Hub : Genes

SLC1A2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0398 0.0166 4.8e-03 0.013 0.021 0.017 0.021 0.020 4.3e-03 3.5e-04 9.8e-04 3e-04 5.0e-04
2 TCGA Head and Neck Squamous Cell Carcinoma 0.0334 0.0179 7.5e-03 0.005 0.007 0.002 NA -0.002 9.0e-02 5.3e-02 2.0e-01 NA 6.3e-01
3 TCGA Prostate Adenocarcinoma 0.1490 0.0466 1.8e-05 0.090 0.060 0.077 NA 0.077 1.2e-09 7.0e-07 2.0e-08 NA 1.9e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.5 0.9 2.2 0.6 -0.3 -1.5
Bipolar Disorder or Schizophrenia 0.1 0.2 0.6 0.2 -0.8 -0.2
Depressed Affect (Nagel 2018) 0.1 0.3 0.6 -0.8 -0.2 -0.4
Depression (Nagel 2018) 0.3 0.4 0.6 -0.8 0.4 -0.6
Intelligence (Savage-Jansen 2018) 0.4 1.2 2.4 -0.8 1.6 -0.7
Neuroticism (Nagel 2018) 0.2 0.5 0.8 -0.9 -0.9 -0.0
Schizophrenia (2018) 0.2 0.5 0.8 -0.2 -0.8 0.9
Schizophrenia vs Biploar Disorder 0.8 1.1 2.0 1.4 0.9 0.7
Worry (Nagel 2018) 0.2 0.5 0.9 0.1 -0.7 -1.0
Alzheimer’s Disease (in mother) 0.7 0.8 1.2 -0.7 -1.1 0.8
Alzheimer’s Disease (in father) 0.4 0.4 0.7 0.8 -0.5 -0.6
Alzheimer’s Disease (including proxy) 0.4 0.5 1.5 0.3 -1.2 0.0
Crohns Disease (2017) 1.7 3.6 9.7 0.6 3.1 -1.0
Irritable Bowel Disease (IBD) 0.5 1.2 2.9 1.7 0.6 -0.5
Ulcerative Colitis (UC) 1.1 2.0 3.1 1.7 -1.8 0.1
Major Depression (MDD) 2.2 2.7 4.0 2.0 -1.0 1.7
Reaction Time 0.4 0.8 1.6 0.9 -1.3 -0.3
Verbal and Numeric Reasoning (VNR) 0.8 2.0 3.6 -1.4 1.9 -0.7
Breast Cancer 0.4 0.9 1.9 0.9 -0.3 1.4
Ovarian Cancer 0.4 0.5 1.0 1.0 -0.3 -0.7
Prostate Cancer 0.0 0.0 0.1 0.0 -0.2 0.0
Age at First Birth 0.2 0.3 0.8 -0.2 0.4 -0.9
Bipolar Disorder (2011) 1.5 1.5 3.7 -0.7 -0.4 -1.9
Body Mass Index (BMI) (2010) 0.7 0.9 1.6 1.0 -1.3 0.3
Coronary Artery Disease (CAD) 1.4 1.6 3.4 0.7 -1.8 1.0
Crohns Disease (2012) 0.4 0.7 2.0 -0.1 1.4 -0.1
Mean Putamen Volume 0.9 1.0 2.4 1.6 0.4 0.6
Fasting Glucose 0.6 0.7 0.8 0.7 -0.9 -0.9
HbA1C 0.7 0.8 2.3 0.4 0.1 1.5
HDL Cholesterol 1.5 2.6 5.7 2.4 -1.1 -1.0
LDL Cholesterol 1.4 2.2 5.6 -0.6 -2.4 -0.8
Lupus 0.1 0.1 0.2 0.5 0.2 -0.2
Neuroticism (2016) 0.8 1.1 1.4 0.9 1.0 -1.2
Primary Biliary Cirrhosis 0.0 0.0 0.0 0.2 -0.1 0.0
Rheumatoid Arthritis 1.3 1.7 3.5 1.3 -1.9 -0.4
Schizophrenia (2014) 0.1 0.2 0.4 0.6 -0.5 -0.1
Triglycerides 2.9 4.7 7.4 -2.7 -1.1 2.3
Type 2 Diabetes (T2D) (2012) 0.4 0.5 0.6 -0.8 -0.7 0.6
Ulcerative Colitis 1.6 2.4 4.9 1.0 -2.2 1.1
Blood Eosinophil Count 0.7 5.4 15.8 0.0 -4.0 0.6
Blood Platelet Count 0.3 3.9 11.4 -0.2 -3.4 0.3
Blood Red Count 0.2 1.8 1.9 1.4 -1.3 -1.4
Blood White Count 0.2 1.8 3.5 1.9 -0.5 -1.2
Heel T-Score 0.2 1.2 3.1 -0.7 1.8 -0.1
BMI 0.4 2.2 3.9 -1.2 -1.1 2.0
Height 0.4 7.2 15.5 1.0 3.9 -2.2
Waist Hip Ratio (WHR) 1.4 6.5 14.0 3.7 -2.3 -0.5
Systolic Blood Pressure 0.2 1.2 2.6 -0.9 0.1 1.6
Smoking Status 0.4 0.9 1.9 1.4 0.5 0.8
Allergy or Eczema 0.5 1.3 3.3 -0.7 -1.8 0.5
Cardiovascular Disease 0.1 0.3 0.9 0.3 -0.9 0.2
Hypothyroidism (self reported) 10.8 24.8 66.8 2.7 -8.2 -0.4
Respiratory disease 1.3 2.9 7.8 0.8 -0.6 2.8
Type 2 Diabetes (T2D) (2018) 1.1 2.1 6.1 -0.2 -2.5 -0.0
Lung FEV1/FVC ratio 2.1 10.9 22.6 -1.7 -4.7 -2.7
Lung FVC 0.2 1.1 1.3 -1.0 1.1 -1.0
Neuroticism 0.2 0.6 1.8 0.0 -0.1 -1.3
Chronotype (morning person) 0.2 0.6 1.3 -0.0 0.6 -1.2
Hair Pigment 0.1 3.7 9.3 -0.5 -3.0 1.2
Tanning 0.1 1.5 3.4 -0.8 -0.7 1.8
Hand grip strength (left) 1.4 3.8 11.1 -0.4 3.3 -0.4
Number of treatments/medications taken 0.8 1.4 3.2 1.8 -1.0 -0.0
Average weekly spirits intake 1.3 1.6 3.5 1.9 -0.6 0.9
Sensitivity / hurt feelings 0.5 0.8 1.6 -0.9 1.3 -0.3
Frequency of depressed mood in last 2 weeks 1.1 1.5 3.7 0.0 0.9 -1.9
Hearing difficulty/problems: Yes 0.4 0.6 1.5 0.5 -1.2 -0.2
Relative age of first facial hair 0.6 1.2 1.8 1.3 -0.6 1.2
Other serious medical condition/disability diagnosed by doctor 1.5 2.0 3.0 -0.6 -1.7 -1.6
Ever used hormone-replacement therapy (HRT) 1.0 1.2 2.5 1.6 0.9 0.7
Ever had hysterectomy (womb removed) 1.4 1.6 3.1 1.1 0.7 1.8
Systolic blood pressure, automated reading 0.6 1.8 3.3 -0.1 -1.5 1.8
Eye problems/disorders: Diabetes related eye disease 1.7 1.8 4.7 -2.2 -0.4 0.8
Angina 1.8 2.4 4.3 1.2 -2.1 -1.2
Medication for hormone replacement therapy 0.1 0.1 0.3 -0.0 -0.0 -0.6
Vitamin and mineral supplements 1.8 2.5 6.6 0.0 -2.6 1.0
Supplements: Zinc 0.0 0.0 0.1 0.2 -0.3 -0.2
Medication: Co-codamol 2.2 2.6 5.6 1.4 -0.2 -2.4
Medication: Metformin 0.2 0.3 1.0 -1.0 -0.1 -0.0
Diabetes (father) 0.9 1.2 2.2 -1.0 -0.4 1.5
Diabetes (mother) 3.0 3.8 11.3 0.2 -3.4 0.2
Severe depression (siblings) 2.8 3.1 6.9 0.2 -1.6 -2.6
Pack years adult smoking proportion 1.1 1.7 3.6 1.9 1.2 0.0
Impedance of leg (right) 0.7 3.4 5.3 2.3 -2.2 -0.0
Leg fat-free mass (left) 0.3 1.8 3.2 -1.0 1.8 -1.1
Trunk fat percentage 0.9 3.7 9.2 1.4 -3.0 -0.0
Hand grip strength (right) 1.2 3.2 8.5 -0.9 2.9 -0.5
Townsend deprivation index at recruitment 0.4 0.6 1.0 0.6 0.7 1.0
Current tobacco smoking 0.1 0.1 0.3 0.5 -0.1 0.1
Average weekly fortified wine intake 0.2 0.3 0.6 0.5 -0.8 -0.1
Maternal smoking around birth 1.5 2.2 3.8 0.7 -1.9 1.5
Fed-up feelings 0.3 0.5 1.1 -1.0 0.4 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.7 0.3 0.8 -0.4
Relative age voice broke 0.8 1.3 2.6 -1.6 0.0 1.1
Taking other prescription medications 2.1 3.2 9.3 0.6 -3.0 -0.2
Age when periods started (menarche) 0.1 0.2 0.2 0.4 -0.5 0.3
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 4.1 0.0 -0.3 2.0
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 1.8 -0.1 0.7 -1.3
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.4 0.8 1.2 0.7
Qualifications: CSEs or equivalent 0.2 0.3 0.8 0.3 -0.9 0.2
Serious illness, injury or assault to yourself 0.3 0.3 0.9 0.1 0.4 -0.9
High blood pressure 0.3 0.9 1.3 0.8 -1.1 0.9
Hayfever, allergic rhinitis or eczema 1.1 2.4 6.7 -0.7 -2.6 -0.0
Multivitamins +/- minerals 1.4 1.7 3.1 -0.6 1.8 -1.4
Stomach or abdominal pain in last month 0.2 0.3 0.9 -0.0 -0.0 -0.9
Supplements: Glucosamine 1.0 1.3 2.0 1.4 -0.3 -1.4
Diverticular disease/diverticulitis (self-reported) 2.3 2.7 4.5 -1.8 -2.1 0.6
Medication: Atenolol 0.0 0.0 0.0 -0.2 -0.1 -0.1
Medication: Levothyroxine sodium 12.1 20.5 55.3 2.5 -7.4 -0.1
Sitting height 0.6 4.1 9.7 -1.4 3.1 -0.9
Chronic bronchitis/emphysema (father) 1.6 1.9 5.1 0.5 -0.5 -2.2
High blood pressure (mother) 2.9 4.1 10.5 3.2 -1.3 -0.4
Body mass index (BMI) 0.2 1.0 2.6 -0.4 -1.6 0.4
Impedance of leg (left) 0.5 2.2 3.5 1.7 -1.9 0.5
Leg predicted mass (left) 0.3 1.7 3.1 -0.9 1.8 -1.2
Trunk fat mass 0.3 1.5 3.5 1.0 -1.9 -0.1
Waist circumference 0.3 1.0 2.5 0.6 -1.6 0.1
Number of incorrect matches in round 0.4 0.7 1.1 1.1 -0.2 1.0
Past tobacco smoking 0.5 1.0 2.0 0.7 -0.7 -1.4
Alcohol usually taken with meals 1.6 2.5 3.5 -1.9 1.8 -0.9
Nervous feelings 0.6 1.1 2.6 0.6 0.5 -1.6
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.7 5.2 -0.6 2.3 -1.6
Hearing difficulty/problems with background noise 0.3 0.5 1.0 1.0 -0.2 0.7
Hair/balding pattern: Pattern 2 0.4 0.5 0.7 0.7 -0.8 0.4
Had menopause 1.1 1.4 2.2 0.1 1.5 -1.4
Had other major operations 0.7 0.9 1.7 -1.3 0.9 -0.2
Forced vital capacity (FVC) 0.6 2.5 5.8 -1.0 2.4 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.3 -1.1 0.2 -0.3
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.2 1.0 -0.9 1.1
Qualifications: None of the above 0.7 1.5 2.1 1.5 -1.1 1.0
Financial difficulties in last 2 years 0.2 0.2 0.4 0.3 -0.7 -0.4
Mouth/teeth dental problems 0.8 1.2 2.9 -0.4 0.6 -1.7
Heart attack 0.2 0.3 0.6 0.2 -0.5 0.8
Allergy 0.9 2.2 5.0 0.6 2.2 -1.1
Pain all over the body in last month 0.8 0.8 2.0 -0.2 -1.4 0.7
Diabetes (self-reported) 0.9 1.3 2.8 -0.9 -1.7 0.6
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.4 0.2 -0.5 -0.6
Medication: Ramipril 0.7 1.0 2.2 0.6 0.5 1.5
Medication: Simvastatin 0.5 0.8 2.2 0.2 -1.5 -0.3
Fluid intelligence score 0.3 0.6 1.4 -0.6 1.2 -0.1
Illnesses of siblings 0.7 1.0 2.1 -0.1 1.4 -1.0
Neuroticism score 0.3 0.6 1.7 -0.2 -0.1 -1.3
Weight 0.0 0.1 0.2 -0.2 0.2 -0.5
Impedance of arm (right) 1.5 6.9 10.0 3.1 -3.2 -1.2
Arm fat percentage (right) 1.3 5.2 14.3 1.1 -3.8 0.3
Trunk fat-free mass 0.7 4.0 9.9 -1.2 3.1 -0.8
Hip circumference 0.1 0.3 0.4 -0.6 -0.7 -0.1
Time employed in main current job 1.7 1.9 4.8 -2.2 0.8 0.5
Alcohol intake versus 10 years previously 0.3 0.5 1.2 0.4 -1.1 -0.2
Father’s age at death 0.4 0.5 0.8 0.5 0.7 -0.9
Worrier / anxious feelings 0.1 0.1 0.3 0.3 0.6 0.0
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.3 1.2 -0.9 -0.3
Falls in the last year 0.6 0.8 1.9 1.4 -0.7 0.3
Hair/balding pattern: Pattern 3 0.8 1.2 2.2 -0.3 1.5 -1.2
Number of live births 0.2 0.3 0.8 0.4 -0.1 0.9
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 2.9 -1.7 0.7 -1.5
Pulse rate 0.2 0.4 0.7 0.4 0.8 0.6
Happiness 0.0 0.1 0.2 -0.4 -0.0 -0.0
Noisy workplace 0.1 0.1 0.4 0.2 0.1 0.6
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.1 -1.1 0.3 -0.9
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 2.0 -0.7 1.1 -1.4
Mouth/teeth dental problems: Dentures 0.4 0.6 1.3 0.6 1.1 0.4
Asthma 1.0 1.9 4.8 -0.1 -1.0 2.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.1 -1.0 -0.4 0.3
Medication: Cholesterol lowering 0.4 0.6 1.5 -0.6 -1.2 0.2
Depression (self-reported) 1.5 1.8 4.8 0.5 0.6 -2.2
Medication: Lansoprazole 1.0 1.2 3.4 -0.1 -1.9 -0.2
Prospective memory result 0.9 1.1 2.7 1.7 0.1 -0.8
Lung cancer (father) 0.2 0.3 0.4 -0.6 -0.1 0.6
Illnesses of mother 2.3 2.9 7.0 -2.6 1.3 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 2.3 -1.0 0.1 -1.5
Pulse wave Arterial Stiffness index 1.0 1.1 1.5 1.0 -1.0 -1.2
Impedance of arm (left) 0.9 4.1 6.7 2.2 -2.6 -0.8
Arm fat mass (right) 0.4 1.5 4.1 0.6 -2.0 0.1
Trunk predicted mass 0.7 3.9 9.8 -1.1 3.1 -0.8
Standing height 0.7 6.5 14.4 0.3 3.8 -2.2
Length of working week for main job 1.1 1.2 1.7 0.7 -1.3 -1.2
Exposure to tobacco smoke at home 0.4 0.5 0.9 0.5 -1.0 0.5
Breastfed as a baby 0.3 0.4 0.9 0.5 0.9 -0.4
Tense / ‘highly strung’ 2.4 4.0 9.5 -0.5 1.5 -3.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.1 3.9 1.5 -0.0 -2.0
Hair/balding pattern: Pattern 4 0.4 0.9 2.7 -1.6 0.1 -0.1
Birth weight of first child 0.1 0.2 0.4 -0.7 0.2 -0.4
Peak expiratory flow (PEF) 0.3 0.6 1.1 -1.1 -0.1 -0.9
Pulse wave reflection index 0.1 0.1 0.3 -0.5 -0.2 -0.0
Ever highly irritable/argumentative for 2 days 0.6 0.8 2.1 1.4 -0.0 0.5
Loud music exposure frequency 1.3 1.4 2.7 0.8 -1.6 1.0
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 4.5 -2.1 0.4 0.7
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.5 -0.4 -1.2 1.1
Blood clot in the leg (DVT) 0.5 0.6 1.1 -0.8 0.3 1.1
Medication: Paracetamol 0.6 1.1 2.8 1.7 -0.1 0.6
Headache pain in last month 0.8 1.4 2.7 0.4 1.1 1.6
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.5 0.3 0.7 0.1
Glaucoma (self-reported) 1.8 2.2 6.0 -0.3 2.5 -0.6
Gout (self-reported) 0.3 0.4 1.2 -1.1 -0.0 -0.1
Hypothyroidism/myxoedema (self-reported) 11.4 22.2 62.1 2.2 -7.9 0.1
Medication: Amlodipine 1.8 2.5 3.0 -1.4 1.6 1.7
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.6 -1.3 -0.3 -0.6
Birth weight 1.0 2.1 5.6 0.8 2.4 -0.4
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.1 -0.6 1.1 0.2
High blood pressure (siblings) 1.5 2.1 4.5 -0.1 -2.1 1.3
Forced vital capacity (FVC), Best measure 0.3 1.1 1.8 -0.4 1.3 -1.1
Body fat percentage 1.2 4.7 12.2 1.3 -3.5 0.5
Leg fat percentage (right) 1.6 5.9 14.0 1.5 -3.7 1.2
Arm fat-free mass (right) 0.8 4.1 8.3 -2.0 2.9 -0.4
Exposure to tobacco smoke outside home 2.0 2.7 7.6 2.8 -0.6 0.1
Comparative body size at age 10 0.2 0.6 1.3 -1.1 0.2 -0.6
Number of full brothers 2.1 2.6 4.0 2.0 -1.9 -0.6
Worry too long after embarrassment 0.3 0.5 0.9 -0.8 1.0 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 1.0 2.4 0.4 0.6 -1.6
Wheeze or whistling in the chest in last year 1.1 1.9 2.6 1.6 -0.8 1.6
Number of children fathered 0.8 0.9 1.7 0.8 0.6 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.2 1.1 -0.1 -0.3
Age at first live birth 0.3 0.6 1.7 -0.0 1.3 0.2
Pulse wave peak to peak time 0.8 1.0 1.4 -0.7 1.2 1.0
Health satisfaction 0.4 0.5 1.0 0.6 -1.0 -0.3
Shortness of breath walking on level ground 1.2 1.4 3.8 -2.0 0.6 0.0
Qualifications: College or University degree 0.4 1.2 2.7 0.2 0.9 -1.6
Eye problems/disorders: None of the above 0.4 0.4 1.1 0.1 0.3 -1.1
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.7 -0.0 -0.0 0.8
Emphysema/chronic bronchitis 0.9 1.1 3.0 1.7 -0.4 -0.1
Medication for pain relief, constipation, heartburn 0.5 0.8 0.9 -1.0 0.8 -0.9
Neck or shoulder pain in last month 0.7 1.1 2.7 1.6 -0.7 0.1
Medication: Blood pressure 0.3 0.5 1.6 0.2 -1.2 -0.1
Angina (self-reported) 2.1 2.7 4.8 1.4 -2.2 -1.1
Migraine (self-reported) 1.0 1.3 2.1 1.4 0.4 -1.2
Medication: Ibuprofen 0.2 0.2 0.3 -0.5 -0.2 -0.6
Medication: Allopurinol 0.1 0.1 0.2 -0.5 -0.3 -0.1
Medication: Omeprazole 0.6 0.8 2.3 0.0 0.0 1.5
Medication: Seretide 50 evohaler 1.3 1.5 2.8 -0.9 -1.7 0.9
Mean time to correctly identify matches 1.2 2.2 3.1 1.8 -1.5 -1.1
Heart disease (mother) 0.7 0.8 2.4 1.6 0.0 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.0 0.0 0.7 -1.0
Whole body fat mass 0.4 1.7 4.1 0.9 -2.0 0.1
Leg fat mass (right) 0.5 2.0 4.9 0.7 -2.2 0.7
Arm predicted mass (right) 0.6 2.9 6.4 -1.5 2.5 -0.3
Pulse rate, automated reading 0.3 1.1 1.7 -1.0 1.3 0.7
Alcohol intake frequency. 0.4 0.9 1.7 0.9 -0.1 -1.3
Comparative height size at age 10 0.7 3.8 9.2 -0.6 3.0 -1.3
Number of full sisters 1.1 1.3 3.6 0.2 -1.9 -0.5
Suffer from ‘nerves’ 0.6 0.9 2.6 0.3 -1.6 -0.1
Overall health rating 0.6 1.4 2.4 1.2 -1.6 -0.3
Chest pain or discomfort 0.5 0.7 1.3 1.2 -0.7 0.3
Had major operations 0.1 0.1 0.2 0.4 0.3 0.4
Age at last live birth 0.3 0.4 0.6 0.6 0.8 -0.6
Family relationship satisfaction 0.9 1.2 2.5 1.6 -0.8 0.6
Leg pain on walking 1.0 1.3 3.3 0.5 1.8 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.2 1.5 -1.0 0.0
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.0 0.5 -0.8 1.0
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 4.1 0.0 -0.0 2.0
Medication: Aspirin 1.1 1.5 2.5 1.4 -1.6 0.3
Supplements: Vitamin C 0.3 0.3 0.9 -0.1 0.9 -0.3
Knee pain experienced in last month 0.5 0.8 1.9 -1.4 0.5 -0.4
Hypertension (Self-reported) 0.3 0.8 1.7 0.3 -1.3 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 0.9 0.9 1.0 -0.2
Illnesses of father: Heart disease 0.1 0.1 0.2 0.1 0.4 0.0
Illnesses of siblings: Diabetes 0.6 0.7 1.0 0.8 -0.7 -1.0
Smoking status: Previous 0.4 0.5 1.2 -0.1 0.6 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.4 0.5 0.9 -1.2
Whole body fat-free mass 0.6 3.2 7.1 -1.3 2.7 -0.9
Leg fat-free mass (right) 0.5 2.7 4.9 -1.4 2.2 -1.1
Arm fat percentage (left) 1.1 4.5 12.8 0.6 -3.6 0.6
Average weekly red wine intake 2.0 3.0 6.2 -0.9 2.5 -1.4
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 0.2 0.0 0.1
Mood swings 0.1 0.3 0.4 -0.1 -0.6 -0.6
Loneliness, isolation 0.4 0.6 1.5 -0.2 0.4 -1.2
Long-standing illness, disability or infirmity 1.3 2.0 4.3 -1.2 -2.1 0.5
Ever had bowel cancer screening 1.1 1.2 2.2 1.5 0.8 0.9
Diabetes diagnosed by doctor 1.4 2.3 5.7 -0.6 -2.4 0.9
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 4.9 0.2 -2.2 0.6
Friendships satisfaction 0.7 0.9 2.4 1.6 -0.2 0.3
Qualifications: nursing, teaching 0.3 0.4 1.1 0.4 -0.2 -1.0
Commuting to job workplace: Walk 0.2 0.3 0.5 -0.4 -0.7 -0.4
Eye problems/disorders: Cataract 0.2 0.2 0.5 -0.1 0.0 0.7
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 2.2 0.3 -1.4 1.5
Medication for cholesterol 0.0 0.0 0.1 -0.2 0.3 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.1 0.8 -0.5 -1.0
Back pain experienced in last month 0.1 0.1 0.2 -0.0 0.4 -0.3
Mineral and other dietary supplements 0.8 1.1 2.5 0.7 -1.6 0.6
Breast cancer (self-reported) 2.0 2.4 4.8 -0.6 2.2 -1.5
Asthma (self-reported) 1.1 2.1 5.1 -0.1 -1.2 2.2
Osteoporosis (self-reported) 0.0 0.0 0.0 -0.0 0.2 0.1
Osteoarthritis (self-reported) 2.1 2.7 4.9 2.2 -1.3 -1.2
Medication: Aspirin 0.8 1.0 2.1 1.0 -1.4 0.1
Medication: Gliclazide 0.4 0.5 0.9 -0.7 0.1 -0.9
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 -0.6 -0.4 -0.3
Smoking status: Current 0.0 0.0 0.0 0.1 -0.1 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 2.9 -1.5 -0.2 -1.7
Whole body water mass 0.6 3.5 7.8 -1.4 2.8 -0.9
Leg predicted mass (right) 0.5 2.7 5.0 -1.4 2.2 -1.1
Arm fat mass (left) 0.3 1.0 3.1 0.1 -1.8 0.1
Number of self-reported non-cancer illnesses 1.6 2.8 6.9 1.2 -2.6 -0.4
Average weekly champagne plus white wine intake 0.1 0.2 0.4 0.7 0.2 0.3
Miserableness 0.2 0.4 0.8 0.9 -0.5 -0.3
Guilty feelings 0.8 1.2 3.2 0.7 -1.8 -0.3
Wears glasses or contact lenses 1.0 1.2 2.4 1.6 1.1 -0.2
Ever taken oral contraceptive pill 0.6 0.6 1.2 0.4 0.8 -1.1
Hearing aid user 1.7 2.0 4.0 -1.1 2.0 0.8
Mother’s age at death 1.2 1.5 3.1 1.0 -0.8 -1.8
Financial situation satisfaction 1.6 2.0 5.0 0.2 -0.9 2.2
Tinnitus: Yes, now most or all of the time 1.1 1.3 3.1 -0.3 -0.8 1.8
Commuting to job workplace: Public transport 0.2 0.2 0.4 -0.6 0.3 0.3
Eye problems/disorders: Glaucoma 1.5 1.8 5.4 0.1 2.3 0.1
Medication: Blood pressure 0.5 0.9 2.0 0.8 0.4 1.4
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.8 0.6 0.9 0.3
Supplements: Fish oil (including cod liver oil) 2.0 2.6 3.9 -1.8 2.0 0.8
High cholesterol (Self-reported) 0.0 0.1 0.2 -0.1 -0.4 -0.2
Medication: Bendroflumethiazide 0.4 0.7 1.6 0.6 -0.3 1.3
Medication: Paracetamol 1.3 2.1 6.0 2.5 0.3 -0.4
Medication: Lisinopril 1.9 2.5 4.5 -1.2 -2.1 1.2
Medication: Atorvastatin 0.1 0.2 0.4 -0.1 0.2 -0.6
Illnesses of father: High blood pressure 0.7 0.8 1.2 0.8 0.9 1.1
Alcohol drinker status: Never 1.8 2.2 4.8 -0.0 -2.2 1.3
Ever smoked 0.7 1.2 3.0 -0.8 0.3 1.7
Basal metabolic rate 0.4 2.1 4.4 -1.1 2.1 -0.9
Leg fat percentage (left) 1.4 5.1 12.0 1.2 -3.5 1.4
Arm fat-free mass (left) 0.5 2.3 5.2 -1.2 2.3 -0.3
Number of operations (self-reported) 0.1 0.1 0.3 -0.6 -0.1 0.2
Average weekly beer plus cider intake 1.3 1.9 4.8 -0.4 -2.2 0.9
Irritability 0.0 0.0 0.1 0.1 -0.4 0.0
Risk taking 0.3 0.4 0.7 0.2 -0.7 -0.9
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.1 -0.2 0.2 0.4
Fractured/broken bones in last 5 years 3.1 4.1 11.5 -3.4 -0.2 0.8
Age started oral contraceptive pill 0.1 0.1 0.2 -0.1 -0.4 0.1
Diastolic blood pressure, automated reading 1.0 3.0 6.7 0.1 -2.6 1.6
Ever depressed for a whole week 0.1 0.2 0.4 0.6 0.2 0.1
Unable to work because of sickness or disability 1.1 1.5 4.2 -0.3 0.5 -2.0
Commuting to job workplace: Cycle 0.5 0.6 1.1 0.7 0.4 -1.1
Myopia 0.2 0.4 0.8 -0.9 -0.4 0.3
Vascular/heart problems diagnosed by doctor 0.6 1.7 2.8 -1.2 1.7 -0.9
Cholesterol lowering medication 0.6 0.9 1.4 0.7 -0.8 -1.2
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 3.2 -0.6 0.1 1.8
Pain experienced in last month 0.0 0.1 0.1 -0.0 0.3 -0.4
Supplements: Calcium 1.1 1.2 1.6 -1.3 0.7 -1.3
Basal cell carcinoma (self-reported) 0.1 0.1 0.3 -0.1 0.5 0.4
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 0.1 -0.5 0.4
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 1.3 -1.1 0.4 1.2
Heart disease (siblings) 0.7 0.8 1.4 -0.9 -1.2 -0.3
Alcohol drinker status: Previous 1.9 2.1 5.4 0.5 0.8 -2.3
Pack years of smoking 0.9 1.3 2.9 1.7 1.0 -0.2
Impedance of whole body 0.7 3.4 5.2 2.2 -2.3 -0.5
Leg fat mass (left) 0.4 1.6 4.0 0.6 -2.0 0.8
Arm predicted mass (left) 0.5 2.4 5.2 -1.2 2.3 -0.8