Hub : Traits :

Medication: Levothyroxine sodium

313 significantly associated models · 90 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 1941929 1 1 2.3e-08 1.0e-07 1.4e-01 92 PUSL1
2 1 18972776 20503710 1 1 1.3e-08 7.7e-08 4.0e-05 42 CAPZB
3 1 107418424 109188382 1 2 2.9e-29 2.1e-29 1.0e+00 100 VAV3
4 1 113236087 115222434 9 9 1.4e-34 9.0e-84 NaN NaN AP4B1 AP4B1-AS1 DCLRE1B HIPK1 OLFML3 PHTF1 PTPN22
5 2 159836227 161259685 1 1 3.2e-07 4.9e-07 1.0e+00 100 AC009961.3
6 2 190818878 192525536 2 1 7.4e-08 8.4e-19 3.7e-15 21 NAB1
7 3 11350553 12928762 2 1 1.6e-08 1.0e-07 1.0e+00 100 TIMP4
8 3 168789705 170185994 1 1 1.0e-08 1.0e-06 6.9e-02 86 ARPM1
9 4 148303195 150060844 1 1 1.7e-15 1.6e-16 1.0e+00 100 NR3C2
10 5 101392473 103061825 1 1 6.0e-09 4.2e-09 1.1e-01 93 PAM
11 6 25296606 26689223 1 1 1.3e-08 6.0e-14 1.4e-08 43 U91328.19
12 6 34026489 35542476 2 1 8.4e-09 1.5e-08 1.2e-01 93 UHRF1BP1
13 6 89666956 91704536 2 2 6.2e-25 4.0e-25 1.0e+00 100 BACH2 MDN1
14 6 166651581 167841508 4 2 3.4e-20 3.6e-20 5.6e-01 100 AL133458.1
15 7 99591418 100979310 1 1 2.2e-07 2.9e-07 1.0e+00 100 GIGYF1
16 8 8092025 9669775 5 1 2.9e-10 7.2e-12 1.0e+00 100 SGK223
17 8 11094751 11891593 1 1 3.1e-08 3.4e-08 7.4e-02 90 OR7E161P
18 8 60736025 62220903 1 1 8.8e-08 9.3e-08 1.0e+00 100 RAB2A
19 9 99581811 101652673 5 3 1.4e-38 2.8e-51 1.3e-15 72 C9orf156 CORO2A TSTD2
20 10 4999536 6504126 2 2 5.5e-13 8.8e-14 8.1e-03 87 ASB13 FAM208B
21 10 63253359 64724096 1 1 3.6e-07 6.3e-14 3.8e-13 6 RTKN2
22 11 60549966 62346131 6 1 4.7e-09 1.7e-08 7.3e-01 100 FADS2
23 12 55601472 57125879 6 1 2.6e-10 3.5e-10 1.0e+00 100 RAB5B
24 12 110233500 113517494 19 8 3.3e-38 1.7e-63 NaN NaN ADAM1A ALDH2 HECTD4 RP3-462E2.3 TMEM116 VPS29
25 15 38088200 39556796 1 1 3.4e-10 1.7e-13 6.8e-05 71 RASGRP1
26 16 49650937 51097687 1 1 4.0e-07 1.1e-05 1.0e+00 100 BRD7
27 17 39570442 41265776 3 1 1.9e-11 1.4e-11 1.0e+00 100 RAB5C
28 17 44788310 46474610 4 1 2.1e-10 2.4e-10 1.6e-03 75 C17orf57
29 19 4118871 5529588 1 1 7.2e-10 3.2e-16 6.1e-08 56 TICAM1
30 19 49279612 50909389 2 2 3.1e-07 5.6e-07 1.0e+00 100 ALDH16A1 CPT1C
31 22 36867133 38292974 2 1 4.9e-15 1.9e-15 4.5e-05 74 C1QTNF6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.23 1 0 0.0 0.00 1.0e+00 C17orf57
Crohns Disease (2017) 3.65 8 2 6.1 -0.27 4.6e-01 AL133458.1 AP4B1-AS1 CPT1C DCLRE1B FADS2 GIGYF1 HIPK1 RASGRP1
Irritable Bowel Disease (IBD) 2.52 4 1 3.0 0.88 4.7e-02 AL133458.1 BRD7 CPT1C HECTD4
Reaction Time 2.56 4 2 6.1 -0.74 1.5e-01 ALDH2 HECTD4 RAB5B RP3-462E2.3
Verbal and Numeric Reasoning (VNR) 1.43 3 0 0.0 0.00 1.0e+00 FADS2 PAM RAB5B
Breast Cancer 1.80 3 1 3.0 0.91 8.8e-02 AP4B1 DCLRE1B PHTF1
Coronary Artery Disease (CAD) 3.08 3 0 0.0 -0.96 4.4e-02 HECTD4 UHRF1BP1 VPS29
Crohns Disease (2012) 2.92 5 1 3.0 -0.05 9.2e-01 AL133458.1 DCLRE1B FADS2 HIPK1 RASGRP1
Fasting Glucose 1.60 1 0 0.0 0.00 1.0e+00 FADS2
HbA1C 1.54 1 0 0.0 0.00 1.0e+00 ADAM1A
HDL Cholesterol 2.16 3 2 6.1 0.00 1.0e+00 C17orf57 FADS2 UHRF1BP1
LDL Cholesterol 3.10 4 2 6.1 0.34 5.7e-01 ALDH2 C17orf57 FADS2 HECTD4
Lupus 4.60 6 1 3.0 -0.68 6.4e-02 DCLRE1B HECTD4 NAB1 OR7E161P RTKN2 SGK223
Neuroticism 2.07 3 2 6.1 0.00 1.0e+00 OR7E161P RAB2A SGK223
Primary Biliary Cirrhosis 2.55 2 0 0.0 0.00 1.0e+00 HECTD4 NAB1
Rheumatoid Arthritis 14.55 12 8 24.2 -0.95 1.9e-07 AP4B1 AP4B1-AS1 DCLRE1B FAM208B HECTD4 HIPK1 NAB1 OLFML3 PAM PHTF1 PTPN22 RASGRP1
Schizophrenia 1.30 2 0 0.0 0.00 1.0e+00 GIGYF1 SGK223
Triglycerides 2.18 2 2 6.1 0.00 1.0e+00 FADS2 OR7E161P
Ulcerative Colitis 1.68 1 0 0.0 0.00 1.0e+00 BRD7
Blood Eosinophil Count 13.39 19 14 42.4 -0.72 2.5e-04 ADAM1A ALDH2 AP4B1 ARPM1 ASB13 BACH2 C17orf57 FADS2 FAM208B GIGYF1 HECTD4 MDN1 NAB1 RAB5B RASGRP1 RP3-462E2.3 TIMP4 TMEM116 VPS29
Blood Platelet Count 7.30 13 8 24.2 -0.55 3.3e-02 ADAM1A C17orf57 C1QTNF6 CAPZB CORO2A FADS2 HECTD4 NAB1 PAM RP3-462E2.3 TIMP4 UHRF1BP1 VPS29
Blood Red Count 3.22 14 10 30.3 -0.45 9.1e-02 ADAM1A ALDH2 BACH2 CPT1C FADS2 GIGYF1 HECTD4 MDN1 NAB1 PAM RAB5B RP3-462E2.3 TMEM116 VPS29
Blood White Count 6.77 18 16 48.5 -0.57 7.3e-03 AC009961.3 ADAM1A AL133458.1 ALDH2 AP4B1 BACH2 DCLRE1B FADS2 HECTD4 OLFML3 PAM PHTF1 RAB2A RAB5C RP3-462E2.3 TIMP4 TMEM116 VPS29
Heel T-Score 0.89 6 4 12.1 0.11 8.3e-01 BACH2 CAPZB FADS2 NAB1 PUSL1 RAB5B
BMI 1.41 4 2 6.1 0.56 3.3e-01 HECTD4 RAB5B UHRF1BP1 VPS29
Height 0.80 16 11 33.3 0.26 3.1e-01 ADAM1A ALDH16A1 ALDH2 C17orf57 C9orf156 CAPZB CPT1C FADS2 HECTD4 NAB1 NR3C2 PAM PUSL1 RAB5C RP3-462E2.3 UHRF1BP1
Waist Hip Ratio (WHR) 1.52 6 4 12.1 -0.67 1.0e-01 ADAM1A BACH2 HECTD4 PAM TIMP4 UHRF1BP1
Systolic Blood Pressure 3.00 9 9 27.3 -0.79 6.3e-03 ADAM1A ALDH2 C17orf57 HECTD4 NAB1 PUSL1 RP3-462E2.3 TMEM116 VPS29
Smoking Status 1.49 3 1 3.0 0.00 1.0e+00 ADAM1A DCLRE1B RAB5B
Allergy or Eczema 2.83 5 4 12.1 0.51 3.0e-01 ADAM1A BACH2 HECTD4 MDN1 RAB5B
Cardiovascular Disease 2.74 8 4 12.1 -0.69 3.8e-02 ADAM1A ALDH2 C17orf57 HECTD4 RAB5B TMEM116 UHRF1BP1 VPS29
Hypothyroidism (self reported) 39.84 45 42 127.3 -0.99 9.5e-44 AC009961.3 ADAM1A AL133458.1 ALDH16A1 ALDH2 AP4B1 AP4B1-AS1 ARPM1 ASB13 BACH2 BRD7 C17orf57 C1QTNF6 C9orf156 CAPZB CORO2A CPT1C DCLRE1B FADS2 FAM208B GIGYF1 HECTD4 HIPK1 MDN1 NAB1 NR3C2 OLFML3 PAM PHTF1 PTPN22 PUSL1 RAB2A RAB5B RAB5C RASGRP1 RP3-462E2.3 RTKN2 SGK223 TICAM1 TIMP4 TMEM116 TSTD2 UHRF1BP1 VAV3 VPS29
Respiratory disease 2.81 4 3 9.1 0.98 1.7e-02 BACH2 FADS2 FAM208B RAB5B
Type 2 Diabetes (T2D) 1.64 2 0 0.0 0.00 1.0e+00 ADAM1A PAM
Lung FEV1/FVC ratio 0.99 3 2 6.1 0.00 1.0e+00 AC009961.3 BACH2 RAB5B
Lung FVC 1.19 6 1 3.0 -0.35 4.5e-01 AP4B1 HECTD4 PAM RAB5B RAB5C RP3-462E2.3
Neuroticism 1.07 1 0 0.0 0.00 1.0e+00 TIMP4
Chronotype (morning person) 1.38 4 0 0.0 -0.79 1.2e-01 ALDH2 HECTD4 TIMP4 TMEM116
Hair Pigment 0.38 9 8 24.2 0.06 8.6e-01 ALDH2 C17orf57 C9orf156 CORO2A FADS2 GIGYF1 HECTD4 RP3-462E2.3 TSTD2
Tanning 0.28 3 0 0.0 -0.98 2.2e-02 ALDH2 HECTD4 RP3-462E2.3
Number of treatments/medications taken 3.61 7 1 3.0 0.97 9.8e-06 ADAM1A AL133458.1 DCLRE1B FADS2 FAM208B HECTD4 PTPN22
Sensitivity / hurt feelings 1.36 2 1 3.0 0.00 1.0e+00 OR7E161P SGK223
Frequency of depressed mood in last 2 weeks 1.59 2 0 0.0 0.00 1.0e+00 OR7E161P RAB5C
Systolic blood pressure, automated reading 2.39 7 5 15.2 0.35 3.9e-01 ALDH2 HECTD4 NAB1 OR7E161P PUSL1 SGK223 TMEM116
Angina 1.88 1 0 0.0 0.00 1.0e+00 C17orf57
Vitamin and mineral supplements 1.15 1 0 0.0 0.00 1.0e+00 U91328.19
Impedance of leg (right) 1.64 5 4 12.1 0.60 2.9e-01 OR7E161P PAM RAB5B SGK223 UHRF1BP1
Leg fat-free mass (left) 2.05 8 7 21.2 -0.34 3.6e-01 C17orf57 HECTD4 OR7E161P RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Trunk fat percentage 1.34 2 2 6.1 0.00 1.0e+00 U91328.19 UHRF1BP1
Fed-up feelings 2.33 4 2 6.1 -0.85 6.8e-02 ALDH2 HECTD4 OR7E161P SGK223
Relative age voice broke 1.14 1 0 0.0 0.00 1.0e+00 ADAM1A
Taking other prescription medications 5.72 8 4 12.1 0.98 1.3e-06 ADAM1A AL133458.1 DCLRE1B FAM208B HECTD4 HIPK1 RAB5C RP3-462E2.3
Age when periods started (menarche) 1.22 1 0 0.0 0.00 1.0e+00 DCLRE1B
Heel bone mineral density (BMD) T-score, automated (left) 2.66 4 2 6.1 -0.58 4.2e-01 FADS2 OR7E161P SGK223 U91328.19
High blood pressure 2.89 9 4 12.1 0.23 5.2e-01 ADAM1A ALDH2 C17orf57 HECTD4 OR7E161P RAB5B RTKN2 SGK223 TMEM116
Hayfever, allergic rhinitis or eczema 2.79 5 3 9.1 -0.57 3.1e-01 ADAM1A BACH2 HECTD4 RAB5B U91328.19
Medication: Atenolol 2.93 1 1 3.0 0.00 1.0e+00 HECTD4
Sitting height 0.79 6 3 9.1 0.49 3.3e-01 C17orf57 CAPZB FADS2 OR7E161P U91328.19 UHRF1BP1
Body mass index (BMI) 2.22 7 5 15.2 -0.41 3.6e-01 HECTD4 OR7E161P RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Impedance of leg (left) 1.64 5 4 12.1 0.58 3.0e-01 OR7E161P PAM RAB5B SGK223 UHRF1BP1
Leg predicted mass (left) 2.04 8 7 21.2 -0.34 3.7e-01 C17orf57 HECTD4 OR7E161P RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Trunk fat mass 1.77 3 2 6.1 0.00 1.0e+00 OR7E161P U91328.19 UHRF1BP1
Waist circumference 1.53 5 2 6.1 -0.46 4.4e-01 HECTD4 RAB5B TIMP4 U91328.19 UHRF1BP1
Past tobacco smoking 2.03 5 0 0.0 -0.07 9.0e-01 ADAM1A ALDH2 DCLRE1B HECTD4 RAB5B
Nervous feelings 1.93 3 3 9.1 0.00 1.0e+00 OR7E161P SGK223 U91328.19
Frequency of tenseness / restlessness in last 2 weeks 1.38 1 0 0.0 0.00 1.0e+00 HECTD4
Hearing difficulty/problems with background noise 1.39 1 0 0.0 0.00 1.0e+00 U91328.19
Forced vital capacity (FVC) 0.81 1 0 0.0 0.00 1.0e+00 RAB5B
Heel bone mineral density (BMD) T-score, automated (right) 2.74 5 2 6.1 -0.44 4.6e-01 CAPZB FADS2 OR7E161P SGK223 U91328.19
Ever unenthusiastic/disinterested for a whole week 1.62 1 0 0.0 0.00 1.0e+00 TIMP4
Qualifications: None of the above 1.24 1 1 3.0 0.00 1.0e+00 RAB5B
Mouth/teeth dental problems 1.17 1 0 0.0 0.00 1.0e+00 SGK223
Allergy 2.52 5 3 9.1 0.43 4.7e-01 ADAM1A BACH2 FADS2 RAB5B U91328.19
Diabetes (self-reported) 1.79 1 0 0.0 0.00 1.0e+00 DCLRE1B
Hayfever/allergic rhinitis (self-reported) 2.17 2 0 0.0 0.00 1.0e+00 RAB5B U91328.19
Medication: Ramipril 1.69 1 0 0.0 0.00 1.0e+00 ADAM1A
Medication: Simvastatin 1.38 2 0 0.0 0.00 1.0e+00 C17orf57 FADS2
Fluid intelligence score 1.19 2 0 0.0 0.00 1.0e+00 FADS2 RAB5B
Illnesses of siblings 1.68 2 0 0.0 0.00 1.0e+00 ADAM1A HECTD4
Neuroticism score 2.49 4 2 6.1 0.38 6.2e-01 OR7E161P SGK223 TIMP4 U91328.19
Weight 2.31 9 6 18.2 -0.34 3.3e-01 C17orf57 HECTD4 OR7E161P RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Impedance of arm (right) 1.90 9 6 18.2 0.58 9.9e-02 ADAM1A HECTD4 NR3C2 OR7E161P RAB5B RTKN2 SGK223 UHRF1BP1 VPS29
Arm fat percentage (right) 1.42 5 3 9.1 -0.17 7.9e-01 OR7E161P RAB5B SGK223 U91328.19 UHRF1BP1
Trunk fat-free mass 1.85 11 5 15.2 -0.53 7.5e-02 ADAM1A ALDH2 C17orf57 HECTD4 OR7E161P PUSL1 RAB5B RP3-462E2.3 U91328.19 UHRF1BP1 VPS29
Hip circumference 2.67 10 5 15.2 -0.36 2.7e-01 ALDH2 C17orf57 HECTD4 OR7E161P RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Father's age at death 2.04 2 0 0.0 0.00 1.0e+00 HECTD4 RP3-462E2.3
Worrier / anxious feelings 2.24 3 2 6.1 0.00 1.0e+00 OR7E161P PAM SGK223
Number of live births 1.48 1 0 0.0 0.00 1.0e+00 FADS2
Forced expiratory volume in 1-second (FEV1) 1.08 4 1 3.0 -0.47 5.3e-01 OR7E161P RAB5B SGK223 U91328.19
Pulse rate 2.32 2 2 6.1 0.00 1.0e+00 FADS2 GIGYF1
Qualifications: A levels/AS levels or equivalent 1.03 1 0 0.0 0.00 1.0e+00 RAB5B
Mouth/teeth dental problems: Dentures 1.84 2 1 3.0 0.00 1.0e+00 SGK223 U91328.19
Asthma 2.50 3 3 9.1 0.00 1.0e+00 BACH2 FADS2 RAB5B
Medication: Ibuprofen (e.g. Nurofen) 1.70 1 0 0.0 0.00 1.0e+00 HECTD4
Medication: Cholesterol lowering 1.45 1 0 0.0 0.00 1.0e+00 C17orf57
Forced expiratory volume in 1-second (FEV1), Best measure 1.00 2 1 3.0 0.00 1.0e+00 RAB5B SGK223
Pulse wave Arterial Stiffness index 2.23 1 1 3.0 0.00 1.0e+00 ADAM1A
Impedance of arm (left) 1.88 9 5 15.2 0.65 4.3e-02 ADAM1A HECTD4 NR3C2 OR7E161P RAB5B RP3-462E2.3 SGK223 UHRF1BP1 VPS29
Arm fat mass (right) 2.02 6 5 15.2 -0.39 4.4e-01 HECTD4 OR7E161P RAB5B SGK223 U91328.19 UHRF1BP1
Trunk predicted mass 1.86 12 6 18.2 -0.55 5.4e-02 ADAM1A ALDH2 ARPM1 C17orf57 HECTD4 OR7E161P PUSL1 RAB5B RP3-462E2.3 U91328.19 UHRF1BP1 VPS29
Standing height 0.94 11 7 21.2 0.09 7.7e-01 C17orf57 C9orf156 CAPZB FADS2 HECTD4 NAB1 OR7E161P RAB5C SGK223 U91328.19 UHRF1BP1
Breastfed as a baby 1.66 1 1 3.0 0.00 1.0e+00 PUSL1
Tense / 'highly strung' 1.84 3 1 3.0 0.00 1.0e+00 OR7E161P SGK223 TIMP4
Hair/balding pattern: Pattern 4 0.92 1 0 0.0 0.00 1.0e+00 FADS2
Birth weight of first child 3.26 6 1 3.0 -0.72 6.6e-02 ADAM1A ALDH2 HECTD4 RAB2A RAB5B RP3-462E2.3
Peak expiratory flow (PEF) 1.26 3 2 6.1 0.00 1.0e+00 OR7E161P PUSL1 SGK223
Medication: Paracetamol 1.54 1 0 0.0 0.00 1.0e+00 RAB5B
Headache pain in last month 2.00 3 1 3.0 -0.93 6.8e-02 HECTD4 RAB5B U91328.19
Medication for cholesterol, blood pressure or diabetes 1.94 2 0 0.0 0.00 1.0e+00 ADAM1A C17orf57
Gout (self-reported) 1.41 1 0 0.0 0.00 1.0e+00 HECTD4
Hypothyroidism/myxoedema (self-reported) 34.49 47 44 133.3 1.00 1.7e-53 AC009961.3 ADAM1A AL133458.1 ALDH16A1 ALDH2 AP4B1 AP4B1-AS1 ARPM1 ASB13 BACH2 BRD7 C17orf57 C1QTNF6 C9orf156 CAPZB CORO2A CPT1C DCLRE1B FADS2 FAM208B GIGYF1 HECTD4 HIPK1 MDN1 NAB1 NR3C2 OLFML3 OR7E161P PAM PHTF1 PTPN22 PUSL1 RAB2A RAB5B RAB5C RASGRP1 RP3-462E2.3 RTKN2 SGK223 TICAM1 TIMP4 TMEM116 TSTD2 U91328.19 UHRF1BP1 VAV3 VPS29
Medication: Ventolin 100micrograms inhaler 1.49 2 0 0.0 0.00 1.0e+00 BACH2 RAB5B
Birth weight 2.69 4 2 6.1 -0.97 5.4e-03 ADAM1A ALDH2 HECTD4 VPS29
High blood pressure (siblings) 1.89 1 0 0.0 0.00 1.0e+00 HECTD4
Forced vital capacity (FVC), Best measure 0.72 1 0 0.0 0.00 1.0e+00 RAB5B
Body fat percentage 1.45 2 2 6.1 0.00 1.0e+00 U91328.19 UHRF1BP1
Leg fat percentage (right) 1.68 4 2 6.1 -0.36 6.4e-01 OR7E161P SGK223 U91328.19 UHRF1BP1
Arm fat-free mass (right) 2.16 9 6 18.2 -0.65 4.0e-02 ADAM1A HECTD4 OR7E161P RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Comparative body size at age 10 1.43 4 2 6.1 -0.33 6.7e-01 OR7E161P SGK223 U91328.19 UHRF1BP1
Worry too long after embarrassment 2.20 2 1 3.0 0.00 1.0e+00 OR7E161P SGK223
Seen a psychiatrist for nerves, anxiety, tension or depression 1.73 2 1 3.0 0.00 1.0e+00 TIMP4 U91328.19
Wheeze or whistling in the chest in last year 1.30 1 0 0.0 0.00 1.0e+00 FADS2
Age at first live birth 1.31 1 0 0.0 0.00 1.0e+00 RAB5B
Pulse wave peak to peak time 2.17 1 1 3.0 0.00 1.0e+00 ADAM1A
Qualifications: College or University degree 1.10 3 1 3.0 0.00 1.0e+00 PAM RAB5B U91328.19
Emphysema/chronic bronchitis 1.83 1 0 0.0 0.00 1.0e+00 SGK223
Medication for pain relief, constipation, heartburn 1.83 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Medication: Blood pressure 2.20 4 1 3.0 0.72 1.7e-01 ADAM1A ALDH2 HECTD4 OR7E161P
Angina (self-reported) 1.86 1 0 0.0 0.00 1.0e+00 C17orf57
Medication: Omeprazole 1.47 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Mean time to correctly identify matches 2.46 3 2 6.1 0.99 1.4e-02 ALDH2 HECTD4 RP3-462E2.3
Whole body fat mass 1.91 7 2 6.1 -0.33 4.7e-01 HECTD4 OR7E161P RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Leg fat mass (right) 2.22 7 4 12.1 -0.44 2.7e-01 HECTD4 OR7E161P RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Arm predicted mass (right) 2.21 9 8 24.2 -0.65 4.3e-02 ADAM1A HECTD4 OR7E161P RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Pulse rate, automated reading 2.96 6 2 6.1 -0.49 3.2e-01 FADS2 GIGYF1 NAB1 RAB5B UHRF1BP1 VPS29
Alcohol intake frequency. 1.09 1 0 0.0 0.00 1.0e+00 RAB5B
Comparative height size at age 10 1.08 5 2 6.1 -0.98 5.6e-04 ALDH2 C9orf156 CAPZB HECTD4 NR3C2
Suffer from 'nerves' 1.76 2 0 0.0 0.00 1.0e+00 OR7E161P SGK223
Overall health rating 1.72 4 0 0.0 0.32 6.8e-01 DCLRE1B OR7E161P SGK223 UHRF1BP1
Chest pain or discomfort 1.33 1 0 0.0 0.00 1.0e+00 C17orf57
Qualifications: NVQ or HND or HNC or equivalent 1.39 2 0 0.0 0.00 1.0e+00 ALDH2 HECTD4
Supplements: Vitamin C 1.42 1 0 0.0 0.00 1.0e+00 U91328.19
Hypertension (Self-reported) 2.72 8 4 12.1 0.07 8.6e-01 ADAM1A ALDH2 C17orf57 HECTD4 OR7E161P RAB5B RTKN2 SGK223
Illnesses of father: Heart disease 2.08 1 0 0.0 0.00 1.0e+00 HECTD4
Smoking status: Previous 2.08 4 0 0.0 0.59 3.0e-01 ADAM1A ALDH2 HECTD4 RAB5B
Whole body fat-free mass 1.98 11 5 15.2 -0.48 1.1e-01 ADAM1A C17orf57 HECTD4 OR7E161P PUSL1 RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Leg fat-free mass (right) 2.00 8 7 21.2 -0.35 3.5e-01 C17orf57 HECTD4 OR7E161P RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Arm fat percentage (left) 1.46 4 4 12.1 -0.32 6.8e-01 OR7E161P SGK223 U91328.19 UHRF1BP1
Mood swings 1.67 2 1 3.0 0.00 1.0e+00 OR7E161P SGK223
Loneliness, isolation 1.89 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Long-standing illness, disability or infirmity 3.75 5 1 3.0 0.97 1.1e-03 AL133458.1 DCLRE1B FAM208B HECTD4 RASGRP1
Diabetes diagnosed by doctor 2.03 1 0 0.0 0.00 1.0e+00 DCLRE1B
Friendships satisfaction 1.14 1 0 0.0 0.00 1.0e+00 VPS29
Mouth/teeth dental problems: Mouth ulcers 2.13 2 0 0.0 0.00 1.0e+00 BRD7 PAM
Medication for cholesterol 2.15 1 0 0.0 0.00 1.0e+00 HECTD4
Mineral and other dietary supplements 1.54 1 0 0.0 0.00 1.0e+00 SGK223
Asthma (self-reported) 2.65 3 3 9.1 0.00 1.0e+00 BACH2 FADS2 RAB5B
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.41 3 1 3.0 0.00 1.0e+00 OR7E161P RAB5B U91328.19
Whole body water mass 2.00 11 5 15.2 -0.49 1.1e-01 ADAM1A C17orf57 HECTD4 OR7E161P PUSL1 RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Leg predicted mass (right) 2.00 8 7 21.2 -0.35 3.5e-01 C17orf57 HECTD4 OR7E161P RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Arm fat mass (left) 2.01 6 5 15.2 -0.37 4.7e-01 HECTD4 OR7E161P RAB5B SGK223 U91328.19 UHRF1BP1
Number of self-reported non-cancer illnesses 3.28 5 1 3.0 0.99 3.2e-04 AL133458.1 ALDH2 FAM208B HECTD4 RASGRP1
Average weekly champagne plus white wine intake 1.29 1 1 3.0 0.00 1.0e+00 FADS2
Miserableness 1.77 2 2 6.1 0.00 1.0e+00 OR7E161P SGK223
Guilty feelings 1.69 2 1 3.0 0.00 1.0e+00 OR7E161P SGK223
Medication: Blood pressure 2.81 5 3 9.1 0.17 7.5e-01 ALDH2 ARPM1 HECTD4 OR7E161P SGK223
Supplements: Fish oil (including cod liver oil) 1.67 2 0 0.0 0.00 1.0e+00 OR7E161P SGK223
High cholesterol (Self-reported) 1.62 2 1 3.0 0.00 1.0e+00 C17orf57 FADS2
Medication: Bendroflumethiazide 2.06 2 1 3.0 0.00 1.0e+00 OR7E161P SGK223
Medication: Lisinopril 1.71 1 0 0.0 0.00 1.0e+00 HECTD4
Ever smoked 1.72 2 0 0.0 0.00 1.0e+00 DCLRE1B HECTD4
Basal metabolic rate 2.16 11 6 18.2 -0.46 1.3e-01 ADAM1A C17orf57 HECTD4 OR7E161P PUSL1 RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Leg fat percentage (left) 1.72 4 2 6.1 -0.36 6.4e-01 OR7E161P SGK223 U91328.19 UHRF1BP1
Arm fat-free mass (left) 2.26 11 7 21.2 -0.55 6.6e-02 ADAM1A ALDH2 C17orf57 HECTD4 OR7E161P RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29
Number of operations (self-reported) 1.50 1 0 0.0 0.00 1.0e+00 ARPM1
Average weekly beer plus cider intake 1.42 2 0 0.0 0.00 1.0e+00 OR7E161P SGK223
Irritability 2.10 3 2 6.1 0.00 1.0e+00 FADS2 OR7E161P SGK223
Ever had prostate specific antigen (PSA) test 1.03 1 0 0.0 0.00 1.0e+00 C17orf57
Age started oral contraceptive pill 1.32 2 0 0.0 0.00 1.0e+00 AL133458.1 RAB5B
Diastolic blood pressure, automated reading 4.17 10 8 24.2 0.53 7.4e-02 ADAM1A ALDH2 GIGYF1 HECTD4 OR7E161P RAB5B RP3-462E2.3 SGK223 TMEM116 VPS29
Ever depressed for a whole week 1.42 1 0 0.0 0.00 1.0e+00 TIMP4
Myopia 1.47 1 0 0.0 0.00 1.0e+00 FADS2
Vascular/heart problems diagnosed by doctor 2.82 9 5 15.2 -0.44 2.0e-01 ADAM1A ALDH2 C17orf57 HECTD4 OR7E161P RTKN2 SGK223 TMEM116 VPS29
Pain experienced in last month 1.34 2 0 0.0 0.00 1.0e+00 HECTD4 RAB5B
Impedance of whole body 1.83 9 5 15.2 0.69 3.8e-02 ADAM1A ARPM1 HECTD4 OR7E161P RAB5B RTKN2 SGK223 UHRF1BP1 VPS29
Leg fat mass (left) 2.26 7 5 15.2 -0.45 2.6e-01 HECTD4 OR7E161P RAB5B SGK223 U91328.19 UHRF1BP1 VPS29
Arm predicted mass (left) 2.30 11 7 21.2 -0.53 7.5e-02 ADAM1A ALDH2 C17orf57 HECTD4 OR7E161P RAB5B RP3-462E2.3 SGK223 U91328.19 UHRF1BP1 VPS29

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 6 0.172 1.71
GTEx Adipose Visceral Omentum 4 0.196 1.64
GTEx Adrenal Gland 4 0.275 1.77
GTEx Artery Aorta 3 0.101 1.70
GTEx Artery Coronary 4 0.338 1.74
GTEx Artery Tibial 11 0.292 1.78
GTEx Brain Caudate basal ganglia 1 0.109 1.67
GTEx Brain Cerebellar Hemisphere 7 0.470 1.87
GTEx Brain Cerebellum 7 0.353 1.87
GTEx Brain Cortex 3 0.290 1.74
GTEx Brain Frontal Cortex BA9 5 0.541 1.88
GTEx Brain Hippocampus 1 0.191 1.65
GTEx Brain Hypothalamus 1 0.169 1.53
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.64
GTEx Brain Putamen basal ganglia 2 0.321 1.92
GTEx Breast Mammary Tissue 5 0.253 1.70
GTEx Breast Mammary Tissue (Male) 4 0.335 1.63
GTEx Breast Mammary Tissue (Female) 4 0.243 1.70
GTEx Cells EBV-transformed lymphocytes 3 0.211 1.74
GTEx Cells Transformed fibroblasts 11 0.262 1.66
GTEx Colon Sigmoid 4 0.274 1.74
GTEx Colon Transverse 10 0.484 1.74
GTEx Esophagus Gastroesophageal Junction 9 0.623 1.76
GTEx Esophagus Mucosa 7 0.211 1.67
GTEx Esophagus Muscularis 7 0.217 1.68
GTEx Heart Atrial Appendage 4 0.253 1.73
GTEx Heart Left Ventricle 5 0.327 1.60
GTEx Liver 1 0.139 1.70
GTEx Lung 9 0.313 1.75
GTEx Muscle Skeletal 9 0.311 1.68
GTEx Nerve Tibial 12 0.278 1.77
GTEx Ovary 4 0.441 1.82
GTEx Pancreas 2 0.123 1.64
GTEx Pituitary 2 0.179 1.73
GTEx Prostate 2 0.240 1.75
GTEx Skin Not Sun Exposed Suprapubic 8 0.325 1.82
GTEx Skin Sun Exposed Lower leg 10 0.275 1.75
GTEx Small Intestine Terminal Ileum 0 0.000 1.79
GTEx Spleen 2 0.142 1.73
GTEx Stomach 7 0.481 1.76
GTEx Testis 12 0.380 1.76
GTEx Thyroid 13 0.325 1.80
GTEx Uterus 2 0.353 1.90
GTEx Vagina 0 0.000 1.81
GTEx Whole Blood 7 0.351 1.93
METSIM Adipose 12 0.260 1.64
NTR Blood 7 0.291 1.88
ROSMAP Brain Pre-frontal Cortex 8 0.182 1.61
YFS Blood 12 0.260 1.78
CommonMind Brain Pre-frontal Cortex 14 0.260 1.63
TCGA Breast Tumor 3 0.391 1.66
TCGA Breast Normal 9 0.214 1.62
TCGA Ovarian Tumor 8 0.274 1.56
TCGA Prostate Tumor 5 0.145 1.64