Hub : Genes

EPS15L1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0923	0.0397	0.00550	0.009	NA	0.000	NA	0.040	0.05600	NA	0.3300	NA	0.00044
2	GTEx	Cells Transformed fibroblasts	0.1030	0.0420	0.00520	0.035	NA	0.014	NA	0.018	0.00110	NA	0.0300	NA	0.01500
3	GTEx	Esophagus Mucosa	0.0990	0.0400	0.00590	0.020	NA	0.005	NA	0.008	0.01600	NA	0.1400	NA	0.08500
4	GTEx	Esophagus Muscularis	0.1010	0.0380	0.00160	0.017	NA	0.041	NA	0.025	0.03000	NA	0.0016	NA	0.01100
5	METSIM	Adipose	0.0443	0.0195	0.00340	0.020	0.017	0.015	NA	0.022	0.00051	1.0e-03	0.0020	NA	0.00027
6	YFS	Blood	0.0487	0.0178	0.00052	0.000	0.013	0.005	NA	0.002	0.29000	2.3e-05	0.0063	NA	0.07500
7	TCGA	Uterine Corpus Endometrial Carcinoma	0.1740	0.0840	0.00650	0.051	0.048	0.049	NA	0.062	0.01500	1.8e-02	0.0170	NA	0.00810

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.7	1.0	1.8	1.3	-0.5	-1.1	0.3	1.1	1.3	-1.0
Bipolar Disorder or Schizophrenia	0.9	2.2	6.4	1.0	-2.1	-2.5	-0.1	0.4	-1.1	1.5
Depressed Affect (Nagel 2018)	1.5	3.2	6.9	-2.1	-1.3	-1.4	-2.5	-2.6	0.1	1.3
Depression (Nagel 2018)	1.4	2.2	4.1	-1.6	-1.3	-0.5	-1.7	-1.9	-0.4	2.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.0	0.8	-1.0	-0.8	-0.7	0.3	0.2	0.6
Neuroticism (Nagel 2018)	0.6	1.3	4.2	-1.3	-0.8	-0.8	-2.0	-1.4	-0.0	0.1
Schizophrenia (2018)	1.2	2.5	5.4	0.2	-2.3	-2.3	-0.1	-0.5	-1.6	2.0
Schizophrenia vs Biploar Disorder	0.7	1.0	2.9	-1.2	0.4	0.2	-0.2	-1.2	-1.7	0.7
Worry (Nagel 2018)	0.3	0.7	2.6	-1.0	0.2	0.1	-1.6	-0.9	0.2	-0.3
Alzheimer’s Disease (in mother)	0.8	1.0	3.0	-1.4	-0.1	-0.7	-0.9	-1.7	0.7	0.1
Alzheimer’s Disease (in father)	0.3	0.4	1.1	0.0	-0.9	-0.8	-0.1	-0.0	-0.2	1.0
Alzheimer’s Disease (including proxy)	0.7	1.1	2.0	-0.8	-1.0	-1.1	-0.7	-1.4	0.0	1.4
Crohns Disease (2017)	0.4	0.8	4.4	-0.1	-0.6	0.4	-0.5	-0.2	-0.5	2.1
Irritable Bowel Disease (IBD)	0.6	1.3	4.0	1.0	0.2	0.8	1.0	1.6	-2.0	0.2
Ulcerative Colitis (UC)	1.8	3.3	5.5	1.4	1.0	1.3	2.0	2.3	-2.2	-2.0
Major Depression (MDD)	0.9	1.0	3.2	0.2	0.0	-1.8	0.7	-1.2	1.4	0.3
Reaction Time	0.9	1.7	4.8	0.9	-0.5	-0.6	2.2	1.4	-1.6	-1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.7	0.4	-1.0	-1.3	-0.8	-0.3	0.4	1.0
Breast Cancer	0.6	1.4	5.1	0.2	-1.6	0.1	0.6	-0.9	0.8	-2.3
Ovarian Cancer	0.9	1.2	4.0	0.8	-2.0	-0.6	1.8	0.2	0.1	-0.5
Prostate Cancer	0.8	1.2	4.0	-0.4	2.0	0.7	1.0	0.3	-1.5	0.4
Age at First Birth	0.5	0.7	2.1	0.5	0.9	0.7	0.1	1.4	1.1	0.8
Bipolar Disorder (2011)	0.5	0.5	1.8	0.0	0.0	0.0	0.0	0.0	1.2	-1.3
Body Mass Index (BMI) (2010)	0.6	0.8	2.3	0.4	-1.4	-1.5	0.7	-0.6	0.1	-0.4
Coronary Artery Disease (CAD)	0.9	1.0	3.6	-1.4	0.0	0.5	-1.0	-1.9	0.3	-0.7
Crohns Disease (2012)	0.9	1.4	4.9	-0.3	-1.2	-0.4	-1.2	-1.0	-1.0	2.2
Mean Putamen Volume	0.5	0.6	1.8	-0.4	0.2	0.5	-0.5	-0.2	1.3	-1.3
Fasting Glucose	0.9	1.1	2.9	-1.0	-1.4	-0.9	-0.9	-1.7	-0.1	-0.6
HbA1C	0.4	0.4	1.3	0.0	-1.1	-0.6	-0.1	-0.7	-1.0	0.0
HDL Cholesterol	0.5	0.9	2.9	0.6	0.0	1.4	1.7	0.0	-1.0	-0.1
LDL Cholesterol	1.1	1.8	5.2	-2.3	0.0	0.7	-1.5	-1.8	-0.8	0.8
Lupus	0.9	1.4	3.8	1.9	-0.3	-1.0	1.3	1.4	-1.0	0.2
Neuroticism (2016)	0.7	1.1	3.2	-0.9	-0.2	0.1	-1.8	-0.8	0.9	1.3
Primary Biliary Cirrhosis	0.6	0.8	1.9	0.1	-1.2	-0.8	0.7	-0.3	-1.4	-1.0
Rheumatoid Arthritis	0.9	1.3	8.0	0.7	-0.4	-0.0	-0.6	-0.4	-2.8	-0.2
Schizophrenia (2014)	1.4	3.0	6.0	1.5	-2.4	-2.4	0.8	0.7	-1.2	2.1
Triglycerides	0.1	0.2	0.6	-0.2	0.0	-0.6	0.5	-0.3	0.4	0.8
Type 2 Diabetes (T2D) (2012)	1.0	1.1	3.2	-1.7	0.0	0.1	-0.6	-1.2	-1.8	0.3
Ulcerative Colitis	1.6	2.3	5.0	1.5	0.4	0.5	1.8	2.2	-2.0	-0.9
Blood Eosinophil Count	2.6	19.7	121.0	1.8	1.3	0.7	2.2	2.1	1.4	-11.0
Blood Platelet Count	0.2	2.7	6.8	2.0	-0.2	-0.1	2.2	1.9	2.6	-0.4
Blood Red Count	0.7	6.5	20.5	-4.5	-0.2	-0.5	-2.0	-4.4	0.4	1.3
Blood White Count	11.6	86.3	201.6	14.2	1.6	2.3	13.3	14.0	-0.1	-4.6
Heel T-Score	0.9	6.8	16.5	-2.5	-0.9	-1.5	-2.9	-2.7	2.5	4.1
BMI	0.3	1.5	3.7	-1.8	1.0	0.3	-1.9	-1.7	0.0	0.3
Height	0.2	4.2	9.4	1.6	1.6	1.4	-1.9	1.8	-2.6	3.1
Waist Hip Ratio (WHR)	0.2	1.0	2.5	-0.3	0.9	0.8	-1.6	0.7	-0.4	1.6
Systolic Blood Pressure	0.2	1.0	2.5	-1.6	0.2	0.6	0.1	-1.1	-1.3	1.0
Smoking Status	1.4	3.4	7.6	-2.2	-1.0	-1.2	-2.4	-2.8	0.1	1.7
Allergy or Eczema	1.4	3.6	8.5	-2.9	0.5	0.1	-2.9	-2.5	-0.0	1.2
Cardiovascular Disease	1.1	3.6	12.2	-3.1	-0.1	0.1	-1.3	-3.5	1.3	0.7
Hypothyroidism (self reported)	1.6	3.8	21.3	-1.1	0.3	1.2	0.3	-0.4	-1.5	-4.6
Respiratory disease	1.6	3.5	8.9	-2.7	-0.2	0.0	-3.0	-2.4	0.7	1.2
Type 2 Diabetes (T2D) (2018)	1.1	2.1	4.8	-2.2	1.8	1.8	-0.7	-1.7	-0.5	-0.0
Lung FEV1/FVC ratio	0.8	4.0	11.0	2.0	0.5	1.1	3.3	2.4	-1.8	1.6
Lung FVC	0.2	1.0	2.2	1.2	-0.4	-0.5	1.4	1.5	-0.4	-1.0
Neuroticism	1.1	2.8	6.4	-1.9	-1.4	-1.2	-2.5	-2.3	0.6	0.6
Chronotype (morning person)	1.5	3.5	7.2	1.9	-0.4	0.3	2.7	2.4	-2.5	-0.9
Hair Pigment	0.0	0.2	0.7	0.1	-0.3	0.3	-0.0	0.0	0.8	-0.6
Tanning	0.0	0.1	0.3	0.0	0.6	0.1	0.3	-0.5	-0.0	0.5
Hand grip strength (left)	0.3	0.8	3.4	-0.6	-0.0	-0.1	-1.2	-0.2	-0.0	1.8
Number of treatments/medications taken	0.5	0.9	2.2	-1.1	0.9	1.5	-0.8	-1.1	-0.0	-0.4
Average weekly spirits intake	1.7	2.1	6.5	-2.1	1.2	1.2	-0.9	-2.6	-0.0	-0.2
Sensitivity / hurt feelings	0.5	0.8	2.4	-0.6	-0.6	-0.7	-1.5	-0.9	-0.9	-0.6
Frequency of depressed mood in last 2 weeks	1.7	2.3	5.0	-2.2	-0.1	-0.4	-2.0	-2.1	-0.5	1.6
Hearing difficulty/problems: Yes	0.6	0.9	2.8	0.0	1.6	1.7	-0.5	0.6	0.6	0.3
Relative age of first facial hair	0.3	0.5	1.2	0.2	-0.4	0.5	-1.1	0.2	0.9	1.1
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.4	0.3	1.5	1.0	1.3	1.8	0.3	-1.4
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.9	-0.1	-0.2	-0.2	0.2	-0.3	-0.5	-1.4
Ever had hysterectomy (womb removed)	0.8	0.9	3.6	0.3	-1.6	-1.9	0.5	0.1	-0.2	0.2
Systolic blood pressure, automated reading	0.4	1.2	2.7	-1.4	-0.6	0.4	-1.0	-1.5	-0.3	1.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.1	0.4	-1.0	0.8	0.9	0.4	-1.0	-1.1
Angina	1.0	1.3	5.9	-1.4	0.2	-0.5	0.1	-2.4	-0.8	0.2
Medication for hormone replacement therapy	1.4	1.6	4.3	2.1	-1.0	-0.9	1.0	1.1	-0.5	-1.5
Vitamin and mineral supplements	0.5	0.7	1.6	-1.2	0.4	0.7	-1.2	-0.8	0.7	-0.5
Supplements: Zinc	0.9	0.9	2.5	-0.6	-0.7	-1.6	-0.7	-0.8	-0.6	1.3
Medication: Co-codamol	0.3	0.4	0.8	-0.8	0.7	-0.2	-0.8	-0.9	-0.4	-0.1
Medication: Metformin	0.4	0.5	1.8	-0.4	0.8	1.3	0.1	-0.5	-0.8	-0.1
Diabetes (father)	2.3	2.9	4.7	2.0	-1.4	-1.4	2.1	2.2	1.6	-0.9
Diabetes (mother)	0.9	1.1	3.4	-1.2	-1.0	-1.8	0.0	-1.4	0.2	-0.1
Severe depression (siblings)	3.5	3.9	5.9	2.4	-2.4	-2.4	1.8	1.6	-1.3	-1.6
Pack years adult smoking proportion	0.5	0.7	1.9	-1.2	0.9	-0.1	-0.5	-0.8	-0.1	-1.4
Impedance of leg (right)	0.1	0.4	0.8	-0.4	-0.6	-0.4	-0.9	-0.9	-0.7	0.6
Leg fat-free mass (left)	0.1	0.4	1.4	-0.1	0.7	-0.2	-0.8	0.5	-0.2	1.2
Trunk fat percentage	1.7	7.0	17.2	-4.1	1.8	0.7	-3.6	-3.7	0.3	0.9
Hand grip strength (right)	0.1	0.4	0.6	0.4	-0.2	0.7	-0.7	0.8	-0.1	0.7
Townsend deprivation index at recruitment	0.6	0.8	2.0	0.6	-1.0	-0.9	0.5	0.2	1.4	-1.1
Current tobacco smoking	0.2	0.3	0.8	-0.5	-0.3	-0.9	-0.5	-0.9	0.1	-0.5
Average weekly fortified wine intake	0.9	1.1	1.9	0.8	1.3	1.4	-0.5	1.3	-1.0	-0.8
Maternal smoking around birth	2.1	3.1	7.9	-2.3	0.6	-0.1	-2.8	-2.2	1.7	0.6
Fed-up feelings	1.8	3.3	6.7	-1.4	-2.6	-2.0	-2.3	-2.2	0.0	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	7.1	-2.1	-0.6	-0.8	-2.1	-1.7	1.3	2.7
Relative age voice broke	0.7	1.0	3.6	0.7	-1.5	0.4	-0.3	-0.5	0.7	1.9
Taking other prescription medications	1.9	2.9	8.8	-2.5	0.8	0.4	-2.0	-3.0	-0.7	-0.1
Age when periods started (menarche)	1.1	2.7	5.4	2.3	-0.5	-0.5	1.9	2.3	-1.9	0.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.6	0.1	-0.5	-0.3	1.1	1.0	0.5	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	6.1	-1.8	-0.9	-1.2	-2.1	-2.1	1.4	2.5
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	4.4	-2.0	1.0	-0.5	-1.3	-2.1	1.6	1.2
Qualifications: CSEs or equivalent	1.1	1.5	3.1	1.4	-1.1	-1.8	1.1	1.3	0.0	-1.2
Serious illness, injury or assault to yourself	0.3	0.4	1.6	-0.3	0.1	-0.1	0.5	-1.3	-0.9	0.2
High blood pressure	0.8	2.3	9.0	-2.5	0.5	0.6	-0.5	-3.0	0.2	0.0
Hayfever, allergic rhinitis or eczema	1.0	2.2	6.0	-2.0	0.2	-0.3	-2.4	-1.9	-0.7	0.9
Multivitamins +/- minerals	0.3	0.4	1.0	0.2	-0.4	-1.0	0.5	-0.2	1.0	0.6
Stomach or abdominal pain in last month	1.0	1.2	3.8	1.3	-0.4	-0.8	1.4	2.0	-0.1	-0.3
Supplements: Glucosamine	0.5	0.7	1.9	-1.1	0.8	0.1	-1.4	-0.4	1.1	-0.2
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.6	0.1	-1.6	-1.4	0.1	0.0	-1.3	0.2
Medication: Atenolol	2.2	2.7	8.4	-1.8	-0.3	-1.1	-1.7	-2.9	0.8	1.5
Medication: Levothyroxine sodium	1.0	1.8	8.6	-0.8	0.1	0.6	0.6	-0.6	-1.4	-2.9
Sitting height	0.1	0.8	2.5	0.5	0.9	0.0	-1.4	0.4	0.2	1.6
Chronic bronchitis/emphysema (father)	1.1	1.3	3.3	-0.8	-0.6	0.2	-0.9	-1.8	-0.7	-1.8
High blood pressure (mother)	1.4	2.0	4.7	-1.5	2.2	1.3	-1.7	-0.7	0.4	1.4
Body mass index (BMI)	0.9	4.0	10.6	-3.3	0.8	0.0	-2.5	-2.9	1.2	0.7
Impedance of leg (left)	0.1	0.3	0.8	-0.4	-0.2	0.0	-0.8	-0.9	-0.8	0.4
Leg predicted mass (left)	0.1	0.4	1.2	-0.1	0.6	-0.2	-0.8	0.5	-0.3	1.1
Trunk fat mass	1.2	5.3	11.9	-3.5	1.7	0.6	-3.3	-3.0	0.2	1.3
Waist circumference	1.4	5.1	12.0	-3.2	1.5	0.7	-3.5	-2.6	1.2	1.6
Number of incorrect matches in round	0.6	1.0	2.4	-0.4	1.5	1.4	0.3	1.0	-0.4	1.0
Past tobacco smoking	3.7	6.8	13.7	3.7	0.4	1.0	3.3	3.6	-0.3	-2.9
Alcohol usually taken with meals	0.8	1.3	2.2	1.1	1.1	0.8	1.5	1.3	-0.5	-1.4
Nervous feelings	0.4	0.7	1.7	-0.3	1.2	1.3	-1.3	-0.2	-0.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.4	-1.8	0.0	-0.3	-2.1	-1.0	0.7	0.7
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.4	0.1	0.2	0.2	0.3	0.5	0.3
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	-0.0	-0.0	-0.6	-0.5	0.5	1.1	-1.0
Had menopause	1.6	2.1	5.5	-1.9	0.6	-0.2	-2.4	-2.2	0.1	0.1
Had other major operations	1.1	1.3	3.9	0.2	-0.3	-0.7	1.6	0.9	-2.0	-1.2
Forced vital capacity (FVC)	0.3	1.2	3.9	1.9	-0.5	-0.3	-0.6	2.0	-0.5	0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	3.5	-1.2	-1.1	-1.8	-1.6	-1.2	1.5	1.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.5	-0.5	-0.7	-0.8	0.1	-0.4	-0.8	-1.2
Qualifications: None of the above	0.9	1.9	4.4	-2.1	1.4	1.3	-1.2	-0.9	1.4	0.9
Financial difficulties in last 2 years	1.6	2.1	4.7	1.2	-2.2	-2.0	-0.3	0.2	1.4	1.6
Mouth/teeth dental problems	0.6	1.0	2.8	0.8	0.3	1.0	1.4	1.7	0.4	-0.1
Heart attack	1.8	2.4	7.1	-2.7	1.3	0.6	-0.7	-2.6	-0.1	0.0
Allergy	3.8	8.7	22.7	4.2	-1.2	0.1	4.8	3.4	-1.1	-2.5
Pain all over the body in last month	1.6	1.7	6.0	-1.4	-0.5	0.1	-1.5	-2.5	0.9	-0.8
Diabetes (self-reported)	2.3	3.6	7.7	-2.7	2.2	2.8	-1.4	-1.9	-0.1	-0.2
Hayfever/allergic rhinitis (self-reported)	1.9	2.6	5.2	-2.0	1.8	2.3	-2.0	-0.9	-0.9	0.0
Medication: Ramipril	0.7	0.9	3.8	-0.7	0.1	0.8	0.0	-1.0	-0.5	-1.9
Medication: Simvastatin	1.0	1.5	6.2	-1.5	-0.4	0.1	0.5	-2.5	1.2	-0.2
Fluid intelligence score	0.2	0.5	0.8	0.5	-0.9	-0.8	-0.9	-0.4	0.5	0.6
Illnesses of siblings	0.9	1.2	2.6	-1.2	1.1	0.9	-1.6	-1.0	-0.6	1.0
Neuroticism score	1.9	4.0	11.4	-2.3	-1.0	-1.0	-3.4	-2.7	0.7	1.3
Weight	0.6	3.0	8.0	-2.2	1.2	0.3	-2.8	-1.9	0.4	1.7
Impedance of arm (right)	0.2	1.0	2.7	-1.3	0.6	0.2	-1.7	-1.0	-1.0	0.5
Arm fat percentage (right)	1.8	7.2	19.0	-4.4	1.4	0.3	-3.7	-3.9	0.7	0.3
Trunk fat-free mass	0.1	0.8	2.5	1.3	0.5	0.2	0.1	1.6	-0.3	1.2
Hip circumference	0.7	2.9	6.1	-2.5	1.0	0.1	-2.3	-2.4	1.3	0.7
Time employed in main current job	1.0	1.1	4.2	1.2	0.1	1.0	0.7	2.1	-0.7	0.5
Alcohol intake versus 10 years previously	1.2	1.7	3.2	-1.8	0.3	0.6	-1.6	-1.4	1.8	1.0
Father’s age at death	3.3	4.4	15.1	2.3	-0.4	-0.9	3.9	2.6	-1.0	-1.4
Worrier / anxious feelings	0.5	0.9	3.7	-1.1	0.0	-0.2	-1.9	-1.0	-0.4	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	3.0	-1.3	0.2	-0.0	-1.5	-1.2	-1.7	0.2
Falls in the last year	0.1	0.1	0.6	-0.1	0.3	0.1	0.1	-0.6	0.2	-0.7
Hair/balding pattern: Pattern 3	0.3	0.5	1.4	-0.6	0.0	0.9	0.3	-0.5	0.7	1.2
Number of live births	1.5	2.2	4.5	0.9	0.0	1.0	2.1	2.1	-0.2	-2.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	5.2	2.1	-0.8	-0.5	0.3	2.3	-0.5	0.6
Pulse rate	0.8	1.4	2.8	-1.4	1.2	1.1	-1.7	-0.9	0.1	1.2
Happiness	0.4	0.4	2.4	-0.0	-0.1	-1.6	-0.5	-0.3	-0.2	0.4
Noisy workplace	0.3	0.4	0.8	0.9	-0.9	-0.6	0.1	0.7	0.3	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.3	1.2	0.6	-0.3	-0.2	0.2	0.7	-1.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	4.6	2.0	-0.7	0.4	2.1	1.0	-0.6	-1.5
Mouth/teeth dental problems: Dentures	1.5	2.6	6.7	-2.6	0.5	0.1	-2.2	-2.2	0.7	1.1
Asthma	4.6	9.1	26.2	-4.0	0.8	0.0	-5.1	-3.6	0.3	2.6
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.3	3.4	1.4	1.2	1.8	0.5	1.4	0.1	-0.4
Medication: Cholesterol lowering	0.9	1.4	5.7	-1.8	-0.6	-0.0	-0.1	-2.4	-0.5	0.8
Depression (self-reported)	0.2	0.2	1.0	0.5	-0.4	-0.1	1.0	0.1	0.1	-0.5
Medication: Lansoprazole	1.0	1.2	2.7	-0.9	-1.1	-1.1	-0.9	-1.0	0.8	-1.6
Prospective memory result	0.5	0.6	1.3	0.2	0.3	0.0	1.2	1.1	-1.2	0.2
Lung cancer (father)	0.5	0.6	1.6	-1.3	-0.8	-0.2	-0.8	-0.7	0.2	0.9
Illnesses of mother	2.9	3.6	8.6	2.9	-2.5	-1.7	1.7	2.1	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	9.2	2.9	-1.4	-0.5	1.1	3.0	-0.4	0.7
Pulse wave Arterial Stiffness index	1.3	1.5	3.8	-1.9	0.4	0.0	-1.7	-1.8	-0.6	0.5
Impedance of arm (left)	0.1	0.6	1.0	-1.0	1.0	0.7	-0.8	-0.8	-0.7	-0.4
Arm fat mass (right)	1.0	4.3	10.9	-3.3	1.1	0.2	-2.9	-2.9	0.2	0.9
Trunk predicted mass	0.2	0.9	3.0	1.5	0.3	0.1	0.2	1.7	-0.3	1.1
Standing height	0.3	2.8	5.5	2.1	1.2	0.7	-0.9	2.2	-1.5	2.3
Length of working week for main job	2.0	2.2	14.3	-0.3	-0.1	-0.4	-0.9	0.1	-0.2	3.8
Exposure to tobacco smoke at home	1.2	1.3	3.8	-0.8	-0.5	-1.9	-0.5	-1.5	-0.3	1.3
Breastfed as a baby	1.5	1.9	4.2	-1.3	0.6	1.1	-2.1	-1.2	1.9	0.6
Tense / ‘highly strung’	0.3	0.4	0.9	-0.7	-0.7	-0.9	-0.2	-0.5	0.9	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	7.2	-1.7	-1.1	-2.0	-1.9	-2.7	-0.8	1.1
Hair/balding pattern: Pattern 4	0.3	0.7	1.8	-0.6	-0.4	-0.7	-1.0	-1.3	0.0	1.1
Birth weight of first child	1.2	2.2	6.6	1.0	1.4	2.6	0.9	1.6	-1.5	-0.7
Peak expiratory flow (PEF)	0.2	0.4	0.8	0.0	-0.6	-0.7	-0.8	0.6	0.9	0.0
Pulse wave reflection index	1.2	1.4	3.7	-1.4	-0.6	-1.2	-1.9	-1.5	-0.5	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	0.1	-0.6	-0.6	-0.3	-0.5	-0.3	0.1
Loud music exposure frequency	0.8	0.8	2.1	-0.5	1.2	0.7	-1.5	0.1	0.3	1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.5	0.9	-1.0	-1.2	1.2	0.2	-0.1	-0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.6	-0.6	-0.1	-1.1	-0.0	-1.2	-0.6	-0.3
Blood clot in the leg (DVT)	0.8	1.0	4.2	-0.6	0.5	-1.4	-0.2	-0.4	2.0	0.0
Medication: Paracetamol	0.3	0.5	1.1	0.8	0.2	0.4	0.9	1.0	0.6	-0.6
Headache pain in last month	2.0	3.4	6.2	2.2	-1.3	-1.1	1.8	2.0	-1.6	-2.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	4.3	1.4	0.2	-0.9	0.5	2.1	0.9	0.1
Glaucoma (self-reported)	0.5	0.6	1.4	0.6	-0.1	0.1	1.1	0.8	-0.5	1.2
Gout (self-reported)	0.3	0.4	1.4	0.1	-0.1	-0.9	-0.5	-0.3	1.2	0.4
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	10.8	-1.1	0.3	0.8	0.1	-0.2	-1.5	-3.3
Medication: Amlodipine	1.9	2.7	5.3	-2.2	1.5	1.4	-2.3	-2.0	-0.2	-0.3
Medication: Ventolin 100micrograms inhaler	1.4	1.8	5.4	-0.9	1.3	1.2	-2.3	-0.2	1.4	1.1
Birth weight	0.3	0.7	2.8	-0.7	0.9	1.7	-0.3	-0.2	0.1	0.7
Chronic bronchitis/emphysema (mother)	1.4	1.6	8.0	-0.1	1.2	2.8	-0.9	0.6	-0.8	0.0
High blood pressure (siblings)	1.0	1.4	2.9	1.7	-1.1	-1.1	1.3	1.6	-0.2	-0.5
Forced vital capacity (FVC), Best measure	0.6	2.2	6.5	2.5	-1.0	-0.6	0.4	2.6	-0.5	0.6
Body fat percentage	1.7	6.9	17.2	-4.2	1.6	0.6	-3.4	-4.0	0.6	0.5
Leg fat percentage (right)	1.7	6.1	16.5	-4.1	0.8	-0.1	-2.9	-4.0	0.9	0.8
Arm fat-free mass (right)	0.1	0.5	1.5	1.1	0.6	0.4	0.2	1.2	-0.0	0.4
Exposure to tobacco smoke outside home	1.0	1.3	3.1	1.0	-1.5	-1.8	1.3	-0.0	0.8	-0.3
Comparative body size at age 10	0.4	1.1	3.4	-1.5	0.3	0.2	-0.9	-1.8	0.2	0.8
Number of full brothers	0.5	0.6	1.7	0.1	-0.4	-1.3	-0.4	0.3	1.0	-1.2
Worry too long after embarrassment	0.2	0.4	1.2	0.6	-0.2	0.3	-0.8	1.1	-0.2	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.7	-0.3	-0.7	-0.9	-0.1	0.3	-1.7	0.0
Wheeze or whistling in the chest in last year	2.2	4.0	7.6	-2.7	-1.0	-1.5	-2.8	-2.6	1.3	1.0
Number of children fathered	0.8	0.9	1.9	0.5	1.4	0.7	-0.4	1.2	1.2	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.1	-0.8	1.1	1.0	0.5	-1.1	0.5	-0.4
Age at first live birth	0.8	1.4	4.0	0.3	1.7	2.0	1.5	1.0	0.2	-0.1
Pulse wave peak to peak time	1.2	1.4	3.9	2.0	-0.3	-0.1	1.6	1.8	0.4	-0.3
Health satisfaction	0.7	0.9	3.0	-1.7	0.9	0.5	-0.8	-1.2	-0.6	-0.1
Shortness of breath walking on level ground	0.7	0.8	3.9	-0.2	0.0	0.4	0.8	0.3	-0.8	-2.0
Qualifications: College or University degree	0.5	1.6	4.0	1.6	0.6	0.9	0.4	1.6	-2.0	-0.6
Eye problems/disorders: None of the above	0.8	0.9	3.6	-0.2	1.0	-0.5	-0.7	0.3	1.9	-0.9
Mouth/teeth dental problems: Loose teeth	2.3	2.7	6.4	-2.3	1.0	-0.1	-2.5	-2.4	0.9	0.6
Emphysema/chronic bronchitis	0.2	0.3	1.1	-0.6	0.1	-0.3	0.4	0.4	0.2	-1.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	-0.1	-0.5	-0.8	0.1	-0.3	0.4	0.7
Neck or shoulder pain in last month	0.1	0.1	0.5	0.2	-0.1	-0.1	-0.0	0.7	-0.4	0.2
Medication: Blood pressure	0.9	1.7	3.3	-1.2	0.8	1.7	-0.7	-1.8	-1.6	-0.5
Angina (self-reported)	1.2	1.5	6.5	-1.8	0.2	-0.7	-0.2	-2.5	-0.7	0.5
Migraine (self-reported)	0.8	1.0	2.9	0.2	1.7	0.8	-0.5	0.9	-1.0	-1.1
Medication: Ibuprofen	1.0	1.2	3.0	1.1	1.3	1.7	0.8	1.2	-0.5	-0.3
Medication: Allopurinol	0.6	0.9	1.5	-1.0	0.6	-0.9	-1.2	-1.1	0.6	0.9
Medication: Omeprazole	1.0	1.2	2.6	-1.6	1.0	0.6	-0.8	-1.2	1.5	0.5
Medication: Seretide 50 evohaler	0.9	1.0	2.4	-1.3	0.1	0.5	-1.1	-1.5	1.1	0.4
Mean time to correctly identify matches	0.5	0.9	2.0	-0.1	0.8	0.6	1.4	0.8	-1.4	-0.9
Heart disease (mother)	2.0	2.4	6.7	-2.6	0.7	-0.3	-1.9	-2.4	0.3	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.3	0.2	1.8	0.5	1.1	1.7	-1.1	-1.0
Whole body fat mass	1.2	4.9	11.0	-3.3	1.6	0.6	-3.1	-3.0	0.4	1.1
Leg fat mass (right)	1.0	3.8	10.0	-3.2	1.1	0.2	-2.6	-2.8	0.3	1.1
Arm predicted mass (right)	0.1	0.3	0.8	0.9	0.3	0.1	-0.0	0.8	-0.1	0.7
Pulse rate, automated reading	0.5	1.8	5.7	-1.7	1.1	1.0	-0.8	-1.0	-2.4	-0.1
Alcohol intake frequency.	0.1	0.3	1.2	-0.1	-0.7	-1.1	-0.1	0.2	-0.1	-0.2
Comparative height size at age 10	0.4	1.9	5.0	1.9	0.5	0.6	1.3	2.2	-1.3	1.0
Number of full sisters	1.1	1.4	4.3	0.6	-1.9	-2.1	0.4	0.5	0.8	0.6
Suffer from ‘nerves’	1.0	1.6	3.2	-1.5	1.4	1.0	-1.8	-1.1	1.4	-0.1
Overall health rating	0.5	1.1	3.0	-1.7	0.3	-0.9	-1.0	-1.6	0.6	0.3
Chest pain or discomfort	0.6	0.9	2.2	-1.3	0.3	0.8	-1.5	-0.9	0.5	0.6
Had major operations	1.0	1.2	2.0	-0.9	1.3	1.2	-1.2	0.3	1.4	-0.9
Age at last live birth	0.1	0.2	0.7	0.3	-0.3	0.0	0.8	0.4	-0.3	-0.0
Family relationship satisfaction	0.6	0.7	2.4	-0.5	0.4	-0.5	-1.5	-0.6	-1.1	0.8
Leg pain on walking	0.5	0.7	1.1	-0.7	-0.9	-0.6	-1.0	-1.0	-0.1	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.9	-0.7	-0.0	-0.2	-0.6	-0.5	1.4	-0.8
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.1	-1.6	-0.4	-0.6	-0.7	-1.8	-0.7	0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	-0.6	0.8	0.2	-0.5	0.4	0.6	-0.3
Medication: Aspirin	1.5	1.9	3.3	-1.8	0.6	0.1	-1.7	-1.4	-1.4	1.7
Supplements: Vitamin C	2.1	2.4	6.6	1.7	-1.5	-1.9	0.7	1.1	-2.6	0.1
Knee pain experienced in last month	0.3	0.5	2.2	0.2	0.3	1.5	0.1	0.4	0.0	-1.0
Hypertension (Self-reported)	0.8	2.2	8.2	-2.5	0.2	0.5	-0.7	-2.9	-0.0	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.8	-1.4	0.6	0.0	-1.0	-1.1	0.0	-1.7
Illnesses of father: Heart disease	4.3	6.0	14.5	-2.0	-0.8	-1.4	-3.8	-3.5	1.6	2.4
Illnesses of siblings: Diabetes	1.6	2.0	4.4	-0.3	-2.0	-1.9	-0.1	-1.3	2.1	-0.3
Smoking status: Previous	3.8	5.8	12.2	-3.5	0.3	-0.3	-2.9	-3.3	-0.4	2.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	4.0	1.5	0.4	0.6	-0.1	2.0	-0.8	0.2
Whole body fat-free mass	0.1	0.6	1.5	0.9	0.6	0.2	-0.3	1.2	-0.3	1.2
Leg fat-free mass (right)	0.1	0.4	0.9	0.2	0.8	0.0	-0.6	0.8	-0.3	0.9
Arm fat percentage (left)	1.5	5.9	15.9	-4.0	1.4	0.5	-3.0	-3.6	0.8	-0.3
Average weekly red wine intake	0.4	0.6	0.8	0.7	0.2	0.9	0.9	0.8	-0.8	-0.7
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.5	-0.4	1.2	0.9	-0.1	-0.3	-1.3	1.6
Mood swings	1.7	3.0	4.6	-2.0	-1.9	-2.1	-2.1	-2.1	0.5	0.4
Loneliness, isolation	3.0	4.1	10.1	-2.4	-0.6	-0.6	-2.8	-3.2	1.0	1.9
Long-standing illness, disability or infirmity	0.2	0.4	1.1	-0.7	0.4	0.6	-0.0	-0.2	-1.0	-0.6
Ever had bowel cancer screening	0.9	1.1	2.2	-0.8	1.0	1.1	0.3	-1.5	-0.7	-1.3
Diabetes diagnosed by doctor	1.3	2.1	4.5	-2.1	1.6	2.1	-0.6	-1.4	-0.8	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.2	-0.6	-1.4	-1.7	-1.8	-0.7	0.1	0.8
Friendships satisfaction	0.5	0.6	1.9	0.2	1.4	0.7	-0.5	0.4	0.0	1.2
Qualifications: nursing, teaching	1.3	2.0	7.1	1.5	-2.7	-2.2	0.3	0.1	-0.4	0.2
Commuting to job workplace: Walk	1.8	1.9	5.3	2.0	-0.7	-0.1	1.0	1.7	0.1	-2.3
Eye problems/disorders: Cataract	0.9	1.0	3.5	0.6	-1.1	-0.8	0.7	0.2	-1.9	1.0
Mouth/teeth dental problems: Mouth ulcers	3.3	5.3	13.2	3.6	-0.9	-1.0	2.9	3.3	-1.6	-0.4
Medication for cholesterol	0.3	0.5	2.1	0.3	-0.1	0.3	0.4	0.4	-0.9	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.9	-0.6	0.7	0.9	-1.7	-0.4	0.3	1.5
Back pain experienced in last month	1.2	1.7	7.7	0.8	0.3	0.8	-0.5	0.5	-1.5	-2.8
Mineral and other dietary supplements	0.1	0.1	0.2	-0.4	-0.5	-0.3	-0.1	-0.4	0.3	-0.4
Breast cancer (self-reported)	0.7	0.8	1.9	0.4	-0.9	-0.6	1.4	0.5	-0.8	-1.3
Asthma (self-reported)	4.6	9.1	27.9	-3.9	0.8	0.3	-5.3	-3.5	0.4	2.8
Osteoporosis (self-reported)	1.0	1.2	2.7	1.3	0.0	0.6	1.1	1.7	-0.8	-1.5
Osteoarthritis (self-reported)	0.3	0.3	1.3	0.4	0.6	1.2	-0.2	0.4	0.3	0.5
Medication: Aspirin	1.1	1.5	3.3	-1.8	0.4	0.0	-1.5	-1.4	-1.3	1.1
Medication: Gliclazide	1.6	1.9	7.4	-0.9	1.9	2.7	0.2	-0.1	-0.8	-0.7
Illnesses of father: None of the above (group 1)	1.3	1.6	6.4	1.4	0.5	1.0	1.2	2.5	-0.1	-0.1
Smoking status: Current	0.3	0.5	1.3	-0.5	-0.9	-1.1	-0.7	-0.7	0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.6	7.3	2.3	0.2	0.5	1.9	2.7	-1.1	-0.9
Whole body water mass	0.1	0.6	1.5	0.8	0.6	0.2	-0.3	1.2	-0.3	1.2
Leg predicted mass (right)	0.1	0.4	0.9	0.2	0.8	0.0	-0.5	0.8	-0.3	1.0
Arm fat mass (left)	1.0	4.2	10.9	-3.3	1.4	0.5	-3.0	-2.8	0.3	0.4
Number of self-reported non-cancer illnesses	1.1	1.9	5.3	-1.3	1.9	2.3	-1.1	-0.6	-1.0	0.1
Average weekly champagne plus white wine intake	0.7	1.0	3.1	1.5	0.0	-1.0	0.6	1.8	-0.3	-0.3
Miserableness	1.5	2.5	4.8	-2.0	-1.1	-1.7	-1.9	-2.2	0.0	1.0
Guilty feelings	1.6	2.4	7.1	-0.5	-1.9	-0.7	-2.7	-0.9	0.3	2.1
Wears glasses or contact lenses	1.8	2.1	6.2	-1.5	2.5	2.1	-0.8	-0.0	-1.0	-0.1
Ever taken oral contraceptive pill	1.5	1.7	6.5	1.0	-2.5	-1.5	1.0	0.6	0.1	-0.9
Hearing aid user	0.7	0.8	4.5	0.0	-0.7	0.0	-2.1	0.1	0.8	0.5
Mother’s age at death	1.2	1.5	3.1	-0.8	1.0	1.1	-1.7	-0.5	-1.8	-1.0
Financial situation satisfaction	0.7	0.9	2.8	0.1	-1.7	-1.0	-1.1	-0.4	1.0	-0.3
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.7	1.1	0.0	-0.1	0.3	1.3	-1.6	-0.9
Commuting to job workplace: Public transport	1.2	1.5	4.2	1.5	0.2	0.7	0.9	1.3	2.1	-0.8
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	-1.0	0.3	0.5	0.2	-0.8	0.4	1.0
Medication: Blood pressure	1.3	2.5	6.4	-2.5	1.3	0.6	-1.6	-2.3	1.0	-0.2
Pain type(s) experienced in last month: Hip pain	2.5	3.2	9.5	-2.0	1.1	0.4	-3.1	-2.2	-0.9	1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	0.5	-0.8	-1.1	-0.3	-0.3	0.8	0.8
High cholesterol (Self-reported)	0.8	1.4	5.9	-1.0	-1.1	-0.4	-0.2	-2.4	1.4	-0.2
Medication: Bendroflumethiazide	0.6	0.9	2.8	-0.6	0.7	1.7	-1.5	-0.6	0.5	0.3
Medication: Paracetamol	0.4	0.7	2.0	0.8	-0.8	-0.0	0.5	1.1	1.4	-0.0
Medication: Lisinopril	0.5	0.6	1.7	-1.3	0.7	0.5	-0.0	-0.8	-0.7	0.7
Medication: Atorvastatin	1.0	1.2	3.7	-1.9	-0.0	0.1	-1.6	-1.4	-0.4	0.3
Illnesses of father: High blood pressure	0.1	0.1	0.5	-0.5	0.7	0.1	-0.1	-0.1	0.5	0.1
Alcohol drinker status: Never	0.8	1.0	2.1	0.3	1.5	1.0	-0.4	0.8	-1.4	1.0
Ever smoked	2.1	3.7	6.9	-2.5	-0.7	-1.6	-2.3	-2.6	0.8	1.9
Basal metabolic rate	0.1	0.5	1.9	0.1	0.6	0.1	-0.9	0.5	-0.2	1.4
Leg fat percentage (left)	1.7	6.1	16.2	-4.0	1.0	-0.0	-2.9	-4.0	0.9	0.7
Arm fat-free mass (left)	0.1	0.4	1.5	0.1	0.5	0.0	-1.0	0.5	-0.2	1.2
Number of operations (self-reported)	0.4	0.6	2.9	0.2	0.0	0.1	-0.2	1.1	-0.3	-1.7
Average weekly beer plus cider intake	1.3	1.8	3.4	-1.0	-1.6	-1.5	-1.1	-1.5	0.8	1.9
Irritability	1.4	2.4	4.4	-1.6	-1.3	-2.1	-1.8	-1.8	0.7	1.2
Risk taking	1.4	2.0	3.6	1.7	-1.6	-1.5	0.9	1.3	-1.9	-0.6
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.2	0.8	1.2	1.6	0.6	1.8	0.6	-0.8
Fractured/broken bones in last 5 years	0.6	0.8	2.3	1.5	-0.3	0.6	0.6	0.6	1.1	-0.7
Age started oral contraceptive pill	0.6	0.7	1.5	0.9	-0.8	-1.0	0.3	0.8	-1.2	-0.4
Diastolic blood pressure, automated reading	0.4	1.1	3.2	-1.8	-0.2	0.6	-1.1	-1.2	-0.9	0.9
Ever depressed for a whole week	0.6	0.7	2.4	1.2	0.1	0.1	0.2	1.6	-1.1	-0.2
Unable to work because of sickness or disability	0.3	0.4	1.3	1.0	-1.1	-0.8	0.4	-0.0	0.3	-0.0
Commuting to job workplace: Cycle	0.6	0.7	1.6	0.8	-0.9	-0.8	0.3	0.9	1.3	-0.0
Myopia	0.8	1.1	2.0	0.9	0.4	-0.8	0.9	1.2	-1.4	-1.4
Vascular/heart problems diagnosed by doctor	1.0	2.6	11.3	2.6	-0.1	-0.4	0.6	3.4	-0.2	-0.2
Cholesterol lowering medication	1.2	1.7	4.9	-1.7	-0.2	-0.2	-0.9	-2.2	-0.9	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.6	-1.4	0.3	0.0	-1.0	-1.3	1.6	0.7
Pain experienced in last month	0.5	0.8	3.4	-0.2	-0.3	0.2	-0.2	-0.7	1.3	1.8
Supplements: Calcium	0.8	0.9	2.8	0.3	1.4	1.1	0.5	0.3	-1.7	-0.2
Basal cell carcinoma (self-reported)	0.8	0.9	2.2	0.5	-1.1	-1.2	1.5	0.3	0.5	-1.0
Heart attack/myocardial infarction (self-reported)	1.7	2.2	6.3	-2.5	1.4	0.7	-0.9	-2.4	0.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	4.9	-1.1	0.2	-1.6	-0.8	-1.2	2.2	0.2
Heart disease (siblings)	0.6	0.7	1.7	0.8	-0.1	-0.2	1.3	0.7	0.9	-1.2
Alcohol drinker status: Previous	0.2	0.3	0.7	0.5	-0.1	-0.2	0.8	0.7	0.2	-0.6
Pack years of smoking	0.7	1.0	2.0	-1.4	1.2	0.3	-0.8	-0.9	0.3	-1.2
Impedance of whole body	0.1	0.5	0.9	-0.8	0.5	0.4	-0.9	-0.9	-0.9	-0.2
Leg fat mass (left)	1.0	3.8	10.1	-3.2	1.2	0.3	-2.5	-2.8	0.3	0.9
Arm predicted mass (left)	0.1	0.6	2.3	-0.0	0.3	-0.1	-1.2	0.2	0.1	1.5