Hub : Traits :

Neuroticism score

719 significantly associated models · 132 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 20373107 22200998 2 1 2.6e-08 2.5e-08 1.2e-01 92 EIF4G3
2 1 171053153 172474017 1 1 2.9e-10 3.7e-09 3.7e-03 76 METTL13
3 2 147993969 149475737 1 1 2.7e-11 1.2e-12 9.6e-03 87 ORC4
4 3 16154636 17814553 1 1 5.1e-08 4.8e-09 1.0e+00 100 PLCL2
5 3 48702606 51234774 10 3 4.5e-09 4.6e-09 1.0e+00 100 GPX1 SEMA3B-AS1 U73166.2
6 3 135273949 137261517 3 1 9.1e-10 5.2e-10 1.0e+00 100 RP11-85F14.5
7 5 87104604 88677293 1 1 2.2e-07 6.7e-08 6.1e-03 74 LINC00461
8 5 106500969 108412472 1 1 9.3e-09 1.8e-10 5.3e-05 60 FBXL17
9 7 11553163 12967449 1 1 1.4e-09 2.4e-09 4.6e-01 98 TMEM106B
10 7 125383444 127590914 1 1 2.6e-07 6.0e-11 7.5e-06 53 GRM8
11 7 154388677 155777228 1 1 8.2e-08 4.6e-08 1.0e+00 100 AC144652.1
12 9 95186937 96913764 3 2 2.3e-09 2.9e-09 6.2e-03 79 NINJ1 RP11-165J3.6
13 9 97520168 98975128 1 1 4.5e-08 7.5e-10 4.6e-03 79 PTCH1
14 9 119768572 121177842 1 1 2.7e-08 1.4e-08 9.4e-03 79 TLR4
15 11 12611333 14105497 1 1 6.8e-10 3.3e-09 2.5e-01 96 ARNTL
16 11 46033104 48559571 8 1 8.5e-13 2.0e-10 5.5e-02 91 MADD
17 11 56742853 58178587 2 1 7.7e-12 7.6e-11 1.0e+00 100 ZDHHC5
18 11 112135760 113969669 4 2 2.4e-12 7.1e-16 2.8e-09 46 ANKK1 NCAM1
19 12 108763672 110704487 4 1 1.9e-08 9.7e-10 2.0e-03 74 MYO1H
20 13 67247879 68652684 1 1 9.0e-08 1.8e-08 8.6e-04 65 LINC00364
21 14 69027866 70518587 1 1 1.6e-07 1.9e-08 2.6e-03 71 GALNT16
22 14 74245607 76089054 5 3 5.4e-14 4.2e-12 3.5e-01 98 AREL1 DLST RPS6KL1
23 15 77207277 78806023 1 1 2.6e-07 7.1e-10 4.4e-05 56 LINGO1
24 16 30347731 31758245 4 1 1.7e-08 2.6e-08 3.3e-01 97 RP11-196G11.2
25 16 88030355 89448663 1 1 6.3e-09 5.0e-08 3.3e-03 71 SNAI3-AS1
26 17 1805677 3287175 1 1 1.9e-07 1.8e-09 8.2e-05 57 PAFAH1B1
27 17 42607368 45796313 23 1 1.6e-21 5.6e-20 4.8e-01 99 MAPT
28 18 34124783 35844220 1 1 3.1e-07 8.2e-17 5.4e-13 25 CELF4
29 18 52209411 54028036 1 1 2.1e-09 2.6e-10 1.0e-04 62 TCF4
30 20 32594714 34109427 2 1 1.1e-08 5.4e-07 7.3e-01 100 TP53INP2
31 22 39219932 42614362 5 2 1.2e-08 2.0e-09 1.8e-01 95 ATF4 SLC25A17

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 2.34 1 0 0.0 0.00 1.0e+00 MADD
Crohns Disease (2017) 1.32 1 1 3.0 0.00 1.0e+00 GPX1
Irritable Bowel Disease (IBD) 1.61 1 1 3.0 0.00 1.0e+00 GPX1
Ulcerative Colitis (UC) 1.51 1 1 3.0 0.00 1.0e+00 GPX1
Major Depression (MDD) 4.81 4 0 0.0 -1.00 1.1e-03 GPX1 TCF4 TMEM106B ZDHHC5
Verbal and Numeric Reasoning (VNR) 3.26 7 3 9.1 0.53 2.2e-01 ATF4 GPX1 LINC00461 MAPT METTL13 NCAM1 NINJ1
Breast Cancer 1.44 1 1 3.0 0.00 1.0e+00 MAPT
Ovarian Cancer 1.76 1 1 3.0 0.00 1.0e+00 MAPT
Prostate Cancer 1.63 1 0 0.0 0.00 1.0e+00 GPX1
Age at First Birth 1.72 1 1 3.0 0.00 1.0e+00 GPX1
Body Mass Index (BMI) (2010) 1.83 1 0 0.0 0.00 1.0e+00 MADD
Fasting Glucose 1.73 1 1 3.0 0.00 1.0e+00 MADD
HDL Cholesterol 1.65 1 1 3.0 0.00 1.0e+00 MYO1H
Neuroticism 8.42 9 1 3.0 -0.99 2.0e-07 AREL1 GPX1 LINC00461 MADD MAPT SLC25A17 TCF4 TLR4 U73166.2
Primary Biliary Cirrhosis 1.45 1 0 0.0 0.00 1.0e+00 PLCL2
Schizophrenia 2.46 3 1 3.0 0.00 1.0e+00 RP11-85F14.5 SLC25A17 ZDHHC5
Triglycerides 1.51 1 1 3.0 0.00 1.0e+00 TP53INP2
Ulcerative Colitis 1.62 1 1 3.0 0.00 1.0e+00 GPX1
Blood Eosinophil Count 1.53 7 5 15.2 0.54 2.1e-01 EIF4G3 GPX1 MAPT MYO1H ORC4 PLCL2 SLC25A17
Blood Platelet Count 1.25 12 9 27.3 0.08 8.2e-01 AC144652.1 AREL1 DLST LINC00461 MADD METTL13 NINJ1 RP11-85F14.5 RPS6KL1 SNAI3-AS1 U73166.2 ZDHHC5
Blood Red Count 2.78 8 7 21.2 -0.69 5.8e-02 ARNTL EIF4G3 LINC00461 MAPT METTL13 RP11-196G11.2 SNAI3-AS1 ZDHHC5
Blood White Count 1.00 7 3 9.1 0.04 9.3e-01 GPX1 MADD MAPT MYO1H PTCH1 RP11-85F14.5 SNAI3-AS1
Heel T-Score 1.45 8 3 9.1 -0.13 7.6e-01 AREL1 DLST MADD MAPT NINJ1 RPS6KL1 SLC25A17 ZDHHC5
BMI 2.68 8 6 18.2 -0.16 7.1e-01 ANKK1 ARNTL GALNT16 GPX1 LINC00461 MADD RP11-196G11.2 TLR4
Height 1.48 16 14 42.4 0.28 2.9e-01 AREL1 EIF4G3 GPX1 MADD MAPT METTL13 PAFAH1B1 PTCH1 RP11-165J3.6 RPS6KL1 SEMA3B-AS1 SNAI3-AS1 TCF4 TMEM106B TP53INP2 U73166.2
Waist Hip Ratio (WHR) 1.83 6 4 12.1 -0.27 6.0e-01 EIF4G3 GPX1 MAPT NINJ1 RP11-85F14.5 U73166.2
Systolic Blood Pressure 2.66 8 7 21.2 -0.17 6.9e-01 AREL1 ARNTL GPX1 MADD MAPT PAFAH1B1 RPS6KL1 ZDHHC5
Smoking Status 2.16 1 1 3.0 0.00 1.0e+00 GPX1
Allergy or Eczema 1.24 2 1 3.0 0.00 1.0e+00 PLCL2 SLC25A17
Cardiovascular Disease 1.95 4 1 3.0 0.66 3.4e-01 ARNTL EIF4G3 RP11-196G11.2 RP11-85F14.5
Hypothyroidism (self reported) 1.34 1 0 0.0 0.00 1.0e+00 RPS6KL1
Respiratory disease 1.22 1 0 0.0 0.00 1.0e+00 SNAI3-AS1
Lung FEV1/FVC ratio 1.99 6 4 12.1 0.88 2.0e-02 AREL1 DLST MAPT PTCH1 RPS6KL1 ZDHHC5
Lung FVC 3.36 9 8 24.2 0.28 4.6e-01 GPX1 MAPT PTCH1 RP11-196G11.2 SEMA3B-AS1 SNAI3-AS1 TCF4 TP53INP2 U73166.2
Neuroticism 16.37 38 34 103.0 -0.99 2.3e-37 AC144652.1 ANKK1 AREL1 ARNTL ATF4 CELF4 DLST EIF4G3 FBXL17 GALNT16 GPX1 GRM8 LINC00364 LINC00461 LINGO1 MADD MAPT METTL13 MYO1H NCAM1 NINJ1 ORC4 PAFAH1B1 PLCL2 PTCH1 RP11-165J3.6 RP11-196G11.2 RP11-85F14.5 RPS6KL1 SEMA3B-AS1 SLC25A17 SNAI3-AS1 TCF4 TLR4 TMEM106B TP53INP2 U73166.2 ZDHHC5
Chronotype (morning person) 2.23 2 2 6.1 0.00 1.0e+00 EIF4G3 U73166.2
Hair Pigment 4.06 4 3 9.1 -0.42 5.8e-01 AC144652.1 SLC25A17 SNAI3-AS1 TP53INP2
Tanning 7.55 3 2 6.1 0.00 1.0e+00 AREL1 SNAI3-AS1 TP53INP2
Hand grip strength (left) 2.58 6 4 12.1 -0.03 9.6e-01 AREL1 LINGO1 MADD MAPT RPS6KL1 TCF4
Number of treatments/medications taken 3.90 4 3 9.1 1.00 4.5e-03 AREL1 DLST GPX1 RPS6KL1
Sensitivity / hurt feelings 8.93 12 6 18.2 0.97 7.9e-08 ANKK1 GRM8 MAPT METTL13 MYO1H NCAM1 ORC4 PLCL2 PTCH1 RP11-165J3.6 RP11-85F14.5 ZDHHC5
Frequency of depressed mood in last 2 weeks 7.87 11 2 6.1 0.98 1.5e-07 ANKK1 CELF4 MADD MAPT NCAM1 NINJ1 RP11-165J3.6 RP11-85F14.5 TMEM106B U73166.2 ZDHHC5
Hearing difficulty/problems: Yes 2.35 3 0 0.0 0.00 1.0e+00 FBXL17 MAPT MYO1H
Relative age of first facial hair 2.20 1 1 3.0 0.00 1.0e+00 MAPT
Systolic blood pressure, automated reading 2.46 8 2 6.1 0.08 8.6e-01 AREL1 ARNTL GPX1 MADD MAPT PAFAH1B1 RPS6KL1 ZDHHC5
Pack years adult smoking proportion 2.05 1 0 0.0 0.00 1.0e+00 GPX1
Impedance of leg (right) 2.31 11 6 18.2 0.27 4.3e-01 AREL1 GPX1 LINC00461 MADD MAPT NINJ1 PTCH1 SEMA3B-AS1 SNAI3-AS1 TP53INP2 U73166.2
Leg fat-free mass (left) 1.33 4 3 9.1 0.46 5.4e-01 LINC00461 PTCH1 SNAI3-AS1 TP53INP2
Trunk fat percentage 2.84 12 5 15.2 -0.05 8.9e-01 ANKK1 AREL1 ARNTL GALNT16 GPX1 LINC00461 MADD MAPT RP11-196G11.2 RPS6KL1 SLC25A17 ZDHHC5
Hand grip strength (right) 1.93 4 2 6.1 -0.59 4.1e-01 LINGO1 MADD MAPT TCF4
Current tobacco smoking 1.96 1 0 0.0 0.00 1.0e+00 SLC25A17
Fed-up feelings 8.69 17 7 21.2 0.98 1.3e-12 AC144652.1 AREL1 ARNTL DLST GALNT16 GPX1 LINC00461 LINGO1 MADD MAPT NCAM1 ORC4 PAFAH1B1 RP11-85F14.5 RPS6KL1 TLR4 ZDHHC5
Frequency of unenthusiasm / disinterest in last 2 weeks 6.97 7 1 3.0 0.99 1.0e-05 ANKK1 CELF4 EIF4G3 GALNT16 RP11-85F14.5 U73166.2 ZDHHC5
Relative age voice broke 1.94 1 1 3.0 0.00 1.0e+00 MAPT
Taking other prescription medications 4.06 4 2 6.1 1.00 2.2e-03 AREL1 DLST GPX1 RPS6KL1
Age when periods started (menarche) 2.26 4 3 9.1 0.97 3.4e-02 ARNTL GPX1 MADD MAPT
Heel bone mineral density (BMD) T-score, automated (left) 1.24 1 0 0.0 0.00 1.0e+00 MAPT
High blood pressure 1.71 4 1 3.0 -0.06 9.4e-01 ARNTL EIF4G3 MADD MAPT
Sitting height 2.13 6 6 18.2 -0.14 7.9e-01 MADD MAPT PTCH1 SNAI3-AS1 TP53INP2 ZDHHC5
Body mass index (BMI) 2.59 6 5 15.2 -0.31 5.5e-01 ARNTL GALNT16 GPX1 LINC00461 MADD RP11-196G11.2
Impedance of leg (left) 2.34 10 7 21.2 0.30 4.0e-01 AREL1 GPX1 LINC00461 MADD MAPT NINJ1 SEMA3B-AS1 SNAI3-AS1 TP53INP2 U73166.2
Leg predicted mass (left) 1.35 4 3 9.1 0.45 5.5e-01 LINC00461 PTCH1 SNAI3-AS1 TP53INP2
Trunk fat mass 2.31 8 3 9.1 -0.04 9.3e-01 ANKK1 ARNTL GALNT16 GPX1 LINC00461 MADD MAPT RP11-196G11.2
Waist circumference 2.01 5 3 9.1 -0.08 9.0e-01 ANKK1 ARNTL LINC00461 MADD RP11-196G11.2
Number of incorrect matches in round 1.86 1 0 0.0 0.00 1.0e+00 EIF4G3
Alcohol usually taken with meals 2.29 1 0 0.0 0.00 1.0e+00 ZDHHC5
Nervous feelings 9.04 18 7 21.2 0.99 1.2e-14 ANKK1 AREL1 ARNTL CELF4 DLST EIF4G3 LINC00364 MADD MAPT MYO1H ORC4 RP11-196G11.2 RP11-85F14.5 RPS6KL1 SEMA3B-AS1 SLC25A17 TP53INP2 U73166.2
Frequency of tenseness / restlessness in last 2 weeks 6.87 8 1 3.0 0.99 5.2e-07 CELF4 GPX1 MADD MAPT RP11-165J3.6 RP11-85F14.5 TMEM106B TP53INP2
Hearing difficulty/problems with background noise 2.52 2 1 3.0 0.00 1.0e+00 MAPT PAFAH1B1
Hair/balding pattern: Pattern 2 1.51 1 0 0.0 0.00 1.0e+00 MAPT
Had menopause 1.36 1 0 0.0 0.00 1.0e+00 SEMA3B-AS1
Forced vital capacity (FVC) 2.79 5 5 15.2 -0.23 7.0e-01 GPX1 MAPT PTCH1 RP11-196G11.2 SNAI3-AS1
Heel bone mineral density (BMD) T-score, automated (right) 1.35 1 0 0.0 0.00 1.0e+00 MAPT
Ever unenthusiastic/disinterested for a whole week 3.42 1 0 0.0 0.00 1.0e+00 MAPT
Qualifications: None of the above 2.53 2 1 3.0 0.00 1.0e+00 GALNT16 GPX1
Mouth/teeth dental problems 1.99 2 0 0.0 0.00 1.0e+00 MAPT MYO1H
Fluid intelligence score 2.53 4 0 0.0 -0.68 3.2e-01 GPX1 MADD MAPT METTL13
Weight 1.53 6 3 9.1 0.54 2.7e-01 ANKK1 GPX1 LINC00461 MADD RP11-196G11.2 TP53INP2
Impedance of arm (right) 2.12 8 4 12.1 -0.09 8.3e-01 GPX1 LINC00461 MAPT SEMA3B-AS1 TMEM106B TP53INP2 U73166.2 ZDHHC5
Arm fat percentage (right) 2.84 7 6 18.2 -0.01 9.9e-01 ANKK1 ARNTL GPX1 LINC00461 MADD RP11-196G11.2 ZDHHC5
Trunk fat-free mass 1.18 3 2 6.1 0.00 1.0e+00 PTCH1 RPS6KL1 TP53INP2
Hip circumference 1.96 5 4 12.1 -0.26 6.7e-01 GPX1 LINC00461 MADD PTCH1 RP11-196G11.2
Father's age at death 1.86 1 0 0.0 0.00 1.0e+00 GPX1
Worrier / anxious feelings 10.03 19 12 36.4 0.98 6.7e-14 AREL1 ARNTL DLST LINGO1 MAPT METTL13 MYO1H ORC4 PTCH1 RP11-165J3.6 RP11-196G11.2 RP11-85F14.5 RPS6KL1 SEMA3B-AS1 SLC25A17 TCF4 TLR4 U73166.2 ZDHHC5
Frequency of tiredness / lethargy in last 2 weeks 6.65 8 3 9.1 0.99 4.6e-06 AC144652.1 GALNT16 GPX1 MYO1H PAFAH1B1 RP11-165J3.6 SNAI3-AS1 ZDHHC5
Falls in the last year 2.32 1 1 3.0 0.00 1.0e+00 SEMA3B-AS1
Hair/balding pattern: Pattern 3 2.28 1 1 3.0 0.00 1.0e+00 MAPT
Number of live births 0.89 1 0 0.0 0.00 1.0e+00 MAPT
Forced expiratory volume in 1-second (FEV1) 2.76 5 5 15.2 -0.39 5.2e-01 GPX1 MAPT PTCH1 RP11-196G11.2 SNAI3-AS1
Noisy workplace 1.75 1 0 0.0 0.00 1.0e+00 MAPT
Qualifications: A levels/AS levels or equivalent 2.93 5 1 3.0 -0.69 2.0e-01 GPX1 LINC00461 MAPT METTL13 NINJ1
Mouth/teeth dental problems: Dentures 1.93 2 0 0.0 0.00 1.0e+00 GPX1 TP53INP2
Medication: Ibuprofen (e.g. Nurofen) 1.97 1 0 0.0 0.00 1.0e+00 MAPT
Depression (self-reported) 3.12 1 0 0.0 0.00 1.0e+00 TMEM106B
Medication: Lansoprazole 2.25 1 0 0.0 0.00 1.0e+00 GALNT16
Forced expiratory volume in 1-second (FEV1), Best measure 2.65 5 4 12.1 -0.41 4.9e-01 GPX1 MAPT PTCH1 RP11-196G11.2 SNAI3-AS1
Impedance of arm (left) 2.03 6 4 12.1 -0.05 9.2e-01 GPX1 MAPT SEMA3B-AS1 TP53INP2 U73166.2 ZDHHC5
Arm fat mass (right) 2.38 6 5 15.2 0.03 9.6e-01 ANKK1 ARNTL GPX1 LINC00461 MADD RP11-196G11.2
Trunk predicted mass 1.18 3 2 6.1 0.00 1.0e+00 PTCH1 RPS6KL1 TP53INP2
Standing height 1.47 13 11 33.3 -0.39 1.9e-01 EIF4G3 GPX1 MADD MAPT METTL13 PAFAH1B1 PTCH1 RP11-165J3.6 RPS6KL1 SEMA3B-AS1 SNAI3-AS1 TMEM106B TP53INP2
Tense / 'highly strung' 8.15 14 5 15.2 0.98 2.0e-09 AC144652.1 ANKK1 AREL1 MAPT NINJ1 ORC4 RP11-165J3.6 RP11-196G11.2 RP11-85F14.5 SEMA3B-AS1 SLC25A17 TMEM106B TP53INP2 U73166.2
Seen doctor (GP) for nerves, anxiety, tension or depression 5.65 5 2 6.1 0.97 5.1e-03 ANKK1 AREL1 GPX1 TCF4 TMEM106B
Hair/balding pattern: Pattern 4 2.97 1 1 3.0 0.00 1.0e+00 MAPT
Birth weight of first child 1.59 1 0 0.0 0.00 1.0e+00 PAFAH1B1
Peak expiratory flow (PEF) 1.52 1 1 3.0 0.00 1.0e+00 MAPT
Qualifications: O levels/GCSEs or equivalent 2.32 3 1 3.0 0.00 1.0e+00 GPX1 LINC00461 PLCL2
Mouth/teeth dental problems: Bleeding gums 1.62 1 0 0.0 0.00 1.0e+00 MYO1H
Medication: Paracetamol 3.25 2 2 6.1 0.00 1.0e+00 GPX1 MAPT
Headache pain in last month 3.34 3 1 3.0 0.00 1.0e+00 MAPT TLR4 ZDHHC5
Birth weight 1.22 1 1 3.0 0.00 1.0e+00 PTCH1
Forced vital capacity (FVC), Best measure 2.77 5 5 15.2 -0.26 6.7e-01 GPX1 MAPT PTCH1 RP11-196G11.2 SNAI3-AS1
Body fat percentage 2.95 10 5 15.2 0.07 8.4e-01 ANKK1 AREL1 ARNTL GALNT16 GPX1 LINC00461 MADD RP11-196G11.2 RPS6KL1 ZDHHC5
Leg fat percentage (right) 3.12 9 7 21.2 0.21 5.9e-01 ANKK1 AREL1 ARNTL GALNT16 GPX1 LINC00461 MADD RP11-196G11.2 RPS6KL1
Arm fat-free mass (right) 1.23 4 2 6.1 -1.00 1.5e-03 GPX1 LINC00461 PTCH1 TP53INP2
Comparative body size at age 10 3.01 6 4 12.1 -0.78 6.7e-02 LINC00461 MADD NINJ1 RP11-165J3.6 RP11-196G11.2 U73166.2
Worry too long after embarrassment 8.27 12 5 15.2 0.97 1.8e-07 ANKK1 ARNTL ATF4 EIF4G3 FBXL17 LINC00461 MAPT MYO1H NCAM1 RP11-85F14.5 TP53INP2 ZDHHC5
Seen a psychiatrist for nerves, anxiety, tension or depression 3.96 1 0 0.0 0.00 1.0e+00 TMEM106B
Wheeze or whistling in the chest in last year 2.43 3 0 0.0 0.00 1.0e+00 GPX1 RP11-165J3.6 SNAI3-AS1
Age at first live birth 2.15 1 1 3.0 0.00 1.0e+00 GPX1
Qualifications: College or University degree 3.12 7 4 12.1 -0.68 9.1e-02 CELF4 GALNT16 GPX1 LINC00461 MAPT NINJ1 ZDHHC5
Medication for pain relief, constipation, heartburn 3.15 5 1 3.0 -0.99 4.5e-04 AREL1 GPX1 MAPT RP11-165J3.6 RPS6KL1
Neck or shoulder pain in last month 1.75 1 0 0.0 0.00 1.0e+00 GPX1
Whole body fat mass 2.38 7 4 12.1 0.08 8.6e-01 ANKK1 ARNTL GALNT16 GPX1 LINC00461 MADD RP11-196G11.2
Leg fat mass (right) 2.49 7 5 15.2 0.13 7.8e-01 ANKK1 ARNTL GALNT16 GPX1 LINC00461 MADD RP11-196G11.2
Arm predicted mass (right) 1.20 4 1 3.0 -1.00 2.3e-03 GPX1 LINC00461 PTCH1 TP53INP2
Pulse rate, automated reading 1.70 2 0 0.0 0.00 1.0e+00 LINC00461 ZDHHC5
Alcohol intake frequency. 3.07 6 3 9.1 0.64 1.7e-01 GALNT16 LINC00364 MADD MAPT TCF4 ZDHHC5
Comparative height size at age 10 1.47 7 4 12.1 -0.47 2.8e-01 DLST GPX1 MAPT METTL13 PTCH1 RPS6KL1 TCF4
Suffer from 'nerves' 7.09 7 2 6.1 0.96 7.1e-04 ANKK1 AREL1 DLST EIF4G3 MADD MAPT RPS6KL1
Overall health rating 4.66 6 2 6.1 0.97 1.6e-03 ANKK1 GALNT16 GPX1 NCAM1 NINJ1 RP11-165J3.6
Chest pain or discomfort 2.27 1 0 0.0 0.00 1.0e+00 AC144652.1
Age at last live birth 1.92 1 1 3.0 0.00 1.0e+00 GPX1
Knee pain experienced in last month 1.96 1 0 0.0 0.00 1.0e+00 TP53INP2
Hypertension (Self-reported) 1.66 4 0 0.0 -0.06 9.4e-01 ARNTL EIF4G3 MADD MAPT
Forced expiratory volume in 1-second (FEV1), predicted 1.42 1 0 0.0 0.00 1.0e+00 PTCH1
Whole body fat-free mass 1.19 3 2 6.1 0.00 1.0e+00 LINC00461 PTCH1 TP53INP2
Leg fat-free mass (right) 1.40 4 3 9.1 0.20 8.0e-01 LINC00461 PTCH1 SNAI3-AS1 TP53INP2
Arm fat percentage (left) 2.90 7 5 15.2 -0.04 9.3e-01 ANKK1 ARNTL GPX1 LINC00461 MADD RP11-196G11.2 ZDHHC5
Average weekly red wine intake 2.18 1 1 3.0 0.00 1.0e+00 ZDHHC5
Handedness (chirality/laterality): Left-handed 1.76 1 1 3.0 0.00 1.0e+00 MAPT
Mood swings 11.48 18 10 30.3 0.98 2.4e-13 ANKK1 AREL1 DLST GALNT16 GPX1 MADD MAPT METTL13 NCAM1 NINJ1 PLCL2 RP11-165J3.6 RPS6KL1 SLC25A17 SNAI3-AS1 TCF4 TLR4 TMEM106B
Loneliness, isolation 6.76 6 2 6.1 0.98 4.6e-04 GPX1 MADD MAPT ORC4 RP11-85F14.5 TMEM106B
Qualifications: nursing, teaching 2.55 1 0 0.0 0.00 1.0e+00 GALNT16
Mouth/teeth dental problems: Mouth ulcers 1.57 1 1 3.0 0.00 1.0e+00 MAPT
Medication for cholesterol 2.06 1 0 0.0 0.00 1.0e+00 MAPT
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.05 2 2 6.1 0.00 1.0e+00 MAPT RP11-196G11.2
Whole body water mass 1.19 4 2 6.1 -0.79 2.1e-01 GPX1 LINC00461 PTCH1 TP53INP2
Leg predicted mass (right) 1.40 4 3 9.1 0.17 8.3e-01 LINC00461 PTCH1 SNAI3-AS1 TP53INP2
Arm fat mass (left) 2.37 6 5 15.2 0.00 1.0e+00 ANKK1 ARNTL GPX1 LINC00461 MADD RP11-196G11.2
Number of self-reported non-cancer illnesses 3.33 4 0 0.0 0.08 9.2e-01 AREL1 ARNTL EIF4G3 TMEM106B
Average weekly champagne plus white wine intake 1.26 1 0 0.0 0.00 1.0e+00 MAPT
Miserableness 9.51 15 9 27.3 0.97 7.2e-10 ANKK1 ARNTL GPX1 LINGO1 MADD MAPT METTL13 NCAM1 ORC4 PAFAH1B1 RP11-165J3.6 RP11-85F14.5 SNAI3-AS1 TCF4 TMEM106B
Guilty feelings 9.61 14 7 21.2 0.99 1.1e-10 ANKK1 AREL1 ARNTL ATF4 DLST LINGO1 MADD MAPT METTL13 NCAM1 PAFAH1B1 PTCH1 RPS6KL1 ZDHHC5
Financial situation satisfaction 2.99 1 1 3.0 0.00 1.0e+00 GPX1
Medication: Blood pressure 1.85 1 1 3.0 0.00 1.0e+00 MAPT
High cholesterol (Self-reported) 1.48 1 0 0.0 0.00 1.0e+00 RP11-196G11.2
Medication: Bendroflumethiazide 1.79 1 0 0.0 0.00 1.0e+00 SNAI3-AS1
Medication: Paracetamol 3.04 2 2 6.1 0.00 1.0e+00 GPX1 MAPT
Illnesses of father: High blood pressure 1.70 1 0 0.0 0.00 1.0e+00 MADD
Basal metabolic rate 1.19 4 3 9.1 -0.80 2.0e-01 GPX1 LINC00461 PTCH1 TP53INP2
Leg fat percentage (left) 3.17 9 7 21.2 0.18 6.4e-01 ANKK1 AREL1 ARNTL GALNT16 GPX1 LINC00461 MADD RP11-196G11.2 RPS6KL1
Arm fat-free mass (left) 1.17 4 2 6.1 -0.94 6.5e-02 GPX1 LINC00461 PTCH1 TP53INP2
Number of operations (self-reported) 2.10 1 0 0.0 0.00 1.0e+00 GPX1
Irritability 8.30 15 6 18.2 0.98 2.8e-10 ANKK1 AREL1 FBXL17 GPX1 LINC00461 MAPT ORC4 PAFAH1B1 RP11-196G11.2 SLC25A17 SNAI3-AS1 TCF4 TLR4 TMEM106B TP53INP2
Risk taking 1.91 1 0 0.0 0.00 1.0e+00 RP11-85F14.5
Ever had prostate specific antigen (PSA) test 1.41 1 0 0.0 0.00 1.0e+00 PAFAH1B1
Fractured/broken bones in last 5 years 1.66 1 0 0.0 0.00 1.0e+00 SEMA3B-AS1
Diastolic blood pressure, automated reading 1.76 5 2 6.1 0.57 3.1e-01 ARNTL GPX1 LINC00461 MADD PAFAH1B1
Ever depressed for a whole week 2.43 1 0 0.0 0.00 1.0e+00 MAPT
Vascular/heart problems diagnosed by doctor 1.75 3 0 0.0 0.00 1.0e+00 ARNTL EIF4G3 MADD
Cholesterol lowering medication 1.49 1 0 0.0 0.00 1.0e+00 RP11-196G11.2
Pain experienced in last month 3.52 2 1 3.0 0.00 1.0e+00 GPX1 MAPT
Basal cell carcinoma (self-reported) 1.89 1 1 3.0 0.00 1.0e+00 TP53INP2
Alcohol drinker status: Previous 2.38 1 0 0.0 0.00 1.0e+00 ATF4
Pack years of smoking 1.99 1 0 0.0 0.00 1.0e+00 GPX1
Impedance of whole body 2.09 7 6 18.2 -0.02 9.7e-01 AREL1 GPX1 LINC00461 MAPT SEMA3B-AS1 TP53INP2 U73166.2
Leg fat mass (left) 2.53 7 5 15.2 0.11 8.1e-01 ANKK1 ARNTL GALNT16 GPX1 LINC00461 MADD RP11-196G11.2
Arm predicted mass (left) 1.20 4 3 9.1 -0.98 2.0e-02 GPX1 LINC00461 PTCH1 TP53INP2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 17 0.487 2.03
GTEx Adipose Visceral Omentum 11 0.540 2.24
GTEx Adrenal Gland 12 0.824 2.23
GTEx Artery Aorta 20 0.672 2.21
GTEx Artery Coronary 14 1.183 2.56
GTEx Artery Tibial 16 0.425 2.03
GTEx Brain Caudate basal ganglia 10 1.087 2.45
GTEx Brain Cerebellar Hemisphere 11 0.739 2.31
GTEx Brain Cerebellum 13 0.656 2.15
GTEx Brain Cortex 11 1.063 2.62
GTEx Brain Frontal Cortex BA9 8 0.866 2.47
GTEx Brain Hippocampus 4 0.763 2.53
GTEx Brain Hypothalamus 5 0.847 2.39
GTEx Brain Nucleus accumbens basal ganglia 7 0.809 2.35
GTEx Brain Putamen basal ganglia 6 0.962 2.44
GTEx Breast Mammary Tissue 15 0.760 2.22
GTEx Breast Mammary Tissue (Male) 10 0.838 2.26
GTEx Breast Mammary Tissue (Female) 15 0.912 2.24
GTEx Cells EBV-transformed lymphocytes 13 0.914 2.52
GTEx Cells Transformed fibroblasts 20 0.476 2.04
GTEx Colon Sigmoid 11 0.752 2.31
GTEx Colon Transverse 19 0.921 2.31
GTEx Esophagus Gastroesophageal Junction 14 0.969 2.52
GTEx Esophagus Mucosa 21 0.633 2.11
GTEx Esophagus Muscularis 21 0.650 2.31
GTEx Heart Atrial Appendage 14 0.887 2.37
GTEx Heart Left Ventricle 13 0.850 2.35
GTEx Liver 7 0.976 2.27
GTEx Lung 21 0.731 2.24
GTEx Muscle Skeletal 20 0.692 2.13
GTEx Nerve Tibial 19 0.440 2.06
GTEx Ovary 10 1.101 2.53
GTEx Pancreas 14 0.858 2.33
GTEx Pituitary 10 0.897 2.28
GTEx Prostate 6 0.719 2.38
GTEx Skin Not Sun Exposed Suprapubic 18 0.732 2.34
GTEx Skin Sun Exposed Lower leg 23 0.632 2.26
GTEx Small Intestine Terminal Ileum 7 1.518 2.76
GTEx Spleen 14 0.992 2.43
GTEx Stomach 12 0.825 2.36
GTEx Testis 25 0.792 2.24
GTEx Thyroid 23 0.575 2.13
GTEx Uterus 11 1.940 2.89
GTEx Vagina 7 1.102 2.56
GTEx Whole Blood 11 0.552 2.09
METSIM Adipose 9 0.195 1.81
NTR Blood 10 0.416 2.01
ROSMAP Brain Pre-frontal Cortex 28 0.638 2.17
YFS Blood 10 0.217 1.79
CommonMind Brain Pre-frontal Cortex 16 0.298 1.92
TCGA Breast Tumor 5 0.652 1.98
TCGA Breast Normal 5 0.119 1.73
TCGA Ovarian Tumor 18 0.616 2.01
TCGA Prostate Tumor 9 0.260 1.90