Hub : Traits :

Asthma

511 significantly associated models · 144 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 7686056 11137778 5 3 4.0e-09 3.2e-09 4.9e-01 99 ENO1 KIF1B RERE
2 1 151079317 152991060 3 3 2.9e-11 1.0e-12 1.0e+00 100 FLG LINGO4 S100A11
3 1 166702558 168182443 1 1 5.0e-13 2.4e-13 1.0e+00 100 CD247
4 1 202317696 203743653 1 1 9.1e-08 1.4e-09 1.3e-04 60 PPFIA4
5 2 99468341 101456989 1 1 7.6e-08 2.2e-08 6.4e-03 76 AFF3
6 2 101994731 104027106 5 4 1.8e-31 5.1e-51 3.1e-15 72 IL18R1 IL1R1 IL1RL2
7 2 241941773 243048760 9 3 3.2e-23 8.6e-24 3.2e-01 99 D2HGDH ING5
8 4 38097478 39643536 3 2 2.1e-13 2.1e-15 8.2e-02 95 TLR1 TLR6
9 4 122377715 123976639 1 1 1.2e-13 1.1e-14 1.2e-02 89 KIAA1109
10 5 108927715 111527482 5 9 2.8e-23 4.2e-38 2.5e-01 99 CAMK4 SLC25A46 TMEM232 TSLP WDR36
11 5 130588008 132900729 16 8 1.4e-23 7.4e-26 NaN NaN AC034220.3 KIF3A P4HA2-AS1 SLC22A5
12 5 140789933 142230251 1 1 1.6e-09 1.1e-09 7.2e-03 81 NDFIP1
13 5 156009720 157697754 2 1 4.0e-10 4.5e-09 1.9e-02 84 ADAM19
14 6 25266147 26682323 1 2 1.8e-07 4.0e-09 2.2e-04 61 TRIM38
15 6 34528785 35987507 2 1 2.4e-08 1.0e-09 6.6e-03 80 ZNF76
16 6 89941356 91704536 1 2 2.5e-16 2.0e-24 3.4e-06 79 BACH2
17 6 134905567 136516257 2 2 5.6e-14 3.3e-09 7.7e-01 100 AHI1
18 7 27171588 28918565 1 1 1.1e-08 2.2e-12 6.9e-06 59 JAZF1
19 10 74879374 76266883 1 1 1.5e-07 2.2e-05 2.1e-01 91 RP11-574K11.5
20 10 93657148 95110026 1 1 7.5e-08 1.8e-08 1.4e-02 81 KIF11
21 11 60839578 62346131 6 1 6.0e-10 3.3e-10 1.3e-01 94 FADS1
22 11 64845438 66919278 4 2 5.3e-09 3.0e-10 5.9e-05 59 CTD-3074O7.5 EFEMP2
23 11 75369353 77536441 3 2 1.4e-26 3.4e-45 1.3e-15 68 LRRC32 PRKRIR
24 11 110776537 112295421 1 1 1.3e-09 1.7e-10 1.0e+00 100 SIK2
25 12 5809999 6956462 1 1 3.3e-07 1.4e-07 7.5e-02 89 RP1-102E24.8
26 12 47407397 48825686 1 1 2.9e-07 6.0e-06 1.0e-02 68 RP1-197B17.3
27 12 55601472 58677299 8 4 2.6e-15 2.8e-25 3.0e-17 34 AC034102.1 KIF5A STAT6
28 12 70713655 72104017 1 1 1.6e-10 1.4e-10 1.0e+00 100 CTD-2021H9.1
29 12 120502726 122037099 1 1 9.2e-09 8.4e-08 6.8e-02 88 SPPL3
30 13 99047988 100728229 2 1 3.8e-14 2.2e-17 6.2e-07 66 UBAC2
31 15 66662107 68789191 4 3 2.2e-23 2.6e-37 7.1e-14 66 AAGAB SMAD3
32 16 10325245 12010444 5 2 1.1e-19 1.4e-26 1.7e-06 80 CLEC16A RP11-396B14.2
33 16 26518263 28065536 4 2 2.4e-13 2.6e-12 9.1e-04 78 CTD-3203P2.1 IL4R
34 17 36660684 39048774 22 7 3.4e-48 3.6e-48 NaN NaN CASC3 GSDMA GSDMB MED24 PGAP3 THRA
35 17 39559539 40930095 1 1 1.1e-07 7.3e-08 4.0e-02 86 DHX58
36 17 42442344 43570226 2 2 1.0e-08 1.1e-08 3.5e-02 86 CTD-2020K17.3 NMT1
37 17 46581184 48139500 2 1 2.9e-07 9.5e-16 5.2e-10 40 ZNF652
38 19 15771809 17268784 1 1 3.0e-07 9.0e-06 3.4e-03 56 EPS15L1
39 19 45585167 46994833 2 1 5.0e-09 5.0e-10 1.0e+00 100 DMWD
40 22 41071659 42685537 5 1 1.1e-07 1.1e-07 1.0e+00 100 PMM1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 6.28 17 11 33.3 -0.39 8.0e-02 AC034220.3 BACH2 DHX58 FADS1 GSDMA GSDMB KIAA1109 KIF11 KIF3A LRRC32 MED24 NDFIP1 P4HA2-AS1 PGAP3 RP11-574K11.5 SLC22A5 SMAD3
Irritable Bowel Disease (IBD) 5.46 18 14 42.4 -0.35 1.1e-01 AC034220.3 BACH2 CASC3 DHX58 GSDMA GSDMB KIAA1109 KIF11 KIF3A LRRC32 MED24 NDFIP1 P4HA2-AS1 PGAP3 PRKRIR RP11-574K11.5 SLC22A5 SMAD3
Ulcerative Colitis (UC) 2.81 10 3 9.1 -0.29 4.1e-01 CASC3 GSDMA GSDMB KIAA1109 LRRC32 MED24 P4HA2-AS1 PGAP3 PRKRIR SMAD3
Reaction Time 1.03 1 0 0.0 0.00 1.0e+00 AC034102.1
Verbal and Numeric Reasoning (VNR) 1.21 4 1 3.0 0.22 7.8e-01 AC034102.1 AFF3 FADS1 TRIM38
Breast Cancer 1.89 8 4 12.1 -0.67 4.6e-02 AC034220.3 EFEMP2 KIF1B P4HA2-AS1 SIK2 SLC22A5 TLR1 TLR6
Body Mass Index (BMI) (2010) 1.26 1 0 0.0 0.00 1.0e+00 SMAD3
Crohns Disease (2012) 4.89 9 5 15.2 0.52 8.1e-02 AC034220.3 FADS1 GSDMB LRRC32 NDFIP1 P4HA2-AS1 PGAP3 SLC22A5 SMAD3
Fasting Glucose 1.60 1 1 3.0 0.00 1.0e+00 FADS1
HDL Cholesterol 2.77 5 4 12.1 0.19 7.2e-01 FADS1 GSDMB KIF5A PGAP3 ZNF76
LDL Cholesterol 1.60 1 1 3.0 0.00 1.0e+00 FADS1
Lupus 2.00 1 0 0.0 0.00 1.0e+00 GSDMB
Primary Biliary Cirrhosis 2.05 2 1 3.0 0.00 1.0e+00 GSDMB PGAP3
Rheumatoid Arthritis 1.61 2 0 0.0 0.00 1.0e+00 GSDMB PGAP3
Schizophrenia 0.99 1 0 0.0 0.00 1.0e+00 RERE
Triglycerides 2.10 2 2 6.1 0.00 1.0e+00 FADS1 KIF5A
Type 2 Diabetes (T2D) 1.87 1 1 3.0 0.00 1.0e+00 KIF11
Ulcerative Colitis 2.38 3 0 0.0 0.00 1.0e+00 GSDMB P4HA2-AS1 PGAP3
Blood Eosinophil Count 21.14 45 41 124.2 -0.87 1.4e-18 AAGAB AC034102.1 AC034220.3 AHI1 BACH2 CAMK4 CASC3 CD247 CLEC16A CTD-3203P2.1 D2HGDH DMWD EFEMP2 FADS1 GSDMA GSDMB IL18R1 IL1R1 IL1RL2 IL4R ING5 KIAA1109 KIF11 KIF1B KIF3A LRRC32 MED24 NDFIP1 P4HA2-AS1 PMM1 PRKRIR RERE RP1-102E24.8 RP11-396B14.2 SIK2 SLC22A5 SLC25A46 SMAD3 SPPL3 STAT6 THRA TSLP UBAC2 WDR36 ZNF652
Blood Platelet Count 2.91 22 19 57.6 -0.37 5.9e-02 AC034220.3 CTD-2021H9.1 DMWD ENO1 FADS1 GSDMB ING5 KIAA1109 KIF1B KIF3A KIF5A NDFIP1 NMT1 P4HA2-AS1 PGAP3 PMM1 RP1-102E24.8 RP1-197B17.3 SIK2 SLC22A5 SPPL3 STAT6
Blood Red Count 1.21 12 6 18.2 -0.23 4.2e-01 AC034102.1 AFF3 AHI1 BACH2 CTD-3074O7.5 FADS1 GSDMB KIF11 KIF5A NDFIP1 PGAP3 SPPL3
Blood White Count 14.38 24 20 60.6 -0.67 5.1e-05 AC034220.3 AHI1 BACH2 CASC3 CLEC16A EFEMP2 ENO1 EPS15L1 FADS1 GSDMA GSDMB KIF1B KIF3A MED24 NDFIP1 P4HA2-AS1 PGAP3 RERE RP1-102E24.8 RP11-396B14.2 SLC22A5 SPPL3 THRA ZNF76
Heel T-Score 1.44 13 11 33.3 0.20 5.2e-01 AAGAB AC034102.1 BACH2 DHX58 DMWD ENO1 FADS1 JAZF1 KIF1B NMT1 PMM1 RERE ZNF76
BMI 0.83 7 2 6.1 0.55 2.0e-01 AAGAB AC034102.1 CAMK4 GSDMA MED24 SMAD3 TLR1
Height 2.37 24 16 48.5 0.51 4.3e-03 AAGAB AC034220.3 AFF3 AHI1 CTD-3074O7.5 DMWD FADS1 GSDMA JAZF1 KIAA1109 KIF11 KIF1B KIF3A NDFIP1 NMT1 P4HA2-AS1 RERE SLC22A5 SMAD3 SPPL3 STAT6 THRA ZNF652 ZNF76
Waist Hip Ratio (WHR) 1.24 10 2 6.1 0.04 9.1e-01 AAGAB AFF3 BACH2 DHX58 DMWD GSDMA MED24 RP11-396B14.2 SIK2 THRA
Systolic Blood Pressure 1.41 8 5 15.2 -0.47 2.5e-01 CTD-2020K17.3 DMWD ENO1 KIF11 NMT1 RERE SIK2 SMAD3
Smoking Status 1.52 5 2 6.1 -0.34 5.7e-01 AC034102.1 PGAP3 PMM1 RERE ZNF652
Allergy or Eczema 22.10 51 41 124.2 -0.91 4.5e-25 AAGAB AC034102.1 AHI1 BACH2 CAMK4 CASC3 CD247 CLEC16A CTD-2020K17.3 CTD-3203P2.1 D2HGDH DHX58 EFEMP2 ENO1 FLG GSDMA GSDMB IL18R1 IL1R1 IL1RL2 IL4R ING5 JAZF1 KIAA1109 KIF3A LINGO4 LRRC32 MED24 NDFIP1 NMT1 P4HA2-AS1 PGAP3 PMM1 PRKRIR RERE RP11-396B14.2 RP11-574K11.5 S100A11 SIK2 SLC22A5 SLC25A46 SMAD3 SPPL3 STAT6 THRA TLR1 TLR6 TMEM232 TSLP UBAC2 WDR36
Cardiovascular Disease 1.38 8 3 9.1 -0.55 1.6e-01 AAGAB AC034102.1 NMT1 P4HA2-AS1 RERE SIK2 SLC22A5 ZNF652
Hypothyroidism (self reported) 3.71 10 5 15.2 0.26 4.2e-01 AC034102.1 AHI1 BACH2 CD247 FADS1 PMM1 RERE SPPL3 TLR1 TLR6
Respiratory disease 25.68 64 56 169.7 -1.00 8.2e-79 AAGAB AC034102.1 AC034220.3 ADAM19 AHI1 BACH2 CAMK4 CASC3 CD247 CLEC16A CTD-2020K17.3 CTD-2021H9.1 CTD-3074O7.5 CTD-3203P2.1 D2HGDH DHX58 DMWD EFEMP2 ENO1 FADS1 FLG GSDMA GSDMB IL18R1 IL1R1 IL1RL2 IL4R ING5 JAZF1 KIAA1109 KIF11 KIF1B KIF3A KIF5A LINGO4 LRRC32 MED24 NDFIP1 NMT1 P4HA2-AS1 PGAP3 PMM1 PPFIA4 PRKRIR RERE RP11-396B14.2 RP11-574K11.5 RP1-197B17.3 S100A11 SIK2 SLC22A5 SLC25A46 SMAD3 SPPL3 STAT6 THRA TLR1 TLR6 TMEM232 TSLP UBAC2 WDR36 ZNF652 ZNF76
Type 2 Diabetes (T2D) 1.53 2 1 3.0 0.00 1.0e+00 KIF11 PGAP3
Lung FEV1/FVC ratio 4.09 20 14 42.4 0.79 5.5e-06 AC034102.1 AC034220.3 ADAM19 BACH2 D2HGDH DMWD GSDMB IL18R1 IL1RL2 MED24 P4HA2-AS1 RERE RP11-396B14.2 RP11-574K11.5 SLC22A5 SMAD3 STAT6 THRA ZNF652 ZNF76
Lung FVC 1.91 13 8 24.2 0.06 8.3e-01 AAGAB AC034102.1 AC034220.3 AHI1 CLEC16A GSDMB KIF1B LINGO4 P4HA2-AS1 PGAP3 RP11-574K11.5 SLC22A5 SPPL3
Neuroticism 1.20 4 0 0.0 0.66 3.4e-01 AAGAB AHI1 PMM1 RERE
Chronotype (morning person) 1.26 3 0 0.0 0.31 6.9e-01 KIAA1109 RERE WDR36
Hair Pigment 0.17 7 4 12.1 0.33 4.6e-01 AHI1 FADS1 JAZF1 KIF1B KIF5A RERE ZNF76
Tanning 0.17 2 0 0.0 0.00 1.0e+00 D2HGDH JAZF1
Hand grip strength (left) 2.45 6 4 12.1 -0.98 4.5e-06 AC034220.3 KIF1B KIF3A P4HA2-AS1 SLC22A5 ZNF76
Number of treatments/medications taken 2.50 3 0 0.0 1.00 1.0e-03 CLEC16A FADS1 P4HA2-AS1
Frequency of depressed mood in last 2 weeks 1.45 1 0 0.0 0.00 1.0e+00 RERE
Relative age of first facial hair 1.08 1 0 0.0 0.00 1.0e+00 SPPL3
Systolic blood pressure, automated reading 1.38 5 2 6.1 0.92 2.6e-02 DMWD ENO1 KIF11 NMT1 RERE
Vitamin and mineral supplements 1.40 1 0 0.0 0.00 1.0e+00 STAT6
Medication: Metformin 1.33 1 0 0.0 0.00 1.0e+00 KIF11
Impedance of leg (right) 0.97 5 3 9.1 0.73 1.7e-01 AC034102.1 JAZF1 KIF1B S100A11 ZNF652
Leg fat-free mass (left) 1.60 7 4 12.1 -0.81 2.5e-03 AC034102.1 AC034220.3 P4HA2-AS1 SLC22A5 SMAD3 TRIM38 ZNF76
Trunk fat percentage 1.19 6 4 12.1 0.98 8.3e-04 AAGAB FLG PMM1 RERE SMAD3 TRIM38
Hand grip strength (right) 2.66 7 4 12.1 -0.97 4.0e-07 AC034220.3 KIF1B KIF3A P4HA2-AS1 SLC22A5 STAT6 ZNF76
Current tobacco smoking 1.40 1 0 0.0 0.00 1.0e+00 PMM1
Maternal smoking around birth 1.18 1 0 0.0 0.00 1.0e+00 PMM1
Taking other prescription medications 3.91 6 0 0.0 0.95 3.1e-03 AHI1 CTD-3074O7.5 D2HGDH GSDMA GSDMB IL1RL2
Age when periods started (menarche) 1.56 3 0 0.0 0.00 1.0e+00 AAGAB NMT1 SPPL3
Heel bone mineral density (BMD) T-score, automated (left) 1.18 4 1 3.0 -0.99 5.1e-03 DHX58 FADS1 RERE ZNF76
High blood pressure 1.78 9 4 12.1 0.69 1.3e-02 AAGAB AC034102.1 AC034220.3 NMT1 P4HA2-AS1 RERE SIK2 SLC22A5 ZNF652
Hayfever, allergic rhinitis or eczema 19.65 44 37 112.1 0.93 1.5e-24 AC034102.1 AHI1 BACH2 CAMK4 CD247 CLEC16A CTD-3203P2.1 D2HGDH DHX58 EFEMP2 ENO1 FLG GSDMA GSDMB IL18R1 IL1R1 IL1RL2 IL4R JAZF1 KIAA1109 KIF3A LINGO4 LRRC32 MED24 NDFIP1 P4HA2-AS1 PGAP3 PMM1 PRKRIR RERE RP11-396B14.2 S100A11 SIK2 SLC22A5 SLC25A46 SMAD3 SPPL3 STAT6 THRA TLR1 TLR6 TMEM232 TSLP WDR36
Supplements: Glucosamine 1.12 1 0 0.0 0.00 1.0e+00 NMT1
Medication: Levothyroxine sodium 3.20 6 2 6.1 -0.24 6.0e-01 AC034102.1 AHI1 BACH2 CD247 FADS1 RERE
Sitting height 1.63 9 6 18.2 -0.67 1.2e-02 AC034220.3 DMWD FADS1 KIAA1109 P4HA2-AS1 SLC22A5 STAT6 TRIM38 ZNF76
Chronic bronchitis/emphysema (father) 1.57 1 0 0.0 0.00 1.0e+00 KIF1B
Body mass index (BMI) 0.87 5 1 3.0 0.16 8.0e-01 AC034102.1 GSDMA RERE SMAD3 TRIM38
Impedance of leg (left) 1.03 6 3 9.1 0.72 1.1e-01 AC034102.1 JAZF1 KIF1B S100A11 SLC22A5 ZNF652
Leg predicted mass (left) 1.60 8 4 12.1 -0.82 1.2e-03 AC034102.1 AC034220.3 P4HA2-AS1 SLC22A5 SMAD3 STAT6 TRIM38 ZNF76
Trunk fat mass 1.13 6 2 6.1 0.98 6.3e-04 AAGAB FLG PMM1 RERE SMAD3 TRIM38
Waist circumference 0.97 4 2 6.1 -0.31 6.9e-01 AAGAB AC034102.1 DHX58 SMAD3
Past tobacco smoking 1.47 3 0 0.0 0.00 1.0e+00 AAGAB PGAP3 ZNF652
Nervous feelings 0.87 1 0 0.0 0.00 1.0e+00 AAGAB
Hair/balding pattern: Pattern 2 1.53 1 0 0.0 0.00 1.0e+00 NMT1
Forced vital capacity (FVC) 1.25 8 3 9.1 -0.50 1.7e-01 AAGAB AHI1 CTD-3074O7.5 DMWD LINGO4 RP11-574K11.5 TRIM38 ZNF76
Heel bone mineral density (BMD) T-score, automated (right) 1.40 5 2 6.1 -1.00 3.8e-04 DHX58 ENO1 FADS1 RERE ZNF76
Qualifications: None of the above 1.12 3 1 3.0 0.00 1.0e+00 AC034102.1 AFF3 TRIM38
Heart attack 1.32 1 0 0.0 0.00 1.0e+00 KIF5A
Allergy 25.39 60 49 148.5 -0.96 2.3e-43 AAGAB AC034102.1 AC034220.3 AHI1 BACH2 CAMK4 CASC3 CD247 CLEC16A CTD-2020K17.3 CTD-3074O7.5 CTD-3203P2.1 D2HGDH DHX58 EFEMP2 ENO1 EPS15L1 FADS1 FLG GSDMA GSDMB IL18R1 IL1R1 IL1RL2 IL4R ING5 JAZF1 KIAA1109 KIF11 KIF1B KIF3A KIF5A LINGO4 LRRC32 MED24 NDFIP1 NMT1 P4HA2-AS1 PGAP3 PMM1 PRKRIR RERE RP11-396B14.2 RP11-574K11.5 S100A11 SIK2 SLC22A5 SLC25A46 SMAD3 SPPL3 STAT6 THRA TLR1 TLR6 TMEM232 TRIM38 TSLP UBAC2 WDR36 ZNF652
Diabetes (self-reported) 1.38 1 1 3.0 0.00 1.0e+00 KIF11
Hayfever/allergic rhinitis (self-reported) 9.89 19 13 39.4 0.96 2.6e-14 AC034102.1 BACH2 CAMK4 CD247 CLEC16A D2HGDH GSDMB IL18R1 IL1RL2 KIAA1109 LRRC32 RP11-396B14.2 SLC25A46 SMAD3 TLR1 TLR6 TMEM232 TSLP WDR36
Medication: Simvastatin 1.46 1 0 0.0 0.00 1.0e+00 DMWD
Fluid intelligence score 1.29 2 0 0.0 0.00 1.0e+00 AC034102.1 AFF3
Neuroticism score 1.17 2 0 0.0 0.00 1.0e+00 PMM1 RERE
Weight 1.25 9 5 15.2 -0.58 3.7e-02 AAGAB AC034102.1 AC034220.3 FLG P4HA2-AS1 SLC22A5 SMAD3 TRIM38 ZNF76
Impedance of arm (right) 1.37 12 6 18.2 0.81 1.2e-03 AAGAB AC034102.1 GSDMA JAZF1 KIF1B LRRC32 MED24 NDFIP1 PMM1 SMAD3 THRA ZNF652
Arm fat percentage (right) 1.12 5 3 9.1 1.00 4.1e-04 AAGAB CTD-3074O7.5 PMM1 RERE SMAD3
Trunk fat-free mass 1.74 8 7 21.2 -0.98 4.0e-08 AC034102.1 AC034220.3 NMT1 P4HA2-AS1 SLC22A5 STAT6 TRIM38 ZNF76
Hip circumference 0.90 5 1 3.0 -0.59 2.2e-01 AC034102.1 GSDMA MED24 SMAD3 TRIM38
Father's age at death 1.98 2 0 0.0 0.00 1.0e+00 P4HA2-AS1 SLC22A5
Frequency of tiredness / lethargy in last 2 weeks 1.28 2 0 0.0 0.00 1.0e+00 RERE RP11-574K11.5
Hair/balding pattern: Pattern 3 1.16 1 0 0.0 0.00 1.0e+00 AC034220.3
Number of live births 1.14 1 1 3.0 0.00 1.0e+00 FADS1
Forced expiratory volume in 1-second (FEV1) 2.07 11 6 18.2 -0.92 1.8e-05 AC034102.1 ADAM19 AHI1 CTD-3074O7.5 LINGO4 P4HA2-AS1 PGAP3 RP11-574K11.5 SLC22A5 TRIM38 ZNF76
Pulse rate 1.29 1 1 3.0 0.00 1.0e+00 FADS1
Qualifications: A levels/AS levels or equivalent 0.83 2 0 0.0 0.00 1.0e+00 AC034102.1 TRIM38
Mouth/teeth dental problems: Dentures 1.11 2 0 0.0 0.00 1.0e+00 PGAP3 TRIM38
Medication: Ibuprofen (e.g. Nurofen) 1.39 1 1 3.0 0.00 1.0e+00 STAT6
Depression (self-reported) 1.45 1 0 0.0 0.00 1.0e+00 RERE
Prospective memory result 1.07 1 0 0.0 0.00 1.0e+00 TRIM38
Forced expiratory volume in 1-second (FEV1), Best measure 2.12 10 6 18.2 -0.94 7.1e-06 AC034102.1 ADAM19 AHI1 LINGO4 P4HA2-AS1 RERE RP11-574K11.5 SLC22A5 TRIM38 ZNF76
Impedance of arm (left) 1.32 11 4 12.1 0.79 4.1e-03 AAGAB AC034102.1 CTD-2020K17.3 GSDMA JAZF1 KIF1B LRRC32 MED24 PMM1 SMAD3 ZNF652
Arm fat mass (right) 0.96 5 3 9.1 0.42 4.9e-01 AAGAB AC034102.1 RERE SMAD3 TRIM38
Trunk predicted mass 1.74 8 7 21.2 -0.98 3.8e-08 AC034102.1 AC034220.3 NMT1 P4HA2-AS1 SLC22A5 STAT6 TRIM38 ZNF76
Standing height 2.47 15 11 33.3 -0.69 1.2e-03 AAGAB AC034220.3 DMWD FADS1 KIAA1109 KIF11 KIF3A NMT1 P4HA2-AS1 RERE SLC22A5 SPPL3 STAT6 TRIM38 ZNF76
Tense / 'highly strung' 1.26 2 0 0.0 0.00 1.0e+00 PMM1 RERE
Seen doctor (GP) for nerves, anxiety, tension or depression 1.29 1 0 0.0 0.00 1.0e+00 CTD-3074O7.5
Hair/balding pattern: Pattern 4 1.64 5 1 3.0 0.56 3.3e-01 CTD-2020K17.3 FADS1 KIF1B RERE S100A11
Birth weight of first child 1.56 1 0 0.0 0.00 1.0e+00 AC034102.1
Peak expiratory flow (PEF) 1.46 3 1 3.0 0.00 1.0e+00 ADAM19 SLC22A5 ZNF76
Medication: Paracetamol 1.33 1 0 0.0 0.00 1.0e+00 STAT6
Headache pain in last month 2.05 3 2 6.1 0.00 1.0e+00 AC034102.1 DMWD STAT6
Medication for cholesterol, blood pressure or diabetes 1.16 1 1 3.0 0.00 1.0e+00 SIK2
Gout (self-reported) 1.69 1 1 3.0 0.00 1.0e+00 KIF5A
Hypothyroidism/myxoedema (self-reported) 3.51 6 3 9.1 -0.21 6.2e-01 AC034102.1 AHI1 BACH2 CD247 FADS1 RERE
Medication: Ventolin 100micrograms inhaler 10.64 26 5 15.2 0.99 2.5e-22 AAGAB AC034102.1 AHI1 BACH2 CD247 CLEC16A CTD-2020K17.3 CTD-3203P2.1 D2HGDH GSDMB IL18R1 IL1RL2 ING5 KIAA1109 LRRC32 NDFIP1 PGAP3 PMM1 PRKRIR SLC22A5 SLC25A46 SMAD3 STAT6 THRA TLR1 TSLP
Birth weight 1.46 2 2 6.1 0.00 1.0e+00 KIF11 SIK2
Forced vital capacity (FVC), Best measure 1.25 8 3 9.1 -0.74 2.1e-02 AAGAB AC034102.1 AHI1 CTD-3074O7.5 LINGO4 RP11-574K11.5 TRIM38 ZNF76
Body fat percentage 1.17 7 3 9.1 0.98 5.3e-05 AAGAB FLG NMT1 PMM1 RERE SMAD3 TRIM38
Leg fat percentage (right) 1.24 5 3 9.1 0.99 5.6e-04 AAGAB NMT1 RERE SMAD3 TRIM38
Arm fat-free mass (right) 1.56 8 6 18.2 -0.99 1.8e-08 AC034102.1 AC034220.3 NMT1 P4HA2-AS1 SLC22A5 STAT6 TRIM38 ZNF76
Comparative body size at age 10 1.26 2 0 0.0 0.00 1.0e+00 SMAD3 ZNF652
Worry too long after embarrassment 1.14 1 0 0.0 0.00 1.0e+00 AHI1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.39 1 0 0.0 0.00 1.0e+00 TRIM38
Wheeze or whistling in the chest in last year 9.25 36 15 45.5 0.98 1.2e-30 AAGAB ADAM19 AFF3 BACH2 CAMK4 CASC3 CD247 CLEC16A D2HGDH DHX58 DMWD FADS1 GSDMA GSDMB IL18R1 IL1R1 IL1RL2 ING5 KIAA1109 LRRC32 MED24 NMT1 PGAP3 PRKRIR RERE RP11-396B14.2 RP11-574K11.5 SIK2 SLC22A5 SLC25A46 SMAD3 STAT6 THRA TSLP UBAC2 WDR36
Age at first live birth 1.09 1 0 0.0 0.00 1.0e+00 AC034102.1
Shortness of breath walking on level ground 1.55 1 0 0.0 0.00 1.0e+00 LRRC32
Qualifications: College or University degree 1.14 3 3 9.1 0.00 1.0e+00 AC034102.1 AFF3 TRIM38
Medication for pain relief, constipation, heartburn 1.25 1 1 3.0 0.00 1.0e+00 STAT6
Neck or shoulder pain in last month 0.96 1 0 0.0 0.00 1.0e+00 RERE
Medication: Blood pressure 1.37 1 1 3.0 0.00 1.0e+00 SIK2
Migraine (self-reported) 1.82 1 1 3.0 0.00 1.0e+00 STAT6
Medication: Ibuprofen 1.30 1 1 3.0 0.00 1.0e+00 STAT6
Medication: Allopurinol 1.46 1 1 3.0 0.00 1.0e+00 KIF5A
Medication: Seretide 50 evohaler 6.12 6 0 0.0 0.99 1.8e-09 BACH2 D2HGDH IL18R1 P4HA2-AS1 SLC22A5 SMAD3
Whole body fat mass 1.03 7 3 9.1 0.52 2.3e-01 AAGAB AC034102.1 FLG PMM1 RERE SMAD3 TRIM38
Leg fat mass (right) 0.97 5 4 12.1 0.51 3.8e-01 AAGAB AC034102.1 RERE SMAD3 TRIM38
Arm predicted mass (right) 1.57 9 6 18.2 -0.98 6.6e-08 AC034102.1 AC034220.3 MED24 NMT1 P4HA2-AS1 SLC22A5 STAT6 TRIM38 ZNF76
Pulse rate, automated reading 1.49 4 1 3.0 -0.13 8.7e-01 AC034102.1 FADS1 PGAP3 SIK2
Alcohol intake frequency. 1.06 3 0 0.0 0.00 1.0e+00 AC034102.1 AFF3 STAT6
Comparative height size at age 10 2.12 10 7 21.2 -0.72 5.4e-03 AAGAB AC034220.3 DMWD KIF11 P4HA2-AS1 RERE SLC22A5 SMAD3 TRIM38 ZNF76
Suffer from 'nerves' 1.23 1 0 0.0 0.00 1.0e+00 RERE
Overall health rating 0.96 1 0 0.0 0.00 1.0e+00 CTD-3074O7.5
Medication: Aspirin 1.31 1 0 0.0 0.00 1.0e+00 SIK2
Supplements: Vitamin C 1.19 1 0 0.0 0.00 1.0e+00 GSDMB
Knee pain experienced in last month 1.06 1 0 0.0 0.00 1.0e+00 RP11-396B14.2
Hypertension (Self-reported) 1.78 8 4 12.1 0.66 2.8e-02 AC034102.1 AC034220.3 NMT1 P4HA2-AS1 RERE SIK2 SLC22A5 ZNF652
Illnesses of father: Heart disease 1.65 2 0 0.0 0.00 1.0e+00 SIK2 SMAD3
Smoking status: Previous 1.38 1 0 0.0 0.00 1.0e+00 AC034102.1
Forced expiratory volume in 1-second (FEV1), predicted 1.93 5 4 12.1 -0.84 8.9e-03 AC034220.3 FADS1 P4HA2-AS1 SLC22A5 ZNF76
Whole body fat-free mass 1.67 8 7 21.2 -0.99 3.3e-08 AC034102.1 AC034220.3 NMT1 P4HA2-AS1 SLC22A5 STAT6 TRIM38 ZNF76
Leg fat-free mass (right) 1.55 7 4 12.1 -0.98 6.4e-07 AC034102.1 AC034220.3 P4HA2-AS1 SLC22A5 STAT6 TRIM38 ZNF76
Arm fat percentage (left) 1.09 6 3 9.1 0.99 6.0e-05 AAGAB CTD-3074O7.5 PMM1 RERE SMAD3 TRIM38
Mood swings 0.86 1 0 0.0 0.00 1.0e+00 PMM1
Loneliness, isolation 1.06 1 0 0.0 0.00 1.0e+00 RERE
Long-standing illness, disability or infirmity 2.10 1 0 0.0 0.00 1.0e+00 NMT1
Ever had bowel cancer screening 1.20 1 0 0.0 0.00 1.0e+00 SIK2
Diabetes diagnosed by doctor 1.47 1 1 3.0 0.00 1.0e+00 KIF11
Friendships satisfaction 1.01 1 0 0.0 0.00 1.0e+00 EFEMP2
Mineral and other dietary supplements 1.62 1 0 0.0 0.00 1.0e+00 NMT1
Asthma (self-reported) 26.46 68 65 197.0 1.00 2.5e-131 AAGAB AC034102.1 AC034220.3 ADAM19 AFF3 AHI1 BACH2 CAMK4 CASC3 CD247 CLEC16A CTD-2020K17.3 CTD-2021H9.1 CTD-3074O7.5 CTD-3203P2.1 D2HGDH DHX58 DMWD EFEMP2 ENO1 EPS15L1 FADS1 FLG GSDMA GSDMB IL18R1 IL1R1 IL1RL2 IL4R ING5 JAZF1 KIAA1109 KIF11 KIF1B KIF3A KIF5A LINGO4 LRRC32 MED24 NDFIP1 NMT1 P4HA2-AS1 PGAP3 PMM1 PPFIA4 PRKRIR RERE RP1-102E24.8 RP11-396B14.2 RP11-574K11.5 RP1-197B17.3 S100A11 SIK2 SLC22A5 SLC25A46 SMAD3 SPPL3 STAT6 THRA TLR1 TLR6 TMEM232 TRIM38 TSLP UBAC2 WDR36 ZNF652 ZNF76
Medication: Aspirin 1.23 1 0 0.0 0.00 1.0e+00 SIK2
Illnesses of father: None of the above (group 1) 1.33 1 0 0.0 0.00 1.0e+00 SMAD3
Smoking status: Current 1.34 1 0 0.0 0.00 1.0e+00 PMM1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.15 5 2 6.1 -0.93 2.1e-02 AC034102.1 ADAM19 GSDMB PGAP3 TRIM38
Whole body water mass 1.69 8 7 21.2 -0.98 3.7e-08 AC034102.1 AC034220.3 NMT1 P4HA2-AS1 SLC22A5 STAT6 TRIM38 ZNF76
Leg predicted mass (right) 1.56 7 4 12.1 -0.98 6.7e-07 AC034102.1 AC034220.3 P4HA2-AS1 SLC22A5 STAT6 TRIM38 ZNF76
Arm fat mass (left) 0.95 5 3 9.1 0.45 4.5e-01 AAGAB AC034102.1 RERE SMAD3 TRIM38
Number of self-reported non-cancer illnesses 4.45 11 3 9.1 0.98 1.3e-08 AAGAB D2HGDH GSDMB IL1RL2 KIF3A LRRC32 P4HA2-AS1 PPFIA4 RP11-396B14.2 SLC22A5 ZNF652
Average weekly champagne plus white wine intake 1.17 1 0 0.0 0.00 1.0e+00 FADS1
Miserableness 1.34 1 0 0.0 0.00 1.0e+00 RERE
Medication: Blood pressure 2.08 6 1 3.0 0.81 1.5e-02 AC034220.3 KIF3A NMT1 P4HA2-AS1 SIK2 SLC22A5
Supplements: Fish oil (including cod liver oil) 1.71 1 0 0.0 0.00 1.0e+00 NMT1
High cholesterol (Self-reported) 1.32 1 0 0.0 0.00 1.0e+00 FADS1
Medication: Bendroflumethiazide 2.03 3 0 0.0 0.98 4.4e-03 AC034220.3 P4HA2-AS1 SLC22A5
Medication: Paracetamol 1.11 1 0 0.0 0.00 1.0e+00 NMT1
Ever smoked 1.23 1 0 0.0 0.00 1.0e+00 PGAP3
Basal metabolic rate 1.58 7 6 18.2 -0.98 2.2e-07 AC034102.1 AC034220.3 P4HA2-AS1 SLC22A5 STAT6 TRIM38 ZNF76
Leg fat percentage (left) 1.28 6 1 3.0 0.61 2.0e-01 AAGAB GSDMA NMT1 RERE SMAD3 TRIM38
Arm fat-free mass (left) 1.56 7 6 18.2 -0.99 8.5e-08 AC034102.1 AC034220.3 P4HA2-AS1 SLC22A5 STAT6 TRIM38 ZNF76
Average weekly beer plus cider intake 1.51 1 0 0.0 0.00 1.0e+00 STAT6
Irritability 1.02 2 0 0.0 0.00 1.0e+00 FADS1 PMM1
Fractured/broken bones in last 5 years 1.33 1 0 0.0 0.00 1.0e+00 AAGAB
Age started oral contraceptive pill 0.88 1 0 0.0 0.00 1.0e+00 AC034102.1
Diastolic blood pressure, automated reading 1.69 5 2 6.1 0.99 2.5e-04 AAGAB AC034220.3 NMT1 P4HA2-AS1 RERE
Myopia 1.61 2 0 0.0 0.00 1.0e+00 GSDMB STAT6
Vascular/heart problems diagnosed by doctor 1.91 9 6 18.2 -0.66 1.9e-02 AAGAB AC034220.3 NMT1 P4HA2-AS1 RERE SIK2 SLC22A5 SMAD3 ZNF652
Pain experienced in last month 1.24 1 0 0.0 0.00 1.0e+00 AC034102.1
Basal cell carcinoma (self-reported) 1.52 1 0 0.0 0.00 1.0e+00 PMM1
Heart attack/myocardial infarction (self-reported) 1.40 1 0 0.0 0.00 1.0e+00 KIF5A
Impedance of whole body 1.12 6 5 15.2 0.70 1.2e-01 AC034102.1 JAZF1 KIF1B LRRC32 PMM1 ZNF652
Leg fat mass (left) 0.97 7 5 15.2 0.27 5.6e-01 AAGAB AC034102.1 FLG GSDMA RERE SMAD3 TRIM38
Arm predicted mass (left) 1.59 7 6 18.2 -0.99 1.4e-07 AC034102.1 AC034220.3 P4HA2-AS1 SLC22A5 STAT6 TRIM38 ZNF76

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 9 0.2578 1.92
GTEx Adipose Visceral Omentum 9 0.4420 2.01
GTEx Adrenal Gland 5 0.3432 1.81
GTEx Artery Aorta 14 0.4703 1.96
GTEx Artery Coronary 1 0.0845 1.71
GTEx Artery Tibial 20 0.5318 2.03
GTEx Brain Caudate basal ganglia 3 0.3261 1.75
GTEx Brain Cerebellar Hemisphere 4 0.2686 1.96
GTEx Brain Cerebellum 6 0.3027 1.95
GTEx Brain Cortex 7 0.6763 2.04
GTEx Brain Frontal Cortex BA9 5 0.5411 2.02
GTEx Brain Hippocampus 2 0.3817 1.74
GTEx Brain Hypothalamus 2 0.3390 2.00
GTEx Brain Nucleus accumbens basal ganglia 6 0.6936 2.15
GTEx Brain Putamen basal ganglia 4 0.6410 2.05
GTEx Breast Mammary Tissue 10 0.5066 2.04
GTEx Breast Mammary Tissue (Male) 6 0.5029 2.14
GTEx Breast Mammary Tissue (Female) 6 0.3650 1.93
GTEx Cells EBV-transformed lymphocytes 6 0.4216 1.88
GTEx Cells Transformed fibroblasts 23 0.5477 2.10
GTEx Colon Sigmoid 5 0.3420 1.95
GTEx Colon Transverse 10 0.4845 2.07
GTEx Esophagus Gastroesophageal Junction 5 0.3460 1.84
GTEx Esophagus Mucosa 15 0.4518 1.95
GTEx Esophagus Muscularis 10 0.3094 1.95
GTEx Heart Atrial Appendage 7 0.4433 2.11
GTEx Heart Left Ventricle 5 0.3268 1.79
GTEx Liver 3 0.4184 1.88
GTEx Lung 9 0.3133 1.94
GTEx Muscle Skeletal 13 0.4498 1.98
GTEx Nerve Tibial 15 0.3471 1.94
GTEx Ovary 5 0.5507 1.91
GTEx Pancreas 8 0.4902 2.09
GTEx Pituitary 6 0.5381 1.97
GTEx Prostate 5 0.5988 1.88
GTEx Skin Not Sun Exposed Suprapubic 17 0.6913 2.03
GTEx Skin Sun Exposed Lower leg 18 0.4945 2.08
GTEx Small Intestine Terminal Ileum 1 0.2169 1.72
GTEx Spleen 10 0.7087 2.22
GTEx Stomach 5 0.3439 1.83
GTEx Testis 15 0.4754 1.95
GTEx Thyroid 19 0.4751 2.08
GTEx Uterus 1 0.1764 1.77
GTEx Vagina 0 0.0000 1.67
GTEx Whole Blood 13 0.6523 2.27
METSIM Adipose 20 0.4338 1.95
NTR Blood 16 0.6661 2.17
ROSMAP Brain Pre-frontal Cortex 20 0.4555 1.94
YFS Blood 24 0.5197 2.03
CommonMind Brain Pre-frontal Cortex 23 0.4279 1.94
TCGA Breast Tumor 5 0.6519 2.08
TCGA Breast Normal 14 0.3328 1.82
TCGA Ovarian Tumor 7 0.2396 1.75
TCGA Prostate Tumor 14 0.4047 1.91