Hub : Genes

TAB2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0740	0.0300	1.1e-03	0.045	0.025	0.013	0.026	0.034	3.1e-06	0.00044	0.00950	0.00037	4.5e-05
2	GTEx	Cells Transformed fibroblasts	0.2040	0.0540	1.1e-06	0.055	NA	0.048	NA	0.051	6.0e-05	NA	0.00018	NA	1.1e-04
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1470	0.0550	1.4e-03	0.058	NA	0.045	NA	0.049	4.2e-04	NA	0.00160	NA	1.1e-03
4	GTEx	Skin Sun Exposed Lower leg	0.0970	0.0410	6.3e-03	0.001	NA	0.014	NA	0.005	2.8e-01	NA	0.02200	NA	1.1e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.0511	0.0220	3.9e-03	0.001	0.015	0.007	0.014	0.003	2.5e-01	0.00450	0.03400	0.00620	1.3e-01
6	TCGA	Lung Adenocarcinoma	0.0458	0.0238	5.3e-03	0.001	0.013	0.005	NA	0.001	2.2e-01	0.00970	0.08300	NA	2.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.5	0.8	2.4	1.5	-0.1	-0.4	1.0	0.4	-1.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.8	0.9	0.3	-0.1	0.2	0.3	-0.1
Depressed Affect (Nagel 2018)	0.6	1.2	3.4	1.8	0.4	1.4	1.0	1.1	0.1
Depression (Nagel 2018)	1.2	1.7	5.1	2.3	-0.2	1.3	-0.4	1.5	-1.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.4	1.6	-0.8	0.2	-0.5	0.6	-1.5
Neuroticism (Nagel 2018)	1.1	2.7	7.2	2.7	-1.0	1.7	1.6	1.5	-0.4
Schizophrenia (2018)	0.1	0.2	0.7	-0.1	0.4	0.2	-0.6	-0.0	0.9
Schizophrenia vs Biploar Disorder	1.1	1.5	4.4	-1.3	-0.2	1.3	0.7	-2.1	0.6
Worry (Nagel 2018)	0.6	1.2	4.7	2.2	-0.8	1.0	-0.2	0.9	0.5
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	-0.5	0.5	0.0	0.7	-0.7	-0.7
Alzheimer’s Disease (in father)	0.5	0.6	1.2	-0.4	-0.8	-1.1	1.1	0.1	0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	3.0	-1.7	0.4	-1.0	0.6	-1.1	-0.2
Crohns Disease (2017)	0.5	1.0	2.1	-0.5	-1.1	-1.0	0.4	-1.1	-1.4
Irritable Bowel Disease (IBD)	1.3	3.0	9.1	-0.6	0.0	-3.0	-1.2	-1.1	-2.4
Ulcerative Colitis (UC)	1.6	3.0	6.3	-0.6	1.5	-2.5	-1.9	-0.5	-2.3
Major Depression (MDD)	0.8	1.0	5.0	-0.5	0.7	2.2	0.3	-0.4	0.3
Reaction Time	0.4	0.8	1.8	0.4	1.3	1.2	1.0	0.0	-0.1
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.9	1.0	-0.9	1.7	1.2	-0.7	-1.4
Breast Cancer	0.2	0.4	1.1	-0.2	0.5	-0.9	1.0	-0.5	-0.3
Ovarian Cancer	0.7	0.9	4.2	0.0	-0.4	2.1	-0.7	-0.1	-0.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.2	1.8	3.1	-1.4	1.8	0.9	0.6	-1.8	1.2
Bipolar Disorder (2011)	0.4	0.4	0.8	0.3	-0.2	-0.9	0.8	0.9	0.4
Body Mass Index (BMI) (2010)	0.8	1.1	3.4	-1.2	-1.0	-0.5	0.3	0.7	-1.8
Coronary Artery Disease (CAD)	2.4	2.8	11.5	1.2	-0.5	-1.4	0.1	1.3	3.4
Crohns Disease (2012)	0.8	1.3	4.7	0.4	-1.1	0.3	0.7	-1.0	-2.2
Mean Putamen Volume	3.1	3.5	6.0	2.0	-1.3	1.2	2.3	2.4	1.6
Fasting Glucose	0.7	0.8	2.5	0.0	-0.3	-1.6	-1.3	0.7	-0.1
HbA1C	1.3	1.4	5.8	0.2	1.3	0.1	-0.4	-1.0	-2.4
HDL Cholesterol	0.5	0.8	2.2	-0.4	-1.5	0.7	1.2	0.2	-0.8
LDL Cholesterol	0.3	0.5	1.7	0.5	1.1	0.3	-1.3	0.1	-0.0
Lupus	0.3	0.5	1.3	-1.0	0.8	0.3	0.1	-1.1	0.3
Neuroticism (2016)	0.6	0.9	3.0	1.0	0.5	1.7	0.2	0.9	0.3
Primary Biliary Cirrhosis	1.1	1.6	4.8	-2.2	0.9	-0.7	-0.5	-1.7	-0.9
Rheumatoid Arthritis	0.6	0.8	3.3	0.6	1.8	0.6	-0.3	-0.2	-0.8
Schizophrenia (2014)	0.3	0.6	1.8	-0.1	1.0	0.8	-0.3	-1.3	0.3
Triglycerides	1.2	2.0	3.8	-2.0	1.2	-1.5	-1.4	-1.6	0.0
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.5	-1.1	-1.0	-1.6	-1.0	-0.2	0.7
Ulcerative Colitis	1.2	1.8	5.1	-0.5	-0.2	-2.1	-0.6	-0.6	-2.3
Blood Eosinophil Count	1.3	9.8	17.1	-3.6	-1.3	3.7	3.6	-4.1	0.3
Blood Platelet Count	0.2	1.9	4.5	0.1	-2.1	1.8	1.4	-0.2	-1.3
Blood Red Count	0.2	1.8	6.8	-0.2	0.3	-2.6	-0.9	-0.0	1.8
Blood White Count	0.5	4.0	10.3	-2.4	-0.3	0.5	1.7	-2.2	-3.2
Heel T-Score	0.2	1.5	6.5	0.5	-1.0	0.5	0.5	1.0	2.5
BMI	0.1	0.9	3.6	-1.0	0.3	-1.9	0.0	0.4	0.5
Height	0.7	13.7	42.8	6.5	0.2	2.0	-3.5	3.1	-3.6
Waist Hip Ratio (WHR)	0.3	1.2	5.0	2.2	0.6	-0.0	-0.6	0.9	0.9
Systolic Blood Pressure	0.3	1.6	5.0	-1.1	-0.7	0.5	0.3	-1.5	2.2
Smoking Status	0.3	0.6	1.9	1.4	0.0	-0.6	-0.8	0.6	-0.6
Allergy or Eczema	0.4	1.1	2.6	0.0	-1.6	1.2	1.3	0.5	0.9
Cardiovascular Disease	0.8	2.5	6.3	-1.0	-2.5	0.6	1.7	-0.5	2.0
Hypothyroidism (self reported)	0.3	0.6	2.5	0.6	1.6	0.5	-0.6	0.3	0.2
Respiratory disease	3.7	8.3	17.2	-3.5	0.5	4.1	2.5	-3.7	-0.6
Type 2 Diabetes (T2D) (2018)	1.1	2.1	5.9	2.4	-1.0	-0.2	1.0	2.0	-0.8
Lung FEV1/FVC ratio	1.2	5.9	15.7	3.2	1.4	-1.5	-4.0	1.9	-1.3
Lung FVC	0.9	4.3	9.4	1.4	-2.3	-3.1	-0.1	3.0	0.2
Neuroticism	1.0	2.4	6.7	2.6	0.0	2.1	-0.9	1.4	-0.7
Chronotype (morning person)	1.0	2.2	5.4	-1.9	-0.4	1.0	0.9	-1.5	-2.3
Hair Pigment	0.0	0.5	1.6	0.4	-0.2	-0.4	1.3	-0.9	-0.5
Tanning	0.1	1.6	3.2	0.0	0.6	1.7	1.6	-0.7	-1.8
Hand grip strength (left)	0.8	2.1	5.9	-0.0	1.9	-2.4	-1.5	0.6	-0.7
Number of treatments/medications taken	0.8	1.4	6.4	0.1	-2.5	-0.5	0.4	1.1	0.6
Average weekly spirits intake	0.5	0.7	2.8	0.1	1.7	0.2	-0.5	-0.8	-0.6
Sensitivity / hurt feelings	0.9	1.5	2.6	1.6	-0.8	1.2	1.6	1.4	0.0
Frequency of depressed mood in last 2 weeks	2.2	3.0	8.1	2.8	0.7	2.1	0.2	1.7	-1.5
Hearing difficulty/problems: Yes	0.4	0.5	1.4	-0.3	0.1	-1.0	1.2	-0.2	0.8
Relative age of first facial hair	0.7	1.5	5.4	-0.6	-1.1	-1.4	2.3	0.3	-0.2
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	3.5	1.6	1.0	-1.6	0.6	1.2	-1.9
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.1	-0.8	0.1	-1.1	-1.4	-0.3	-0.2
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	0.6	-0.5	0.3	0.1	0.8	0.7
Systolic blood pressure, automated reading	0.6	1.7	3.8	-1.5	-0.4	-0.9	-1.4	-1.0	1.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	3.3	-0.3	-0.8	-1.8	-0.4	0.1	-0.0
Angina	2.1	2.7	5.4	1.6	1.1	-1.3	-0.7	2.3	2.3
Medication for hormone replacement therapy	1.2	1.3	3.8	-0.1	1.0	-0.9	-1.9	-0.3	1.4
Vitamin and mineral supplements	0.7	0.9	3.6	-0.4	1.1	0.5	0.0	0.3	1.9
Supplements: Zinc	1.4	1.5	3.0	0.6	-1.5	1.7	1.4	1.0	-0.8
Medication: Co-codamol	2.3	2.7	8.7	3.0	-0.7	-0.6	0.0	2.5	-0.4
Medication: Metformin	1.0	1.5	4.9	2.2	-0.6	0.9	0.7	1.0	-1.0
Diabetes (father)	0.2	0.2	0.5	0.0	0.6	-0.7	-0.2	0.1	-0.6
Diabetes (mother)	1.1	1.4	4.0	-0.4	-2.0	-1.2	-1.4	0.7	0.5
Severe depression (siblings)	2.5	2.8	10.5	0.2	0.4	3.2	1.7	-0.9	-1.6
Pack years adult smoking proportion	0.8	1.2	2.5	-1.5	-0.6	-1.6	-1.4	0.3	-0.3
Impedance of leg (right)	0.8	3.9	16.3	0.0	2.0	4.0	0.0	-1.3	1.1
Leg fat-free mass (left)	0.3	1.4	3.3	1.6	-0.0	-0.9	-0.6	1.2	-1.8
Trunk fat percentage	0.3	1.1	2.6	-1.6	1.0	0.7	-0.1	-1.2	1.1
Hand grip strength (right)	0.9	2.4	4.6	1.3	2.1	-1.7	-1.5	1.4	-1.1
Townsend deprivation index at recruitment	0.8	1.1	3.5	-0.6	0.1	-1.4	-1.9	0.4	0.8
Current tobacco smoking	0.3	0.5	1.7	-0.1	-0.7	-0.7	0.7	0.0	-1.3
Average weekly fortified wine intake	0.9	1.0	2.2	1.3	-0.7	-1.1	0.7	1.5	-0.2
Maternal smoking around birth	0.5	0.8	2.3	0.7	1.2	-0.8	-1.5	0.2	-0.2
Fed-up feelings	0.6	1.0	2.3	1.5	1.3	1.1	-0.2	0.5	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	1.2	0.3	0.9	-0.3	1.3	-0.9
Relative age voice broke	0.7	1.0	4.7	-0.8	-0.7	-0.6	2.2	-0.4	0.1
Taking other prescription medications	0.8	1.2	2.2	0.7	-0.5	1.5	1.3	0.7	1.4
Age when periods started (menarche)	0.1	0.3	1.2	0.4	-1.1	0.7	-0.1	0.2	-0.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	-1.5	0.5	-1.1	-0.2	-0.4	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	-0.4	-0.7	0.1	0.4	0.1	0.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.6	-1.2	0.1	0.3	-0.9	-1.1	0.7
Qualifications: CSEs or equivalent	0.7	0.9	3.0	0.3	0.4	1.7	1.2	-0.6	0.6
Serious illness, injury or assault to yourself	0.6	0.7	2.0	0.8	-0.2	-1.4	-0.8	1.0	0.2
High blood pressure	0.6	1.8	7.8	-0.5	-2.8	0.5	1.2	0.3	0.9
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.6	0.2	-1.5	0.1	0.9	0.2	1.6
Multivitamins +/- minerals	0.8	1.0	3.3	-0.6	-0.2	0.4	0.9	-1.3	-1.8
Stomach or abdominal pain in last month	0.5	0.6	1.4	0.7	0.3	1.2	1.1	0.8	-0.2
Supplements: Glucosamine	0.7	0.9	1.7	-0.9	-1.3	-0.6	1.0	-0.7	-1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.5	0.3	0.9	-1.6	-0.3	0.8	-0.2
Medication: Atenolol	1.0	1.3	2.6	1.2	0.2	-1.4	-1.6	0.8	0.9
Medication: Levothyroxine sodium	0.4	0.7	2.3	0.1	1.1	1.5	-0.2	-0.2	-0.6
Sitting height	0.2	1.2	3.4	0.0	0.5	-0.3	-1.5	-1.0	-1.8
Chronic bronchitis/emphysema (father)	1.7	2.0	5.7	0.6	-2.4	1.6	1.3	0.3	1.2
High blood pressure (mother)	0.8	1.1	4.7	2.2	-0.5	-0.8	0.2	1.1	-0.0
Body mass index (BMI)	0.1	0.6	1.7	-0.1	0.8	-1.3	-0.7	0.6	-0.0
Impedance of leg (left)	0.7	3.5	15.9	0.5	1.7	4.0	0.0	-0.9	1.1
Leg predicted mass (left)	0.2	1.3	2.8	1.5	-0.0	-0.9	-0.6	1.2	-1.7
Trunk fat mass	0.1	0.4	1.0	-0.6	1.0	0.5	-0.7	-0.6	0.1
Waist circumference	0.1	0.5	1.6	0.8	0.4	0.4	-0.5	0.5	-1.3
Number of incorrect matches in round	1.5	2.5	6.3	-1.5	1.2	1.2	-1.1	-1.4	-2.5
Past tobacco smoking	0.4	0.8	1.8	-0.5	-1.3	0.9	1.1	-0.5	-0.7
Alcohol usually taken with meals	0.3	0.4	1.3	0.4	-0.4	-0.5	-0.6	0.7	-1.1
Nervous feelings	0.3	0.5	2.0	0.9	0.2	0.6	0.1	0.1	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.5	1.2	0.6	1.1	-0.6	1.6	0.4
Hearing difficulty/problems with background noise	0.7	1.1	2.8	1.2	-1.7	0.3	1.2	0.8	0.0
Hair/balding pattern: Pattern 2	2.0	2.6	8.2	1.2	-2.9	-0.3	1.6	1.2	1.2
Had menopause	1.8	2.2	4.3	-2.1	-1.3	1.1	-0.0	-1.5	-1.9
Had other major operations	0.4	0.5	1.3	-0.1	0.1	-0.7	0.6	0.8	1.2
Forced vital capacity (FVC)	0.4	1.5	6.0	2.5	-0.3	-0.5	-0.0	1.7	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	-0.3	-0.3	-0.2	-0.2	0.4	0.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.0	1.4	1.3	1.4	-0.5	0.7	-0.0
Qualifications: None of the above	0.8	1.6	4.6	-1.1	-0.4	-1.5	-2.1	1.0	0.8
Financial difficulties in last 2 years	0.9	1.2	3.3	1.5	0.7	1.8	0.6	0.9	-0.1
Mouth/teeth dental problems	0.3	0.4	0.9	1.0	0.3	0.7	0.7	-0.3	-0.6
Heart attack	0.2	0.3	1.0	0.2	0.2	-0.7	-0.1	1.0	0.2
Allergy	1.7	3.8	6.4	2.0	2.1	-1.6	-2.5	2.0	-1.3
Pain all over the body in last month	0.6	0.6	3.0	-0.4	0.7	0.4	0.0	0.4	-1.7
Diabetes (self-reported)	0.9	1.3	3.1	1.8	-1.1	-0.6	0.8	1.7	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	0.5	-0.3	0.7	0.6	-0.1	0.7
Medication: Ramipril	1.2	1.5	5.8	-0.4	-2.4	0.4	0.6	0.7	1.5
Medication: Simvastatin	0.6	0.9	3.1	0.3	-1.8	1.0	0.0	0.2	-1.0
Fluid intelligence score	0.4	0.9	3.8	1.9	-0.5	0.3	0.6	0.3	-1.0
Illnesses of siblings	0.4	0.6	1.5	1.2	-0.1	-1.2	-0.0	0.5	0.6
Neuroticism score	1.0	2.2	7.9	2.8	-0.5	1.0	-0.1	2.0	-0.0
Weight	0.2	0.9	1.3	1.1	1.1	0.0	-1.1	0.7	-1.2
Impedance of arm (right)	1.4	6.7	11.2	-3.3	-0.3	3.0	2.7	-2.8	2.3
Arm fat percentage (right)	0.2	0.7	2.5	-1.6	0.6	-0.1	-0.1	-0.6	0.9
Trunk fat-free mass	1.1	6.2	15.2	3.9	0.9	-0.1	-2.2	2.4	-3.3
Hip circumference	0.4	1.6	5.6	1.1	0.2	1.5	0.1	0.6	-2.4
Time employed in main current job	1.0	1.1	3.2	-1.3	1.8	-0.0	-0.7	-0.9	0.7
Alcohol intake versus 10 years previously	0.4	0.5	1.7	0.8	1.3	-0.7	-0.1	0.6	0.2
Father’s age at death	0.5	0.7	2.4	-0.3	-0.5	0.8	1.6	-0.0	0.8
Worrier / anxious feelings	1.2	2.3	6.9	1.9	-0.9	0.3	-0.2	1.5	2.6
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.5	1.6	1.3	0.8	-0.6	1.3	0.4
Falls in the last year	0.2	0.3	0.6	-0.8	-0.6	0.7	0.6	-0.1	0.4
Hair/balding pattern: Pattern 3	0.6	0.9	1.7	-0.6	0.6	1.3	0.7	-1.3	-0.9
Number of live births	1.6	2.3	8.4	-2.9	0.8	-0.7	-0.6	-1.9	0.4
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	10.5	3.2	0.2	-1.0	-1.2	2.4	0.6
Pulse rate	1.1	1.9	3.7	1.6	-1.9	-0.7	-1.7	1.1	0.5
Happiness	2.7	3.3	10.3	3.2	-1.5	0.8	0.3	2.4	-0.7
Noisy workplace	0.7	0.8	1.7	0.4	-1.2	0.9	-1.3	1.0	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.2	1.1	-0.4	0.6	-0.2	-0.0	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.9	1.7	0.6	-0.9	1.5	1.0	-1.0
Mouth/teeth dental problems: Dentures	1.3	2.2	5.8	-2.4	0.2	-1.5	-1.7	-1.4	0.1
Asthma	3.7	7.4	12.9	-2.9	-0.6	3.4	3.3	-3.6	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.3	2.7	0.9	-1.6	-1.0	1.3	0.7	-1.1
Medication: Cholesterol lowering	0.6	0.9	4.3	0.4	-2.1	-0.3	0.0	0.7	-0.4
Depression (self-reported)	0.5	0.6	2.1	-0.3	-0.1	1.4	-0.1	-0.7	0.8
Medication: Lansoprazole	0.8	0.9	3.6	1.1	0.1	-0.3	-0.5	0.5	1.9
Prospective memory result	0.9	1.1	4.1	0.7	-0.2	-0.3	1.2	0.7	2.0
Lung cancer (father)	0.3	0.4	0.8	0.7	-0.1	-0.2	0.7	0.7	0.9
Illnesses of mother	0.4	0.6	1.0	-0.3	1.0	0.6	-0.5	-0.8	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	8.3	2.9	0.1	-1.6	-1.4	2.2	-0.1
Pulse wave Arterial Stiffness index	0.8	1.0	3.3	0.7	-1.8	-0.4	0.4	0.1	1.3
Impedance of arm (left)	1.7	7.7	12.7	-3.6	-0.7	2.9	3.0	-3.0	2.5
Arm fat mass (right)	0.1	0.2	0.8	-0.1	0.9	-0.0	-0.6	0.2	-0.2
Trunk predicted mass	1.1	6.3	15.3	3.9	0.9	-0.1	-2.2	2.4	-3.3
Standing height	0.4	3.8	8.8	2.6	0.4	3.0	-0.8	0.4	-2.5
Length of working week for main job	2.6	2.9	5.0	1.1	1.8	-1.1	-1.9	1.7	2.2
Exposure to tobacco smoke at home	0.4	0.4	1.4	-0.9	0.1	0.4	0.2	-1.2	0.2
Breastfed as a baby	0.4	0.4	1.4	-0.0	-1.2	0.1	-0.9	0.0	-0.7
Tense / ‘highly strung’	0.3	0.4	1.4	0.9	-0.5	-0.3	-0.0	1.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	6.2	1.4	-0.4	2.5	0.7	1.4	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	-0.4	0.9	-0.2	-1.2	0.7	0.2
Birth weight of first child	0.6	1.1	2.1	1.4	-0.5	-0.7	0.4	1.4	-1.4
Peak expiratory flow (PEF)	7.3	16.9	44.2	6.6	0.8	-3.5	-3.4	5.5	1.4
Pulse wave reflection index	0.7	0.9	2.6	0.8	-1.6	-0.3	0.6	0.8	1.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	0.8	0.1	-0.8	0.7	0.7	0.1
Loud music exposure frequency	0.8	0.8	3.2	-0.8	0.8	0.2	0.5	-0.5	1.8
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	4.8	0.2	2.2	2.2	-0.2	-1.5	-0.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.9	-0.4	-0.1	0.9	0.1	0.4	1.4
Blood clot in the leg (DVT)	0.6	0.7	2.9	0.1	-1.7	0.4	0.9	-0.0	0.7
Medication: Paracetamol	1.3	2.1	5.2	0.9	-1.2	-2.3	-0.6	1.2	1.8
Headache pain in last month	0.7	1.1	2.4	0.6	-1.6	0.1	1.3	1.3	0.8
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	5.9	-0.3	2.4	-0.3	-1.3	-0.4	0.9
Glaucoma (self-reported)	0.6	0.7	2.5	0.2	-0.6	0.2	1.6	-0.1	-1.1
Gout (self-reported)	1.1	1.6	4.1	-0.6	0.1	-2.0	-2.0	-0.8	0.7
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.8	1.4	1.0	1.3	-0.4	1.2	-0.5
Medication: Amlodipine	1.0	1.3	4.0	-0.4	1.3	-1.5	-0.3	0.2	2.0
Medication: Ventolin 100micrograms inhaler	1.7	2.2	6.8	0.4	-1.1	2.6	1.4	-1.2	-1.3
Birth weight	1.4	3.0	8.7	-1.1	1.0	-2.2	-2.9	0.5	-1.4
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.2	-0.7	-1.5	0.7	-0.3	0.2	1.1
High blood pressure (siblings)	0.1	0.2	0.5	-0.3	-0.4	0.7	0.1	-0.1	-0.2
Forced vital capacity (FVC), Best measure	0.3	1.2	4.8	2.2	-0.2	-0.7	-0.5	1.3	0.0
Body fat percentage	0.2	0.8	1.6	-1.2	1.2	0.5	-0.4	-0.9	0.7
Leg fat percentage (right)	0.4	1.4	4.9	-0.0	2.2	0.8	-1.6	-0.5	-0.3
Arm fat-free mass (right)	1.0	5.2	13.2	3.6	0.7	-0.7	-2.3	2.6	-2.2
Exposure to tobacco smoke outside home	0.5	0.7	2.3	-1.0	-0.4	-0.6	-0.1	-0.4	-1.5
Comparative body size at age 10	0.7	2.0	5.3	-2.0	0.8	-2.3	-0.9	-1.0	0.5
Number of full brothers	1.3	1.6	4.1	-1.2	0.3	-2.0	-0.8	0.5	1.8
Worry too long after embarrassment	0.9	1.5	3.1	1.6	-1.7	0.8	1.0	1.1	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.3	0.6	-0.1	1.2	-0.0	-0.1	-0.4
Wheeze or whistling in the chest in last year	2.7	4.8	16.5	-4.1	0.2	0.9	1.7	-2.8	-0.6
Number of children fathered	2.0	2.3	6.6	1.1	1.6	0.1	-2.6	-0.2	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.1	-0.3	-0.3	-0.2	0.8	-0.1	-1.0
Age at first live birth	0.2	0.4	1.5	0.2	-0.0	0.6	0.3	-1.2	-0.7
Pulse wave peak to peak time	0.9	1.1	3.4	-0.4	1.9	0.7	-0.4	-0.1	-1.5
Health satisfaction	1.0	1.3	5.6	0.6	-0.6	-2.4	-0.3	0.9	0.7
Shortness of breath walking on level ground	1.1	1.3	2.9	-1.1	0.7	-0.5	0.3	-1.7	-1.7
Qualifications: College or University degree	0.2	0.8	2.4	0.9	-0.5	-0.9	1.5	-0.2	-0.4
Eye problems/disorders: None of the above	1.2	1.4	5.2	0.5	0.7	2.3	0.4	-0.2	1.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.5	-0.6	1.0	-0.7	-1.9	-1.0	0.3
Emphysema/chronic bronchitis	0.3	0.4	1.5	-0.5	-1.2	0.3	-0.1	0.4	0.4
Medication for pain relief, constipation, heartburn	0.9	1.5	4.0	-0.7	2.0	1.3	-0.6	-1.5	-0.6
Neck or shoulder pain in last month	1.0	1.4	6.2	1.0	-0.9	0.4	0.1	2.5	-0.2
Medication: Blood pressure	0.6	1.1	3.4	-0.1	-1.8	-0.0	1.6	0.4	-0.5
Angina (self-reported)	1.7	2.2	4.9	1.5	0.8	-1.1	-0.5	2.2	1.9
Migraine (self-reported)	2.0	2.5	8.6	0.3	-2.1	-2.9	-0.3	0.9	0.9
Medication: Ibuprofen	1.2	1.5	3.3	0.1	-1.4	-1.3	1.3	-0.3	-1.8
Medication: Allopurinol	0.9	1.1	3.6	-0.8	-0.1	-1.9	-1.4	-0.4	-0.6
Medication: Omeprazole	1.3	1.5	3.7	0.1	-0.3	1.5	1.9	0.6	-1.6
Medication: Seretide 50 evohaler	0.7	0.8	3.2	-1.1	0.6	-0.3	-0.1	-0.3	1.8
Mean time to correctly identify matches	0.3	0.6	1.3	-0.8	1.1	0.9	0.7	-0.7	-0.0
Heart disease (mother)	1.8	2.2	5.4	1.2	-2.3	0.1	2.0	1.5	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.1	-0.1	-0.2	-0.9	-0.0	0.3	1.1
Whole body fat mass	0.1	0.3	1.0	-0.3	1.0	0.2	-0.7	-0.2	-0.0
Leg fat mass (right)	0.2	0.7	1.7	0.3	1.3	0.4	-1.3	-0.0	-0.6
Arm predicted mass (right)	1.0	5.1	13.4	3.7	0.9	-0.6	-2.2	2.5	-2.2
Pulse rate, automated reading	1.1	3.6	9.5	-2.4	-1.2	-3.1	-1.4	0.0	1.7
Alcohol intake frequency.	0.5	1.1	5.3	-0.6	0.0	-0.4	-2.3	0.5	-0.8
Comparative height size at age 10	0.5	2.8	8.1	2.8	-0.1	0.8	-1.1	1.8	-2.0
Number of full sisters	0.8	1.0	2.6	0.5	0.4	-0.5	-1.6	1.6	0.5
Suffer from ‘nerves’	0.9	1.4	3.7	1.2	-1.1	1.9	-0.0	1.4	-0.3
Overall health rating	0.5	1.0	3.0	0.5	0.3	-0.7	0.2	1.7	1.5
Chest pain or discomfort	0.5	0.8	3.0	1.0	0.3	0.6	-0.2	1.7	0.2
Had major operations	0.3	0.3	1.5	-0.4	0.3	-1.2	-0.0	0.1	-0.1
Age at last live birth	0.2	0.3	1.1	0.5	0.3	-0.1	0.3	-0.3	-1.0
Family relationship satisfaction	1.3	1.6	6.7	2.6	0.7	0.7	-0.2	1.4	-0.3
Leg pain on walking	0.9	1.1	1.7	-1.3	1.3	0.3	-0.8	-1.2	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.5	0.5	0.1	-0.1	-0.3	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.1	0.3	-0.7	1.4	0.5	0.0	-0.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	3.4	-1.9	-0.3	-0.2	-1.1	-1.4	0.5
Medication: Aspirin	2.2	3.0	6.3	0.5	-1.8	-2.5	0.4	1.9	2.1
Supplements: Vitamin C	0.6	0.7	1.9	1.4	0.0	0.5	-1.0	0.5	-0.9
Knee pain experienced in last month	0.3	0.5	2.3	-0.3	1.5	0.1	-0.3	-0.7	0.4
Hypertension (Self-reported)	0.8	2.3	8.5	-0.6	-2.9	0.2	1.5	0.5	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.2	-0.0	-0.9	0.5	-1.0	1.1	-0.7
Illnesses of father: Heart disease	0.2	0.3	0.8	-0.0	0.4	0.3	-0.9	-0.7	-0.5
Illnesses of siblings: Diabetes	0.4	0.5	1.1	0.5	0.3	-0.6	-1.1	0.9	-0.1
Smoking status: Previous	0.9	1.3	3.3	0.4	0.6	-0.9	-1.5	1.0	1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.4	1.5	1.6	-0.4	-0.6	0.4	0.2
Whole body fat-free mass	0.7	3.9	9.1	3.0	0.5	-0.6	-1.6	2.0	-2.7
Leg fat-free mass (right)	0.3	1.6	3.3	1.8	-0.3	-1.0	-0.5	1.3	-1.8
Arm fat percentage (left)	0.2	0.9	3.2	-1.8	0.6	-0.3	0.0	-0.8	1.0
Average weekly red wine intake	0.2	0.3	0.7	0.7	-0.1	0.3	-0.2	0.5	0.8
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.9	0.2	0.7	-0.3	0.2	-0.9	0.2
Mood swings	1.1	2.0	6.2	2.2	-0.1	-0.9	-0.5	2.5	0.5
Loneliness, isolation	0.6	0.9	2.5	1.1	0.5	1.1	0.2	1.6	-0.4
Long-standing illness, disability or infirmity	0.6	0.9	2.4	0.8	-0.7	0.6	1.5	1.3	0.4
Ever had bowel cancer screening	0.4	0.5	1.3	-1.0	-0.2	0.5	-0.5	-1.2	-0.5
Diabetes diagnosed by doctor	0.6	1.0	3.2	1.8	-0.0	-0.1	0.4	1.7	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.2	-0.2	-0.6	0.9	1.3	-0.4	-1.5
Friendships satisfaction	1.2	1.5	4.2	1.9	-0.2	0.2	-0.9	2.1	-0.3
Qualifications: nursing, teaching	0.8	1.2	3.0	0.3	-1.4	1.4	1.7	0.4	0.0
Commuting to job workplace: Walk	2.3	2.5	5.5	-2.4	1.6	-0.8	-1.5	-2.0	0.0
Eye problems/disorders: Cataract	0.6	0.7	2.1	-0.6	-0.2	-1.5	-1.2	0.5	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	5.8	1.6	-0.5	-0.2	-0.6	2.4	-0.1
Medication for cholesterol	1.0	1.5	6.2	0.4	-0.8	0.3	1.5	-0.1	-2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.0	-0.4	0.9	-0.2	-1.4	0.3	0.8
Back pain experienced in last month	0.7	1.1	2.3	-1.5	1.5	0.2	-0.2	-1.3	0.2
Mineral and other dietary supplements	0.5	0.7	2.7	0.5	1.0	-0.2	0.6	-0.1	1.6
Breast cancer (self-reported)	0.4	0.5	2.4	0.6	-0.5	0.1	0.3	0.0	1.5
Asthma (self-reported)	3.5	6.9	13.1	-2.7	-0.4	3.6	3.0	-3.4	-0.4
Osteoporosis (self-reported)	0.6	0.7	1.8	0.8	-0.5	0.8	0.5	1.3	0.8
Osteoarthritis (self-reported)	0.5	0.6	2.4	-1.0	-0.0	-0.1	-0.4	-1.6	-0.5
Medication: Aspirin	2.0	2.7	4.5	0.4	-2.0	-2.1	0.6	1.6	2.1
Medication: Gliclazide	0.9	1.0	3.2	1.1	-1.8	-0.4	0.9	0.6	-0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	2.3	0.4	-0.1	-0.7	-0.3	1.5	-0.1
Smoking status: Current	0.3	0.5	1.8	0.2	-0.0	-0.9	0.6	-0.0	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.0	1.4	-0.2	-1.7	-2.0	1.1	0.6
Whole body water mass	0.7	4.0	9.2	3.0	0.5	-0.7	-1.6	2.0	-2.7
Leg predicted mass (right)	0.3	1.7	3.5	1.9	-0.3	-1.1	-0.6	1.4	-1.8
Arm fat mass (left)	0.1	0.3	1.4	-0.2	1.2	-0.2	-0.8	0.2	0.1
Number of self-reported non-cancer illnesses	0.4	0.8	2.4	-0.3	-1.5	0.6	1.1	0.1	0.7
Average weekly champagne plus white wine intake	0.4	0.5	2.4	0.4	-0.2	0.0	1.6	-0.5	0.2
Miserableness	1.7	2.9	5.3	2.3	-0.2	2.1	0.3	2.1	1.8
Guilty feelings	1.1	1.6	5.0	2.2	-0.9	0.9	0.9	1.4	-0.6
Wears glasses or contact lenses	2.0	2.3	6.1	-2.5	-0.7	-0.8	1.0	-2.2	-0.6
Ever taken oral contraceptive pill	0.3	0.4	1.1	-0.8	-0.2	-0.0	-0.5	-0.2	-1.1
Hearing aid user	0.3	0.3	0.9	-0.7	0.0	0.4	0.6	0.3	1.0
Mother’s age at death	0.1	0.1	0.3	-0.5	0.4	0.2	0.4	-0.3	0.3
Financial situation satisfaction	0.4	0.5	0.9	0.7	0.7	0.9	-0.1	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.4	0.1	0.1	-0.7	-0.2	1.2	-0.4
Commuting to job workplace: Public transport	0.5	0.6	2.1	-0.7	-0.7	-1.4	-0.1	-0.4	0.4
Eye problems/disorders: Glaucoma	0.5	0.6	2.1	0.0	-0.4	0.2	1.4	-0.2	-1.0
Medication: Blood pressure	0.5	1.0	3.8	-0.6	-1.2	0.1	0.2	0.2	1.9
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.6	0.1	0.2	-1.3	-1.0	1.0	0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	5.3	-0.8	-1.2	0.2	-0.6	0.4	-2.3
High cholesterol (Self-reported)	0.3	0.5	1.5	-0.8	-1.2	0.1	-0.7	-0.1	-0.1
Medication: Bendroflumethiazide	0.7	1.1	4.4	-0.6	-0.9	-0.6	2.1	0.2	0.8
Medication: Paracetamol	1.6	2.4	7.8	0.4	-1.4	-2.8	-0.6	0.8	2.0
Medication: Lisinopril	0.3	0.4	1.9	-0.4	-0.3	0.4	1.4	-0.4	-0.3
Medication: Atorvastatin	1.4	1.7	3.3	0.4	-1.4	0.3	-1.8	1.5	1.6
Illnesses of father: High blood pressure	0.4	0.5	1.6	0.4	-0.3	1.3	0.6	-0.5	0.8
Alcohol drinker status: Never	0.3	0.3	0.8	-0.7	-0.9	0.0	-0.7	0.1	-0.4
Ever smoked	0.2	0.3	1.0	-0.1	0.8	-0.2	-0.1	-0.5	-1.0
Basal metabolic rate	0.6	3.2	7.6	2.8	0.8	-0.3	-1.6	1.8	-2.2
Leg fat percentage (left)	0.4	1.3	4.6	0.1	2.1	0.7	-1.6	-0.4	-0.2
Arm fat-free mass (left)	1.1	5.5	14.1	3.8	1.3	-0.5	-2.3	2.6	-2.3
Number of operations (self-reported)	0.2	0.3	0.7	-0.8	-0.5	-0.8	0.1	0.1	0.4
Average weekly beer plus cider intake	0.7	1.0	3.0	-1.7	0.7	-1.4	-0.6	0.0	-0.5
Irritability	0.3	0.5	1.1	0.6	0.7	1.1	0.8	0.7	-0.2
Risk taking	0.5	0.7	2.0	-1.0	0.4	-1.4	0.5	-0.8	-0.6
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.1	-0.6	-1.5	-0.0	0.9	-0.9	0.1
Fractured/broken bones in last 5 years	0.6	0.7	2.4	-0.4	-0.4	-0.6	1.1	-0.3	1.5
Age started oral contraceptive pill	1.2	1.4	3.6	-0.8	1.0	-1.9	-1.7	-0.5	-0.5
Diastolic blood pressure, automated reading	0.7	2.1	7.2	0.0	-2.7	0.4	-1.2	-0.7	1.7
Ever depressed for a whole week	2.9	3.5	9.7	3.1	0.8	-0.4	-2.5	2.1	-0.4
Unable to work because of sickness or disability	0.3	0.4	1.6	0.0	-0.0	0.1	-0.5	0.6	-1.3
Commuting to job workplace: Cycle	0.8	1.0	3.6	-1.0	1.0	0.0	-1.9	-0.5	-0.1
Myopia	0.3	0.4	1.4	1.2	-0.6	0.6	0.1	0.5	0.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.8	0.7	2.0	-0.1	-0.5	-0.1	-0.7
Cholesterol lowering medication	0.3	0.4	1.4	-0.7	0.2	0.5	-1.2	0.1	0.6
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	6.3	0.2	0.2	1.7	1.9	0.5	-2.5
Pain experienced in last month	0.1	0.2	0.9	0.4	-0.1	-0.2	-0.3	-0.9	-0.4
Supplements: Calcium	0.6	0.7	1.6	0.5	-1.3	0.7	-0.5	1.2	0.3
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	0.1	0.8	-1.2	-1.1	-0.2	-1.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	0.4	-0.1	-0.6	-0.4	1.2	0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	3.3	0.2	-1.8	0.5	0.8	-0.2	0.4
Heart disease (siblings)	0.1	0.1	0.2	-0.3	0.4	-0.2	-0.4	-0.1	-0.3
Alcohol drinker status: Previous	0.6	0.6	1.4	0.6	-0.4	-1.1	-0.9	1.2	-0.1
Pack years of smoking	1.0	1.4	3.5	-1.9	-0.5	-1.6	-1.4	0.1	-0.2
Impedance of whole body	1.0	4.9	12.6	-1.9	0.4	3.5	1.7	-2.2	2.4
Leg fat mass (left)	0.2	0.7	2.0	0.3	1.3	0.3	-1.4	0.0	-0.5
Arm predicted mass (left)	1.0	5.2	12.0	3.5	1.4	-0.6	-2.5	2.5	-2.1