Hub : Traits :

Peak expiratory flow (PEF)

675 significantly associated models · 151 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 2261222 8 1 1.3e-09 1.5e-11 1.6e-03 78 PUSL1
2 1 18940380 20350374 1 1 1.5e-08 7.1e-10 1.7e-03 74 PQLC2
3 1 25695835 27488299 2 2 8.8e-09 1.5e-07 1.7e-01 93 DHDDS TRIM63
4 1 77464831 79041520 2 1 2.5e-07 2.8e-07 1.0e+00 100 FAM73A
5 1 203793652 206329620 7 3 1.1e-16 1.3e-28 4.4e-11 65 MDM4 NUCKS1
6 1 234956342 236357391 1 1 1.6e-07 1.2e-06 4.8e-01 98 B3GALNT2
7 2 42767044 44157441 1 1 1.9e-07 2.5e-12 2.2e-06 54 AC010883.5
8 2 190689771 192091293 1 1 1.7e-07 3.5e-07 1.9e-02 79 TMEM194B
9 2 241805851 243048760 1 1 4.1e-08 2.4e-06 1.3e-01 90 BOK
10 3 24520283 26329265 1 1 4.1e-07 9.6e-07 4.6e-02 83 RARB
11 3 49030828 50448632 1 1 1.2e-08 1.4e-04 2.6e-01 91 RNF123
12 4 17104059 18533844 2 1 9.3e-12 5.0e-11 3.0e-02 89 DCAF16
13 4 144230902 146788825 5 3 9.2e-35 3.0e-63 6.7e-22 67 ANAPC10 HHIP-AS1 RP11-361D14.2
14 5 147063674 148712150 2 1 1.1e-09 3.2e-15 4.8e-07 59 FBXO38
15 5 156009720 157697754 2 1 8.6e-14 8.9e-13 2.4e-01 97 ADAM19
16 6 34399814 36121375 3 1 2.0e-10 7.1e-10 2.9e-02 87 ZNF76
17 6 108994161 110710018 6 1 2.9e-10 3.9e-09 5.9e-01 99 SMPD2
18 6 148844451 150429697 1 1 3.0e-11 6.6e-12 1.0e+00 100 TAB2
19 7 6502367 7988091 1 1 1.7e-08 1.3e-06 6.2e-01 99 C1GALT1
20 8 8092025 12966739 16 1 1.6e-11 7.0e-12 6.9e-03 84 ERI1
21 8 130062993 131498180 1 1 1.4e-08 3.7e-09 9.0e-02 92 GSDMC
22 9 126927285 128824378 6 1 4.9e-08 2.0e-08 1.0e+00 100 RABEPK
23 9 135629944 137034272 1 1 2.3e-08 5.9e-14 4.4e-07 55 CACFD1
24 10 11477584 13569805 4 2 2.4e-14 1.2e-17 3.9e-02 94 CDC123 SEC61A2
25 10 29603847 31102564 1 1 3.7e-13 1.7e-15 3.1e-04 80 KIAA1462
26 10 104308193 105694301 1 1 9.6e-08 1.6e-06 9.7e-02 88 RP11-332O19.5
27 11 65594820 67856510 2 2 4.6e-17 6.5e-16 1.0e+00 100 RAD9A ZDHHC24
28 11 72325482 73717074 1 1 8.9e-08 1.1e-06 1.0e-01 89 RP11-800A3.7
29 12 49780778 51189619 1 1 9.7e-09 4.2e-08 6.1e-01 99 SMARCD1
30 12 84732189 86337816 1 1 8.7e-09 1.9e-10 9.2e-04 73 LRRIQ1
31 12 101713020 103148974 1 1 7.2e-08 9.9e-12 6.5e-06 56 CCDC53
32 13 49905672 51799192 2 2 9.8e-10 2.8e-10 1.0e+00 100 DLEU1 DLEU2
33 15 70697945 72771648 1 1 1.3e-16 1.2e-14 8.8e-01 100 THSD4
34 15 83167559 84434423 1 1 5.6e-08 9.8e-08 3.3e-03 70 BTBD1
35 16 13697975 14759768 1 1 1.4e-14 2.2e-14 1.0e+00 100 RP11-65J21.3
36 16 74578110 76197034 3 1 8.4e-08 1.6e-08 1.0e+00 100 TMEM170A
37 17 27876561 29313078 1 1 3.0e-07 2.8e-06 3.0e-01 95 BLMH
38 17 36211659 37597185 1 1 5.3e-08 6.1e-08 1.0e+00 100 PCGF2
39 17 42774693 45796313 21 1 7.7e-15 2.0e-13 2.3e-01 97 MAPT
40 17 45921906 47318157 1 1 3.2e-08 4.2e-06 2.4e-01 93 HOXB2
41 17 61106371 62710764 6 1 1.2e-10 6.4e-10 6.0e-01 99 CD79B
42 17 63601146 65498820 1 1 3.0e-07 5.2e-07 7.3e-02 87 PRKCA
43 17 79237900 80685655 3 1 1.0e-11 7.9e-11 1.0e+00 100 ASPSCR1
44 19 48464978 49906278 2 1 2.4e-07 2.1e-07 1.8e-01 93 NTN5
45 20 32254831 35298668 22 2 1.8e-16 2.0e-19 1.2e-03 87 TP53INP2 UQCC1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.60 2 2 6.1 0.00 1.0e+00 AC010883.5 NTN5
Irritable Bowel Disease (IBD) 1.66 4 1 3.0 0.58 4.2e-01 AC010883.5 NUCKS1 PUSL1 RNF123
Ulcerative Colitis (UC) 1.58 3 0 0.0 0.00 1.0e+00 NUCKS1 PUSL1 RNF123
Verbal and Numeric Reasoning (VNR) 1.91 4 3 9.1 -1.00 2.8e-03 DCAF16 MAPT RARB RNF123
Breast Cancer 1.12 1 1 3.0 0.00 1.0e+00 MAPT
Ovarian Cancer 1.77 2 1 3.0 0.00 1.0e+00 HOXB2 MAPT
Prostate Cancer 2.77 3 1 3.0 -0.74 2.6e-01 CD79B MDM4 NUCKS1
Crohns Disease (2012) 1.85 1 0 0.0 0.00 1.0e+00 NTN5
LDL Cholesterol 2.00 2 1 3.0 0.00 1.0e+00 CACFD1 NTN5
Lupus 2.14 2 0 0.0 0.00 1.0e+00 TMEM194B ZNF76
Neuroticism 1.81 2 1 3.0 0.00 1.0e+00 ERI1 MAPT
Primary Biliary Cirrhosis 2.09 1 0 0.0 0.00 1.0e+00 TMEM194B
Schizophrenia 1.31 3 0 0.0 0.00 1.0e+00 ERI1 MDM4 RP11-332O19.5
Blood Eosinophil Count 1.25 10 6 18.2 0.11 7.6e-01 AC010883.5 CACFD1 DLEU1 DLEU2 MAPT MDM4 PCGF2 SMPD2 TRIM63 ZNF76
Blood Platelet Count 1.67 17 10 30.3 0.53 2.7e-02 AC010883.5 BLMH CACFD1 DCAF16 HOXB2 KIAA1462 NTN5 PRKCA RARB RP11-332O19.5 RP11-361D14.2 RP11-800A3.7 SMARCD1 SMPD2 TMEM170A TMEM194B TRIM63
Blood Red Count 2.09 9 7 21.2 0.13 7.4e-01 ASPSCR1 BLMH CACFD1 CD79B HOXB2 KIAA1462 MAPT RAD9A SMPD2
Blood White Count 1.24 9 7 21.2 0.16 6.8e-01 BLMH CACFD1 DCAF16 FBXO38 MAPT RP11-332O19.5 SMPD2 TP53INP2 ZNF76
Heel T-Score 2.31 17 12 36.4 0.38 1.4e-01 AC010883.5 ANAPC10 ASPSCR1 B3GALNT2 BLMH CACFD1 DCAF16 DLEU1 DLEU2 GSDMC HHIP-AS1 MAPT PCGF2 PUSL1 RP11-361D14.2 THSD4 ZNF76
BMI 0.86 4 0 0.0 0.59 4.1e-01 BLMH DCAF16 HOXB2 RNF123
Height 10.02 38 33 100.0 -0.84 2.0e-11 AC010883.5 ANAPC10 ASPSCR1 B3GALNT2 BLMH BOK BTBD1 CACFD1 CCDC53 CD79B CDC123 DCAF16 DHDDS DLEU1 DLEU2 GSDMC HHIP-AS1 HOXB2 MAPT MDM4 NTN5 NUCKS1 PRKCA PUSL1 RAD9A RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 SEC61A2 SMARCD1 SMPD2 TAB2 TMEM170A TP53INP2 TRIM63 UQCC1 ZDHHC24 ZNF76
Waist Hip Ratio (WHR) 2.47 12 8 24.2 0.67 1.7e-02 AC010883.5 ANAPC10 ASPSCR1 CD79B DLEU2 HHIP-AS1 MAPT NTN5 RABEPK RAD9A RP11-361D14.2 UQCC1
Systolic Blood Pressure 2.24 10 5 15.2 0.08 8.3e-01 C1GALT1 CDC123 DCAF16 MAPT NTN5 RP11-800A3.7 SMARCD1 TMEM170A TMEM194B UQCC1
Smoking Status 2.28 3 2 6.1 0.00 1.0e+00 RABEPK RARB RP11-332O19.5
Allergy or Eczema 1.32 3 0 0.0 0.00 1.0e+00 AC010883.5 RP11-332O19.5 TMEM170A
Cardiovascular Disease 1.94 6 4 12.1 0.68 1.4e-01 C1GALT1 DCAF16 NTN5 SMARCD1 TMEM170A ZNF76
Hypothyroidism (self reported) 1.55 4 1 3.0 -0.16 8.4e-01 NTN5 PQLC2 PUSL1 TMEM194B
Respiratory disease 2.12 3 2 6.1 0.00 1.0e+00 ADAM19 PCGF2 ZNF76
Type 2 Diabetes (T2D) 2.43 3 2 6.1 0.00 1.0e+00 AC010883.5 C1GALT1 FBXO38
Lung FEV1/FVC ratio 16.20 27 20 60.6 -0.87 1.5e-09 AC010883.5 ADAM19 BLMH BTBD1 C1GALT1 CDC123 DHDDS DLEU1 FBXO38 HHIP-AS1 HOXB2 MAPT NTN5 NUCKS1 PCGF2 PQLC2 RARB RNF123 RP11-332O19.5 RP11-361D14.2 RP11-800A3.7 SEC61A2 SMPD2 THSD4 TMEM170A UQCC1 ZNF76
Lung FVC 5.27 30 19 57.6 -0.55 1.2e-03 ANAPC10 ASPSCR1 BOK BTBD1 C1GALT1 CACFD1 CCDC53 CD79B CDC123 DCAF16 DHDDS FAM73A FBXO38 HOXB2 LRRIQ1 MAPT MDM4 NUCKS1 PQLC2 RAD9A RNF123 RP11-361D14.2 SEC61A2 SMPD2 THSD4 TMEM194B TRIM63 UQCC1 ZDHHC24 ZNF76
Neuroticism 2.26 2 1 3.0 0.00 1.0e+00 MAPT PCGF2
Chronotype (morning person) 1.22 1 0 0.0 0.00 1.0e+00 SMARCD1
Hair Pigment 0.76 7 5 15.2 0.53 1.8e-01 AC010883.5 ASPSCR1 BTBD1 NUCKS1 TP53INP2 UQCC1 ZNF76
Tanning 1.24 3 2 6.1 0.00 1.0e+00 RP11-332O19.5 TP53INP2 UQCC1
Hand grip strength (left) 5.32 11 8 24.2 0.86 3.2e-04 CD79B DCAF16 HOXB2 MAPT NUCKS1 PCGF2 RABEPK RAD9A RP11-332O19.5 UQCC1 ZNF76
Number of treatments/medications taken 2.19 3 0 0.0 0.00 1.0e+00 C1GALT1 DCAF16 NUCKS1
Average weekly spirits intake 1.67 1 0 0.0 0.00 1.0e+00 NTN5
Sensitivity / hurt feelings 2.55 2 1 3.0 0.00 1.0e+00 ERI1 MAPT
Frequency of depressed mood in last 2 weeks 1.25 1 0 0.0 0.00 1.0e+00 MAPT
Hearing difficulty/problems: Yes 1.38 1 0 0.0 0.00 1.0e+00 MAPT
Relative age of first facial hair 2.75 3 2 6.1 0.00 1.0e+00 MAPT MDM4 RP11-65J21.3
Systolic blood pressure, automated reading 2.32 7 4 12.1 -0.31 4.9e-01 DCAF16 ERI1 KIAA1462 MAPT NTN5 SMARCD1 TMEM170A
Medication: Metformin 1.92 1 1 3.0 0.00 1.0e+00 AC010883.5
Diabetes (father) 1.85 1 1 3.0 0.00 1.0e+00 AC010883.5
Diabetes (mother) 2.12 2 0 0.0 0.00 1.0e+00 AC010883.5 SEC61A2
Impedance of leg (right) 2.01 9 7 21.2 -0.06 8.6e-01 AC010883.5 CD79B ERI1 MAPT NUCKS1 RAD9A SMARCD1 SMPD2 UQCC1
Leg fat-free mass (left) 5.62 19 14 42.4 0.88 2.4e-07 ANAPC10 BOK CD79B DCAF16 DHDDS DLEU2 ERI1 GSDMC HHIP-AS1 NTN5 NUCKS1 RAD9A RP11-332O19.5 RP11-361D14.2 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Trunk fat percentage 1.36 5 3 9.1 0.29 6.3e-01 CD79B MAPT RAD9A RARB TP53INP2
Hand grip strength (right) 5.75 13 8 24.2 0.87 4.6e-05 CCDC53 CD79B DCAF16 HOXB2 MAPT NUCKS1 PCGF2 RABEPK RAD9A RP11-332O19.5 TP53INP2 UQCC1 ZNF76
Current tobacco smoking 1.92 2 2 6.1 0.00 1.0e+00 RABEPK RP11-332O19.5
Maternal smoking around birth 1.75 2 0 0.0 0.00 1.0e+00 DCAF16 RP11-332O19.5
Fed-up feelings 1.96 2 1 3.0 0.00 1.0e+00 AC010883.5 MAPT
Relative age voice broke 2.04 3 2 6.1 0.00 1.0e+00 MAPT RP11-65J21.3 UQCC1
Age when periods started (menarche) 2.06 4 1 3.0 0.42 5.8e-01 MAPT NUCKS1 RP11-65J21.3 SMPD2
Heel bone mineral density (BMD) T-score, automated (left) 2.05 4 2 6.1 0.06 9.4e-01 DLEU2 ERI1 HHIP-AS1 MAPT
High blood pressure 1.99 7 4 12.1 -0.42 3.5e-01 C1GALT1 DCAF16 ERI1 MAPT NTN5 SMARCD1 TMEM170A
Hayfever, allergic rhinitis or eczema 1.43 3 0 0.0 0.00 1.0e+00 AC010883.5 RP11-332O19.5 TMEM170A
Medication: Levothyroxine sodium 1.68 2 0 0.0 0.00 1.0e+00 ERI1 PUSL1
Sitting height 10.58 26 22 66.7 0.91 8.8e-11 ANAPC10 ASPSCR1 B3GALNT2 BOK CACFD1 CD79B DCAF16 DHDDS DLEU1 DLEU2 GSDMC HHIP-AS1 HOXB2 MAPT NTN5 NUCKS1 PRKCA RAD9A RP11-361D14.2 RP11-65J21.3 SMARCD1 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Chronic bronchitis/emphysema (father) 1.62 1 0 0.0 0.00 1.0e+00 HHIP-AS1
High blood pressure (mother) 2.30 1 0 0.0 0.00 1.0e+00 TMEM170A
Body mass index (BMI) 1.14 3 1 3.0 0.00 1.0e+00 DCAF16 ERI1 HOXB2
Impedance of leg (left) 2.05 10 5 15.2 0.00 9.9e-01 AC010883.5 CD79B ERI1 HOXB2 MAPT NUCKS1 RAD9A SMARCD1 SMPD2 UQCC1
Leg predicted mass (left) 5.63 19 14 42.4 0.88 2.4e-07 ANAPC10 BOK CD79B DCAF16 DHDDS DLEU2 ERI1 GSDMC HHIP-AS1 NTN5 NUCKS1 RAD9A RP11-332O19.5 RP11-361D14.2 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Trunk fat mass 1.90 10 5 15.2 0.72 1.9e-02 ANAPC10 BOK ERI1 MAPT RAD9A RARB RP11-361D14.2 SMPD2 TP53INP2 UQCC1
Waist circumference 1.24 4 1 3.0 0.52 4.8e-01 FBXO38 HOXB2 RAD9A RP11-332O19.5
Number of incorrect matches in round 1.71 2 0 0.0 0.00 1.0e+00 BLMH NUCKS1
Past tobacco smoking 2.28 2 1 3.0 0.00 1.0e+00 RABEPK RP11-332O19.5
Nervous feelings 2.24 3 2 6.1 0.00 1.0e+00 ERI1 FBXO38 MAPT
Frequency of tenseness / restlessness in last 2 weeks 1.51 1 1 3.0 0.00 1.0e+00 MAPT
Hearing difficulty/problems with background noise 2.10 2 2 6.1 0.00 1.0e+00 MAPT NUCKS1
Hair/balding pattern: Pattern 2 1.60 1 0 0.0 0.00 1.0e+00 MAPT
Forced vital capacity (FVC) 9.56 32 22 66.7 0.91 2.7e-13 ANAPC10 ASPSCR1 BLMH BOK CACFD1 CCDC53 CD79B CDC123 DCAF16 DHDDS DLEU2 FAM73A GSDMC HHIP-AS1 LRRIQ1 MAPT MDM4 PRKCA RABEPK RAD9A RNF123 RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 SEC61A2 SMARCD1 SMPD2 TP53INP2 TRIM63 UQCC1 ZDHHC24 ZNF76
Heel bone mineral density (BMD) T-score, automated (right) 2.11 4 2 6.1 -0.04 9.6e-01 DLEU2 ERI1 HHIP-AS1 MAPT
Ever unenthusiastic/disinterested for a whole week 1.30 1 0 0.0 0.00 1.0e+00 MAPT
Qualifications: None of the above 1.94 1 0 0.0 0.00 1.0e+00 RNF123
Mouth/teeth dental problems 1.93 3 0 0.0 0.00 1.0e+00 ERI1 MAPT NTN5
Diabetes (self-reported) 1.87 3 1 3.0 0.00 1.0e+00 AC010883.5 C1GALT1 FBXO38
Medication: Simvastatin 1.91 1 0 0.0 0.00 1.0e+00 NTN5
Fluid intelligence score 2.06 4 1 3.0 0.99 5.1e-03 DCAF16 MAPT RARB RNF123
Neuroticism score 2.79 5 2 6.1 -0.44 4.5e-01 AC010883.5 ERI1 FBXO38 MAPT NUCKS1
Weight 3.62 17 12 36.4 0.89 6.6e-07 ANAPC10 BOK CD79B DCAF16 DLEU2 ERI1 GSDMC HHIP-AS1 NTN5 NUCKS1 RAD9A RP11-332O19.5 RP11-361D14.2 SMPD2 TP53INP2 TRIM63 UQCC1
Impedance of arm (right) 1.71 6 3 9.1 0.04 9.3e-01 CCDC53 CD79B ERI1 MAPT NUCKS1 SMARCD1
Arm fat percentage (right) 1.39 8 3 9.1 -0.81 1.5e-02 BLMH CD79B DCAF16 ERI1 RARB RNF123 ZDHHC24 ZNF76
Trunk fat-free mass 7.60 22 19 57.6 0.93 1.4e-10 ANAPC10 B3GALNT2 BOK CCDC53 CD79B DCAF16 DHDDS DLEU2 GSDMC HHIP-AS1 NTN5 NUCKS1 PRKCA RAD9A RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Hip circumference 2.84 12 8 24.2 0.87 2.2e-04 ANAPC10 BOK DLEU2 ERI1 HHIP-AS1 NTN5 RAD9A RP11-332O19.5 RP11-361D14.2 SMPD2 TP53INP2 UQCC1
Alcohol intake versus 10 years previously 1.36 1 0 0.0 0.00 1.0e+00 NTN5
Father's age at death 2.02 1 0 0.0 0.00 1.0e+00 ERI1
Worrier / anxious feelings 2.49 4 3 9.1 -0.40 6.0e-01 C1GALT1 ERI1 MAPT RP11-332O19.5
Hair/balding pattern: Pattern 3 1.92 1 1 3.0 0.00 1.0e+00 MAPT
Number of live births 1.58 1 0 0.0 0.00 1.0e+00 MAPT
Forced expiratory volume in 1-second (FEV1) 12.63 40 30 90.9 0.97 6.0e-25 ADAM19 ANAPC10 ASPSCR1 B3GALNT2 BOK BTBD1 C1GALT1 CACFD1 CD79B CDC123 DCAF16 DHDDS DLEU1 DLEU2 ERI1 FAM73A FBXO38 GSDMC HHIP-AS1 LRRIQ1 MAPT MDM4 PCGF2 PQLC2 RABEPK RAD9A RNF123 RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 RP11-800A3.7 SEC61A2 SMARCD1 SMPD2 THSD4 TP53INP2 TRIM63 UQCC1 ZDHHC24 ZNF76
Noisy workplace 1.80 2 0 0.0 0.00 1.0e+00 KIAA1462 MAPT
Qualifications: A levels/AS levels or equivalent 1.75 4 1 3.0 0.98 2.0e-02 DCAF16 MAPT RNF123 UQCC1
Serious illness, injury or assault of a close relative in last 2 years 1.44 1 0 0.0 0.00 1.0e+00 NTN5
Mouth/teeth dental problems: Dentures 1.74 2 0 0.0 0.00 1.0e+00 ERI1 NTN5
Asthma 1.96 2 2 6.1 0.00 1.0e+00 ADAM19 ZNF76
Medication: Ibuprofen (e.g. Nurofen) 1.31 1 0 0.0 0.00 1.0e+00 MAPT
Medication: Cholesterol lowering 1.79 1 0 0.0 0.00 1.0e+00 NTN5
Illnesses of mother 2.22 2 0 0.0 0.00 1.0e+00 DCAF16 PQLC2
Forced expiratory volume in 1-second (FEV1), Best measure 12.42 33 27 81.8 0.97 1.5e-20 ADAM19 ANAPC10 ASPSCR1 BOK BTBD1 C1GALT1 CACFD1 CD79B CDC123 DCAF16 DHDDS DLEU2 ERI1 FBXO38 GSDMC HHIP-AS1 LRRIQ1 MAPT MDM4 PCGF2 RAD9A RNF123 RP11-361D14.2 RP11-65J21.3 RP11-800A3.7 SEC61A2 SMPD2 THSD4 TP53INP2 TRIM63 UQCC1 ZDHHC24 ZNF76
Impedance of arm (left) 1.54 5 3 9.1 0.45 4.4e-01 CD79B ERI1 MAPT NUCKS1 RAD9A
Arm fat mass (right) 1.32 4 1 3.0 0.37 6.3e-01 ERI1 SMPD2 TP53INP2 UQCC1
Trunk predicted mass 7.64 23 19 57.6 0.93 6.9e-11 ANAPC10 B3GALNT2 BOK CCDC53 CD79B DCAF16 DHDDS DLEU2 GSDMC HHIP-AS1 NTN5 NUCKS1 PRKCA RABEPK RAD9A RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Standing height 9.84 31 28 84.8 0.85 6.2e-10 ANAPC10 ASPSCR1 B3GALNT2 BLMH BOK CACFD1 CD79B DCAF16 DHDDS DLEU1 DLEU2 ERI1 GSDMC HHIP-AS1 HOXB2 MAPT NTN5 NUCKS1 PRKCA PUSL1 RAD9A RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 SMARCD1 SMPD2 TMEM170A TP53INP2 TRIM63 UQCC1 ZNF76
Tense / 'highly strung' 1.57 3 0 0.0 0.00 1.0e+00 ERI1 MAPT NUCKS1
Hair/balding pattern: Pattern 4 2.67 2 1 3.0 0.00 1.0e+00 AC010883.5 MAPT
Birth weight of first child 3.26 6 4 12.1 0.93 6.5e-03 ANAPC10 ASPSCR1 DCAF16 RP11-361D14.2 TMEM170A ZNF76
Blood clot in the leg (DVT) 1.73 1 1 3.0 0.00 1.0e+00 CACFD1
Medication: Paracetamol 2.04 1 1 3.0 0.00 1.0e+00 MAPT
Headache pain in last month 2.10 2 2 6.1 0.00 1.0e+00 MAPT TMEM170A
Hypothyroidism/myxoedema (self-reported) 1.77 3 1 3.0 0.00 1.0e+00 ERI1 PUSL1 TMEM194B
Birth weight 3.68 5 4 12.1 0.07 8.9e-01 ANAPC10 DCAF16 NUCKS1 RP11-361D14.2 ZNF76
Chronic bronchitis/emphysema (mother) 2.39 2 0 0.0 0.00 1.0e+00 HHIP-AS1 RARB
Forced vital capacity (FVC), Best measure 9.60 28 23 69.7 0.91 9.8e-12 ANAPC10 ASPSCR1 BLMH BOK CACFD1 CCDC53 CD79B CDC123 DCAF16 DHDDS DLEU2 FBXO38 GSDMC HHIP-AS1 LRRIQ1 MAPT MDM4 PRKCA RAD9A RNF123 RP11-361D14.2 RP11-65J21.3 SMPD2 TP53INP2 TRIM63 UQCC1 ZDHHC24 ZNF76
Body fat percentage 1.33 6 1 3.0 -0.65 1.6e-01 BLMH CD79B DCAF16 ERI1 RARB ZNF76
Leg fat percentage (right) 1.72 6 4 12.1 -0.79 6.3e-02 BLMH CD79B DCAF16 DLEU1 ERI1 UQCC1
Arm fat-free mass (right) 6.49 20 19 57.6 0.94 2.6e-10 ANAPC10 BOK CCDC53 CD79B DCAF16 DHDDS DLEU2 GSDMC HHIP-AS1 NTN5 NUCKS1 RAD9A RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Exposure to tobacco smoke outside home 2.03 1 0 0.0 0.00 1.0e+00 RP11-332O19.5
Comparative body size at age 10 1.82 4 3 9.1 0.13 8.4e-01 ERI1 NTN5 NUCKS1 SMARCD1
Worry too long after embarrassment 1.68 2 0 0.0 0.00 1.0e+00 ERI1 MAPT
Wheeze or whistling in the chest in last year 2.47 2 0 0.0 0.00 1.0e+00 ADAM19 TAB2
Age at first live birth 1.80 1 0 0.0 0.00 1.0e+00 DCAF16
Health satisfaction 1.78 2 0 0.0 0.00 1.0e+00 HOXB2 ZDHHC24
Qualifications: College or University degree 1.90 5 2 6.1 0.96 1.0e-02 B3GALNT2 CACFD1 MAPT RNF123 UQCC1
Medication for pain relief, constipation, heartburn 1.90 2 1 3.0 0.00 1.0e+00 MAPT NUCKS1
Medication: Blood pressure 1.69 1 0 0.0 0.00 1.0e+00 ERI1
Mean time to correctly identify matches 1.12 1 0 0.0 0.00 1.0e+00 NUCKS1
Heart disease (mother) 1.73 1 0 0.0 0.00 1.0e+00 PCGF2
Whole body fat mass 1.58 6 3 9.1 0.76 7.9e-02 ANAPC10 ERI1 RAD9A RP11-361D14.2 TP53INP2 UQCC1
Leg fat mass (right) 1.27 3 1 3.0 0.00 1.0e+00 BLMH ERI1 RAD9A
Arm predicted mass (right) 6.49 20 19 57.6 0.94 2.0e-10 ANAPC10 BOK CCDC53 CD79B DCAF16 DHDDS DLEU2 GSDMC HHIP-AS1 NTN5 NUCKS1 RAD9A RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Pulse rate, automated reading 1.45 3 2 6.1 0.00 1.0e+00 PCGF2 TMEM194B TRIM63
Alcohol intake frequency. 1.41 2 2 6.1 0.00 1.0e+00 MAPT NTN5
Comparative height size at age 10 8.43 24 20 60.6 0.88 8.8e-09 AC010883.5 ANAPC10 ASPSCR1 BOK CCDC53 CD79B DCAF16 DHDDS DLEU1 DLEU2 GSDMC HHIP-AS1 MAPT NTN5 NUCKS1 PRKCA RAD9A RP11-361D14.2 SMPD2 TMEM170A TP53INP2 TRIM63 UQCC1 ZNF76
Suffer from 'nerves' 1.39 1 0 0.0 0.00 1.0e+00 MAPT
Overall health rating 2.31 6 1 3.0 -1.00 6.6e-06 DCAF16 ERI1 HOXB2 RABEPK RARB ZDHHC24
Chest pain or discomfort 1.60 1 0 0.0 0.00 1.0e+00 C1GALT1
Knee pain experienced in last month 1.52 1 1 3.0 0.00 1.0e+00 UQCC1
Hypertension (Self-reported) 2.04 7 4 12.1 -0.45 3.2e-01 C1GALT1 DCAF16 ERI1 MAPT NTN5 SMARCD1 TMEM170A
Smoking status: Previous 1.94 1 0 0.0 0.00 1.0e+00 RP11-332O19.5
Forced expiratory volume in 1-second (FEV1), predicted 6.59 13 9 27.3 0.93 2.8e-06 ANAPC10 BOK CD79B DCAF16 DLEU2 GSDMC HHIP-AS1 RAD9A RP11-361D14.2 TP53INP2 TRIM63 UQCC1 ZNF76
Whole body fat-free mass 6.90 21 19 57.6 0.93 3.0e-10 ANAPC10 B3GALNT2 BOK CCDC53 CD79B DCAF16 DHDDS DLEU2 GSDMC HHIP-AS1 NTN5 NUCKS1 RAD9A RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Leg fat-free mass (right) 5.73 20 14 42.4 0.88 1.2e-07 ANAPC10 BOK CCDC53 CD79B DCAF16 DLEU1 DLEU2 ERI1 GSDMC HHIP-AS1 NTN5 NUCKS1 RAD9A RP11-332O19.5 RP11-361D14.2 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Arm fat percentage (left) 1.36 8 2 6.1 -0.80 1.6e-02 BLMH CD79B DCAF16 ERI1 RARB RNF123 ZDHHC24 ZNF76
Handedness (chirality/laterality): Left-handed 1.60 1 1 3.0 0.00 1.0e+00 MAPT
Mood swings 2.48 2 1 3.0 0.00 1.0e+00 MAPT NUCKS1
Loneliness, isolation 1.18 1 0 0.0 0.00 1.0e+00 MAPT
Long-standing illness, disability or infirmity 1.74 1 0 0.0 0.00 1.0e+00 RARB
Diabetes diagnosed by doctor 2.13 1 1 3.0 0.00 1.0e+00 AC010883.5
Friendships satisfaction 1.32 1 0 0.0 0.00 1.0e+00 RP11-65J21.3
Mouth/teeth dental problems: Mouth ulcers 1.44 1 1 3.0 0.00 1.0e+00 MAPT
Medication for cholesterol 1.83 2 0 0.0 0.00 1.0e+00 MAPT NTN5
Asthma (self-reported) 1.86 2 2 6.1 0.00 1.0e+00 ADAM19 ZNF76
Smoking status: Current 1.96 2 2 6.1 0.00 1.0e+00 RABEPK RP11-332O19.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.87 20 10 30.3 0.97 1.3e-12 ADAM19 ASPSCR1 BOK C1GALT1 CD79B CDC123 DHDDS ERI1 FBXO38 HHIP-AS1 MAPT PCGF2 RARB RNF123 RP11-361D14.2 SMPD2 THSD4 TMEM170A TRIM63 ZNF76
Whole body water mass 6.82 21 18 54.5 0.93 2.8e-10 ANAPC10 B3GALNT2 BOK CCDC53 CD79B DCAF16 DHDDS DLEU2 GSDMC HHIP-AS1 NTN5 NUCKS1 RAD9A RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Leg predicted mass (right) 5.72 21 14 42.4 0.88 5.8e-08 ANAPC10 BOK CCDC53 CD79B DCAF16 DHDDS DLEU1 DLEU2 ERI1 GSDMC HHIP-AS1 NTN5 NUCKS1 RAD9A RP11-332O19.5 RP11-361D14.2 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Arm fat mass (left) 1.31 4 1 3.0 0.40 6.0e-01 ERI1 RAD9A TP53INP2 UQCC1
Number of self-reported non-cancer illnesses 2.04 2 0 0.0 0.00 1.0e+00 NTN5 ZDHHC24
Average weekly champagne plus white wine intake 1.29 1 0 0.0 0.00 1.0e+00 MAPT
Miserableness 1.60 2 1 3.0 0.00 1.0e+00 ERI1 MAPT
Guilty feelings 1.54 2 0 0.0 0.00 1.0e+00 MAPT RNF123
Medication: Blood pressure 1.93 3 2 6.1 0.00 1.0e+00 C1GALT1 ERI1 MAPT
High cholesterol (Self-reported) 2.45 2 1 3.0 0.00 1.0e+00 DCAF16 NTN5
Medication: Bendroflumethiazide 1.80 2 0 0.0 0.00 1.0e+00 C1GALT1 ERI1
Medication: Paracetamol 2.13 1 1 3.0 0.00 1.0e+00 MAPT
Ever smoked 1.89 2 1 3.0 0.00 1.0e+00 RABEPK RP11-332O19.5
Basal metabolic rate 6.15 21 16 48.5 0.89 3.1e-08 ANAPC10 BOK CCDC53 CD79B DCAF16 DHDDS DLEU2 ERI1 GSDMC HHIP-AS1 NTN5 NUCKS1 RAD9A RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Leg fat percentage (left) 1.71 7 3 9.1 -0.80 2.9e-02 BLMH CD79B DCAF16 DLEU1 ERI1 UQCC1 ZNF76
Arm fat-free mass (left) 6.10 20 18 54.5 0.94 3.0e-10 ANAPC10 BOK CCDC53 CD79B DCAF16 DHDDS DLEU2 GSDMC HHIP-AS1 NTN5 NUCKS1 RAD9A RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76
Average weekly beer plus cider intake 1.98 2 0 0.0 0.00 1.0e+00 ERI1 RNF123
Irritability 2.12 3 2 6.1 0.00 1.0e+00 AC010883.5 ERI1 MAPT
Diastolic blood pressure, automated reading 2.22 8 5 15.2 -0.48 2.3e-01 C1GALT1 DCAF16 ERI1 HOXB2 RP11-800A3.7 SMARCD1 THSD4 ZNF76
Ever depressed for a whole week 1.29 1 0 0.0 0.00 1.0e+00 MAPT
Vascular/heart problems diagnosed by doctor 1.96 6 3 9.1 0.76 8.2e-02 C1GALT1 DCAF16 ERI1 NTN5 SMARCD1 TMEM170A
Cholesterol lowering medication 1.84 2 0 0.0 0.00 1.0e+00 BLMH NTN5
Pain experienced in last month 1.78 2 1 3.0 0.00 1.0e+00 MAPT RABEPK
Deep venous thrombosis (DVT) (self-reported) 1.69 1 1 3.0 0.00 1.0e+00 CACFD1
Heart disease (siblings) 1.48 1 0 0.0 0.00 1.0e+00 TP53INP2
Impedance of whole body 1.75 9 5 15.2 0.02 9.6e-01 AC010883.5 CD79B ERI1 MAPT NUCKS1 RAD9A SMARCD1 SMPD2 UQCC1
Leg fat mass (left) 1.25 2 1 3.0 0.00 1.0e+00 ERI1 RAD9A
Arm predicted mass (left) 6.06 19 19 57.6 0.94 9.4e-10 ANAPC10 BOK CD79B DCAF16 DHDDS DLEU2 GSDMC HHIP-AS1 NTN5 NUCKS1 RAD9A RP11-332O19.5 RP11-361D14.2 RP11-65J21.3 SMPD2 TP53INP2 TRIM63 UQCC1 ZNF76

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 17 0.487 2.35
GTEx Adipose Visceral Omentum 13 0.639 2.46
GTEx Adrenal Gland 10 0.686 2.42
GTEx Artery Aorta 16 0.537 2.44
GTEx Artery Coronary 12 1.014 2.58
GTEx Artery Tibial 20 0.532 2.39
GTEx Brain Caudate basal ganglia 6 0.652 2.38
GTEx Brain Cerebellar Hemisphere 11 0.739 2.36
GTEx Brain Cerebellum 14 0.706 2.44
GTEx Brain Cortex 8 0.773 2.54
GTEx Brain Frontal Cortex BA9 6 0.649 2.64
GTEx Brain Hippocampus 5 0.954 2.36
GTEx Brain Hypothalamus 5 0.847 2.69
GTEx Brain Nucleus accumbens basal ganglia 8 0.925 2.53
GTEx Brain Putamen basal ganglia 5 0.801 2.31
GTEx Breast Mammary Tissue 14 0.709 2.52
GTEx Breast Mammary Tissue (Male) 11 0.922 2.57
GTEx Breast Mammary Tissue (Female) 13 0.791 2.44
GTEx Cells EBV-transformed lymphocytes 10 0.703 2.63
GTEx Cells Transformed fibroblasts 19 0.452 2.33
GTEx Colon Sigmoid 9 0.616 2.63
GTEx Colon Transverse 16 0.775 2.44
GTEx Esophagus Gastroesophageal Junction 11 0.761 2.56
GTEx Esophagus Mucosa 24 0.723 2.47
GTEx Esophagus Muscularis 19 0.588 2.45
GTEx Heart Atrial Appendage 13 0.823 2.62
GTEx Heart Left Ventricle 10 0.654 2.55
GTEx Liver 3 0.418 2.36
GTEx Lung 18 0.627 2.47
GTEx Muscle Skeletal 17 0.588 2.45
GTEx Nerve Tibial 18 0.417 2.35
GTEx Ovary 11 1.211 2.75
GTEx Pancreas 13 0.797 2.51
GTEx Pituitary 8 0.717 2.31
GTEx Prostate 7 0.838 2.42
GTEx Skin Not Sun Exposed Suprapubic 16 0.651 2.51
GTEx Skin Sun Exposed Lower leg 26 0.714 2.52
GTEx Small Intestine Terminal Ileum 5 1.085 2.72
GTEx Spleen 9 0.638 2.46
GTEx Stomach 11 0.757 2.50
GTEx Testis 24 0.761 2.58
GTEx Thyroid 22 0.550 2.41
GTEx Uterus 6 1.058 2.87
GTEx Vagina 6 0.945 2.72
GTEx Whole Blood 11 0.552 2.38
METSIM Adipose 13 0.282 2.20
NTR Blood 9 0.375 2.20
ROSMAP Brain Pre-frontal Cortex 17 0.387 2.20
YFS Blood 12 0.260 2.10
CommonMind Brain Pre-frontal Cortex 20 0.372 2.09
TCGA Breast Tumor 6 0.782 2.44
TCGA Breast Normal 12 0.285 2.01
TCGA Ovarian Tumor 16 0.548 2.19
TCGA Prostate Tumor 14 0.405 2.21