TWAS hub - SHISA5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0590	0.0270	5.6e-06	0.076	0.054	0.067	0.055	0.074	1.6e-09	3.2e-07	1.4e-08	2.9e-07	2.7e-09
2	GTEx	Nerve Tibial	0.0811	0.0416	3.2e-03	-0.004	NA	0.001	NA	-0.004	9.6e-01	NA	2.4e-01	NA	7.9e-01
3	GTEx	Spleen	0.1290	0.0630	6.9e-03	-0.011	NA	-0.006	NA	-0.012	7.8e-01	NA	5.0e-01	NA	9.9e-01
4	METSIM	Adipose	0.0453	0.0203	9.8e-07	0.036	0.036	0.033	0.033	0.029	3.1e-06	3.2e-06	9.5e-06	7.8e-06	2.8e-05
5	ROSMAP	Brain Pre-frontal Cortex	0.1116	0.0380	1.8e-10	0.081	0.100	0.099	0.100	0.092	1.5e-10	8.9e-13	9.7e-13	8.1e-13	6.6e-12
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.3247	0.1126	2.2e-04	0.034	0.038	0.037	NA	0.029	8.3e-05	3.6e-05	4.3e-05	NA	2.8e-04
7	TCGA	Prostate Adenocarcinoma	0.0433	0.0226	1.4e-05	0.043	0.046	0.040	NA	0.048	2.7e-05	1.4e-05	4.5e-05	NA	7.9e-06
8	TCGA	Thyroid Carcinoma	0.0520	0.0350	4.8e-04	0.035	0.032	0.059	NA	0.041	2.4e-04	4.4e-04	2.0e-06	NA	6.8e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6	7	8
Ulcerative Colitis (UC)	5.7	10.6	25.4	-2.6	-0.3	-4.2	-5.0	-4.9	-3.4	-0.1
Number of incorrect matches in round	5.0	8.2	18.6	3.3	0.6	3.2	4.3	1.5	3.9	3.0
Osteoporosis (self-reported)	4.8	5.9	11.2	3.3	1.7	3.1	2.8	-0.4	3.2	2.3
Migraine (self-reported)	4.5	5.6	11.8	-2.8	-0.6	-3.3	-3.4	-0.9	-2.8	-2.2
Father’s age at death	4.0	5.3	12.3	-2.2	-0.4	-2.6	-3.5	-3.4	-2.5	-0.7
Family relationship satisfaction	3.8	4.7	10.2	2.8	2.4	2.5	2.4	1.1	3.2	0.8
Irritable Bowel Disease (IBD)	3.7	8.8	32.1	-1.3	-0.2	-4.0	-4.1	-5.7	-2.1	0.2
Friendships satisfaction	3.6	4.4	11.2	2.7	3.3	2.3	1.5	-0.3	2.9	0.5
Ulcerative Colitis	3.4	5.0	12.5	-1.6	-0.6	-3.2	-3.5	-2.9	-2.3	0.3
Mouth/teeth dental problems: Loose teeth	3.1	3.7	7.3	-2.7	-1.8	-2.2	-1.6	1.3	-2.1	-2.3
Miserableness	2.9	5.1	9.8	2.9	1.6	2.0	3.1	1.5	3.1	2.0
Mean Putamen Volume	2.8	3.3	7.1	-2.0	-1.6	-2.5	-2.7	-0.3	-2.3	-0.7
Waist Hip Ratio (WHR)	2.8	12.4	25.5	-4.3	-1.7	-2.7	-5.0	-0.4	-4.7	-4.8
Tense / ‘highly strung’	2.5	4.1	9.4	2.3	1.3	3.1	2.5	0.9	3.0	0.7
Birth weight of first child	2.5	4.6	7.6	-2.8	-1.8	-2.7	-2.6	-0.9	-2.6	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.8	7.2	-1.3	-2.0	-2.7	-1.9	-1.1	-2.1	0.2
Pack years adult smoking proportion	2.2	3.4	7.0	2.2	0.6	2.3	2.6	1.6	2.3	1.2
Myopia	2.2	3.1	12.3	1.7	3.5	1.6	1.1	-2.1	1.2	0.5
Fed-up feelings	2.1	3.9	9.7	2.5	1.7	1.9	3.1	1.0	2.4	1.3
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	6.1	2.0	2.5	2.2	2.1	0.7	2.3	1.3
Fasting Glucose	2.0	2.4	7.3	1.7	1.8	2.7	1.8	0.5	1.4	-0.0
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	7.0	-1.6	-1.9	-2.6	-1.9	-1.9	-1.8	-1.6
Major Depression (MDD)	1.9	2.3	4.6	2.1	1.3	1.3	1.6	0.9	1.9	1.8
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	4.3	1.6	1.0	1.2	1.9	2.1	1.5	0.9
Falls in the last year	1.9	2.6	6.0	-2.0	-1.4	-2.5	-1.3	-0.2	-2.0	-1.8
Number of full sisters	1.9	2.3	6.9	-1.2	-2.6	-2.6	-0.6	1.1	-1.1	-0.9
Qualifications: nursing, teaching	1.9	3.0	7.0	2.6	1.2	1.8	1.0	0.7	2.6	2.0
Illnesses of father: High blood pressure	1.9	2.3	6.9	-1.2	0.2	-0.6	-2.6	-1.9	-2.0	-1.3
Depressed Affect (Nagel 2018)	1.8	3.7	7.0	2.6	1.9	1.7	2.5	0.9	2.6	1.6
Hypothyroidism (self reported)	1.8	4.1	8.5	2.9	1.1	2.0	2.6	0.3	2.9	1.9
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	7.7	-0.6	2.8	0.5	-2.5	-2.7	-0.6	-0.4
Had major operations	1.8	2.1	4.0	1.8	0.2	1.6	2.0	1.9	1.5	1.2
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.8	1.4	-1.3	1.3	2.2	1.7	1.6	0.6
Length of working week for main job	1.7	1.9	10.3	0.1	-3.2	-1.1	0.5	1.8	-0.1	-0.1
Medication: Paracetamol	1.7	2.7	8.8	1.9	0.5	1.7	3.0	0.2	2.3	0.6
Crohns Disease (2012)	1.6	2.5	11.6	0.8	0.9	-1.6	-0.9	-3.4	0.5	1.9
Blood White Count	1.6	11.6	28.2	2.7	2.3	5.0	3.7	5.3	3.6	-0.9
Irritability	1.6	2.7	6.7	2.3	-0.4	1.3	1.9	1.9	2.6	0.7
HbA1C	1.5	1.7	4.6	-1.6	-0.3	-0.2	-1.8	-0.8	-1.5	-2.1
Lung FEV1/FVC ratio	1.5	7.7	20.2	-3.3	-0.7	-3.2	-4.5	-0.0	-3.8	-2.1
Forced expiratory volume in 1-second (FEV1)	1.5	5.1	17.6	-2.4	-0.2	-1.8	-4.2	-0.9	-2.8	-2.4
Knee pain experienced in last month	1.5	2.4	6.2	-2.2	-0.9	-2.5	-0.9	-0.8	-2.0	-1.2
Crohns Disease (2017)	1.4	3.0	16.6	0.4	-0.1	-2.2	-1.5	-4.1	-0.1	0.3
Primary Biliary Cirrhosis	1.4	2.0	5.5	-1.3	-2.4	-2.3	-1.0	0.1	-1.5	0.6
Triglycerides	1.4	2.3	6.1	-1.8	-1.3	-1.2	-2.5	0.5	-2.2	-0.8
Neuroticism	1.4	3.4	8.0	2.1	-0.4	2.2	2.8	2.0	2.3	0.8
Exposure to tobacco smoke at home	1.4	1.5	5.9	1.1	1.1	1.6	0.9	2.4	0.8	0.4
Frequency of depressed mood in last 2 weeks	1.3	1.8	4.3	1.4	2.1	1.4	1.6	0.6	1.7	0.4
Pain all over the body in last month	1.3	1.4	4.2	0.9	0.5	1.4	1.5	2.0	0.9	0.9
Worrier / anxious feelings	1.3	2.4	5.9	1.6	1.3	2.4	1.5	1.0	1.8	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	14.7	-2.2	-0.3	-1.9	-3.8	-0.5	-2.6	-1.8
Peak expiratory flow (PEF)	1.3	3.0	7.9	-1.7	0.2	-1.8	-2.8	-1.3	-2.0	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.8	-1.4	-0.7	-1.2	-1.1	-0.8	-1.7	-2.0
Neuroticism (Nagel 2018)	1.2	2.7	6.3	2.2	0.6	1.7	2.2	1.2	2.5	1.1
Prostate Cancer	1.2	1.6	3.5	1.1	0.2	1.6	1.9	1.1	1.2	1.7
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.5	1.6	0.7	1.9	1.3	0.7	1.6	0.0
Hand grip strength (left)	1.2	3.0	19.5	0.8	4.4	1.7	0.1	-0.8	0.7	0.5
Diabetes (father)	1.2	1.5	3.0	-1.6	-1.1	-1.2	-1.6	-0.6	-1.7	-0.4
Age when periods started (menarche)	1.2	2.8	5.8	1.8	1.7	2.4	2.2	0.9	2.0	-1.1
Qualifications: None of the above	1.2	2.5	7.2	0.0	-2.6	-1.1	2.1	2.7	-0.1	0.7
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.7	1.5	1.1	0.6	1.3	1.1	1.4	1.6
Commuting to job workplace: Car/motor vehicle	1.2	1.4	3.7	-1.3	-1.7	-1.9	-0.7	0.2	-1.1	-1.2
Smoking status: Previous	1.2	1.8	5.7	-1.0	-2.4	-2.3	-0.3	-0.4	-1.0	-1.2
Commuting to job workplace: Walk	1.2	1.2	2.1	1.4	0.5	1.4	0.9	1.4	1.3	1.0
Pack years of smoking	1.2	1.8	3.9	1.6	0.2	1.7	2.0	1.4	1.6	0.7
Neuroticism (2016)	1.1	1.6	3.2	1.7	0.6	1.8	1.3	1.0	1.6	1.0
BMI	1.1	6.5	15.8	2.7	2.2	1.3	4.0	3.7	2.6	1.2
Diabetes (self-reported)	1.1	1.7	3.1	-1.2	-1.3	-1.2	-1.6	1.0	-1.8	-1.5
Pulse rate	1.1	1.8	5.1	-1.4	-0.1	-0.3	-2.3	1.5	-1.7	-1.4
Number of full brothers	1.1	1.4	5.1	0.3	-2.3	-0.5	1.1	1.9	0.6	0.6
Age at first live birth	1.1	1.9	6.6	-0.4	2.6	0.8	-1.8	-2.1	-0.6	-0.3
Medication: Aspirin	1.1	1.4	5.3	-1.0	-1.9	-0.4	-0.4	2.3	-0.9	-0.6
Intelligence (Savage-Jansen 2018)	1.0	2.9	11.0	-0.4	-0.6	-1.6	-2.9	-3.3	-0.8	-0.9
Sensitivity / hurt feelings	1.0	1.6	5.2	-1.1	-1.7	-1.1	-1.2	-0.1	-1.0	-2.3
Medication: Metformin	1.0	1.4	4.5	-0.9	-1.5	-0.1	-0.7	1.6	-0.8	-2.1
Taking other prescription medications	1.0	1.6	4.3	1.1	1.9	2.1	1.4	0.7	1.2	-0.2
Medication: Atenolol	1.0	1.3	8.2	-0.7	-0.7	0.8	0.5	2.9	-0.4	-0.2
Loneliness, isolation	1.0	1.4	2.7	1.5	1.2	1.1	1.2	0.2	1.4	1.6
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.4	-1.4	0.2	-1.3	-1.8	-0.3	-1.6	-0.3
Ever depressed for a whole week	1.0	1.2	4.3	0.8	-0.6	-0.3	2.1	0.5	1.3	1.6
Body Mass Index (BMI) (2010)	0.9	1.3	3.5	1.5	0.8	0.1	0.9	0.5	1.5	1.9
Number of treatments/medications taken	0.9	1.6	4.4	0.7	0.6	2.1	1.4	2.1	0.9	-0.4
Hand grip strength (right)	0.9	2.4	15.7	0.6	4.0	1.7	-0.2	-0.2	0.4	-0.3
Relative age voice broke	0.9	1.4	3.5	1.2	1.0	0.7	1.1	0.5	1.8	1.9
Hayfever, allergic rhinitis or eczema	0.9	1.9	4.5	1.3	2.1	1.8	0.5	-0.9	1.3	1.7
Neuroticism score	0.9	1.8	3.5	1.5	-0.4	1.3	1.9	1.8	1.8	0.5
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.6	-1.6	0.2	-0.8	-1.1	-0.7	-1.6	-1.0
Qualifications: College or University degree	0.9	2.8	6.8	1.1	2.3	0.4	-2.5	-2.6	0.7	1.5
Medication for pain relief, constipation, heartburn	0.9	1.5	4.1	-0.1	2.0	0.4	-1.4	-2.0	-0.1	1.3
Pulse rate, automated reading	0.9	2.8	5.8	-1.3	1.0	1.8	-2.3	1.9	-1.5	-2.4
Leg pain on walking	0.9	1.1	3.3	-1.3	0.4	-0.6	-1.1	-0.9	-1.2	-1.8
Mood swings	0.9	1.5	4.6	1.6	2.1	1.0	1.0	0.0	1.4	1.0
Long-standing illness, disability or infirmity	0.9	1.4	3.0	-1.0	-0.2	-1.4	-1.5	-1.1	-1.4	-1.7
Medication: Aspirin	0.9	1.2	3.8	-0.9	-1.8	-0.5	-0.5	1.9	-0.9	-0.4
Ever taken oral contraceptive pill	0.9	1.1	2.6	0.9	-0.5	1.5	1.6	0.7	1.4	-0.3
Financial situation satisfaction	0.9	1.2	2.6	1.5	0.7	1.2	0.9	1.3	1.6	0.3
Heart attack/myocardial infarction (self-reported)	0.9	1.2	7.1	0.7	-0.3	0.6	0.6	2.7	0.4	0.9
Bipolar Disorder (2018)	0.8	1.3	4.6	0.7	2.0	-0.1	-0.1	0.1	0.9	2.1
Depression (Nagel 2018)	0.8	1.1	5.5	1.1	2.4	0.8	0.6	-0.3	1.1	0.5
Alzheimer’s Disease (in father)	0.8	0.9	2.1	-1.3	0.4	-0.7	-1.4	-0.4	-1.2	-1.1
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.4	-1.3	-0.7	-0.6	-0.8	-1.1	-1.5	-0.8
Qualifications: CSEs or equivalent	0.8	1.1	6.0	0.7	2.4	0.9	0.7	-0.9	0.6	-0.1
Serious illness, injury or assault to yourself	0.8	1.0	4.0	0.3	2.0	0.6	0.3	-1.4	-0.1	-1.2
Body mass index (BMI)	0.8	3.3	13.7	1.5	0.7	0.5	2.8	3.7	1.4	0.6
Past tobacco smoking	0.8	1.5	5.2	0.6	2.2	2.3	-0.4	0.3	0.4	1.0
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.7	1.1	1.1	-0.1	1.2	-0.7	1.3	1.2
Heart attack	0.8	1.0	6.0	0.7	-0.3	0.5	0.6	2.5	0.4	0.9
Arm fat percentage (right)	0.8	3.1	11.9	1.5	0.8	1.0	2.5	3.4	1.4	1.0
Lung cancer (father)	0.8	1.0	3.2	1.4	0.3	0.5	1.1	0.2	1.2	1.8
Arm fat mass (right)	0.8	3.3	13.6	1.5	1.4	1.3	2.3	3.7	1.4	0.1
Blood clot in the leg (DVT)	0.8	1.0	2.9	-0.9	-0.4	-1.5	-1.0	-1.7	-1.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.9	1.4	1.3	0.8	0.8	-0.7	1.2	1.0
Health satisfaction	0.8	1.0	2.7	1.2	1.6	1.4	0.9	-0.1	1.0	-0.2
Emphysema/chronic bronchitis	0.8	0.9	2.4	-0.7	-1.6	-1.5	-0.4	-0.9	-0.6	-0.8
Medication: Omeprazole	0.8	1.0	2.0	-1.1	-1.4	-1.0	-0.1	1.4	-1.0	-0.7
Whole body fat mass	0.8	3.4	13.5	1.6	1.8	1.6	1.9	3.7	1.3	-0.2
Leg fat mass (right)	0.8	3.1	13.8	1.3	1.4	1.2	2.1	3.7	1.1	-0.3
Arm fat percentage (left)	0.8	3.2	13.3	1.5	1.0	1.2	2.3	3.7	1.2	0.9
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.2	0.8	1.8	1.0	0.2	-1.3	0.9	0.2
Arm fat mass (left)	0.8	3.3	13.0	1.6	1.5	1.3	2.2	3.6	1.4	0.1
Hearing aid user	0.8	0.9	2.2	-0.7	1.0	-0.8	-1.5	-1.2	-1.0	-0.7
Commuting to job workplace: Public transport	0.8	1.0	4.5	0.4	1.7	2.1	0.1	-0.4	0.1	0.2
Alcohol drinker status: Never	0.8	0.9	1.7	-1.2	-1.1	-1.3	-1.2	-0.4	-0.8	0.8
Number of operations (self-reported)	0.8	1.2	4.8	1.2	-0.3	0.8	2.2	1.1	1.1	0.0
Unable to work because of sickness or disability	0.8	1.0	2.1	-1.3	-1.2	-1.4	0.0	-0.9	-1.2	-0.6
Alcohol drinker status: Previous	0.8	0.9	3.3	-1.2	-1.8	-0.5	0.5	0.4	-1.0	-0.8
Leg fat mass (left)	0.8	3.0	13.1	1.4	1.4	1.1	2.1	3.6	1.1	-0.3
Blood Platelet Count	0.7	8.1	16.2	-3.1	-2.4	-3.6	-4.0	-1.9	-3.1	-2.7
Lung FVC	0.7	3.4	7.8	-2.3	-2.2	-2.2	-2.8	0.5	-2.0	-0.5
Chronotype (morning person)	0.7	1.7	3.9	1.8	2.0	1.4	0.3	1.0	1.1	1.4
Supplements: Zinc	0.7	0.7	3.0	0.3	-1.7	-0.3	0.6	-0.4	0.4	1.3
Leg fat-free mass (left)	0.7	3.5	9.4	2.0	3.1	2.0	1.3	2.3	1.7	-0.8
Trunk fat percentage	0.7	2.7	11.0	1.4	1.3	1.6	1.6	3.3	1.1	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	5.6	-0.1	2.4	0.6	-1.9	-1.1	-1.0	0.7
Sitting height	0.7	4.7	11.1	2.3	3.1	3.3	-0.2	2.2	1.8	-1.9
Trunk fat mass	0.7	2.9	10.0	1.5	2.0	1.7	1.5	3.2	1.1	-0.1
Mouth/teeth dental problems	0.7	1.1	3.4	1.0	1.0	1.8	0.8	0.1	1.1	1.4
Hip circumference	0.7	2.8	9.9	1.8	1.4	1.0	2.0	3.1	1.6	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.7	0.4	0.9	0.7	0.5	-1.9	0.8	0.8
Loud music exposure frequency	0.7	0.8	2.1	-0.5	-0.9	-1.3	-1.5	1.0	-0.7	-0.0
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.3	-0.7	-0.8	-1.4	-1.5	-1.3	-0.6	-0.2
Body fat percentage	0.7	3.0	13.0	1.4	1.1	1.4	2.1	3.6	1.1	0.5
Comparative body size at age 10	0.7	1.9	7.9	-1.4	-1.9	-2.8	-0.5	-0.0	-1.4	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.7	-0.6	1.6	-0.2	-0.6	-0.7	-0.7	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.3	1.2	-0.7	0.3	1.8	0.5	1.0	-0.2
Back pain experienced in last month	0.7	1.1	2.0	-1.3	-0.7	-1.4	-0.6	-0.9	-1.2	-1.4
Wears glasses or contact lenses	0.7	0.8	1.8	1.0	1.3	1.2	0.5	-0.1	0.9	0.8
Arm fat-free mass (left)	0.7	3.7	7.6	2.2	2.8	1.8	1.9	2.2	2.1	-1.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.1	-1.1	-0.0	-1.0	-1.2	-1.4	-1.0	0.0
Heart disease (siblings)	0.7	0.9	3.6	0.7	-0.7	0.3	1.3	1.9	0.9	0.2
Breast Cancer	0.6	1.5	5.2	-1.3	0.1	-1.2	-2.3	-0.9	-1.5	-0.6
Blood Eosinophil Count	0.6	4.8	12.5	-2.0	1.6	-0.3	-3.5	1.0	-2.7	-3.3
Heel T-Score	0.6	4.5	24.2	0.8	4.9	3.1	-1.0	-0.5	0.1	-0.1
Height	0.6	11.1	32.0	-0.9	5.7	1.5	-5.5	-1.9	-1.5	-4.2
Vitamin and mineral supplements	0.6	0.8	2.2	-0.3	1.5	1.2	-0.3	-0.3	-0.5	-1.4
Medication: Co-codamol	0.6	0.7	3.0	0.2	-0.3	0.5	1.7	1.3	0.6	0.3
Diabetes (mother)	0.6	0.8	3.4	0.4	-0.5	1.3	0.6	1.9	0.3	-0.6
Stomach or abdominal pain in last month	0.6	0.7	1.9	0.4	-1.4	0.5	1.0	1.4	0.8	0.1
Leg predicted mass (left)	0.6	3.3	9.1	1.9	3.0	1.9	1.2	2.2	1.6	-0.9
Hair/balding pattern: Pattern 2	0.6	0.8	1.4	-1.1	-0.7	-1.2	-1.1	-0.5	-0.9	-1.0
Weight	0.6	3.0	8.4	1.6	2.5	1.5	1.3	2.9	1.2	-0.7
Medication: Lansoprazole	0.6	0.6	2.0	0.5	0.6	1.4	-0.0	1.4	0.5	-0.6
Illnesses of mother	0.6	0.7	2.3	1.4	0.1	0.2	1.5	-0.2	1.0	0.7
Medication: Paracetamol	0.6	1.0	4.1	1.1	-0.3	0.7	2.0	0.3	1.4	-0.1
Forced vital capacity (FVC), Best measure	0.6	2.3	8.9	-1.5	0.4	-0.7	-3.0	-0.7	-1.7	-1.7
Leg fat percentage (right)	0.6	2.4	12.5	0.7	0.3	0.7	2.1	3.5	0.7	-0.0
Arm fat-free mass (right)	0.6	3.0	8.1	1.8	2.9	1.5	1.1	2.1	1.5	-1.6
Angina (self-reported)	0.6	0.7	5.3	0.2	-0.4	0.1	0.5	2.3	0.3	-0.2
Arm predicted mass (right)	0.6	3.3	8.1	1.9	2.8	1.8	1.4	2.2	1.6	-1.6
Average weekly beer plus cider intake	0.6	0.9	2.0	0.9	0.7	1.4	1.4	0.4	1.4	-0.2
Risk taking	0.6	0.9	1.9	-0.8	-1.2	-1.4	-0.4	1.3	-0.7	-1.0
Diastolic blood pressure, automated reading	0.6	1.9	7.8	0.4	1.1	2.8	1.1	1.9	0.9	-0.6
Commuting to job workplace: Cycle	0.6	0.7	1.5	1.1	0.7	1.2	0.2	-1.2	0.7	0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	3.5	-0.5	-0.0	-1.2	-0.8	-1.9	-0.8	0.1
Impedance of whole body	0.6	2.9	10.8	-1.8	0.0	-0.0	-3.3	-2.1	-2.0	-0.5
Bipolar Disorder or Schizophrenia	0.5	1.3	4.3	1.3	1.1	0.3	0.4	0.9	1.5	2.1
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	-1.2	0.8	0.1	-1.2	-0.9	-0.9	-0.7
Reaction Time	0.5	1.0	1.8	1.3	-0.3	1.2	1.0	-0.7	1.3	1.1
Bipolar Disorder (2011)	0.5	0.5	1.3	-0.5	-0.7	-1.1	-0.8	-0.5	0.0	0.9
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.6	-0.9	-0.7	-0.5	0.0	0.8	-0.5	-1.6
Ever had hysterectomy (womb removed)	0.5	0.5	2.7	0.2	-0.5	0.6	1.6	-0.6	0.2	-0.6
Angina	0.5	0.6	4.4	0.2	-0.0	0.2	0.5	2.1	0.3	-0.2
Townsend deprivation index at recruitment	0.5	0.8	1.7	0.9	-1.3	0.1	1.0	1.2	0.7	0.8
Multivitamins +/- minerals	0.5	0.6	1.7	-0.3	-1.1	-1.3	-0.5	0.1	-0.1	1.2
Chronic bronchitis/emphysema (father)	0.5	0.6	2.5	-0.2	-1.0	0.6	1.6	-0.4	0.3	-1.0
Impedance of leg (left)	0.5	2.4	7.2	-1.8	-0.6	-0.4	-2.7	-1.7	-1.9	-1.1
Forced vital capacity (FVC)	0.5	1.8	7.2	-1.2	0.2	-0.4	-2.7	-0.6	-1.4	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.4	0.0	2.1	1.0	-1.6	-0.7	-0.9	0.1
Medication: Ramipril	0.5	0.6	2.7	0.4	-0.7	-0.3	0.2	1.6	0.5	1.1
Impedance of arm (right)	0.5	2.4	7.8	-1.3	0.5	0.4	-2.7	-2.8	-1.4	0.1
Happiness	0.5	0.6	3.1	0.3	1.8	0.5	-0.2	0.3	0.9	-0.4
Mouth/teeth dental problems: Dentures	0.5	0.8	4.4	-0.4	0.1	-0.3	0.8	2.1	-0.4	-1.0
Impedance of arm (left)	0.5	2.4	9.4	-1.3	0.6	0.4	-3.1	-2.3	-1.6	-0.1
Standing height	0.5	5.2	15.6	0.3	4.0	2.2	-3.0	-1.1	-0.2	-3.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.6	0.8	1.6	0.5	0.6	0.0	0.9	0.8
Medication: Blood pressure	0.5	0.9	3.7	0.2	0.6	1.9	0.4	1.6	0.0	-0.6
Alcohol intake frequency.	0.5	1.1	2.9	-1.3	0.1	-0.9	-1.7	0.9	-1.7	-0.2
Age at last live birth	0.5	0.8	3.0	0.4	1.7	0.7	-1.1	-1.0	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	4.7	-0.0	2.2	0.7	-1.2	-0.5	0.1	-1.2
Whole body fat-free mass	0.5	2.7	9.2	1.7	3.0	1.6	0.9	1.4	1.4	-1.4
Leg fat-free mass (right)	0.5	2.7	8.8	1.8	3.0	1.6	0.9	1.7	1.4	-1.0
Ever had bowel cancer screening	0.5	0.6	2.2	-0.3	-1.1	-1.1	0.1	-1.5	-0.3	-0.2
Diabetes diagnosed by doctor	0.5	0.8	2.1	-0.6	-0.3	-0.6	-1.4	0.7	-1.2	-1.4
Breast cancer (self-reported)	0.5	0.6	2.5	-0.6	0.4	0.3	-0.6	0.4	-0.9	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.9	-1.1	-0.2	-1.5	-2.0	-0.1	-1.3	0.3
Whole body water mass	0.5	2.8	8.7	1.8	2.9	1.6	1.1	1.6	1.5	-1.4
Leg predicted mass (right)	0.5	2.8	8.6	1.9	2.9	1.6	1.0	1.8	1.5	-1.0
High cholesterol (Self-reported)	0.5	0.9	2.4	-1.0	-0.0	-0.9	-1.4	-0.5	-1.6	-0.6
Ever smoked	0.5	0.8	3.0	0.1	-1.7	-1.4	1.1	-0.4	0.3	-0.3
Basal metabolic rate	0.5	2.9	9.2	1.8	3.0	1.6	1.1	1.8	1.4	-1.2
Leg fat percentage (left)	0.5	2.0	10.6	0.7	0.4	0.5	1.9	3.3	0.5	-0.3
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.8	-1.1	-0.6	-1.5	-1.0	-2.2	-0.9	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.0	-0.8	-0.8	-1.0	0.2	1.4	-0.6	-0.7
Arm predicted mass (left)	0.5	2.5	5.9	1.5	2.4	1.2	1.2	2.1	1.3	-1.7
Age at First Birth	0.4	0.6	1.6	-0.8	-0.4	0.5	-1.2	-0.6	-0.7	-1.0
Coronary Artery Disease (CAD)	0.4	0.5	2.2	0.3	1.5	1.3	0.5	-0.1	-0.0	0.1
HDL Cholesterol	0.4	0.7	2.7	-0.9	-0.8	-1.0	-0.4	-1.6	-0.5	-0.7
LDL Cholesterol	0.4	0.7	2.1	-0.9	-0.1	-0.2	-1.3	0.2	-1.5	-0.8
Lupus	0.4	0.7	2.2	-0.5	-0.2	-1.0	-1.5	-0.0	-1.1	-0.8
Schizophrenia (2014)	0.4	0.8	2.2	1.1	0.2	0.5	0.9	0.9	1.5	1.1
Smoking Status	0.4	1.0	3.6	0.2	-1.9	-1.4	1.5	0.3	0.3	0.2
Average weekly spirits intake	0.4	0.5	1.9	0.1	-0.8	0.6	1.4	1.2	0.1	-0.1
Medication for hormone replacement therapy	0.4	0.4	1.3	0.6	0.4	1.0	0.6	1.1	0.5	0.4
Severe depression (siblings)	0.4	0.4	2.8	-0.0	-0.8	0.1	-0.3	0.1	-0.1	1.7
High blood pressure (mother)	0.4	0.6	1.8	-1.0	-0.2	-1.0	-1.4	0.5	-0.6	-0.5
Alcohol usually taken with meals	0.4	0.7	2.2	-0.8	1.1	0.3	-1.5	-1.0	-0.8	0.0
Hearing difficulty/problems with background noise	0.4	0.7	1.6	1.2	0.4	0.2	1.0	-0.9	1.2	0.5
Had menopause	0.4	0.5	2.0	-0.6	-1.2	-1.4	-0.2	-0.1	-0.2	-0.5
Allergy	0.4	1.0	4.2	-0.6	-1.5	-0.2	0.4	2.0	-0.1	-1.0
Medication: Simvastatin	0.4	0.5	1.2	-0.8	-0.4	-0.3	-0.7	0.7	-1.1	-1.1
Trunk fat-free mass	0.4	2.1	8.2	1.2	2.9	1.3	0.5	0.6	1.1	-1.8
Time employed in main current job	0.4	0.4	0.9	-0.3	0.5	-0.5	-0.9	-1.0	-0.9	-0.3
Alcohol intake versus 10 years previously	0.4	0.7	2.1	-0.6	0.6	-0.1	-1.1	1.4	-1.2	0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.8	-0.1	0.3	-0.4	-1.9	-1.4	0.4	1.0
Prospective memory result	0.4	0.5	2.6	0.3	-0.3	0.2	0.2	1.0	0.2	1.6
Trunk predicted mass	0.4	2.1	8.4	1.2	2.9	1.3	0.5	0.7	1.1	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	3.1	0.6	0.1	0.2	1.8	0.8	0.9	0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.4	0.2	-0.6	-1.3	0.3	-1.5	0.5	1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.6	1.2	0.1	0.8	1.1	-0.7	1.3	0.8
Mean time to correctly identify matches	0.4	0.7	1.5	0.9	-1.2	0.9	1.0	-0.4	0.9	0.6
Chest pain or discomfort	0.4	0.6	1.8	0.7	-0.2	1.1	1.4	0.8	1.0	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	-0.3	-0.3	-0.8	-0.4	-1.0	-0.5	0.9
Osteoarthritis (self-reported)	0.4	0.6	2.6	-0.8	0.3	-0.1	0.1	1.6	-0.3	-1.1
Average weekly champagne plus white wine intake	0.4	0.5	1.1	0.9	-0.0	0.5	0.7	-0.7	1.1	0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.5	0.4	0.9	0.3	0.6	0.7	0.6	-1.2
Schizophrenia (2018)	0.3	0.6	1.5	1.1	-0.1	0.5	0.6	1.0	1.2	0.7
Worry (Nagel 2018)	0.3	0.7	2.5	0.4	0.9	1.6	0.9	0.1	1.0	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	4.0	0.1	-1.1	0.1	-0.8	-2.0	-0.0	-0.7
Ovarian Cancer	0.3	0.4	1.4	0.3	-0.3	1.0	1.2	-0.6	0.6	-0.2
Rheumatoid Arthritis	0.3	0.4	0.8	-0.4	-0.6	-0.8	-0.7	-0.9	-0.7	-0.3
Systolic blood pressure, automated reading	0.3	0.9	3.3	0.4	0.3	1.4	1.0	1.8	0.8	-0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.1	0.4	0.2	0.7	0.5	1.0	0.5	-0.5
Impedance of leg (right)	0.3	1.5	5.2	-1.6	-0.5	0.0	-2.3	-1.2	-1.6	-0.6
Average weekly fortified wine intake	0.3	0.4	0.8	0.6	0.8	0.7	0.9	-0.8	0.5	-0.2
Maternal smoking around birth	0.3	0.4	0.8	-0.6	-0.2	-0.6	-0.7	-0.8	-0.6	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	3.2	0.0	1.8	0.3	-0.2	0.2	0.1	0.3
Medication: Levothyroxine sodium	0.3	0.5	1.1	0.9	-0.4	0.6	1.0	0.0	1.1	0.7
Waist circumference	0.3	1.2	6.3	-0.3	0.4	-0.4	-0.1	2.5	-0.7	-1.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.2	0.5	1.1	0.8	-0.1	-0.4	0.3	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	1.0	-0.1	0.5	1.2	0.6	1.0	0.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.1	-0.6	0.8	-0.2	-0.4	-1.1	-0.8	0.6
Number of live births	0.3	0.4	1.5	-0.1	-1.2	-0.2	0.8	0.9	-0.0	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.5	0.1	-0.6	-0.1	0.4	0.8	0.1	-1.2
Depression (self-reported)	0.3	0.4	1.6	-0.6	-0.2	-1.3	-0.2	-0.8	-0.0	0.6
Pulse wave Arterial Stiffness index	0.3	0.3	1.4	-0.3	0.4	1.0	-0.1	0.3	-0.1	-1.2
Headache pain in last month	0.3	0.6	1.3	-1.1	-0.9	-1.1	-0.6	0.1	-0.8	-0.5
Glaucoma (self-reported)	0.3	0.4	1.2	-0.1	0.9	-0.3	-1.1	0.7	-0.4	0.0
Gout (self-reported)	0.3	0.4	2.5	-0.3	-0.1	0.2	-0.6	1.6	-0.4	0.1
Medication: Amlodipine	0.3	0.4	0.9	-0.8	-1.0	-0.2	-0.7	0.0	-0.9	0.1
High blood pressure (siblings)	0.3	0.4	1.3	-1.1	0.1	-0.0	-0.4	0.5	-0.9	-0.9
Exposure to tobacco smoke outside home	0.3	0.4	1.2	-0.0	0.9	1.1	0.6	-0.6	0.2	0.8
Worry too long after embarrassment	0.3	0.6	3.2	-0.1	-1.8	-0.2	-0.2	0.8	-0.0	-0.7
Number of children fathered	0.3	0.3	0.8	0.4	-0.3	0.4	0.7	0.9	0.1	0.9
Neck or shoulder pain in last month	0.3	0.4	1.7	0.2	-1.3	-0.3	0.8	0.3	0.4	-0.8
Supplements: Vitamin C	0.3	0.3	1.7	-0.2	-1.3	-0.2	0.6	0.3	-0.1	0.7
Illnesses of siblings: Diabetes	0.3	0.4	1.0	1.0	0.2	1.0	1.0	-0.1	0.5	0.4
Eye problems/disorders: Cataract	0.3	0.4	1.3	0.1	-1.1	-0.7	-0.6	-0.1	-0.4	0.7
Mother’s age at death	0.3	0.4	1.1	-0.7	-0.3	0.2	-1.1	-0.9	-0.6	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	-1.0	-0.4	-0.9	-1.1	0.2	-0.6	-0.1
Medication: Lisinopril	0.3	0.3	1.0	-0.2	-0.3	0.8	-0.1	1.0	-0.5	-0.8
Cholesterol lowering medication	0.3	0.5	1.4	-0.8	-0.7	-0.2	-0.4	0.6	-0.9	-1.2
Pain experienced in last month	0.3	0.4	0.7	0.8	0.9	0.6	-0.6	-0.7	0.5	0.8
Supplements: Calcium	0.3	0.4	1.2	0.3	-0.7	-0.8	0.3	-0.6	0.5	1.1
Alzheimer’s Disease (in mother)	0.2	0.3	1.1	-0.5	0.2	0.0	-0.8	-1.0	-0.5	0.0
Blood Red Count	0.2	2.1	5.9	0.8	2.4	2.4	-1.4	1.6	0.0	0.3
Systolic Blood Pressure	0.2	0.9	5.2	0.2	0.6	2.3	-0.1	1.1	0.4	0.1
Allergy or Eczema	0.2	0.5	1.1	0.6	1.1	0.6	-0.1	-0.8	0.6	1.0
Cardiovascular Disease	0.2	0.6	2.1	0.3	1.0	1.5	0.1	1.2	0.2	-0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.9	0.0	-0.2	-0.1	-0.5	1.4	-0.5	-0.7
Current tobacco smoking	0.2	0.3	0.9	0.3	-0.5	0.2	0.9	0.3	0.2	0.9
Nervous feelings	0.2	0.3	0.9	-0.0	0.0	0.5	-0.6	1.0	-0.0	0.9
Had other major operations	0.2	0.3	0.9	0.0	-0.5	0.2	0.6	-0.9	0.3	-0.6
Financial difficulties in last 2 years	0.2	0.3	0.9	-0.5	-0.0	-0.8	-0.4	0.9	-0.6	-0.5
Fluid intelligence score	0.2	0.5	1.3	0.9	-0.4	1.0	0.3	-0.6	1.2	-0.4
Illnesses of siblings	0.2	0.3	0.8	0.9	0.2	0.2	0.2	-0.2	0.8	0.7
Noisy workplace	0.2	0.3	1.1	0.4	0.5	0.2	0.5	-1.1	0.1	-0.4
Asthma	0.2	0.3	0.8	0.1	0.3	-0.8	-0.2	-0.8	-0.4	0.9
Medication: Cholesterol lowering	0.2	0.3	1.4	0.0	0.3	0.5	-0.4	1.2	-0.3	-0.6
Wheeze or whistling in the chest in last year	0.2	0.4	1.9	0.5	0.6	0.1	1.4	0.3	0.7	0.2
Pulse wave peak to peak time	0.2	0.2	1.0	0.6	0.1	-0.6	0.1	-0.3	0.3	1.0
Shortness of breath walking on level ground	0.2	0.2	0.8	-0.4	-0.8	-0.9	0.2	0.1	-0.5	-0.3
Eye problems/disorders: None of the above	0.2	0.2	1.2	0.2	0.0	0.5	1.1	-0.1	0.7	0.1
Medication: Allopurinol	0.2	0.3	0.9	-0.5	0.4	0.6	-0.9	0.2	-0.5	-0.2
Medication: Seretide 50 evohaler	0.2	0.3	0.9	0.6	0.2	0.2	0.9	0.7	0.4	0.3
Heart disease (mother)	0.2	0.2	0.8	-0.9	-0.5	0.1	-0.1	0.3	-0.6	-0.4
Suffer from ‘nerves’	0.2	0.3	0.9	-0.2	-0.6	0.6	0.5	0.3	0.6	0.9
Overall health rating	0.2	0.4	1.8	0.2	0.1	0.5	0.9	1.4	0.1	-0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.6	0.1	-0.7	-0.1	-0.1	0.3	0.2	1.3
Average weekly red wine intake	0.2	0.2	0.7	0.2	0.6	0.8	-0.6	-0.7	0.0	0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	0.4	-0.5	-0.8	-0.0	0.7	0.3	0.2
Smoking status: Current	0.2	0.4	1.2	0.6	0.1	0.4	1.0	0.1	0.5	1.1
Guilty feelings	0.2	0.3	0.9	-0.6	-0.2	-0.7	0.0	1.0	-0.7	-0.7
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	0.2	0.8	-0.1	-0.8	0.0	-0.2	0.6
Medication: Atorvastatin	0.2	0.2	0.8	-0.1	-0.9	-0.1	-0.5	0.6	-0.3	0.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	0.4	-0.2	0.6	-0.2	0.2	-0.1	0.2
Respiratory disease	0.1	0.2	1.3	0.1	-0.6	-1.1	0.1	-0.4	-0.3	-0.1
Tanning	0.1	0.8	3.3	-0.9	-0.4	0.2	-0.0	0.9	-1.1	-1.8
Hearing difficulty/problems: Yes	0.1	0.1	0.3	0.4	0.5	-0.4	0.3	0.5	0.3	-0.2
Relative age of first facial hair	0.1	0.2	1.0	0.0	-0.0	0.2	0.4	-0.7	0.5	1.0
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.5	0.3	-0.3	0.3	-0.5	-0.7	0.2	-0.6
High blood pressure	0.1	0.3	1.2	0.5	0.4	1.1	0.6	0.8	0.4	0.0
Supplements: Glucosamine	0.1	0.1	0.4	-0.1	-0.6	0.3	0.2	0.2	0.4	-0.6
Breastfed as a baby	0.1	0.2	0.6	-0.8	-0.3	0.3	-0.2	0.4	-0.4	0.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	0.3	-0.2	0.4	0.9	0.8	0.7	-0.5
Pulse wave reflection index	0.1	0.2	0.6	-0.3	-0.1	-0.2	0.7	-0.5	0.1	-0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.4	0.5	0.1	-0.3	0.1	-0.4	-0.3
Birth weight	0.1	0.3	1.4	-0.2	-0.1	-1.2	-0.3	-0.5	-0.3	-0.4
Medication: Ibuprofen	0.1	0.2	0.6	0.4	0.1	0.0	0.6	0.2	0.3	-0.8
Comparative height size at age 10	0.1	0.4	1.0	0.1	0.7	1.0	-0.6	0.7	-0.1	-0.9
Hypertension (Self-reported)	0.1	0.2	0.7	0.3	0.1	0.8	0.2	0.8	0.2	0.2
Illnesses of father: Heart disease	0.1	0.2	0.7	-0.6	0.3	0.2	0.1	0.3	-0.4	-0.9
Medication for cholesterol	0.1	0.2	0.3	0.5	-0.4	-0.3	0.4	-0.6	0.6	0.1
Mineral and other dietary supplements	0.1	0.1	0.5	0.5	0.7	0.3	0.5	-0.3	-0.1	0.2
Asthma (self-reported)	0.1	0.2	0.7	0.1	-0.0	-0.8	-0.1	-0.8	-0.4	0.8
Medication: Gliclazide	0.1	0.1	0.4	-0.3	0.7	0.4	-0.4	0.0	-0.1	-0.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.4	-0.1	0.3	0.6	0.1	0.4	-0.2	-0.4
Medication: Blood pressure	0.1	0.3	0.7	-0.7	0.1	-0.4	-0.7	-0.4	-0.8	0.1
Medication: Bendroflumethiazide	0.1	0.2	0.7	0.3	0.4	0.9	0.6	-0.3	0.2	0.3
Fractured/broken bones in last 5 years	0.1	0.1	0.5	0.7	-0.2	-0.2	0.3	0.3	0.2	0.3
Age started oral contraceptive pill	0.1	0.1	0.7	-0.4	0.2	-0.2	0.0	0.4	0.1	-0.8
Basal cell carcinoma (self-reported)	0.1	0.1	0.5	0.3	0.2	-0.4	-0.7	0.2	0.3	0.4
Hair Pigment	0.0	1.3	6.3	-0.1	-2.5	-1.6	0.4	-0.6	-0.4	0.9

Hub : Genes

SHISA5

Models

Trait associations