Hub : Traits :

Asthma (self-reported)

526 significantly associated models · 150 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 7715776 11137778 4 3 4.2e-09 4.1e-09 2.2e-01 96 ENO1 KIF1B RERE
2 1 151055670 152712747 3 3 1.6e-11 1.8e-13 1.0e+00 100 LINGO4 S100A11 TDRKH
3 1 166702558 168182443 1 1 3.0e-12 2.0e-12 1.0e+00 100 CD247
4 1 172311679 173713130 1 1 2.2e-07 4.4e-08 3.5e-09 -16 TNFSF18
5 2 99468341 101456989 1 1 3.4e-07 4.8e-08 5.3e-03 74 AFF3
6 2 101994731 104027106 5 4 2.6e-31 9.1e-51 2.4e-15 72 IL18R1 IL1R1 IL1RL2
7 2 241941773 243048760 9 3 1.4e-24 4.6e-25 2.9e-01 99 D2HGDH ING5
8 3 127097277 128533990 1 1 2.9e-07 6.9e-08 1.0e+00 100 RUVBL1
9 4 38097478 39643536 3 1 1.5e-13 3.6e-15 1.7e-03 84 TLR1
10 4 122377715 123976639 1 1 4.5e-13 4.3e-14 9.2e-03 88 KIAA1109
11 5 108927715 111527482 5 6 4.0e-21 8.1e-40 1.6e-03 94 CAMK4 SLC25A46 TMEM232 TSLP WDR36
12 5 130588008 132900729 17 8 3.8e-23 2.7e-25 NaN NaN AC034220.3 KIF3A P4HA2-AS1 SLC22A5
13 5 140789933 142230251 1 1 1.1e-09 2.9e-09 1.6e-02 84 NDFIP1
14 5 156131251 157697754 1 1 1.2e-09 1.3e-09 9.4e-04 70 ADAM19
15 6 25266147 26682323 1 1 1.6e-07 8.0e-10 1.0e-06 37 TRIM38
16 6 34528785 35987507 2 1 2.1e-08 1.1e-09 7.4e-03 81 ZNF76
17 6 89941356 91704536 1 2 7.0e-18 3.7e-27 3.7e-07 78 BACH2
18 6 134905567 136727603 3 2 2.0e-13 2.5e-09 9.5e-01 100 AHI1 C6orf217
19 7 27171588 28918565 1 1 6.0e-09 1.2e-13 9.3e-07 56 JAZF1
20 10 74879374 76266883 1 1 1.4e-07 4.0e-05 2.9e-01 93 RP11-574K11.5
21 10 93657148 95110026 1 1 1.3e-07 1.7e-08 9.8e-03 79 KIF11
22 11 60549966 62346131 7 1 6.5e-11 3.3e-11 1.0e+00 100 FADS1
23 11 64845438 66333072 3 1 3.6e-09 2.5e-10 1.7e-05 54 EFEMP2
24 11 75369353 77069746 2 2 2.6e-25 2.4e-44 4.9e-16 66 LRRC32 PRKRIR
25 11 110776537 112295421 1 1 7.6e-09 1.1e-09 1.0e+00 100 SIK2
26 12 5809999 6956462 1 1 2.0e-07 1.6e-07 1.1e-01 91 RP1-102E24.8
27 12 47407397 48825686 1 1 6.5e-08 6.5e-06 1.5e-02 71 RP1-197B17.3
28 12 55601472 58677299 8 4 3.4e-16 1.6e-23 4.5e-16 34 AC034102.1 KIF5A STAT6
29 12 70713655 72104017 1 1 4.4e-10 3.0e-10 1.0e+00 100 CTD-2021H9.1
30 12 120502726 122037099 1 1 1.3e-08 6.7e-08 5.1e-02 87 SPPL3
31 13 99047988 100728229 2 1 2.7e-13 6.1e-17 5.0e-07 64 UBAC2
32 15 66662107 68789191 4 3 5.8e-23 8.5e-37 3.1e-13 67 IQCH SMAD3
33 16 10325245 12010444 5 2 4.9e-19 2.3e-26 8.7e-07 79 CLEC16A RP11-396B14.2
34 16 26518263 28065536 4 2 3.3e-13 2.0e-12 9.1e-04 78 CTD-3203P2.1 IL4R
35 17 36660684 39048774 22 6 4.1e-50 1.4e-50 NaN NaN CASC3 GSDMA GSDMB MED24 PNMT
36 17 39559539 41538783 6 2 4.3e-08 1.1e-07 9.8e-02 90 DHX58 RP11-400F19.8
37 17 42442344 43570226 2 2 3.4e-09 3.6e-09 2.7e-02 86 CTD-2020K17.3 NMT1
38 17 46581184 48139500 2 1 2.1e-07 5.9e-16 1.7e-10 38 GNGT2
39 19 15771809 17268784 1 1 1.3e-07 7.8e-06 3.6e-03 58 EPS15L1
40 19 45585167 46994833 2 1 7.6e-09 1.0e-09 4.0e-02 89 DMWD
41 22 41071659 42685537 5 1 5.7e-08 8.0e-08 1.0e+00 100 PMM1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 6.87 16 11 33.3 -0.38 9.8e-02 AC034220.3 BACH2 DHX58 FADS1 GSDMA GSDMB KIAA1109 KIF11 KIF3A LRRC32 MED24 NDFIP1 P4HA2-AS1 RP11-574K11.5 SLC22A5 SMAD3
Irritable Bowel Disease (IBD) 5.93 17 13 39.4 -0.35 1.2e-01 AC034220.3 BACH2 CASC3 DHX58 GSDMA GSDMB KIAA1109 KIF11 KIF3A LRRC32 MED24 NDFIP1 P4HA2-AS1 PRKRIR RP11-574K11.5 SLC22A5 SMAD3
Ulcerative Colitis (UC) 3.04 9 2 6.1 -0.37 3.0e-01 CASC3 GSDMA GSDMB KIAA1109 LRRC32 MED24 P4HA2-AS1 PRKRIR SMAD3
Reaction Time 1.12 1 0 0.0 0.00 1.0e+00 AC034102.1
Verbal and Numeric Reasoning (VNR) 1.23 4 1 3.0 0.21 7.9e-01 AC034102.1 AFF3 C6orf217 FADS1
Breast Cancer 1.93 8 3 9.1 -0.67 4.8e-02 AC034220.3 EFEMP2 KIF1B P4HA2-AS1 RP11-400F19.8 SIK2 SLC22A5 TLR1
Prostate Cancer 1.41 1 1 3.0 0.00 1.0e+00 RUVBL1
Body Mass Index (BMI) (2010) 1.29 1 0 0.0 0.00 1.0e+00 SMAD3
Crohns Disease (2012) 5.29 9 5 15.2 0.55 5.4e-02 AC034220.3 FADS1 GSDMA GSDMB LRRC32 NDFIP1 P4HA2-AS1 SLC22A5 SMAD3
Fasting Glucose 1.57 1 1 3.0 0.00 1.0e+00 FADS1
HDL Cholesterol 2.98 4 4 12.1 0.57 3.2e-01 FADS1 GSDMB KIF5A PNMT
LDL Cholesterol 1.67 1 1 3.0 0.00 1.0e+00 FADS1
Lupus 2.28 3 0 0.0 0.23 7.7e-01 C6orf217 GSDMB ZNF76
Primary Biliary Cirrhosis 2.40 2 1 3.0 0.00 1.0e+00 GSDMB PNMT
Rheumatoid Arthritis 1.72 1 0 0.0 0.00 1.0e+00 GSDMB
Schizophrenia 1.07 1 0 0.0 0.00 1.0e+00 RERE
Triglycerides 2.16 2 2 6.1 0.00 1.0e+00 FADS1 KIF5A
Type 2 Diabetes (T2D) 1.84 1 1 3.0 0.00 1.0e+00 KIF11
Ulcerative Colitis 2.58 3 1 3.0 1.00 2.4e-03 GSDMA GSDMB P4HA2-AS1
Blood Eosinophil Count 21.13 45 41 124.2 -0.87 1.7e-17 AC034102.1 AC034220.3 AHI1 BACH2 CAMK4 CASC3 CD247 CLEC16A CTD-3203P2.1 D2HGDH DMWD EFEMP2 FADS1 GNGT2 GSDMA GSDMB IL18R1 IL1R1 IL1RL2 IL4R ING5 IQCH KIAA1109 KIF11 KIF1B KIF3A LRRC32 MED24 NDFIP1 P4HA2-AS1 PMM1 PRKRIR RERE RP1-102E24.8 RP11-396B14.2 SIK2 SLC22A5 SLC25A46 SMAD3 SPPL3 STAT6 TSLP UBAC2 WDR36 ZNF76
Blood Platelet Count 3.09 23 21 63.6 -0.37 6.0e-02 AC034220.3 C6orf217 DMWD ENO1 FADS1 GSDMB ING5 KIF1B KIF3A KIF5A NDFIP1 NMT1 P4HA2-AS1 PMM1 PNMT RERE RP1-102E24.8 RP1-197B17.3 RUVBL1 SIK2 SLC22A5 SPPL3 STAT6
Blood Red Count 1.34 10 6 18.2 -0.25 4.3e-01 AC034102.1 AFF3 BACH2 FADS1 GSDMB KIF11 KIF5A NDFIP1 PNMT SPPL3
Blood White Count 14.20 24 19 57.6 -0.69 2.6e-05 AC034220.3 AHI1 BACH2 C6orf217 CASC3 CLEC16A EFEMP2 ENO1 EPS15L1 FADS1 GSDMA GSDMB KIF1B KIF3A MED24 NDFIP1 P4HA2-AS1 PNMT RP1-102E24.8 RP11-396B14.2 RP11-400F19.8 SLC22A5 SPPL3 ZNF76
Heel T-Score 1.53 12 11 33.3 0.25 4.4e-01 AC034102.1 BACH2 DHX58 ENO1 FADS1 IQCH JAZF1 KIF1B NMT1 PMM1 RERE ZNF76
BMI 0.95 9 3 9.1 0.43 2.4e-01 AC034102.1 CAMK4 GSDMA IQCH MED24 RP11-400F19.8 RUVBL1 SMAD3 TLR1
Height 2.45 20 12 36.4 0.70 8.8e-05 AC034220.3 AFF3 DMWD FADS1 GNGT2 IQCH JAZF1 KIF11 KIF1B KIF3A NDFIP1 NMT1 P4HA2-AS1 PNMT RERE SLC22A5 SMAD3 SPPL3 STAT6 ZNF76
Waist Hip Ratio (WHR) 1.26 10 2 6.1 0.14 7.1e-01 AFF3 BACH2 DHX58 DMWD GSDMA IQCH MED24 RP11-396B14.2 RP11-400F19.8 SIK2
Systolic Blood Pressure 1.57 10 6 18.2 -0.52 1.2e-01 CTD-2020K17.3 DMWD ENO1 GNGT2 KIF11 NMT1 RERE RUVBL1 SIK2 SMAD3
Smoking Status 1.52 5 2 6.1 -0.14 8.3e-01 AC034102.1 GNGT2 IQCH PMM1 RERE
Allergy or Eczema 21.07 51 40 121.2 -0.92 1.2e-24 AC034102.1 AHI1 BACH2 C6orf217 CAMK4 CASC3 CD247 CLEC16A CTD-2020K17.3 CTD-3203P2.1 D2HGDH DHX58 EFEMP2 ENO1 GSDMA GSDMB IL18R1 IL1R1 IL1RL2 IL4R ING5 IQCH JAZF1 KIAA1109 KIF3A LINGO4 LRRC32 MED24 NDFIP1 NMT1 P4HA2-AS1 PMM1 PRKRIR RERE RP11-396B14.2 RP11-400F19.8 RP11-574K11.5 S100A11 SIK2 SLC22A5 SLC25A46 SMAD3 SPPL3 STAT6 TDRKH TLR1 TMEM232 TNFSF18 TSLP UBAC2 WDR36
Cardiovascular Disease 1.57 8 3 9.1 -0.57 1.4e-01 AC034102.1 GNGT2 NMT1 P4HA2-AS1 RERE SIK2 SLC22A5 ZNF76
Hypothyroidism (self reported) 3.70 10 5 15.2 0.24 4.8e-01 AC034102.1 AHI1 BACH2 C6orf217 CD247 FADS1 PMM1 RERE SPPL3 TLR1
Respiratory disease 26.31 64 55 166.7 -1.00 2.3e-76 AC034102.1 AC034220.3 ADAM19 AHI1 BACH2 C6orf217 CAMK4 CASC3 CD247 CLEC16A CTD-2020K17.3 CTD-2021H9.1 CTD-3203P2.1 D2HGDH DHX58 DMWD EFEMP2 ENO1 FADS1 GNGT2 GSDMA GSDMB IL18R1 IL1R1 IL1RL2 IL4R ING5 IQCH JAZF1 KIAA1109 KIF11 KIF1B KIF3A KIF5A LINGO4 LRRC32 MED24 NDFIP1 NMT1 P4HA2-AS1 PMM1 PNMT PRKRIR RERE RP11-396B14.2 RP11-400F19.8 RP11-574K11.5 RP1-197B17.3 RUVBL1 S100A11 SIK2 SLC22A5 SLC25A46 SMAD3 SPPL3 STAT6 TDRKH TLR1 TMEM232 TNFSF18 TSLP UBAC2 WDR36 ZNF76
Type 2 Diabetes (T2D) 1.55 2 1 3.0 0.00 1.0e+00 KIF11 PNMT
Lung FEV1/FVC ratio 4.74 21 15 45.5 0.76 8.2e-06 AC034102.1 AC034220.3 ADAM19 BACH2 D2HGDH DMWD GNGT2 GSDMB IL18R1 IL1RL2 IQCH MED24 P4HA2-AS1 RERE RP11-396B14.2 RP11-574K11.5 RUVBL1 SLC22A5 SMAD3 STAT6 ZNF76
Lung FVC 2.16 15 9 27.3 -0.01 9.8e-01 AC034102.1 AC034220.3 C6orf217 CLEC16A GNGT2 GSDMB IQCH KIF1B LINGO4 P4HA2-AS1 PNMT RP11-574K11.5 SLC22A5 SPPL3 ZNF76
Neuroticism 1.19 3 0 0.0 0.00 1.0e+00 IQCH PMM1 RERE
Hair Pigment 0.17 7 4 12.1 0.25 5.9e-01 AHI1 FADS1 JAZF1 KIF1B KIF5A RERE ZNF76
Tanning 0.17 2 0 0.0 0.00 1.0e+00 D2HGDH JAZF1
Hand grip strength (left) 2.50 6 4 12.1 -0.98 3.7e-06 AC034220.3 KIF1B KIF3A P4HA2-AS1 SLC22A5 ZNF76
Number of treatments/medications taken 2.53 3 0 0.0 1.00 4.0e-04 CLEC16A FADS1 P4HA2-AS1
Relative age of first facial hair 1.20 1 0 0.0 0.00 1.0e+00 SPPL3
Systolic blood pressure, automated reading 1.47 5 2 6.1 0.91 3.2e-02 DMWD ENO1 KIF11 NMT1 RERE
Angina 1.18 1 0 0.0 0.00 1.0e+00 GNGT2
Vitamin and mineral supplements 1.52 1 0 0.0 0.00 1.0e+00 STAT6
Medication: Metformin 1.37 1 0 0.0 0.00 1.0e+00 KIF11
Impedance of leg (right) 1.14 5 4 12.1 0.61 2.7e-01 AC034102.1 GNGT2 JAZF1 RP11-400F19.8 S100A11
Leg fat-free mass (left) 1.59 8 4 12.1 -0.82 2.2e-03 AC034102.1 AC034220.3 P4HA2-AS1 RP11-400F19.8 SLC22A5 SMAD3 TRIM38 ZNF76
Trunk fat percentage 1.25 7 5 15.2 0.62 1.4e-01 GNGT2 IQCH PMM1 RERE RP11-400F19.8 SMAD3 TRIM38
Hand grip strength (right) 2.70 7 4 12.1 -0.98 2.9e-07 AC034220.3 KIF1B KIF3A P4HA2-AS1 SLC22A5 STAT6 ZNF76
Current tobacco smoking 1.36 1 0 0.0 0.00 1.0e+00 PMM1
Maternal smoking around birth 1.33 1 0 0.0 0.00 1.0e+00 PMM1
Taking other prescription medications 3.69 3 0 0.0 0.98 1.6e-02 D2HGDH GSDMB IL1RL2
Age when periods started (menarche) 1.60 2 0 0.0 0.00 1.0e+00 NMT1 SPPL3
Heel bone mineral density (BMD) T-score, automated (left) 1.21 3 1 3.0 0.00 1.0e+00 DHX58 FADS1 RERE
High blood pressure 1.90 9 3 9.1 0.69 1.4e-02 AC034102.1 AC034220.3 GNGT2 NMT1 P4HA2-AS1 RERE RUVBL1 SIK2 SLC22A5
Hayfever, allergic rhinitis or eczema 18.91 43 35 106.1 0.93 3.7e-23 AC034102.1 AHI1 BACH2 C6orf217 CAMK4 CD247 CLEC16A CTD-3203P2.1 D2HGDH DHX58 EFEMP2 ENO1 GSDMA GSDMB IL18R1 IL1R1 IL1RL2 IL4R JAZF1 KIAA1109 KIF3A LINGO4 LRRC32 MED24 NDFIP1 P4HA2-AS1 PMM1 PRKRIR RERE RP11-396B14.2 RP11-400F19.8 S100A11 SIK2 SLC22A5 SLC25A46 SMAD3 SPPL3 STAT6 TLR1 TMEM232 TNFSF18 TSLP WDR36
Supplements: Glucosamine 1.13 1 0 0.0 0.00 1.0e+00 NMT1
Medication: Levothyroxine sodium 3.29 4 3 9.1 0.04 9.5e-01 AC034102.1 BACH2 C6orf217 FADS1
Sitting height 1.61 8 5 15.2 -0.83 8.8e-04 AC034220.3 DMWD FADS1 GNGT2 P4HA2-AS1 SLC22A5 STAT6 ZNF76
Chronic bronchitis/emphysema (father) 1.83 2 0 0.0 0.00 1.0e+00 IQCH KIF1B
Body mass index (BMI) 1.03 6 2 6.1 -0.02 9.7e-01 AC034102.1 RERE RP11-400F19.8 RUVBL1 SMAD3 TRIM38
Impedance of leg (left) 1.19 6 3 9.1 0.62 1.9e-01 AC034102.1 GNGT2 JAZF1 RP11-400F19.8 S100A11 SLC22A5
Leg predicted mass (left) 1.58 8 4 12.1 -0.82 2.1e-03 AC034102.1 AC034220.3 P4HA2-AS1 RP11-400F19.8 SLC22A5 SMAD3 TRIM38 ZNF76
Trunk fat mass 1.12 7 2 6.1 0.62 1.3e-01 GNGT2 IQCH PMM1 RERE RP11-400F19.8 SMAD3 TRIM38
Waist circumference 1.05 5 3 9.1 -0.09 8.8e-01 AC034102.1 DHX58 IQCH RP11-400F19.8 SMAD3
Past tobacco smoking 1.48 1 1 3.0 0.00 1.0e+00 IQCH
Alcohol usually taken with meals 1.18 1 0 0.0 0.00 1.0e+00 GNGT2
Hair/balding pattern: Pattern 2 1.56 1 0 0.0 0.00 1.0e+00 NMT1
Forced vital capacity (FVC) 1.37 7 2 6.1 -0.75 5.2e-02 C6orf217 IQCH LINGO4 PNMT RP11-574K11.5 TRIM38 ZNF76
Heel bone mineral density (BMD) T-score, automated (right) 1.45 4 1 3.0 -0.98 1.9e-02 DHX58 ENO1 FADS1 RERE
Qualifications: None of the above 1.10 2 1 3.0 0.00 1.0e+00 AC034102.1 AFF3
Heart attack 1.41 1 0 0.0 0.00 1.0e+00 KIF5A
Allergy 25.13 58 47 142.4 -0.97 9.7e-41 AC034102.1 AC034220.3 AHI1 BACH2 C6orf217 CAMK4 CASC3 CD247 CLEC16A CTD-2020K17.3 CTD-3203P2.1 D2HGDH DHX58 EFEMP2 ENO1 EPS15L1 FADS1 GNGT2 GSDMA GSDMB IL18R1 IL1R1 IL1RL2 IL4R ING5 IQCH JAZF1 KIAA1109 KIF11 KIF1B KIF3A KIF5A LINGO4 LRRC32 MED24 NDFIP1 NMT1 P4HA2-AS1 PMM1 PRKRIR RERE RP11-396B14.2 RP11-400F19.8 RP11-574K11.5 S100A11 SIK2 SLC22A5 SLC25A46 SMAD3 SPPL3 STAT6 TDRKH TLR1 TMEM232 TNFSF18 TSLP UBAC2 WDR36
Diabetes (self-reported) 1.49 2 1 3.0 0.00 1.0e+00 KIF11 RP11-400F19.8
Hayfever/allergic rhinitis (self-reported) 9.53 19 11 33.3 0.95 3.2e-12 AC034102.1 BACH2 CAMK4 CD247 CLEC16A D2HGDH GSDMB IL18R1 IL1RL2 KIAA1109 LRRC32 RP11-396B14.2 SLC25A46 SMAD3 TLR1 TMEM232 TNFSF18 TSLP WDR36
Medication: Simvastatin 1.48 2 0 0.0 0.00 1.0e+00 DMWD FADS1
Fluid intelligence score 1.33 3 0 0.0 0.00 1.0e+00 AC034102.1 AFF3 FADS1
Neuroticism score 1.19 2 0 0.0 0.00 1.0e+00 IQCH PMM1
Weight 1.21 8 5 15.2 -0.58 6.2e-02 AC034102.1 AC034220.3 IQCH P4HA2-AS1 RP11-400F19.8 SLC22A5 SMAD3 TRIM38
Impedance of arm (right) 1.54 12 6 18.2 0.56 5.6e-02 AC034102.1 C6orf217 GNGT2 GSDMA JAZF1 KIF1B LRRC32 MED24 NDFIP1 PMM1 RUVBL1 SMAD3
Arm fat percentage (right) 1.23 6 3 9.1 0.70 1.2e-01 IQCH PMM1 RERE RP11-400F19.8 SMAD3 ZNF76
Trunk fat-free mass 1.77 7 6 18.2 -0.98 7.7e-07 AC034102.1 AC034220.3 NMT1 P4HA2-AS1 SLC22A5 STAT6 ZNF76
Hip circumference 0.84 5 1 3.0 -0.90 3.9e-02 AC034102.1 GSDMA MED24 SMAD3 TRIM38
Father's age at death 2.19 2 0 0.0 0.00 1.0e+00 P4HA2-AS1 SLC22A5
Frequency of tiredness / lethargy in last 2 weeks 1.24 1 0 0.0 0.00 1.0e+00 RP11-574K11.5
Hair/balding pattern: Pattern 3 1.25 1 0 0.0 0.00 1.0e+00 AC034220.3
Number of live births 1.27 1 0 0.0 0.00 1.0e+00 FADS1
Forced expiratory volume in 1-second (FEV1) 2.28 11 5 15.2 -0.91 9.1e-05 AC034102.1 ADAM19 C6orf217 LINGO4 P4HA2-AS1 PNMT RP11-574K11.5 RUVBL1 SLC22A5 TRIM38 ZNF76
Pulse rate 1.29 1 1 3.0 0.00 1.0e+00 FADS1
Qualifications: A levels/AS levels or equivalent 0.81 1 0 0.0 0.00 1.0e+00 AC034102.1
Mouth/teeth dental problems: Dentures 1.16 2 0 0.0 0.00 1.0e+00 PNMT TRIM38
Asthma 27.62 68 63 190.9 1.00 1.3e-121 AC034102.1 AC034220.3 ADAM19 AFF3 AHI1 BACH2 C6orf217 CAMK4 CASC3 CD247 CLEC16A CTD-2020K17.3 CTD-2021H9.1 CTD-3203P2.1 D2HGDH DHX58 DMWD EFEMP2 ENO1 EPS15L1 FADS1 GNGT2 GSDMA GSDMB IL18R1 IL1R1 IL1RL2 IL4R ING5 IQCH JAZF1 KIAA1109 KIF11 KIF1B KIF3A KIF5A LINGO4 LRRC32 MED24 NDFIP1 NMT1 P4HA2-AS1 PMM1 PNMT PRKRIR RERE RP1-102E24.8 RP11-396B14.2 RP11-400F19.8 RP11-574K11.5 RP1-197B17.3 RUVBL1 S100A11 SIK2 SLC22A5 SLC25A46 SMAD3 SPPL3 STAT6 TDRKH TLR1 TMEM232 TNFSF18 TRIM38 TSLP UBAC2 WDR36 ZNF76
Medication: Ibuprofen (e.g. Nurofen) 1.51 1 1 3.0 0.00 1.0e+00 STAT6
Prospective memory result 1.16 1 0 0.0 0.00 1.0e+00 RP11-400F19.8
Forced expiratory volume in 1-second (FEV1), Best measure 2.37 11 5 15.2 -0.91 4.4e-05 AC034102.1 ADAM19 LINGO4 P4HA2-AS1 PNMT RERE RP11-574K11.5 RUVBL1 SLC22A5 TRIM38 ZNF76
Impedance of arm (left) 1.51 11 5 15.2 0.61 4.6e-02 AC034102.1 CTD-2020K17.3 GNGT2 GSDMA JAZF1 KIF1B LRRC32 MED24 PMM1 RUVBL1 SMAD3
Arm fat mass (right) 1.01 6 4 12.1 0.20 7.0e-01 AC034102.1 IQCH RERE RP11-400F19.8 SMAD3 TRIM38
Trunk predicted mass 1.77 7 6 18.2 -0.98 7.2e-07 AC034102.1 AC034220.3 NMT1 P4HA2-AS1 SLC22A5 STAT6 ZNF76
Standing height 2.53 11 11 33.3 -0.85 6.2e-05 AC034220.3 DMWD FADS1 GNGT2 KIF3A NMT1 P4HA2-AS1 SLC22A5 SPPL3 STAT6 ZNF76
Tense / 'highly strung' 1.29 2 0 0.0 0.00 1.0e+00 PMM1 RERE
Hair/balding pattern: Pattern 4 1.73 5 1 3.0 0.57 3.1e-01 CTD-2020K17.3 FADS1 KIF1B RERE S100A11
Birth weight of first child 1.75 2 1 3.0 0.00 1.0e+00 AC034102.1 ZNF76
Peak expiratory flow (PEF) 1.60 3 2 6.1 0.00 1.0e+00 ADAM19 SLC22A5 ZNF76
Loud music exposure frequency 1.07 1 0 0.0 0.00 1.0e+00 PNMT
Medication: Paracetamol 1.48 1 0 0.0 0.00 1.0e+00 STAT6
Headache pain in last month 2.06 3 2 6.1 0.00 1.0e+00 AC034102.1 DMWD STAT6
Medication for cholesterol, blood pressure or diabetes 1.31 1 1 3.0 0.00 1.0e+00 SIK2
Gout (self-reported) 1.71 1 1 3.0 0.00 1.0e+00 KIF5A
Hypothyroidism/myxoedema (self-reported) 3.54 6 3 9.1 -0.19 6.8e-01 AC034102.1 AHI1 BACH2 C6orf217 CD247 FADS1
Medication: Ventolin 100micrograms inhaler 10.94 24 4 12.1 0.99 4.6e-22 AC034102.1 AHI1 BACH2 CD247 CLEC16A CTD-2020K17.3 CTD-3203P2.1 D2HGDH GNGT2 GSDMB IL18R1 IL1RL2 ING5 KIAA1109 LRRC32 NDFIP1 PMM1 PRKRIR SLC22A5 SLC25A46 SMAD3 STAT6 TLR1 TSLP
Birth weight 1.61 3 2 6.1 0.00 1.0e+00 KIF11 SIK2 ZNF76
Forced vital capacity (FVC), Best measure 1.35 7 1 3.0 -0.74 5.8e-02 AC034102.1 IQCH LINGO4 PNMT RP11-574K11.5 TRIM38 ZNF76
Body fat percentage 1.27 9 3 9.1 0.67 4.9e-02 GNGT2 IQCH NMT1 PMM1 RERE RP11-400F19.8 SMAD3 TRIM38 ZNF76
Leg fat percentage (right) 1.42 6 3 9.1 0.75 8.3e-02 IQCH NMT1 RERE RP11-400F19.8 SMAD3 TRIM38
Arm fat-free mass (right) 1.57 7 5 15.2 -0.98 3.3e-07 AC034102.1 AC034220.3 NMT1 P4HA2-AS1 SLC22A5 STAT6 ZNF76
Comparative body size at age 10 1.36 2 0 0.0 0.00 1.0e+00 GNGT2 SMAD3
Worry too long after embarrassment 1.24 2 0 0.0 0.00 1.0e+00 C6orf217 IQCH
Seen a psychiatrist for nerves, anxiety, tension or depression 1.22 2 0 0.0 0.00 1.0e+00 FADS1 TRIM38
Wheeze or whistling in the chest in last year 9.49 33 13 39.4 0.98 5.4e-27 ADAM19 AFF3 BACH2 CAMK4 CASC3 CD247 CLEC16A D2HGDH DHX58 DMWD FADS1 GSDMA GSDMB IL18R1 IL1R1 IL1RL2 ING5 KIAA1109 LRRC32 MED24 NMT1 PRKRIR RERE RP11-396B14.2 RP11-574K11.5 SIK2 SLC22A5 SLC25A46 SMAD3 STAT6 TSLP UBAC2 WDR36
Age at first live birth 1.19 1 0 0.0 0.00 1.0e+00 AC034102.1
Shortness of breath walking on level ground 1.58 1 0 0.0 0.00 1.0e+00 LRRC32
Qualifications: College or University degree 1.28 4 2 6.1 -0.28 7.2e-01 AC034102.1 AFF3 PNMT RERE
Eye problems/disorders: None of the above 1.40 1 0 0.0 0.00 1.0e+00 GNGT2
Medication for pain relief, constipation, heartburn 1.36 1 1 3.0 0.00 1.0e+00 STAT6
Medication: Blood pressure 1.49 2 1 3.0 0.00 1.0e+00 GNGT2 SIK2
Angina (self-reported) 1.14 1 0 0.0 0.00 1.0e+00 GNGT2
Migraine (self-reported) 1.82 1 1 3.0 0.00 1.0e+00 STAT6
Medication: Ibuprofen 1.39 1 1 3.0 0.00 1.0e+00 STAT6
Medication: Allopurinol 1.45 1 1 3.0 0.00 1.0e+00 KIF5A
Medication: Seretide 50 evohaler 6.12 6 0 0.0 0.99 5.7e-09 BACH2 D2HGDH IL18R1 P4HA2-AS1 SLC22A5 SMAD3
Whole body fat mass 1.04 7 3 9.1 0.38 4.0e-01 AC034102.1 IQCH PMM1 RERE RP11-400F19.8 SMAD3 TRIM38
Leg fat mass (right) 1.02 6 4 12.1 0.31 5.4e-01 AC034102.1 IQCH RERE RP11-400F19.8 SMAD3 TRIM38
Arm predicted mass (right) 1.58 8 5 15.2 -0.97 6.9e-07 AC034102.1 AC034220.3 MED24 NMT1 P4HA2-AS1 SLC22A5 STAT6 ZNF76
Pulse rate, automated reading 1.59 3 1 3.0 0.00 1.0e+00 AC034102.1 FADS1 SIK2
Alcohol intake frequency. 1.15 5 0 0.0 0.02 9.8e-01 AC034102.1 AFF3 GSDMB RP11-400F19.8 STAT6
Comparative height size at age 10 2.13 8 5 15.2 -0.75 7.6e-03 AC034220.3 DMWD IQCH KIF11 P4HA2-AS1 SLC22A5 SMAD3 ZNF76
Number of full sisters 1.20 1 0 0.0 0.00 1.0e+00 GNGT2
Overall health rating 1.00 1 0 0.0 0.00 1.0e+00 GNGT2
Medication: Aspirin 1.29 1 0 0.0 0.00 1.0e+00 SIK2
Supplements: Vitamin C 1.34 1 0 0.0 0.00 1.0e+00 GSDMB
Knee pain experienced in last month 1.13 1 0 0.0 0.00 1.0e+00 RP11-396B14.2
Hypertension (Self-reported) 1.91 9 3 9.1 0.67 1.7e-02 AC034102.1 AC034220.3 GNGT2 NMT1 P4HA2-AS1 RERE RUVBL1 SIK2 SLC22A5
Illnesses of father: Heart disease 1.75 2 0 0.0 0.00 1.0e+00 SIK2 SMAD3
Smoking status: Previous 1.38 1 0 0.0 0.00 1.0e+00 AC034102.1
Forced expiratory volume in 1-second (FEV1), predicted 2.04 4 4 12.1 -0.96 6.1e-04 AC034220.3 P4HA2-AS1 SLC22A5 ZNF76
Whole body fat-free mass 1.67 7 6 18.2 -0.98 4.1e-07 AC034102.1 AC034220.3 NMT1 P4HA2-AS1 SLC22A5 STAT6 ZNF76
Leg fat-free mass (right) 1.54 7 4 12.1 -0.98 8.7e-07 AC034102.1 AC034220.3 P4HA2-AS1 RP11-400F19.8 SLC22A5 STAT6 ZNF76
Arm fat percentage (left) 1.19 7 4 12.1 0.71 7.5e-02 IQCH PMM1 RERE RP11-400F19.8 SMAD3 TRIM38 ZNF76
Average weekly red wine intake 1.33 1 0 0.0 0.00 1.0e+00 RP11-400F19.8
Mood swings 0.96 1 0 0.0 0.00 1.0e+00 PMM1
Long-standing illness, disability or infirmity 2.16 2 0 0.0 0.00 1.0e+00 IQCH NMT1
Ever had bowel cancer screening 1.26 1 0 0.0 0.00 1.0e+00 SIK2
Diabetes diagnosed by doctor 1.57 1 1 3.0 0.00 1.0e+00 KIF11
Friendships satisfaction 1.01 1 0 0.0 0.00 1.0e+00 EFEMP2
Mouth/teeth dental problems: Mouth ulcers 1.59 1 0 0.0 0.00 1.0e+00 GSDMB
Mineral and other dietary supplements 1.61 1 0 0.0 0.00 1.0e+00 NMT1
Medication: Aspirin 1.24 1 0 0.0 0.00 1.0e+00 SIK2
Illnesses of father: None of the above (group 1) 1.34 1 0 0.0 0.00 1.0e+00 SMAD3
Smoking status: Current 1.25 1 0 0.0 0.00 1.0e+00 PMM1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.35 6 3 9.1 -0.88 8.4e-03 AC034102.1 ADAM19 GSDMB PNMT TRIM38 ZNF76
Whole body water mass 1.70 7 6 18.2 -0.98 4.5e-07 AC034102.1 AC034220.3 NMT1 P4HA2-AS1 SLC22A5 STAT6 ZNF76
Leg predicted mass (right) 1.55 7 4 12.1 -0.98 9.5e-07 AC034102.1 AC034220.3 P4HA2-AS1 RP11-400F19.8 SLC22A5 STAT6 ZNF76
Arm fat mass (left) 1.00 6 4 12.1 0.22 6.7e-01 AC034102.1 IQCH RERE RP11-400F19.8 SMAD3 TRIM38
Number of self-reported non-cancer illnesses 4.56 11 2 6.1 0.95 2.2e-07 D2HGDH GNGT2 GSDMB IL1RL2 IQCH KIF3A LRRC32 P4HA2-AS1 RP11-396B14.2 RUVBL1 SLC22A5
Average weekly champagne plus white wine intake 1.23 1 1 3.0 0.00 1.0e+00 FADS1
Miserableness 1.35 1 0 0.0 0.00 1.0e+00 RERE
Medication: Blood pressure 2.21 6 1 3.0 0.82 1.4e-02 AC034220.3 KIF3A NMT1 P4HA2-AS1 SIK2 SLC22A5
Supplements: Fish oil (including cod liver oil) 1.61 2 0 0.0 0.00 1.0e+00 FADS1 NMT1
High cholesterol (Self-reported) 1.34 1 0 0.0 0.00 1.0e+00 FADS1
Medication: Bendroflumethiazide 2.21 3 0 0.0 0.97 5.4e-03 AC034220.3 P4HA2-AS1 SLC22A5
Medication: Paracetamol 1.26 1 0 0.0 0.00 1.0e+00 NMT1
Ever smoked 1.24 1 0 0.0 0.00 1.0e+00 IQCH
Basal metabolic rate 1.56 7 5 15.2 -0.98 3.5e-07 AC034102.1 AC034220.3 P4HA2-AS1 RP11-400F19.8 SLC22A5 STAT6 ZNF76
Leg fat percentage (left) 1.49 8 1 3.0 0.45 2.6e-01 GSDMA IQCH NMT1 RERE RP11-400F19.8 SMAD3 TRIM38 ZNF76
Arm fat-free mass (left) 1.56 6 5 15.2 -0.99 1.3e-06 AC034102.1 AC034220.3 P4HA2-AS1 SLC22A5 STAT6 ZNF76
Number of operations (self-reported) 1.43 1 0 0.0 0.00 1.0e+00 IQCH
Average weekly beer plus cider intake 1.69 1 0 0.0 0.00 1.0e+00 STAT6
Irritability 1.06 2 0 0.0 0.00 1.0e+00 FADS1 PMM1
Age started oral contraceptive pill 0.90 1 0 0.0 0.00 1.0e+00 AC034102.1
Diastolic blood pressure, automated reading 1.81 5 2 6.1 0.98 4.0e-04 AC034220.3 NMT1 P4HA2-AS1 RERE ZNF76
Myopia 1.77 3 0 0.0 0.00 1.0e+00 FADS1 GSDMB STAT6
Vascular/heart problems diagnosed by doctor 2.03 9 5 15.2 -0.67 1.7e-02 AC034220.3 GNGT2 NMT1 P4HA2-AS1 RERE RUVBL1 SIK2 SLC22A5 SMAD3
Cholesterol lowering medication 1.25 1 0 0.0 0.00 1.0e+00 DMWD
Pain experienced in last month 1.23 1 0 0.0 0.00 1.0e+00 AC034102.1
Basal cell carcinoma (self-reported) 1.62 1 0 0.0 0.00 1.0e+00 PMM1
Heart attack/myocardial infarction (self-reported) 1.48 1 0 0.0 0.00 1.0e+00 KIF5A
Impedance of whole body 1.33 8 5 15.2 0.54 1.7e-01 AC034102.1 GNGT2 JAZF1 KIF1B LRRC32 PMM1 RP11-400F19.8 RUVBL1
Leg fat mass (left) 1.04 7 6 18.2 0.11 8.2e-01 AC034102.1 GSDMA IQCH RERE RP11-400F19.8 SMAD3 TRIM38
Arm predicted mass (left) 1.61 6 5 15.2 -0.98 1.8e-06 AC034102.1 AC034220.3 P4HA2-AS1 SLC22A5 STAT6 ZNF76

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 9 0.2578 1.93
GTEx Adipose Visceral Omentum 9 0.4420 2.02
GTEx Adrenal Gland 5 0.3432 1.83
GTEx Artery Aorta 14 0.4703 1.99
GTEx Artery Coronary 1 0.0845 1.72
GTEx Artery Tibial 20 0.5318 2.06
GTEx Brain Caudate basal ganglia 3 0.3261 1.77
GTEx Brain Cerebellar Hemisphere 5 0.3358 1.98
GTEx Brain Cerebellum 7 0.3532 1.99
GTEx Brain Cortex 9 0.8696 2.07
GTEx Brain Frontal Cortex BA9 5 0.5411 2.02
GTEx Brain Hippocampus 2 0.3817 1.74
GTEx Brain Hypothalamus 2 0.3390 2.02
GTEx Brain Nucleus accumbens basal ganglia 7 0.8092 2.14
GTEx Brain Putamen basal ganglia 4 0.6410 2.08
GTEx Breast Mammary Tissue 10 0.5066 2.07
GTEx Breast Mammary Tissue (Male) 6 0.5029 2.17
GTEx Breast Mammary Tissue (Female) 6 0.3650 1.94
GTEx Cells EBV-transformed lymphocytes 6 0.4216 1.88
GTEx Cells Transformed fibroblasts 22 0.5239 2.13
GTEx Colon Sigmoid 5 0.3420 1.99
GTEx Colon Transverse 11 0.5329 2.08
GTEx Esophagus Gastroesophageal Junction 5 0.3460 1.86
GTEx Esophagus Mucosa 15 0.4518 1.98
GTEx Esophagus Muscularis 13 0.4022 1.97
GTEx Heart Atrial Appendage 7 0.4433 2.14
GTEx Heart Left Ventricle 5 0.3268 1.81
GTEx Liver 3 0.4184 1.88
GTEx Lung 10 0.3481 1.99
GTEx Muscle Skeletal 14 0.4844 2.00
GTEx Nerve Tibial 15 0.3471 1.97
GTEx Ovary 6 0.6608 1.95
GTEx Pancreas 8 0.4902 2.15
GTEx Pituitary 6 0.5381 1.99
GTEx Prostate 4 0.4790 1.87
GTEx Skin Not Sun Exposed Suprapubic 17 0.6913 2.04
GTEx Skin Sun Exposed Lower leg 18 0.4945 2.10
GTEx Small Intestine Terminal Ileum 1 0.2169 1.72
GTEx Spleen 10 0.7087 2.21
GTEx Stomach 5 0.3439 1.87
GTEx Testis 17 0.5388 1.97
GTEx Thyroid 20 0.5001 2.11
GTEx Uterus 2 0.3527 1.81
GTEx Vagina 1 0.1575 1.66
GTEx Whole Blood 13 0.6523 2.30
METSIM Adipose 19 0.4121 1.97
NTR Blood 15 0.6245 2.19
ROSMAP Brain Pre-frontal Cortex 20 0.4555 1.97
YFS Blood 24 0.5197 2.05
CommonMind Brain Pre-frontal Cortex 22 0.4093 1.95
TCGA Breast Tumor 6 0.7823 2.13
TCGA Breast Normal 15 0.3565 1.82
TCGA Ovarian Tumor 7 0.2396 1.74
TCGA Prostate Tumor 15 0.4337 1.93