Hub : Traits :

Fluid intelligence score

432 significantly associated models · 101 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 31402148 32762733 1 1 1.2e-09 3.2e-09 1.0e+00 100 PEF1
2 1 41130424 42542658 1 1 3.4e-09 5.0e-10 2.8e-05 55 FOXO6
3 1 43152610 45153116 6 2 7.9e-10 1.7e-10 6.0e-02 91 ST3GAL3
4 1 71163715 73435171 1 1 1.4e-10 5.2e-09 1.2e-01 93 NEGR1
5 1 109316076 110716511 1 1 3.0e-07 3.6e-08 1.9e-02 82 SYPL2
6 2 70804467 72356449 1 1 2.8e-08 2.1e-08 1.0e+00 100 ZNF638
7 2 72774203 74187703 2 1 3.9e-09 2.5e-07 7.3e-02 88 FBXO41
8 2 99468341 101731705 2 2 1.4e-08 1.1e-07 1.2e-01 92 AFF3 CHST10
9 2 117979194 119470084 1 1 6.8e-08 7.3e-06 1.7e-01 91 CCDC93
10 2 161297929 162790882 1 1 5.4e-10 1.5e-09 1.0e+00 100 TANK
11 3 23234618 26329265 2 2 2.2e-07 9.7e-12 1.6e-05 60 NKIRAS1 RARB
12 3 48702606 50932324 15 1 7.5e-17 1.5e-16 1.0e+00 100 UBA7
13 3 52148483 53623102 2 1 2.0e-07 6.5e-08 6.6e-02 88 TMEM110
14 4 17104059 18507692 1 1 1.1e-08 3.4e-07 5.6e-01 99 DCAF16
15 4 105598022 107092169 1 1 9.6e-13 3.0e-14 2.1e-03 84 PPA2
16 5 138933151 140378983 1 1 1.2e-07 3.6e-06 8.8e-01 100 PFDN1
17 6 108183628 109704062 1 1 3.3e-08 4.6e-10 2.0e-03 76 FOXO3
18 8 144838590 146293414 3 1 8.7e-08 2.6e-07 6.1e-02 87 HSF1
19 10 102853189 104242886 1 1 3.6e-07 9.7e-10 7.7e-05 58 NPM3
20 10 133089003 134482926 1 1 1.9e-07 6.8e-05 1.7e-02 64 BNIP3
21 11 16343081 18068163 2 1 9.3e-09 4.6e-07 2.8e-02 81 NUCB2
22 11 46622392 48559571 5 1 1.3e-08 6.5e-08 6.6e-01 99 MTCH2
23 11 104797451 106543882 1 1 1.7e-07 4.4e-08 7.8e-02 90 GRIA4
24 12 122713991 124158455 1 1 2.2e-07 3.4e-07 4.0e-01 97 ABCB9
25 14 103289637 104859419 2 1 2.7e-07 1.2e-07 1.6e-02 79 RP11-73M18.8
26 16 27412414 29595483 26 1 1.6e-12 8.8e-11 9.2e-02 93 SULT1A1
27 16 30726248 32137965 2 1 2.4e-07 5.2e-05 7.8e-01 100 ITGAD
28 16 52772129 54235440 2 1 4.6e-09 5.7e-09 3.5e-01 97 AKTIP
29 17 34157655 35644076 3 1 9.7e-08 2.5e-07 5.0e-01 98 GGNBP2
30 17 43315547 43913030 1 1 3.0e-07 2.7e-05 3.4e-01 95 MAPT
31 17 55903829 57989860 5 1 8.3e-09 2.1e-08 8.6e-02 91 TRIM37
32 18 4548348 5945376 1 1 5.1e-09 2.4e-09 1.0e+00 100 LINC00667
33 20 33129164 34556216 1 1 4.0e-07 1.3e-05 4.1e-01 96 MMP24
34 20 57934675 59346576 1 1 3.8e-07 5.4e-07 2.6e-07 -6 C20orf197
35 21 18271223 19680363 1 1 1.9e-07 2.4e-08 1.0e+00 100 BTG3
36 22 39101079 40571499 2 2 3.5e-08 1.1e-08 1.0e+00 100 MGAT3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.75 2 2 6.1 0.00 1.0e+00 SULT1A1 UBA7
Irritable Bowel Disease (IBD) 2.10 2 2 6.1 0.00 1.0e+00 SULT1A1 UBA7
Ulcerative Colitis (UC) 2.15 2 2 6.1 0.00 1.0e+00 SULT1A1 UBA7
Major Depression (MDD) 2.51 1 1 3.0 0.00 1.0e+00 NEGR1
Reaction Time 2.58 4 3 9.1 0.59 4.1e-01 FOXO3 HSF1 PFDN1 ZNF638
Verbal and Numeric Reasoning (VNR) 13.92 36 28 84.8 -0.99 1.2e-30 ABCB9 AFF3 AKTIP BTG3 C20orf197 CCDC93 CHST10 DCAF16 FBXO41 FOXO3 FOXO6 GGNBP2 GRIA4 HSF1 ITGAD LINC00667 MAPT MGAT3 MMP24 MTCH2 NEGR1 NKIRAS1 NPM3 PEF1 PFDN1 PPA2 RARB RP11-73M18.8 ST3GAL3 SULT1A1 SYPL2 TANK TMEM110 TRIM37 UBA7 ZNF638
Breast Cancer 1.10 2 0 0.0 0.00 1.0e+00 MAPT UBA7
Ovarian Cancer 1.30 1 1 3.0 0.00 1.0e+00 MAPT
Prostate Cancer 1.46 1 0 0.0 0.00 1.0e+00 UBA7
Age at First Birth 3.35 3 1 3.0 0.00 1.0e+00 C20orf197 CHST10 UBA7
Body Mass Index (BMI) (2010) 3.28 3 3 9.1 0.00 1.0e+00 MTCH2 NEGR1 SULT1A1
Crohns Disease (2012) 2.01 2 2 6.1 0.00 1.0e+00 SULT1A1 UBA7
HDL Cholesterol 1.94 1 1 3.0 0.00 1.0e+00 MTCH2
LDL Cholesterol 1.97 1 1 3.0 0.00 1.0e+00 SYPL2
Neuroticism 1.83 2 0 0.0 0.00 1.0e+00 MAPT TANK
Schizophrenia 2.88 5 3 9.1 0.31 6.1e-01 ABCB9 MGAT3 RP11-73M18.8 ST3GAL3 TMEM110
Ulcerative Colitis 2.26 2 0 0.0 0.00 1.0e+00 TMEM110 UBA7
Blood Eosinophil Count 0.96 3 3 9.1 0.00 1.0e+00 ABCB9 MAPT UBA7
Blood Platelet Count 1.22 8 6 18.2 0.36 3.8e-01 ABCB9 DCAF16 HSF1 ITGAD MTCH2 RARB ST3GAL3 SULT1A1
Blood Red Count 1.67 10 5 15.2 0.17 6.4e-01 ABCB9 AFF3 CHST10 HSF1 MAPT RP11-73M18.8 ST3GAL3 SULT1A1 TMEM110 UBA7
Blood White Count 1.91 10 6 18.2 0.48 1.3e-01 DCAF16 FOXO6 MGAT3 MTCH2 NPM3 PPA2 RP11-73M18.8 SULT1A1 UBA7 ZNF638
Heel T-Score 1.69 8 6 18.2 -0.23 5.9e-01 ABCB9 CCDC93 DCAF16 MAPT MMP24 NEGR1 UBA7 ZNF638
BMI 4.23 12 8 24.2 0.48 1.1e-01 AFF3 CHST10 FOXO3 GGNBP2 MMP24 MTCH2 NEGR1 PEF1 PFDN1 SULT1A1 SYPL2 UBA7
Height 5.01 16 13 39.4 -0.52 3.1e-02 ABCB9 AKTIP DCAF16 FOXO3 ITGAD MAPT MGAT3 MMP24 MTCH2 NKIRAS1 NUCB2 PEF1 PPA2 RP11-73M18.8 ST3GAL3 ZNF638
Waist Hip Ratio (WHR) 1.85 7 3 9.1 -0.45 2.7e-01 ABCB9 AKTIP GGNBP2 MAPT MGAT3 MMP24 NUCB2
Systolic Blood Pressure 1.97 7 4 12.1 0.48 2.8e-01 DCAF16 FBXO41 FOXO3 MAPT NUCB2 UBA7 ZNF638
Smoking Status 2.89 5 2 6.1 0.69 2.0e-01 MTCH2 NUCB2 RARB ST3GAL3 TANK
Allergy or Eczema 1.54 4 2 6.1 -0.54 4.6e-01 ABCB9 GGNBP2 NEGR1 SULT1A1
Cardiovascular Disease 1.89 4 3 9.1 0.34 6.6e-01 DCAF16 FBXO41 HSF1 NEGR1
Hypothyroidism (self reported) 1.60 2 1 3.0 0.00 1.0e+00 MTCH2 TANK
Type 2 Diabetes (T2D) 2.32 3 0 0.0 0.00 1.0e+00 AKTIP HSF1 UBA7
Lung FEV1/FVC ratio 2.51 8 5 15.2 -0.53 1.7e-01 BTG3 FOXO3 MAPT NEGR1 NKIRAS1 PEF1 PPA2 RARB
Lung FVC 2.74 11 7 21.2 -0.18 6.0e-01 ABCB9 BTG3 DCAF16 FOXO3 FOXO6 HSF1 MAPT MMP24 PPA2 SULT1A1 UBA7
Neuroticism 2.31 5 2 6.1 0.60 2.8e-01 BTG3 MAPT MTCH2 TMEM110 UBA7
Chronotype (morning person) 2.00 2 1 3.0 0.00 1.0e+00 MTCH2 TRIM37
Hair Pigment 0.21 5 3 9.1 0.21 7.3e-01 ABCB9 FOXO3 MMP24 MTCH2 TRIM37
Tanning 0.30 2 1 3.0 0.00 1.0e+00 MMP24 PFDN1
Hand grip strength (left) 3.04 7 5 15.2 0.58 1.8e-01 DCAF16 MAPT MMP24 MTCH2 NPM3 PEF1 ZNF638
Number of treatments/medications taken 2.63 5 1 3.0 -0.66 2.3e-01 DCAF16 FBXO41 NEGR1 TANK UBA7
Sensitivity / hurt feelings 2.40 2 1 3.0 0.00 1.0e+00 BTG3 MAPT
Frequency of depressed mood in last 2 weeks 1.76 1 0 0.0 0.00 1.0e+00 MTCH2
Relative age of first facial hair 2.01 2 1 3.0 0.00 1.0e+00 FOXO3 MAPT
Ever used hormone-replacement therapy (HRT) 1.50 1 0 0.0 0.00 1.0e+00 MTCH2
Systolic blood pressure, automated reading 1.74 5 2 6.1 -0.68 2.0e-01 DCAF16 FBXO41 MAPT PPA2 UBA7
Medication: Co-codamol 1.62 1 0 0.0 0.00 1.0e+00 UBA7
Pack years adult smoking proportion 2.24 2 0 0.0 0.00 1.0e+00 BNIP3 SYPL2
Impedance of leg (right) 2.24 12 6 18.2 0.04 9.1e-01 AKTIP FOXO3 GGNBP2 MAPT MMP24 MTCH2 NEGR1 NUCB2 PPA2 SULT1A1 SYPL2 UBA7
Leg fat-free mass (left) 4.50 14 12 36.4 0.16 5.6e-01 ABCB9 AKTIP DCAF16 FOXO3 GGNBP2 MGAT3 MMP24 NEGR1 PEF1 PPA2 SULT1A1 SYPL2 UBA7 ZNF638
Trunk fat percentage 3.46 9 6 18.2 -0.62 7.6e-02 CHST10 FOXO3 GGNBP2 MAPT MTCH2 NEGR1 RARB SULT1A1 UBA7
Hand grip strength (right) 2.99 8 3 9.1 0.58 1.4e-01 DCAF16 MAPT MMP24 MTCH2 NPM3 PEF1 SULT1A1 ZNF638
Current tobacco smoking 2.30 2 0 0.0 0.00 1.0e+00 MTCH2 ST3GAL3
Maternal smoking around birth 2.88 1 1 3.0 0.00 1.0e+00 GGNBP2
Fed-up feelings 2.17 2 1 3.0 0.00 1.0e+00 MAPT UBA7
Relative age voice broke 1.95 2 1 3.0 0.00 1.0e+00 FOXO3 MAPT
Taking other prescription medications 2.22 1 1 3.0 0.00 1.0e+00 UBA7
Age when periods started (menarche) 3.10 4 4 12.1 -0.61 3.9e-01 FOXO3 MTCH2 NEGR1 ST3GAL3
Heel bone mineral density (BMD) T-score, automated (left) 1.45 2 0 0.0 0.00 1.0e+00 DCAF16 UBA7
Qualifications: CSEs or equivalent 3.38 3 0 0.0 0.00 1.0e+00 FOXO6 ST3GAL3 UBA7
High blood pressure 1.69 4 1 3.0 -0.49 5.1e-01 AKTIP DCAF16 FBXO41 NEGR1
Hayfever, allergic rhinitis or eczema 1.55 3 0 0.0 0.00 1.0e+00 ABCB9 GGNBP2 NEGR1
Sitting height 5.65 12 10 30.3 0.72 7.9e-03 ABCB9 AKTIP DCAF16 FOXO3 MAPT MGAT3 MMP24 MTCH2 PEF1 PPA2 ST3GAL3 ZNF638
High blood pressure (mother) 1.42 1 0 0.0 0.00 1.0e+00 GGNBP2
Body mass index (BMI) 3.91 9 7 21.2 -0.62 7.4e-02 AFF3 CHST10 DCAF16 FOXO3 GGNBP2 MTCH2 NEGR1 SULT1A1 UBA7
Impedance of leg (left) 2.34 11 7 21.2 -0.15 6.6e-01 AKTIP GGNBP2 MAPT MGAT3 MMP24 NEGR1 NUCB2 PPA2 SULT1A1 SYPL2 UBA7
Leg predicted mass (left) 4.52 14 12 36.4 0.17 5.5e-01 ABCB9 AKTIP DCAF16 FOXO3 GGNBP2 MGAT3 MMP24 NEGR1 PEF1 PPA2 SULT1A1 SYPL2 UBA7 ZNF638
Trunk fat mass 3.58 9 7 21.2 -0.53 1.4e-01 CHST10 FOXO3 GGNBP2 MMP24 MTCH2 NEGR1 RARB SULT1A1 UBA7
Waist circumference 3.65 9 6 18.2 -0.52 1.5e-01 AFF3 CHST10 FOXO3 GGNBP2 MMP24 MTCH2 NEGR1 SULT1A1 UBA7
Number of incorrect matches in round 2.31 1 1 3.0 0.00 1.0e+00 NPM3
Past tobacco smoking 2.61 3 0 0.0 0.00 1.0e+00 NUCB2 RARB TANK
Alcohol usually taken with meals 2.93 3 0 0.0 0.00 1.0e+00 CHST10 NEGR1 SULT1A1
Nervous feelings 2.02 2 2 6.1 0.00 1.0e+00 MAPT TMEM110
Frequency of tenseness / restlessness in last 2 weeks 1.68 2 0 0.0 0.00 1.0e+00 MAPT TMEM110
Hearing difficulty/problems with background noise 1.60 1 0 0.0 0.00 1.0e+00 MAPT
Hair/balding pattern: Pattern 2 1.22 1 0 0.0 0.00 1.0e+00 MAPT
Had other major operations 2.04 1 0 0.0 0.00 1.0e+00 PPA2
Forced vital capacity (FVC) 3.83 8 4 12.1 0.73 4.1e-02 BTG3 DCAF16 FOXO6 MAPT MTCH2 PPA2 UBA7 ZNF638
Heel bone mineral density (BMD) T-score, automated (right) 1.28 2 0 0.0 0.00 1.0e+00 DCAF16 UBA7
Qualifications: None of the above 7.30 15 10 30.3 -0.99 1.8e-12 ABCB9 AKTIP BNIP3 CHST10 DCAF16 FOXO3 GGNBP2 NEGR1 NPM3 PPA2 ST3GAL3 SULT1A1 SYPL2 TANK UBA7
Allergy 1.55 2 1 3.0 0.00 1.0e+00 ABCB9 NEGR1
Diabetes (self-reported) 2.21 2 0 0.0 0.00 1.0e+00 AKTIP UBA7
Medication: Simvastatin 1.39 1 0 0.0 0.00 1.0e+00 DCAF16
Illnesses of siblings 2.16 1 0 0.0 0.00 1.0e+00 ST3GAL3
Neuroticism score 2.19 4 1 3.0 0.07 9.3e-01 MAPT MTCH2 TMEM110 UBA7
Weight 4.18 13 10 30.3 0.02 9.4e-01 AFF3 AKTIP DCAF16 FOXO3 GGNBP2 MGAT3 MMP24 NEGR1 PEF1 PPA2 SULT1A1 UBA7 ZNF638
Impedance of arm (right) 2.42 10 5 15.2 0.33 3.5e-01 AFF3 FOXO3 GGNBP2 MAPT MMP24 NEGR1 NUCB2 PEF1 SYPL2 UBA7
Arm fat percentage (right) 3.98 10 6 18.2 -0.68 3.2e-02 AFF3 CHST10 DCAF16 FOXO3 GGNBP2 MTCH2 NEGR1 RARB SULT1A1 UBA7
Trunk fat-free mass 5.15 14 11 33.3 0.37 1.8e-01 ABCB9 AKTIP DCAF16 FOXO3 MGAT3 MMP24 MTCH2 NEGR1 PEF1 PPA2 SULT1A1 SYPL2 UBA7 ZNF638
Hip circumference 3.84 11 8 24.2 -0.37 2.6e-01 ABCB9 AKTIP DCAF16 FOXO3 GGNBP2 MMP24 MTCH2 NEGR1 PEF1 SULT1A1 UBA7
Alcohol intake versus 10 years previously 2.33 2 1 3.0 0.00 1.0e+00 NEGR1 UBA7
Father's age at death 1.91 1 0 0.0 0.00 1.0e+00 UBA7
Worrier / anxious feelings 1.52 2 0 0.0 0.00 1.0e+00 MAPT TMEM110
Frequency of tiredness / lethargy in last 2 weeks 1.88 1 0 0.0 0.00 1.0e+00 AFF3
Hair/balding pattern: Pattern 3 2.16 1 1 3.0 0.00 1.0e+00 MAPT
Forced expiratory volume in 1-second (FEV1) 3.94 7 4 12.1 0.89 7.8e-03 DCAF16 MAPT MTCH2 PEF1 PPA2 RARB UBA7
Pulse rate 1.43 2 1 3.0 0.00 1.0e+00 AKTIP MMP24
Noisy workplace 3.34 1 0 0.0 0.00 1.0e+00 SYPL2
Qualifications: A levels/AS levels or equivalent 8.18 18 7 21.2 0.97 6.5e-12 ABCB9 AKTIP CHST10 DCAF16 FBXO41 FOXO6 GRIA4 MAPT MGAT3 NEGR1 NPM3 PEF1 PPA2 RP11-73M18.8 ST3GAL3 SULT1A1 TANK UBA7
Mouth/teeth dental problems: Dentures 1.54 1 0 0.0 0.00 1.0e+00 UBA7
Asthma 1.35 1 0 0.0 0.00 1.0e+00 AFF3
Prospective memory result 3.56 2 0 0.0 0.00 1.0e+00 PEF1 ZNF638
Illnesses of mother 1.40 1 0 0.0 0.00 1.0e+00 GGNBP2
Forced expiratory volume in 1-second (FEV1), Best measure 4.11 5 4 12.1 0.90 3.7e-02 DCAF16 MAPT MTCH2 PPA2 UBA7
Impedance of arm (left) 2.41 10 5 15.2 0.32 3.7e-01 AFF3 FOXO3 GGNBP2 MAPT MMP24 NEGR1 NUCB2 PEF1 SYPL2 UBA7
Arm fat mass (right) 3.92 9 6 18.2 -0.54 1.4e-01 AFF3 CHST10 FOXO3 GGNBP2 MMP24 MTCH2 NEGR1 SULT1A1 UBA7
Trunk predicted mass 5.17 14 11 33.3 0.37 1.8e-01 ABCB9 AKTIP DCAF16 FOXO3 MGAT3 MMP24 MTCH2 NEGR1 PEF1 PPA2 SULT1A1 SYPL2 UBA7 ZNF638
Standing height 5.19 15 12 36.4 0.48 5.7e-02 ABCB9 AKTIP DCAF16 FOXO3 MAPT MGAT3 MMP24 MTCH2 NKIRAS1 NUCB2 PEF1 PPA2 RP11-73M18.8 SULT1A1 ZNF638
Exposure to tobacco smoke at home 1.80 1 0 0.0 0.00 1.0e+00 UBA7
Breastfed as a baby 1.93 2 0 0.0 0.00 1.0e+00 ABCB9 MTCH2
Seen doctor (GP) for nerves, anxiety, tension or depression 2.71 2 1 3.0 0.00 1.0e+00 NEGR1 RP11-73M18.8
Hair/balding pattern: Pattern 4 2.46 1 1 3.0 0.00 1.0e+00 MAPT
Birth weight of first child 2.35 2 1 3.0 0.00 1.0e+00 DCAF16 PPA2
Peak expiratory flow (PEF) 2.89 8 3 9.1 0.98 3.1e-05 DCAF16 FOXO3 MAPT MMP24 MTCH2 PEF1 PPA2 RARB
Ever highly irritable/argumentative for 2 days 1.84 1 0 0.0 0.00 1.0e+00 UBA7
Qualifications: O levels/GCSEs or equivalent 4.67 4 2 6.1 0.99 1.4e-02 ABCB9 MAPT MGAT3 ST3GAL3
Medication: Paracetamol 2.84 1 1 3.0 0.00 1.0e+00 MAPT
Headache pain in last month 1.67 1 1 3.0 0.00 1.0e+00 MAPT
Medication for cholesterol, blood pressure or diabetes 1.60 1 0 0.0 0.00 1.0e+00 UBA7
Gout (self-reported) 1.47 1 1 3.0 0.00 1.0e+00 TMEM110
Hypothyroidism/myxoedema (self-reported) 1.55 1 0 0.0 0.00 1.0e+00 TANK
Medication: Amlodipine 1.47 1 0 0.0 0.00 1.0e+00 TRIM37
Medication: Ventolin 100micrograms inhaler 1.53 2 0 0.0 0.00 1.0e+00 AFF3 UBA7
Birth weight 2.20 3 1 3.0 0.00 1.0e+00 DCAF16 MTCH2 PPA2
Chronic bronchitis/emphysema (mother) 2.37 2 0 0.0 0.00 1.0e+00 RARB UBA7
High blood pressure (siblings) 2.07 2 0 0.0 0.00 1.0e+00 DCAF16 TANK
Forced vital capacity (FVC), Best measure 4.16 8 5 15.2 0.65 8.0e-02 AKTIP DCAF16 FOXO6 MAPT MTCH2 PPA2 UBA7 ZNF638
Body fat percentage 3.75 9 5 15.2 -0.67 4.9e-02 CHST10 DCAF16 FOXO3 GGNBP2 MTCH2 NEGR1 RARB SULT1A1 UBA7
Leg fat percentage (right) 4.01 10 7 21.2 -0.68 3.0e-02 AFF3 BNIP3 CHST10 DCAF16 FOXO3 GGNBP2 MTCH2 NEGR1 SULT1A1 UBA7
Arm fat-free mass (right) 4.79 14 10 30.3 0.17 5.5e-01 ABCB9 AKTIP DCAF16 FOXO3 GGNBP2 MGAT3 MMP24 NEGR1 PEF1 PPA2 SULT1A1 SYPL2 UBA7 ZNF638
Exposure to tobacco smoke outside home 1.48 1 0 0.0 0.00 1.0e+00 UBA7
Comparative body size at age 10 3.17 5 4 12.1 -0.40 5.1e-01 GGNBP2 MTCH2 NEGR1 SULT1A1 SYPL2
Worry too long after embarrassment 2.08 2 0 0.0 0.00 1.0e+00 PFDN1 PPA2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.81 1 0 0.0 0.00 1.0e+00 RP11-73M18.8
Wheeze or whistling in the chest in last year 2.41 2 1 3.0 0.00 1.0e+00 AFF3 UBA7
Age at first live birth 3.27 3 1 3.0 0.00 1.0e+00 C20orf197 DCAF16 UBA7
Health satisfaction 1.77 1 0 0.0 0.00 1.0e+00 UBA7
Qualifications: College or University degree 9.77 27 20 60.6 0.98 8.4e-20 ABCB9 AFF3 AKTIP BNIP3 C20orf197 CCDC93 CHST10 DCAF16 FBXO41 FOXO3 FOXO6 GGNBP2 GRIA4 HSF1 MAPT MGAT3 NEGR1 NKIRAS1 NPM3 PFDN1 PPA2 RP11-73M18.8 ST3GAL3 SULT1A1 SYPL2 TANK UBA7
Medication for pain relief, constipation, heartburn 2.26 1 1 3.0 0.00 1.0e+00 MAPT
Medication: Blood pressure 1.51 2 0 0.0 0.00 1.0e+00 DCAF16 FBXO41
Medication: Allopurinol 1.54 1 0 0.0 0.00 1.0e+00 TMEM110
Medication: Seretide 50 evohaler 1.50 1 0 0.0 0.00 1.0e+00 UBA7
Mean time to correctly identify matches 2.51 3 2 6.1 0.00 1.0e+00 FOXO3 PFDN1 ZNF638
Whole body fat mass 3.77 10 7 21.2 -0.53 1.1e-01 AFF3 CHST10 FOXO3 GGNBP2 MMP24 MTCH2 NEGR1 RARB SULT1A1 UBA7
Leg fat mass (right) 3.91 10 7 21.2 -0.49 1.5e-01 AFF3 CHST10 FOXO3 GGNBP2 MMP24 MTCH2 NEGR1 PEF1 SULT1A1 UBA7
Arm predicted mass (right) 4.81 14 10 30.3 0.16 5.6e-01 ABCB9 AKTIP DCAF16 FOXO3 GGNBP2 MGAT3 MMP24 NEGR1 PEF1 PPA2 SULT1A1 SYPL2 UBA7 ZNF638
Pulse rate, automated reading 1.68 3 3 9.1 0.00 1.0e+00 AKTIP NEGR1 UBA7
Alcohol intake frequency. 3.32 8 3 9.1 -0.77 2.7e-02 ABCB9 BNIP3 MAPT MTCH2 NEGR1 PPA2 SULT1A1 UBA7
Comparative height size at age 10 4.43 13 11 33.3 0.40 1.8e-01 ABCB9 AKTIP DCAF16 FOXO3 MAPT MMP24 MTCH2 NUCB2 PPA2 RP11-73M18.8 ST3GAL3 SULT1A1 ZNF638
Suffer from 'nerves' 2.70 3 2 6.1 0.00 1.0e+00 MTCH2 SULT1A1 TMEM110
Overall health rating 2.79 5 1 3.0 -0.99 1.1e-03 AKTIP DCAF16 RARB TANK UBA7
Age at last live birth 2.57 1 1 3.0 0.00 1.0e+00 UBA7
Leg pain on walking 2.07 1 0 0.0 0.00 1.0e+00 UBA7
Commuting to job workplace: Car/motor vehicle 1.82 2 0 0.0 0.00 1.0e+00 CHST10 NEGR1
Knee pain experienced in last month 1.82 1 0 0.0 0.00 1.0e+00 MMP24
Hypertension (Self-reported) 1.57 4 1 3.0 -0.53 4.7e-01 AKTIP DCAF16 FBXO41 NEGR1
Forced expiratory volume in 1-second (FEV1), predicted 3.15 5 1 3.0 0.78 1.2e-01 DCAF16 MMP24 MTCH2 PPA2 ZNF638
Whole body fat-free mass 4.95 14 12 36.4 0.19 5.0e-01 ABCB9 AKTIP DCAF16 FOXO3 GGNBP2 MGAT3 MMP24 NEGR1 PEF1 PPA2 SULT1A1 SYPL2 UBA7 ZNF638
Leg fat-free mass (right) 4.53 14 11 33.3 0.17 5.5e-01 ABCB9 AKTIP DCAF16 FOXO3 GGNBP2 MGAT3 MMP24 NEGR1 PEF1 PPA2 SULT1A1 SYPL2 UBA7 ZNF638
Arm fat percentage (left) 3.97 10 6 18.2 -0.67 3.3e-02 AFF3 CHST10 DCAF16 FOXO3 GGNBP2 MTCH2 NEGR1 RARB SULT1A1 UBA7
Average weekly red wine intake 2.50 1 0 0.0 0.00 1.0e+00 ABCB9
Handedness (chirality/laterality): Left-handed 2.01 2 1 3.0 0.00 1.0e+00 MAPT SULT1A1
Mood swings 2.22 3 2 6.1 0.00 1.0e+00 MAPT TMEM110 UBA7
Loneliness, isolation 2.22 1 1 3.0 0.00 1.0e+00 MTCH2
Long-standing illness, disability or infirmity 1.99 3 0 0.0 0.00 1.0e+00 NEGR1 RARB RP11-73M18.8
Ever had bowel cancer screening 1.27 1 0 0.0 0.00 1.0e+00 UBA7
Diabetes diagnosed by doctor 2.10 2 0 0.0 0.00 1.0e+00 AKTIP UBA7
Qualifications: nursing, teaching 4.39 4 2 6.1 0.97 3.4e-02 ABCB9 NEGR1 ST3GAL3 UBA7
Mouth/teeth dental problems: Mouth ulcers 1.79 1 1 3.0 0.00 1.0e+00 MAPT
Medication for cholesterol 2.18 2 0 0.0 0.00 1.0e+00 AKTIP MAPT
Asthma (self-reported) 1.35 1 0 0.0 0.00 1.0e+00 AFF3
Smoking status: Current 2.30 2 1 3.0 0.00 1.0e+00 MTCH2 ST3GAL3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.42 3 2 6.1 0.00 1.0e+00 MAPT PPA2 RARB
Whole body water mass 4.95 14 12 36.4 0.19 4.9e-01 ABCB9 AKTIP DCAF16 FOXO3 GGNBP2 MGAT3 MMP24 NEGR1 PEF1 PPA2 SULT1A1 SYPL2 UBA7 ZNF638
Leg predicted mass (right) 4.53 14 11 33.3 0.17 5.5e-01 ABCB9 AKTIP DCAF16 FOXO3 GGNBP2 MGAT3 MMP24 NEGR1 PEF1 PPA2 SULT1A1 SYPL2 UBA7 ZNF638
Arm fat mass (left) 3.87 9 7 21.2 -0.54 1.3e-01 AFF3 CHST10 FOXO3 GGNBP2 MMP24 MTCH2 NEGR1 SULT1A1 UBA7
Number of self-reported non-cancer illnesses 2.23 2 1 3.0 0.00 1.0e+00 FBXO41 NEGR1
Average weekly champagne plus white wine intake 2.37 2 0 0.0 0.00 1.0e+00 ITGAD MAPT
Miserableness 2.34 3 1 3.0 0.00 1.0e+00 MTCH2 TANK UBA7
Financial situation satisfaction 1.99 1 0 0.0 0.00 1.0e+00 UBA7
Commuting to job workplace: Public transport 2.87 2 0 0.0 0.00 1.0e+00 CHST10 NEGR1
Medication: Blood pressure 1.46 1 0 0.0 0.00 1.0e+00 MAPT
High cholesterol (Self-reported) 1.23 1 0 0.0 0.00 1.0e+00 DCAF16
Medication: Paracetamol 2.71 2 1 3.0 0.00 1.0e+00 MAPT SULT1A1
Ever smoked 2.40 2 0 0.0 0.00 1.0e+00 NUCB2 PPA2
Basal metabolic rate 4.78 14 12 36.4 0.16 5.7e-01 ABCB9 AKTIP DCAF16 FOXO3 GGNBP2 MGAT3 MMP24 NEGR1 PEF1 PPA2 SULT1A1 SYPL2 UBA7 ZNF638
Leg fat percentage (left) 4.17 10 8 24.2 -0.69 2.9e-02 AFF3 BNIP3 CHST10 DCAF16 FOXO3 GGNBP2 MTCH2 NEGR1 SULT1A1 UBA7
Arm fat-free mass (left) 4.73 13 11 33.3 0.16 5.8e-01 ABCB9 AKTIP DCAF16 FOXO3 GGNBP2 MGAT3 MMP24 NEGR1 PEF1 PPA2 SULT1A1 UBA7 ZNF638
Number of operations (self-reported) 2.25 3 1 3.0 0.00 1.0e+00 NEGR1 PPA2 TANK
Average weekly beer plus cider intake 2.82 2 1 3.0 0.00 1.0e+00 NEGR1 UBA7
Irritability 1.84 1 0 0.0 0.00 1.0e+00 MAPT
Diastolic blood pressure, automated reading 1.85 4 3 9.1 -0.98 2.0e-02 ABCB9 DCAF16 FBXO41 UBA7
Ever depressed for a whole week 2.22 1 0 0.0 0.00 1.0e+00 RP11-73M18.8
Unable to work because of sickness or disability 1.62 1 0 0.0 0.00 1.0e+00 FBXO41
Myopia 2.50 1 0 0.0 0.00 1.0e+00 MTCH2
Vascular/heart problems diagnosed by doctor 1.66 4 1 3.0 0.55 4.5e-01 AKTIP DCAF16 FBXO41 NEGR1
Cholesterol lowering medication 1.50 1 0 0.0 0.00 1.0e+00 DCAF16
Pain experienced in last month 1.76 1 0 0.0 0.00 1.0e+00 UBA7
Alcohol drinker status: Previous 1.46 1 0 0.0 0.00 1.0e+00 RP11-73M18.8
Pack years of smoking 1.98 1 0 0.0 0.00 1.0e+00 BNIP3
Impedance of whole body 2.39 13 7 21.2 -0.15 6.2e-01 AFF3 AKTIP FOXO3 GGNBP2 MAPT MMP24 NEGR1 NUCB2 PEF1 PFDN1 PPA2 SYPL2 UBA7
Leg fat mass (left) 4.00 10 7 21.2 -0.49 1.5e-01 AFF3 CHST10 FOXO3 GGNBP2 MMP24 MTCH2 NEGR1 PEF1 SULT1A1 UBA7
Arm predicted mass (left) 4.80 14 11 33.3 0.16 5.7e-01 ABCB9 AKTIP DCAF16 FOXO3 GGNBP2 MGAT3 MMP24 NEGR1 PEF1 PPA2 SULT1A1 SYPL2 UBA7 ZNF638

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 13 0.372 2.11
GTEx Adipose Visceral Omentum 7 0.344 2.20
GTEx Adrenal Gland 4 0.275 2.01
GTEx Artery Aorta 17 0.571 2.19
GTEx Artery Coronary 5 0.423 2.07
GTEx Artery Tibial 19 0.505 2.12
GTEx Brain Caudate basal ganglia 4 0.435 2.14
GTEx Brain Cerebellar Hemisphere 7 0.470 2.24
GTEx Brain Cerebellum 9 0.454 2.13
GTEx Brain Cortex 9 0.870 2.37
GTEx Brain Frontal Cortex BA9 3 0.325 2.24
GTEx Brain Hippocampus 1 0.191 2.24
GTEx Brain Hypothalamus 2 0.339 2.13
GTEx Brain Nucleus accumbens basal ganglia 5 0.578 2.23
GTEx Brain Putamen basal ganglia 2 0.321 2.29
GTEx Breast Mammary Tissue 11 0.557 2.28
GTEx Breast Mammary Tissue (Male) 3 0.251 2.11
GTEx Breast Mammary Tissue (Female) 8 0.487 2.18
GTEx Cells EBV-transformed lymphocytes 5 0.351 2.23
GTEx Cells Transformed fibroblasts 12 0.286 2.12
GTEx Colon Sigmoid 7 0.479 2.26
GTEx Colon Transverse 8 0.388 2.29
GTEx Esophagus Gastroesophageal Junction 9 0.623 2.38
GTEx Esophagus Mucosa 12 0.361 2.22
GTEx Esophagus Muscularis 15 0.464 2.24
GTEx Heart Atrial Appendage 8 0.507 2.32
GTEx Heart Left Ventricle 7 0.458 2.29
GTEx Liver 2 0.279 2.19
GTEx Lung 16 0.557 2.17
GTEx Muscle Skeletal 15 0.519 2.21
GTEx Nerve Tibial 14 0.324 2.11
GTEx Ovary 5 0.551 2.48
GTEx Pancreas 6 0.368 2.19
GTEx Pituitary 3 0.269 2.13
GTEx Prostate 4 0.479 2.13
GTEx Skin Not Sun Exposed Suprapubic 10 0.407 2.24
GTEx Skin Sun Exposed Lower leg 14 0.385 2.21
GTEx Small Intestine Terminal Ileum 2 0.434 2.35
GTEx Spleen 6 0.425 2.26
GTEx Stomach 7 0.481 2.28
GTEx Testis 8 0.254 2.07
GTEx Thyroid 8 0.200 2.10
GTEx Uterus 1 0.176 2.17
GTEx Vagina 6 0.945 2.49
GTEx Whole Blood 8 0.401 2.13
METSIM Adipose 16 0.347 1.93
NTR Blood 7 0.291 2.01
ROSMAP Brain Pre-frontal Cortex 17 0.387 2.14
YFS Blood 10 0.217 1.90
CommonMind Brain Pre-frontal Cortex 11 0.205 1.97
TCGA Breast Tumor 1 0.130 2.06
TCGA Breast Normal 6 0.143 1.80
TCGA Ovarian Tumor 6 0.205 1.93
TCGA Prostate Tumor 11 0.318 1.95