Hub : Traits :

Hypothyroidism/myxoedema (self-reported)

432 significantly associated models · 143 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 18940380 20503710 2 1 2.2e-09 3.5e-10 7.0e-07 38 CAPZB
2 1 23431777 24861704 1 1 1.9e-07 6.0e-07 2.2e-01 94 HMGCL
3 1 107418424 109188382 1 1 2.6e-36 1.6e-36 1.0e+00 100 VAV3
4 1 113236087 115222434 9 11 3.8e-54 3.5e-124 NaN NaN AP4B1 AP4B1-AS1 DCLRE1B HIPK1 OLFML3 PHTF1 PTPN22
5 1 156078249 157482371 1 1 1.5e-07 4.9e-08 1.3e-01 92 SH2D2A
6 2 159836227 161259685 1 1 2.2e-07 4.1e-07 1.0e+00 100 AC009961.3
7 2 190521054 192712723 7 3 9.3e-11 7.7e-29 1.2e-17 41 MFSD6 NAB1 STAT4
8 2 241563169 243048760 2 2 2.6e-07 4.9e-07 5.7e-02 86 AC114730.7 SEPT2
9 3 11350553 12928762 2 1 1.4e-08 7.7e-08 4.5e-01 98 TIMP4
10 3 36339386 38174470 3 1 4.4e-09 1.2e-08 5.7e-02 89 LRRFIP2
11 3 168789705 170185994 1 1 9.3e-09 5.8e-06 2.0e-01 92 ARPM1
12 4 122961964 124352460 1 1 2.7e-07 3.4e-08 3.3e-02 85 BBS12
13 4 148303195 150060844 1 1 6.1e-21 2.5e-21 1.0e+00 100 NR3C2
14 5 71557313 73083183 1 1 2.1e-07 9.8e-07 8.9e-05 36 FCHO2
15 5 75812681 77412011 1 1 1.1e-07 2.1e-09 5.2e-03 78 PDE8B
16 5 101392473 103061825 1 1 1.7e-09 1.2e-09 9.8e-02 93 PAM
17 6 25296606 26689223 1 1 6.5e-09 9.6e-12 1.2e-06 49 U91328.19
18 6 89666956 91704536 2 2 7.0e-27 4.0e-29 3.4e-06 83 BACH2 MDN1
19 6 134905567 136727603 3 1 2.1e-09 1.7e-09 2.6e-03 75 AHI1
20 6 166651581 167841508 4 1 6.8e-25 3.9e-24 1.0e+00 100 RNASET2
21 7 99591418 100979310 1 1 5.7e-10 1.5e-09 1.0e+00 100 GIGYF1
22 8 8092025 13066409 27 1 4.1e-16 1.6e-18 1.0e+00 100 SGK223
23 8 60736025 62220903 1 1 2.6e-08 3.9e-08 1.0e+00 100 RAB2A
24 8 133023595 134846363 3 1 1.5e-09 2.5e-12 7.3e-05 68 TG
25 9 99581811 101652673 6 6 2.6e-50 2.1e-71 NaN NaN C9orf156 CORO2A TMOD1
26 10 4999536 6677767 3 2 1.8e-15 2.9e-15 6.2e-02 94 FAM208B FBXO18
27 10 16986810 18453209 1 1 8.4e-08 6.0e-07 1.0e+00 100 STAM
28 10 63253359 64724096 1 1 4.9e-10 5.8e-19 7.7e-18 6 RTKN2
29 10 123438113 124889817 1 1 3.7e-09 2.8e-09 1.0e+00 100 PLEKHA1
30 11 60839578 62326265 3 1 8.7e-08 1.4e-07 4.3e-01 98 FADS2
31 11 85317186 86755322 1 1 3.4e-07 1.8e-05 7.6e-01 100 C11orf73
32 12 55601472 57125879 6 1 1.4e-13 2.0e-11 8.0e-02 93 SUOX
33 12 109641978 113517494 20 7 8.5e-48 1.1e-81 NaN NaN ADAM1A ALDH2 HECTD4 RP3-462E2.3 VPS29
34 15 38088200 39556796 1 1 6.1e-10 4.4e-12 5.3e-04 75 RASGRP1
35 16 49650937 51097687 1 1 1.1e-07 3.8e-07 3.0e-01 96 BRD7
36 16 66773300 68536105 3 1 7.9e-08 4.3e-08 1.9e-01 94 ATP6V0D1
37 17 6190353 7949434 2 1 2.1e-07 1.7e-11 2.3e-06 51 RP11-589P10.7
38 17 39570442 41265776 3 1 3.8e-12 3.1e-12 1.0e+00 100 RAB5C
39 17 44788310 46602432 5 3 1.8e-13 5.4e-13 1.7e-04 73 EFCAB13 MRPL10 NPEPPS
40 18 66371289 68204223 1 1 6.3e-09 1.8e-09 1.0e+00 100 DOK6
41 19 4118871 5529588 1 1 2.5e-09 7.2e-15 4.8e-07 58 TICAM1
42 19 17672385 19190906 2 1 3.8e-08 7.6e-10 1.0e-04 60 KIAA1683
43 19 49279612 50909389 2 3 1.3e-10 1.7e-10 1.0e+00 100 ALDH16A1 CPT1C
44 22 36867133 38292974 2 2 1.8e-17 8.8e-22 9.6e-07 74 C1QTNF6
45 22 39064209 40479448 1 1 2.4e-07 2.8e-07 1.0e+00 100 SYNGR1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 2.92 9 3 9.1 -0.33 3.3e-01 AP4B1-AS1 CPT1C DCLRE1B FADS2 GIGYF1 HIPK1 RASGRP1 RNASET2 SYNGR1
Irritable Bowel Disease (IBD) 2.24 6 2 6.1 0.78 6.9e-02 BBS12 BRD7 CPT1C HECTD4 RNASET2 SYNGR1
Ulcerative Colitis (UC) 1.51 2 0 0.0 0.00 1.0e+00 BBS12 SYNGR1
Reaction Time 1.86 3 2 6.1 -0.97 3.1e-02 ALDH2 HECTD4 RP3-462E2.3
Verbal and Numeric Reasoning (VNR) 1.36 4 0 0.0 0.38 6.2e-01 ALDH16A1 FADS2 PAM SUOX
Breast Cancer 1.50 3 1 3.0 0.90 9.9e-02 AP4B1 DCLRE1B PHTF1
Coronary Artery Disease (CAD) 2.08 2 0 0.0 0.00 1.0e+00 HECTD4 VPS29
Crohns Disease (2012) 2.22 5 1 3.0 0.04 9.5e-01 DCLRE1B FADS2 HIPK1 RASGRP1 RNASET2
Fasting Glucose 1.42 1 0 0.0 0.00 1.0e+00 FADS2
HbA1C 1.14 1 0 0.0 0.00 1.0e+00 ADAM1A
HDL Cholesterol 1.69 1 1 3.0 0.00 1.0e+00 FADS2
LDL Cholesterol 2.42 3 2 6.1 -0.84 1.6e-01 ALDH2 FADS2 HECTD4
Lupus 3.99 7 1 3.0 -0.72 3.0e-02 AHI1 DCLRE1B HECTD4 MFSD6 NAB1 RTKN2 SGK223
Neuroticism 1.42 1 1 3.0 0.00 1.0e+00 SGK223
Primary Biliary Cirrhosis 2.89 4 1 3.0 -0.80 1.0e-01 DOK6 HECTD4 NAB1 SYNGR1
Rheumatoid Arthritis 11.84 13 8 24.2 -0.96 1.4e-09 AP4B1 AP4B1-AS1 DCLRE1B FAM208B HECTD4 HIPK1 NAB1 OLFML3 PAM PHTF1 PTPN22 RASGRP1 SYNGR1
Schizophrenia 1.14 2 0 0.0 0.00 1.0e+00 GIGYF1 SGK223
Triglycerides 1.71 1 1 3.0 0.00 1.0e+00 FADS2
Ulcerative Colitis 1.60 2 0 0.0 0.00 1.0e+00 BBS12 BRD7
Blood Eosinophil Count 10.10 26 21 63.6 -0.64 2.4e-04 AC114730.7 ADAM1A ALDH2 ARPM1 BACH2 BBS12 DOK6 EFCAB13 FADS2 FAM208B FBXO18 FCHO2 GIGYF1 HECTD4 HMGCL KIAA1683 MDN1 NAB1 NPEPPS RASGRP1 RP3-462E2.3 SEPT2 STAT4 SUOX TIMP4 VPS29
Blood Platelet Count 5.52 17 10 30.3 -0.44 3.9e-02 ADAM1A C1QTNF6 C9orf156 CAPZB CORO2A DOK6 FADS2 FCHO2 HECTD4 MRPL10 NAB1 PAM RP3-462E2.3 SH2D2A SYNGR1 TIMP4 VPS29
Blood Red Count 2.49 20 13 39.4 -0.36 1.1e-01 ADAM1A ALDH2 ATP6V0D1 BACH2 C9orf156 CPT1C FADS2 GIGYF1 HECTD4 HMGCL MDN1 MFSD6 NAB1 NPEPPS PAM RP3-462E2.3 SEPT2 SUOX TG VPS29
Blood White Count 4.91 22 17 51.5 -0.48 1.4e-02 AC009961.3 ADAM1A AHI1 ALDH2 AP4B1 ATP6V0D1 BACH2 DCLRE1B DOK6 FADS2 HECTD4 OLFML3 PAM PDE8B PHTF1 RAB2A RAB5C RP11-589P10.7 RP3-462E2.3 SEPT2 TIMP4 VPS29
Heel T-Score 0.79 6 4 12.1 -0.34 5.2e-01 ATP6V0D1 BACH2 CAPZB FADS2 FCHO2 NAB1
BMI 0.73 3 1 3.0 0.99 1.2e-02 HECTD4 SUOX VPS29
Height 0.98 22 16 48.5 0.35 7.7e-02 ADAM1A ALDH16A1 ALDH2 ATP6V0D1 C9orf156 CAPZB CPT1C EFCAB13 FADS2 HECTD4 LRRFIP2 NAB1 NPEPPS NR3C2 PAM PLEKHA1 RAB5C RP3-462E2.3 SEPT2 SYNGR1 TG TMOD1
Waist Hip Ratio (WHR) 1.61 8 5 15.2 -0.28 5.0e-01 ADAM1A ATP6V0D1 BACH2 BBS12 KIAA1683 PAM SYNGR1 TIMP4
Systolic Blood Pressure 1.98 8 7 21.2 -0.68 4.2e-02 ADAM1A ALDH2 HECTD4 HMGCL MFSD6 NAB1 RP3-462E2.3 VPS29
Smoking Status 1.13 3 1 3.0 0.00 1.0e+00 ADAM1A DCLRE1B SUOX
Allergy or Eczema 2.96 9 8 24.2 0.10 7.7e-01 AC114730.7 ADAM1A AHI1 BACH2 BBS12 FBXO18 HECTD4 MDN1 SUOX
Cardiovascular Disease 1.78 5 3 9.1 -0.78 6.8e-02 ADAM1A ALDH2 HECTD4 SUOX VPS29
Hypothyroidism (self reported) 32.50 64 60 181.8 -1.00 4.1e-75 AC009961.3 AC114730.7 ADAM1A AHI1 ALDH16A1 ALDH2 AP4B1 AP4B1-AS1 ARPM1 ATP6V0D1 BACH2 BBS12 BRD7 C11orf73 C1QTNF6 C9orf156 CAPZB CORO2A CPT1C DCLRE1B DOK6 EFCAB13 FADS2 FAM208B FBXO18 FCHO2 GIGYF1 HECTD4 HIPK1 HMGCL KIAA1683 LRRFIP2 MDN1 MFSD6 MRPL10 NAB1 NPEPPS NR3C2 OLFML3 PAM PDE8B PHTF1 PLEKHA1 PTPN22 RAB2A RAB5C RASGRP1 RNASET2 RP11-589P10.7 RP3-462E2.3 RTKN2 SEPT2 SGK223 SH2D2A STAM STAT4 SUOX SYNGR1 TG TICAM1 TIMP4 TMOD1 VAV3 VPS29
Respiratory disease 2.92 8 5 15.2 -0.36 3.9e-01 AC114730.7 AHI1 BACH2 BBS12 FADS2 FAM208B FBXO18 SUOX
Type 2 Diabetes (T2D) 1.37 2 0 0.0 0.00 1.0e+00 ADAM1A PAM
Lung FEV1/FVC ratio 1.31 7 6 18.2 0.44 3.2e-01 AC009961.3 ATP6V0D1 C9orf156 KIAA1683 PLEKHA1 SEPT2 SUOX
Lung FVC 1.19 11 3 9.1 -0.30 3.4e-01 AHI1 AP4B1 HECTD4 KIAA1683 MFSD6 PAM PDE8B PLEKHA1 RAB5C RP3-462E2.3 SUOX
Neuroticism 1.13 1 0 0.0 0.00 1.0e+00 TIMP4
Chronotype (morning person) 1.10 3 0 0.0 0.00 1.0e+00 ALDH2 HECTD4 TIMP4
Hair Pigment 0.68 11 8 24.2 -0.21 4.5e-01 ALDH2 C9orf156 CORO2A EFCAB13 FADS2 GIGYF1 HECTD4 MRPL10 RP3-462E2.3 SUOX SYNGR1
Tanning 0.26 5 0 0.0 -0.61 2.0e-01 ALDH2 HECTD4 KIAA1683 RP3-462E2.3 SYNGR1
Number of treatments/medications taken 2.83 7 1 3.0 0.96 4.2e-05 ADAM1A DCLRE1B FADS2 FAM208B HECTD4 PTPN22 RNASET2
Sensitivity / hurt feelings 1.36 1 1 3.0 0.00 1.0e+00 SGK223
Frequency of depressed mood in last 2 weeks 1.17 1 0 0.0 0.00 1.0e+00 RAB5C
Relative age of first facial hair 0.91 1 0 0.0 0.00 1.0e+00 MRPL10
Systolic blood pressure, automated reading 1.45 5 3 9.1 0.18 7.4e-01 ALDH2 HECTD4 MFSD6 NAB1 SGK223
Vitamin and mineral supplements 1.08 1 0 0.0 0.00 1.0e+00 U91328.19
Impedance of leg (right) 1.18 6 3 9.1 0.31 5.5e-01 ATP6V0D1 FCHO2 KIAA1683 PAM SGK223 SUOX
Leg fat-free mass (left) 1.34 9 6 18.2 -0.35 3.2e-01 EFCAB13 HECTD4 PLEKHA1 SEPT2 SGK223 SUOX SYNGR1 U91328.19 VPS29
Trunk fat percentage 1.12 3 3 9.1 0.00 1.0e+00 KIAA1683 LRRFIP2 U91328.19
Hand grip strength (right) 0.67 1 0 0.0 0.00 1.0e+00 SEPT2
Fed-up feelings 1.55 3 1 3.0 -0.54 4.6e-01 ALDH2 HECTD4 SGK223
Relative age voice broke 0.77 1 0 0.0 0.00 1.0e+00 ADAM1A
Taking other prescription medications 4.55 7 4 12.1 0.97 1.6e-05 ADAM1A DCLRE1B FAM208B HECTD4 HIPK1 RAB5C RNASET2
Age when periods started (menarche) 1.10 2 0 0.0 0.00 1.0e+00 DCLRE1B SUOX
Heel bone mineral density (BMD) T-score, automated (left) 1.45 3 1 3.0 0.00 1.0e+00 FADS2 SGK223 U91328.19
High blood pressure 1.79 6 3 9.1 0.16 7.3e-01 ADAM1A ALDH2 HECTD4 RTKN2 SGK223 SUOX
Hayfever, allergic rhinitis or eczema 2.94 9 5 15.2 -0.10 8.0e-01 AC114730.7 ADAM1A AHI1 BACH2 BBS12 FBXO18 HECTD4 SUOX U91328.19
Medication: Atenolol 2.24 1 1 3.0 0.00 1.0e+00 HECTD4
Medication: Levothyroxine sodium 24.92 61 41 124.2 1.00 4.9e-74 AC009961.3 ADAM1A AHI1 ALDH16A1 ALDH2 AP4B1 AP4B1-AS1 ARPM1 ATP6V0D1 BACH2 BRD7 C1QTNF6 C9orf156 CAPZB CORO2A CPT1C DCLRE1B DOK6 EFCAB13 FADS2 FAM208B FBXO18 FCHO2 GIGYF1 HECTD4 HIPK1 KIAA1683 LRRFIP2 MDN1 MFSD6 MRPL10 NAB1 NPEPPS NR3C2 OLFML3 PAM PDE8B PHTF1 PLEKHA1 PTPN22 RAB2A RAB5C RASGRP1 RNASET2 RP11-589P10.7 RP3-462E2.3 RTKN2 SEPT2 SGK223 SH2D2A STAM STAT4 SUOX SYNGR1 TG TICAM1 TIMP4 TMOD1 U91328.19 VAV3 VPS29
Sitting height 0.76 6 3 9.1 -0.05 9.1e-01 C9orf156 CAPZB FADS2 PLEKHA1 SEPT2 U91328.19
Body mass index (BMI) 1.18 5 2 6.1 -0.60 2.9e-01 HECTD4 SGK223 SUOX U91328.19 VPS29
Impedance of leg (left) 1.10 5 3 9.1 0.71 1.8e-01 ATP6V0D1 KIAA1683 PAM SGK223 SUOX
Leg predicted mass (left) 1.34 9 6 18.2 -0.34 3.3e-01 EFCAB13 HECTD4 PLEKHA1 SEPT2 SGK223 SUOX SYNGR1 U91328.19 VPS29
Trunk fat mass 1.28 5 2 6.1 0.76 1.3e-01 KIAA1683 LRRFIP2 PLEKHA1 SYNGR1 U91328.19
Waist circumference 1.09 3 2 6.1 0.00 1.0e+00 HECTD4 KIAA1683 U91328.19
Past tobacco smoking 1.55 5 0 0.0 -0.23 7.1e-01 ADAM1A ALDH2 DCLRE1B HECTD4 SUOX
Nervous feelings 1.33 2 2 6.1 0.00 1.0e+00 SGK223 U91328.19
Hearing difficulty/problems with background noise 1.16 1 0 0.0 0.00 1.0e+00 U91328.19
Forced vital capacity (FVC) 0.97 3 1 3.0 0.00 1.0e+00 ATP6V0D1 PLEKHA1 SEPT2
Heel bone mineral density (BMD) T-score, automated (right) 1.56 4 1 3.0 -0.50 5.0e-01 CAPZB FADS2 SGK223 U91328.19
Ever unenthusiastic/disinterested for a whole week 1.37 1 0 0.0 0.00 1.0e+00 TIMP4
Qualifications: None of the above 1.13 1 0 0.0 0.00 1.0e+00 SUOX
Allergy 2.75 9 5 15.2 -0.10 8.1e-01 AC114730.7 ADAM1A AHI1 BACH2 BBS12 FADS2 FBXO18 SUOX U91328.19
Diabetes (self-reported) 1.40 1 0 0.0 0.00 1.0e+00 DCLRE1B
Hayfever/allergic rhinitis (self-reported) 2.63 3 1 3.0 0.00 1.0e+00 AC114730.7 SUOX U91328.19
Medication: Ramipril 1.34 1 0 0.0 0.00 1.0e+00 ADAM1A
Medication: Simvastatin 1.09 1 0 0.0 0.00 1.0e+00 FADS2
Fluid intelligence score 1.02 1 0 0.0 0.00 1.0e+00 FADS2
Illnesses of siblings 1.34 2 0 0.0 0.00 1.0e+00 ADAM1A HECTD4
Neuroticism score 1.79 3 1 3.0 0.00 1.0e+00 SGK223 TIMP4 U91328.19
Weight 1.50 9 6 18.2 -0.31 3.8e-01 HECTD4 LRRFIP2 PLEKHA1 SEPT2 SGK223 SUOX SYNGR1 U91328.19 VPS29
Impedance of arm (right) 1.47 10 5 15.2 0.54 1.0e-01 ADAM1A AHI1 BBS12 HECTD4 KIAA1683 NR3C2 RTKN2 SGK223 SUOX VPS29
Arm fat percentage (right) 0.90 4 2 6.1 -0.02 9.8e-01 KIAA1683 LRRFIP2 SGK223 U91328.19
Trunk fat-free mass 1.39 11 5 15.2 -0.49 1.1e-01 ADAM1A ALDH2 HECTD4 KIAA1683 PLEKHA1 RP3-462E2.3 SEPT2 SUOX SYNGR1 U91328.19 VPS29
Hip circumference 1.56 10 4 12.1 -0.40 2.2e-01 ALDH2 EFCAB13 HECTD4 PLEKHA1 RP3-462E2.3 SEPT2 SGK223 SYNGR1 U91328.19 VPS29
Father's age at death 1.45 1 0 0.0 0.00 1.0e+00 HECTD4
Worrier / anxious feelings 1.55 2 1 3.0 0.00 1.0e+00 PAM SGK223
Hair/balding pattern: Pattern 3 1.15 1 0 0.0 0.00 1.0e+00 MRPL10
Number of live births 1.36 1 0 0.0 0.00 1.0e+00 FADS2
Forced expiratory volume in 1-second (FEV1) 1.00 3 0 0.0 0.00 1.0e+00 PDE8B SGK223 SUOX
Pulse rate 1.90 3 2 6.1 0.00 1.0e+00 FADS2 GIGYF1 MFSD6
Qualifications: A levels/AS levels or equivalent 1.13 1 0 0.0 0.00 1.0e+00 SUOX
Mouth/teeth dental problems: Dentures 1.36 2 1 3.0 0.00 1.0e+00 SGK223 U91328.19
Asthma 2.76 7 4 12.1 0.32 4.9e-01 AC114730.7 AHI1 BACH2 BBS12 FADS2 FBXO18 SUOX
Medication: Ibuprofen (e.g. Nurofen) 1.55 1 0 0.0 0.00 1.0e+00 HECTD4
Forced expiratory volume in 1-second (FEV1), Best measure 0.84 2 0 0.0 0.00 1.0e+00 SGK223 SUOX
Pulse wave Arterial Stiffness index 1.63 1 1 3.0 0.00 1.0e+00 ADAM1A
Impedance of arm (left) 1.40 10 5 15.2 0.61 4.7e-02 ADAM1A AHI1 BBS12 HECTD4 KIAA1683 NR3C2 RP3-462E2.3 SGK223 SUOX VPS29
Arm fat mass (right) 1.19 6 2 6.1 -0.19 7.2e-01 HECTD4 LRRFIP2 SGK223 SUOX SYNGR1 U91328.19
Trunk predicted mass 1.41 11 6 18.2 -0.49 1.1e-01 ADAM1A ALDH2 HECTD4 KIAA1683 PLEKHA1 RP3-462E2.3 SEPT2 SUOX SYNGR1 U91328.19 VPS29
Standing height 1.06 14 9 27.3 -0.13 6.2e-01 ATP6V0D1 C9orf156 CAPZB EFCAB13 FADS2 HECTD4 NAB1 NPEPPS PLEKHA1 RAB5C SEPT2 SGK223 SYNGR1 U91328.19
Tense / 'highly strung' 1.46 2 1 3.0 0.00 1.0e+00 SGK223 TIMP4
Hair/balding pattern: Pattern 4 1.11 2 1 3.0 0.00 1.0e+00 ATP6V0D1 FADS2
Birth weight of first child 2.37 7 2 6.1 -0.52 1.9e-01 ADAM1A ALDH2 FCHO2 HECTD4 RAB2A RP3-462E2.3 SUOX
Peak expiratory flow (PEF) 0.95 2 1 3.0 0.00 1.0e+00 MFSD6 SGK223
Headache pain in last month 1.50 1 0 0.0 0.00 1.0e+00 U91328.19
Medication for cholesterol, blood pressure or diabetes 1.40 1 0 0.0 0.00 1.0e+00 ADAM1A
Gout (self-reported) 1.17 1 0 0.0 0.00 1.0e+00 HECTD4
Medication: Ventolin 100micrograms inhaler 1.81 3 0 0.0 0.00 1.0e+00 AC114730.7 BACH2 STAM
Birth weight 2.23 6 2 6.1 -0.65 1.1e-01 ADAM1A ALDH2 HECTD4 PLEKHA1 SUOX VPS29
High blood pressure (siblings) 1.42 1 0 0.0 0.00 1.0e+00 HECTD4
Forced vital capacity (FVC), Best measure 0.80 2 1 3.0 0.00 1.0e+00 PLEKHA1 SEPT2
Body fat percentage 1.10 3 3 9.1 0.00 1.0e+00 KIAA1683 LRRFIP2 U91328.19
Leg fat percentage (right) 1.23 3 1 3.0 0.00 1.0e+00 KIAA1683 SGK223 U91328.19
Arm fat-free mass (right) 1.56 10 6 18.2 -0.57 7.0e-02 ADAM1A HECTD4 PLEKHA1 RP3-462E2.3 SEPT2 SGK223 SUOX SYNGR1 U91328.19 VPS29
Comparative body size at age 10 0.98 2 1 3.0 0.00 1.0e+00 SGK223 U91328.19
Worry too long after embarrassment 1.60 1 1 3.0 0.00 1.0e+00 SGK223
Seen a psychiatrist for nerves, anxiety, tension or depression 1.59 2 1 3.0 0.00 1.0e+00 TIMP4 U91328.19
Wheeze or whistling in the chest in last year 1.34 2 1 3.0 0.00 1.0e+00 AC114730.7 FADS2
Reason for reducing amount of alcohol drunk: Health precaution 1.39 1 0 0.0 0.00 1.0e+00 SUOX
Pulse wave peak to peak time 1.57 1 1 3.0 0.00 1.0e+00 ADAM1A
Qualifications: College or University degree 1.01 4 1 3.0 -0.16 8.4e-01 KIAA1683 PAM SUOX U91328.19
Neck or shoulder pain in last month 1.18 1 0 0.0 0.00 1.0e+00 SUOX
Medication: Blood pressure 1.51 3 1 3.0 0.91 8.8e-02 ADAM1A ALDH2 HECTD4
Medication: Seretide 50 evohaler 1.29 1 0 0.0 0.00 1.0e+00 AC114730.7
Mean time to correctly identify matches 1.70 3 2 6.1 0.97 2.9e-02 ALDH2 HECTD4 RP3-462E2.3
Whole body fat mass 1.27 8 1 3.0 -0.08 8.6e-01 HECTD4 KIAA1683 LRRFIP2 PLEKHA1 SGK223 SYNGR1 U91328.19 VPS29
Leg fat mass (right) 1.34 4 2 6.1 -0.59 3.0e-01 HECTD4 SGK223 U91328.19 VPS29
Arm predicted mass (right) 1.59 10 9 27.3 -0.56 7.1e-02 ADAM1A HECTD4 PLEKHA1 RP3-462E2.3 SEPT2 SGK223 SUOX SYNGR1 U91328.19 VPS29
Pulse rate, automated reading 2.46 6 3 9.1 -0.56 2.5e-01 FADS2 GIGYF1 KIAA1683 MFSD6 NAB1 VPS29
Alcohol intake frequency. 1.03 2 0 0.0 0.00 1.0e+00 NPEPPS SUOX
Comparative height size at age 10 1.38 9 5 15.2 -0.78 1.8e-03 ALDH2 ATP6V0D1 C9orf156 CAPZB HECTD4 NR3C2 PDE8B PLEKHA1 SEPT2
Suffer from 'nerves' 1.42 1 0 0.0 0.00 1.0e+00 SGK223
Overall health rating 1.30 3 0 0.0 0.00 1.0e+00 DCLRE1B SGK223 SUOX
Qualifications: NVQ or HND or HNC or equivalent 1.33 1 0 0.0 0.00 1.0e+00 ALDH2
Supplements: Vitamin C 1.15 1 0 0.0 0.00 1.0e+00 U91328.19
Hypertension (Self-reported) 1.65 6 3 9.1 0.13 7.9e-01 ADAM1A ALDH2 HECTD4 RTKN2 SGK223 SUOX
Illnesses of father: Heart disease 1.78 1 0 0.0 0.00 1.0e+00 HECTD4
Smoking status: Previous 1.58 3 0 0.0 0.83 1.7e-01 ALDH2 HECTD4 SUOX
Whole body fat-free mass 1.42 11 5 15.2 -0.46 1.3e-01 ADAM1A EFCAB13 HECTD4 PLEKHA1 RP3-462E2.3 SEPT2 SGK223 SUOX SYNGR1 U91328.19 VPS29
Leg fat-free mass (right) 1.37 9 6 18.2 -0.35 3.2e-01 EFCAB13 HECTD4 PLEKHA1 SEPT2 SGK223 SUOX SYNGR1 U91328.19 VPS29
Arm fat percentage (left) 0.91 4 2 6.1 -0.01 9.9e-01 KIAA1683 LRRFIP2 SGK223 U91328.19
Mood swings 1.14 1 1 3.0 0.00 1.0e+00 SGK223
Loneliness, isolation 1.38 1 0 0.0 0.00 1.0e+00 RNASET2
Long-standing illness, disability or infirmity 2.91 4 1 3.0 0.97 6.9e-03 DCLRE1B FAM208B RASGRP1 RNASET2
Diabetes diagnosed by doctor 1.52 1 0 0.0 0.00 1.0e+00 DCLRE1B
Friendships satisfaction 1.48 1 0 0.0 0.00 1.0e+00 VPS29
Mouth/teeth dental problems: Mouth ulcers 1.91 2 0 0.0 0.00 1.0e+00 BRD7 PAM
Medication for cholesterol 1.60 1 0 0.0 0.00 1.0e+00 HECTD4
Mineral and other dietary supplements 1.10 1 0 0.0 0.00 1.0e+00 SGK223
Asthma (self-reported) 2.86 7 4 12.1 0.32 4.9e-01 AC114730.7 AHI1 BACH2 BBS12 FADS2 FBXO18 SUOX
Medication: Gliclazide 1.12 1 0 0.0 0.00 1.0e+00 LRRFIP2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.06 1 1 3.0 0.00 1.0e+00 U91328.19
Whole body water mass 1.43 11 6 18.2 -0.47 1.2e-01 ADAM1A EFCAB13 HECTD4 PLEKHA1 RP3-462E2.3 SEPT2 SGK223 SUOX SYNGR1 U91328.19 VPS29
Leg predicted mass (right) 1.36 9 6 18.2 -0.35 3.2e-01 EFCAB13 HECTD4 PLEKHA1 SEPT2 SGK223 SUOX SYNGR1 U91328.19 VPS29
Arm fat mass (left) 1.17 5 2 6.1 -0.01 9.8e-01 HECTD4 LRRFIP2 SGK223 SYNGR1 U91328.19
Number of self-reported non-cancer illnesses 2.71 5 1 3.0 0.98 6.9e-04 ALDH2 FAM208B HECTD4 RASGRP1 RNASET2
Average weekly champagne plus white wine intake 1.25 2 1 3.0 0.00 1.0e+00 FADS2 SUOX
Miserableness 1.32 1 1 3.0 0.00 1.0e+00 SGK223
Guilty feelings 1.27 1 0 0.0 0.00 1.0e+00 SGK223
Medication: Blood pressure 1.79 4 2 6.1 0.09 8.8e-01 ALDH2 ARPM1 HECTD4 SGK223
Supplements: Fish oil (including cod liver oil) 1.13 1 0 0.0 0.00 1.0e+00 SGK223
High cholesterol (Self-reported) 1.35 1 0 0.0 0.00 1.0e+00 FADS2
Medication: Bendroflumethiazide 1.34 1 0 0.0 0.00 1.0e+00 SGK223
Medication: Lisinopril 1.42 1 0 0.0 0.00 1.0e+00 HECTD4
Ever smoked 1.33 2 0 0.0 0.00 1.0e+00 DCLRE1B HECTD4
Basal metabolic rate 1.46 11 6 18.2 -0.46 1.4e-01 ADAM1A EFCAB13 HECTD4 PLEKHA1 RP3-462E2.3 SEPT2 SGK223 SUOX SYNGR1 U91328.19 VPS29
Leg fat percentage (left) 1.21 3 1 3.0 0.00 1.0e+00 KIAA1683 SGK223 U91328.19
Arm fat-free mass (left) 1.58 11 8 24.2 -0.61 3.6e-02 ADAM1A ALDH2 HECTD4 PLEKHA1 RP3-462E2.3 SEPT2 SGK223 SUOX SYNGR1 U91328.19 VPS29
Number of operations (self-reported) 1.20 1 0 0.0 0.00 1.0e+00 ARPM1
Average weekly beer plus cider intake 1.22 1 0 0.0 0.00 1.0e+00 SGK223
Irritability 1.65 3 1 3.0 0.00 1.0e+00 FADS2 FCHO2 SGK223
Diastolic blood pressure, automated reading 2.84 8 7 21.2 0.61 6.3e-02 ADAM1A ALDH2 GIGYF1 HECTD4 MFSD6 RP3-462E2.3 SGK223 VPS29
Myopia 1.50 1 0 0.0 0.00 1.0e+00 FADS2
Vascular/heart problems diagnosed by doctor 1.75 7 4 12.1 -0.39 3.5e-01 ADAM1A ALDH2 HECTD4 RTKN2 SGK223 SUOX VPS29
Pain experienced in last month 1.21 2 0 0.0 0.00 1.0e+00 HECTD4 SUOX
Impedance of whole body 1.29 10 4 12.1 0.65 4.4e-02 ADAM1A ARPM1 ATP6V0D1 BBS12 HECTD4 KIAA1683 RTKN2 SGK223 SUOX VPS29
Leg fat mass (left) 1.35 5 2 6.1 -0.33 5.2e-01 HECTD4 LRRFIP2 SGK223 U91328.19 VPS29
Arm predicted mass (left) 1.59 11 7 21.2 -0.61 3.6e-02 ADAM1A ALDH2 HECTD4 PLEKHA1 RP3-462E2.3 SEPT2 SGK223 SUOX SYNGR1 U91328.19 VPS29

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 9 0.258 1.93
GTEx Adipose Visceral Omentum 4 0.196 1.90
GTEx Adrenal Gland 5 0.343 2.05
GTEx Artery Aorta 8 0.269 1.92
GTEx Artery Coronary 4 0.338 1.98
GTEx Artery Tibial 14 0.372 1.99
GTEx Brain Caudate basal ganglia 1 0.109 1.96
GTEx Brain Cerebellar Hemisphere 8 0.537 2.12
GTEx Brain Cerebellum 7 0.353 2.12
GTEx Brain Cortex 4 0.386 1.97
GTEx Brain Frontal Cortex BA9 4 0.433 2.15
GTEx Brain Hippocampus 1 0.191 1.83
GTEx Brain Hypothalamus 1 0.169 1.84
GTEx Brain Nucleus accumbens basal ganglia 4 0.462 1.93
GTEx Brain Putamen basal ganglia 2 0.321 2.27
GTEx Breast Mammary Tissue 6 0.304 1.97
GTEx Breast Mammary Tissue (Male) 3 0.251 1.93
GTEx Breast Mammary Tissue (Female) 5 0.304 1.92
GTEx Cells EBV-transformed lymphocytes 5 0.351 2.00
GTEx Cells Transformed fibroblasts 20 0.476 1.93
GTEx Colon Sigmoid 6 0.410 2.02
GTEx Colon Transverse 10 0.484 2.01
GTEx Esophagus Gastroesophageal Junction 9 0.623 1.99
GTEx Esophagus Mucosa 9 0.271 1.88
GTEx Esophagus Muscularis 10 0.309 1.90
GTEx Heart Atrial Appendage 4 0.253 1.95
GTEx Heart Left Ventricle 2 0.131 1.90
GTEx Liver 1 0.139 1.89
GTEx Lung 10 0.348 1.96
GTEx Muscle Skeletal 14 0.484 1.92
GTEx Nerve Tibial 18 0.417 2.01
GTEx Ovary 7 0.771 2.18
GTEx Pancreas 5 0.306 1.96
GTEx Pituitary 6 0.538 1.97
GTEx Prostate 3 0.359 2.02
GTEx Skin Not Sun Exposed Suprapubic 8 0.325 2.06
GTEx Skin Sun Exposed Lower leg 12 0.330 1.98
GTEx Small Intestine Terminal Ileum 1 0.217 2.12
GTEx Spleen 4 0.283 1.92
GTEx Stomach 7 0.481 2.07
GTEx Testis 13 0.412 2.04
GTEx Thyroid 18 0.450 2.06
GTEx Uterus 2 0.353 2.08
GTEx Vagina 2 0.315 2.05
GTEx Whole Blood 10 0.502 2.28
METSIM Adipose 15 0.325 1.88
NTR Blood 14 0.583 2.25
ROSMAP Brain Pre-frontal Cortex 18 0.410 1.90
YFS Blood 17 0.368 2.05
CommonMind Brain Pre-frontal Cortex 21 0.391 1.89
TCGA Breast Tumor 6 0.782 2.00
TCGA Breast Normal 12 0.285 1.86
TCGA Ovarian Tumor 14 0.479 1.84
TCGA Prostate Tumor 9 0.260 1.93