TWAS hub - TNFSF4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1280	0.0570	7.1e-03	-0.002	NA	0.027	NA	0.002	4.3e-01	NA	2.3e-02	NA	2.6e-01
2	GTEx	Thyroid	0.0790	0.0310	3.1e-03	0.060	NA	0.048	NA	0.054	2.3e-05	NA	1.5e-04	NA	6.0e-05
3	TCGA	Brain Lower Grade Glioma	0.0819	0.0503	1.1e-05	0.067	0.052	0.049	NA	0.056	4.7e-08	1.4e-06	3.1e-06	NA	5.2e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Allergy or Eczema	10.6	27.8	75.3	-1.9	-2.1	8.7
Hayfever, allergic rhinitis or eczema	9.7	21.1	53.6	-1.9	-2.4	7.3
Allergy	9.1	20.8	45.7	3.4	2.3	-6.8
Asthma	9.1	17.9	29.1	-4.5	-2.2	5.4
Asthma (self-reported)	8.9	17.7	30.3	-4.3	-2.0	5.5
Lupus	8.2	12.4	36.4	-6.0	0.1	-0.9
Respiratory disease	8.0	17.8	28.6	-4.5	-2.1	5.4
Rheumatoid Arthritis	7.1	9.8	23.9	-4.9	0.8	2.2
Supplements: Vitamin C	6.3	7.4	10.2	-2.8	-3.2	2.0
Hayfever/allergic rhinitis (self-reported)	5.7	7.6	18.5	-1.9	-0.8	4.3
Medication: Ventolin 100micrograms inhaler	4.8	6.1	12.2	-3.5	-0.4	2.5
Wheeze or whistling in the chest in last year	4.8	8.6	15.4	-3.9	-1.4	2.9
Crohns Disease (2017)	4.4	9.8	19.5	-2.6	-1.8	4.4
Hypothyroidism/myxoedema (self-reported)	4.0	7.9	22.5	-4.7	0.3	-1.0
Bilateral oophorectomy (both ovaries removed)	3.5	4.0	6.5	1.8	2.6	-1.6
Ever had prostate specific antigen (PSA) test	3.4	3.9	5.8	-0.4	-2.4	2.4
Hypothyroidism (self reported)	3.2	7.3	21.8	-4.7	0.0	0.1
Medication: Levothyroxine sodium	3.1	5.3	15.5	-3.9	0.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	3.1	4.9	13.7	0.9	-0.1	-3.7
Vitamin and mineral supplements	3.0	4.0	5.5	2.3	2.3	-1.2
Age at last live birth	3.0	4.3	9.5	-0.7	-1.8	3.1
Pain all over the body in last month	2.9	3.1	8.9	-3.0	-0.6	-0.4
Lung cancer (father)	2.8	3.3	8.3	-2.9	-1.2	-0.4
Illness, injury, bereavement, stress in last 2 years	2.8	3.4	5.1	-0.8	-2.1	2.3
Irritable Bowel Disease (IBD)	2.7	6.5	12.3	-1.8	-2.0	3.5
Medication: Co-codamol	2.6	3.1	7.7	0.1	1.2	-2.8
High blood pressure (siblings)	2.6	3.7	7.7	1.0	1.6	-2.8
Age at first live birth	2.5	4.5	8.5	-1.8	-1.3	2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.4	5.0	7.2	1.8	2.2	-2.7
Heart disease (siblings)	2.4	3.0	6.8	-2.6	1.4	-0.2
Illnesses of siblings: Diabetes	2.3	2.8	7.5	-2.7	0.4	-0.8
Pulse wave Arterial Stiffness index	2.2	2.6	4.0	-2.0	1.8	-0.8
Fractured/broken bones in last 5 years	2.2	2.9	6.6	0.1	1.4	-2.6
Medication: Gliclazide	2.1	2.4	5.8	1.1	0.3	2.4
Number of operations (self-reported)	2.1	3.0	4.4	1.1	2.1	-1.9
Pulse wave peak to peak time	2.0	2.4	3.3	1.8	-1.7	0.9
Average weekly fortified wine intake	1.9	2.3	3.3	1.8	1.2	-1.4
Age when periods started (menarche)	1.9	4.7	8.4	1.9	2.9	-1.5
Number of children fathered	1.9	2.1	5.5	-0.9	-0.4	2.3
Medication: Seretide 50 evohaler	1.9	2.2	5.0	-0.1	-1.3	2.2
Diabetes (self-reported)	1.8	2.8	7.5	0.9	-0.4	2.7
Family relationship satisfaction	1.8	2.2	6.0	-0.2	-2.5	-0.7
Handedness (chirality/laterality): Left-handed	1.8	2.1	6.0	-0.5	-2.5	-0.3
Ever had bowel cancer screening	1.8	2.1	3.3	-1.8	-1.5	0.9
Had other major operations	1.7	2.1	3.9	1.2	2.0	-1.0
Number of live births	1.7	2.4	3.5	1.9	1.0	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	2.6	1.6	1.3	-1.4
Neck or shoulder pain in last month	1.7	2.4	3.9	-0.1	2.0	-1.8
Overall health rating	1.7	3.7	7.9	-2.8	0.9	-1.6
Eye problems/disorders: Glaucoma	1.7	2.0	4.9	-0.4	1.0	-2.2
Lung FVC	1.6	7.9	10.8	2.2	3.3	-2.9
Number of treatments/medications taken	1.6	2.9	3.7	-1.9	-1.2	1.9
Ever had hysterectomy (womb removed)	1.6	1.8	4.3	0.0	2.1	-1.0
Illnesses of siblings	1.6	2.2	3.9	1.6	-0.0	2.0
Prospective memory result	1.6	2.0	2.7	-1.7	0.8	-1.6
Medication: Omeprazole	1.6	1.9	4.0	0.3	2.0	-1.3
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.1	0.3	2.0	-1.3
Glaucoma (self-reported)	1.5	1.8	2.8	0.1	1.6	-1.7
Loneliness, isolation	1.5	2.1	6.2	-2.5	-0.2	-0.0
Tinnitus: Yes, now most or all of the time	1.5	1.7	3.4	-1.1	0.8	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	3.6	0.4	1.3	-1.9
Medication: Ibuprofen	1.4	1.6	2.7	1.7	0.9	-1.1
Friendships satisfaction	1.4	1.8	4.9	0.4	-2.2	-0.6
Ever depressed for a whole week	1.4	1.8	4.0	0.1	-2.0	-1.1
Relative age of first facial hair	1.3	2.7	7.6	2.8	-0.6	0.2
Supplements: Zinc	1.3	1.4	3.1	1.0	-1.8	0.3
Number of incorrect matches in round	1.3	2.2	3.5	-1.9	-1.7	-0.3
Happiness	1.3	1.5	2.7	0.4	-1.3	-1.6
Breastfed as a baby	1.3	1.6	2.5	1.6	1.2	-1.0
Angina (self-reported)	1.3	1.7	3.9	-2.0	0.8	-0.8
Had major operations	1.3	1.5	3.7	-0.8	-0.4	-1.9
Mineral and other dietary supplements	1.3	1.8	1.9	1.3	1.3	-1.4
Mother’s age at death	1.3	1.6	3.6	1.1	-0.3	1.9
Impedance of leg (right)	1.2	5.6	12.7	-1.9	-3.6	-0.6
Serious illness, injury or assault to yourself	1.2	1.5	4.1	-0.5	2.0	-0.1
Blood clot in the leg (DVT)	1.2	1.5	3.0	-1.1	0.5	-1.7
Shortness of breath walking on level ground	1.2	1.5	4.1	-0.0	2.0	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.0	0.2	2.0	0.1
Average weekly champagne plus white wine intake	1.2	1.7	4.3	2.1	-0.4	-0.7
High cholesterol (Self-reported)	1.2	2.1	3.6	1.9	-1.3	1.0
Alcohol drinker status: Never	1.2	1.4	2.1	1.0	1.1	1.4
Alzheimer’s Disease (in mother)	1.1	1.3	2.2	-0.3	-1.3	-1.5
Crohns Disease (2012)	1.1	1.8	3.9	-1.1	-0.4	2.0
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.1	0.7	0.4	-1.8
Angina	1.1	1.4	3.2	-1.8	0.7	-0.7
Falls in the last year	1.1	1.6	3.0	-1.3	-1.7	0.3
Pulse wave reflection index	1.1	1.3	2.7	-1.1	0.4	1.6
Health satisfaction	1.1	1.4	3.1	-0.7	0.8	-1.8
Diabetes diagnosed by doctor	1.1	1.7	3.8	1.2	0.0	2.0
Qualifications: nursing, teaching	1.1	1.7	2.2	1.5	-0.9	-1.4
Supplements: Calcium	1.1	1.2	1.3	-1.1	-1.1	1.1
Bipolar Disorder or Schizophrenia	1.0	2.5	7.5	0.0	-2.7	0.0
Schizophrenia (2018)	1.0	2.0	5.9	-0.1	-2.4	0.2
Taking other prescription medications	1.0	1.5	4.0	-2.0	-0.2	0.7
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.1	0.5	-1.8	-0.6
Alcohol intake versus 10 years previously	1.0	1.5	3.1	-1.8	-0.4	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.9	1.1	0.1	-1.4
Illnesses of mother	1.0	1.2	3.0	0.8	-0.2	1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.2	0.5	-1.8	0.4
Medication: Allopurinol	1.0	1.3	2.0	-0.9	-1.4	1.1
Leg pain on walking	1.0	1.2	3.4	0.5	1.8	0.3
Back pain experienced in last month	1.0	1.4	4.0	-0.2	0.5	-2.0
Illnesses of father: None of the above (group 1)	1.0	1.3	1.8	1.1	-1.3	-0.9
Number of self-reported non-cancer illnesses	1.0	1.7	3.5	-1.1	0.6	1.9
Financial situation satisfaction	1.0	1.3	3.1	0.6	-0.6	-1.8
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.7	-0.8	0.8	-1.6
Mean Putamen Volume	0.9	1.0	2.9	0.3	-0.3	1.7
Sensitivity / hurt feelings	0.9	1.6	2.2	1.5	1.5	0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.9	-0.8	1.4	0.9
Severe depression (siblings)	0.9	1.0	2.8	1.7	0.4	-0.1
Relative age voice broke	0.9	1.4	4.2	2.0	-0.1	-0.1
Impedance of leg (left)	0.9	4.3	8.1	-2.2	-2.8	-0.4
Medication: Cholesterol lowering	0.9	1.4	3.8	-0.5	-0.5	1.9
Gout (self-reported)	0.9	1.2	1.9	-0.3	-1.3	1.4
Comparative body size at age 10	0.9	2.5	6.1	2.5	1.1	-0.3
Number of full brothers	0.9	1.1	2.5	0.4	0.9	-1.6
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.4	0.9	0.2	-1.5
Mean time to correctly identify matches	0.9	1.6	4.2	-0.5	-2.0	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	1.9	1.0	1.4	-0.4
Breast cancer (self-reported)	0.9	1.1	2.2	-0.1	1.5	-1.0
Ever smoked	0.9	1.6	1.8	1.2	-1.3	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.3	-0.0	1.5	-0.9
Pain experienced in last month	0.9	1.5	4.4	-0.1	-0.3	2.1
Schizophrenia vs Biploar Disorder	0.8	1.1	3.2	-1.8	-0.0	0.2
Alzheimer’s Disease (including proxy)	0.8	1.2	1.9	0.0	-1.4	-1.3
Triglycerides	0.8	1.2	2.4	1.5	-0.9	-0.7
Multivitamins +/- minerals	0.8	1.0	2.1	-0.8	-1.4	-0.5
Hair/balding pattern: Pattern 3	0.8	1.3	2.2	-1.0	-0.8	1.5
Birth weight of first child	0.8	1.5	3.1	0.5	1.8	1.1
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.2	0.9	1.1	-0.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.6	0.6	1.0	-1.6
Heart disease (mother)	0.8	1.0	2.4	-1.5	0.8	-0.1
Osteoarthritis (self-reported)	0.8	1.0	2.6	0.1	1.6	0.7
Wears glasses or contact lenses	0.8	1.0	1.6	-0.9	0.7	-1.3
Commuting to job workplace: Public transport	0.8	0.9	2.1	-0.4	-0.7	1.5
Medication: Bendroflumethiazide	0.8	1.3	3.6	-0.2	1.9	-0.5
Depressed Affect (Nagel 2018)	0.7	1.4	3.0	-1.7	0.6	0.9
Alzheimer’s Disease (in father)	0.7	0.7	1.5	-1.2	0.3	-0.8
Major Depression (MDD)	0.7	0.8	1.4	0.8	-1.2	-0.7
Body Mass Index (BMI) (2010)	0.7	0.9	2.5	1.6	-0.4	0.3
HDL Cholesterol	0.7	1.1	2.1	-0.1	-1.1	1.5
Ulcerative Colitis	0.7	1.1	1.8	1.3	-0.5	1.1
Lung FEV1/FVC ratio	0.7	3.4	6.1	1.7	1.1	-2.5
Hand grip strength (left)	0.7	1.9	5.3	2.3	-0.6	-0.2
Supplements: Glucosamine	0.7	0.9	2.0	-0.5	0.7	1.4
Chronic bronchitis/emphysema (father)	0.7	0.8	1.9	-0.3	0.7	1.4
Past tobacco smoking	0.7	1.4	2.4	-1.3	1.6	0.2
Hearing difficulty/problems with background noise	0.7	1.1	2.7	1.6	-0.3	-0.7
Had menopause	0.7	0.9	2.6	0.1	1.6	-0.2
Fluid intelligence score	0.7	1.4	2.1	1.0	-1.0	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.1	0.3	0.3	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	2.8	1.5	1.2	-1.7
Exposure to tobacco smoke at home	0.7	0.8	2.0	0.2	0.7	-1.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	2.0	1.4	-0.2	-1.2
Headache pain in last month	0.7	1.2	2.6	-0.1	-0.9	-1.6
Medication for pain relief, constipation, heartburn	0.7	1.2	1.9	-0.5	-1.2	1.4
Medication: Aspirin	0.7	0.9	1.3	-1.2	-1.0	0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.6	-1.0	-1.3	0.5
Risk taking	0.7	1.1	2.8	1.7	-0.4	0.5
Impedance of whole body	0.7	3.7	6.6	-2.6	-2.1	-0.5
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.5	0.3	-1.9	1.3
Worry (Nagel 2018)	0.6	1.2	3.1	-0.6	0.3	-1.8
Reaction Time	0.6	1.2	3.2	0.4	-1.8	-0.4
Ovarian Cancer	0.6	0.9	2.0	0.7	-0.2	-1.4
Neuroticism (2016)	0.6	0.8	1.4	-0.9	0.5	1.2
Waist Hip Ratio (WHR)	0.6	2.8	5.9	-2.4	-0.9	-1.3
Average weekly spirits intake	0.6	0.8	1.3	-1.0	1.1	-0.1
Diabetes (mother)	0.6	0.7	1.9	0.5	0.0	-1.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.4	-1.2	-0.6	0.2
Alcohol usually taken with meals	0.6	0.9	1.5	0.6	1.0	1.2
Medication: Simvastatin	0.6	0.9	1.4	1.2	-0.2	1.2
Depression (self-reported)	0.6	0.7	1.8	1.4	-0.1	0.4
Loud music exposure frequency	0.6	0.6	0.9	-0.7	-1.0	-0.6
Medication: Paracetamol	0.6	1.0	2.0	0.9	0.4	-1.4
Medication: Amlodipine	0.6	0.8	1.5	0.8	-1.2	0.6
Worry too long after embarrassment	0.6	1.0	1.6	1.2	-0.5	1.1
Qualifications: College or University degree	0.6	2.0	3.8	1.4	-0.5	1.9
Eye problems/disorders: None of the above	0.6	0.7	1.5	-0.6	-0.1	1.2
Knee pain experienced in last month	0.6	0.9	1.7	0.5	1.3	-0.9
Commuting to job workplace: Walk	0.6	0.7	2.0	0.1	1.4	-0.2
Illnesses of father: High blood pressure	0.6	0.7	1.3	0.4	1.1	-0.8
Age started oral contraceptive pill	0.6	0.8	1.6	-0.8	1.3	0.3
Alcohol drinker status: Previous	0.6	0.7	1.7	-0.6	-1.3	-0.3
Blood Red Count	0.5	4.6	10.8	-0.3	1.7	-3.3
Chronotype (morning person)	0.5	1.1	1.6	1.3	-0.6	1.1
Medication: Metformin	0.5	0.8	1.5	0.4	1.2	0.8
Pack years adult smoking proportion	0.5	0.7	1.6	1.3	0.4	0.5
Stomach or abdominal pain in last month	0.5	0.6	1.0	1.0	0.6	-0.7
Medication: Atenolol	0.5	0.6	1.9	1.4	0.2	0.0
Mouth/teeth dental problems	0.5	0.7	1.9	0.4	-0.3	1.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.5	1.6	-0.0	0.9
Length of working week for main job	0.5	0.5	1.3	1.1	0.6	-0.1
Tense / ‘highly strung’	0.5	0.9	1.6	1.0	1.2	-0.3
Hair/balding pattern: Pattern 4	0.5	1.2	2.9	-0.8	-0.1	-1.7
Forced vital capacity (FVC), Best measure	0.5	1.8	2.4	1.2	1.6	-1.3
Exposure to tobacco smoke outside home	0.5	0.6	1.5	0.5	0.3	1.2
Suffer from ‘nerves’	0.5	0.7	1.3	-1.2	-0.6	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.0	0.8	1.0	-0.2
Leg fat-free mass (right)	0.5	2.6	6.0	1.0	2.4	1.0
Smoking status: Current	0.5	0.9	1.7	0.3	1.3	-0.9
Leg predicted mass (right)	0.5	2.7	6.1	1.0	2.5	1.0
Medication: Paracetamol	0.5	0.8	1.5	1.2	0.3	-0.9
Irritability	0.5	0.9	2.0	1.4	0.5	0.7
Cholesterol lowering medication	0.5	0.7	1.7	1.3	0.7	-0.2
Bipolar Disorder (2018)	0.4	0.6	1.8	0.1	-1.3	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.1	0.5	-0.8	1.5
Primary Biliary Cirrhosis	0.4	0.5	1.1	-1.1	0.2	0.7
Schizophrenia (2014)	0.4	0.9	2.8	0.0	-1.7	0.0
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.1	0.6	0.1	1.0
BMI	0.4	2.5	5.6	1.2	2.4	0.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.2	-1.1	0.7	-0.2
Maternal smoking around birth	0.4	0.6	1.1	-1.1	0.6	0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.5	-0.7	0.6	-0.7
Qualifications: None of the above	0.4	0.8	1.3	-1.2	0.9	-0.5
Financial difficulties in last 2 years	0.4	0.6	1.2	-0.7	-0.2	-1.1
Impedance of arm (right)	0.4	1.8	3.8	-1.9	-0.7	-1.0
Arm fat percentage (right)	0.4	1.4	2.7	-1.3	1.7	0.0
Time employed in main current job	0.4	0.4	1.0	0.5	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	2.8	1.7	1.0	-0.9
Pulse rate	0.4	0.6	1.7	0.1	0.5	-1.3
Mouth/teeth dental problems: Dentures	0.4	0.6	1.9	-0.0	1.4	-0.1
Impedance of arm (left)	0.4	1.9	4.5	-2.1	-0.8	-0.8
Migraine (self-reported)	0.4	0.5	1.2	-0.1	-0.5	-1.1
Comparative height size at age 10	0.4	2.0	4.7	-2.2	-0.3	1.1
Chest pain or discomfort	0.4	0.5	1.0	-1.0	0.7	0.3
Medication: Aspirin	0.4	0.6	1.1	-1.1	-0.6	0.4
Smoking status: Previous	0.4	0.6	1.3	0.8	-1.1	0.2
Mood swings	0.4	0.7	2.0	-0.0	1.4	-0.1
Eye problems/disorders: Cataract	0.4	0.4	0.6	0.8	0.4	0.8
Miserableness	0.4	0.7	1.1	1.0	0.9	0.3
Medication: Lisinopril	0.4	0.5	1.4	-0.1	0.1	1.2
Unable to work because of sickness or disability	0.4	0.6	1.3	-0.5	1.2	0.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	0.2	0.1	1.1
Depression (Nagel 2018)	0.3	0.5	1.4	-0.1	0.3	-1.2
Neuroticism (Nagel 2018)	0.3	0.7	1.6	-1.3	0.1	0.6
Ulcerative Colitis (UC)	0.3	0.6	1.1	0.0	-1.0	0.8
Breast Cancer	0.3	0.7	1.3	0.6	-1.1	-0.7
Prostate Cancer	0.3	0.4	0.9	-0.9	-0.6	0.1
Bipolar Disorder (2011)	0.3	0.3	0.8	0.4	-0.9	0.0
Coronary Artery Disease (CAD)	0.3	0.4	0.7	0.6	0.8	0.1
HbA1C	0.3	0.3	0.7	0.8	0.5	0.2
Blood Eosinophil Count	0.3	2.5	5.7	-2.4	0.7	1.1
Heel T-Score	0.3	2.0	4.5	-0.0	-1.2	2.1
Diabetes (father)	0.3	0.4	0.8	0.0	0.9	-0.7
Leg fat-free mass (left)	0.3	1.8	3.7	0.9	1.9	1.0
Trunk fat percentage	0.3	1.2	2.9	-1.7	0.5	0.7
Hand grip strength (right)	0.3	0.9	2.7	1.6	0.0	0.1
Current tobacco smoking	0.3	0.4	1.0	0.2	1.0	-0.6
Fed-up feelings	0.3	0.5	1.3	-1.2	0.3	0.1
Qualifications: CSEs or equivalent	0.3	0.4	0.8	-0.9	-0.1	-0.6
High blood pressure (mother)	0.3	0.4	1.2	-0.4	0.1	-1.1
Body mass index (BMI)	0.3	1.3	3.5	-0.0	1.9	0.7
Leg predicted mass (left)	0.3	1.8	3.3	0.9	1.8	1.1
Trunk fat mass	0.3	1.1	1.8	-1.3	0.7	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	-0.6	0.4	-0.9
Forced vital capacity (FVC)	0.3	1.2	1.9	1.2	1.4	-0.5
Heart attack	0.3	0.3	0.6	-0.1	0.8	0.6
Weight	0.3	1.4	2.5	-0.5	1.6	1.2
Hip circumference	0.3	1.3	2.0	-0.8	1.1	1.4
Father’s age at death	0.3	0.4	0.8	-0.5	-0.6	0.9
Noisy workplace	0.3	0.4	0.8	-0.5	-0.9	0.3
Arm fat mass (right)	0.3	1.1	2.2	-0.8	1.5	0.6
Birth weight	0.3	0.7	2.2	0.0	0.3	1.5
Body fat percentage	0.3	1.0	2.3	-1.5	0.6	0.5
Pulse rate, automated reading	0.3	0.8	2.0	-0.7	0.1	-1.4
Arm fat percentage (left)	0.3	1.2	2.2	-1.2	1.5	0.1
Long-standing illness, disability or infirmity	0.3	0.5	1.1	-1.0	0.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.4	0.3	0.9
Medication for cholesterol	0.3	0.5	1.1	-0.4	-0.4	1.0
Arm fat mass (left)	0.3	1.3	2.7	-0.8	1.7	0.8
Hearing aid user	0.3	0.3	0.5	0.3	0.6	-0.7
Leg fat percentage (left)	0.3	1.0	2.1	-1.4	0.4	0.9
Arm fat-free mass (left)	0.3	1.4	1.5	1.0	1.2	1.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	0.1	1.0	0.4
Fasting Glucose	0.2	0.3	0.6	0.1	0.4	0.8
LDL Cholesterol	0.2	0.3	0.7	0.4	0.2	-0.9
Blood White Count	0.2	1.7	3.9	-0.3	-2.0	1.1
Hearing difficulty/problems: Yes	0.2	0.3	0.4	0.6	-0.7	-0.0
Waist circumference	0.2	0.8	1.6	-1.3	0.8	0.4
Nervous feelings	0.2	0.4	1.0	0.5	-0.1	-1.0
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	0.5	-0.0	-0.8
Medication: Ramipril	0.2	0.3	0.5	0.7	0.6	-0.0
Medication: Lansoprazole	0.2	0.2	0.5	-0.4	0.7	0.1
Peak expiratory flow (PEF)	0.2	0.5	1.1	1.1	0.6	0.3
Leg fat percentage (right)	0.2	0.8	1.9	-1.4	-0.1	0.6
Arm fat-free mass (right)	0.2	1.2	1.8	1.0	0.9	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.8	-0.4	-0.4
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.3	0.2	0.7
Medication: Blood pressure	0.2	0.4	0.7	-0.4	0.6	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.3	0.5	0.5	0.5
Whole body fat mass	0.2	0.8	0.9	-0.9	0.8	1.0
Leg fat mass (right)	0.2	0.7	1.2	-0.9	0.5	1.1
Arm predicted mass (right)	0.2	1.0	1.8	0.9	0.6	1.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.2	-0.5	-0.7
Hypertension (Self-reported)	0.2	0.5	1.1	-0.4	1.1	0.3
Illnesses of father: Heart disease	0.2	0.2	0.4	-0.2	0.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	-1.0	0.0	0.4
Whole body fat-free mass	0.2	1.2	2.1	0.7	1.4	1.0
Osteoporosis (self-reported)	0.2	0.3	0.5	-0.1	-0.6	0.7
Whole body water mass	0.2	1.3	2.2	0.9	1.5	1.0
Medication: Atorvastatin	0.2	0.3	0.4	-0.7	0.6	-0.3
Basal metabolic rate	0.2	1.2	2.1	0.6	1.5	1.0
Commuting to job workplace: Cycle	0.2	0.2	0.3	0.0	-0.6	0.5
Myopia	0.2	0.3	0.4	-0.6	0.6	-0.5
Leg fat mass (left)	0.2	0.9	1.3	-0.8	0.9	1.1
Arm predicted mass (left)	0.2	1.3	1.5	1.0	1.2	1.1
Age at First Birth	0.1	0.1	0.2	-0.5	-0.3	0.1
Smoking Status	0.1	0.3	0.4	0.2	-0.6	0.6
Cardiovascular Disease	0.1	0.3	0.6	-0.8	0.4	-0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	0.5	0.1	0.4
Hair Pigment	0.1	3.4	8.1	-1.4	-0.3	-2.9
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	-0.3	0.6	-0.4
Systolic blood pressure, automated reading	0.1	0.3	0.7	0.2	0.8	0.6
Medication for hormone replacement therapy	0.1	0.2	0.5	-0.1	0.7	-0.2
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.6	0.2	-0.4
High blood pressure	0.1	0.3	0.8	-0.0	0.9	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	0.8	-0.2	0.0
Neuroticism score	0.1	0.2	0.5	0.3	0.7	0.1
Trunk fat-free mass	0.1	0.6	0.8	0.6	0.9	0.9
Worrier / anxious feelings	0.1	0.2	0.6	-0.1	0.3	-0.8
Trunk predicted mass	0.1	0.7	1.1	0.6	1.0	0.8
Standing height	0.1	1.1	1.7	-1.1	-0.5	1.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	-0.6	-0.3	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.3	-0.5	0.1
Alcohol intake frequency.	0.1	0.3	0.7	-0.2	-0.8	0.1
Number of full sisters	0.1	0.1	0.2	0.3	-0.2	0.4
Average weekly red wine intake	0.1	0.2	0.3	0.6	0.4	-0.1
Guilty feelings	0.1	0.1	0.2	-0.3	0.3	-0.4
Medication: Blood pressure	0.1	0.2	0.2	0.5	0.3	-0.4
Diastolic blood pressure, automated reading	0.1	0.2	0.4	0.1	0.6	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.9	0.3	-0.9	-0.3
Pack years of smoking	0.1	0.2	0.3	0.5	0.3	0.4
Blood Platelet Count	0.0	0.3	0.6	0.7	0.5	-0.0
Height	0.0	0.8	1.3	-1.1	0.3	1.0
Systolic Blood Pressure	0.0	0.0	0.1	-0.3	-0.0	0.2
Neuroticism	0.0	0.1	0.2	-0.5	0.3	-0.1
Tanning	0.0	0.3	0.7	0.2	-0.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.1	0.3	-0.1	0.1
Sitting height	0.0	0.2	0.3	-0.4	0.4	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.4	-0.1	0.1
Ever taken oral contraceptive pill	0.0	0.0	0.1	0.1	-0.1	-0.3
Average weekly beer plus cider intake	0.0	0.0	0.1	-0.1	0.0	0.3

Hub : Genes

TNFSF4

Models

Trait associations