)	0.1	0.3	0.9	0.5	0.4	0.1	-0.3	-0.9
Bipolar Disorder (2018)	0.0	0.1	0.2	-0.4	-0.3	0.0	-0.2	-0.2
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.1	-0.4	0.5	-0.4	-0.3
Ovarian Cancer	0.0	0.0	0.0	0.1	-0.1	-0.0	0.0	0.0
Lupus	0.0	0.1	0.2	-0.2	-0.1	0.0	-0.2	-0.4
Triglycerides	0.0	0.1	0.2	0.3	0.4	0.0	0.2	0.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	-0.1	0.3	0.0	0.1	0.2
Allergy or Eczema	0.0	0.1	0.3	0.5	0.2	0.4	-0.1	-0.3
Hair Pigment	0.0	0.7	1.3	0.7	0.9	0.4	1.1	0.8
Number of treatments/medications taken	0.0	0.1	0.1	0.2	0.0	0.2	0.3	0.3
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.1	0.1	0.1	-0.2	-0.2
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.3	0.2	-0.0	-0.1	-0.1	-0.5
Sitting height	0.0	0.1	0.4	-0.1	-0.3	-0.6	-0.3	-0.3
Forced vital capacity (FVC)	0.0	0.2	0.6	-0.2	-0.1	-0.7	0.3	0.5
Heart attack	0.0	0.0	0.1	0.0	-0.0	-0.4	0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	0.2	-0.1	0.2	-0.2	-0.2
Standing height	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.1	-0.0
Pulse wave reflection index	0.0	0.1	0.1	-0.3	-0.1	0.2	-0.3	0.3
Forced vital capacity (FVC), Best measure	0.0	0.2	0.3	0.3	0.4	0.2	0.4	0.6
Body fat percentage	0.0	0.2	0.7	-0.2	-0.3	-0.8	-0.1	-0.1
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.1	0.1	-0.3	0.2	0.2
Chest pain or discomfort	0.0	0.1	0.1	0.2	0.3	0.1	0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.0	-0.2	-0.0	0.1	-0.0	-0.0
Financial situation satisfaction	0.0	0.1	0.1	-0.4	-0.1	-0.3	-0.3	0.1
Arm fat-free mass (left)	0.0	0.2	0.5	0.5	0.5	-0.0	-0.2	-0.7
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	0.1	0.1	-0.3	0.2	-0.2

Hub : Genes

PAX6

Models

Trait associations