Hub : Genes

GRIA4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.0472 0.0164 5.5e-05 0.047 0.030 0.046 0.032 0.046 1.1e-06 8.5e-05 1.2e-06 4.6e-05 1.4e-06
2 TCGA Kidney Renal Clear Cell Carcinoma 0.2975 0.0625 2.3e-12 0.130 0.104 0.114 NA 0.087 2.0e-14 1.0e-11 9.8e-13 NA 5.6e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.2 0.3 -0.5 -0.2
Bipolar Disorder or Schizophrenia 0.3 0.8 1.4 -1.2 0.4
Depressed Affect (Nagel 2018) 2.0 4.2 4.8 2.2 -1.9
Depression (Nagel 2018) 1.9 2.9 3.7 1.9 -1.5
Intelligence (Savage-Jansen 2018) 4.3 13.1 24.4 -4.9 1.3
Neuroticism (Nagel 2018) 1.4 3.2 4.0 1.6 -2.0
Schizophrenia (2018) 0.4 0.9 1.2 -1.1 0.7
Schizophrenia vs Biploar Disorder 0.3 0.4 0.9 0.9 -0.0
Worry (Nagel 2018) 0.1 0.1 0.2 0.3 -0.4
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 0.4 -0.1
Alzheimer’s Disease (in father) 2.2 2.4 4.0 0.9 2.0
Alzheimer’s Disease (including proxy) 0.2 0.3 0.4 0.6 0.6
Crohns Disease (2017) 1.1 2.4 4.7 2.2 -0.3
Irritable Bowel Disease (IBD) 0.6 1.4 2.7 1.6 0.1
Ulcerative Colitis (UC) 0.1 0.2 0.3 0.2 0.5
Major Depression (MDD) 0.5 0.6 0.7 0.7 -0.9
Reaction Time 0.6 1.1 2.1 -0.4 1.4
Verbal and Numeric Reasoning (VNR) 4.3 10.2 19.0 -4.4 1.2
Breast Cancer 0.1 0.3 0.4 -0.3 -0.7
Ovarian Cancer 1.4 1.9 3.8 -0.3 1.9
Prostate Cancer 0.9 1.2 2.2 0.5 1.5
Age at First Birth 0.3 0.5 0.9 -0.9 -0.2
Bipolar Disorder (2011) 0.2 0.2 0.4 -0.0 0.6
Body Mass Index (BMI) (2010) 0.3 0.4 0.7 -0.2 0.9
Coronary Artery Disease (CAD) 0.5 0.6 1.2 1.1 -0.2
Crohns Disease (2012) 0.6 1.0 1.7 1.3 0.6
Mean Putamen Volume 1.6 1.8 3.6 0.1 -1.9
Fasting Glucose 1.2 1.4 2.7 0.3 1.6
HbA1C 0.6 0.6 1.2 -0.0 1.1
HDL Cholesterol 0.4 0.6 1.0 1.0 0.4
LDL Cholesterol 0.7 1.1 1.8 0.7 -1.3
Lupus 1.0 1.5 2.7 0.5 -1.6
Neuroticism (2016) 0.0 0.1 0.1 -0.3 0.2
Primary Biliary Cirrhosis 2.2 3.2 5.3 2.3 1.1
Rheumatoid Arthritis 0.2 0.3 0.5 0.2 0.7
Schizophrenia (2014) 0.3 0.8 0.9 -0.8 1.0
Triglycerides 0.3 0.5 0.7 -0.5 0.8
Type 2 Diabetes (T2D) (2012) 1.1 1.2 2.0 -1.4 -0.7
Ulcerative Colitis 0.1 0.2 0.4 0.6 0.1
Blood Eosinophil Count 0.2 1.7 3.1 1.8 -0.6
Blood Platelet Count 0.1 1.4 2.4 -1.6 -0.7
Blood Red Count 0.3 2.7 2.8 1.6 -1.7
Blood White Count 0.6 4.3 7.5 2.7 1.1
Heel T-Score 0.7 5.9 10.4 -3.2 -1.2
BMI 0.7 4.0 5.4 1.6 -2.3
Height 0.0 0.6 1.1 0.3 1.1
Waist Hip Ratio (WHR) 0.7 3.0 5.8 0.5 -2.4
Systolic Blood Pressure 0.1 0.5 0.6 -0.6 -0.8
Smoking Status 2.9 6.8 12.5 3.5 1.1
Allergy or Eczema 0.5 1.2 2.0 -0.6 1.4
Cardiovascular Disease 0.2 0.7 1.4 1.2 0.2
Hypothyroidism (self reported) 0.5 1.2 1.8 1.4 0.8
Respiratory disease 0.5 1.1 1.9 0.5 -1.4
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.3 0.8 1.2
Lung FEV1/FVC ratio 1.0 4.9 8.8 1.0 3.0
Lung FVC 0.2 0.9 1.1 -1.0 0.9
Neuroticism 0.3 0.8 1.0 0.7 -1.0
Chronotype (morning person) 1.5 3.4 6.7 2.6 -0.1
Hair Pigment 0.0 1.2 2.2 1.5 0.4
Tanning 0.1 1.7 1.8 1.3 -1.3
Hand grip strength (left) 1.4 3.8 7.5 -2.7 0.4
Number of treatments/medications taken 0.1 0.1 0.1 0.3 -0.4
Average weekly spirits intake 1.9 2.4 4.7 0.3 -2.2
Sensitivity / hurt feelings 2.4 4.1 4.2 2.0 -2.1
Frequency of depressed mood in last 2 weeks 1.1 1.5 2.8 0.4 -1.7
Hearing difficulty/problems: Yes 1.6 2.5 3.1 1.8 -1.4
Relative age of first facial hair 0.6 1.3 2.0 -1.4 0.8
Other serious medical condition/disability diagnosed by doctor 3.2 4.2 6.2 2.5 1.5
Ever used hormone-replacement therapy (HRT) 0.9 1.1 1.2 1.0 -1.1
Ever had hysterectomy (womb removed) 0.6 0.7 1.3 1.1 0.2
Systolic blood pressure, automated reading 0.3 0.8 1.3 -1.2 0.5
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.5 1.2 0.5
Angina 1.5 2.0 3.2 1.8 -0.9
Medication for hormone replacement therapy 4.2 4.7 7.5 1.4 -2.7
Vitamin and mineral supplements 1.4 1.9 2.9 1.7 -0.9
Supplements: Zinc 1.1 1.2 2.4 -0.0 -1.5
Medication: Co-codamol 0.6 0.6 1.3 -0.1 1.1
Medication: Metformin 0.4 0.5 0.7 0.6 -0.8
Diabetes (father) 1.9 2.4 3.9 0.9 -2.0
Diabetes (mother) 1.3 1.7 3.3 0.4 -1.8
Severe depression (siblings) 0.1 0.2 0.2 -0.4 0.4
Pack years adult smoking proportion 1.8 2.7 5.3 2.3 -0.3
Impedance of leg (right) 0.5 2.6 5.0 2.2 0.4
Leg fat-free mass (left) 0.1 0.6 1.0 -0.4 -1.0
Trunk fat percentage 0.6 2.4 2.8 1.7 -1.4
Hand grip strength (right) 1.5 4.0 5.9 -2.4 -1.5
Townsend deprivation index at recruitment 0.2 0.2 0.3 0.6 -0.4
Current tobacco smoking 3.2 5.2 5.9 2.1 2.4
Average weekly fortified wine intake 3.4 4.0 6.9 -1.0 2.6
Maternal smoking around birth 3.4 4.9 8.1 2.8 -1.3
Fed-up feelings 0.9 1.7 1.9 1.4 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 4.1 2.0 -1.2
Relative age voice broke 0.4 0.5 0.9 -0.5 0.9
Taking other prescription medications 1.1 1.8 2.5 1.6 -1.0
Age when periods started (menarche) 0.1 0.3 0.6 0.1 0.8
Bilateral oophorectomy (both ovaries removed) 2.2 2.5 3.8 1.9 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 5.1 -2.3 -0.7
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.5 -0.1 0.7
Qualifications: CSEs or equivalent 0.2 0.2 0.4 0.3 0.6
Serious illness, injury or assault to yourself 0.6 0.7 1.4 1.2 -0.1
High blood pressure 0.1 0.4 0.6 -0.4 0.8
Hayfever, allergic rhinitis or eczema 0.7 1.5 1.9 -1.4 1.1
Multivitamins +/- minerals 1.6 2.0 3.7 -1.9 0.5
Stomach or abdominal pain in last month 0.8 1.0 1.5 -0.7 -1.2
Supplements: Glucosamine 0.0 0.0 0.0 -0.2 0.0
Diverticular disease/diverticulitis (self-reported) 2.1 2.5 2.8 1.7 -1.5
Medication: Atenolol 1.1 1.3 2.5 -0.5 -1.6
Medication: Levothyroxine sodium 0.7 1.2 2.3 1.5 0.4
Sitting height 0.0 0.0 0.0 0.0 -0.0
Chronic bronchitis/emphysema (father) 1.5 1.8 3.3 1.8 0.4
High blood pressure (mother) 0.0 0.0 0.1 -0.2 -0.2
Body mass index (BMI) 0.3 1.3 1.7 1.0 -1.3
Impedance of leg (left) 0.4 1.8 3.4 1.8 0.5
Leg predicted mass (left) 0.1 0.7 1.2 -0.4 -1.1
Trunk fat mass 0.4 1.8 2.0 1.4 -1.3
Waist circumference 0.6 2.3 2.9 1.3 -1.7
Number of incorrect matches in round 3.4 5.7 5.9 2.4 2.3
Past tobacco smoking 0.8 1.5 2.7 -1.7 0.4
Alcohol usually taken with meals 0.9 1.5 2.7 -1.7 0.5
Nervous feelings 0.6 1.2 1.4 -1.0 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.5 0.7 -0.2
Hearing difficulty/problems with background noise 0.4 0.7 1.4 1.2 -0.2
Hair/balding pattern: Pattern 2 0.0 0.0 0.0 -0.2 -0.1
Had menopause 1.0 1.3 2.5 0.3 1.6
Had other major operations 0.3 0.3 0.6 0.2 -0.8
Forced vital capacity (FVC) 0.3 1.1 1.8 -1.3 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 2.3 -1.5 -0.8
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.7 -0.0 0.8
Qualifications: None of the above 1.6 3.4 5.8 2.4 -1.0
Financial difficulties in last 2 years 2.8 3.8 4.3 2.1 -1.8
Mouth/teeth dental problems 0.4 0.7 0.9 -0.9 -0.7
Heart attack 0.0 0.1 0.1 0.3 -0.2
Allergy 0.1 0.2 0.5 0.7 0.0
Pain all over the body in last month 0.6 0.6 0.9 0.9 -0.6
Diabetes (self-reported) 0.2 0.3 0.5 0.7 -0.3
Hayfever/allergic rhinitis (self-reported) 1.7 2.2 2.9 -1.2 1.7
Medication: Ramipril 0.6 0.8 1.0 0.8 1.0
Medication: Simvastatin 0.1 0.2 0.3 0.5 0.3
Fluid intelligence score 6.6 13.8 27.3 -5.2 0.5
Illnesses of siblings 0.3 0.4 0.5 0.5 0.7
Neuroticism score 0.6 1.2 1.6 0.8 -1.3
Weight 0.2 0.7 1.0 1.0 -0.7
Impedance of arm (right) 0.0 0.1 0.2 0.4 0.0
Arm fat percentage (right) 0.4 1.5 1.8 1.1 -1.4
Trunk fat-free mass 0.0 0.1 0.2 -0.5 0.1
Hip circumference 0.1 0.6 0.6 0.8 -0.8
Time employed in main current job 0.9 1.1 1.3 1.1 0.9
Alcohol intake versus 10 years previously 1.4 2.1 3.7 0.7 -1.9
Father’s age at death 2.0 2.7 5.0 -2.2 0.6
Worrier / anxious feelings 0.3 0.6 0.9 0.5 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 2.5 1.6 -0.7
Falls in the last year 0.3 0.4 0.5 0.7 -0.5
Hair/balding pattern: Pattern 3 2.7 4.0 7.9 -0.3 2.8
Number of live births 1.7 2.4 2.4 -1.5 1.6
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 1.2 -0.8 1.1
Pulse rate 1.8 3.0 5.4 -2.3 -0.8
Happiness 0.9 1.1 1.1 -1.1 1.0
Noisy workplace 4.8 6.0 11.9 3.4 -0.1
Qualifications: A levels/AS levels or equivalent 4.3 9.6 17.9 -4.2 1.1
Serious illness, injury or assault of a close relative in last 2 years 2.8 3.2 5.1 -2.2 1.1
Mouth/teeth dental problems: Dentures 0.6 1.0 1.5 0.7 1.2
Asthma 0.3 0.7 1.3 -0.0 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.6 1.2 0.0
Medication: Cholesterol lowering 0.3 0.4 0.8 0.9 0.1
Depression (self-reported) 0.9 1.1 1.6 1.3 -0.8
Medication: Lansoprazole 2.7 3.0 4.8 2.2 -1.1
Prospective memory result 0.8 1.0 1.8 1.3 0.5
Lung cancer (father) 1.3 1.5 1.7 1.3 1.2
Illnesses of mother 0.2 0.2 0.4 -0.7 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.3 -0.4 1.1
Pulse wave Arterial Stiffness index 1.4 1.6 2.5 1.6 0.9
Impedance of arm (left) 0.0 0.2 0.3 0.5 0.2
Arm fat mass (right) 0.3 1.1 1.3 0.9 -1.1
Trunk predicted mass 0.0 0.1 0.3 -0.5 0.1
Standing height 0.0 0.4 0.7 0.3 0.8
Length of working week for main job 0.4 0.4 0.8 -0.2 0.9
Exposure to tobacco smoke at home 1.5 1.7 2.3 1.5 -1.0
Breastfed as a baby 0.5 0.6 1.2 -0.1 1.1
Tense / ‘highly strung’ 0.2 0.3 0.6 0.3 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 2.4 1.5 -0.7
Hair/balding pattern: Pattern 4 0.8 1.9 3.6 -0.3 -1.9
Birth weight of first child 1.5 2.8 3.5 -1.9 -1.5
Peak expiratory flow (PEF) 0.8 1.8 2.2 -1.2 1.5
Pulse wave reflection index 1.2 1.5 2.7 1.6 0.6
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.0 -0.8 -1.4
Loud music exposure frequency 2.7 2.9 4.0 2.0 -1.4
Qualifications: O levels/GCSEs or equivalent 3.2 5.0 9.6 -3.1 -0.7
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.4 0.6 -0.7
Blood clot in the leg (DVT) 1.8 2.3 4.5 -0.2 -2.1
Medication: Paracetamol 1.3 2.1 4.1 2.0 0.4
Headache pain in last month 1.2 2.1 3.5 -1.9 -0.8
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 0.8 -0.9 -0.7
Glaucoma (self-reported) 0.5 0.6 0.7 0.6 0.9
Gout (self-reported) 0.7 1.0 1.8 0.3 1.4
Hypothyroidism/myxoedema (self-reported) 1.1 2.1 3.1 1.8 1.1
Medication: Amlodipine 0.3 0.4 0.5 -0.7 -0.5
Medication: Ventolin 100micrograms inhaler 1.3 1.6 1.7 -1.3 -1.3
Birth weight 0.2 0.5 1.0 -1.0 -0.1
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.1 1.0 0.4
High blood pressure (siblings) 0.3 0.4 0.7 -0.4 -0.8
Forced vital capacity (FVC), Best measure 0.1 0.3 0.5 -0.7 0.3
Body fat percentage 0.5 2.0 2.6 1.6 -1.2
Leg fat percentage (right) 0.7 2.4 3.8 2.0 -1.0
Arm fat-free mass (right) 0.0 0.0 0.0 -0.0 -0.0
Exposure to tobacco smoke outside home 0.1 0.2 0.3 -0.1 0.6
Comparative body size at age 10 2.3 6.4 12.4 -3.5 0.6
Number of full brothers 0.6 0.7 1.4 1.2 0.1
Worry too long after embarrassment 0.0 0.0 0.1 -0.0 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.4 0.3 -0.7
Wheeze or whistling in the chest in last year 1.5 2.7 5.4 2.3 0.0
Number of children fathered 1.4 1.6 2.1 1.4 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 3.2 3.8 5.4 -2.3 1.5
Age at first live birth 1.3 2.3 2.9 -1.7 1.3
Pulse wave peak to peak time 1.6 1.8 2.4 -1.6 -1.1
Health satisfaction 1.4 1.8 3.5 0.3 1.9
Shortness of breath walking on level ground 2.8 3.3 5.3 2.3 1.1
Qualifications: College or University degree 3.6 11.2 22.1 -4.7 0.6
Eye problems/disorders: None of the above 2.9 3.3 5.6 1.0 -2.4
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.2 -0.5 1.5
Emphysema/chronic bronchitis 1.4 1.6 1.7 1.3 -1.2
Medication for pain relief, constipation, heartburn 1.8 3.1 5.3 -2.3 0.9
Neck or shoulder pain in last month 1.4 2.0 2.5 1.2 -1.6
Medication: Blood pressure 0.0 0.0 0.1 0.2 -0.1
Angina (self-reported) 1.9 2.5 4.1 2.0 -0.9
Migraine (self-reported) 1.0 1.3 2.3 -1.5 -0.5
Medication: Ibuprofen 1.5 1.8 3.6 1.9 0.2
Medication: Allopurinol 0.1 0.1 0.2 0.4 -0.2
Medication: Omeprazole 0.4 0.4 0.8 0.9 -0.1
Medication: Seretide 50 evohaler 6.8 7.9 8.2 2.8 -2.9
Mean time to correctly identify matches 2.0 3.7 7.5 -0.2 2.7
Heart disease (mother) 2.0 2.4 4.7 2.2 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.1 -0.4
Whole body fat mass 0.3 1.4 1.6 1.3 -1.1
Leg fat mass (right) 0.5 2.0 2.4 1.6 -1.3
Arm predicted mass (right) 0.0 0.1 0.2 -0.1 -0.4
Pulse rate, automated reading 0.3 0.9 1.6 -1.3 -0.5
Alcohol intake frequency. 1.1 2.5 4.7 2.2 -0.5
Comparative height size at age 10 0.3 1.6 2.0 1.4 1.1
Number of full sisters 0.4 0.5 0.6 0.6 0.8
Suffer from ‘nerves’ 0.1 0.1 0.2 -0.5 -0.1
Overall health rating 0.6 1.2 2.2 1.5 0.5
Chest pain or discomfort 0.4 0.6 0.9 1.0 -0.5
Had major operations 1.3 1.5 2.5 1.6 -0.7
Age at last live birth 1.3 1.8 2.0 -1.4 1.3
Family relationship satisfaction 2.5 3.1 4.8 -2.2 1.1
Leg pain on walking 1.8 2.3 4.4 2.1 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 1.8 1.4 -0.3
Commuting to job workplace: Car/motor vehicle 2.2 2.6 3.5 1.3 1.9
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 2.2 -1.5 1.1
Medication: Aspirin 1.0 1.3 1.4 -1.2 -1.1
Supplements: Vitamin C 1.6 1.8 3.6 -1.9 -0.2
Knee pain experienced in last month 0.9 1.3 1.7 1.0 -1.3
Hypertension (Self-reported) 0.4 1.1 1.6 -0.7 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.3 3.9 6.3 1.2 -2.5
Illnesses of father: Heart disease 1.0 1.4 2.1 1.4 -0.8
Illnesses of siblings: Diabetes 0.5 0.6 0.8 -0.9 -0.6
Smoking status: Previous 1.5 2.3 2.8 1.3 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.0 1.4 0.9
Whole body fat-free mass 0.0 0.2 0.2 -0.5 -0.3
Leg fat-free mass (right) 0.2 0.9 1.0 -1.0 -0.9
Arm fat percentage (left) 0.3 1.2 1.2 1.1 -1.1
Average weekly red wine intake 1.5 2.3 4.3 -2.1 -0.5
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.5 0.7 0.3
Mood swings 2.3 4.1 4.6 2.1 -1.9
Loneliness, isolation 0.8 1.1 1.9 1.4 -0.5
Long-standing illness, disability or infirmity 0.8 1.2 2.1 1.5 0.6
Ever had bowel cancer screening 0.1 0.1 0.1 0.2 -0.3
Diabetes diagnosed by doctor 0.9 1.5 2.3 1.5 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.3 -0.6 0.2
Friendships satisfaction 0.8 1.0 2.1 0.1 1.4
Qualifications: nursing, teaching 0.5 0.8 1.2 -0.7 1.1
Commuting to job workplace: Walk 0.3 0.3 0.4 -0.7 -0.5
Eye problems/disorders: Cataract 3.2 3.7 4.8 -1.6 2.2
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 -0.1 -0.5
Medication for cholesterol 0.1 0.2 0.4 -0.1 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 1.8 -0.3 1.3
Back pain experienced in last month 0.6 0.9 1.7 1.3 0.4
Mineral and other dietary supplements 0.8 1.1 1.6 0.7 -1.2
Breast cancer (self-reported) 0.3 0.4 0.6 -0.8 0.5
Asthma (self-reported) 0.3 0.5 1.0 -0.1 -1.0
Osteoporosis (self-reported) 0.2 0.2 0.3 0.6 0.3
Osteoarthritis (self-reported) 0.1 0.1 0.2 -0.4 -0.2
Medication: Aspirin 1.7 2.3 2.4 -1.6 -1.4
Medication: Gliclazide 1.1 1.3 2.5 -0.3 1.6
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 -0.3 0.4
Smoking status: Current 3.2 5.0 6.1 2.0 2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.5 -0.7 0.5
Whole body water mass 0.0 0.1 0.2 -0.4 -0.3
Leg predicted mass (right) 0.2 0.9 1.0 -1.0 -0.9
Arm fat mass (left) 0.2 0.9 0.9 1.0 -1.0
Number of self-reported non-cancer illnesses 1.2 2.0 3.8 2.0 0.4
Average weekly champagne plus white wine intake 0.9 1.3 2.4 -1.5 0.4
Miserableness 1.5 2.5 4.6 0.7 -2.1
Guilty feelings 0.2 0.3 0.5 0.4 -0.7
Wears glasses or contact lenses 0.1 0.1 0.1 -0.3 -0.3
Ever taken oral contraceptive pill 1.3 1.5 2.2 -0.8 -1.5
Hearing aid user 1.4 1.5 2.8 1.7 0.5
Mother’s age at death 2.6 3.2 4.7 -2.2 1.4
Financial situation satisfaction 0.8 1.0 1.9 0.4 1.4
Tinnitus: Yes, now most or all of the time 1.3 1.5 3.1 1.8 0.1
Commuting to job workplace: Public transport 1.6 2.0 2.1 -1.5 -1.3
Eye problems/disorders: Glaucoma 1.7 2.0 3.6 0.6 1.9
Medication: Blood pressure 0.5 0.9 1.3 -1.1 0.8
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.5 0.7 -0.5
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.2 -1.1 0.2
High cholesterol (Self-reported) 0.3 0.5 0.6 0.8 0.7
Medication: Bendroflumethiazide 0.7 1.1 1.8 -1.3 0.6
Medication: Paracetamol 1.4 2.1 2.3 1.5 1.4
Medication: Lisinopril 1.4 1.9 3.7 1.9 0.2
Medication: Atorvastatin 0.0 0.0 0.0 -0.1 0.0
Illnesses of father: High blood pressure 3.7 4.5 8.1 -1.0 -2.8
Alcohol drinker status: Never 0.7 0.8 1.3 1.1 -0.5
Ever smoked 0.1 0.2 0.2 0.5 -0.3
Basal metabolic rate 0.0 0.1 0.3 -0.1 -0.5
Leg fat percentage (left) 0.5 1.7 2.9 1.7 -0.8
Arm fat-free mass (left) 0.0 0.0 0.0 0.2 -0.1
Number of operations (self-reported) 1.9 2.9 5.7 2.4 -0.1
Average weekly beer plus cider intake 0.7 1.0 1.7 1.3 -0.6
Irritability 3.6 6.2 6.7 2.6 -2.4
Risk taking 1.1 1.6 2.6 1.6 -0.7
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.3 -0.3 -1.5
Fractured/broken bones in last 5 years 0.7 0.9 1.3 0.8 -1.1
Age started oral contraceptive pill 0.9 1.1 1.8 -1.4 0.6
Diastolic blood pressure, automated reading 0.8 2.4 4.4 -2.1 -0.6
Ever depressed for a whole week 0.6 0.7 0.8 0.8 -0.9
Unable to work because of sickness or disability 2.2 2.8 5.2 2.3 0.6
Commuting to job workplace: Cycle 0.4 0.5 0.7 -0.5 0.9
Myopia 0.7 1.1 2.1 -1.4 0.2
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.8 0.3 -0.9
Cholesterol lowering medication 0.0 0.1 0.1 0.2 0.2
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 2.7 1.7 -0.0
Pain experienced in last month 1.2 2.0 3.3 -0.8 1.8
Supplements: Calcium 2.5 2.7 5.4 -0.1 2.3
Basal cell carcinoma (self-reported) 0.0 0.1 0.1 0.0 -0.3
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.0 0.1 -0.1
Deep venous thrombosis (DVT) (self-reported) 1.6 2.0 4.0 -0.2 -2.0
Heart disease (siblings) 0.9 1.1 2.2 1.5 -0.0
Alcohol drinker status: Previous 2.3 2.6 4.5 2.1 0.8
Pack years of smoking 1.4 2.0 4.0 2.0 -0.1
Impedance of whole body 0.2 1.3 2.4 1.6 0.3
Leg fat mass (left) 0.4 1.5 1.8 1.3 -1.1
Arm predicted mass (left) 0.0 0.0 0.0 0.0 0.0