TWAS hub - GPR65

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2970	0.0860	3.6e-04	0.087	NA	0.074	NA	0.130	9.0e-04	NA	2.0e-03	NA	5.1e-05
2	GTEx	Cells Transformed fibroblasts	0.1080	0.0360	5.1e-04	0.035	NA	0.019	NA	0.043	1.2e-03	NA	1.4e-02	NA	3.7e-04
3	YFS	Blood	0.1045	0.0230	0.0e+00	0.103	0.089	0.119	0.103	0.117	7.4e-32	1.1e-27	5.7e-37	7.6e-32	3.7e-36
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0860	0.0395	2.0e-05	0.012	0.062	0.049	NA	0.047	1.3e-02	1.8e-07	3.4e-06	NA	5.2e-06
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0704	0.0361	1.4e-04	0.003	0.027	0.012	NA	0.012	1.3e-01	5.0e-04	1.5e-02	NA	1.5e-02
6	TCGA	Brain Lower Grade Glioma	0.0345	0.0172	1.9e-05	0.022	0.036	0.035	NA	0.035	1.3e-03	4.9e-05	7.2e-05	NA	7.5e-05
7	TCGA	Lung Adenocarcinoma	0.0549	0.0289	1.6e-03	0.015	0.029	0.024	NA	0.017	5.7e-03	2.0e-04	7.4e-04	NA	3.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Crohns Disease (2017)	4.3	9.4	26.5	-0.8	-0.0	-0.6	5.2	3.0	4.2	3.4
Irritable Bowel Disease (IBD)	4.2	10.0	28.8	0.3	0.5	-0.6	5.4	3.6	3.0	4.3
Primary Biliary Cirrhosis	3.9	5.5	13.6	-1.9	2.4	3.7	0.8	-2.4	-2.8	-1.0
Heart disease (mother)	3.7	4.5	11.2	-3.3	1.2	2.5	0.0	-2.7	-0.4	-2.3
Financial situation satisfaction	3.5	4.3	8.3	2.3	0.2	-1.5	2.1	2.8	1.5	2.9
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.8	8.5	-1.1	-0.8	1.0	-2.9	-2.4	-1.9	-2.4
Ulcerative Colitis (UC)	3.1	5.7	13.9	1.5	0.7	-0.8	3.4	3.2	0.9	3.7
Family relationship satisfaction	3.0	3.7	9.1	1.7	2.0	0.6	3.0	1.9	0.3	2.5
Crohns Disease (2012)	2.9	4.6	11.7	-0.8	-0.1	-0.7	3.4	2.0	3.3	2.2
Ulcerative Colitis	2.8	4.1	7.7	1.9	-1.1	-2.1	1.6	2.7	1.4	2.8
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	6.1	-2.5	1.4	2.3	-0.5	-1.7	-0.4	-1.8
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	10.0	-0.3	3.2	2.3	2.7	0.7	-1.3	1.9
Medication: Gliclazide	2.6	3.0	8.8	0.2	-1.5	-2.0	1.1	1.9	3.0	1.1
Commuting to job workplace: Cycle	2.6	3.1	8.1	0.3	-2.9	-2.3	-2.6	-0.5	0.2	-1.1
Depressed Affect (Nagel 2018)	2.4	5.0	16.4	0.7	-0.7	-1.6	2.5	2.3	4.1	2.0
Chronic bronchitis/emphysema (mother)	2.4	2.8	5.0	0.7	2.0	0.8	2.1	2.1	-1.1	2.2
Number of self-reported non-cancer illnesses	2.4	4.2	10.4	1.6	1.7	-0.3	2.2	3.2	-0.1	2.9
Fed-up feelings	2.3	4.1	12.5	-0.3	-0.1	-0.6	2.8	2.2	3.5	1.8
Commuting to job workplace: Car/motor vehicle	2.3	2.6	7.1	0.1	2.7	1.4	2.6	0.3	-0.2	1.5
Loneliness, isolation	2.3	3.2	7.4	0.8	0.1	-0.7	2.7	1.9	2.4	2.2
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	8.8	-0.7	1.5	0.7	3.0	1.3	1.4	1.6
Number of full sisters	2.1	2.6	5.7	2.1	0.3	-1.4	1.0	2.4	0.2	2.2
Average weekly champagne plus white wine intake	2.1	2.8	5.8	-0.8	0.9	1.8	-1.4	-2.4	-2.4	-1.5
Ovarian Cancer	2.0	2.6	8.6	1.2	2.4	1.1	0.2	0.4	-2.9	1.2
Had menopause	2.0	2.5	6.0	1.1	1.1	0.4	2.1	2.4	0.1	2.1
Medication: Lansoprazole	2.0	2.2	4.5	1.9	-0.7	-2.1	-1.2	1.9	-0.9	1.1
Heart attack/myocardial infarction (self-reported)	2.0	2.6	6.9	1.6	0.4	-1.2	1.0	2.6	1.3	2.0
Alzheimer’s Disease (in father)	1.9	2.0	4.7	-0.8	0.8	1.6	-1.0	-2.2	-1.7	-1.3
BMI	1.9	10.8	34.8	-2.7	2.7	2.2	5.9	1.0	4.1	1.8
Chronic bronchitis/emphysema (father)	1.9	2.2	6.4	-0.1	0.4	0.5	2.5	1.0	2.5	1.2
Irritability	1.9	3.3	5.8	2.2	-0.4	-1.8	1.4	2.3	1.3	2.4
High blood pressure (mother)	1.8	2.6	6.8	0.7	1.2	-0.2	2.2	2.0	0.4	2.6
Mouth/teeth dental problems: Dentures	1.8	3.0	6.1	1.4	-1.2	-2.2	-0.1	2.4	2.5	0.8
Hypothyroidism/myxoedema (self-reported)	1.8	3.5	9.2	-1.4	3.0	3.0	1.4	-1.1	-1.2	-0.3
Friendships satisfaction	1.8	2.2	7.0	-0.6	1.8	2.0	2.7	-0.5	0.6	0.5
Medication for hormone replacement therapy	1.7	1.9	3.8	2.0	1.3	0.1	1.3	1.4	-0.6	1.9
Current tobacco smoking	1.7	2.9	6.4	1.2	-0.2	-1.3	1.6	2.5	1.6	2.3
Heart attack	1.7	2.1	5.9	1.4	0.5	-1.0	1.0	2.4	1.3	1.8
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	5.8	0.1	1.8	0.9	2.4	1.0	-0.8	2.0
Noisy workplace	1.7	2.2	4.6	0.4	0.4	-0.9	1.9	2.1	1.2	2.0
Smoking status: Current	1.7	2.7	6.0	1.1	-0.0	-1.2	1.7	2.4	1.4	2.3
High blood pressure	1.6	4.4	12.2	-0.6	2.6	1.9	3.5	1.7	0.9	2.0
Supplements: Glucosamine	1.6	2.1	9.1	1.6	1.1	0.2	-0.8	-0.9	-3.0	0.2
Father’s age at death	1.6	2.1	5.3	-0.7	2.0	1.9	0.5	-1.1	-2.3	-0.1
Happiness	1.6	1.9	4.0	1.9	0.8	-0.3	1.8	1.3	-0.4	2.0
Exposure to tobacco smoke at home	1.6	1.8	5.7	0.0	0.4	0.0	2.4	1.1	2.1	1.1
Exposure to tobacco smoke outside home	1.6	2.2	5.2	0.4	0.2	-0.4	2.3	1.7	1.7	2.0
Wheeze or whistling in the chest in last year	1.6	2.8	5.4	0.7	1.9	0.7	2.0	2.2	-0.5	2.3
Supplements: Fish oil (including cod liver oil)	1.6	2.1	4.8	1.6	0.3	-1.7	1.0	1.7	0.1	2.2
Risk taking	1.6	2.4	6.7	-0.1	2.6	2.1	2.1	0.3	-0.0	0.9
Vascular/heart problems diagnosed by doctor	1.6	4.5	11.5	0.0	-2.2	-1.0	-3.4	-2.5	-1.5	-2.4
Bipolar Disorder (2018)	1.5	2.4	6.0	1.7	-2.1	-2.4	-1.4	1.1	0.6	0.2
Depression (Nagel 2018)	1.5	2.2	6.4	-0.7	-1.3	-1.7	1.3	1.3	2.5	1.0
Lupus	1.5	2.3	6.4	-1.0	0.3	0.8	2.5	1.1	2.3	1.0
Allergy or Eczema	1.5	4.0	9.7	2.1	1.5	-0.3	2.4	2.4	-0.3	3.1
Mouth/teeth dental problems	1.5	2.2	6.3	-1.3	-0.8	0.3	-1.6	-2.5	-0.7	-2.0
Falls in the last year	1.5	2.1	4.2	1.7	-0.1	-1.6	1.0	1.8	0.7	2.1
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.4	0.9	1.8	1.8	1.4	0.2	-1.7	1.0
Birth weight	1.5	3.3	8.3	-1.6	1.5	2.9	0.2	-2.2	-1.9	-1.3
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.1	1.2	1.6	0.7	1.5	1.2	-1.1	1.8
Mood swings	1.5	2.8	8.0	-0.1	-0.1	-0.6	2.3	1.7	2.8	1.6
Mineral and other dietary supplements	1.5	2.0	5.3	-2.1	0.4	2.3	0.7	-1.0	1.0	-1.3
Pain type(s) experienced in last month: Hip pain	1.5	1.8	4.1	0.3	1.1	-0.1	2.0	2.0	0.7	1.8
Medication: Bendroflumethiazide	1.5	2.3	7.3	0.4	2.7	1.5	1.9	1.1	-0.6	1.2
Schizophrenia vs Biploar Disorder	1.4	1.8	4.9	-2.2	0.2	1.7	0.2	-1.5	0.4	-1.4
Mean Putamen Volume	1.4	1.6	4.5	0.8	-1.1	-1.1	-2.1	-1.3	-1.0	-1.1
Alcohol intake versus 10 years previously	1.4	2.0	5.7	1.4	-1.3	-2.4	-0.7	1.8	0.5	1.0
Lung cancer (father)	1.4	1.6	2.8	1.5	-1.7	-1.6	-0.7	0.8	1.6	0.1
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	6.6	2.6	1.1	-0.4	-0.6	0.3	-2.5	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	2.8	1.7	-0.1	-1.3	1.2	1.5	1.1	1.6
Had major operations	1.4	1.6	2.9	1.0	1.7	0.2	1.0	1.2	-1.4	1.7
Hypothyroidism (self reported)	1.3	2.9	7.1	-1.6	1.7	2.7	0.2	-2.1	-1.2	-1.4
Average weekly spirits intake	1.3	1.6	4.4	-0.9	1.8	2.1	0.4	-1.0	-0.8	-1.0
Relative age of first facial hair	1.3	2.6	10.3	-0.0	0.9	0.9	-1.5	-1.7	-3.2	-0.9
Medication: Co-codamol	1.3	1.5	3.5	0.4	1.3	0.0	1.5	1.7	-0.1	1.9
Pack years adult smoking proportion	1.3	2.0	3.5	1.4	-0.7	-1.8	0.2	1.8	1.9	1.2
Neuroticism score	1.3	2.6	5.5	0.3	-0.2	-0.7	2.3	1.9	2.3	1.9
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	2.9	1.2	-0.6	-1.5	1.1	1.7	0.7	1.7
Hypertension (Self-reported)	1.3	3.7	10.1	-0.4	2.1	1.4	3.2	2.0	1.0	2.0
Medication for cholesterol	1.3	1.9	5.7	-0.5	-1.7	-0.8	-2.4	-0.8	-0.8	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	4.2	-0.4	-2.0	-1.5	-1.1	-0.1	1.4	-1.0
Hearing aid user	1.3	1.5	3.2	-1.5	-1.0	0.4	-0.8	-1.4	1.1	-1.8
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.9	1.2	-1.1	-1.8	0.1	0.8	2.0	0.5
Neuroticism (Nagel 2018)	1.2	2.9	7.5	0.4	-1.2	-1.9	1.6	1.8	2.7	1.5
Body Mass Index (BMI) (2010)	1.2	1.7	4.7	0.2	1.4	0.0	2.2	1.4	0.0	1.8
Blood Eosinophil Count	1.2	9.6	18.7	0.9	-0.8	-2.0	4.3	3.5	4.3	3.5
Medication: Metformin	1.2	1.7	7.4	-0.9	-1.5	-0.9	0.0	-0.0	2.7	-0.6
Medication: Ramipril	1.2	1.6	5.0	-0.9	0.8	0.6	2.0	-0.1	2.2	0.3
Number of live births	1.2	1.7	4.8	-2.2	1.1	1.4	1.1	-0.7	1.1	-0.7
Eye problems/disorders: Cataract	1.2	1.4	2.5	-0.7	1.5	1.6	0.8	-1.3	-1.6	0.0
Medication: Blood pressure	1.2	2.3	6.6	-0.5	2.2	1.3	2.6	0.9	0.7	1.3
Alcohol drinker status: Previous	1.2	1.4	3.2	0.8	-0.3	-1.5	0.4	1.8	-0.5	1.7
Neuroticism (2016)	1.1	1.6	5.7	0.6	-0.9	-1.3	0.8	1.3	2.4	0.8
Townsend deprivation index at recruitment	1.1	1.6	4.0	0.5	0.1	-0.9	1.5	2.0	0.5	1.9
Medication: Blood pressure	1.1	1.9	5.6	-1.0	0.7	0.8	1.9	1.3	2.4	0.4
Guilty feelings	1.1	1.6	4.0	-0.3	-0.8	-1.3	1.2	1.4	2.0	1.1
Myopia	1.1	1.5	3.3	0.8	0.6	-0.3	1.8	1.7	1.0	1.6
Heart disease (siblings)	1.1	1.4	2.8	-1.1	1.4	1.1	1.7	0.2	1.4	0.2
Alzheimer’s Disease (in mother)	1.0	1.2	3.0	0.3	-0.8	-0.6	-1.7	-1.2	-1.3	-0.9
Breast Cancer	1.0	2.3	4.6	-2.1	1.5	1.7	1.9	0.1	1.7	-0.2
Diabetes (mother)	1.0	1.2	3.2	-1.5	1.2	1.8	1.3	-0.1	0.4	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.8	-1.1	0.0	-0.2	1.9	0.4	1.8	0.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.5	-1.3	0.8	1.9	1.2	-0.1	0.5	-0.3
Serious illness, injury or assault to yourself	1.0	1.3	6.2	-0.7	-0.7	-0.7	0.5	1.0	2.5	0.0
Hayfever, allergic rhinitis or eczema	1.0	2.3	5.8	0.6	1.4	0.6	2.4	1.7	-0.0	2.2
Medication: Levothyroxine sodium	1.0	1.7	5.6	-0.4	2.4	2.0	1.4	-0.1	-0.3	0.5
Arm fat percentage (right)	1.0	3.9	11.5	-1.6	0.8	0.4	3.2	1.0	3.4	1.1
Pulse wave Arterial Stiffness index	1.0	1.2	3.0	-1.7	-0.1	0.8	-0.4	-1.3	0.1	-1.7
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.1	-1.1	0.0	0.4	1.7	0.8	2.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.4	0.1	1.3	0.3	1.8	1.2	-0.1	1.7
Pulse wave peak to peak time	1.0	1.1	3.0	1.7	0.1	-0.7	0.5	1.2	-0.1	1.7
Angina (self-reported)	1.0	1.3	4.8	1.0	-0.1	-0.9	0.2	2.2	1.0	1.2
Whole body fat mass	1.0	4.0	13.0	-1.1	1.5	0.6	3.6	1.2	2.7	1.6
Medication: Aspirin	1.0	1.3	2.8	-0.4	0.6	0.2	1.4	1.6	1.7	0.8
Arm fat percentage (left)	1.0	4.0	12.3	-1.4	1.3	0.6	3.5	1.2	2.8	1.5
Wears glasses or contact lenses	1.0	1.2	3.0	-1.7	0.5	1.5	0.4	-1.0	0.4	-1.1
Average weekly beer plus cider intake	1.0	1.4	2.7	1.1	1.4	0.2	1.1	1.6	-0.6	1.6
Alzheimer’s Disease (including proxy)	0.9	1.4	3.2	1.1	-0.7	-0.4	-1.8	-1.4	-1.5	-0.7
HDL Cholesterol	0.9	1.5	3.0	-1.1	-1.0	0.3	-1.4	-1.7	-0.3	-1.7
Cardiovascular Disease	0.9	2.9	7.5	0.3	1.9	1.2	2.7	1.6	0.0	2.2
Lung FVC	0.9	4.7	14.5	-1.0	1.4	2.5	-1.4	-2.4	-3.8	-1.2
Chronotype (morning person)	0.9	2.1	5.6	2.4	0.3	-1.2	0.2	2.4	-0.1	1.5
Angina	0.9	1.2	4.6	0.9	0.0	-0.7	0.2	2.1	1.0	1.1
Trunk fat mass	0.9	3.8	12.2	-1.0	1.6	0.7	3.5	1.1	2.6	1.5
Waist circumference	0.9	3.4	10.4	-1.9	1.7	1.6	3.2	-0.2	1.9	0.7
Past tobacco smoking	0.9	1.6	4.5	-0.3	-2.1	-1.5	-1.2	-0.4	1.4	-0.9
Nervous feelings	0.9	1.6	4.4	1.5	-1.8	-2.1	-0.8	0.8	0.1	0.6
Qualifications: A levels/AS levels or equivalent	0.9	2.0	5.7	1.8	-0.3	-0.8	-1.9	-0.8	-2.4	-0.2
Illnesses of mother	0.9	1.1	3.0	0.2	-0.6	0.4	-1.4	-1.7	-0.6	-1.4
Arm fat mass (right)	0.9	3.7	11.0	-2.0	1.2	1.0	3.3	0.4	2.7	0.9
Body fat percentage	0.9	3.6	11.0	-0.9	1.6	0.6	3.3	1.3	2.5	1.6
Medication: Ibuprofen	0.9	1.1	2.2	1.2	-0.2	-1.2	1.0	1.3	0.3	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	5.2	-0.6	-1.0	-0.8	0.4	0.5	2.3	0.2
Illnesses of siblings: Diabetes	0.9	1.1	2.2	-0.4	1.4	0.6	1.5	1.2	0.9	0.7
Smoking status: Previous	0.9	1.4	3.9	-0.7	1.8	2.0	0.6	-0.5	-1.2	-0.2
Medication: Aspirin	0.9	1.2	2.3	-0.4	0.9	0.5	1.4	1.5	1.5	0.7
Miserableness	0.9	1.5	6.7	-0.8	-0.8	-0.6	1.3	0.6	2.6	0.3
Illnesses of father: High blood pressure	0.9	1.1	2.7	0.0	1.7	1.0	1.1	0.6	-1.1	1.1
Number of operations (self-reported)	0.9	1.4	3.0	1.7	0.6	-0.9	-0.3	1.1	-1.6	1.3
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.8	-0.1	-1.7	-0.7	-1.5	-0.5	0.5	-1.2
Fractured/broken bones in last 5 years	0.9	1.2	2.9	1.6	-1.2	-1.7	-0.6	0.8	-0.1	0.7
Unable to work because of sickness or disability	0.9	1.1	2.7	1.0	0.6	-0.3	0.2	1.6	-1.2	1.6
Leg fat mass (left)	0.9	3.4	11.2	-1.3	1.5	1.0	3.3	0.8	2.3	1.3
Neuroticism	0.8	1.9	3.3	0.9	-0.7	-1.5	1.3	1.8	1.6	1.6
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.1	1.0	0.7	0.2	1.0	1.4	-0.8	1.4
Trunk fat percentage	0.8	3.4	9.8	-0.7	1.3	0.3	3.1	1.3	2.7	1.4
Relative age voice broke	0.8	1.3	5.0	0.2	1.2	1.1	-0.9	-0.6	-2.2	-0.3
Body mass index (BMI)	0.8	3.4	10.3	-2.1	1.1	1.0	3.2	0.3	2.5	0.8
Allergy	0.8	1.8	4.2	0.8	-1.7	-1.8	-2.0	-0.7	0.1	-1.0
Tense / ‘highly strung’	0.8	1.3	3.6	0.4	-0.0	0.0	1.9	1.2	1.6	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.7	-1.4	0.7	0.4	1.9	0.5	1.4	0.5
Headache pain in last month	0.8	1.4	2.5	1.6	-0.7	-1.6	0.1	1.6	0.5	1.1
Health satisfaction	0.8	1.0	2.1	0.5	0.9	0.1	1.5	1.1	1.2	1.1
Qualifications: College or University degree	0.8	2.6	5.7	0.9	-0.6	-0.3	-2.4	-2.2	-2.1	-1.3
Eye problems/disorders: None of the above	0.8	0.9	3.0	0.0	-1.4	-0.6	-0.7	0.3	1.7	-0.8
Medication: Omeprazole	0.8	1.0	2.6	0.4	1.6	0.5	0.7	0.6	-1.4	1.0
Leg fat mass (right)	0.8	3.1	10.0	-1.4	1.4	1.0	3.2	0.6	2.3	1.1
Overall health rating	0.8	1.8	3.7	-1.0	0.7	0.0	1.8	1.9	1.6	1.3
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.3	-1.2	-0.2	0.3	-0.6	-1.8	0.0	-1.4
Back pain experienced in last month	0.8	1.1	3.1	-0.3	0.6	-0.2	1.5	1.8	0.5	1.3
Arm fat mass (left)	0.8	3.1	9.7	-1.7	1.2	0.9	3.1	0.4	2.5	0.9
Ever taken oral contraceptive pill	0.8	0.9	1.8	1.1	-0.0	-1.1	-0.0	1.4	-0.6	1.3
HbA1C	0.7	0.8	2.7	0.6	-0.6	-1.7	0.5	0.5	0.7	0.8
Smoking Status	0.7	1.6	3.2	0.6	1.8	1.0	1.3	1.2	-1.1	1.5
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.4	-1.2	-0.4	-0.3	1.5	0.4	1.4	0.8
Severe depression (siblings)	0.7	0.8	1.8	1.2	1.3	0.8	0.4	-0.5	-1.3	0.4
Multivitamins +/- minerals	0.7	0.9	1.4	-1.2	-1.0	-0.5	-1.2	-1.0	-0.6	-1.0
Forced vital capacity (FVC)	0.7	2.6	8.3	-0.1	1.6	1.8	-0.1	-2.0	-2.9	-0.3
Hair/balding pattern: Pattern 3	0.7	1.1	2.9	1.1	1.6	0.7	-0.1	0.3	-1.7	0.6
Medication: Cholesterol lowering	0.7	1.0	4.2	0.7	0.3	-0.3	0.4	2.0	1.1	1.0
Depression (self-reported)	0.7	0.8	2.8	0.2	-0.1	-0.2	1.7	0.5	1.4	0.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.5	-0.1	-1.6	-0.6	-1.1	-0.4	0.9	-0.9
Suffer from ‘nerves’	0.7	1.1	2.2	1.1	-0.4	-1.5	0.6	1.5	0.4	1.4
Supplements: Vitamin C	0.7	0.8	2.2	0.4	-0.3	-0.9	0.8	1.5	0.7	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	5.0	0.6	1.3	1.2	-0.0	-1.1	-2.2	0.1
Medication: Atorvastatin	0.7	0.9	2.3	1.0	0.2	-0.3	0.7	1.5	1.1	1.1
Pack years of smoking	0.7	1.0	1.8	1.2	-0.2	-1.1	0.1	1.3	1.2	0.9
Major Depression (MDD)	0.6	0.7	3.0	-1.7	-0.2	0.3	0.0	-0.7	0.6	-1.0
Fasting Glucose	0.6	0.7	1.7	-0.7	-1.3	-0.7	-0.5	-0.4	1.2	-0.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.0	0.7	-0.4	-1.4	-0.0	1.4	0.1	0.9
Medication: Atenolol	0.6	0.8	1.6	0.2	1.3	0.4	1.1	1.2	0.4	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.6	1.1	-0.0	-0.6	1.0	1.2	1.0	1.3
Had other major operations	0.6	0.7	1.5	0.5	-1.2	-1.1	-0.5	0.1	1.2	-0.4
Pain all over the body in last month	0.6	0.7	1.4	0.4	0.8	0.2	0.8	1.2	-0.5	1.2
Fluid intelligence score	0.6	1.3	3.0	0.3	-0.6	-0.1	-1.7	-1.7	-1.4	-1.0
Illnesses of siblings	0.6	0.9	2.1	1.1	-0.8	-0.9	-1.4	-0.2	-1.2	-0.1
Weight	0.6	2.7	9.6	-1.5	1.5	1.0	3.1	0.2	1.6	1.0
Time employed in main current job	0.6	0.7	2.2	0.3	-1.5	-0.9	-1.1	0.2	0.1	-0.6
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	5.3	-0.2	1.5	1.6	0.0	-1.7	-2.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	8.0	0.1	1.4	1.4	-0.3	-1.5	-2.8	-0.1
Breastfed as a baby	0.6	0.7	1.8	0.7	1.0	-0.1	0.7	1.3	-0.4	1.1
Birth weight of first child	0.6	1.2	2.2	-1.2	-0.6	0.2	-1.5	-1.3	-0.9	-1.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.9	0.4	-0.5	-0.4	-1.0	-1.7	-1.7	-0.5
Shortness of breath walking on level ground	0.6	0.7	1.7	0.5	-0.2	-0.9	0.4	1.3	1.1	0.8
Emphysema/chronic bronchitis	0.6	0.7	1.4	0.4	1.2	1.0	0.9	0.9	0.2	0.6
Commuting to job workplace: Public transport	0.6	0.7	1.4	-0.8	0.2	1.1	-0.3	-1.2	-0.9	-0.9
Leg fat percentage (left)	0.6	2.3	6.9	-1.3	1.2	0.9	2.6	0.6	2.1	0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.4	-0.4	1.6	1.0	0.6	-0.2	-1.1	0.3
Bipolar Disorder or Schizophrenia	0.5	1.2	3.0	1.0	-1.4	-1.7	-1.4	0.3	-0.4	0.1
Worry (Nagel 2018)	0.5	1.0	2.6	0.6	-1.6	-1.6	-0.1	0.9	0.7	0.4
Bipolar Disorder (2011)	0.5	0.5	1.0	0.7	-0.8	-1.0	-0.9	-0.3	-0.4	-0.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.6	0.3	0.4	-0.4	1.3	0.8	1.6	1.1
Number of treatments/medications taken	0.5	1.0	3.6	0.6	0.3	-0.5	0.8	1.9	0.7	1.2
Hearing difficulty/problems: Yes	0.5	0.7	1.7	-1.3	0.5	1.1	0.3	0.1	1.2	-0.6
Diabetes (father)	0.5	0.6	1.6	-1.0	0.9	0.6	1.3	0.1	0.4	0.1
Stomach or abdominal pain in last month	0.5	0.6	1.9	0.6	0.1	-0.7	-1.3	0.1	-1.4	0.0
Qualifications: None of the above	0.5	1.0	2.4	-1.0	-0.2	-0.5	1.0	1.3	1.5	0.4
Financial difficulties in last 2 years	0.5	0.7	1.5	0.7	-0.0	-0.5	0.9	1.2	0.8	1.2
Diabetes (self-reported)	0.5	0.7	2.5	-1.2	0.1	0.3	0.9	0.1	1.6	-0.1
Hip circumference	0.5	2.2	8.5	-0.9	1.3	0.7	2.9	0.4	1.5	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.7	0.6	-0.4	-1.3	0.6	1.0	1.2	0.9
Pulse wave reflection index	0.5	0.6	1.5	-0.8	0.1	0.7	-0.7	-1.1	-0.5	-1.2
High blood pressure (siblings)	0.5	0.7	2.2	-0.5	0.3	0.1	1.4	0.7	1.5	0.5
Forced vital capacity (FVC), Best measure	0.5	1.9	8.0	0.0	0.9	1.1	-0.7	-1.7	-2.8	-0.4
Leg fat percentage (right)	0.5	1.9	5.5	-1.3	1.2	1.0	2.3	0.4	1.8	0.7
Medication for pain relief, constipation, heartburn	0.5	0.8	3.2	-0.6	-0.3	0.4	-0.7	-1.8	-0.3	-1.2
Alcohol intake frequency.	0.5	1.2	3.3	-0.0	-0.0	-1.2	1.0	1.8	0.4	1.5
Leg pain on walking	0.5	0.6	1.3	1.1	0.7	-0.6	-0.0	1.1	-0.7	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.4	1.2	-1.1	-0.9	-0.7	0.5	-0.1	0.3
Long-standing illness, disability or infirmity	0.5	0.7	2.0	-0.6	-0.8	-1.4	-0.1	1.0	0.8	0.4
Ever had bowel cancer screening	0.5	0.5	0.9	-0.6	-0.8	-0.0	-1.0	-0.8	-0.6	-0.9
Mother’s age at death	0.5	0.7	2.0	1.4	0.1	-0.5	0.2	1.0	-0.4	1.1
Medication: Paracetamol	0.5	0.8	2.2	-1.5	-0.4	0.7	-0.9	-0.7	0.1	-1.2
Ever depressed for a whole week	0.5	0.6	1.4	-0.0	-1.1	-0.8	-0.3	0.9	1.2	-0.1
Pain experienced in last month	0.5	0.9	2.6	-0.5	-1.2	0.1	-0.6	-1.6	0.6	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.8	-1.0	0.5	0.6	1.3	0.2	1.0	0.3
Reaction Time	0.4	0.7	2.0	0.6	0.3	-0.5	0.8	1.3	0.2	1.4
Coronary Artery Disease (CAD)	0.4	0.4	1.4	-0.3	-0.2	-0.0	-1.2	-0.5	-0.0	-1.1
Impedance of leg (right)	0.4	2.1	5.7	2.1	0.2	0.0	-2.1	-0.1	-2.4	-0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.2	-0.3	-1.1	-0.4	-0.9	-0.8	-0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.3	-1.1	0.5	1.5	-0.2	-1.2	0.1	-1.1
Qualifications: CSEs or equivalent	0.4	0.6	1.7	0.8	-0.3	-0.9	-0.6	0.2	-1.3	0.6
Impedance of leg (left)	0.4	1.9	5.9	2.4	0.2	-0.3	-1.9	0.3	-2.0	0.1
Hair/balding pattern: Pattern 2	0.4	0.6	1.1	-0.8	0.1	0.5	-0.9	-0.8	-1.0	-0.7
Medication: Simvastatin	0.4	0.6	2.1	-0.2	1.4	0.8	0.7	0.7	-0.2	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	0.8	0.8	0.6	-0.4	0.6	-1.0	0.0
Loud music exposure frequency	0.4	0.5	1.2	-0.6	-0.4	-0.2	1.0	0.6	1.1	0.6
Blood clot in the leg (DVT)	0.4	0.6	1.4	-0.9	0.3	0.4	1.2	0.3	1.2	0.2
Gout (self-reported)	0.4	0.5	1.6	0.9	0.9	0.0	-0.6	-0.0	-1.3	0.1
Age at first live birth	0.4	0.8	2.3	0.7	-1.5	-1.2	-1.0	-0.3	0.4	-0.3
Average weekly red wine intake	0.4	0.6	1.5	-0.9	-0.8	-0.4	-0.3	-1.2	0.8	-0.7
Ever smoked	0.4	0.8	1.8	0.9	1.2	0.4	0.5	0.6	-1.3	1.0
LDL Cholesterol	0.3	0.4	1.1	-1.0	-0.1	0.2	0.6	-1.1	0.5	-0.5
Schizophrenia (2014)	0.3	0.6	1.4	0.5	-0.8	-1.0	-1.2	-0.3	-0.9	-0.1
Waist Hip Ratio (WHR)	0.3	1.5	3.4	-1.8	0.3	1.6	0.3	-1.6	0.4	-1.4
Lung FEV1/FVC ratio	0.3	1.4	3.1	-1.7	-0.5	0.3	-0.8	-1.1	1.3	-1.7
Systolic blood pressure, automated reading	0.3	0.8	2.4	-1.2	-0.8	-0.1	0.5	0.2	1.6	-0.6
Vitamin and mineral supplements	0.3	0.4	1.1	0.2	1.1	1.0	0.4	-0.6	-0.3	-0.2
Leg fat-free mass (left)	0.3	1.6	6.1	-1.3	0.8	0.7	2.5	-0.2	1.4	0.7
Maternal smoking around birth	0.3	0.5	1.1	-0.8	0.3	1.0	0.1	-1.0	-0.1	-0.7
Taking other prescription medications	0.3	0.5	1.5	0.7	-0.3	-0.8	-0.1	1.2	0.4	0.5
Leg predicted mass (left)	0.3	1.6	5.9	-1.4	0.9	0.7	2.4	-0.2	1.3	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.9	-0.9	0.4	1.4	-0.3	-1.1	-0.3	-1.0
Worrier / anxious feelings	0.3	0.6	1.6	-1.3	-1.1	-0.4	-0.1	0.2	0.9	-0.4
Prospective memory result	0.3	0.3	0.8	-0.6	0.8	0.9	0.1	-0.5	0.3	-0.5
Length of working week for main job	0.3	0.4	0.8	0.9	-0.2	-0.9	0.4	0.5	0.2	0.7
Medication: Amlodipine	0.3	0.4	1.1	-0.3	0.9	0.2	0.5	1.1	0.7	0.4
Number of full brothers	0.3	0.3	0.9	0.3	-0.9	-0.3	-0.2	0.5	0.9	-0.0
Number of children fathered	0.3	0.4	1.2	-0.4	0.7	1.1	0.0	-0.4	-0.8	-0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.9	-0.3	0.1	-0.0	0.6	0.9	1.0	0.2
Mean time to correctly identify matches	0.3	0.5	1.4	0.5	0.2	-0.6	0.6	1.2	0.5	1.0
Age at last live birth	0.3	0.4	1.1	-0.5	0.5	0.7	0.3	-0.9	-1.1	-0.2
Knee pain experienced in last month	0.3	0.5	2.2	-1.5	0.4	0.5	0.0	-0.5	0.2	-0.6
Illnesses of father: Heart disease	0.3	0.4	0.9	0.4	-0.3	-1.0	-0.2	0.9	0.5	0.4
Leg fat-free mass (right)	0.3	1.7	6.4	-1.2	0.8	0.4	2.5	-0.0	1.5	0.9
Diabetes diagnosed by doctor	0.3	0.5	2.3	-0.6	-0.4	-0.5	0.5	0.3	1.5	0.1
Qualifications: nursing, teaching	0.3	0.5	1.2	0.7	0.1	0.4	-0.7	-1.0	-1.1	-0.3
Commuting to job workplace: Walk	0.3	0.3	0.9	0.1	-1.0	-0.6	-0.6	0.3	0.3	-0.3
Osteoporosis (self-reported)	0.3	0.4	0.8	0.2	-0.9	-0.9	-0.8	0.2	-0.3	-0.2
Osteoarthritis (self-reported)	0.3	0.4	1.1	-0.1	0.5	-0.2	0.3	1.0	-0.9	0.8
Leg predicted mass (right)	0.3	1.7	6.6	-1.1	0.9	0.4	2.6	0.1	1.5	0.9
Alcohol drinker status: Never	0.3	0.3	1.2	-0.2	-0.9	-0.4	0.1	0.0	1.1	-0.2
Basal metabolic rate	0.3	1.5	4.6	-1.5	0.9	0.9	2.1	-0.6	1.1	0.4
Age started oral contraceptive pill	0.3	0.3	1.3	-0.5	-0.5	-0.5	0.2	0.1	1.2	-0.2
Cholesterol lowering medication	0.3	0.5	1.5	-0.1	1.2	0.6	0.7	-0.2	-0.6	0.5
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	0.2	-1.0	-0.6	0.1	0.7	0.7	0.2
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.8	0.7	0.1	-0.5	0.7	0.7	-0.1	1.3
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.3	-0.1	-0.7	-0.2	-0.7	-1.1	-0.2	-0.8
Age at First Birth	0.2	0.3	1.3	-0.4	-1.1	-0.2	-0.2	-0.4	0.6	-0.5
Blood Platelet Count	0.2	2.4	6.0	1.3	-2.0	-2.4	-1.9	0.8	0.5	-0.3
Respiratory disease	0.2	0.3	1.1	-0.4	-0.1	-0.2	0.5	1.1	0.7	0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.6	0.5	0.7	0.5	-0.5	0.1	-0.2
Supplements: Zinc	0.2	0.2	0.4	-0.6	0.6	0.2	0.2	0.5	-0.3	0.3
Sitting height	0.2	1.6	5.1	2.3	0.1	-1.0	-0.8	0.5	-1.9	0.8
Number of incorrect matches in round	0.2	0.3	1.1	0.5	0.3	0.2	-0.3	0.7	-1.0	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	-0.2	-0.8	-0.5	-0.2	0.6	0.5	-0.2
Impedance of arm (right)	0.2	0.8	2.5	1.6	-0.3	-0.9	-1.1	0.8	-0.1	0.1
Trunk fat-free mass	0.2	1.1	2.1	-1.3	1.0	1.2	1.5	-1.1	0.1	0.0
Pulse rate	0.2	0.4	1.9	0.5	0.5	0.1	0.2	1.4	-0.0	0.6
Trunk predicted mass	0.2	1.1	2.0	-1.3	0.9	1.3	1.4	-1.1	0.1	0.0
Hair/balding pattern: Pattern 4	0.2	0.5	2.1	0.1	-0.8	-0.2	0.5	-0.2	1.5	-0.4
Medication: Paracetamol	0.2	0.4	1.4	-0.6	-0.6	0.1	-1.2	-0.1	-0.3	-0.6
Glaucoma (self-reported)	0.2	0.2	0.5	-0.7	0.3	0.4	0.6	0.2	-0.4	0.4
Arm fat-free mass (right)	0.2	1.0	3.3	-0.9	1.1	0.9	1.8	-0.7	0.2	0.5
Comparative body size at age 10	0.2	0.5	2.2	-1.5	-0.7	0.0	0.8	-0.1	0.6	0.3
Neck or shoulder pain in last month	0.2	0.4	1.4	-1.2	0.4	0.7	0.1	-0.3	-0.5	-0.3
Migraine (self-reported)	0.2	0.2	0.8	-0.1	0.1	-0.2	0.3	0.9	0.5	0.6
Arm predicted mass (right)	0.2	0.9	2.7	-1.0	1.1	1.0	1.6	-0.7	0.1	0.4
Chest pain or discomfort	0.2	0.3	1.2	-1.1	-0.6	-0.2	-0.8	0.3	-0.0	-0.4
Whole body fat-free mass	0.2	1.2	3.8	-1.3	0.9	1.0	1.9	-0.7	0.8	0.3
Breast cancer (self-reported)	0.2	0.2	0.6	0.4	0.8	0.6	-0.0	-0.0	-0.4	-0.3
Whole body water mass	0.2	1.2	3.4	-1.4	0.8	1.0	1.9	-0.8	0.7	0.2
Medication: Lisinopril	0.2	0.3	0.8	-0.9	0.1	-0.1	0.5	0.8	0.3	0.3
Arm fat-free mass (left)	0.2	1.0	2.4	-1.5	0.6	0.9	1.3	-1.1	0.6	-0.2
Impedance of whole body	0.2	1.3	4.7	2.2	-0.0	-0.7	-1.5	0.7	-1.0	0.2
Arm predicted mass (left)	0.2	0.9	2.1	-1.4	0.6	0.9	1.5	-0.8	0.9	-0.1
Schizophrenia (2018)	0.1	0.2	1.0	-0.1	-0.1	-0.3	-0.7	-0.4	-1.0	-0.0
Prostate Cancer	0.1	0.1	0.3	-0.5	-0.2	0.2	-0.3	0.1	0.2	-0.5
Rheumatoid Arthritis	0.1	0.1	0.3	-0.0	-0.6	-0.5	0.2	0.2	-0.1	0.3
Triglycerides	0.1	0.1	0.5	0.3	0.2	-0.2	0.7	0.4	0.1	0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	0.1	0.0	-0.2	-0.4	0.7	0.2	-0.0
Blood Red Count	0.1	0.7	1.6	-1.3	0.0	0.2	0.2	-0.9	1.2	-0.9
Blood White Count	0.1	0.8	2.3	1.1	0.8	-0.3	0.3	1.5	0.0	1.1
Heel T-Score	0.1	0.4	0.9	-0.3	0.9	0.8	0.9	0.3	0.7	0.1
Systolic Blood Pressure	0.1	0.7	1.6	-0.3	-0.3	-0.5	1.2	1.3	0.9	0.8
Tanning	0.1	0.8	2.5	1.6	0.1	-0.6	-0.5	1.0	-0.8	0.8
Hand grip strength (left)	0.1	0.3	0.7	0.8	-0.2	-0.8	0.5	0.3	0.3	0.5
Sensitivity / hurt feelings	0.1	0.2	0.6	0.1	-0.4	-0.5	0.7	0.0	-0.3	0.8
Ever had hysterectomy (womb removed)	0.1	0.1	0.5	-0.1	-0.7	-0.2	-0.4	0.1	-0.6	0.1
Hand grip strength (right)	0.1	0.2	0.9	-0.2	-0.6	-0.4	0.5	-0.1	0.9	-0.0
Average weekly fortified wine intake	0.1	0.1	0.3	-0.0	-0.6	-0.3	0.1	-0.1	0.3	0.0
Age when periods started (menarche)	0.1	0.2	0.5	-0.2	0.7	0.5	0.7	-0.2	-0.1	0.4
Alcohol usually taken with meals	0.1	0.1	0.4	0.1	0.1	0.6	-0.2	-0.6	-0.4	-0.2
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.2	0.1	0.5	-0.2	-0.2	-0.2	-0.5
Asthma	0.1	0.2	0.7	-0.8	0.2	0.5	0.2	0.2	-0.0	-0.0
Impedance of arm (left)	0.1	0.6	2.2	1.5	0.3	-0.2	-0.7	0.7	-0.7	0.4
Standing height	0.1	0.9	2.3	1.2	1.3	0.4	0.4	-0.3	-1.5	0.7
Peak expiratory flow (PEF)	0.1	0.2	0.6	0.7	0.7	-0.2	0.4	-0.4	-0.3	0.3
Worry too long after embarrassment	0.1	0.1	0.2	-0.1	-0.4	-0.5	0.3	0.5	0.1	0.5
Medication: Allopurinol	0.1	0.2	0.4	0.6	0.3	-0.5	-0.5	0.6	-0.1	0.2
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.4	0.6	0.2	0.3	0.3	-0.5	0.2
Comparative height size at age 10	0.1	0.4	0.8	0.0	0.8	0.9	-0.1	-0.6	-0.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.9	0.9	0.2	0.1	-0.2	-0.3	-0.6	0.2
Asthma (self-reported)	0.1	0.2	0.8	-0.9	0.1	0.5	-0.0	0.1	-0.0	-0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	-0.7	-0.2	-0.2	0.3	0.4	0.1	0.3
High cholesterol (Self-reported)	0.1	0.2	0.5	-0.0	0.5	0.7	-0.5	0.0	-0.7	-0.2
Diastolic blood pressure, automated reading	0.1	0.2	0.5	-0.4	-0.2	-0.1	0.7	0.7	0.6	0.3
Supplements: Calcium	0.1	0.1	0.6	-0.1	0.1	-0.1	-0.1	0.1	-0.8	0.4
Height	0.0	0.5	2.2	1.5	0.2	-0.8	-0.4	-0.1	-0.5	0.2
Hair Pigment	0.0	0.1	0.4	0.2	-0.3	-0.4	-0.6	0.1	-0.2	-0.2
Pulse rate, automated reading	0.0	0.1	0.2	-0.3	0.4	0.4	0.0	0.3	0.1	-0.1
Illnesses of father: None of the above (group 1)	0.0	0.1	0.3	0.2	-0.2	-0.0	-0.1	-0.2	-0.5	-0.1

Hub : Genes

GPR65

Models

Trait associations