TWAS hub - SH2D2A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1280	0.0480	0.00440	0.049	NA	0.025	NA	0.030	0.00014	NA	0.00490	NA	0.0023
2	TCGA	Breast Invasive Carcinoma	0.0175	0.0118	0.00290	0.010	0.009	0.010	NA	0.011	0.00340	0.00480	0.00250	NA	0.0021
3	TCGA	Lung Adenocarcinoma	0.0406	0.0220	0.00027	0.022	0.028	0.024	NA	0.022	0.00110	0.00026	0.00069	NA	0.0011

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Hypothyroidism/myxoedema (self-reported)	12.1	23.6	27.6	-5.2	-4.3	-5.0
Medication: Levothyroxine sodium	11.7	19.9	23.6	-4.8	-3.6	-4.9
Hypothyroidism (self reported)	10.3	23.7	28.9	-5.4	-4.2	-5.0
Ever had hysterectomy (womb removed)	6.8	7.7	13.2	2.5	3.6	1.9
Prostate Cancer	6.6	9.2	10.6	2.9	3.0	3.3
Blood Platelet Count	6.2	72.4	83.4	8.6	7.8	9.1
Headache pain in last month	5.6	9.6	13.2	-2.7	-2.9	-3.6
Breastfed as a baby	5.3	6.6	7.3	-2.5	-2.7	-2.4
Hayfever, allergic rhinitis or eczema	5.2	11.3	12.8	-3.4	-3.1	-3.6
Allergy	5.0	11.6	13.8	3.6	2.8	3.7
Allergy or Eczema	4.8	12.7	13.4	-3.7	-3.6	-3.4
Pain experienced in last month	4.8	8.0	13.9	2.3	3.7	2.2
Bilateral oophorectomy (both ovaries removed)	4.7	5.4	6.9	2.6	2.5	1.8
Supplements: Zinc	4.6	5.0	6.6	-2.6	-1.7	-2.3
Age at First Birth	4.5	6.5	8.5	-2.8	-1.8	-2.9
Hearing difficulty/problems: Yes	4.5	6.8	8.0	-2.6	-2.4	-2.8
Alcohol usually taken with meals	4.4	7.1	9.5	-3.0	-1.6	-3.1
Average weekly beer plus cider intake	4.4	6.3	7.6	2.8	2.4	2.4
Taking other prescription medications	4.1	6.3	6.8	-2.6	-2.5	-2.4
Migraine (self-reported)	4.1	5.1	6.0	-2.0	-2.4	-2.4
Supplements: Calcium	4.0	4.4	5.9	-1.9	-2.4	-1.9
Had major operations	3.8	4.5	5.3	-1.8	-2.2	-2.3
Mouth/teeth dental problems: Dentures	3.7	6.2	8.5	2.4	2.1	2.9
Glaucoma (self-reported)	3.7	4.3	5.7	2.3	1.3	2.4
Medication: Gliclazide	3.6	4.0	4.2	2.0	1.9	2.0
Shortness of breath walking on level ground	3.5	4.2	4.7	-2.2	-1.9	-2.1
Commuting to job workplace: Car/motor vehicle	3.5	4.0	5.7	-2.1	-1.4	-2.4
Rheumatoid Arthritis	3.4	4.7	6.6	-2.6	-2.5	-1.3
Chronotype (morning person)	3.4	7.8	10.8	2.8	3.3	2.2
Eye problems/disorders: Glaucoma	3.3	3.9	5.5	2.0	1.5	2.3
Number of treatments/medications taken	3.2	5.7	8.5	-2.2	-2.9	-2.0
Illnesses of siblings	3.2	4.6	5.6	2.1	1.9	2.4
Medication: Lansoprazole	3.2	3.7	5.3	2.0	1.4	2.3
Exposure to tobacco smoke outside home	3.2	4.3	5.4	2.3	1.9	2.0
Tinnitus: Yes, now most or all of the time	3.0	3.5	4.0	-2.0	-1.8	-1.8
Lung cancer (father)	2.9	3.4	4.6	2.1	1.7	1.7
Supplements: Glucosamine	2.7	3.5	4.5	-1.8	-1.7	-2.1
Pain type(s) experienced in last month: Hip pain	2.6	3.3	4.5	-1.9	-2.1	-1.3
Health satisfaction	2.5	3.3	4.2	-2.1	-1.3	-2.0
Long-standing illness, disability or infirmity	2.5	3.8	5.2	-1.6	-1.9	-2.3
Risk taking	2.5	3.7	5.3	-2.3	-1.5	-1.8
Age at first live birth	2.4	4.2	4.7	-2.1	-2.2	-1.9
Medication for cholesterol	2.4	3.7	6.4	2.0	0.9	2.5
Fractured/broken bones in last 5 years	2.4	3.1	6.0	-1.3	-2.5	-1.2
Alzheimer’s Disease (including proxy)	2.3	3.3	4.5	-2.1	-1.9	-1.4
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	3.7	-1.8	-1.8	-1.9
Qualifications: None of the above	2.2	4.8	5.2	2.2	2.3	2.1
High blood pressure (siblings)	2.2	3.1	4.6	-1.8	-1.3	-2.2
Lupus	2.0	3.0	3.5	-1.9	-1.8	-1.5
Serious illness, injury or assault to yourself	2.0	2.5	3.5	-1.5	-1.9	-1.2
Ever taken oral contraceptive pill	1.9	2.1	4.3	-1.1	-2.1	-0.9
HDL Cholesterol	1.8	2.9	4.0	-1.5	-1.6	-2.0
Illnesses of father: Heart disease	1.8	2.5	4.3	-1.6	-2.1	-0.9
Hearing aid user	1.8	2.0	3.4	-1.5	-0.5	-1.8
Triglycerides	1.7	2.7	3.7	1.6	1.9	1.4
Systolic blood pressure, automated reading	1.7	5.0	7.9	2.0	1.7	2.8
Qualifications: CSEs or equivalent	1.7	2.2	2.3	1.5	1.5	1.5
Worrier / anxious feelings	1.7	3.2	3.8	1.9	1.8	1.6
Back pain experienced in last month	1.7	2.5	4.9	-1.5	-2.2	-0.7
Number of self-reported non-cancer illnesses	1.7	3.0	4.2	-1.4	-1.7	-2.0
Unable to work because of sickness or disability	1.7	2.2	2.8	1.7	1.6	1.0
Alzheimer’s Disease (in mother)	1.6	1.8	2.5	-1.6	-1.6	-0.8
Ulcerative Colitis (UC)	1.6	3.1	3.8	-1.8	-1.5	-2.0
Medication: Atenolol	1.6	2.0	2.8	-1.2	-1.4	-1.7
Prospective memory result	1.6	2.0	3.2	-1.8	-0.8	-1.4
Pulse wave reflection index	1.5	1.8	2.8	1.7	1.4	0.9
Neck or shoulder pain in last month	1.5	2.1	3.8	-0.8	-1.9	-1.3
Number of live births	1.4	1.9	2.9	1.4	1.7	0.9
Pulse wave Arterial Stiffness index	1.4	1.6	2.2	1.5	1.1	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	2.2	-1.2	-1.5	-1.1
Cholesterol lowering medication	1.4	2.1	3.4	-1.3	-1.1	-1.8
Heart attack/myocardial infarction (self-reported)	1.4	1.9	3.6	1.4	-0.2	1.9
Irritable Bowel Disease (IBD)	1.3	3.2	4.0	-1.9	-1.4	-2.0
Verbal and Numeric Reasoning (VNR)	1.3	3.1	5.7	1.4	1.3	2.4
Ulcerative Colitis	1.3	1.9	2.4	-1.5	-1.0	-1.6
Medication for hormone replacement therapy	1.3	1.4	2.4	-1.2	0.7	-1.5
Medication: Co-codamol	1.3	1.5	2.6	1.4	0.4	1.6
Current tobacco smoking	1.3	2.1	2.4	1.3	1.5	1.5
Hearing difficulty/problems with background noise	1.3	2.1	2.8	-1.5	-1.2	-1.7
Hair/balding pattern: Pattern 2	1.3	1.6	2.7	-1.6	-0.7	-1.3
Financial difficulties in last 2 years	1.3	1.8	2.3	-1.2	-1.3	-1.5
Length of working week for main job	1.3	1.4	3.4	-1.0	-1.8	0.0
Pulse wave peak to peak time	1.3	1.6	2.2	-1.5	-1.1	-1.1
Ever had bowel cancer screening	1.3	1.5	3.3	1.0	-0.1	1.8
Commuting to job workplace: Cycle	1.3	1.5	2.1	1.5	1.1	1.1
Lung FVC	1.2	6.4	12.1	2.1	3.5	1.7
Father’s age at death	1.2	1.6	1.7	-1.3	-1.3	-1.2
Leg fat percentage (right)	1.2	4.2	6.5	2.5	1.7	1.8
Mouth/teeth dental problems: Loose teeth	1.2	1.5	1.8	-1.3	-1.0	-1.3
Reaction Time	1.1	2.0	2.2	-1.4	-1.4	-1.5
Diabetes (father)	1.1	1.4	1.6	1.3	1.0	1.2
High blood pressure (mother)	1.1	1.5	2.7	-1.3	0.4	-1.6
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.1	-0.9	-1.2	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.9	-0.5	-1.7	-1.0
Mean time to correctly identify matches	1.1	2.1	2.6	-1.4	-1.6	-1.4
Asthma (self-reported)	1.1	2.2	2.9	-1.7	-1.0	-1.7
Smoking status: Current	1.1	1.7	2.0	1.3	1.3	1.4
Illnesses of father: High blood pressure	1.1	1.3	3.2	-0.2	1.8	-0.9
Ever had prostate specific antigen (PSA) test	1.1	1.2	3.1	0.8	0.3	1.8
Breast Cancer	1.0	2.4	3.9	1.1	-1.4	2.0
LDL Cholesterol	1.0	1.5	2.3	1.5	1.0	1.1
Severe depression (siblings)	1.0	1.2	1.7	-1.2	-0.5	-1.3
Heart attack	1.0	1.3	2.6	1.1	-0.3	1.6
Hair/balding pattern: Pattern 3	1.0	1.4	2.0	-1.4	-1.4	-0.6
Asthma	1.0	1.9	2.5	-1.6	-0.9	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.4	-0.9	-0.9	-1.2
Qualifications: nursing, teaching	1.0	1.6	2.3	-1.5	-0.9	-1.2
Illnesses of father: None of the above (group 1)	1.0	1.2	1.8	1.3	0.4	1.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	1.6	-1.2	-0.6	-1.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.3	-0.8	-1.1	-1.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.1	-0.5	-1.4	-0.9
Chronic bronchitis/emphysema (father)	0.9	1.0	2.9	-0.3	0.3	-1.7
Pain all over the body in last month	0.9	1.0	1.3	-0.9	-0.9	-1.1
Medication: Simvastatin	0.9	1.3	1.8	-1.2	-1.3	-0.8
Birth weight of first child	0.9	1.6	4.5	0.1	2.1	-0.5
Gout (self-reported)	0.9	1.2	2.1	-0.9	-1.4	-0.8
Wheeze or whistling in the chest in last year	0.9	1.5	2.2	-1.2	-1.0	-1.5
Medication: Allopurinol	0.9	1.1	2.0	-0.8	-1.4	-0.9
Chest pain or discomfort	0.9	1.3	2.4	1.6	0.3	1.2
Medication: Bendroflumethiazide	0.9	1.4	2.0	-1.2	-0.8	-1.4
Medication: Lisinopril	0.9	1.2	2.3	0.9	1.5	0.7
Leg fat percentage (left)	0.9	3.4	4.9	2.2	1.5	1.8
Ovarian Cancer	0.8	1.0	2.2	-1.0	-1.5	0.0
Lung FEV1/FVC ratio	0.8	4.2	4.6	2.1	2.0	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.6	-0.7	-1.0	-1.2
Relative age voice broke	0.8	1.1	2.1	-0.5	-1.4	-1.0
Number of incorrect matches in round	0.8	1.3	1.8	-1.4	-0.7	-1.2
Pulse rate	0.8	1.4	2.8	0.9	1.7	0.6
Medication: Cholesterol lowering	0.8	1.2	2.5	1.0	0.3	1.6
Suffer from ‘nerves’	0.8	1.2	2.5	-0.9	-0.6	-1.6
Smoking status: Previous	0.8	1.2	1.9	-1.0	-1.4	-0.9
Commuting to job workplace: Walk	0.8	0.9	1.1	1.1	0.9	0.9
Average weekly champagne plus white wine intake	0.8	1.1	1.7	-1.2	-0.2	-1.3
Age started oral contraceptive pill	0.8	1.0	1.3	1.0	0.8	1.1
Ever depressed for a whole week	0.8	1.0	1.3	1.1	0.7	1.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.2	-0.9	-1.0	-1.1
Medication: Ramipril	0.7	0.9	1.3	0.9	-0.9	1.1
Noisy workplace	0.7	0.8	1.3	1.2	0.5	1.0
Angina (self-reported)	0.7	0.9	1.8	0.8	-0.3	1.3
Overall health rating	0.7	1.6	1.8	-1.2	-1.3	-1.3
High cholesterol (Self-reported)	0.7	1.2	1.5	-1.0	-1.1	-1.2
Schizophrenia (2018)	0.6	1.3	1.7	-1.1	-1.0	-1.3
Crohns Disease (2017)	0.6	1.3	1.6	-1.1	-1.0	-1.3
Major Depression (MDD)	0.6	0.7	1.6	-0.8	-1.3	-0.0
Forced vital capacity (FVC)	0.6	2.3	4.8	1.2	2.2	0.8
Fluid intelligence score	0.6	1.3	3.0	0.6	0.8	1.7
Falls in the last year	0.6	0.9	1.3	1.1	-0.2	1.1
Happiness	0.6	0.8	1.4	-0.8	-1.2	-0.4
Illnesses of mother	0.6	0.8	1.4	0.6	1.2	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.4	1.0	1.8	1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.1	0.4	1.5	0.1
Forced vital capacity (FVC), Best measure	0.6	2.1	4.3	1.0	2.1	1.0
Qualifications: College or University degree	0.6	2.0	2.6	-1.3	-1.6	-1.3
Medication for pain relief, constipation, heartburn	0.6	0.9	2.8	0.1	1.7	0.3
Medication: Omeprazole	0.6	0.7	1.2	-1.1	-0.0	-1.0
Mineral and other dietary supplements	0.6	0.8	1.2	0.9	1.1	0.8
Miserableness	0.6	1.0	1.8	1.0	0.3	1.3
Diastolic blood pressure, automated reading	0.6	1.9	2.4	0.9	1.6	1.6
Neuroticism (2016)	0.5	0.7	1.3	0.6	-1.1	0.6
Respiratory disease	0.5	1.1	1.4	-1.2	-1.0	-0.9
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.1	1.0	0.9	0.9
Angina	0.5	0.6	1.1	0.6	-0.7	1.0
Pack years adult smoking proportion	0.5	0.8	1.5	0.8	1.2	0.6
Impedance of leg (right)	0.5	2.5	3.5	1.7	1.1	1.9
Average weekly fortified wine intake	0.5	0.6	1.4	-0.5	-1.2	-0.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	0.3	1.3	0.2
Time employed in main current job	0.5	0.6	1.5	-0.4	-1.2	-0.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.7	1.1	1.9	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.8	-0.3	-1.4	-0.7
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.0	0.8	1.4	0.2
Medication: Ibuprofen	0.5	0.6	0.9	1.0	-0.6	0.7
Leg fat mass (right)	0.5	1.9	3.3	1.8	0.9	1.2
Pulse rate, automated reading	0.5	1.6	3.0	1.2	1.7	0.7
Alcohol intake frequency.	0.5	1.1	1.9	-0.5	-1.1	-1.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	1.1	0.1	0.8
Mother’s age at death	0.5	0.7	1.3	-0.8	-1.1	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	-0.9	0.0	-1.0
Pack years of smoking	0.5	0.7	1.7	0.6	1.3	0.4
Leg fat mass (left)	0.5	1.9	3.1	1.8	0.9	1.3
Bipolar Disorder or Schizophrenia	0.4	0.9	1.5	-0.5	-1.2	-1.1
Trunk fat percentage	0.4	1.5	2.7	1.6	0.6	1.2
Impedance of leg (left)	0.4	2.0	3.6	1.3	0.8	1.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.8	0.9	0.0	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	0.9	-0.8	0.3
Blood clot in the leg (DVT)	0.4	0.6	0.7	-0.6	-0.8	-0.8
Body fat percentage	0.4	1.6	3.0	1.7	0.8	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.7	-0.5	-0.8	-0.8
Heart disease (mother)	0.4	0.5	0.8	0.6	-0.4	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.8	0.6	0.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.3	1.0	0.1	1.1
Osteoarthritis (self-reported)	0.4	0.5	0.9	-0.9	-0.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.7	0.4	1.3	0.7
Medication: Atorvastatin	0.4	0.5	0.8	0.9	0.3	0.8
Alcohol drinker status: Previous	0.4	0.5	0.7	0.8	0.4	0.8
Depressed Affect (Nagel 2018)	0.3	0.6	0.9	0.9	-0.1	0.9
Depression (Nagel 2018)	0.3	0.5	0.8	-0.1	-0.9	-0.9
Alzheimer’s Disease (in father)	0.3	0.3	0.5	-0.7	-0.7	-0.2
Bipolar Disorder (2011)	0.3	0.3	0.8	0.9	0.0	0.0
Coronary Artery Disease (CAD)	0.3	0.3	0.7	-0.8	0.0	-0.5
Crohns Disease (2012)	0.3	0.4	0.7	0.7	-0.2	0.8
Blood White Count	0.3	2.6	3.3	1.7	1.8	1.1
Systolic Blood Pressure	0.3	1.4	2.3	0.9	1.1	1.5
Cardiovascular Disease	0.3	1.1	1.3	-1.1	-1.2	-0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.5	0.5	-0.8
Townsend deprivation index at recruitment	0.3	0.4	1.0	0.4	1.0	0.2
Maternal smoking around birth	0.3	0.5	0.9	-0.3	-0.7	-1.0
Trunk fat mass	0.3	1.1	2.2	1.5	0.5	1.0
Waist circumference	0.3	1.2	2.1	1.5	0.6	1.1
Mouth/teeth dental problems	0.3	0.4	0.4	-0.6	-0.7	-0.6
Impedance of arm (right)	0.3	1.5	3.5	-0.8	-1.9	-0.5
Alcohol intake versus 10 years previously	0.3	0.5	1.4	-0.1	-1.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.6	-0.6	-0.6	-0.8
Whole body fat mass	0.3	1.2	2.4	1.5	0.6	1.0
Comparative height size at age 10	0.3	1.6	3.1	1.2	0.5	1.8
Knee pain experienced in last month	0.3	0.5	0.7	-0.5	-0.7	-0.8
Loneliness, isolation	0.3	0.4	0.9	1.0	0.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.4	0.7	0.5	0.5
Breast cancer (self-reported)	0.3	0.4	0.6	0.8	-0.2	0.8
Osteoporosis (self-reported)	0.3	0.3	0.5	0.4	0.7	0.5
Medication: Paracetamol	0.3	0.5	0.7	-0.4	-0.8	-0.8
Myopia	0.3	0.5	1.2	-0.4	-1.1	0.1
Heart disease (siblings)	0.3	0.4	0.6	0.4	-0.7	0.7
Bipolar Disorder (2018)	0.2	0.3	0.6	0.6	-0.7	-0.1
Mean Putamen Volume	0.2	0.2	0.5	0.4	0.0	0.7
Fasting Glucose	0.2	0.3	0.7	0.2	0.9	0.0
Primary Biliary Cirrhosis	0.2	0.3	0.7	-0.3	-0.8	-0.5
Schizophrenia (2014)	0.2	0.5	0.7	-0.6	-0.8	-0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.6	-0.0	0.6
Blood Red Count	0.2	1.5	3.6	0.9	1.9	0.2
Waist Hip Ratio (WHR)	0.2	0.7	1.7	0.6	0.4	1.3
Smoking Status	0.2	0.5	0.8	0.8	0.1	0.9
Average weekly spirits intake	0.2	0.2	0.4	-0.4	-0.3	-0.6
Sensitivity / hurt feelings	0.2	0.3	0.6	0.3	0.8	-0.5
Relative age of first facial hair	0.2	0.4	0.9	0.3	-0.9	0.4
Medication: Metformin	0.2	0.2	0.7	-0.1	-0.8	0.2
Diabetes (mother)	0.2	0.3	0.6	0.6	0.8	-0.1
Hand grip strength (right)	0.2	0.5	1.4	0.1	1.2	-0.2
Age when periods started (menarche)	0.2	0.4	0.7	0.6	0.1	0.8
Stomach or abdominal pain in last month	0.2	0.3	0.8	-0.2	0.1	-0.9
Body mass index (BMI)	0.2	0.9	1.7	1.3	0.8	0.5
Past tobacco smoking	0.2	0.5	0.8	0.6	0.9	0.4
Had other major operations	0.2	0.2	0.4	0.6	-0.1	0.5
Diabetes (self-reported)	0.2	0.3	0.6	0.6	0.1	0.8
Weight	0.2	0.9	1.7	1.3	0.7	0.7
Depression (self-reported)	0.2	0.3	0.8	0.9	-0.1	0.1
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.4	-0.6	0.1
Peak expiratory flow (PEF)	0.2	0.5	0.8	-0.6	-0.5	-0.9
Loud music exposure frequency	0.2	0.2	0.3	-0.2	-0.4	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	0.6	0.5	-0.2
Medication: Paracetamol	0.2	0.4	0.6	-0.2	-0.8	-0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.4	-0.2	-0.8
Medication: Amlodipine	0.2	0.2	0.6	0.3	-0.8	-0.0
Comparative body size at age 10	0.2	0.5	0.7	-0.8	-0.8	-0.3
Worry too long after embarrassment	0.2	0.3	0.7	-0.1	-0.4	-0.8
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.7	0.2	0.3
Medication: Blood pressure	0.2	0.3	0.5	0.4	-0.4	0.7
Arm predicted mass (right)	0.2	0.8	1.5	0.9	1.2	0.5
Leg pain on walking	0.2	0.2	0.3	-0.3	-0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	-0.1	0.8	-0.3
Supplements: Vitamin C	0.2	0.3	0.5	-0.7	0.4	-0.5
Average weekly red wine intake	0.2	0.2	0.4	-0.5	-0.6	-0.2
Diabetes diagnosed by doctor	0.2	0.3	0.5	0.6	0.3	0.7
Eye problems/disorders: Cataract	0.2	0.3	0.6	-0.2	-0.8	-0.4
Arm fat mass (left)	0.2	0.7	1.5	1.2	0.6	0.5
Commuting to job workplace: Public transport	0.2	0.3	0.6	0.8	0.1	0.5
Medication: Blood pressure	0.2	0.4	0.7	-0.7	-0.2	-0.9
Number of operations (self-reported)	0.2	0.3	0.5	0.7	0.3	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.6	0.2	0.1	0.8
Blood Eosinophil Count	0.1	0.6	1.2	-0.8	-0.1	-1.1
Heel T-Score	0.1	0.5	0.8	0.2	0.8	0.9
BMI	0.1	0.5	1.1	1.1	0.4	0.3
Neuroticism	0.1	0.1	0.3	0.5	-0.2	0.3
Tanning	0.1	1.4	1.6	-1.3	-1.0	-1.3
Vitamin and mineral supplements	0.1	0.2	0.3	0.6	0.3	0.4
Fed-up feelings	0.1	0.1	0.2	0.4	0.1	0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	-0.2	-0.1	-0.6
Multivitamins +/- minerals	0.1	0.1	0.2	0.0	0.1	-0.4
Nervous feelings	0.1	0.3	0.7	0.8	0.1	0.3
Had menopause	0.1	0.1	0.2	0.5	-0.0	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	0.4	0.3	0.7
Hip circumference	0.1	0.5	1.0	1.0	0.6	0.5
Impedance of arm (left)	0.1	0.7	1.6	-0.6	-1.3	-0.3
Arm fat mass (right)	0.1	0.4	1.1	1.0	0.4	0.2
Tense / ‘highly strung’	0.1	0.1	0.2	0.0	-0.4	-0.4
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	0.1	0.1	-1.0
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.0	0.4	0.0
Birth weight	0.1	0.2	0.4	-0.6	0.3	-0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.4	0.3	-0.3
Arm fat-free mass (right)	0.1	0.7	1.1	0.8	1.1	0.5
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.3	0.3	-0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	0.3	0.1
Number of full sisters	0.1	0.1	0.4	0.6	0.1	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.0	0.5	-0.0
Illnesses of siblings: Diabetes	0.1	0.1	0.3	0.1	0.3	-0.5
Arm fat percentage (left)	0.1	0.3	0.9	0.9	0.1	0.2
Mood swings	0.1	0.2	0.4	0.5	-0.4	0.6
Friendships satisfaction	0.1	0.1	0.3	-0.3	-0.5	-0.1
Medication: Aspirin	0.1	0.2	0.4	0.2	-0.2	0.6
Wears glasses or contact lenses	0.1	0.1	0.1	-0.3	-0.3	0.0
Financial situation satisfaction	0.1	0.2	0.4	-0.1	-0.6	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.0	-0.5	0.5
Alcohol drinker status: Never	0.1	0.1	0.2	0.4	0.3	-0.2
Ever smoked	0.1	0.1	0.4	-0.2	-0.6	-0.0
Arm fat-free mass (left)	0.1	0.7	1.0	0.8	1.0	0.5
Irritability	0.1	0.2	0.5	-0.1	-0.7	-0.2
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.2	0.5	-0.3
Arm predicted mass (left)	0.1	0.6	1.2	0.8	1.1	0.3
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.5	-0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	-0.2	0.1	0.1
Worry (Nagel 2018)	0.0	0.0	0.1	0.2	0.2	-0.2
Body Mass Index (BMI) (2010)	0.0	0.1	0.2	0.4	0.2	0.1
HbA1C	0.0	0.1	0.1	0.2	-0.4	0.1
Height	0.0	0.7	1.6	0.6	0.1	1.3
Hair Pigment	0.0	0.2	0.4	0.7	-0.4	-0.3
Hand grip strength (left)	0.0	0.0	0.1	-0.2	0.2	-0.2
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	0.1	-0.3	-0.2
Leg fat-free mass (left)	0.0	0.1	0.1	0.1	0.2	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.1	0.0	0.1	0.3
High blood pressure	0.0	0.1	0.1	-0.0	0.4	0.3
Sitting height	0.0	0.1	0.2	0.3	0.4	0.1
Leg predicted mass (left)	0.0	0.1	0.2	-0.0	0.2	-0.5
Neuroticism score	0.0	0.1	0.1	0.2	-0.2	-0.4
Arm fat percentage (right)	0.0	0.2	0.5	0.7	-0.2	-0.0
Trunk fat-free mass	0.0	0.1	0.2	0.3	0.5	-0.0
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	-0.0	-0.4	-0.1
Trunk predicted mass	0.0	0.2	0.4	0.4	0.6	0.1
Standing height	0.0	0.1	0.4	0.1	-0.1	0.6
Number of full brothers	0.0	0.1	0.1	0.1	0.2	-0.4
Number of children fathered	0.0	0.1	0.1	-0.4	-0.2	0.0
Age at last live birth	0.0	0.0	0.0	-0.2	-0.2	-0.2
Family relationship satisfaction	0.0	0.0	0.1	0.3	-0.1	0.0
Medication: Aspirin	0.0	0.0	0.1	-0.1	-0.2	0.3
Hypertension (Self-reported)	0.0	0.1	0.3	-0.6	0.1	-0.2
Whole body fat-free mass	0.0	0.1	0.2	0.3	0.4	-0.1
Leg fat-free mass (right)	0.0	0.1	0.2	-0.2	-0.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.2	0.1	-0.0	-0.4
Whole body water mass	0.0	0.1	0.2	0.3	0.5	-0.1
Leg predicted mass (right)	0.0	0.1	0.3	-0.3	-0.1	-0.5
Guilty feelings	0.0	0.0	0.0	0.0	-0.0	-0.1
Basal metabolic rate	0.0	0.2	0.3	0.5	0.5	0.0
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	0.1	-0.0	-0.4
Impedance of whole body	0.0	0.2	0.4	0.1	-0.5	0.6

Hub : Genes

SH2D2A

Models

Trait associations