Hub : Traits :

Number of self-reported non-cancer illnesses

52 significantly associated models · 20 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 71163715 73435171 1 1 1.1e-07 1.3e-09 5.0e-04 67 NEGR1
2 1 220314945 221696457 1 1 1.9e-07 1.3e-06 6.4e-01 99 RP11-295M18.6
3 2 102118712 103555146 1 1 2.6e-07 1.4e-07 1.2e-03 62 IL1RL2
4 4 103020804 104627833 4 1 1.4e-08 1.7e-08 3.2e-01 97 CISD2
5 5 131008194 132425049 1 1 4.8e-08 1.9e-08 7.6e-04 64 SLC22A5
6 7 1580921 2977732 1 1 1.5e-09 2.6e-13 2.4e-06 58 FTSJ2
7 7 73425238 74494207 2 1 3.4e-09 1.0e-06 4.8e-01 98 STAG3L2
8 12 111154626 113517494 3 1 4.6e-10 6.8e-12 2.3e-04 71 SH2B3
9 15 66797492 68789191 3 1 1.4e-08 7.1e-11 2.3e-04 68 AAGAB
10 17 37386899 38783469 1 1 1.1e-07 1.6e-06 3.8e-01 97 ORMDL3
11 17 46888301 48347817 1 1 2.5e-07 2.0e-10 9.9e-07 41 RP5-1029K10.2
12 20 61576647 62912463 1 1 3.0e-07 1.2e-06 1.3e-06 1 STMN3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 5.02 3 1 3.0 0.00 1.0e+00 ORMDL3 STAG3L2 STMN3
Irritable Bowel Disease (IBD) 6.60 4 2 6.1 0.13 8.7e-01 ORMDL3 SH2B3 STAG3L2 STMN3
Ulcerative Colitis (UC) 4.88 4 1 3.0 -0.30 7.0e-01 CISD2 ORMDL3 STAG3L2 STMN3
Major Depression (MDD) 3.79 1 1 3.0 0.00 1.0e+00 NEGR1
Reaction Time 3.19 1 1 3.0 0.00 1.0e+00 SH2B3
Verbal and Numeric Reasoning (VNR) 3.34 1 1 3.0 0.00 1.0e+00 NEGR1
Breast Cancer 1.61 1 0 0.0 0.00 1.0e+00 STAG3L2
Body Mass Index (BMI) (2010) 5.23 1 1 3.0 0.00 1.0e+00 NEGR1
Coronary Artery Disease (CAD) 2.57 1 0 0.0 0.00 1.0e+00 SH2B3
Crohns Disease (2012) 3.93 1 1 3.0 0.00 1.0e+00 STMN3
Mean Putamen Volume 1.83 1 0 0.0 0.00 1.0e+00 RP11-295M18.6
HDL Cholesterol 2.91 1 1 3.0 0.00 1.0e+00 ORMDL3
LDL Cholesterol 1.92 1 0 0.0 0.00 1.0e+00 SH2B3
Lupus 2.92 2 1 3.0 0.00 1.0e+00 ORMDL3 SH2B3
Neuroticism 1.65 1 0 0.0 0.00 1.0e+00 FTSJ2
Primary Biliary Cirrhosis 5.74 3 2 6.1 0.00 1.0e+00 CISD2 ORMDL3 SH2B3
Rheumatoid Arthritis 3.22 1 0 0.0 0.00 1.0e+00 SH2B3
Schizophrenia 1.56 1 0 0.0 0.00 1.0e+00 CISD2
Type 2 Diabetes (T2D) 2.56 1 0 0.0 0.00 1.0e+00 CISD2
Ulcerative Colitis 3.57 2 1 3.0 0.00 1.0e+00 ORMDL3 STMN3
Blood Eosinophil Count 27.87 6 6 18.2 -0.85 3.0e-02 AAGAB IL1RL2 ORMDL3 RP5-1029K10.2 SH2B3 SLC22A5
Blood Platelet Count 3.06 4 3 9.1 -0.67 3.3e-01 ORMDL3 RP5-1029K10.2 SH2B3 STMN3
Blood Red Count 2.80 4 1 3.0 -0.90 1.0e-01 ORMDL3 SH2B3 STAG3L2 STMN3
Blood White Count 15.09 5 5 15.2 -0.73 1.6e-01 ORMDL3 RP5-1029K10.2 SH2B3 SLC22A5 STMN3
Heel T-Score 1.11 3 2 6.1 0.00 1.0e+00 AAGAB NEGR1 STAG3L2
BMI 3.82 5 3 9.1 -0.90 3.8e-02 AAGAB CISD2 FTSJ2 NEGR1 STAG3L2
Height 1.26 7 5 15.2 -0.08 8.7e-01 AAGAB CISD2 FTSJ2 RP11-295M18.6 RP5-1029K10.2 SH2B3 SLC22A5
Waist Hip Ratio (WHR) 1.01 1 1 3.0 0.00 1.0e+00 AAGAB
Systolic Blood Pressure 5.34 4 2 6.1 -0.94 6.5e-02 RP5-1029K10.2 SH2B3 STAG3L2 STMN3
Smoking Status 1.50 2 0 0.0 0.00 1.0e+00 AAGAB STMN3
Allergy or Eczema 11.30 8 3 9.1 -0.78 2.2e-02 AAGAB IL1RL2 NEGR1 ORMDL3 RP5-1029K10.2 SH2B3 SLC22A5 STMN3
Cardiovascular Disease 7.88 9 4 12.1 -0.95 7.8e-05 AAGAB CISD2 FTSJ2 NEGR1 RP11-295M18.6 RP5-1029K10.2 SH2B3 STAG3L2 STMN3
Hypothyroidism (self reported) 10.56 1 1 3.0 0.00 1.0e+00 SH2B3
Respiratory disease 18.54 7 5 15.2 -0.92 3.4e-03 AAGAB IL1RL2 NEGR1 ORMDL3 RP5-1029K10.2 SLC22A5 STMN3
Type 2 Diabetes (T2D) 2.91 2 0 0.0 0.00 1.0e+00 SH2B3 STMN3
Lung FEV1/FVC ratio 2.13 5 1 3.0 0.98 2.3e-03 AAGAB IL1RL2 NEGR1 ORMDL3 RP5-1029K10.2
Lung FVC 2.90 4 2 6.1 0.02 9.8e-01 AAGAB ORMDL3 SH2B3 STMN3
Neuroticism 2.68 2 1 3.0 0.00 1.0e+00 AAGAB FTSJ2
Hair Pigment 0.19 1 1 3.0 0.00 1.0e+00 SH2B3
Tanning 0.30 2 0 0.0 0.00 1.0e+00 NEGR1 SH2B3
Hand grip strength (left) 0.94 1 0 0.0 0.00 1.0e+00 SLC22A5
Number of treatments/medications taken 9.92 9 3 9.1 0.98 3.5e-06 CISD2 FTSJ2 IL1RL2 NEGR1 RP11-295M18.6 RP5-1029K10.2 SH2B3 SLC22A5 STAG3L2
Average weekly spirits intake 1.65 1 0 0.0 0.00 1.0e+00 FTSJ2
Sensitivity / hurt feelings 2.17 1 0 0.0 0.00 1.0e+00 CISD2
Relative age of first facial hair 2.58 3 0 0.0 0.00 1.0e+00 NEGR1 SLC22A5 STAG3L2
Other serious medical condition/disability diagnosed by doctor 3.40 2 0 0.0 0.00 1.0e+00 NEGR1 STAG3L2
Systolic blood pressure, automated reading 4.23 4 1 3.0 0.98 2.4e-02 RP5-1029K10.2 SH2B3 STAG3L2 STMN3
Vitamin and mineral supplements 2.43 2 0 0.0 0.00 1.0e+00 FTSJ2 NEGR1
Medication: Metformin 3.00 1 0 0.0 0.00 1.0e+00 CISD2
Pack years adult smoking proportion 2.67 2 0 0.0 0.00 1.0e+00 STAG3L2 STMN3
Impedance of leg (right) 2.50 3 2 6.1 0.00 1.0e+00 NEGR1 RP5-1029K10.2 STAG3L2
Leg fat-free mass (left) 1.55 5 1 3.0 0.34 5.8e-01 AAGAB NEGR1 SH2B3 SLC22A5 STAG3L2
Trunk fat percentage 3.14 4 2 6.1 0.97 3.4e-02 AAGAB FTSJ2 NEGR1 STAG3L2
Hand grip strength (right) 1.17 1 0 0.0 0.00 1.0e+00 SLC22A5
Current tobacco smoking 2.84 2 1 3.0 0.00 1.0e+00 NEGR1 STMN3
Fed-up feelings 2.66 1 1 3.0 0.00 1.0e+00 SH2B3
Frequency of unenthusiasm / disinterest in last 2 weeks 2.82 1 0 0.0 0.00 1.0e+00 FTSJ2
Relative age voice broke 2.60 1 0 0.0 0.00 1.0e+00 STAG3L2
Taking other prescription medications 11.26 10 1 3.0 0.99 1.9e-07 AAGAB CISD2 FTSJ2 IL1RL2 NEGR1 ORMDL3 RP11-295M18.6 RP5-1029K10.2 SH2B3 STAG3L2
Age when periods started (menarche) 4.66 3 2 6.1 0.00 1.0e+00 AAGAB NEGR1 STAG3L2
High blood pressure 7.16 6 3 9.1 0.97 1.5e-03 AAGAB CISD2 NEGR1 RP5-1029K10.2 SH2B3 STAG3L2
Hayfever, allergic rhinitis or eczema 11.11 7 3 9.1 0.91 4.2e-03 AAGAB IL1RL2 NEGR1 ORMDL3 RP5-1029K10.2 SLC22A5 STMN3
Multivitamins +/- minerals 3.16 2 0 0.0 0.00 1.0e+00 FTSJ2 NEGR1
Stomach or abdominal pain in last month 1.19 1 0 0.0 0.00 1.0e+00 NEGR1
Medication: Atenolol 4.31 1 1 3.0 0.00 1.0e+00 SH2B3
Medication: Levothyroxine sodium 8.59 1 1 3.0 0.00 1.0e+00 SH2B3
Sitting height 1.00 2 1 3.0 0.00 1.0e+00 RP5-1029K10.2 SLC22A5
Body mass index (BMI) 3.50 4 3 9.1 0.96 4.2e-02 AAGAB FTSJ2 NEGR1 STAG3L2
Impedance of leg (left) 2.32 4 2 6.1 -0.96 4.2e-02 FTSJ2 NEGR1 RP5-1029K10.2 STAG3L2
Leg predicted mass (left) 1.57 5 1 3.0 0.35 5.7e-01 AAGAB NEGR1 SH2B3 SLC22A5 STAG3L2
Trunk fat mass 3.11 4 3 9.1 0.96 4.1e-02 AAGAB FTSJ2 NEGR1 STAG3L2
Waist circumference 3.33 4 3 9.1 0.98 2.4e-02 AAGAB FTSJ2 NEGR1 STAG3L2
Past tobacco smoking 2.61 2 0 0.0 0.00 1.0e+00 AAGAB SH2B3
Alcohol usually taken with meals 1.85 1 0 0.0 0.00 1.0e+00 NEGR1
Nervous feelings 1.68 1 0 0.0 0.00 1.0e+00 AAGAB
Forced vital capacity (FVC) 2.14 2 2 6.1 0.00 1.0e+00 AAGAB STMN3
Qualifications: None of the above 4.03 3 1 3.0 0.00 1.0e+00 NEGR1 RP5-1029K10.2 STAG3L2
Mouth/teeth dental problems 1.93 1 0 0.0 0.00 1.0e+00 STAG3L2
Heart attack 3.64 2 0 0.0 0.00 1.0e+00 RP5-1029K10.2 SH2B3
Allergy 16.66 8 5 15.2 -0.90 2.0e-03 AAGAB CISD2 IL1RL2 NEGR1 ORMDL3 RP5-1029K10.2 SLC22A5 STMN3
Diabetes (self-reported) 3.24 2 0 0.0 0.00 1.0e+00 STAG3L2 STMN3
Hayfever/allergic rhinitis (self-reported) 6.29 3 2 6.1 0.00 1.0e+00 IL1RL2 ORMDL3 RP11-295M18.6
Medication: Ramipril 5.00 5 0 0.0 1.00 3.7e-04 AAGAB CISD2 SH2B3 STAG3L2 STMN3
Medication: Simvastatin 2.70 1 0 0.0 0.00 1.0e+00 FTSJ2
Fluid intelligence score 3.02 1 1 3.0 0.00 1.0e+00 NEGR1
Illnesses of siblings 2.73 1 0 0.0 0.00 1.0e+00 SH2B3
Neuroticism score 2.35 2 0 0.0 0.00 1.0e+00 AAGAB FTSJ2
Weight 2.59 5 3 9.1 0.66 2.2e-01 AAGAB FTSJ2 NEGR1 SH2B3 STAG3L2
Impedance of arm (right) 3.06 7 2 6.1 -0.12 8.0e-01 AAGAB CISD2 NEGR1 ORMDL3 RP5-1029K10.2 SH2B3 STAG3L2
Arm fat percentage (right) 3.61 4 4 12.1 0.98 1.6e-02 AAGAB FTSJ2 NEGR1 STAG3L2
Trunk fat-free mass 1.22 3 1 3.0 0.00 1.0e+00 NEGR1 SH2B3 SLC22A5
Hip circumference 2.85 5 2 6.1 0.59 2.9e-01 AAGAB FTSJ2 NEGR1 SH2B3 STAG3L2
Alcohol intake versus 10 years previously 3.08 2 0 0.0 0.00 1.0e+00 FTSJ2 NEGR1
Father's age at death 2.74 1 1 3.0 0.00 1.0e+00 SH2B3
Worrier / anxious feelings 1.34 1 0 0.0 0.00 1.0e+00 FTSJ2
Frequency of tiredness / lethargy in last 2 weeks 2.72 2 0 0.0 0.00 1.0e+00 FTSJ2 SH2B3
Forced expiratory volume in 1-second (FEV1) 1.82 3 0 0.0 0.00 1.0e+00 AAGAB SLC22A5 STMN3
Qualifications: A levels/AS levels or equivalent 2.98 2 1 3.0 0.00 1.0e+00 FTSJ2 NEGR1
Mouth/teeth dental problems: Dentures 2.93 2 0 0.0 0.00 1.0e+00 NEGR1 STAG3L2
Asthma 17.90 5 4 12.1 0.95 1.3e-02 AAGAB IL1RL2 ORMDL3 RP5-1029K10.2 SLC22A5
Medication: Lansoprazole 1.92 1 0 0.0 0.00 1.0e+00 SH2B3
Forced expiratory volume in 1-second (FEV1), Best measure 1.68 2 0 0.0 0.00 1.0e+00 SLC22A5 STMN3
Impedance of arm (left) 3.18 7 2 6.1 -0.12 8.0e-01 AAGAB CISD2 NEGR1 ORMDL3 RP5-1029K10.2 SH2B3 STAG3L2
Arm fat mass (right) 3.37 4 3 9.1 0.97 2.9e-02 AAGAB FTSJ2 NEGR1 STAG3L2
Trunk predicted mass 1.25 3 1 3.0 0.00 1.0e+00 NEGR1 SH2B3 SLC22A5
Standing height 1.46 6 3 9.1 -0.22 6.8e-01 AAGAB CISD2 FTSJ2 RP5-1029K10.2 SH2B3 SLC22A5
Tense / 'highly strung' 0.97 1 0 0.0 0.00 1.0e+00 FTSJ2
Seen doctor (GP) for nerves, anxiety, tension or depression 5.21 3 1 3.0 0.00 1.0e+00 FTSJ2 NEGR1 STMN3
Hair/balding pattern: Pattern 4 1.57 2 0 0.0 0.00 1.0e+00 AAGAB SLC22A5
Birth weight of first child 3.95 2 1 3.0 0.00 1.0e+00 SH2B3 STAG3L2
Blood clot in the leg (DVT) 1.40 1 0 0.0 0.00 1.0e+00 SH2B3
Headache pain in last month 2.76 1 0 0.0 0.00 1.0e+00 CISD2
Medication for cholesterol, blood pressure or diabetes 5.46 4 1 3.0 -1.00 4.5e-03 CISD2 NEGR1 SH2B3 STAG3L2
Gout (self-reported) 3.64 2 0 0.0 0.00 1.0e+00 IL1RL2 SH2B3
Hypothyroidism/myxoedema (self-reported) 8.60 1 1 3.0 0.00 1.0e+00 SH2B3
Medication: Ventolin 100micrograms inhaler 9.16 4 2 6.1 0.99 1.3e-02 AAGAB IL1RL2 ORMDL3 SLC22A5
Birth weight 1.83 1 1 3.0 0.00 1.0e+00 SH2B3
Chronic bronchitis/emphysema (mother) 2.73 1 0 0.0 0.00 1.0e+00 AAGAB
High blood pressure (siblings) 2.20 1 0 0.0 0.00 1.0e+00 SH2B3
Forced vital capacity (FVC), Best measure 1.84 3 2 6.1 0.00 1.0e+00 AAGAB SLC22A5 STMN3
Body fat percentage 3.56 5 3 9.1 0.96 7.9e-03 AAGAB FTSJ2 NEGR1 STAG3L2 STMN3
Leg fat percentage (right) 3.46 5 2 6.1 0.96 7.9e-03 AAGAB FTSJ2 NEGR1 STAG3L2 STMN3
Arm fat-free mass (right) 1.74 2 2 6.1 0.00 1.0e+00 NEGR1 SH2B3
Exposure to tobacco smoke outside home 2.03 1 0 0.0 0.00 1.0e+00 SH2B3
Comparative body size at age 10 4.30 2 1 3.0 0.00 1.0e+00 AAGAB NEGR1
Worry too long after embarrassment 1.51 1 0 0.0 0.00 1.0e+00 AAGAB
Seen a psychiatrist for nerves, anxiety, tension or depression 1.55 1 0 0.0 0.00 1.0e+00 NEGR1
Wheeze or whistling in the chest in last year 8.11 6 2 6.1 0.97 1.5e-03 AAGAB IL1RL2 ORMDL3 RP5-1029K10.2 SLC22A5 STMN3
Qualifications: College or University degree 4.36 4 1 3.0 -0.31 6.9e-01 FTSJ2 NEGR1 ORMDL3 STMN3
Medication for pain relief, constipation, heartburn 3.08 3 0 0.0 0.00 1.0e+00 CISD2 FTSJ2 IL1RL2
Medication: Blood pressure 6.74 5 2 6.1 0.97 7.8e-03 CISD2 NEGR1 RP5-1029K10.2 SH2B3 STAG3L2
Medication: Allopurinol 3.09 1 0 0.0 0.00 1.0e+00 SH2B3
Medication: Seretide 50 evohaler 4.58 3 0 0.0 0.00 1.0e+00 AAGAB ORMDL3 SLC22A5
Mean time to correctly identify matches 3.20 1 1 3.0 0.00 1.0e+00 SH2B3
Whole body fat mass 3.43 4 3 9.1 0.96 3.8e-02 AAGAB FTSJ2 NEGR1 STAG3L2
Leg fat mass (right) 3.61 4 3 9.1 0.96 4.2e-02 AAGAB FTSJ2 NEGR1 STAG3L2
Arm predicted mass (right) 1.76 2 2 6.1 0.00 1.0e+00 NEGR1 SH2B3
Pulse rate, automated reading 2.06 2 1 3.0 0.00 1.0e+00 NEGR1 STAG3L2
Alcohol intake frequency. 2.91 3 1 3.0 0.00 1.0e+00 FTSJ2 NEGR1 STAG3L2
Comparative height size at age 10 1.92 4 2 6.1 -0.34 6.6e-01 AAGAB SH2B3 SLC22A5 STAG3L2
Overall health rating 3.59 4 0 0.0 1.00 1.4e-03 CISD2 FTSJ2 RP5-1029K10.2 STAG3L2
Chest pain or discomfort 3.27 2 0 0.0 0.00 1.0e+00 ORMDL3 RP5-1029K10.2
Commuting to job workplace: Car/motor vehicle 1.82 1 0 0.0 0.00 1.0e+00 NEGR1
Medication: Aspirin 4.08 2 0 0.0 0.00 1.0e+00 FTSJ2 SH2B3
Hypertension (Self-reported) 6.53 6 3 9.1 0.96 2.0e-03 AAGAB CISD2 NEGR1 RP5-1029K10.2 SH2B3 STAG3L2
Illnesses of father: Heart disease 2.09 1 0 0.0 0.00 1.0e+00 SH2B3
Smoking status: Previous 3.01 1 0 0.0 0.00 1.0e+00 SH2B3
Forced expiratory volume in 1-second (FEV1), predicted 1.93 1 0 0.0 0.00 1.0e+00 SLC22A5
Whole body fat-free mass 1.35 3 2 6.1 0.00 1.0e+00 NEGR1 SH2B3 SLC22A5
Leg fat-free mass (right) 1.44 4 1 3.0 0.26 7.4e-01 NEGR1 SH2B3 SLC22A5 STAG3L2
Arm fat percentage (left) 3.65 4 4 12.1 0.98 1.8e-02 AAGAB FTSJ2 NEGR1 STAG3L2
Average weekly red wine intake 3.36 2 0 0.0 0.00 1.0e+00 FTSJ2 NEGR1
Mood swings 2.01 2 0 0.0 0.00 1.0e+00 FTSJ2 SH2B3
Loneliness, isolation 1.81 1 0 0.0 0.00 1.0e+00 SH2B3
Long-standing illness, disability or infirmity 6.02 5 0 0.0 0.98 2.2e-03 AAGAB NEGR1 RP5-1029K10.2 SH2B3 STAG3L2
Diabetes diagnosed by doctor 3.03 3 0 0.0 0.00 1.0e+00 CISD2 SH2B3 STAG3L2
Qualifications: nursing, teaching 4.02 2 1 3.0 0.00 1.0e+00 NEGR1 SH2B3
Mouth/teeth dental problems: Mouth ulcers 1.85 1 0 0.0 0.00 1.0e+00 SH2B3
Medication for cholesterol 4.73 3 1 3.0 0.00 1.0e+00 CISD2 SH2B3 STAG3L2
Back pain experienced in last month 1.21 1 0 0.0 0.00 1.0e+00 SH2B3
Asthma (self-reported) 17.65 5 4 12.1 0.95 1.3e-02 AAGAB IL1RL2 ORMDL3 RP5-1029K10.2 SLC22A5
Osteoarthritis (self-reported) 2.72 1 0 0.0 0.00 1.0e+00 RP11-295M18.6
Medication: Aspirin 3.95 2 0 0.0 0.00 1.0e+00 CISD2 SH2B3
Medication: Gliclazide 1.73 1 0 0.0 0.00 1.0e+00 CISD2
Illnesses of father: None of the above (group 1) 2.48 1 0 0.0 0.00 1.0e+00 SH2B3
Smoking status: Current 2.72 1 0 0.0 0.00 1.0e+00 STMN3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.52 2 1 3.0 0.00 1.0e+00 ORMDL3 STMN3
Whole body water mass 1.40 3 2 6.1 0.00 1.0e+00 NEGR1 SH2B3 SLC22A5
Leg predicted mass (right) 1.44 4 1 3.0 0.27 7.3e-01 NEGR1 SH2B3 SLC22A5 STAG3L2
Arm fat mass (left) 3.46 4 3 9.1 0.97 2.5e-02 AAGAB FTSJ2 NEGR1 STAG3L2
Miserableness 3.81 2 1 3.0 0.00 1.0e+00 FTSJ2 ORMDL3
Guilty feelings 1.86 1 0 0.0 0.00 1.0e+00 FTSJ2
Mother's age at death 2.87 1 0 0.0 0.00 1.0e+00 STAG3L2
Commuting to job workplace: Public transport 2.07 1 0 0.0 0.00 1.0e+00 NEGR1
Medication: Blood pressure 4.83 3 1 3.0 0.00 1.0e+00 CISD2 SH2B3 STAG3L2
Medication: Bendroflumethiazide 2.90 1 0 0.0 0.00 1.0e+00 SH2B3
Medication: Lisinopril 3.14 1 0 0.0 0.00 1.0e+00 SH2B3
Illnesses of father: High blood pressure 1.99 1 0 0.0 0.00 1.0e+00 SH2B3
Ever smoked 1.72 1 0 0.0 0.00 1.0e+00 SH2B3
Basal metabolic rate 1.62 4 2 6.1 0.18 8.2e-01 NEGR1 SH2B3 SLC22A5 STAG3L2
Leg fat percentage (left) 3.51 5 2 6.1 0.96 8.5e-03 AAGAB FTSJ2 NEGR1 STAG3L2 STMN3
Arm fat-free mass (left) 1.88 2 2 6.1 0.00 1.0e+00 NEGR1 SH2B3
Number of operations (self-reported) 2.75 1 0 0.0 0.00 1.0e+00 NEGR1
Average weekly beer plus cider intake 1.25 1 0 0.0 0.00 1.0e+00 NEGR1
Irritability 1.81 1 0 0.0 0.00 1.0e+00 FTSJ2
Fractured/broken bones in last 5 years 2.60 1 0 0.0 0.00 1.0e+00 AAGAB
Diastolic blood pressure, automated reading 7.91 6 3 9.1 0.91 1.1e-02 AAGAB CISD2 RP5-1029K10.2 SH2B3 STAG3L2 STMN3
Ever depressed for a whole week 2.06 1 0 0.0 0.00 1.0e+00 ORMDL3
Unable to work because of sickness or disability 1.76 1 0 0.0 0.00 1.0e+00 STAG3L2
Commuting to job workplace: Cycle 2.21 1 0 0.0 0.00 1.0e+00 NEGR1
Myopia 2.82 2 0 0.0 0.00 1.0e+00 FTSJ2 ORMDL3
Vascular/heart problems diagnosed by doctor 7.88 8 3 9.1 -0.94 5.2e-04 AAGAB CISD2 FTSJ2 NEGR1 RP11-295M18.6 RP5-1029K10.2 SH2B3 STAG3L2
Cholesterol lowering medication 2.06 1 0 0.0 0.00 1.0e+00 STAG3L2
Pain experienced in last month 2.05 1 0 0.0 0.00 1.0e+00 SH2B3
Heart attack/myocardial infarction (self-reported) 3.91 2 0 0.0 0.00 1.0e+00 RP5-1029K10.2 SH2B3
Deep venous thrombosis (DVT) (self-reported) 1.33 1 0 0.0 0.00 1.0e+00 SH2B3
Pack years of smoking 2.63 2 0 0.0 0.00 1.0e+00 STAG3L2 STMN3
Impedance of whole body 2.82 7 4 12.1 -0.47 2.9e-01 AAGAB CISD2 FTSJ2 NEGR1 ORMDL3 RP5-1029K10.2 STAG3L2
Leg fat mass (left) 3.60 4 3 9.1 0.96 4.5e-02 AAGAB FTSJ2 NEGR1 STAG3L2
Arm predicted mass (left) 1.85 2 2 6.1 0.00 1.0e+00 NEGR1 SH2B3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.80
GTEx Adipose Visceral Omentum 0 0.0000 1.71
GTEx Adrenal Gland 1 0.0686 1.79
GTEx Artery Aorta 2 0.0672 1.82
GTEx Artery Coronary 0 0.0000 1.73
GTEx Artery Tibial 2 0.0532 1.84
GTEx Brain Caudate basal ganglia 0 0.0000 1.67
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.76
GTEx Brain Cerebellum 3 0.1514 1.87
GTEx Brain Cortex 1 0.0966 1.83
GTEx Brain Frontal Cortex BA9 0 0.0000 1.73
GTEx Brain Hippocampus 1 0.1908 1.86
GTEx Brain Hypothalamus 0 0.0000 1.48
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.65
GTEx Brain Putamen basal ganglia 0 0.0000 1.61
GTEx Breast Mammary Tissue 0 0.0000 1.81
GTEx Breast Mammary Tissue (Male) 1 0.0838 1.71
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.76
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.82
GTEx Cells Transformed fibroblasts 3 0.0714 1.78
GTEx Colon Sigmoid 1 0.0684 1.73
GTEx Colon Transverse 1 0.0484 1.79
GTEx Esophagus Gastroesophageal Junction 2 0.1384 1.78
GTEx Esophagus Mucosa 1 0.0301 1.80
GTEx Esophagus Muscularis 1 0.0309 1.76
GTEx Heart Atrial Appendage 0 0.0000 1.70
GTEx Heart Left Ventricle 0 0.0000 1.67
GTEx Liver 0 0.0000 1.68
GTEx Lung 2 0.0696 1.73
GTEx Muscle Skeletal 1 0.0346 1.82
GTEx Nerve Tibial 2 0.0463 1.70
GTEx Ovary 1 0.1101 1.81
GTEx Pancreas 1 0.0613 1.88
GTEx Pituitary 0 0.0000 1.73
GTEx Prostate 1 0.1198 1.86
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.86
GTEx Skin Sun Exposed Lower leg 2 0.0549 1.81
GTEx Small Intestine Terminal Ileum 1 0.2169 1.76
GTEx Spleen 0 0.0000 1.80
GTEx Stomach 0 0.0000 1.73
GTEx Testis 1 0.0317 1.77
GTEx Thyroid 1 0.0250 1.78
GTEx Uterus 1 0.1764 1.71
GTEx Vagina 0 0.0000 1.77
GTEx Whole Blood 1 0.0502 1.90
METSIM Adipose 1 0.0217 1.68
NTR Blood 0 0.0000 1.72
ROSMAP Brain Pre-frontal Cortex 4 0.0911 1.77
YFS Blood 1 0.0217 1.69
CommonMind Brain Pre-frontal Cortex 3 0.0558 1.78
TCGA Breast Tumor 0 0.0000 1.76
TCGA Breast Normal 2 0.0475 1.64
TCGA Ovarian Tumor 0 0.0000 1.57
TCGA Prostate Tumor 1 0.0289 1.71