TWAS hub - IL15RA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.2260	0.0560	0.00011	0.066	NA	0.087	NA	0.086	1.0e-06	NA	2.0e-08	NA	2.6e-08
2	NTR	Blood	0.0357	0.0140	0.00560	0.002	0.008	0.011	0.011	0.003	7.7e-02	0.00068	1.2e-04	0.00015	3.2e-02
3	YFS	Blood	0.0385	0.0145	0.00490	0.005	0.004	0.007	0.007	0.006	4.9e-03	0.01200	1.5e-03	0.00180	3.1e-03
4	TCGA	Brain Lower Grade Glioma	0.0805	0.0318	0.00058	0.016	0.036	0.009	NA	0.009	5.2e-03	0.00006	2.6e-02	NA	3.2e-02
5	TCGA	Prostate Adenocarcinoma	0.0430	0.0207	0.00530	0.002	0.009	-0.002	NA	0.006	1.9e-01	0.03500	5.3e-01	NA	7.2e-02
6	TCGA	Thyroid Carcinoma	0.0560	0.0250	0.00560	0.002	0.036	0.004	NA	-0.001	2.1e-01	0.00018	1.1e-01	NA	3.7e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Illnesses of siblings: Diabetes	4.5	5.5	10.5	2.3	-1.0	2.0	1.6	3.2	3.1
Medication: Levothyroxine sodium	4.1	7.0	30.7	0.0	0.2	0.6	1.8	5.5	2.8
Reason for reducing amount of alcohol drunk: Health precaution	3.6	4.2	8.5	2.6	0.1	2.9	2.9	1.2	-0.4
Pack years adult smoking proportion	3.0	4.5	15.4	-0.9	-0.9	-0.1	-0.4	-3.2	-3.9
Pack years of smoking	2.9	4.2	14.6	-0.8	-1.2	0.1	-0.1	-2.9	-3.8
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	5.7	1.2	0.2	2.4	2.0	2.1	1.0
Hypothyroidism/myxoedema (self-reported)	2.6	5.0	21.5	0.2	-0.5	-0.1	0.0	4.6	2.9
Hypothyroidism (self reported)	2.4	5.5	21.0	0.4	-0.4	-0.9	-0.4	4.6	3.3
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	7.1	0.9	-2.2	0.5	1.4	2.7	1.4
Mouth/teeth dental problems	2.3	3.5	7.3	1.5	1.4	1.2	1.9	2.1	2.7
Mouth/teeth dental problems: Mouth ulcers	2.3	3.7	13.4	-0.5	0.4	-0.4	-0.4	-2.9	-3.7
Breastfed as a baby	2.2	2.8	5.1	1.6	1.2	2.2	1.5	2.3	0.5
Medication: Omeprazole	2.2	2.6	6.9	-0.5	-0.2	-1.3	-0.5	-2.6	-2.5
Supplements: Zinc	2.1	2.2	3.8	1.4	-0.9	1.2	1.4	1.9	1.8
Medication: Gliclazide	2.0	2.3	5.8	2.4	-1.0	1.0	0.7	1.8	1.5
Wheeze or whistling in the chest in last year	1.9	3.5	6.2	1.2	-1.5	1.9	1.5	2.3	2.5
Taking other prescription medications	1.8	2.8	7.6	0.6	-1.1	-0.3	0.2	2.8	2.7
Loud music exposure frequency	1.8	2.0	3.7	0.8	0.6	0.8	1.9	1.8	1.8
Blood clot in the leg (DVT)	1.8	2.3	7.8	0.4	-0.0	-0.4	0.2	-2.4	-2.8
Lung cancer (father)	1.7	2.0	3.5	1.3	-0.9	1.8	1.0	1.9	1.2
Chronic bronchitis/emphysema (mother)	1.7	2.0	7.8	1.1	0.5	0.4	2.8	1.3	1.0
Alcohol intake frequency.	1.7	3.8	8.1	-2.4	-1.6	-0.8	-2.9	-2.1	-1.1
Commuting to job workplace: Car/motor vehicle	1.7	1.9	3.3	1.6	1.0	1.2	0.1	1.8	1.8
Eye problems/disorders: Cataract	1.7	2.0	3.8	1.5	-0.6	1.5	1.9	1.7	0.8
Medication: Atorvastatin	1.7	2.1	2.9	-1.1	1.5	-1.0	1.5	-1.7	-1.7
Pain all over the body in last month	1.6	1.7	3.8	-2.0	-1.0	-1.5	-1.4	-0.7	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	6.1	1.7	-1.3	-2.5	-0.6	0.3	-0.1
Pulse wave reflection index	1.6	2.0	3.6	0.5	-0.6	1.9	1.8	1.5	1.6
Headache pain in last month	1.6	2.8	8.6	1.8	-1.1	0.6	2.9	1.8	0.6
Leg pain on walking	1.6	2.0	5.2	0.3	-0.9	-0.0	-1.2	2.1	2.3
Mother’s age at death	1.6	2.0	4.6	-1.7	-1.4	0.2	-2.2	-0.9	-1.2
High cholesterol (Self-reported)	1.6	2.9	7.5	1.0	1.8	1.9	2.7	1.2	0.8
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	7.3	0.2	-0.0	-0.2	0.5	-2.1	-2.7
Bipolar Disorder (2018)	1.5	2.3	6.2	0.9	0.9	1.1	2.5	-1.6	-1.5
Asthma	1.5	3.0	8.5	0.9	-0.6	-0.5	2.2	1.7	2.9
Medication: Allopurinol	1.5	2.0	3.7	0.5	-1.8	-1.1	-1.2	1.6	1.9
Asthma (self-reported)	1.5	2.9	9.3	0.8	-0.7	-0.4	2.0	1.8	3.0
Alzheimer’s Disease (including proxy)	1.4	2.0	3.9	-1.5	0.7	0.6	-1.4	2.0	1.7
Primary Biliary Cirrhosis	1.4	2.0	7.1	-0.7	0.8	-1.6	0.1	-2.7	-1.1
Respiratory disease	1.4	3.1	11.6	0.8	-1.2	-0.1	0.8	2.0	3.4
Serious illness, injury or assault to yourself	1.4	1.8	3.8	1.3	2.0	0.8	0.3	1.2	1.7
Worrier / anxious feelings	1.4	2.7	7.5	-0.5	1.1	-1.0	-1.2	-2.7	-2.1
Age at last live birth	1.4	2.0	6.4	0.3	-0.1	-1.5	0.4	1.9	2.5
Handedness (chirality/laterality): Left-handed	1.4	1.7	5.0	0.8	0.8	-1.7	0.2	-1.0	-2.2
Wears glasses or contact lenses	1.4	1.6	5.5	-0.3	-0.2	-1.0	0.0	2.3	1.7
Ever had prostate specific antigen (PSA) test	1.4	1.6	4.8	-1.6	0.4	-2.2	0.3	-1.0	-1.1
Commuting to job workplace: Cycle	1.4	1.7	4.4	0.3	-0.9	-0.5	1.0	-1.9	-2.1
Age at First Birth	1.3	1.9	5.0	1.9	0.4	2.2	0.7	1.2	0.7
Mean Putamen Volume	1.3	1.4	3.3	1.8	-1.4	-0.8	-0.1	-0.8	-1.5
Rheumatoid Arthritis	1.3	1.9	4.7	-1.3	-1.2	-1.8	-2.2	0.2	-0.3
Ever highly irritable/argumentative for 2 days	1.3	1.6	6.7	0.7	-0.0	0.7	2.6	0.8	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	4.7	-0.9	1.1	-1.5	-2.2	-0.2	0.7
Commuting to job workplace: Public transport	1.3	1.6	6.2	-1.6	-2.5	-0.1	0.6	-0.4	-0.2
Alcohol drinker status: Never	1.3	1.5	5.3	0.2	-2.3	0.7	-1.5	0.2	0.9
Hayfever, allergic rhinitis or eczema	1.2	2.7	10.4	1.1	0.4	-1.8	-0.9	-0.2	3.2
Tense / ‘highly strung’	1.2	2.1	7.6	1.1	0.0	0.6	2.8	-0.5	-1.7
Emphysema/chronic bronchitis	1.2	1.4	3.4	0.2	-0.1	1.8	-0.9	1.2	1.6
Number of full sisters	1.2	1.5	2.7	1.1	-1.1	1.2	0.9	1.1	1.6
Family relationship satisfaction	1.2	1.4	2.8	0.4	-1.7	0.4	1.5	1.5	1.1
Friendships satisfaction	1.2	1.4	3.0	0.8	-1.3	1.1	1.4	1.7	0.2
Severe depression (siblings)	1.1	1.2	3.2	1.1	-0.1	-1.0	0.4	-1.3	-1.8
Medication: Ramipril	1.1	1.5	3.5	-1.3	0.4	0.5	1.9	1.5	0.9
Gout (self-reported)	1.1	1.5	3.9	0.8	-2.0	-0.5	-0.6	1.3	1.4
Migraine (self-reported)	1.1	1.3	3.5	1.5	0.8	1.0	1.9	0.7	-0.1
Smoking status: Previous	1.1	1.6	5.2	0.0	2.0	-2.3	-0.8	-0.3	-0.1
Ever had bowel cancer screening	1.1	1.3	5.1	-1.3	-0.8	-2.3	-0.3	-0.3	-0.6
Diabetes diagnosed by doctor	1.1	1.8	3.6	0.8	1.0	1.5	0.8	1.7	1.9
Medication: Lisinopril	1.1	1.4	5.2	2.3	-0.1	1.1	0.4	1.4	0.5
Cholesterol lowering medication	1.1	1.7	8.3	-0.6	-0.4	0.2	2.9	0.9	0.5
Supplements: Calcium	1.1	1.2	3.4	0.8	-0.6	1.2	-0.2	1.8	1.1
Crohns Disease (2017)	1.0	2.3	4.0	2.0	1.0	-0.5	1.9	1.0	2.0
Lupus	1.0	1.5	3.5	0.7	0.1	1.6	1.9	1.5	0.4
Allergy or Eczema	1.0	2.6	7.8	0.6	1.0	-2.3	-0.8	-0.5	2.8
Sensitivity / hurt feelings	1.0	1.7	3.8	-1.5	-0.8	-1.0	-0.2	-2.0	-1.5
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.0	-0.5	0.5	1.5	0.6	1.7	1.3
Qualifications: CSEs or equivalent	1.0	1.4	2.9	1.1	-1.7	-0.4	-1.3	0.8	1.3
Alcohol usually taken with meals	1.0	1.6	5.2	0.8	-2.3	1.5	0.4	0.7	-0.8
Diabetes (self-reported)	1.0	1.5	2.7	0.7	1.1	1.4	0.9	1.4	1.6
Noisy workplace	1.0	1.2	3.4	-1.9	0.5	-0.2	-1.3	-1.4	-0.1
Exposure to tobacco smoke outside home	1.0	1.4	4.7	-1.0	-0.6	-0.7	0.1	-1.3	-2.2
Age at first live birth	1.0	1.8	4.5	1.4	0.4	-1.4	-0.2	1.5	2.1
Illnesses of father: Heart disease	1.0	1.4	3.0	1.2	0.6	0.6	1.7	-0.6	-1.7
Commuting to job workplace: Walk	1.0	1.0	2.7	1.0	-1.1	0.8	-0.4	0.8	1.6
Tinnitus: Yes, now most or all of the time	1.0	1.2	4.7	0.5	2.2	-0.8	-0.9	-0.8	0.1
Breast Cancer	0.9	2.1	6.4	1.4	2.5	1.2	1.5	0.3	0.6
HbA1C	0.9	0.9	4.8	-0.1	-2.2	0.7	0.3	-0.1	-0.5
Schizophrenia (2014)	0.9	2.1	5.5	2.3	-0.2	2.1	1.3	0.9	-0.1
Waist Hip Ratio (WHR)	0.9	4.1	6.6	2.5	1.5	1.8	1.2	2.6	2.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.4	0.8	1.3	0.7	1.6	1.3	-0.2
Medication: Metformin	0.9	1.2	2.0	0.5	1.4	0.7	1.3	1.4	1.1
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	4.2	-0.2	0.4	-0.1	-0.8	1.4	2.1
Medication: Simvastatin	0.9	1.4	3.4	-0.8	0.6	1.9	1.6	0.8	0.8
Happiness	0.9	1.1	2.5	0.7	-1.4	0.7	1.0	1.6	-0.3
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.0	-0.1	-1.6	-2.0	-1.2	-0.7	-0.7
Long-standing illness, disability or infirmity	0.9	1.4	6.0	-0.2	-0.3	-0.4	0.1	1.4	2.4
Osteoarthritis (self-reported)	0.9	1.2	4.7	-2.2	-0.8	-0.7	0.1	-1.0	-0.7
Guilty feelings	0.9	1.4	5.0	0.2	-0.4	0.4	0.6	-1.6	-2.2
Ever smoked	0.9	1.5	3.8	1.2	1.9	-1.6	1.1	-0.4	-0.3
Ever depressed for a whole week	0.9	1.1	3.0	-1.0	-0.0	0.5	1.2	1.7	0.8
Unable to work because of sickness or disability	0.9	1.2	2.4	-1.2	1.1	0.9	-0.3	1.1	1.6
Basal cell carcinoma (self-reported)	0.9	1.1	2.6	0.6	1.6	-1.2	1.2	0.2	-0.9
Schizophrenia vs Biploar Disorder	0.8	1.1	4.2	-1.1	-2.0	0.0	-0.8	0.7	-0.2
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.4	0.7	-0.4	1.6	1.2	0.9	0.5
Ulcerative Colitis	0.8	1.1	2.7	-0.3	1.6	-0.3	-0.9	-1.3	-1.2
Ever had hysterectomy (womb removed)	0.8	0.9	2.8	1.1	-0.0	1.7	1.0	0.6	-0.2
Townsend deprivation index at recruitment	0.8	1.2	2.5	-0.7	1.0	-0.8	-1.6	-1.3	0.8
Allergy	0.8	1.8	6.9	-1.4	-0.0	1.4	-0.4	-0.2	-2.6
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.9	-0.3	-1.9	-1.1	-2.0	-1.0	-1.0
Mouth/teeth dental problems: Dentures	0.8	1.4	3.8	-0.7	-1.6	-0.6	-1.9	-0.6	-0.8
Medication: Cholesterol lowering	0.8	1.3	5.0	-0.2	2.2	1.1	1.2	0.3	0.4
Shortness of breath walking on level ground	0.8	1.0	1.7	1.0	-1.0	-0.4	-1.3	0.8	1.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.7	-1.2	-1.3	-0.8	-0.3	-1.2	-0.7
Supplements: Vitamin C	0.8	0.9	3.2	1.4	0.3	1.8	0.6	0.4	-0.2
Breast cancer (self-reported)	0.8	1.0	3.1	1.4	0.3	0.2	0.1	1.8	0.8
Ever taken oral contraceptive pill	0.8	0.9	3.0	-0.9	0.4	-0.8	-1.7	-0.3	0.9
Bipolar Disorder or Schizophrenia	0.7	1.8	4.2	2.0	-0.3	1.2	1.9	-0.3	-1.1
Alzheimer’s Disease (in mother)	0.7	0.8	3.7	-0.4	0.5	0.1	-1.9	0.4	0.7
Verbal and Numeric Reasoning (VNR)	0.7	1.7	6.5	2.6	-0.7	0.4	1.2	1.2	0.4
Body Mass Index (BMI) (2010)	0.7	0.9	3.8	1.0	0.1	0.2	-0.3	0.7	2.0
Hand grip strength (left)	0.7	1.7	5.2	-1.4	-1.1	-0.6	-2.3	-1.3	-0.5
Hearing difficulty/problems: Yes	0.7	1.1	2.9	0.9	1.7	0.9	0.7	1.0	0.7
Diabetes (father)	0.7	0.9	3.0	1.7	-1.1	-0.8	0.4	-0.5	0.2
Average weekly fortified wine intake	0.7	0.8	2.5	-1.6	0.9	-0.4	-0.8	0.4	0.6
Maternal smoking around birth	0.7	1.0	4.8	-0.3	0.3	2.2	0.3	0.0	1.0
Stomach or abdominal pain in last month	0.7	0.8	1.7	-0.8	0.3	0.9	0.8	-1.2	-1.3
Chronic bronchitis/emphysema (father)	0.7	0.9	1.7	-0.9	0.1	-1.2	-1.1	-1.3	-0.5
Nervous feelings	0.7	1.3	2.6	1.1	-0.3	-1.0	1.6	-0.0	-1.6
Fluid intelligence score	0.7	1.5	3.8	1.3	-1.9	0.4	1.7	0.3	0.1
Falls in the last year	0.7	0.9	2.3	1.5	0.7	0.9	1.3	0.4	-0.2
Number of live births	0.7	1.0	2.8	-1.7	1.4	-0.0	-0.2	0.9	0.3
Depression (self-reported)	0.7	0.8	3.0	-0.4	-0.6	-0.0	-0.4	-1.1	-1.7
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	4.1	-0.1	0.3	-2.0	-1.0	-0.1	-0.3
Pulse rate, automated reading	0.7	2.4	6.7	-0.9	-0.7	-0.4	-1.4	-2.6	-2.0
Chest pain or discomfort	0.7	1.0	1.9	1.3	-1.4	0.9	0.1	0.8	1.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.5	-0.0	-0.2	0.6	1.0	-1.0	-1.6
Knee pain experienced in last month	0.7	1.1	2.3	-0.1	0.7	1.5	-0.3	1.4	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.9	1.3	-0.6	0.8	0.7	-0.3	-1.4
Average weekly red wine intake	0.7	1.0	2.1	0.8	-1.0	0.2	0.9	-1.1	-1.4
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.7	0.2	0.4	0.1	-1.3	0.7	1.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.3	-0.1	-0.5	-0.5	0.3	-1.4	-1.5
Heart disease (siblings)	0.7	0.9	3.6	0.4	-0.3	0.9	1.9	-0.7	-0.3
Schizophrenia (2018)	0.6	1.3	4.2	2.1	-1.1	1.2	0.4	0.8	-0.1
Alzheimer’s Disease (in father)	0.6	0.7	3.7	-1.9	0.4	-0.0	-0.2	0.3	-0.0
Bipolar Disorder (2011)	0.6	0.5	1.7	1.3	0.0	0.0	1.1	0.3	0.3
Fasting Glucose	0.6	0.7	1.7	-0.3	0.2	-0.8	0.5	-1.3	-1.1
Blood Eosinophil Count	0.6	4.3	13.2	-2.0	-1.3	-3.6	-2.3	0.1	1.4
Blood White Count	0.6	4.7	16.2	0.5	-2.6	-4.0	-1.3	-1.3	-1.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.5	0.6	0.3	1.6	1.1	0.8	1.3
Medication: Atenolol	0.6	0.7	1.7	-0.8	-0.8	0.3	0.3	-1.0	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.6	1.1	-0.6	0.9	1.3	-0.0	-1.2
Had menopause	0.6	0.8	2.4	0.9	0.9	0.6	1.5	0.4	-0.3
Pulse rate	0.6	1.1	2.1	-0.1	-0.3	-1.4	-1.5	-1.3	-0.8
Length of working week for main job	0.6	0.6	1.4	-1.2	-0.9	-0.2	-0.7	-0.9	-0.5
Comparative body size at age 10	0.6	1.6	3.0	-1.4	-1.7	1.3	-1.4	0.9	0.6
Number of children fathered	0.6	0.7	1.1	-0.7	0.8	-0.7	0.9	-0.6	-1.1
Medication: Seretide 50 evohaler	0.6	0.7	2.0	1.1	0.1	-1.4	0.3	-0.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.1	-0.4	-1.0	1.5	0.8	0.6	0.2
Medication: Aspirin	0.6	0.7	3.1	-0.4	0.7	0.7	1.8	0.4	-0.3
Illnesses of father: None of the above (group 1)	0.6	0.8	1.8	-1.3	-0.4	1.2	-0.8	-0.0	0.8
Average weekly champagne plus white wine intake	0.6	0.9	2.4	0.9	0.1	-0.7	1.5	0.7	-1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.7	0.4	-0.4	1.9	-0.7	-0.1	0.3
Medication: Bendroflumethiazide	0.6	0.9	1.9	0.8	0.5	0.8	-0.3	1.4	1.4
Number of operations (self-reported)	0.6	0.9	3.6	-0.6	-0.0	0.1	-0.5	-1.0	-1.9
Average weekly beer plus cider intake	0.6	0.9	2.3	1.2	1.5	0.6	0.9	-0.5	0.4
Worry (Nagel 2018)	0.5	1.0	3.6	0.3	0.5	-0.6	0.9	-1.0	-1.9
Smoking Status	0.5	1.1	2.8	1.4	1.7	-0.9	0.6	-0.6	-0.4
Lung FEV1/FVC ratio	0.5	2.6	5.3	1.4	2.3	1.2	0.7	-1.4	-2.0
Number of treatments/medications taken	0.5	0.9	2.9	0.6	-0.1	0.1	-0.3	1.5	1.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.8	0.8	-0.1	-0.5	0.6	-1.0	-1.3
Angina	0.5	0.7	1.5	0.3	-0.3	1.0	1.1	-0.5	-1.2
Medication for hormone replacement therapy	0.5	0.6	2.3	-0.4	0.8	-1.5	-0.3	0.4	-0.4
Medication: Co-codamol	0.5	0.6	0.9	0.7	-0.8	-0.2	-1.0	0.8	0.9
Impedance of leg (right)	0.5	2.2	5.8	-0.1	0.5	-2.3	0.5	-2.4	-1.2
Hand grip strength (right)	0.5	1.3	3.5	-1.7	-0.5	-0.5	-1.9	-1.2	-0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	0.4	-1.1	1.1	0.7	-0.5	-0.5
Waist circumference	0.5	2.0	5.6	1.7	0.2	2.4	-0.1	1.5	0.9
Past tobacco smoking	0.5	0.9	2.4	-0.8	-1.5	1.5	-0.3	0.3	0.3
Hair/balding pattern: Pattern 2	0.5	0.6	1.6	-1.3	0.5	1.0	-0.4	-0.2	-0.7
Illnesses of siblings	0.5	0.7	2.2	0.2	0.5	-1.0	-1.5	-0.3	0.7
Neuroticism score	0.5	1.1	2.9	0.2	-0.7	-0.9	0.4	-1.5	-1.7
Illnesses of mother	0.5	0.6	1.3	1.1	0.3	1.0	1.1	-0.2	-0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	3.0	-0.1	-1.7	0.1	0.3	-0.9	-1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.8	0.3	-1.2	-1.3	0.3	-0.0	0.8
Forced vital capacity (FVC), Best measure	0.5	1.8	8.7	-0.1	-2.9	0.0	-1.2	-0.5	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.6	-1.2	0.6	-0.1	0.5	-1.1	-0.9
Angina (self-reported)	0.5	0.6	1.3	0.3	-0.2	1.0	1.1	-0.5	-1.0
Mood swings	0.5	0.8	2.1	0.2	-0.1	-1.0	0.3	-1.4	-1.4
Medication for cholesterol	0.5	0.8	3.0	-0.3	-0.9	0.1	-1.7	-1.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.3	-1.1	-0.5	-0.9	0.1	-0.9	-0.5
Mineral and other dietary supplements	0.5	0.7	3.3	-0.8	0.1	-1.8	-0.2	0.1	0.3
Medication: Aspirin	0.5	0.7	3.4	-0.3	0.5	0.6	1.8	0.2	-0.4
Irritability	0.5	0.9	1.9	1.4	-0.4	0.7	1.4	0.1	-1.0
Myopia	0.5	0.7	2.0	1.3	-0.2	0.4	0.2	0.6	1.4
Depression (Nagel 2018)	0.4	0.6	1.3	0.3	-0.8	0.7	1.1	0.4	-0.9
Major Depression (MDD)	0.4	0.5	1.0	0.8	1.0	0.2	1.0	0.4	0.5
Reaction Time	0.4	0.8	1.8	-1.2	-1.0	-0.1	-0.4	1.3	0.6
Prostate Cancer	0.4	0.6	2.4	-0.2	0.9	-1.6	-0.2	-0.3	-0.1
LDL Cholesterol	0.4	0.6	1.1	0.3	-1.0	-0.3	-0.6	-0.9	-1.0
Cardiovascular Disease	0.4	1.4	3.7	1.2	-0.3	1.7	1.9	-0.0	-0.5
Lung FVC	0.4	1.9	4.7	-0.6	-2.1	-0.9	-2.2	-1.0	-0.4
Chronotype (morning person)	0.4	0.9	1.8	-0.8	-0.4	1.0	-0.7	1.1	1.3
Average weekly spirits intake	0.4	0.4	0.8	0.1	0.9	0.8	0.7	0.8	0.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.5	0.8	0.6	0.1	1.2	-0.2	-0.6
Supplements: Glucosamine	0.4	0.5	1.2	0.9	-1.1	0.3	-0.0	-0.6	-0.8
High blood pressure (mother)	0.4	0.6	1.7	-0.2	-1.3	-0.3	-1.2	-0.2	-0.6
Impedance of leg (left)	0.4	1.9	5.6	-0.1	0.8	-2.0	0.0	-2.4	-1.1
Number of incorrect matches in round	0.4	0.6	1.6	-0.4	0.2	1.2	-0.7	-0.0	-1.1
Time employed in main current job	0.4	0.5	2.4	0.4	-0.0	1.6	0.5	0.3	-0.0
Exposure to tobacco smoke at home	0.4	0.5	2.0	-0.6	0.3	-1.4	0.6	-0.1	-0.4
Hair/balding pattern: Pattern 4	0.4	1.0	3.5	0.6	-1.9	-0.9	-0.3	0.4	1.0
High blood pressure (siblings)	0.4	0.6	2.6	-0.5	0.2	0.7	0.5	-0.5	-1.6
Worry too long after embarrassment	0.4	0.6	1.4	1.2	-0.0	0.2	0.9	-0.7	-1.0
Health satisfaction	0.4	0.6	2.5	-0.0	-0.3	0.3	-0.4	1.6	0.7
Heart disease (mother)	0.4	0.5	1.0	-0.5	-0.9	-1.0	-0.6	-0.4	-0.3
Miserableness	0.4	0.7	2.2	1.0	-0.1	-1.5	-0.3	-0.9	-0.3
Hearing aid user	0.4	0.4	1.6	-0.1	0.5	-0.3	-1.3	-0.2	0.7
Medication: Paracetamol	0.4	0.7	1.9	0.2	0.2	-1.1	-1.4	-0.9	0.2
Age started oral contraceptive pill	0.4	0.5	2.3	-0.6	0.1	1.5	0.1	-0.1	0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.0	0.7	-0.1	0.7	1.4	0.2	-0.3
Alcohol drinker status: Previous	0.4	0.5	1.2	-1.1	0.6	-0.2	-1.0	0.3	0.5
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.4	1.5	-1.5	-0.3	0.3	0.1	0.7
Neuroticism (2016)	0.3	0.4	0.8	-0.5	0.8	-0.0	0.6	-0.9	-0.5
Blood Red Count	0.3	3.2	6.9	2.6	-1.1	1.7	0.5	2.6	1.0
Vitamin and mineral supplements	0.3	0.4	1.7	0.4	-0.0	-1.3	-0.8	0.2	0.4
Diabetes (mother)	0.3	0.4	0.9	1.0	-0.8	0.2	0.6	0.3	0.2
Trunk fat percentage	0.3	1.4	3.0	1.3	1.6	1.7	0.6	-0.4	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.3	0.5	-0.3	0.6	1.1	0.9	0.2
Relative age voice broke	0.3	0.4	0.7	-0.7	-0.4	-0.5	-0.8	-0.5	-0.8
High blood pressure	0.3	0.7	1.6	1.3	1.1	0.8	0.8	0.5	0.4
Multivitamins +/- minerals	0.3	0.4	1.7	-0.5	-0.5	1.3	0.2	-0.2	0.1
Body mass index (BMI)	0.3	1.2	4.4	1.3	0.3	2.1	-0.1	0.8	0.3
Trunk fat mass	0.3	1.2	4.6	1.0	1.1	2.1	0.2	-0.0	-0.5
Forced vital capacity (FVC)	0.3	1.2	5.0	-0.0	-2.2	0.0	-1.2	-0.1	0.9
Heart attack	0.3	0.4	1.7	0.6	0.1	0.7	1.3	0.1	-0.4
Father’s age at death	0.3	0.5	1.1	0.9	0.6	0.4	-0.3	0.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.2	0.5	0.0	-1.1	-0.3	-0.5	-0.4
Prospective memory result	0.3	0.4	1.5	-1.2	0.6	0.4	0.0	0.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	4.1	0.2	-2.0	0.0	-0.8	-0.7	0.2
Impedance of arm (left)	0.3	1.4	3.1	0.4	1.8	-0.7	1.0	-1.5	-1.1
Birth weight of first child	0.3	0.5	1.5	0.9	1.2	0.6	0.5	0.4	-0.2
Peak expiratory flow (PEF)	0.3	0.7	1.4	0.5	1.1	1.2	0.7	0.4	0.9
Medication: Paracetamol	0.3	0.5	1.2	0.3	0.5	-1.1	-1.0	-0.6	0.4
Glaucoma (self-reported)	0.3	0.4	1.3	0.3	-1.2	0.1	0.3	-0.9	-0.3
Body fat percentage	0.3	1.1	3.1	1.3	1.4	1.8	0.3	-0.1	-0.3
Eye problems/disorders: None of the above	0.3	0.4	1.1	-0.8	0.4	-0.2	-1.1	-0.6	-0.1
Medication for pain relief, constipation, heartburn	0.3	0.5	1.9	0.1	0.3	1.4	-0.5	0.6	0.4
Neck or shoulder pain in last month	0.3	0.4	1.1	-0.1	-0.1	-0.4	-1.0	-1.1	-0.4
Medication: Blood pressure	0.3	0.5	2.1	-0.8	0.5	1.4	0.2	-0.4	0.1
Medication: Ibuprofen	0.3	0.4	0.7	0.5	-0.3	-0.6	-0.7	-0.9	-0.4
Whole body fat mass	0.3	1.1	4.5	1.1	0.8	2.1	-0.1	0.1	-0.0
Leg fat mass (right)	0.3	1.1	4.4	1.2	0.7	2.1	0.0	0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.8	-1.4	-0.9	0.2	-0.1	0.3	1.2
Arm fat percentage (left)	0.3	1.3	4.5	1.3	0.9	2.1	0.5	0.2	-0.3
Loneliness, isolation	0.3	0.5	1.8	0.2	0.4	0.3	0.5	0.7	1.3
Back pain experienced in last month	0.3	0.4	1.4	-0.7	-0.7	0.0	-1.2	-0.5	-0.1
Eye problems/disorders: Glaucoma	0.3	0.4	1.6	0.4	-1.3	0.1	0.4	-0.4	-0.2
Fractured/broken bones in last 5 years	0.3	0.4	0.8	0.4	0.9	0.6	0.5	0.8	0.3
Pain experienced in last month	0.3	0.5	1.1	0.6	0.8	0.4	1.1	0.5	0.5
Impedance of whole body	0.3	1.7	4.2	0.1	1.6	-1.2	0.6	-2.0	-1.3
Leg fat mass (left)	0.3	1.1	4.8	1.0	0.8	2.2	-0.1	0.5	0.2
Neuroticism (Nagel 2018)	0.2	0.5	2.0	0.2	0.0	0.5	0.8	-0.6	-1.4
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	1.1	0.9	-0.5	0.5	-0.3	0.5
Coronary Artery Disease (CAD)	0.2	0.3	1.2	0.6	1.1	0.1	-0.3	-0.2	0.1
HDL Cholesterol	0.2	0.3	0.7	-0.8	-0.8	-0.8	0.0	0.2	-0.2
Blood Platelet Count	0.2	2.8	6.2	1.0	-1.8	-1.2	0.0	-2.2	-2.5
Heel T-Score	0.2	1.3	3.0	-0.6	-0.3	1.4	-1.7	0.6	1.5
BMI	0.2	1.0	3.8	1.1	-0.3	2.0	-0.9	0.1	0.1
Systolic Blood Pressure	0.2	0.8	2.9	1.7	-1.3	-0.2	0.2	-0.1	0.2
Neuroticism	0.2	0.5	1.2	0.6	-0.6	-0.6	0.7	-0.6	-1.1
Relative age of first facial hair	0.2	0.3	0.9	-1.0	0.4	-0.3	-0.1	-0.9	0.1
Systolic blood pressure, automated reading	0.2	0.7	1.7	1.1	0.8	1.3	-0.1	0.4	0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	0.6	0.5	0.2	0.3	0.7	-0.1
Leg fat-free mass (left)	0.2	1.2	4.7	0.1	-0.4	2.2	0.1	1.3	0.8
Age when periods started (menarche)	0.2	0.5	1.1	-0.6	0.9	0.4	-0.2	-0.7	-1.1
Sitting height	0.2	1.2	2.4	-0.3	-1.5	0.8	1.2	1.3	1.0
Leg predicted mass (left)	0.2	1.2	4.5	0.1	-0.5	2.1	0.1	1.3	0.8
Hearing difficulty/problems with background noise	0.2	0.2	0.6	0.2	0.7	-0.0	-0.5	0.3	0.7
Had other major operations	0.2	0.2	0.7	0.3	0.5	0.2	-0.1	0.8	-0.4
Qualifications: None of the above	0.2	0.5	1.3	-0.5	1.2	-0.1	0.8	0.3	-0.8
Weight	0.2	0.9	4.7	0.6	-0.2	2.2	-0.0	0.5	0.2
Impedance of arm (right)	0.2	0.9	3.2	0.0	0.5	-0.7	0.6	-1.8	-1.1
Arm fat percentage (right)	0.2	0.8	3.4	1.0	0.2	1.9	0.2	-0.0	-0.4
Trunk fat-free mass	0.2	1.0	3.4	-1.1	-1.8	1.0	-0.5	0.4	0.3
Hip circumference	0.2	0.9	4.1	0.6	-0.7	2.0	-0.0	-0.0	-0.6
Alcohol intake versus 10 years previously	0.2	0.4	0.9	-0.5	0.3	0.1	-0.9	-1.0	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	0.2	0.0	-0.1	-0.9	-0.4	-0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.3	-0.8	-0.9	-0.4	-0.4	-0.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	-0.8	-0.5	0.2	0.4	-0.0	-0.3
Arm fat mass (right)	0.2	0.9	4.5	0.7	-0.0	2.1	0.2	0.2	-0.2
Trunk predicted mass	0.2	1.0	3.2	-1.0	-1.8	1.1	-0.4	0.4	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.4	0.3	-1.2	0.7	-0.2	-0.1	-0.3
Leg fat percentage (right)	0.2	0.7	2.0	1.4	0.8	1.3	0.1	-0.0	-0.1
Number of full brothers	0.2	0.3	0.8	0.6	0.9	0.0	-0.0	0.1	0.9
Qualifications: College or University degree	0.2	0.7	1.6	0.6	-0.1	0.2	1.0	-1.3	-1.2
Mean time to correctly identify matches	0.2	0.5	1.5	-1.2	-0.4	-0.5	0.3	0.9	0.1
Comparative height size at age 10	0.2	1.0	2.6	-1.1	-0.5	-0.5	-1.2	-0.3	1.6
Suffer from ‘nerves’	0.2	0.3	1.1	0.1	0.2	-0.8	1.0	0.3	-0.0
Overall health rating	0.2	0.5	1.3	0.4	0.4	-1.2	-0.8	0.1	0.9
Had major operations	0.2	0.3	1.1	-0.4	0.1	0.6	0.2	-0.3	-1.0
Leg fat-free mass (right)	0.2	1.2	4.7	0.1	-0.4	2.2	-0.2	1.4	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.9	-0.9	-0.3	0.6	0.1	-0.3	-0.0
Qualifications: nursing, teaching	0.2	0.4	2.0	1.4	-0.3	0.4	0.1	-0.1	0.0
Osteoporosis (self-reported)	0.2	0.2	1.1	0.0	1.1	-0.1	-0.5	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.7	-0.4	-0.4	-0.9	-1.3	0.1	-0.3
Whole body water mass	0.2	1.0	2.5	-0.6	-1.4	1.6	-0.2	0.9	0.6
Leg predicted mass (right)	0.2	1.3	5.1	0.1	-0.4	2.3	-0.1	1.3	0.8
Arm fat mass (left)	0.2	1.0	4.3	1.0	0.2	2.1	0.4	0.3	-0.3
Financial situation satisfaction	0.2	0.3	1.4	0.0	-1.2	0.0	-0.1	0.3	0.4
Medication: Blood pressure	0.2	0.3	0.6	0.3	0.6	-0.6	0.8	0.5	0.4
Illnesses of father: High blood pressure	0.2	0.3	1.0	1.0	-0.2	0.1	0.6	0.3	-0.3
Leg fat percentage (left)	0.2	0.9	2.4	1.3	1.1	1.5	-0.1	0.1	-0.0
Arm fat-free mass (left)	0.2	0.8	2.7	-0.5	-1.6	1.2	-0.3	0.4	0.1
Diastolic blood pressure, automated reading	0.2	0.5	1.2	1.1	0.6	1.1	-0.4	-0.4	0.0
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.3	-1.1	-1.1	-0.7	-0.6	-0.5	-0.4
Arm predicted mass (left)	0.2	0.8	3.2	-0.7	-1.8	1.0	-0.5	0.3	0.0
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	-0.0	-0.9	0.5	0.2	-0.1	-0.6
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.2	0.4	0.2	-0.6	-0.7	-0.5
Ovarian Cancer	0.1	0.1	0.1	0.1	-0.3	-0.3	0.1	-0.3	0.3
Crohns Disease (2012)	0.1	0.2	0.8	-0.3	0.1	-0.9	0.6	-0.3	0.2
Triglycerides	0.1	0.1	0.3	0.2	-0.5	-0.5	0.3	0.3	-0.0
Current tobacco smoking	0.1	0.1	0.3	0.6	0.4	0.1	-0.1	-0.5	-0.4
Fed-up feelings	0.1	0.1	0.2	0.3	0.4	0.2	-0.1	-0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.0	0.2	-1.0	0.3	-0.7	0.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	-0.6	-0.8	-0.2	-0.3	0.1	0.6
Financial difficulties in last 2 years	0.1	0.2	0.6	-0.7	0.3	-0.4	-0.1	0.2	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.2	0.4	-1.1	0.0	-1.1	-0.6	0.4
Medication: Lansoprazole	0.1	0.1	0.2	0.5	-0.4	-0.2	-0.4	-0.3	0.2
Standing height	0.1	0.8	1.8	-1.3	-1.2	0.3	0.5	-0.9	-0.7
Medication: Amlodipine	0.1	0.1	0.4	0.3	0.1	0.6	0.6	0.2	-0.1
Birth weight	0.1	0.3	0.7	-0.8	-0.8	-0.3	0.0	0.1	-0.5
Arm fat-free mass (right)	0.1	0.7	2.2	-0.5	-0.7	1.5	0.1	0.9	0.4
Pulse wave peak to peak time	0.1	0.1	0.5	0.7	0.4	0.0	-0.3	0.1	0.3
Arm predicted mass (right)	0.1	0.5	2.0	-0.5	-0.5	1.4	-0.3	0.6	0.3
Hypertension (Self-reported)	0.1	0.3	0.5	0.5	0.6	0.7	0.4	0.4	0.5
Whole body fat-free mass	0.1	0.8	2.2	-0.6	-1.2	1.5	-0.3	0.8	0.5
Smoking status: Current	0.1	0.2	0.7	0.8	0.4	0.6	0.5	-0.1	0.0
Basal metabolic rate	0.1	0.8	2.6	-0.3	-1.1	1.6	-0.3	0.6	0.5
Risk taking	0.1	0.2	0.5	0.5	-0.1	0.6	0.4	-0.7	0.2
Height	0.0	0.4	1.3	-1.1	-0.5	-0.6	0.3	0.3	-0.5
Hair Pigment	0.0	0.8	2.7	-0.7	0.5	-0.1	-0.3	-1.2	-1.6
Tanning	0.0	0.2	0.4	-0.3	-0.4	-0.5	0.4	0.5	-0.6
Number of self-reported non-cancer illnesses	0.0	0.1	0.3	0.0	-0.5	0.2	-0.2	-0.1	0.0

Hub : Genes

IL15RA

Models

Trait associations