Hub : Traits :

Type 2 Diabetes (T2D)

281 significantly associated models · 91 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 39182130 40737589 6 1 1.7e-11 3.3e-10 7.9e-03 82 RP11-69E11.4
2 1 119761038 120687115 2 1 4.0e-08 2.8e-08 1.0e+00 100 RP5-1042I8.7
3 1 213759712 215206914 1 1 3.0e-09 2.0e-12 2.9e-05 65 SMYD2
4 1 235684842 237144310 1 1 1.6e-07 1.6e-07 1.0e+00 100 ERO1LB
5 2 26655745 28607344 8 1 1.0e-11 3.4e-15 6.9e-05 74 AC074117.10
6 2 42753863 44157441 2 1 3.9e-15 1.0e-16 6.8e-03 89 AC010883.5
7 2 164657815 166170073 1 1 2.2e-07 5.8e-15 9.9e-10 39 GRB14
8 3 49030828 50833360 5 1 9.4e-10 2.4e-09 4.1e-02 88 RBM6
9 3 137189600 138819532 2 1 1.2e-07 9.7e-08 2.5e-01 95 MRAS
10 4 5575751 7002344 1 1 7.9e-16 9.6e-19 1.5e-05 76 WFS1
11 5 101726770 103238413 2 1 1.9e-07 8.7e-07 3.5e-01 96 GIN1
12 6 6582123 8009760 1 1 7.7e-13 2.2e-07 3.0e-03 67 SSR1
13 6 19703618 21930988 2 2 4.6e-11 1.0e-31 1.5e-20 37 CDKAL1 E2F3
14 6 126271503 127664661 1 1 3.4e-07 2.5e-10 2.5e-06 45 PRELID1P1
15 7 6502367 7988091 1 1 9.3e-08 6.9e-07 8.7e-01 100 C1GALT1
16 7 73624615 74494207 1 1 2.0e-07 4.3e-07 1.0e+00 100 PMS2P5
17 7 102334106 103489729 1 1 1.1e-08 1.1e-06 9.9e-01 100 NAPEPLD
18 8 40811597 42450441 1 2 1.4e-14 1.7e-15 1.0e+00 100 ANK1
19 8 95199215 96607028 1 1 1.5e-07 2.7e-09 5.3e-03 78 CCNE2
20 8 145018354 146293414 4 1 2.7e-08 3.3e-07 2.0e-01 94 ZNF34
21 10 11477584 13569805 3 1 2.3e-13 6.6e-14 1.0e+00 100 CAMK1D
22 10 80443273 81901722 1 1 5.4e-12 3.7e-15 1.6e-05 70 ZCCHC24
23 10 92860281 95151622 6 1 4.4e-28 8.0e-27 1.8e-03 92 EIF2S2P3
24 10 101291593 102725979 2 1 1.5e-08 5.8e-08 7.2e-01 100 RP11-316M21.6
25 10 113511441 115622375 2 1 2.0e-59 1.7e-204 1.4e-155 24 TCF7L2
26 11 2213166 3597515 1 1 1.2e-15 3.0e-19 2.5e-14 28 CDKN1C
27 11 16691743 18106069 3 1 1.5e-11 1.3e-12 4.7e-03 84 RP1-239B22.5
28 11 64615450 66333072 4 2 6.8e-10 1.7e-08 4.4e-01 98 CTSW SSSCA1-AS1
29 11 71339667 73198494 3 2 3.0e-08 2.6e-16 1.2e-07 58 ARAP1 CLPB
30 12 122942185 124424636 1 1 3.4e-08 1.0e-04 7.3e-01 99 MPHOSPH9
31 15 41119185 42800767 2 1 1.9e-07 2.6e-07 1.0e+00 100 RPAP1
32 15 74951357 78474476 7 2 2.5e-09 1.9e-11 3.0e-03 80 HMG20A SNUPN
33 15 89680384 91152345 1 1 4.1e-10 3.7e-09 7.0e-01 100 AP3S2
34 16 52772129 54235440 2 1 3.0e-09 3.1e-29 3.5e-29 0 RBL2
35 16 69323837 70794031 1 1 2.2e-07 6.2e-10 3.9e-05 56 PDXDC2
36 16 74635632 76159151 1 1 1.3e-07 3.4e-12 1.7e-07 44 CFDP1
37 17 3208350 4863410 2 1 1.5e-07 1.4e-08 2.7e-02 85 ANKFY1
38 17 60858059 62259376 1 1 2.0e-07 1.7e-07 1.0e+00 100 ACE
39 19 12352086 13750618 1 1 3.9e-07 8.8e-07 2.8e-01 95 CALR
40 19 45313715 46846078 2 2 9.5e-10 5.7e-13 2.1e-07 48 EML2 PPM1N
41 20 31701333 33116483 1 1 3.9e-09 8.1e-09 1.0e+00 100 CHMP4B

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.63 1 1 3.0 0.00 1.0e+00 ACE
Crohns Disease (2017) 2.32 4 3 9.1 0.93 7.3e-02 AC010883.5 AC074117.10 PMS2P5 RBM6
Irritable Bowel Disease (IBD) 2.10 4 3 9.1 0.78 2.2e-01 AC010883.5 AC074117.10 PMS2P5 RBM6
Ulcerative Colitis (UC) 1.61 1 0 0.0 0.00 1.0e+00 RBM6
Verbal and Numeric Reasoning (VNR) 2.06 3 2 6.1 0.00 1.0e+00 GIN1 RBL2 RBM6
Breast Cancer 2.37 5 3 9.1 -0.76 1.3e-01 CALR CDKAL1 PMS2P5 SNUPN TCF7L2
Age at First Birth 1.94 1 1 3.0 0.00 1.0e+00 RBM6
Coronary Artery Disease (CAD) 2.15 1 0 0.0 0.00 1.0e+00 MRAS
Crohns Disease (2012) 1.88 1 0 0.0 0.00 1.0e+00 RBM6
Fasting Glucose 3.79 3 1 3.0 0.00 1.0e+00 AC074117.10 CLPB E2F3
HDL Cholesterol 2.50 4 2 6.1 -0.99 1.2e-02 CTSW GRB14 RBM6 RP11-69E11.4
Rheumatoid Arthritis 1.01 1 0 0.0 0.00 1.0e+00 GIN1
Triglycerides 6.76 2 2 6.1 0.00 1.0e+00 AC074117.10 GRB14
Type 2 Diabetes (T2D) 8.21 7 3 9.1 0.96 4.6e-04 ANK1 ARAP1 CCNE2 EIF2S2P3 SSR1 TCF7L2 WFS1
Ulcerative Colitis 1.47 1 0 0.0 0.00 1.0e+00 RBM6
Blood Eosinophil Count 1.13 7 5 15.2 -0.01 9.7e-01 AC010883.5 CCNE2 CTSW EIF2S2P3 MPHOSPH9 RBM6 SSSCA1-AS1
Blood Platelet Count 2.88 16 12 36.4 -0.22 4.2e-01 AC010883.5 AC074117.10 ANKFY1 AP3S2 CCNE2 CDKAL1 CDKN1C CTSW EIF2S2P3 EML2 MPHOSPH9 PPM1N RP11-69E11.4 RP1-239B22.5 SNUPN SSSCA1-AS1
Blood Red Count 1.43 9 7 21.2 0.77 1.6e-02 CALR CCNE2 GIN1 GRB14 HMG20A PPM1N RBM6 RPAP1 SNUPN
Blood White Count 1.35 7 2 6.1 0.30 5.1e-01 AC074117.10 EML2 GIN1 HMG20A RBM6 RP11-69E11.4 SNUPN
Heel T-Score 1.65 12 5 15.2 0.46 1.3e-01 AC010883.5 ANKFY1 CTSW MPHOSPH9 MRAS PMS2P5 RBM6 RP11-316M21.6 RP11-69E11.4 SMYD2 SSR1 SSSCA1-AS1
BMI 2.57 14 5 15.2 0.33 2.5e-01 ANKFY1 CTSW EML2 GIN1 GRB14 HMG20A PDXDC2 PMS2P5 PPM1N RBM6 RP11-69E11.4 RP1-239B22.5 TCF7L2 ZCCHC24
Height 1.44 19 13 39.4 -0.36 1.3e-01 AC010883.5 AC074117.10 ACE AP3S2 ARAP1 CALR CFDP1 CTSW GIN1 HMG20A MPHOSPH9 MRAS PDXDC2 PRELID1P1 RBL2 RP11-316M21.6 RP1-239B22.5 SNUPN SSR1
Waist Hip Ratio (WHR) 3.40 17 11 33.3 0.65 4.4e-03 AC010883.5 ANKFY1 CDKAL1 CTSW EIF2S2P3 EML2 GIN1 GRB14 MPHOSPH9 MRAS PRELID1P1 RBL2 RP1-239B22.5 RPAP1 SNUPN TCF7L2 ZCCHC24
Systolic Blood Pressure 2.53 12 5 15.2 0.52 8.5e-02 AC074117.10 C1GALT1 CAMK1D CCNE2 CTSW GRB14 MRAS PRELID1P1 RBM6 RP1-239B22.5 SSSCA1-AS1 TCF7L2
Smoking Status 0.89 1 0 0.0 0.00 1.0e+00 CTSW
Allergy or Eczema 1.24 2 0 0.0 0.00 1.0e+00 AC010883.5 AC074117.10
Cardiovascular Disease 3.83 13 8 24.2 0.53 6.0e-02 AC074117.10 ACE C1GALT1 CCNE2 CFDP1 CTSW MPHOSPH9 MRAS PDXDC2 PMS2P5 PRELID1P1 RP1-239B22.5 ZNF34
Hypothyroidism (self reported) 0.95 2 0 0.0 0.00 1.0e+00 AC010883.5 GIN1
Respiratory disease 1.04 2 0 0.0 0.00 1.0e+00 EIF2S2P3 RBM6
Lung FEV1/FVC ratio 3.20 11 8 24.2 -0.33 3.3e-01 AC010883.5 ANKFY1 ARAP1 C1GALT1 CAMK1D CFDP1 CLPB HMG20A PPM1N RP11-69E11.4 RPAP1
Lung FVC 1.71 9 5 15.2 -0.81 8.1e-03 C1GALT1 CAMK1D CHMP4B CLPB EML2 MRAS RBM6 SNUPN ZCCHC24
Neuroticism 1.27 1 0 0.0 0.00 1.0e+00 RBM6
Chronotype (morning person) 1.85 3 2 6.1 0.00 1.0e+00 MRAS NAPEPLD PPM1N
Hair Pigment 0.80 11 7 21.2 -0.12 7.2e-01 AC010883.5 AC074117.10 CDKAL1 CHMP4B CTSW E2F3 MPHOSPH9 MRAS NAPEPLD RP11-69E11.4 ZCCHC24
Tanning 1.17 4 3 9.1 0.68 3.2e-01 AC074117.10 CHMP4B RP11-316M21.6 RP5-1042I8.7
Hand grip strength (left) 1.10 1 0 0.0 0.00 1.0e+00 PDXDC2
Number of treatments/medications taken 3.07 4 1 3.0 -0.50 5.0e-01 AC074117.10 C1GALT1 CTSW RBM6
Systolic blood pressure, automated reading 2.02 6 4 12.1 -0.65 1.6e-01 CAMK1D CTSW PDXDC2 PMS2P5 PRELID1P1 RP1-239B22.5
Eye problems/disorders: Diabetes related eye disease 3.63 1 0 0.0 0.00 1.0e+00 TCF7L2
Medication: Co-codamol 1.29 1 0 0.0 0.00 1.0e+00 RBM6
Medication: Metformin 13.52 24 7 21.2 -0.99 8.1e-21 AC010883.5 AC074117.10 ANK1 AP3S2 ARAP1 CALR CAMK1D EIF2S2P3 ERO1LB MPHOSPH9 MRAS PDXDC2 PMS2P5 PPM1N RBL2 RBM6 RP11-69E11.4 RP1-239B22.5 RPAP1 SNUPN SSSCA1-AS1 TCF7L2 WFS1 ZCCHC24
Diabetes (father) 8.43 9 5 15.2 -1.00 4.3e-09 AC010883.5 ANK1 AP3S2 CDKAL1 E2F3 EIF2S2P3 GIN1 SSR1 TCF7L2
Diabetes (mother) 8.35 10 4 12.1 -0.99 2.4e-08 AC010883.5 ANK1 ARAP1 CALR CAMK1D CDKAL1 EIF2S2P3 SSSCA1-AS1 TCF7L2 WFS1
Pack years adult smoking proportion 1.41 2 0 0.0 0.00 1.0e+00 PDXDC2 PMS2P5
Impedance of leg (right) 1.84 11 6 18.2 0.49 1.3e-01 AC010883.5 AC074117.10 CTSW EML2 GIN1 PDXDC2 PMS2P5 RBL2 RBM6 RP11-69E11.4 RP1-239B22.5
Leg fat-free mass (left) 1.76 9 4 12.1 -0.33 3.9e-01 AC074117.10 ARAP1 CTSW MPHOSPH9 PRELID1P1 RBL2 RBM6 RP11-69E11.4 SNUPN
Trunk fat percentage 2.18 6 3 9.1 -0.29 5.7e-01 ANKFY1 CTSW GRB14 PDXDC2 RBM6 ZCCHC24
Hand grip strength (right) 1.19 1 0 0.0 0.00 1.0e+00 SNUPN
Maternal smoking around birth 1.43 1 0 0.0 0.00 1.0e+00 RBM6
Fed-up feelings 1.61 3 0 0.0 0.00 1.0e+00 AC010883.5 MPHOSPH9 RBM6
Relative age voice broke 1.04 1 0 0.0 0.00 1.0e+00 PDXDC2
Taking other prescription medications 2.14 2 1 3.0 0.00 1.0e+00 PMS2P5 RBM6
Age when periods started (menarche) 2.25 5 3 9.1 0.60 2.9e-01 CTSW PDXDC2 PMS2P5 RP11-316M21.6 SSSCA1-AS1
Heel bone mineral density (BMD) T-score, automated (left) 1.53 3 1 3.0 0.00 1.0e+00 CTSW RBM6 SSSCA1-AS1
Qualifications: CSEs or equivalent 1.50 1 0 0.0 0.00 1.0e+00 RBM6
High blood pressure 3.20 9 5 15.2 -0.57 1.1e-01 ACE C1GALT1 CCNE2 CTSW MRAS PDXDC2 PMS2P5 PRELID1P1 RP1-239B22.5
Hayfever, allergic rhinitis or eczema 1.20 2 0 0.0 0.00 1.0e+00 AC010883.5 AC074117.10
Medication: Atenolol 1.52 1 0 0.0 0.00 1.0e+00 PRELID1P1
Sitting height 1.60 9 7 21.2 0.15 7.1e-01 AC074117.10 MPHOSPH9 PDXDC2 PRELID1P1 RBL2 RP11-69E11.4 SNUPN SSR1 ZCCHC24
High blood pressure (mother) 1.76 1 0 0.0 0.00 1.0e+00 MRAS
Body mass index (BMI) 2.73 7 4 12.1 0.02 9.6e-01 CTSW GRB14 HMG20A PDXDC2 PMS2P5 RBM6 TCF7L2
Impedance of leg (left) 1.97 10 6 18.2 0.52 1.3e-01 AC010883.5 AC074117.10 CTSW EML2 GIN1 PDXDC2 RBL2 RBM6 RP11-69E11.4 RP1-239B22.5
Leg predicted mass (left) 1.76 9 4 12.1 -0.33 3.9e-01 AC074117.10 ARAP1 CTSW MPHOSPH9 PRELID1P1 RBL2 RBM6 RP11-69E11.4 SNUPN
Trunk fat mass 2.06 7 3 9.1 -0.07 8.8e-01 ANKFY1 CTSW GRB14 PDXDC2 RBM6 RP11-69E11.4 TCF7L2
Waist circumference 2.45 8 4 12.1 -0.32 4.3e-01 ANKFY1 CTSW EML2 PDXDC2 RBM6 RP11-69E11.4 TCF7L2 ZCCHC24
Past tobacco smoking 1.31 1 0 0.0 0.00 1.0e+00 CTSW
Alcohol usually taken with meals 1.67 1 0 0.0 0.00 1.0e+00 MRAS
Nervous feelings 1.27 1 0 0.0 0.00 1.0e+00 EML2
Frequency of tenseness / restlessness in last 2 weeks 1.55 1 0 0.0 0.00 1.0e+00 MPHOSPH9
Had menopause 2.00 1 1 3.0 0.00 1.0e+00 AC074117.10
Forced vital capacity (FVC) 1.63 9 2 6.1 0.75 2.0e-02 CAMK1D EML2 HMG20A MRAS PDXDC2 SMYD2 SNUPN SSR1 ZCCHC24
Heel bone mineral density (BMD) T-score, automated (right) 1.52 3 0 0.0 0.00 1.0e+00 CTSW RBM6 SSSCA1-AS1
Qualifications: None of the above 1.68 3 2 6.1 0.00 1.0e+00 MPHOSPH9 RBL2 RBM6
Mouth/teeth dental problems 1.86 2 0 0.0 0.00 1.0e+00 PMS2P5 RP1-239B22.5
Allergy 1.00 1 0 0.0 0.00 1.0e+00 AC010883.5
Diabetes (self-reported) 17.02 37 18 54.5 -0.99 6.7e-32 AC010883.5 AC074117.10 ANK1 AP3S2 ARAP1 C1GALT1 CALR CAMK1D CCNE2 CDKN1C CFDP1 CHMP4B CLPB E2F3 EIF2S2P3 ERO1LB HMG20A MPHOSPH9 MRAS NAPEPLD PDXDC2 PMS2P5 PPM1N RBL2 RBM6 RP11-69E11.4 RP1-239B22.5 RP5-1042I8.7 RPAP1 SMYD2 SNUPN SSR1 SSSCA1-AS1 TCF7L2 WFS1 ZCCHC24 ZNF34
Medication: Ramipril 2.82 3 0 0.0 0.00 1.0e+00 ANKFY1 CTSW MRAS
Medication: Simvastatin 3.06 3 0 0.0 0.00 1.0e+00 AC074117.10 CTSW TCF7L2
Fluid intelligence score 2.28 3 1 3.0 0.00 1.0e+00 RBL2 RBM6 RP1-239B22.5
Illnesses of siblings 2.20 1 0 0.0 0.00 1.0e+00 PRELID1P1
Neuroticism score 1.47 3 0 0.0 0.00 1.0e+00 AC010883.5 MPHOSPH9 RBM6
Weight 1.98 11 3 9.1 -0.29 4.0e-01 AC074117.10 ANKFY1 CTSW GRB14 NAPEPLD PDXDC2 PRELID1P1 RBL2 RBM6 RP11-69E11.4 TCF7L2
Impedance of arm (right) 2.06 9 5 15.2 0.33 3.9e-01 AC074117.10 CTSW E2F3 GRB14 HMG20A RBM6 RP1-239B22.5 SSSCA1-AS1 TCF7L2
Arm fat percentage (right) 2.48 6 4 12.1 0.16 7.7e-01 CTSW GRB14 PDXDC2 RBM6 RP11-69E11.4 TCF7L2
Trunk fat-free mass 1.77 9 6 18.2 -0.36 3.4e-01 AC074117.10 MPHOSPH9 NAPEPLD PRELID1P1 RBL2 RBM6 RP11-69E11.4 SNUPN SSR1
Hip circumference 2.05 6 4 12.1 0.38 4.6e-01 GRB14 PDXDC2 RBL2 RBM6 RP11-69E11.4 TCF7L2
Alcohol intake versus 10 years previously 2.38 3 2 6.1 0.00 1.0e+00 AC074117.10 RBM6 RP11-69E11.4
Father's age at death 1.70 1 0 0.0 0.00 1.0e+00 MPHOSPH9
Worrier / anxious feelings 1.39 2 0 0.0 0.00 1.0e+00 GIN1 PDXDC2
Frequency of tiredness / lethargy in last 2 weeks 1.33 1 0 0.0 0.00 1.0e+00 MPHOSPH9
Number of live births 1.30 1 0 0.0 0.00 1.0e+00 RBM6
Forced expiratory volume in 1-second (FEV1) 1.83 6 1 3.0 0.99 7.4e-05 C1GALT1 CAMK1D EML2 PDXDC2 SNUPN ZCCHC24
Pulse rate 1.77 2 0 0.0 0.00 1.0e+00 AC074117.10 RBL2
Qualifications: A levels/AS levels or equivalent 1.81 2 1 3.0 0.00 1.0e+00 MPHOSPH9 RBM6
Mouth/teeth dental problems: Dentures 2.14 3 0 0.0 0.00 1.0e+00 CLPB PMS2P5 RBM6
Asthma 1.11 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Medication: Cholesterol lowering 3.52 6 1 3.0 -0.48 3.4e-01 AC074117.10 C1GALT1 CHMP4B MRAS PDXDC2 TCF7L2
Forced expiratory volume in 1-second (FEV1), Best measure 1.91 5 1 3.0 0.99 7.8e-04 C1GALT1 CAMK1D PDXDC2 SNUPN ZCCHC24
Impedance of arm (left) 2.10 10 7 21.2 0.39 2.7e-01 AC010883.5 AC074117.10 CTSW E2F3 GRB14 HMG20A RBM6 RP1-239B22.5 SSSCA1-AS1 TCF7L2
Arm fat mass (right) 2.37 6 5 15.2 0.09 8.6e-01 CTSW GRB14 PDXDC2 RBM6 RP11-69E11.4 TCF7L2
Trunk predicted mass 1.77 9 6 18.2 -0.36 3.4e-01 AC074117.10 MPHOSPH9 NAPEPLD PRELID1P1 RBL2 RBM6 RP11-69E11.4 SNUPN SSR1
Standing height 1.40 11 8 24.2 0.19 5.7e-01 AC074117.10 CALR GIN1 MPHOSPH9 PDXDC2 PRELID1P1 RBL2 RP11-316M21.6 RP1-239B22.5 SNUPN SSR1
Exposure to tobacco smoke at home 0.98 1 0 0.0 0.00 1.0e+00 RBM6
Hair/balding pattern: Pattern 4 1.73 3 1 3.0 0.00 1.0e+00 AC010883.5 CDKAL1 PRELID1P1
Birth weight of first child 1.62 1 0 0.0 0.00 1.0e+00 SSR1
Peak expiratory flow (PEF) 1.78 4 2 6.1 1.00 2.4e-03 AC010883.5 C1GALT1 CAMK1D SNUPN
Ever highly irritable/argumentative for 2 days 1.54 2 0 0.0 0.00 1.0e+00 RBM6 SNUPN
Qualifications: O levels/GCSEs or equivalent 1.21 1 0 0.0 0.00 1.0e+00 MPHOSPH9
Headache pain in last month 1.55 1 0 0.0 0.00 1.0e+00 RP11-316M21.6
Medication for cholesterol, blood pressure or diabetes 4.09 9 1 3.0 0.99 5.6e-07 ACE C1GALT1 CAMK1D CHMP4B CTSW MRAS PDXDC2 PPM1N RBM6
Gout (self-reported) 2.66 1 1 3.0 0.00 1.0e+00 AC074117.10
Medication: Amlodipine 1.66 1 0 0.0 0.00 1.0e+00 PRELID1P1
Medication: Ventolin 100micrograms inhaler 1.20 1 0 0.0 0.00 1.0e+00 RBM6
Birth weight 3.10 6 2 6.1 0.48 2.8e-01 ANK1 CCNE2 CDKAL1 E2F3 EIF2S2P3 SMYD2
Chronic bronchitis/emphysema (mother) 1.32 1 0 0.0 0.00 1.0e+00 RBM6
High blood pressure (siblings) 2.15 1 1 3.0 0.00 1.0e+00 PRELID1P1
Forced vital capacity (FVC), Best measure 1.69 8 3 9.1 0.69 5.8e-02 CAMK1D EML2 HMG20A MRAS PDXDC2 SNUPN SSR1 ZCCHC24
Body fat percentage 2.48 7 3 9.1 0.24 6.1e-01 ANKFY1 CTSW GRB14 PDXDC2 RBM6 TCF7L2 ZCCHC24
Leg fat percentage (right) 2.80 9 4 12.1 -0.07 8.6e-01 ANKFY1 CTSW GRB14 HMG20A PDXDC2 RBM6 SNUPN TCF7L2 ZCCHC24
Arm fat-free mass (right) 1.89 8 5 15.2 -0.32 4.4e-01 AC074117.10 CTSW MPHOSPH9 PRELID1P1 RBL2 RBM6 SNUPN SSR1
Exposure to tobacco smoke outside home 1.29 1 0 0.0 0.00 1.0e+00 RBM6
Comparative body size at age 10 1.19 3 0 0.0 0.00 1.0e+00 AC074117.10 MRAS PDXDC2
Number of full brothers 1.55 1 0 0.0 0.00 1.0e+00 HMG20A
Wheeze or whistling in the chest in last year 1.59 1 1 3.0 0.00 1.0e+00 RBM6
Age at first live birth 1.78 1 1 3.0 0.00 1.0e+00 RBM6
Health satisfaction 1.37 1 0 0.0 0.00 1.0e+00 RBM6
Qualifications: College or University degree 1.86 3 1 3.0 0.00 1.0e+00 MPHOSPH9 RBL2 RBM6
Medication: Blood pressure 3.17 6 0 0.0 -0.73 1.0e-01 ACE C1GALT1 CAMK1D CTSW PDXDC2 PRELID1P1
Medication: Allopurinol 2.36 1 1 3.0 0.00 1.0e+00 AC074117.10
Medication: Seretide 50 evohaler 1.19 1 0 0.0 0.00 1.0e+00 RBM6
Whole body fat mass 2.33 6 4 12.1 0.16 7.6e-01 ANKFY1 CTSW GRB14 PDXDC2 RBM6 TCF7L2
Leg fat mass (right) 2.60 9 5 15.2 -0.19 6.2e-01 ANKFY1 CTSW GRB14 HMG20A NAPEPLD PDXDC2 RBM6 TCF7L2 ZCCHC24
Arm predicted mass (right) 1.83 8 4 12.1 -0.50 2.0e-01 AC074117.10 CTSW NAPEPLD PRELID1P1 RBL2 RBM6 SNUPN SSR1
Pulse rate, automated reading 2.80 7 6 18.2 -0.37 4.2e-01 AC074117.10 PDXDC2 RBL2 RBM6 RP11-69E11.4 SSSCA1-AS1 WFS1
Alcohol intake frequency. 2.76 5 2 6.1 -0.21 7.3e-01 AC074117.10 HMG20A PDXDC2 PMS2P5 RBM6
Comparative height size at age 10 1.51 6 6 18.2 0.08 8.8e-01 AC010883.5 AC074117.10 MPHOSPH9 PRELID1P1 RBL2 RP1-239B22.5
Overall health rating 2.74 4 2 6.1 -0.98 1.6e-02 CTSW PMS2P5 RBL2 RBM6
Age at last live birth 2.11 2 1 3.0 0.00 1.0e+00 EIF2S2P3 RBM6
Leg pain on walking 1.09 1 0 0.0 0.00 1.0e+00 RBM6
Qualifications: NVQ or HND or HNC or equivalent 1.28 1 0 0.0 0.00 1.0e+00 RBM6
Knee pain experienced in last month 1.37 1 0 0.0 0.00 1.0e+00 ZCCHC24
Hypertension (Self-reported) 3.24 9 5 15.2 -0.57 1.1e-01 ACE C1GALT1 CCNE2 CTSW MRAS PDXDC2 PMS2P5 PRELID1P1 RP1-239B22.5
Illnesses of father: Heart disease 1.47 1 0 0.0 0.00 1.0e+00 ZCCHC24
Illnesses of siblings: Diabetes 5.12 4 2 6.1 -0.97 2.9e-02 CAMK1D EIF2S2P3 PMS2P5 TCF7L2
Smoking status: Previous 1.38 1 0 0.0 0.00 1.0e+00 CTSW
Whole body fat-free mass 1.75 10 5 15.2 -0.42 2.3e-01 AC074117.10 CTSW MPHOSPH9 NAPEPLD PRELID1P1 RBL2 RBM6 RP11-69E11.4 SNUPN SSR1
Leg fat-free mass (right) 1.69 9 4 12.1 -0.30 4.3e-01 AC074117.10 ARAP1 CTSW MPHOSPH9 PRELID1P1 RBL2 RBM6 RP11-69E11.4 SNUPN
Arm fat percentage (left) 2.57 6 4 12.1 0.78 6.9e-02 CTSW GRB14 PDXDC2 PMS2P5 RBM6 TCF7L2
Mood swings 1.49 1 1 3.0 0.00 1.0e+00 RBM6
Long-standing illness, disability or infirmity 2.83 4 0 0.0 -0.99 9.0e-03 MRAS PMS2P5 RBM6 RP11-69E11.4
Ever had bowel cancer screening 1.14 1 0 0.0 0.00 1.0e+00 RBM6
Diabetes diagnosed by doctor 18.11 42 20 60.6 -0.99 5.3e-39 AC010883.5 AC074117.10 ACE ANK1 AP3S2 ARAP1 C1GALT1 CALR CAMK1D CCNE2 CDKAL1 CDKN1C CFDP1 CHMP4B CLPB CTSW E2F3 EIF2S2P3 ERO1LB GIN1 HMG20A MPHOSPH9 MRAS NAPEPLD PDXDC2 PMS2P5 PPM1N RBL2 RBM6 RP11-316M21.6 RP11-69E11.4 RP1-239B22.5 RP5-1042I8.7 RPAP1 SMYD2 SNUPN SSR1 SSSCA1-AS1 TCF7L2 WFS1 ZCCHC24 ZNF34
Qualifications: nursing, teaching 1.44 1 0 0.0 0.00 1.0e+00 RBM6
Medication for cholesterol 2.51 2 0 0.0 0.00 1.0e+00 AC074117.10 PRELID1P1
Asthma (self-reported) 1.07 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Medication: Gliclazide 6.96 4 1 3.0 -0.99 8.4e-03 CTSW MRAS TCF7L2 WFS1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.45 2 1 3.0 0.00 1.0e+00 ANKFY1 CAMK1D
Whole body water mass 1.77 10 6 18.2 -0.41 2.4e-01 AC074117.10 CTSW MPHOSPH9 NAPEPLD PRELID1P1 RBL2 RBM6 RP11-69E11.4 SNUPN SSR1
Leg predicted mass (right) 1.67 8 4 12.1 -0.35 4.0e-01 AC074117.10 CTSW MPHOSPH9 PRELID1P1 RBL2 RBM6 RP11-69E11.4 SNUPN
Arm fat mass (left) 2.34 7 4 12.1 -0.09 8.4e-01 ANKFY1 CTSW GRB14 PDXDC2 RBM6 RP11-69E11.4 TCF7L2
Number of self-reported non-cancer illnesses 2.57 4 0 0.0 -0.42 5.8e-01 AC074117.10 MPHOSPH9 PDXDC2 PMS2P5
Miserableness 1.71 2 1 3.0 0.00 1.0e+00 MPHOSPH9 RBM6
Mother's age at death 1.88 1 0 0.0 0.00 1.0e+00 SNUPN
Financial situation satisfaction 1.45 1 0 0.0 0.00 1.0e+00 RBM6
Medication: Blood pressure 2.64 5 1 3.0 -0.59 3.0e-01 C1GALT1 CTSW MRAS PRELID1P1 RP1-239B22.5
High cholesterol (Self-reported) 3.19 4 1 3.0 -0.03 9.7e-01 AC074117.10 C1GALT1 MPHOSPH9 PDXDC2
Medication: Bendroflumethiazide 1.74 1 0 0.0 0.00 1.0e+00 PRELID1P1
Medication: Atorvastatin 2.32 2 1 3.0 0.00 1.0e+00 AC074117.10 TCF7L2
Basal metabolic rate 1.77 10 4 12.1 -0.47 1.7e-01 AC074117.10 CTSW MPHOSPH9 NAPEPLD PRELID1P1 RBL2 RBM6 RP11-69E11.4 SNUPN SSR1
Leg fat percentage (left) 2.76 9 4 12.1 -0.07 8.6e-01 CTSW GRB14 HMG20A MPHOSPH9 PDXDC2 RBM6 SNUPN TCF7L2 ZCCHC24
Arm fat-free mass (left) 1.88 9 4 12.1 -0.44 2.3e-01 AC074117.10 CTSW MPHOSPH9 NAPEPLD PRELID1P1 RBL2 RBM6 SNUPN SSR1
Average weekly beer plus cider intake 1.11 1 1 3.0 0.00 1.0e+00 RBM6
Irritability 1.46 2 0 0.0 0.00 1.0e+00 AC010883.5 ANKFY1
Age started oral contraceptive pill 1.46 1 0 0.0 0.00 1.0e+00 RBM6
Diastolic blood pressure, automated reading 2.34 7 6 18.2 -0.78 4.0e-02 ANKFY1 C1GALT1 CTSW MPHOSPH9 PMS2P5 PRELID1P1 RBM6
Vascular/heart problems diagnosed by doctor 3.36 10 5 15.2 0.73 1.6e-02 ACE C1GALT1 CCNE2 CDKAL1 CTSW MRAS PDXDC2 PMS2P5 PPM1N PRELID1P1
Cholesterol lowering medication 2.81 2 1 3.0 0.00 1.0e+00 AC074117.10 TCF7L2
Pain experienced in last month 1.49 1 0 0.0 0.00 1.0e+00 RBM6
Pack years of smoking 1.44 2 0 0.0 0.00 1.0e+00 PDXDC2 PMS2P5
Impedance of whole body 2.00 14 5 15.2 0.24 4.2e-01 AC010883.5 AC074117.10 CTSW E2F3 EML2 GIN1 GRB14 HMG20A PDXDC2 PMS2P5 RBL2 RBM6 RP1-239B22.5 TCF7L2
Leg fat mass (left) 2.57 8 5 15.2 -0.07 8.6e-01 ANKFY1 CTSW GRB14 HMG20A PDXDC2 RBM6 TCF7L2 ZCCHC24
Arm predicted mass (left) 1.91 9 3 9.1 -0.43 2.5e-01 AC074117.10 CTSW MPHOSPH9 NAPEPLD PRELID1P1 RBL2 RBM6 SNUPN SSR1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 7 0.2005 1.92
GTEx Adipose Visceral Omentum 7 0.3436 1.97
GTEx Adrenal Gland 5 0.3432 1.86
GTEx Artery Aorta 8 0.2687 2.07
GTEx Artery Coronary 3 0.2534 1.76
GTEx Artery Tibial 8 0.2129 1.99
GTEx Brain Caudate basal ganglia 0 0.0000 1.77
GTEx Brain Cerebellar Hemisphere 5 0.3358 1.95
GTEx Brain Cerebellum 2 0.1009 2.00
GTEx Brain Cortex 2 0.1934 1.95
GTEx Brain Frontal Cortex BA9 2 0.2162 1.80
GTEx Brain Hippocampus 0 0.0000 1.80
GTEx Brain Hypothalamus 1 0.1692 1.61
GTEx Brain Nucleus accumbens basal ganglia 2 0.2309 1.76
GTEx Brain Putamen basal ganglia 0 0.0000 1.80
GTEx Breast Mammary Tissue 6 0.3038 1.92
GTEx Breast Mammary Tissue (Male) 2 0.1676 1.91
GTEx Breast Mammary Tissue (Female) 2 0.1216 1.89
GTEx Cells EBV-transformed lymphocytes 2 0.1407 1.91
GTEx Cells Transformed fibroblasts 11 0.2620 1.93
GTEx Colon Sigmoid 4 0.2734 1.79
GTEx Colon Transverse 6 0.2906 1.95
GTEx Esophagus Gastroesophageal Junction 7 0.4844 1.91
GTEx Esophagus Mucosa 10 0.3011 1.95
GTEx Esophagus Muscularis 9 0.2785 1.98
GTEx Heart Atrial Appendage 4 0.2532 2.00
GTEx Heart Left Ventricle 1 0.0653 1.92
GTEx Liver 2 0.2789 1.65
GTEx Lung 9 0.3133 2.00
GTEx Muscle Skeletal 6 0.2075 1.95
GTEx Nerve Tibial 12 0.2775 1.93
GTEx Ovary 3 0.3300 2.00
GTEx Pancreas 3 0.1837 1.95
GTEx Pituitary 3 0.2688 2.00
GTEx Prostate 2 0.2398 2.07
GTEx Skin Not Sun Exposed Suprapubic 8 0.3252 1.97
GTEx Skin Sun Exposed Lower leg 10 0.2750 1.92
GTEx Small Intestine Terminal Ileum 0 0.0000 1.72
GTEx Spleen 2 0.1417 1.82
GTEx Stomach 3 0.2062 1.89
GTEx Testis 7 0.2217 1.91
GTEx Thyroid 14 0.3503 2.09
GTEx Uterus 1 0.1764 1.70
GTEx Vagina 3 0.4724 1.76
GTEx Whole Blood 3 0.1508 1.99
METSIM Adipose 11 0.2389 1.86
NTR Blood 10 0.4163 1.85
ROSMAP Brain Pre-frontal Cortex 7 0.1595 1.84
YFS Blood 13 0.2817 1.83
CommonMind Brain Pre-frontal Cortex 16 0.2976 1.92
TCGA Breast Tumor 3 0.3916 1.87
TCGA Breast Normal 8 0.1902 1.69
TCGA Ovarian Tumor 1 0.0342 1.60
TCGA Prostate Tumor 5 0.1446 1.75