Hub : Genes

TAB2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0740 0.0300 1.1e-03 0.045 0.025 0.013 0.026 0.034 3.1e-06 0.00044 0.00950 0.00037 4.5e-05
2 GTEx Cells Transformed fibroblasts 0.2040 0.0540 1.1e-06 0.055 NA 0.048 NA 0.051 6.0e-05 NA 0.00018 NA 1.1e-04
3 GTEx Skin Not Sun Exposed Suprapubic 0.1470 0.0550 1.4e-03 0.058 NA 0.045 NA 0.049 4.2e-04 NA 0.00160 NA 1.1e-03
4 GTEx Skin Sun Exposed Lower leg 0.0970 0.0410 6.3e-03 0.001 NA 0.014 NA 0.005 2.8e-01 NA 0.02200 NA 1.1e-01
5 ROSMAP Brain Pre-frontal Cortex 0.0511 0.0220 3.9e-03 0.001 0.015 0.007 0.014 0.003 2.5e-01 0.00450 0.03400 0.00620 1.3e-01
6 TCGA Lung Adenocarcinoma 0.0458 0.0238 5.3e-03 0.001 0.013 0.005 NA 0.001 2.2e-01 0.00970 0.08300 NA 2.1e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.5 0.8 2.4 1.5 -0.1 -0.4 1.0 0.4 -1.2
Bipolar Disorder or Schizophrenia 0.1 0.2 0.8 0.9 0.3 -0.1 0.2 0.3 -0.1
Depressed Affect (Nagel 2018) 0.6 1.2 3.4 1.8 0.4 1.4 1.0 1.1 0.1
Depression (Nagel 2018) 1.2 1.7 5.1 2.3 -0.2 1.3 -0.4 1.5 -1.1
Intelligence (Savage-Jansen 2018) 0.3 1.0 2.4 1.6 -0.8 0.2 -0.5 0.6 -1.5
Neuroticism (Nagel 2018) 1.1 2.7 7.2 2.7 -1.0 1.7 1.6 1.5 -0.4
Schizophrenia (2018) 0.1 0.2 0.7 -0.1 0.4 0.2 -0.6 -0.0 0.9
Schizophrenia vs Biploar Disorder 1.1 1.5 4.4 -1.3 -0.2 1.3 0.7 -2.1 0.6
Worry (Nagel 2018) 0.6 1.2 4.7 2.2 -0.8 1.0 -0.2 0.9 0.5
Alzheimer’s Disease (in mother) 0.3 0.3 0.5 -0.5 0.5 0.0 0.7 -0.7 -0.7
Alzheimer’s Disease (in father) 0.5 0.6 1.2 -0.4 -0.8 -1.1 1.1 0.1 0.5
Alzheimer’s Disease (including proxy) 0.6 0.9 3.0 -1.7 0.4 -1.0 0.6 -1.1 -0.2
Crohns Disease (2017) 0.5 1.0 2.1 -0.5 -1.1 -1.0 0.4 -1.1 -1.4
Irritable Bowel Disease (IBD) 1.3 3.0 9.1 -0.6 0.0 -3.0 -1.2 -1.1 -2.4
Ulcerative Colitis (UC) 1.6 3.0 6.3 -0.6 1.5 -2.5 -1.9 -0.5 -2.3
Major Depression (MDD) 0.8 1.0 5.0 -0.5 0.7 2.2 0.3 -0.4 0.3
Reaction Time 0.4 0.8 1.8 0.4 1.3 1.2 1.0 0.0 -0.1
Verbal and Numeric Reasoning (VNR) 0.6 1.4 2.9 1.0 -0.9 1.7 1.2 -0.7 -1.4
Breast Cancer 0.2 0.4 1.1 -0.2 0.5 -0.9 1.0 -0.5 -0.3
Ovarian Cancer 0.7 0.9 4.2 0.0 -0.4 2.1 -0.7 -0.1 -0.8
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.2 1.8 3.1 -1.4 1.8 0.9 0.6 -1.8 1.2
Bipolar Disorder (2011) 0.4 0.4 0.8 0.3 -0.2 -0.9 0.8 0.9 0.4
Body Mass Index (BMI) (2010) 0.8 1.1 3.4 -1.2 -1.0 -0.5 0.3 0.7 -1.8
Coronary Artery Disease (CAD) 2.4 2.8 11.5 1.2 -0.5 -1.4 0.1 1.3 3.4
Crohns Disease (2012) 0.8 1.3 4.7 0.4 -1.1 0.3 0.7 -1.0 -2.2
Mean Putamen Volume 3.1 3.5 6.0 2.0 -1.3 1.2 2.3 2.4 1.6
Fasting Glucose 0.7 0.8 2.5 0.0 -0.3 -1.6 -1.3 0.7 -0.1
HbA1C 1.3 1.4 5.8 0.2 1.3 0.1 -0.4 -1.0 -2.4
HDL Cholesterol 0.5 0.8 2.2 -0.4 -1.5 0.7 1.2 0.2 -0.8
LDL Cholesterol 0.3 0.5 1.7 0.5 1.1 0.3 -1.3 0.1 -0.0
Lupus 0.3 0.5 1.3 -1.0 0.8 0.3 0.1 -1.1 0.3
Neuroticism (2016) 0.6 0.9 3.0 1.0 0.5 1.7 0.2 0.9 0.3
Primary Biliary Cirrhosis 1.1 1.6 4.8 -2.2 0.9 -0.7 -0.5 -1.7 -0.9
Rheumatoid Arthritis 0.6 0.8 3.3 0.6 1.8 0.6 -0.3 -0.2 -0.8
Schizophrenia (2014) 0.3 0.6 1.8 -0.1 1.0 0.8 -0.3 -1.3 0.3
Triglycerides 1.2 2.0 3.8 -2.0 1.2 -1.5 -1.4 -1.6 0.0
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.5 -1.1 -1.0 -1.6 -1.0 -0.2 0.7
Ulcerative Colitis 1.2 1.8 5.1 -0.5 -0.2 -2.1 -0.6 -0.6 -2.3
Blood Eosinophil Count 1.3 9.8 17.1 -3.6 -1.3 3.7 3.6 -4.1 0.3
Blood Platelet Count 0.2 1.9 4.5 0.1 -2.1 1.8 1.4 -0.2 -1.3
Blood Red Count 0.2 1.8 6.8 -0.2 0.3 -2.6 -0.9 -0.0 1.8
Blood White Count 0.5 4.0 10.3 -2.4 -0.3 0.5 1.7 -2.2 -3.2
Heel T-Score 0.2 1.5 6.5 0.5 -1.0 0.5 0.5 1.0 2.5
BMI 0.1 0.9 3.6 -1.0 0.3 -1.9 0.0 0.4 0.5
Height 0.7 13.7 42.8 6.5 0.2 2.0 -3.5 3.1 -3.6
Waist Hip Ratio (WHR) 0.3 1.2 5.0 2.2 0.6 -0.0 -0.6 0.9 0.9
Systolic Blood Pressure 0.3 1.6 5.0 -1.1 -0.7 0.5 0.3 -1.5 2.2
Smoking Status 0.3 0.6 1.9 1.4 0.0 -0.6 -0.8 0.6 -0.6
Allergy or Eczema 0.4 1.1 2.6 0.0 -1.6 1.2 1.3 0.5 0.9
Cardiovascular Disease 0.8 2.5 6.3 -1.0 -2.5 0.6 1.7 -0.5 2.0
Hypothyroidism (self reported) 0.3 0.6 2.5 0.6 1.6 0.5 -0.6 0.3 0.2
Respiratory disease 3.7 8.3 17.2 -3.5 0.5 4.1 2.5 -3.7 -0.6
Type 2 Diabetes (T2D) (2018) 1.1 2.1 5.9 2.4 -1.0 -0.2 1.0 2.0 -0.8
Lung FEV1/FVC ratio 1.2 5.9 15.7 3.2 1.4 -1.5 -4.0 1.9 -1.3
Lung FVC 0.9 4.3 9.4 1.4 -2.3 -3.1 -0.1 3.0 0.2
Neuroticism 1.0 2.4 6.7 2.6 0.0 2.1 -0.9 1.4 -0.7
Chronotype (morning person) 1.0 2.2 5.4 -1.9 -0.4 1.0 0.9 -1.5 -2.3
Hair Pigment 0.0 0.5 1.6 0.4 -0.2 -0.4 1.3 -0.9 -0.5
Tanning 0.1 1.6 3.2 0.0 0.6 1.7 1.6 -0.7 -1.8
Hand grip strength (left) 0.8 2.1 5.9 -0.0 1.9 -2.4 -1.5 0.6 -0.7
Number of treatments/medications taken 0.8 1.4 6.4 0.1 -2.5 -0.5 0.4 1.1 0.6
Average weekly spirits intake 0.5 0.7 2.8 0.1 1.7 0.2 -0.5 -0.8 -0.6
Sensitivity / hurt feelings 0.9 1.5 2.6 1.6 -0.8 1.2 1.6 1.4 0.0
Frequency of depressed mood in last 2 weeks 2.2 3.0 8.1 2.8 0.7 2.1 0.2 1.7 -1.5
Hearing difficulty/problems: Yes 0.4 0.5 1.4 -0.3 0.1 -1.0 1.2 -0.2 0.8
Relative age of first facial hair 0.7 1.5 5.4 -0.6 -1.1 -1.4 2.3 0.3 -0.2
Other serious medical condition/disability diagnosed by doctor 1.5 1.9 3.5 1.6 1.0 -1.6 0.6 1.2 -1.9
Ever used hormone-replacement therapy (HRT) 0.5 0.7 2.1 -0.8 0.1 -1.1 -1.4 -0.3 -0.2
Ever had hysterectomy (womb removed) 0.3 0.3 0.6 0.6 -0.5 0.3 0.1 0.8 0.7
Systolic blood pressure, automated reading 0.6 1.7 3.8 -1.5 -0.4 -0.9 -1.4 -1.0 1.9
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 3.3 -0.3 -0.8 -1.8 -0.4 0.1 -0.0
Angina 2.1 2.7 5.4 1.6 1.1 -1.3 -0.7 2.3 2.3
Medication for hormone replacement therapy 1.2 1.3 3.8 -0.1 1.0 -0.9 -1.9 -0.3 1.4
Vitamin and mineral supplements 0.7 0.9 3.6 -0.4 1.1 0.5 0.0 0.3 1.9
Supplements: Zinc 1.4 1.5 3.0 0.6 -1.5 1.7 1.4 1.0 -0.8
Medication: Co-codamol 2.3 2.7 8.7 3.0 -0.7 -0.6 0.0 2.5 -0.4
Medication: Metformin 1.0 1.5 4.9 2.2 -0.6 0.9 0.7 1.0 -1.0
Diabetes (father) 0.2 0.2 0.5 0.0 0.6 -0.7 -0.2 0.1 -0.6
Diabetes (mother) 1.1 1.4 4.0 -0.4 -2.0 -1.2 -1.4 0.7 0.5
Severe depression (siblings) 2.5 2.8 10.5 0.2 0.4 3.2 1.7 -0.9 -1.6
Pack years adult smoking proportion 0.8 1.2 2.5 -1.5 -0.6 -1.6 -1.4 0.3 -0.3
Impedance of leg (right) 0.8 3.9 16.3 0.0 2.0 4.0 0.0 -1.3 1.1
Leg fat-free mass (left) 0.3 1.4 3.3 1.6 -0.0 -0.9 -0.6 1.2 -1.8
Trunk fat percentage 0.3 1.1 2.6 -1.6 1.0 0.7 -0.1 -1.2 1.1
Hand grip strength (right) 0.9 2.4 4.6 1.3 2.1 -1.7 -1.5 1.4 -1.1
Townsend deprivation index at recruitment 0.8 1.1 3.5 -0.6 0.1 -1.4 -1.9 0.4 0.8
Current tobacco smoking 0.3 0.5 1.7 -0.1 -0.7 -0.7 0.7 0.0 -1.3
Average weekly fortified wine intake 0.9 1.0 2.2 1.3 -0.7 -1.1 0.7 1.5 -0.2
Maternal smoking around birth 0.5 0.8 2.3 0.7 1.2 -0.8 -1.5 0.2 -0.2
Fed-up feelings 0.6 1.0 2.3 1.5 1.3 1.1 -0.2 0.5 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.6 1.2 0.3 0.9 -0.3 1.3 -0.9
Relative age voice broke 0.7 1.0 4.7 -0.8 -0.7 -0.6 2.2 -0.4 0.1
Taking other prescription medications 0.8 1.2 2.2 0.7 -0.5 1.5 1.3 0.7 1.4
Age when periods started (menarche) 0.1 0.3 1.2 0.4 -1.1 0.7 -0.1 0.2 -0.1
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.1 -1.5 0.5 -1.1 -0.2 -0.4 1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.5 -0.4 -0.7 0.1 0.4 0.1 0.2
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.6 -1.2 0.1 0.3 -0.9 -1.1 0.7
Qualifications: CSEs or equivalent 0.7 0.9 3.0 0.3 0.4 1.7 1.2 -0.6 0.6
Serious illness, injury or assault to yourself 0.6 0.7 2.0 0.8 -0.2 -1.4 -0.8 1.0 0.2
High blood pressure 0.6 1.8 7.8 -0.5 -2.8 0.5 1.2 0.3 0.9
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.6 0.2 -1.5 0.1 0.9 0.2 1.6
Multivitamins +/- minerals 0.8 1.0 3.3 -0.6 -0.2 0.4 0.9 -1.3 -1.8
Stomach or abdominal pain in last month 0.5 0.6 1.4 0.7 0.3 1.2 1.1 0.8 -0.2
Supplements: Glucosamine 0.7 0.9 1.7 -0.9 -1.3 -0.6 1.0 -0.7 -1.0
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.5 0.3 0.9 -1.6 -0.3 0.8 -0.2
Medication: Atenolol 1.0 1.3 2.6 1.2 0.2 -1.4 -1.6 0.8 0.9
Medication: Levothyroxine sodium 0.4 0.7 2.3 0.1 1.1 1.5 -0.2 -0.2 -0.6
Sitting height 0.2 1.2 3.4 0.0 0.5 -0.3 -1.5 -1.0 -1.8
Chronic bronchitis/emphysema (father) 1.7 2.0 5.7 0.6 -2.4 1.6 1.3 0.3 1.2
High blood pressure (mother) 0.8 1.1 4.7 2.2 -0.5 -0.8 0.2 1.1 -0.0
Body mass index (BMI) 0.1 0.6 1.7 -0.1 0.8 -1.3 -0.7 0.6 -0.0
Impedance of leg (left) 0.7 3.5 15.9 0.5 1.7 4.0 0.0 -0.9 1.1
Leg predicted mass (left) 0.2 1.3 2.8 1.5 -0.0 -0.9 -0.6 1.2 -1.7
Trunk fat mass 0.1 0.4 1.0 -0.6 1.0 0.5 -0.7 -0.6 0.1
Waist circumference 0.1 0.5 1.6 0.8 0.4 0.4 -0.5 0.5 -1.3
Number of incorrect matches in round 1.5 2.5 6.3 -1.5 1.2 1.2 -1.1 -1.4 -2.5
Past tobacco smoking 0.4 0.8 1.8 -0.5 -1.3 0.9 1.1 -0.5 -0.7
Alcohol usually taken with meals 0.3 0.4 1.3 0.4 -0.4 -0.5 -0.6 0.7 -1.1
Nervous feelings 0.3 0.5 2.0 0.9 0.2 0.6 0.1 0.1 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 2.5 1.2 0.6 1.1 -0.6 1.6 0.4
Hearing difficulty/problems with background noise 0.7 1.1 2.8 1.2 -1.7 0.3 1.2 0.8 0.0
Hair/balding pattern: Pattern 2 2.0 2.6 8.2 1.2 -2.9 -0.3 1.6 1.2 1.2
Had menopause 1.8 2.2 4.3 -2.1 -1.3 1.1 -0.0 -1.5 -1.9
Had other major operations 0.4 0.5 1.3 -0.1 0.1 -0.7 0.6 0.8 1.2
Forced vital capacity (FVC) 0.4 1.5 6.0 2.5 -0.3 -0.5 -0.0 1.7 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.2 -0.3 -0.3 -0.2 -0.2 0.4 0.5
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.0 1.4 1.3 1.4 -0.5 0.7 -0.0
Qualifications: None of the above 0.8 1.6 4.6 -1.1 -0.4 -1.5 -2.1 1.0 0.8
Financial difficulties in last 2 years 0.9 1.2 3.3 1.5 0.7 1.8 0.6 0.9 -0.1
Mouth/teeth dental problems 0.3 0.4 0.9 1.0 0.3 0.7 0.7 -0.3 -0.6
Heart attack 0.2 0.3 1.0 0.2 0.2 -0.7 -0.1 1.0 0.2
Allergy 1.7 3.8 6.4 2.0 2.1 -1.6 -2.5 2.0 -1.3
Pain all over the body in last month 0.6 0.6 3.0 -0.4 0.7 0.4 0.0 0.4 -1.7
Diabetes (self-reported) 0.9 1.3 3.1 1.8 -1.1 -0.6 0.8 1.7 0.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.5 0.5 -0.3 0.7 0.6 -0.1 0.7
Medication: Ramipril 1.2 1.5 5.8 -0.4 -2.4 0.4 0.6 0.7 1.5
Medication: Simvastatin 0.6 0.9 3.1 0.3 -1.8 1.0 0.0 0.2 -1.0
Fluid intelligence score 0.4 0.9 3.8 1.9 -0.5 0.3 0.6 0.3 -1.0
Illnesses of siblings 0.4 0.6 1.5 1.2 -0.1 -1.2 -0.0 0.5 0.6
Neuroticism score 1.0 2.2 7.9 2.8 -0.5 1.0 -0.1 2.0 -0.0
Weight 0.2 0.9 1.3 1.1 1.1 0.0 -1.1 0.7 -1.2
Impedance of arm (right) 1.4 6.7 11.2 -3.3 -0.3 3.0 2.7 -2.8 2.3
Arm fat percentage (right) 0.2 0.7 2.5 -1.6 0.6 -0.1 -0.1 -0.6 0.9
Trunk fat-free mass 1.1 6.2 15.2 3.9 0.9 -0.1 -2.2 2.4 -3.3
Hip circumference 0.4 1.6 5.6 1.1 0.2 1.5 0.1 0.6 -2.4
Time employed in main current job 1.0 1.1 3.2 -1.3 1.8 -0.0 -0.7 -0.9 0.7
Alcohol intake versus 10 years previously 0.4 0.5 1.7 0.8 1.3 -0.7 -0.1 0.6 0.2
Father’s age at death 0.5 0.7 2.4 -0.3 -0.5 0.8 1.6 -0.0 0.8
Worrier / anxious feelings 1.2 2.3 6.9 1.9 -0.9 0.3 -0.2 1.5 2.6
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 2.5 1.6 1.3 0.8 -0.6 1.3 0.4
Falls in the last year 0.2 0.3 0.6 -0.8 -0.6 0.7 0.6 -0.1 0.4
Hair/balding pattern: Pattern 3 0.6 0.9 1.7 -0.6 0.6 1.3 0.7 -1.3 -0.9
Number of live births 1.6 2.3 8.4 -2.9 0.8 -0.7 -0.6 -1.9 0.4
Forced expiratory volume in 1-second (FEV1) 0.9 3.2 10.5 3.2 0.2 -1.0 -1.2 2.4 0.6
Pulse rate 1.1 1.9 3.7 1.6 -1.9 -0.7 -1.7 1.1 0.5
Happiness 2.7 3.3 10.3 3.2 -1.5 0.8 0.3 2.4 -0.7
Noisy workplace 0.7 0.8 1.7 0.4 -1.2 0.9 -1.3 1.0 0.1
Qualifications: A levels/AS levels or equivalent 0.1 0.3 1.2 1.1 -0.4 0.6 -0.2 -0.0 -0.5
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 2.9 1.7 0.6 -0.9 1.5 1.0 -1.0
Mouth/teeth dental problems: Dentures 1.3 2.2 5.8 -2.4 0.2 -1.5 -1.7 -1.4 0.1
Asthma 3.7 7.4 12.9 -2.9 -0.6 3.4 3.3 -3.6 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.3 2.7 0.9 -1.6 -1.0 1.3 0.7 -1.1
Medication: Cholesterol lowering 0.6 0.9 4.3 0.4 -2.1 -0.3 0.0 0.7 -0.4
Depression (self-reported) 0.5 0.6 2.1 -0.3 -0.1 1.4 -0.1 -0.7 0.8
Medication: Lansoprazole 0.8 0.9 3.6 1.1 0.1 -0.3 -0.5 0.5 1.9
Prospective memory result 0.9 1.1 4.1 0.7 -0.2 -0.3 1.2 0.7 2.0
Lung cancer (father) 0.3 0.4 0.8 0.7 -0.1 -0.2 0.7 0.7 0.9
Illnesses of mother 0.4 0.6 1.0 -0.3 1.0 0.6 -0.5 -0.8 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 8.3 2.9 0.1 -1.6 -1.4 2.2 -0.1
Pulse wave Arterial Stiffness index 0.8 1.0 3.3 0.7 -1.8 -0.4 0.4 0.1 1.3
Impedance of arm (left) 1.7 7.7 12.7 -3.6 -0.7 2.9 3.0 -3.0 2.5
Arm fat mass (right) 0.1 0.2 0.8 -0.1 0.9 -0.0 -0.6 0.2 -0.2
Trunk predicted mass 1.1 6.3 15.3 3.9 0.9 -0.1 -2.2 2.4 -3.3
Standing height 0.4 3.8 8.8 2.6 0.4 3.0 -0.8 0.4 -2.5
Length of working week for main job 2.6 2.9 5.0 1.1 1.8 -1.1 -1.9 1.7 2.2
Exposure to tobacco smoke at home 0.4 0.4 1.4 -0.9 0.1 0.4 0.2 -1.2 0.2
Breastfed as a baby 0.4 0.4 1.4 -0.0 -1.2 0.1 -0.9 0.0 -0.7
Tense / ‘highly strung’ 0.3 0.4 1.4 0.9 -0.5 -0.3 -0.0 1.2 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 6.2 1.4 -0.4 2.5 0.7 1.4 0.2
Hair/balding pattern: Pattern 4 0.2 0.5 1.3 -0.4 0.9 -0.2 -1.2 0.7 0.2
Birth weight of first child 0.6 1.1 2.1 1.4 -0.5 -0.7 0.4 1.4 -1.4
Peak expiratory flow (PEF) 7.3 16.9 44.2 6.6 0.8 -3.5 -3.4 5.5 1.4
Pulse wave reflection index 0.7 0.9 2.6 0.8 -1.6 -0.3 0.6 0.8 1.0
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.7 0.8 0.1 -0.8 0.7 0.7 0.1
Loud music exposure frequency 0.8 0.8 3.2 -0.8 0.8 0.2 0.5 -0.5 1.8
Qualifications: O levels/GCSEs or equivalent 1.3 2.0 4.8 0.2 2.2 2.2 -0.2 -1.5 -0.1
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.9 -0.4 -0.1 0.9 0.1 0.4 1.4
Blood clot in the leg (DVT) 0.6 0.7 2.9 0.1 -1.7 0.4 0.9 -0.0 0.7
Medication: Paracetamol 1.3 2.1 5.2 0.9 -1.2 -2.3 -0.6 1.2 1.8
Headache pain in last month 0.7 1.1 2.4 0.6 -1.6 0.1 1.3 1.3 0.8
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 5.9 -0.3 2.4 -0.3 -1.3 -0.4 0.9
Glaucoma (self-reported) 0.6 0.7 2.5 0.2 -0.6 0.2 1.6 -0.1 -1.1
Gout (self-reported) 1.1 1.6 4.1 -0.6 0.1 -2.0 -2.0 -0.8 0.7
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.8 1.4 1.0 1.3 -0.4 1.2 -0.5
Medication: Amlodipine 1.0 1.3 4.0 -0.4 1.3 -1.5 -0.3 0.2 2.0
Medication: Ventolin 100micrograms inhaler 1.7 2.2 6.8 0.4 -1.1 2.6 1.4 -1.2 -1.3
Birth weight 1.4 3.0 8.7 -1.1 1.0 -2.2 -2.9 0.5 -1.4
Chronic bronchitis/emphysema (mother) 0.6 0.7 2.2 -0.7 -1.5 0.7 -0.3 0.2 1.1
High blood pressure (siblings) 0.1 0.2 0.5 -0.3 -0.4 0.7 0.1 -0.1 -0.2
Forced vital capacity (FVC), Best measure 0.3 1.2 4.8 2.2 -0.2 -0.7 -0.5 1.3 0.0
Body fat percentage 0.2 0.8 1.6 -1.2 1.2 0.5 -0.4 -0.9 0.7
Leg fat percentage (right) 0.4 1.4 4.9 -0.0 2.2 0.8 -1.6 -0.5 -0.3
Arm fat-free mass (right) 1.0 5.2 13.2 3.6 0.7 -0.7 -2.3 2.6 -2.2
Exposure to tobacco smoke outside home 0.5 0.7 2.3 -1.0 -0.4 -0.6 -0.1 -0.4 -1.5
Comparative body size at age 10 0.7 2.0 5.3 -2.0 0.8 -2.3 -0.9 -1.0 0.5
Number of full brothers 1.3 1.6 4.1 -1.2 0.3 -2.0 -0.8 0.5 1.8
Worry too long after embarrassment 0.9 1.5 3.1 1.6 -1.7 0.8 1.0 1.1 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.3 0.6 -0.1 1.2 -0.0 -0.1 -0.4
Wheeze or whistling in the chest in last year 2.7 4.8 16.5 -4.1 0.2 0.9 1.7 -2.8 -0.6
Number of children fathered 2.0 2.3 6.6 1.1 1.6 0.1 -2.6 -0.2 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.1 -0.3 -0.3 -0.2 0.8 -0.1 -1.0
Age at first live birth 0.2 0.4 1.5 0.2 -0.0 0.6 0.3 -1.2 -0.7
Pulse wave peak to peak time 0.9 1.1 3.4 -0.4 1.9 0.7 -0.4 -0.1 -1.5
Health satisfaction 1.0 1.3 5.6 0.6 -0.6 -2.4 -0.3 0.9 0.7
Shortness of breath walking on level ground 1.1 1.3 2.9 -1.1 0.7 -0.5 0.3 -1.7 -1.7
Qualifications: College or University degree 0.2 0.8 2.4 0.9 -0.5 -0.9 1.5 -0.2 -0.4
Eye problems/disorders: None of the above 1.2 1.4 5.2 0.5 0.7 2.3 0.4 -0.2 1.5
Mouth/teeth dental problems: Loose teeth 0.9 1.1 3.5 -0.6 1.0 -0.7 -1.9 -1.0 0.3
Emphysema/chronic bronchitis 0.3 0.4 1.5 -0.5 -1.2 0.3 -0.1 0.4 0.4
Medication for pain relief, constipation, heartburn 0.9 1.5 4.0 -0.7 2.0 1.3 -0.6 -1.5 -0.6
Neck or shoulder pain in last month 1.0 1.4 6.2 1.0 -0.9 0.4 0.1 2.5 -0.2
Medication: Blood pressure 0.6 1.1 3.4 -0.1 -1.8 -0.0 1.6 0.4 -0.5
Angina (self-reported) 1.7 2.2 4.9 1.5 0.8 -1.1 -0.5 2.2 1.9
Migraine (self-reported) 2.0 2.5 8.6 0.3 -2.1 -2.9 -0.3 0.9 0.9
Medication: Ibuprofen 1.2 1.5 3.3 0.1 -1.4 -1.3 1.3 -0.3 -1.8
Medication: Allopurinol 0.9 1.1 3.6 -0.8 -0.1 -1.9 -1.4 -0.4 -0.6
Medication: Omeprazole 1.3 1.5 3.7 0.1 -0.3 1.5 1.9 0.6 -1.6
Medication: Seretide 50 evohaler 0.7 0.8 3.2 -1.1 0.6 -0.3 -0.1 -0.3 1.8
Mean time to correctly identify matches 0.3 0.6 1.3 -0.8 1.1 0.9 0.7 -0.7 -0.0
Heart disease (mother) 1.8 2.2 5.4 1.2 -2.3 0.1 2.0 1.5 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.1 -0.1 -0.2 -0.9 -0.0 0.3 1.1
Whole body fat mass 0.1 0.3 1.0 -0.3 1.0 0.2 -0.7 -0.2 -0.0
Leg fat mass (right) 0.2 0.7 1.7 0.3 1.3 0.4 -1.3 -0.0 -0.6
Arm predicted mass (right) 1.0 5.1 13.4 3.7 0.9 -0.6 -2.2 2.5 -2.2
Pulse rate, automated reading 1.1 3.6 9.5 -2.4 -1.2 -3.1 -1.4 0.0 1.7
Alcohol intake frequency. 0.5 1.1 5.3 -0.6 0.0 -0.4 -2.3 0.5 -0.8
Comparative height size at age 10 0.5 2.8 8.1 2.8 -0.1 0.8 -1.1 1.8 -2.0
Number of full sisters 0.8 1.0 2.6 0.5 0.4 -0.5 -1.6 1.6 0.5
Suffer from ‘nerves’ 0.9 1.4 3.7 1.2 -1.1 1.9 -0.0 1.4 -0.3
Overall health rating 0.5 1.0 3.0 0.5 0.3 -0.7 0.2 1.7 1.5
Chest pain or discomfort 0.5 0.8 3.0 1.0 0.3 0.6 -0.2 1.7 0.2
Had major operations 0.3 0.3 1.5 -0.4 0.3 -1.2 -0.0 0.1 -0.1
Age at last live birth 0.2 0.3 1.1 0.5 0.3 -0.1 0.3 -0.3 -1.0
Family relationship satisfaction 1.3 1.6 6.7 2.6 0.7 0.7 -0.2 1.4 -0.3
Leg pain on walking 0.9 1.1 1.7 -1.3 1.3 0.3 -0.8 -1.2 1.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 0.5 0.5 0.1 -0.1 -0.3 0.2
Commuting to job workplace: Car/motor vehicle 0.4 0.5 2.1 0.3 -0.7 1.4 0.5 0.0 -0.3
Illness, injury, bereavement, stress in last 2 years 0.9 1.2 3.4 -1.9 -0.3 -0.2 -1.1 -1.4 0.5
Medication: Aspirin 2.2 3.0 6.3 0.5 -1.8 -2.5 0.4 1.9 2.1
Supplements: Vitamin C 0.6 0.7 1.9 1.4 0.0 0.5 -1.0 0.5 -0.9
Knee pain experienced in last month 0.3 0.5 2.3 -0.3 1.5 0.1 -0.3 -0.7 0.4
Hypertension (Self-reported) 0.8 2.3 8.5 -0.6 -2.9 0.2 1.5 0.5 1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.2 -0.0 -0.9 0.5 -1.0 1.1 -0.7
Illnesses of father: Heart disease 0.2 0.3 0.8 -0.0 0.4 0.3 -0.9 -0.7 -0.5
Illnesses of siblings: Diabetes 0.4 0.5 1.1 0.5 0.3 -0.6 -1.1 0.9 -0.1
Smoking status: Previous 0.9 1.3 3.3 0.4 0.6 -0.9 -1.5 1.0 1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.4 1.5 1.6 -0.4 -0.6 0.4 0.2
Whole body fat-free mass 0.7 3.9 9.1 3.0 0.5 -0.6 -1.6 2.0 -2.7
Leg fat-free mass (right) 0.3 1.6 3.3 1.8 -0.3 -1.0 -0.5 1.3 -1.8
Arm fat percentage (left) 0.2 0.9 3.2 -1.8 0.6 -0.3 0.0 -0.8 1.0
Average weekly red wine intake 0.2 0.3 0.7 0.7 -0.1 0.3 -0.2 0.5 0.8
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.9 0.2 0.7 -0.3 0.2 -0.9 0.2
Mood swings 1.1 2.0 6.2 2.2 -0.1 -0.9 -0.5 2.5 0.5
Loneliness, isolation 0.6 0.9 2.5 1.1 0.5 1.1 0.2 1.6 -0.4
Long-standing illness, disability or infirmity 0.6 0.9 2.4 0.8 -0.7 0.6 1.5 1.3 0.4
Ever had bowel cancer screening 0.4 0.5 1.3 -1.0 -0.2 0.5 -0.5 -1.2 -0.5
Diabetes diagnosed by doctor 0.6 1.0 3.2 1.8 -0.0 -0.1 0.4 1.7 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.2 -0.2 -0.6 0.9 1.3 -0.4 -1.5
Friendships satisfaction 1.2 1.5 4.2 1.9 -0.2 0.2 -0.9 2.1 -0.3
Qualifications: nursing, teaching 0.8 1.2 3.0 0.3 -1.4 1.4 1.7 0.4 0.0
Commuting to job workplace: Walk 2.3 2.5 5.5 -2.4 1.6 -0.8 -1.5 -2.0 0.0
Eye problems/disorders: Cataract 0.6 0.7 2.1 -0.6 -0.2 -1.5 -1.2 0.5 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 5.8 1.6 -0.5 -0.2 -0.6 2.4 -0.1
Medication for cholesterol 1.0 1.5 6.2 0.4 -0.8 0.3 1.5 -0.1 -2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.0 -0.4 0.9 -0.2 -1.4 0.3 0.8
Back pain experienced in last month 0.7 1.1 2.3 -1.5 1.5 0.2 -0.2 -1.3 0.2
Mineral and other dietary supplements 0.5 0.7 2.7 0.5 1.0 -0.2 0.6 -0.1 1.6
Breast cancer (self-reported) 0.4 0.5 2.4 0.6 -0.5 0.1 0.3 0.0 1.5
Asthma (self-reported) 3.5 6.9 13.1 -2.7 -0.4 3.6 3.0 -3.4 -0.4
Osteoporosis (self-reported) 0.6 0.7 1.8 0.8 -0.5 0.8 0.5 1.3 0.8
Osteoarthritis (self-reported) 0.5 0.6 2.4 -1.0 -0.0 -0.1 -0.4 -1.6 -0.5
Medication: Aspirin 2.0 2.7 4.5 0.4 -2.0 -2.1 0.6 1.6 2.1
Medication: Gliclazide 0.9 1.0 3.2 1.1 -1.8 -0.4 0.9 0.6 -0.2
Illnesses of father: None of the above (group 1) 0.4 0.5 2.3 0.4 -0.1 -0.7 -0.3 1.5 -0.1
Smoking status: Current 0.3 0.5 1.8 0.2 -0.0 -0.9 0.6 -0.0 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 4.0 1.4 -0.2 -1.7 -2.0 1.1 0.6
Whole body water mass 0.7 4.0 9.2 3.0 0.5 -0.7 -1.6 2.0 -2.7
Leg predicted mass (right) 0.3 1.7 3.5 1.9 -0.3 -1.1 -0.6 1.4 -1.8
Arm fat mass (left) 0.1 0.3 1.4 -0.2 1.2 -0.2 -0.8 0.2 0.1
Number of self-reported non-cancer illnesses 0.4 0.8 2.4 -0.3 -1.5 0.6 1.1 0.1 0.7
Average weekly champagne plus white wine intake 0.4 0.5 2.4 0.4 -0.2 0.0 1.6 -0.5 0.2
Miserableness 1.7 2.9 5.3 2.3 -0.2 2.1 0.3 2.1 1.8
Guilty feelings 1.1 1.6 5.0 2.2 -0.9 0.9 0.9 1.4 -0.6
Wears glasses or contact lenses 2.0 2.3 6.1 -2.5 -0.7 -0.8 1.0 -2.2 -0.6
Ever taken oral contraceptive pill 0.3 0.4 1.1 -0.8 -0.2 -0.0 -0.5 -0.2 -1.1
Hearing aid user 0.3 0.3 0.9 -0.7 0.0 0.4 0.6 0.3 1.0
Mother’s age at death 0.1 0.1 0.3 -0.5 0.4 0.2 0.4 -0.3 0.3
Financial situation satisfaction 0.4 0.5 0.9 0.7 0.7 0.9 -0.1 -0.6 -0.7
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.4 0.1 0.1 -0.7 -0.2 1.2 -0.4
Commuting to job workplace: Public transport 0.5 0.6 2.1 -0.7 -0.7 -1.4 -0.1 -0.4 0.4
Eye problems/disorders: Glaucoma 0.5 0.6 2.1 0.0 -0.4 0.2 1.4 -0.2 -1.0
Medication: Blood pressure 0.5 1.0 3.8 -0.6 -1.2 0.1 0.2 0.2 1.9
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.6 0.1 0.2 -1.3 -1.0 1.0 0.8
Supplements: Fish oil (including cod liver oil) 1.0 1.3 5.3 -0.8 -1.2 0.2 -0.6 0.4 -2.3
High cholesterol (Self-reported) 0.3 0.5 1.5 -0.8 -1.2 0.1 -0.7 -0.1 -0.1
Medication: Bendroflumethiazide 0.7 1.1 4.4 -0.6 -0.9 -0.6 2.1 0.2 0.8
Medication: Paracetamol 1.6 2.4 7.8 0.4 -1.4 -2.8 -0.6 0.8 2.0
Medication: Lisinopril 0.3 0.4 1.9 -0.4 -0.3 0.4 1.4 -0.4 -0.3
Medication: Atorvastatin 1.4 1.7 3.3 0.4 -1.4 0.3 -1.8 1.5 1.6
Illnesses of father: High blood pressure 0.4 0.5 1.6 0.4 -0.3 1.3 0.6 -0.5 0.8
Alcohol drinker status: Never 0.3 0.3 0.8 -0.7 -0.9 0.0 -0.7 0.1 -0.4
Ever smoked 0.2 0.3 1.0 -0.1 0.8 -0.2 -0.1 -0.5 -1.0
Basal metabolic rate 0.6 3.2 7.6 2.8 0.8 -0.3 -1.6 1.8 -2.2
Leg fat percentage (left) 0.4 1.3 4.6 0.1 2.1 0.7 -1.6 -0.4 -0.2
Arm fat-free mass (left) 1.1 5.5 14.1 3.8 1.3 -0.5 -2.3 2.6 -2.3
Number of operations (self-reported) 0.2 0.3 0.7 -0.8 -0.5 -0.8 0.1 0.1 0.4
Average weekly beer plus cider intake 0.7 1.0 3.0 -1.7 0.7 -1.4 -0.6 0.0 -0.5
Irritability 0.3 0.5 1.1 0.6 0.7 1.1 0.8 0.7 -0.2
Risk taking 0.5 0.7 2.0 -1.0 0.4 -1.4 0.5 -0.8 -0.6
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.1 -0.6 -1.5 -0.0 0.9 -0.9 0.1
Fractured/broken bones in last 5 years 0.6 0.7 2.4 -0.4 -0.4 -0.6 1.1 -0.3 1.5
Age started oral contraceptive pill 1.2 1.4 3.6 -0.8 1.0 -1.9 -1.7 -0.5 -0.5
Diastolic blood pressure, automated reading 0.7 2.1 7.2 0.0 -2.7 0.4 -1.2 -0.7 1.7
Ever depressed for a whole week 2.9 3.5 9.7 3.1 0.8 -0.4 -2.5 2.1 -0.4
Unable to work because of sickness or disability 0.3 0.4 1.6 0.0 -0.0 0.1 -0.5 0.6 -1.3
Commuting to job workplace: Cycle 0.8 1.0 3.6 -1.0 1.0 0.0 -1.9 -0.5 -0.1
Myopia 0.3 0.4 1.4 1.2 -0.6 0.6 0.1 0.5 0.3
Vascular/heart problems diagnosed by doctor 0.3 0.8 3.8 0.7 2.0 -0.1 -0.5 -0.1 -0.7
Cholesterol lowering medication 0.3 0.4 1.4 -0.7 0.2 0.5 -1.2 0.1 0.6
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 6.3 0.2 0.2 1.7 1.9 0.5 -2.5
Pain experienced in last month 0.1 0.2 0.9 0.4 -0.1 -0.2 -0.3 -0.9 -0.4
Supplements: Calcium 0.6 0.7 1.6 0.5 -1.3 0.7 -0.5 1.2 0.3
Basal cell carcinoma (self-reported) 0.6 0.7 1.4 0.1 0.8 -1.2 -1.1 -0.2 -1.0
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.5 0.4 -0.1 -0.6 -0.4 1.2 0.1
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 3.3 0.2 -1.8 0.5 0.8 -0.2 0.4
Heart disease (siblings) 0.1 0.1 0.2 -0.3 0.4 -0.2 -0.4 -0.1 -0.3
Alcohol drinker status: Previous 0.6 0.6 1.4 0.6 -0.4 -1.1 -0.9 1.2 -0.1
Pack years of smoking 1.0 1.4 3.5 -1.9 -0.5 -1.6 -1.4 0.1 -0.2
Impedance of whole body 1.0 4.9 12.6 -1.9 0.4 3.5 1.7 -2.2 2.4
Leg fat mass (left) 0.2 0.7 2.0 0.3 1.3 0.3 -1.4 0.0 -0.5
Arm predicted mass (left) 1.0 5.2 12.0 3.5 1.4 -0.6 -2.5 2.5 -2.1