Hub : Genes

SLC1A2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0398	0.0166	4.8e-03	0.013	0.021	0.017	0.021	0.020	4.3e-03	3.5e-04	9.8e-04	3e-04	5.0e-04
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0334	0.0179	7.5e-03	0.005	0.007	0.002	NA	-0.002	9.0e-02	5.3e-02	2.0e-01	NA	6.3e-01
3	TCGA	Prostate Adenocarcinoma	0.1490	0.0466	1.8e-05	0.090	0.060	0.077	NA	0.077	1.2e-09	7.0e-07	2.0e-08	NA	1.9e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.9	2.2	0.6	-0.3	-1.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	0.2	-0.8	-0.2
Depressed Affect (Nagel 2018)	0.1	0.3	0.6	-0.8	-0.2	-0.4
Depression (Nagel 2018)	0.3	0.4	0.6	-0.8	0.4	-0.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.4	-0.8	1.6	-0.7
Neuroticism (Nagel 2018)	0.2	0.5	0.8	-0.9	-0.9	-0.0
Schizophrenia (2018)	0.2	0.5	0.8	-0.2	-0.8	0.9
Schizophrenia vs Biploar Disorder	0.8	1.1	2.0	1.4	0.9	0.7
Worry (Nagel 2018)	0.2	0.5	0.9	0.1	-0.7	-1.0
Alzheimer’s Disease (in mother)	0.7	0.8	1.2	-0.7	-1.1	0.8
Alzheimer’s Disease (in father)	0.4	0.4	0.7	0.8	-0.5	-0.6
Alzheimer’s Disease (including proxy)	0.4	0.5	1.5	0.3	-1.2	0.0
Crohns Disease (2017)	1.7	3.6	9.7	0.6	3.1	-1.0
Irritable Bowel Disease (IBD)	0.5	1.2	2.9	1.7	0.6	-0.5
Ulcerative Colitis (UC)	1.1	2.0	3.1	1.7	-1.8	0.1
Major Depression (MDD)	2.2	2.7	4.0	2.0	-1.0	1.7
Reaction Time	0.4	0.8	1.6	0.9	-1.3	-0.3
Verbal and Numeric Reasoning (VNR)	0.8	2.0	3.6	-1.4	1.9	-0.7
Breast Cancer	0.4	0.9	1.9	0.9	-0.3	1.4
Ovarian Cancer	0.4	0.5	1.0	1.0	-0.3	-0.7
Prostate Cancer	0.0	0.0	0.1	0.0	-0.2	0.0
Age at First Birth	0.2	0.3	0.8	-0.2	0.4	-0.9
Bipolar Disorder (2011)	1.5	1.5	3.7	-0.7	-0.4	-1.9
Body Mass Index (BMI) (2010)	0.7	0.9	1.6	1.0	-1.3	0.3
Coronary Artery Disease (CAD)	1.4	1.6	3.4	0.7	-1.8	1.0
Crohns Disease (2012)	0.4	0.7	2.0	-0.1	1.4	-0.1
Mean Putamen Volume	0.9	1.0	2.4	1.6	0.4	0.6
Fasting Glucose	0.6	0.7	0.8	0.7	-0.9	-0.9
HbA1C	0.7	0.8	2.3	0.4	0.1	1.5
HDL Cholesterol	1.5	2.6	5.7	2.4	-1.1	-1.0
LDL Cholesterol	1.4	2.2	5.6	-0.6	-2.4	-0.8
Lupus	0.1	0.1	0.2	0.5	0.2	-0.2
Neuroticism (2016)	0.8	1.1	1.4	0.9	1.0	-1.2
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.2	-0.1	0.0
Rheumatoid Arthritis	1.3	1.7	3.5	1.3	-1.9	-0.4
Schizophrenia (2014)	0.1	0.2	0.4	0.6	-0.5	-0.1
Triglycerides	2.9	4.7	7.4	-2.7	-1.1	2.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.6	-0.8	-0.7	0.6
Ulcerative Colitis	1.6	2.4	4.9	1.0	-2.2	1.1
Blood Eosinophil Count	0.7	5.4	15.8	0.0	-4.0	0.6
Blood Platelet Count	0.3	3.9	11.4	-0.2	-3.4	0.3
Blood Red Count	0.2	1.8	1.9	1.4	-1.3	-1.4
Blood White Count	0.2	1.8	3.5	1.9	-0.5	-1.2
Heel T-Score	0.2	1.2	3.1	-0.7	1.8	-0.1
BMI	0.4	2.2	3.9	-1.2	-1.1	2.0
Height	0.4	7.2	15.5	1.0	3.9	-2.2
Waist Hip Ratio (WHR)	1.4	6.5	14.0	3.7	-2.3	-0.5
Systolic Blood Pressure	0.2	1.2	2.6	-0.9	0.1	1.6
Smoking Status	0.4	0.9	1.9	1.4	0.5	0.8
Allergy or Eczema	0.5	1.3	3.3	-0.7	-1.8	0.5
Cardiovascular Disease	0.1	0.3	0.9	0.3	-0.9	0.2
Hypothyroidism (self reported)	10.8	24.8	66.8	2.7	-8.2	-0.4
Respiratory disease	1.3	2.9	7.8	0.8	-0.6	2.8
Type 2 Diabetes (T2D) (2018)	1.1	2.1	6.1	-0.2	-2.5	-0.0
Lung FEV1/FVC ratio	2.1	10.9	22.6	-1.7	-4.7	-2.7
Lung FVC	0.2	1.1	1.3	-1.0	1.1	-1.0
Neuroticism	0.2	0.6	1.8	0.0	-0.1	-1.3
Chronotype (morning person)	0.2	0.6	1.3	-0.0	0.6	-1.2
Hair Pigment	0.1	3.7	9.3	-0.5	-3.0	1.2
Tanning	0.1	1.5	3.4	-0.8	-0.7	1.8
Hand grip strength (left)	1.4	3.8	11.1	-0.4	3.3	-0.4
Number of treatments/medications taken	0.8	1.4	3.2	1.8	-1.0	-0.0
Average weekly spirits intake	1.3	1.6	3.5	1.9	-0.6	0.9
Sensitivity / hurt feelings	0.5	0.8	1.6	-0.9	1.3	-0.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.7	0.0	0.9	-1.9
Hearing difficulty/problems: Yes	0.4	0.6	1.5	0.5	-1.2	-0.2
Relative age of first facial hair	0.6	1.2	1.8	1.3	-0.6	1.2
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.0	-0.6	-1.7	-1.6
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.5	1.6	0.9	0.7
Ever had hysterectomy (womb removed)	1.4	1.6	3.1	1.1	0.7	1.8
Systolic blood pressure, automated reading	0.6	1.8	3.3	-0.1	-1.5	1.8
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	4.7	-2.2	-0.4	0.8
Angina	1.8	2.4	4.3	1.2	-2.1	-1.2
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.0	-0.0	-0.6
Vitamin and mineral supplements	1.8	2.5	6.6	0.0	-2.6	1.0
Supplements: Zinc	0.0	0.0	0.1	0.2	-0.3	-0.2
Medication: Co-codamol	2.2	2.6	5.6	1.4	-0.2	-2.4
Medication: Metformin	0.2	0.3	1.0	-1.0	-0.1	-0.0
Diabetes (father)	0.9	1.2	2.2	-1.0	-0.4	1.5
Diabetes (mother)	3.0	3.8	11.3	0.2	-3.4	0.2
Severe depression (siblings)	2.8	3.1	6.9	0.2	-1.6	-2.6
Pack years adult smoking proportion	1.1	1.7	3.6	1.9	1.2	0.0
Impedance of leg (right)	0.7	3.4	5.3	2.3	-2.2	-0.0
Leg fat-free mass (left)	0.3	1.8	3.2	-1.0	1.8	-1.1
Trunk fat percentage	0.9	3.7	9.2	1.4	-3.0	-0.0
Hand grip strength (right)	1.2	3.2	8.5	-0.9	2.9	-0.5
Townsend deprivation index at recruitment	0.4	0.6	1.0	0.6	0.7	1.0
Current tobacco smoking	0.1	0.1	0.3	0.5	-0.1	0.1
Average weekly fortified wine intake	0.2	0.3	0.6	0.5	-0.8	-0.1
Maternal smoking around birth	1.5	2.2	3.8	0.7	-1.9	1.5
Fed-up feelings	0.3	0.5	1.1	-1.0	0.4	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.3	0.8	-0.4
Relative age voice broke	0.8	1.3	2.6	-1.6	0.0	1.1
Taking other prescription medications	2.1	3.2	9.3	0.6	-3.0	-0.2
Age when periods started (menarche)	0.1	0.2	0.2	0.4	-0.5	0.3
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	4.1	0.0	-0.3	2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.8	-0.1	0.7	-1.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.4	0.8	1.2	0.7
Qualifications: CSEs or equivalent	0.2	0.3	0.8	0.3	-0.9	0.2
Serious illness, injury or assault to yourself	0.3	0.3	0.9	0.1	0.4	-0.9
High blood pressure	0.3	0.9	1.3	0.8	-1.1	0.9
Hayfever, allergic rhinitis or eczema	1.1	2.4	6.7	-0.7	-2.6	-0.0
Multivitamins +/- minerals	1.4	1.7	3.1	-0.6	1.8	-1.4
Stomach or abdominal pain in last month	0.2	0.3	0.9	-0.0	-0.0	-0.9
Supplements: Glucosamine	1.0	1.3	2.0	1.4	-0.3	-1.4
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	4.5	-1.8	-2.1	0.6
Medication: Atenolol	0.0	0.0	0.0	-0.2	-0.1	-0.1
Medication: Levothyroxine sodium	12.1	20.5	55.3	2.5	-7.4	-0.1
Sitting height	0.6	4.1	9.7	-1.4	3.1	-0.9
Chronic bronchitis/emphysema (father)	1.6	1.9	5.1	0.5	-0.5	-2.2
High blood pressure (mother)	2.9	4.1	10.5	3.2	-1.3	-0.4
Body mass index (BMI)	0.2	1.0	2.6	-0.4	-1.6	0.4
Impedance of leg (left)	0.5	2.2	3.5	1.7	-1.9	0.5
Leg predicted mass (left)	0.3	1.7	3.1	-0.9	1.8	-1.2
Trunk fat mass	0.3	1.5	3.5	1.0	-1.9	-0.1
Waist circumference	0.3	1.0	2.5	0.6	-1.6	0.1
Number of incorrect matches in round	0.4	0.7	1.1	1.1	-0.2	1.0
Past tobacco smoking	0.5	1.0	2.0	0.7	-0.7	-1.4
Alcohol usually taken with meals	1.6	2.5	3.5	-1.9	1.8	-0.9
Nervous feelings	0.6	1.1	2.6	0.6	0.5	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	5.2	-0.6	2.3	-1.6
Hearing difficulty/problems with background noise	0.3	0.5	1.0	1.0	-0.2	0.7
Hair/balding pattern: Pattern 2	0.4	0.5	0.7	0.7	-0.8	0.4
Had menopause	1.1	1.4	2.2	0.1	1.5	-1.4
Had other major operations	0.7	0.9	1.7	-1.3	0.9	-0.2
Forced vital capacity (FVC)	0.6	2.5	5.8	-1.0	2.4	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.3	-1.1	0.2	-0.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.2	1.0	-0.9	1.1
Qualifications: None of the above	0.7	1.5	2.1	1.5	-1.1	1.0
Financial difficulties in last 2 years	0.2	0.2	0.4	0.3	-0.7	-0.4
Mouth/teeth dental problems	0.8	1.2	2.9	-0.4	0.6	-1.7
Heart attack	0.2	0.3	0.6	0.2	-0.5	0.8
Allergy	0.9	2.2	5.0	0.6	2.2	-1.1
Pain all over the body in last month	0.8	0.8	2.0	-0.2	-1.4	0.7
Diabetes (self-reported)	0.9	1.3	2.8	-0.9	-1.7	0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.2	-0.5	-0.6
Medication: Ramipril	0.7	1.0	2.2	0.6	0.5	1.5
Medication: Simvastatin	0.5	0.8	2.2	0.2	-1.5	-0.3
Fluid intelligence score	0.3	0.6	1.4	-0.6	1.2	-0.1
Illnesses of siblings	0.7	1.0	2.1	-0.1	1.4	-1.0
Neuroticism score	0.3	0.6	1.7	-0.2	-0.1	-1.3
Weight	0.0	0.1	0.2	-0.2	0.2	-0.5
Impedance of arm (right)	1.5	6.9	10.0	3.1	-3.2	-1.2
Arm fat percentage (right)	1.3	5.2	14.3	1.1	-3.8	0.3
Trunk fat-free mass	0.7	4.0	9.9	-1.2	3.1	-0.8
Hip circumference	0.1	0.3	0.4	-0.6	-0.7	-0.1
Time employed in main current job	1.7	1.9	4.8	-2.2	0.8	0.5
Alcohol intake versus 10 years previously	0.3	0.5	1.2	0.4	-1.1	-0.2
Father’s age at death	0.4	0.5	0.8	0.5	0.7	-0.9
Worrier / anxious feelings	0.1	0.1	0.3	0.3	0.6	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.3	1.2	-0.9	-0.3
Falls in the last year	0.6	0.8	1.9	1.4	-0.7	0.3
Hair/balding pattern: Pattern 3	0.8	1.2	2.2	-0.3	1.5	-1.2
Number of live births	0.2	0.3	0.8	0.4	-0.1	0.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	2.9	-1.7	0.7	-1.5
Pulse rate	0.2	0.4	0.7	0.4	0.8	0.6
Happiness	0.0	0.1	0.2	-0.4	-0.0	-0.0
Noisy workplace	0.1	0.1	0.4	0.2	0.1	0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.1	-1.1	0.3	-0.9
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.0	-0.7	1.1	-1.4
Mouth/teeth dental problems: Dentures	0.4	0.6	1.3	0.6	1.1	0.4
Asthma	1.0	1.9	4.8	-0.1	-1.0	2.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	-1.0	-0.4	0.3
Medication: Cholesterol lowering	0.4	0.6	1.5	-0.6	-1.2	0.2
Depression (self-reported)	1.5	1.8	4.8	0.5	0.6	-2.2
Medication: Lansoprazole	1.0	1.2	3.4	-0.1	-1.9	-0.2
Prospective memory result	0.9	1.1	2.7	1.7	0.1	-0.8
Lung cancer (father)	0.2	0.3	0.4	-0.6	-0.1	0.6
Illnesses of mother	2.3	2.9	7.0	-2.6	1.3	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.3	-1.0	0.1	-1.5
Pulse wave Arterial Stiffness index	1.0	1.1	1.5	1.0	-1.0	-1.2
Impedance of arm (left)	0.9	4.1	6.7	2.2	-2.6	-0.8
Arm fat mass (right)	0.4	1.5	4.1	0.6	-2.0	0.1
Trunk predicted mass	0.7	3.9	9.8	-1.1	3.1	-0.8
Standing height	0.7	6.5	14.4	0.3	3.8	-2.2
Length of working week for main job	1.1	1.2	1.7	0.7	-1.3	-1.2
Exposure to tobacco smoke at home	0.4	0.5	0.9	0.5	-1.0	0.5
Breastfed as a baby	0.3	0.4	0.9	0.5	0.9	-0.4
Tense / ‘highly strung’	2.4	4.0	9.5	-0.5	1.5	-3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	3.9	1.5	-0.0	-2.0
Hair/balding pattern: Pattern 4	0.4	0.9	2.7	-1.6	0.1	-0.1
Birth weight of first child	0.1	0.2	0.4	-0.7	0.2	-0.4
Peak expiratory flow (PEF)	0.3	0.6	1.1	-1.1	-0.1	-0.9
Pulse wave reflection index	0.1	0.1	0.3	-0.5	-0.2	-0.0
Ever highly irritable/argumentative for 2 days	0.6	0.8	2.1	1.4	-0.0	0.5
Loud music exposure frequency	1.3	1.4	2.7	0.8	-1.6	1.0
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.5	-2.1	0.4	0.7
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.5	-0.4	-1.2	1.1
Blood clot in the leg (DVT)	0.5	0.6	1.1	-0.8	0.3	1.1
Medication: Paracetamol	0.6	1.1	2.8	1.7	-0.1	0.6
Headache pain in last month	0.8	1.4	2.7	0.4	1.1	1.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	0.3	0.7	0.1
Glaucoma (self-reported)	1.8	2.2	6.0	-0.3	2.5	-0.6
Gout (self-reported)	0.3	0.4	1.2	-1.1	-0.0	-0.1
Hypothyroidism/myxoedema (self-reported)	11.4	22.2	62.1	2.2	-7.9	0.1
Medication: Amlodipine	1.8	2.5	3.0	-1.4	1.6	1.7
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.6	-1.3	-0.3	-0.6
Birth weight	1.0	2.1	5.6	0.8	2.4	-0.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.1	-0.6	1.1	0.2
High blood pressure (siblings)	1.5	2.1	4.5	-0.1	-2.1	1.3
Forced vital capacity (FVC), Best measure	0.3	1.1	1.8	-0.4	1.3	-1.1
Body fat percentage	1.2	4.7	12.2	1.3	-3.5	0.5
Leg fat percentage (right)	1.6	5.9	14.0	1.5	-3.7	1.2
Arm fat-free mass (right)	0.8	4.1	8.3	-2.0	2.9	-0.4
Exposure to tobacco smoke outside home	2.0	2.7	7.6	2.8	-0.6	0.1
Comparative body size at age 10	0.2	0.6	1.3	-1.1	0.2	-0.6
Number of full brothers	2.1	2.6	4.0	2.0	-1.9	-0.6
Worry too long after embarrassment	0.3	0.5	0.9	-0.8	1.0	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.4	0.4	0.6	-1.6
Wheeze or whistling in the chest in last year	1.1	1.9	2.6	1.6	-0.8	1.6
Number of children fathered	0.8	0.9	1.7	0.8	0.6	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.2	1.1	-0.1	-0.3
Age at first live birth	0.3	0.6	1.7	-0.0	1.3	0.2
Pulse wave peak to peak time	0.8	1.0	1.4	-0.7	1.2	1.0
Health satisfaction	0.4	0.5	1.0	0.6	-1.0	-0.3
Shortness of breath walking on level ground	1.2	1.4	3.8	-2.0	0.6	0.0
Qualifications: College or University degree	0.4	1.2	2.7	0.2	0.9	-1.6
Eye problems/disorders: None of the above	0.4	0.4	1.1	0.1	0.3	-1.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	-0.0	-0.0	0.8
Emphysema/chronic bronchitis	0.9	1.1	3.0	1.7	-0.4	-0.1
Medication for pain relief, constipation, heartburn	0.5	0.8	0.9	-1.0	0.8	-0.9
Neck or shoulder pain in last month	0.7	1.1	2.7	1.6	-0.7	0.1
Medication: Blood pressure	0.3	0.5	1.6	0.2	-1.2	-0.1
Angina (self-reported)	2.1	2.7	4.8	1.4	-2.2	-1.1
Migraine (self-reported)	1.0	1.3	2.1	1.4	0.4	-1.2
Medication: Ibuprofen	0.2	0.2	0.3	-0.5	-0.2	-0.6
Medication: Allopurinol	0.1	0.1	0.2	-0.5	-0.3	-0.1
Medication: Omeprazole	0.6	0.8	2.3	0.0	0.0	1.5
Medication: Seretide 50 evohaler	1.3	1.5	2.8	-0.9	-1.7	0.9
Mean time to correctly identify matches	1.2	2.2	3.1	1.8	-1.5	-1.1
Heart disease (mother)	0.7	0.8	2.4	1.6	0.0	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	0.0	0.7	-1.0
Whole body fat mass	0.4	1.7	4.1	0.9	-2.0	0.1
Leg fat mass (right)	0.5	2.0	4.9	0.7	-2.2	0.7
Arm predicted mass (right)	0.6	2.9	6.4	-1.5	2.5	-0.3
Pulse rate, automated reading	0.3	1.1	1.7	-1.0	1.3	0.7
Alcohol intake frequency.	0.4	0.9	1.7	0.9	-0.1	-1.3
Comparative height size at age 10	0.7	3.8	9.2	-0.6	3.0	-1.3
Number of full sisters	1.1	1.3	3.6	0.2	-1.9	-0.5
Suffer from ‘nerves’	0.6	0.9	2.6	0.3	-1.6	-0.1
Overall health rating	0.6	1.4	2.4	1.2	-1.6	-0.3
Chest pain or discomfort	0.5	0.7	1.3	1.2	-0.7	0.3
Had major operations	0.1	0.1	0.2	0.4	0.3	0.4
Age at last live birth	0.3	0.4	0.6	0.6	0.8	-0.6
Family relationship satisfaction	0.9	1.2	2.5	1.6	-0.8	0.6
Leg pain on walking	1.0	1.3	3.3	0.5	1.8	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.2	1.5	-1.0	0.0
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.0	0.5	-0.8	1.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	4.1	0.0	-0.0	2.0
Medication: Aspirin	1.1	1.5	2.5	1.4	-1.6	0.3
Supplements: Vitamin C	0.3	0.3	0.9	-0.1	0.9	-0.3
Knee pain experienced in last month	0.5	0.8	1.9	-1.4	0.5	-0.4
Hypertension (Self-reported)	0.3	0.8	1.7	0.3	-1.3	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.9	0.9	1.0	-0.2
Illnesses of father: Heart disease	0.1	0.1	0.2	0.1	0.4	0.0
Illnesses of siblings: Diabetes	0.6	0.7	1.0	0.8	-0.7	-1.0
Smoking status: Previous	0.4	0.5	1.2	-0.1	0.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.4	0.5	0.9	-1.2
Whole body fat-free mass	0.6	3.2	7.1	-1.3	2.7	-0.9
Leg fat-free mass (right)	0.5	2.7	4.9	-1.4	2.2	-1.1
Arm fat percentage (left)	1.1	4.5	12.8	0.6	-3.6	0.6
Average weekly red wine intake	2.0	3.0	6.2	-0.9	2.5	-1.4
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.2	0.0	0.1
Mood swings	0.1	0.3	0.4	-0.1	-0.6	-0.6
Loneliness, isolation	0.4	0.6	1.5	-0.2	0.4	-1.2
Long-standing illness, disability or infirmity	1.3	2.0	4.3	-1.2	-2.1	0.5
Ever had bowel cancer screening	1.1	1.2	2.2	1.5	0.8	0.9
Diabetes diagnosed by doctor	1.4	2.3	5.7	-0.6	-2.4	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	4.9	0.2	-2.2	0.6
Friendships satisfaction	0.7	0.9	2.4	1.6	-0.2	0.3
Qualifications: nursing, teaching	0.3	0.4	1.1	0.4	-0.2	-1.0
Commuting to job workplace: Walk	0.2	0.3	0.5	-0.4	-0.7	-0.4
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.1	0.0	0.7
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.2	0.3	-1.4	1.5
Medication for cholesterol	0.0	0.0	0.1	-0.2	0.3	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.1	0.8	-0.5	-1.0
Back pain experienced in last month	0.1	0.1	0.2	-0.0	0.4	-0.3
Mineral and other dietary supplements	0.8	1.1	2.5	0.7	-1.6	0.6
Breast cancer (self-reported)	2.0	2.4	4.8	-0.6	2.2	-1.5
Asthma (self-reported)	1.1	2.1	5.1	-0.1	-1.2	2.2
Osteoporosis (self-reported)	0.0	0.0	0.0	-0.0	0.2	0.1
Osteoarthritis (self-reported)	2.1	2.7	4.9	2.2	-1.3	-1.2
Medication: Aspirin	0.8	1.0	2.1	1.0	-1.4	0.1
Medication: Gliclazide	0.4	0.5	0.9	-0.7	0.1	-0.9
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.6	-0.4	-0.3
Smoking status: Current	0.0	0.0	0.0	0.1	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	2.9	-1.5	-0.2	-1.7
Whole body water mass	0.6	3.5	7.8	-1.4	2.8	-0.9
Leg predicted mass (right)	0.5	2.7	5.0	-1.4	2.2	-1.1
Arm fat mass (left)	0.3	1.0	3.1	0.1	-1.8	0.1
Number of self-reported non-cancer illnesses	1.6	2.8	6.9	1.2	-2.6	-0.4
Average weekly champagne plus white wine intake	0.1	0.2	0.4	0.7	0.2	0.3
Miserableness	0.2	0.4	0.8	0.9	-0.5	-0.3
Guilty feelings	0.8	1.2	3.2	0.7	-1.8	-0.3
Wears glasses or contact lenses	1.0	1.2	2.4	1.6	1.1	-0.2
Ever taken oral contraceptive pill	0.6	0.6	1.2	0.4	0.8	-1.1
Hearing aid user	1.7	2.0	4.0	-1.1	2.0	0.8
Mother’s age at death	1.2	1.5	3.1	1.0	-0.8	-1.8
Financial situation satisfaction	1.6	2.0	5.0	0.2	-0.9	2.2
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.1	-0.3	-0.8	1.8
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.6	0.3	0.3
Eye problems/disorders: Glaucoma	1.5	1.8	5.4	0.1	2.3	0.1
Medication: Blood pressure	0.5	0.9	2.0	0.8	0.4	1.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	0.6	0.9	0.3
Supplements: Fish oil (including cod liver oil)	2.0	2.6	3.9	-1.8	2.0	0.8
High cholesterol (Self-reported)	0.0	0.1	0.2	-0.1	-0.4	-0.2
Medication: Bendroflumethiazide	0.4	0.7	1.6	0.6	-0.3	1.3
Medication: Paracetamol	1.3	2.1	6.0	2.5	0.3	-0.4
Medication: Lisinopril	1.9	2.5	4.5	-1.2	-2.1	1.2
Medication: Atorvastatin	0.1	0.2	0.4	-0.1	0.2	-0.6
Illnesses of father: High blood pressure	0.7	0.8	1.2	0.8	0.9	1.1
Alcohol drinker status: Never	1.8	2.2	4.8	-0.0	-2.2	1.3
Ever smoked	0.7	1.2	3.0	-0.8	0.3	1.7
Basal metabolic rate	0.4	2.1	4.4	-1.1	2.1	-0.9
Leg fat percentage (left)	1.4	5.1	12.0	1.2	-3.5	1.4
Arm fat-free mass (left)	0.5	2.3	5.2	-1.2	2.3	-0.3
Number of operations (self-reported)	0.1	0.1	0.3	-0.6	-0.1	0.2
Average weekly beer plus cider intake	1.3	1.9	4.8	-0.4	-2.2	0.9
Irritability	0.0	0.0	0.1	0.1	-0.4	0.0
Risk taking	0.3	0.4	0.7	0.2	-0.7	-0.9
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.2	0.2	0.4
Fractured/broken bones in last 5 years	3.1	4.1	11.5	-3.4	-0.2	0.8
Age started oral contraceptive pill	0.1	0.1	0.2	-0.1	-0.4	0.1
Diastolic blood pressure, automated reading	1.0	3.0	6.7	0.1	-2.6	1.6
Ever depressed for a whole week	0.1	0.2	0.4	0.6	0.2	0.1
Unable to work because of sickness or disability	1.1	1.5	4.2	-0.3	0.5	-2.0
Commuting to job workplace: Cycle	0.5	0.6	1.1	0.7	0.4	-1.1
Myopia	0.2	0.4	0.8	-0.9	-0.4	0.3
Vascular/heart problems diagnosed by doctor	0.6	1.7	2.8	-1.2	1.7	-0.9
Cholesterol lowering medication	0.6	0.9	1.4	0.7	-0.8	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.2	-0.6	0.1	1.8
Pain experienced in last month	0.0	0.1	0.1	-0.0	0.3	-0.4
Supplements: Calcium	1.1	1.2	1.6	-1.3	0.7	-1.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.1	0.5	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.1	-0.5	0.4
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.3	-1.1	0.4	1.2
Heart disease (siblings)	0.7	0.8	1.4	-0.9	-1.2	-0.3
Alcohol drinker status: Previous	1.9	2.1	5.4	0.5	0.8	-2.3
Pack years of smoking	0.9	1.3	2.9	1.7	1.0	-0.2
Impedance of whole body	0.7	3.4	5.2	2.2	-2.3	-0.5
Leg fat mass (left)	0.4	1.6	4.0	0.6	-2.0	0.8
Arm predicted mass (left)	0.5	2.4	5.2	-1.2	2.3	-0.8