TWAS hub - ITLN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0176	0.0079	0.00480	0.000	0.003	0.002	0.003	0.001	3.3e-01	2.1e-02	0.08000	0.023	1.1e-01
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0396	0.0296	0.00170	0.035	0.024	0.013	NA	0.030	7.4e-05	9.0e-04	0.01100	NA	2.6e-04
3	TCGA	Lung Adenocarcinoma	0.0416	0.0277	0.00027	0.040	0.034	0.030	NA	0.041	1.7e-05	6.7e-05	0.00017	NA	1.5e-05
4	TCGA	Thyroid Carcinoma	0.0500	0.0310	0.00320	0.027	0.031	0.032	NA	0.027	1.2e-03	5.2e-04	0.00044	NA	1.2e-03
5	TCGA	Uterine Corpus Endometrial Carcinoma	0.1270	0.0860	0.00320	0.129	0.114	0.103	NA	0.127	2.0e-04	4.4e-04	0.00084	NA	2.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Irritable Bowel Disease (IBD)	11.0	26.2	32.6	3.4	5.1	5.4	5.6	5.7
Crohns Disease (2017)	9.8	21.5	27.4	2.7	4.7	5.0	5.1	5.2
Ulcerative Colitis	8.3	12.1	13.9	2.7	3.5	3.7	3.7	3.7
Ulcerative Colitis (UC)	6.8	12.7	16.7	2.1	3.5	3.7	4.1	4.0
Crohns Disease (2012)	6.1	9.9	13.0	2.0	3.3	3.3	3.6	3.3
Serious illness, injury or assault of a close relative in last 2 years	4.2	4.8	6.6	-1.3	-1.7	-2.6	-2.6	-2.5
Schizophrenia (2018)	3.6	7.5	8.4	2.7	2.9	2.8	2.7	2.5
Taking other prescription medications	3.1	4.8	7.3	1.0	2.0	2.5	2.4	2.7
High blood pressure (siblings)	3.1	4.5	5.4	1.8	1.9	2.3	2.3	2.2
Medication: Simvastatin	2.8	4.1	7.1	2.7	1.6	1.8	1.8	2.1
Emphysema/chronic bronchitis	2.8	3.1	4.3	1.9	2.1	1.7	1.3	1.7
Nervous feelings	2.5	4.6	6.1	1.1	2.2	2.4	2.3	2.5
Friendships satisfaction	2.5	3.1	5.1	-0.9	-1.7	-1.9	-2.2	-1.7
Medication: Aspirin	2.5	3.2	8.5	-0.8	-2.9	-1.5	-1.8	-1.3
Eye problems/disorders: Diabetes related eye disease	2.4	2.7	3.8	0.9	1.9	1.6	1.8	1.6
Angina (self-reported)	2.4	3.1	4.5	-1.0	-2.1	-1.7	-2.1	-1.6
Schizophrenia (2014)	2.3	5.2	6.9	2.6	2.0	2.2	2.5	2.0
Headache pain in last month	2.3	4.0	5.2	1.4	2.1	2.0	2.3	2.0
Ever had bowel cancer screening	2.3	2.6	3.8	1.7	1.0	1.9	1.5	1.8
Myopia	2.2	3.2	4.2	-1.0	-1.9	-2.0	-1.7	-2.0
Bipolar Disorder or Schizophrenia	2.1	5.1	7.2	2.7	2.3	2.2	2.2	1.9
Hearing difficulty/problems: Yes	2.1	3.1	5.1	0.7	1.7	2.3	1.8	2.0
Maternal smoking around birth	2.1	3.0	3.8	-1.6	-1.6	-1.8	-1.6	-1.9
Number of self-reported non-cancer illnesses	2.1	3.7	6.4	0.1	1.0	2.4	2.3	2.5
Wears glasses or contact lenses	2.1	2.4	3.5	-1.3	1.9	1.3	1.8	1.3
Illnesses of father: High blood pressure	2.1	2.6	5.5	2.4	1.6	1.4	0.6	1.6
Angina	1.9	2.5	4.1	-0.7	-2.0	-1.5	-1.9	-1.3
Prospective memory result	1.8	2.2	3.1	1.7	1.0	1.6	1.3	1.8
Mouth/teeth dental problems: Loose teeth	1.8	2.2	3.7	0.0	-1.5	-1.8	-1.3	-1.9
Fractured/broken bones in last 5 years	1.8	2.4	2.9	-1.5	-1.7	-1.6	-1.4	-1.4
Vitamin and mineral supplements	1.7	2.3	3.1	-0.9	-1.8	-1.6	-1.8	-1.4
High cholesterol (Self-reported)	1.6	2.8	5.4	2.3	1.0	1.6	1.1	2.0
Impedance of arm (left)	1.5	6.9	7.8	2.8	2.7	2.4	2.7	2.5
Leg pain on walking	1.5	1.9	2.4	1.5	1.1	1.5	1.2	1.5
Long-standing illness, disability or infirmity	1.5	2.2	3.2	0.6	1.1	1.8	1.8	1.8
Breast cancer (self-reported)	1.5	1.8	2.3	-1.5	-1.0	-1.3	-1.5	-1.3
Ever smoked	1.5	2.6	3.6	0.9	1.8	1.6	1.6	1.9
Impedance of whole body	1.5	7.7	8.7	3.0	2.8	2.6	2.7	2.8
Prostate Cancer	1.4	2.0	3.1	-0.8	-1.1	-1.7	-1.8	-1.6
Fasting Glucose	1.4	1.6	3.7	0.9	1.9	-0.0	1.1	1.6
Blood Platelet Count	1.4	15.9	18.0	-4.1	-3.6	-4.2	-3.8	-4.1
Serious illness, injury or assault to yourself	1.4	1.7	5.3	-2.3	-0.9	-1.1	-0.8	-0.7
Wheeze or whistling in the chest in last year	1.4	2.5	3.2	-1.0	-1.6	-1.8	-1.8	-1.7
Pulse wave peak to peak time	1.4	1.6	3.8	-2.0	-1.1	-0.9	-1.1	-1.1
Financial situation satisfaction	1.4	1.7	2.2	-1.4	-1.5	-1.2	-1.4	-1.0
Coronary Artery Disease (CAD)	1.3	1.5	3.5	-1.9	-1.1	-0.9	-1.2	-0.8
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.3	-0.1	1.2	1.5	1.5	1.5
Impedance of arm (right)	1.3	6.0	6.7	2.6	2.5	2.2	2.5	2.3
Time employed in main current job	1.3	1.6	2.6	0.0	1.2	1.5	1.2	1.6
Pulse wave Arterial Stiffness index	1.3	1.5	3.8	1.9	1.0	0.8	1.0	1.0
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	3.4	1.1	1.8	1.7	1.9	1.4
Worry too long after embarrassment	1.3	2.2	3.0	-1.7	-1.5	-1.2	-1.5	-1.4
Medication: Aspirin	1.3	1.8	5.3	-0.6	-2.3	-0.9	-1.4	-0.7
Ever depressed for a whole week	1.3	1.6	2.5	0.9	1.2	1.4	1.6	1.2
Schizophrenia vs Biploar Disorder	1.2	1.5	3.7	1.9	0.9	1.0	1.1	1.0
Ovarian Cancer	1.2	1.6	2.8	1.2	1.7	1.1	1.1	1.1
Commuting to job workplace: Car/motor vehicle	1.2	1.4	3.1	0.2	1.2	1.2	1.8	1.0
Supplements: Vitamin C	1.2	1.4	2.8	-0.7	1.1	1.1	1.7	1.2
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.2	-0.8	-1.5	-1.2	-1.5	-1.1
Impedance of leg (right)	1.1	5.4	6.8	2.4	2.3	2.4	1.9	2.6
Medication: Atenolol	1.1	1.3	2.0	0.9	0.7	1.2	1.4	1.3
Impedance of leg (left)	1.1	5.6	6.5	2.5	2.3	2.4	2.1	2.5
Fluid intelligence score	1.1	2.3	2.9	-1.6	-1.7	-1.5	-1.5	-1.4
Illnesses of siblings	1.1	1.6	2.8	-0.3	-0.7	-1.7	-1.6	-1.5
Hearing aid user	1.1	1.3	2.2	0.2	1.5	1.0	1.2	1.2
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.1	-1.4	-0.9	-1.3	-0.9	-1.2
Sensitivity / hurt feelings	1.0	1.7	2.9	-0.8	1.0	1.7	1.2	1.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	1.7	-1.0	-0.8	-1.0	-1.3	-1.0
Medication: Levothyroxine sodium	1.0	1.7	2.8	0.6	1.4	1.3	1.7	1.2
Past tobacco smoking	1.0	1.8	2.4	-0.6	-1.3	-1.4	-1.5	-1.5
Breastfed as a baby	1.0	1.2	2.7	-1.7	-0.6	-1.1	-0.8	-1.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.6	-1.2	-0.8	-1.5	-1.2	-1.6
Loneliness, isolation	1.0	1.3	2.3	0.3	1.3	1.5	0.9	1.3
Eye problems/disorders: Cataract	1.0	1.2	2.0	1.0	1.4	0.9	1.0	1.1
Number of treatments/medications taken	0.9	1.6	2.5	-0.1	1.1	1.4	1.6	1.5
Medication: Co-codamol	0.9	1.1	2.0	0.6	1.4	1.0	1.1	0.8
Relative age voice broke	0.9	1.4	2.1	-0.4	-1.2	-1.4	-1.2	-1.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	4.5	-2.1	-0.6	-0.5	-0.4	-0.5
Qualifications: CSEs or equivalent	0.9	1.2	1.9	1.2	1.4	0.6	1.4	0.7
Had other major operations	0.9	1.1	1.5	0.7	0.9	1.2	1.2	1.1
Pain all over the body in last month	0.9	1.0	1.2	0.7	1.1	1.1	1.0	1.1
Health satisfaction	0.9	1.2	1.7	0.9	1.1	1.3	0.7	1.3
Medication: Allopurinol	0.9	1.2	2.3	-0.2	0.9	1.5	1.1	1.3
Irritability	0.9	1.5	2.5	0.3	1.1	1.4	1.6	1.3
Alzheimer’s Disease (in father)	0.8	0.9	3.1	1.8	-0.2	-0.5	-0.8	-0.6
Primary Biliary Cirrhosis	0.8	1.2	1.5	1.1	0.7	1.1	1.2	1.2
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.5	-0.9	0.9	0.8	1.2	0.9
Smoking status: Previous	0.8	1.2	1.5	1.0	1.1	1.1	1.2	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.7	-0.5	-0.6	-1.3	-0.8	-1.2
Medication: Gliclazide	0.8	0.9	2.8	-1.7	-1.1	-0.5	-0.5	-0.4
Supplements: Calcium	0.8	0.9	2.8	-1.7	-1.1	-0.3	-0.3	-0.4
Major Depression (MDD)	0.7	0.9	1.7	1.3	1.1	0.6	0.7	0.8
Body Mass Index (BMI) (2010)	0.7	1.0	1.9	-1.4	-0.9	-0.8	-0.9	-0.9
Waist Hip Ratio (WHR)	0.7	3.4	4.4	2.1	-1.7	-1.7	-2.1	-1.5
Hypothyroidism (self reported)	0.7	1.7	2.7	0.6	1.6	1.4	1.6	1.1
Trunk fat percentage	0.7	2.6	4.2	0.1	2.1	1.6	1.9	1.6
Had menopause	0.7	0.8	1.4	-1.1	0.5	0.7	1.2	0.8
Falls in the last year	0.7	0.9	1.9	-0.2	-1.4	-1.0	-0.6	-1.1
Number of live births	0.7	1.0	1.8	-0.5	1.3	0.8	1.4	0.8
Happiness	0.7	0.8	2.0	1.0	-0.7	-0.4	-1.4	-0.6
Noisy workplace	0.7	0.8	1.2	1.1	1.0	0.9	0.7	0.7
Body fat percentage	0.7	2.7	4.5	0.1	2.1	1.7	1.8	1.7
Medication: Blood pressure	0.7	1.2	2.1	0.7	0.6	1.5	0.9	1.5
Overall health rating	0.7	1.4	2.1	0.5	1.1	1.5	1.2	1.4
Family relationship satisfaction	0.7	0.8	1.8	-0.5	-0.8	-0.9	-1.3	-0.9
Alcohol drinker status: Never	0.7	0.8	2.6	-1.6	-1.1	-0.2	-0.3	-0.3
Number of operations (self-reported)	0.7	1.0	1.6	0.2	1.3	1.0	1.0	1.1
Depressed Affect (Nagel 2018)	0.6	1.2	1.9	-0.6	1.4	1.1	1.2	1.1
Worry (Nagel 2018)	0.6	1.3	1.7	0.8	1.2	1.3	1.1	1.3
Diabetes (mother)	0.6	0.7	1.7	-0.0	-0.5	-0.9	-1.3	-0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.3	0.6	0.9	1.1	0.7	0.9
Diabetes (self-reported)	0.6	0.9	1.5	1.2	0.8	0.9	0.8	1.1
Illnesses of mother	0.6	0.8	2.0	1.4	-0.4	-0.4	-1.1	-0.4
Pulse wave reflection index	0.6	0.8	1.6	1.3	0.8	0.4	1.1	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.1	0.5	0.8	0.9	0.8	1.1
Qualifications: College or University degree	0.6	1.9	2.8	-0.8	-1.7	-1.3	-1.5	-1.4
Mood swings	0.6	1.0	1.7	0.1	1.2	0.9	1.3	1.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.9	-0.2	-1.1	-1.0	-1.4	-0.9
Mineral and other dietary supplements	0.6	0.8	1.4	-0.0	1.2	0.9	1.1	0.7
Osteoporosis (self-reported)	0.6	0.7	1.4	0.1	0.8	1.2	1.0	0.7
Average weekly champagne plus white wine intake	0.6	0.9	2.5	0.0	0.7	0.8	1.6	0.8
Ever taken oral contraceptive pill	0.6	0.7	1.5	0.1	1.1	0.7	1.2	0.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	3.4	-1.8	-0.4	0.0	0.1	-0.2
Neuroticism (Nagel 2018)	0.5	1.1	1.6	-0.8	0.8	1.2	1.2	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.9	-2.0	-1.0	-0.7	-0.8	-0.5
LDL Cholesterol	0.5	0.8	1.2	0.6	0.7	1.1	1.0	1.0
Lung FEV1/FVC ratio	0.5	2.4	3.2	-0.2	1.8	1.7	1.7	1.8
Neuroticism	0.5	1.2	1.7	0.1	1.1	1.3	1.2	1.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.1	-0.1	1.0	0.6	0.6	1.0
Systolic blood pressure, automated reading	0.5	1.5	2.5	0.9	0.9	1.6	1.0	1.6
High blood pressure (mother)	0.5	0.7	2.4	-1.6	-0.5	-0.6	-0.0	-0.6
Neuroticism score	0.5	1.1	1.7	-0.1	0.9	1.3	1.1	1.2
Arm fat percentage (right)	0.5	2.1	4.1	-0.2	2.0	1.4	1.6	1.3
Alcohol intake versus 10 years previously	0.5	0.7	1.0	0.5	0.8	1.0	0.8	1.0
Depression (self-reported)	0.5	0.6	0.9	-0.6	0.8	0.7	1.0	0.7
Tense / ‘highly strung’	0.5	0.8	1.2	0.3	0.8	1.1	0.8	1.1
Blood clot in the leg (DVT)	0.5	0.6	2.8	-1.7	-0.5	-0.0	0.1	-0.2
Medication: Paracetamol	0.5	0.7	2.0	0.2	1.1	0.5	1.4	0.5
Glaucoma (self-reported)	0.5	0.6	1.4	-1.2	-0.8	-0.5	-0.4	-0.5
Leg fat percentage (right)	0.5	1.7	3.1	-0.4	1.8	1.3	1.2	1.4
Exposure to tobacco smoke outside home	0.5	0.7	1.8	1.4	-0.2	-0.4	-1.1	-0.4
Number of full sisters	0.5	0.6	1.0	-0.9	-1.0	-0.8	0.0	-0.7
Illnesses of father: Heart disease	0.5	0.7	2.3	-1.5	-0.5	-0.6	-0.3	-0.6
Arm fat percentage (left)	0.5	1.9	3.7	-0.2	1.9	1.3	1.5	1.3
Back pain experienced in last month	0.5	0.7	3.3	-1.8	-0.3	-0.3	0.2	-0.4
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.8	-1.7	-0.2	-0.2	0.5	-0.2
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	-0.4	0.9	0.6	1.0	0.5
Neuroticism (2016)	0.4	0.6	1.3	-0.2	0.7	0.8	0.7	1.1
Blood Red Count	0.4	4.1	4.9	1.5	1.9	2.2	2.2	2.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.1	0.2	1.0	0.5	0.9	0.5
Medication for hormone replacement therapy	0.4	0.5	1.9	-1.4	-0.1	-0.3	0.4	-0.2
Medication: Metformin	0.4	0.6	1.3	-0.1	0.6	0.8	1.1	0.9
Fed-up feelings	0.4	0.7	1.1	-0.6	1.1	0.9	0.7	0.9
Multivitamins +/- minerals	0.4	0.5	1.0	0.4	1.0	0.4	0.9	0.5
Trunk fat mass	0.4	1.7	2.9	-0.2	1.7	1.3	1.5	1.3
Alcohol usually taken with meals	0.4	0.6	1.2	-1.1	-1.0	-0.2	-0.9	-0.4
Length of working week for main job	0.4	0.4	0.9	-0.9	-0.8	-0.5	0.0	-0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.6	0.4	-1.3	-0.1	-0.6	-0.6
Age at first live birth	0.4	0.6	0.9	0.3	-0.6	-1.0	-0.9	-0.9
Age at last live birth	0.4	0.6	1.3	0.1	-0.5	-0.8	-1.1	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	-1.2	-0.7	-0.4	-0.5	-0.5
Asthma (self-reported)	0.4	0.8	2.9	-1.7	-0.5	-0.6	-0.0	-0.7
Mother’s age at death	0.4	0.5	1.2	-0.6	-0.3	-1.1	-0.1	-0.8
Leg fat percentage (left)	0.4	1.3	2.5	-0.5	1.6	1.1	1.1	1.1
Commuting to job workplace: Cycle	0.4	0.4	0.9	-0.2	-0.5	-0.6	-1.0	-0.7
Pack years of smoking	0.4	0.6	1.4	-0.5	0.2	1.2	0.5	1.1
Arm predicted mass (left)	0.4	2.1	2.5	-1.4	-1.4	-1.4	-1.3	-1.6
Bipolar Disorder (2011)	0.3	0.3	0.8	0.9	0.3	0.2	0.6	0.0
Allergy or Eczema	0.3	0.7	3.2	-1.8	-0.2	-0.0	0.7	-0.1
Hair Pigment	0.3	7.6	10.0	0.8	2.8	3.0	3.1	3.2
Average weekly spirits intake	0.3	0.3	0.7	-0.8	-0.2	-0.5	-0.7	-0.5
Severe depression (siblings)	0.3	0.3	0.6	-0.4	-0.2	0.8	0.6	0.8
Pack years adult smoking proportion	0.3	0.4	1.0	-0.4	0.0	1.0	0.4	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.7	-1.3	-0.3	-0.2	-0.6	-0.2
Mouth/teeth dental problems	0.3	0.4	0.7	-0.7	-0.1	-0.8	-0.6	-0.6
Allergy	0.3	0.6	1.6	1.3	-0.4	-0.4	-1.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	-1.1	-0.5	-0.5	-0.1	-0.4
Trunk fat-free mass	0.3	1.9	2.7	-1.6	-1.3	-1.3	-1.3	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	2.0	-1.4	-0.2	-0.0	-0.2	-0.1
Asthma	0.3	0.7	2.6	-1.6	-0.4	-0.5	0.2	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.8	-0.9	-0.1	-0.6	-0.1	-0.7
Trunk predicted mass	0.3	1.9	2.5	-1.6	-1.3	-1.3	-1.2	-1.5
Exposure to tobacco smoke at home	0.3	0.4	0.6	0.4	0.5	0.7	0.5	0.8
Birth weight of first child	0.3	0.6	1.1	-0.7	-0.5	-0.8	-0.5	-1.0
Loud music exposure frequency	0.3	0.4	0.5	-0.7	-0.7	-0.4	-0.5	-0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.5	-1.2	0.3	-0.3	0.4	-0.5
Birth weight	0.3	0.6	1.2	-1.1	-0.5	-1.0	-0.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.2	1.1	0.3	0.0	0.4	0.1
Shortness of breath walking on level ground	0.3	0.4	1.4	-0.3	-0.3	-0.6	-1.2	-0.4
Migraine (self-reported)	0.3	0.3	0.6	0.2	0.5	0.7	0.4	0.8
Medication: Seretide 50 evohaler	0.3	0.3	1.3	-1.1	-0.5	0.0	0.3	-0.1
Alcohol intake frequency.	0.3	0.7	2.8	-1.7	-0.7	0.0	-0.3	-0.2
Comparative height size at age 10	0.3	1.8	2.4	1.1	1.4	1.5	1.2	1.6
Had major operations	0.3	0.4	1.5	-1.2	0.2	0.1	0.6	0.0
Whole body fat-free mass	0.3	1.7	2.2	-1.5	-1.2	-1.2	-1.1	-1.4
Diabetes diagnosed by doctor	0.3	0.6	1.1	0.6	0.6	0.8	0.7	1.1
Whole body water mass	0.3	1.6	2.0	-1.4	-1.2	-1.2	-1.1	-1.4
Medication: Lisinopril	0.3	0.4	0.8	-0.9	-0.3	-0.4	-0.8	-0.7
Medication: Atorvastatin	0.3	0.3	1.2	-0.5	-1.1	-0.2	-0.1	-0.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.3	-1.2	-0.1	0.3	0.7	0.2
Heart disease (siblings)	0.3	0.3	0.8	-0.3	0.3	0.9	0.4	0.7
Mean Putamen Volume	0.2	0.3	0.4	-0.5	0.6	0.5	0.4	0.6
HbA1C	0.2	0.3	0.5	0.2	0.6	-0.7	-0.6	0.2
Respiratory disease	0.2	0.5	2.4	-1.6	-0.3	-0.3	0.3	-0.2
Hand grip strength (left)	0.2	0.4	0.9	-0.4	0.6	0.7	1.0	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.2	-1.1	0.5	-0.0	0.5	-0.0
Supplements: Zinc	0.2	0.2	0.6	-0.1	-0.8	-0.5	-0.1	-0.6
Leg fat-free mass (left)	0.2	0.9	1.9	-1.4	-0.7	-0.9	-0.5	-1.0
Hand grip strength (right)	0.2	0.6	1.1	-0.5	0.7	0.7	1.1	0.6
Townsend deprivation index at recruitment	0.2	0.3	1.0	1.0	0.1	0.4	0.1	0.5
Age when periods started (menarche)	0.2	0.5	1.8	1.4	-0.1	0.4	0.3	0.6
High blood pressure	0.2	0.5	0.7	0.4	0.6	0.8	0.6	0.9
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.1	-1.4	-0.2	-0.2	0.4	-0.1
Supplements: Glucosamine	0.2	0.3	0.9	-0.9	0.4	0.2	0.6	0.4
Sitting height	0.2	1.8	2.5	-0.4	1.3	1.6	1.4	1.5
Leg predicted mass (left)	0.2	1.0	1.8	-1.4	-0.8	-0.9	-0.6	-1.1
Financial difficulties in last 2 years	0.2	0.3	1.3	1.1	0.2	0.4	0.2	0.2
Hip circumference	0.2	0.7	2.7	-1.6	0.3	0.4	0.6	0.3
Father’s age at death	0.2	0.2	0.7	0.5	-0.8	-0.0	0.2	-0.2
Pulse rate	0.2	0.4	1.1	0.9	1.1	0.1	-0.2	0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	-0.1	0.6	0.6	0.5	0.7
Medication: Cholesterol lowering	0.2	0.4	0.7	0.8	0.1	0.6	0.6	0.7
Medication: Lansoprazole	0.2	0.2	0.5	-0.3	0.5	0.3	0.5	0.7
Lung cancer (father)	0.2	0.2	0.9	-1.0	0.0	-0.2	0.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.7	-0.6	0.7	0.5	0.4	0.8
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	-0.8	0.6	0.6	0.6	0.4
Medication: Amlodipine	0.2	0.2	0.9	1.0	-0.1	0.0	-0.5	0.1
Arm fat-free mass (right)	0.2	0.9	1.3	-1.2	-0.9	-0.9	-0.8	-1.0
Number of full brothers	0.2	0.2	0.4	0.4	0.5	0.5	0.2	0.6
Number of children fathered	0.2	0.2	0.5	-0.7	-0.6	-0.2	-0.3	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	0.5	-0.3	-0.5	-1.0	-0.5
Heart disease (mother)	0.2	0.2	0.4	-0.3	0.4	0.5	0.6	0.4
Whole body fat mass	0.2	1.0	1.9	-0.3	1.4	1.0	1.1	0.9
Leg fat mass (right)	0.2	0.8	1.7	-0.5	1.3	0.9	0.8	0.9
Pulse rate, automated reading	0.2	0.6	1.0	-0.4	-0.4	-1.0	-1.0	-0.8
Chest pain or discomfort	0.2	0.2	0.7	-0.8	-0.5	-0.2	-0.4	-0.2
Hypertension (Self-reported)	0.2	0.6	1.0	0.3	0.7	0.9	0.7	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.6	-0.2	0.1	0.5	0.8	0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.5	-0.7	-0.3	0.5	0.5	0.3
Leg fat-free mass (right)	0.2	1.2	1.7	-1.3	-1.0	-1.1	-0.6	-1.3
Qualifications: nursing, teaching	0.2	0.4	0.6	0.0	0.8	0.6	0.6	0.7
Medication for cholesterol	0.2	0.4	0.6	-0.2	0.7	0.8	0.8	0.2
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.0	0.8	0.6	0.5	0.6
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.8	0.5	0.2	0.6	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.2	-0.0	0.5	0.3	1.1	0.1
Leg predicted mass (right)	0.2	1.1	1.6	-1.3	-0.9	-1.1	-0.6	-1.2
Miserableness	0.2	0.4	0.9	-0.2	0.9	0.7	0.4	0.7
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.2	-0.3	-0.6	-0.6	-0.5
Medication: Paracetamol	0.2	0.3	0.9	-0.9	0.2	-0.4	0.6	-0.4
Basal metabolic rate	0.2	1.1	2.1	-1.4	-0.8	-0.9	-0.7	-1.1
Arm fat-free mass (left)	0.2	1.3	1.6	-1.3	-1.0	-1.0	-1.0	-1.2
Diastolic blood pressure, automated reading	0.2	0.8	1.1	0.6	1.0	0.9	0.6	1.1
Unable to work because of sickness or disability	0.2	0.3	0.3	-0.4	0.4	0.6	0.6	0.5
Cholesterol lowering medication	0.2	0.2	0.6	0.6	-0.2	0.3	0.2	0.8
Basal cell carcinoma (self-reported)	0.2	0.3	0.9	1.0	0.1	0.3	0.5	0.2
Leg fat mass (left)	0.2	0.8	1.5	-0.5	1.2	0.8	0.9	0.8
Bipolar Disorder (2018)	0.1	0.2	0.8	0.9	0.0	-0.0	0.2	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.2	-1.1	-0.3	0.3	0.2	0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.5	0.5	0.7	0.2	0.2	0.1
Reaction Time	0.1	0.2	0.7	-0.8	-0.5	-0.3	-0.4	0.0
Breast Cancer	0.1	0.2	0.5	0.7	0.4	0.3	-0.1	0.2
HDL Cholesterol	0.1	0.1	0.4	-0.0	-0.4	0.2	-0.6	0.1
Lupus	0.1	0.1	0.3	0.5	0.3	0.0	0.3	-0.0
Triglycerides	0.1	0.2	0.3	0.5	0.6	-0.1	0.5	0.1
Blood Eosinophil Count	0.1	0.6	1.7	-1.3	-1.0	0.0	0.6	0.2
Blood White Count	0.1	0.9	2.5	0.2	0.2	1.2	1.6	0.7
Heel T-Score	0.1	0.8	1.8	-0.2	0.9	1.2	0.5	1.3
BMI	0.1	0.8	4.0	-2.0	-0.1	-0.2	-0.2	-0.3
Cardiovascular Disease	0.1	0.3	1.0	1.0	0.2	0.4	0.0	0.5
Lung FVC	0.1	0.3	0.8	0.6	-0.9	-0.3	-0.2	-0.5
Chronotype (morning person)	0.1	0.3	1.2	-1.1	-0.2	-0.2	-0.4	0.0
Tanning	0.1	0.6	1.7	-0.5	-1.3	-0.7	-0.4	-0.6
Current tobacco smoking	0.1	0.1	0.3	0.1	0.5	0.3	0.5	0.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.6	-0.4	-0.3	-0.1	-0.2
Body mass index (BMI)	0.1	0.6	2.6	-1.6	0.1	-0.2	-0.1	-0.3
Waist circumference	0.1	0.2	0.9	-0.9	-0.2	-0.2	-0.2	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	-0.2	0.7	0.4	0.4	0.3
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.5	-0.4	0.7	0.2	0.5
Forced vital capacity (FVC)	0.1	0.2	0.6	0.8	-0.3	-0.2	0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.9	-0.9	-0.0	-0.2	0.5	-0.0
Qualifications: None of the above	0.1	0.1	0.4	0.2	-0.5	-0.2	-0.6	0.0
Medication: Ramipril	0.1	0.1	0.2	-0.3	-0.2	-0.4	-0.4	-0.4
Weight	0.1	0.4	1.7	-1.3	0.2	-0.0	0.2	-0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.2	0.4	0.3	0.4	0.5
Arm fat mass (right)	0.1	0.4	0.8	-0.8	0.9	0.4	0.5	0.2
Gout (self-reported)	0.1	0.1	0.5	-0.7	-0.2	0.4	0.1	0.2
Forced vital capacity (FVC), Best measure	0.1	0.2	0.5	0.7	0.3	0.2	0.7	0.1
Neck or shoulder pain in last month	0.1	0.2	0.6	-0.8	-0.3	-0.0	0.0	-0.1
Medication: Ibuprofen	0.1	0.1	0.3	-0.4	0.4	0.0	0.5	-0.1
Medication: Omeprazole	0.1	0.1	0.2	-0.5	-0.4	-0.2	0.1	-0.1
Mean time to correctly identify matches	0.1	0.3	0.9	-0.9	0.1	0.3	-0.1	0.6
Arm predicted mass (right)	0.1	0.6	0.8	-0.9	-0.8	-0.7	-0.7	-0.8
Suffer from ‘nerves’	0.1	0.2	0.4	-0.3	0.2	0.6	0.7	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.5	0.7	0.3	0.4	0.2	0.3
Knee pain experienced in last month	0.1	0.2	0.4	-0.7	0.6	-0.1	0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.2	0.2	-0.4	-0.4	0.3	-0.3
Commuting to job workplace: Walk	0.1	0.1	0.2	0.1	-0.3	0.0	-0.5	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.4	-0.3	0.5	-0.4	0.2
Smoking status: Current	0.1	0.2	0.3	0.2	0.5	0.4	0.6	0.5
Arm fat mass (left)	0.1	0.4	1.0	-0.7	1.0	0.4	0.5	0.3
Guilty feelings	0.1	0.1	0.6	-0.8	0.0	-0.0	-0.1	-0.2
Medication: Blood pressure	0.1	0.1	0.2	0.3	-0.3	-0.4	-0.5	-0.1
Risk taking	0.1	0.2	0.3	0.6	-0.1	0.4	0.2	0.5
Age started oral contraceptive pill	0.1	0.1	0.2	0.1	-0.2	0.5	0.1	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.1	-0.3	-0.5	-0.4	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.3	-0.0	-0.4	0.1	-0.2
Pain experienced in last month	0.1	0.2	0.7	-0.1	-0.3	-0.4	-0.8	-0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.0	-0.3	0.5	0.1	0.4
Alcohol drinker status: Previous	0.1	0.1	0.4	0.6	0.5	0.1	-0.2	-0.1
Depression (Nagel 2018)	0.0	0.1	0.3	-0.5	0.2	-0.2	0.0	-0.1
Age at First Birth	0.0	0.1	0.1	0.3	0.4	0.1	-0.1	0.4
Rheumatoid Arthritis	0.0	0.0	0.1	-0.3	-0.1	0.1	0.3	0.1
Height	0.0	0.3	1.5	1.2	-0.2	-0.1	-0.1	-0.2
Systolic Blood Pressure	0.0	0.2	0.6	0.8	0.0	0.5	0.0	0.4
Smoking Status	0.0	0.0	0.0	-0.0	0.2	-0.1	0.1	0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	0.2	0.1	-0.0	0.1	0.1
Relative age of first facial hair	0.0	0.1	0.2	-0.4	-0.0	-0.4	0.2	-0.1
Diabetes (father)	0.0	0.0	0.1	0.0	-0.2	0.0	-0.3	0.1
Average weekly fortified wine intake	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.3	-0.4	0.1	0.1	0.5	0.3
Stomach or abdominal pain in last month	0.0	0.0	0.1	0.0	-0.0	-0.1	0.3	0.0
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	-0.2	-0.2	-0.0	-0.2	-0.2
Number of incorrect matches in round	0.0	0.0	0.1	0.1	0.2	-0.2	0.3	0.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.0	-0.1
Heart attack	0.0	0.1	0.2	0.1	-0.4	0.3	-0.0	0.2
Worrier / anxious feelings	0.0	0.0	0.1	-0.4	-0.2	0.0	0.1	0.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.3	0.2	-0.1	-0.2	0.2	-0.5
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	-0.5	-0.2	0.0	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	0.3	0.1	-0.2	0.5	-0.3
Standing height	0.0	0.2	0.3	0.5	0.3	0.4	0.5	0.3
Peak expiratory flow (PEF)	0.0	0.1	0.2	-0.5	-0.1	0.1	0.3	-0.1
Ever highly irritable/argumentative for 2 days	0.0	0.1	0.1	0.3	0.1	-0.2	0.0	-0.4
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.2	-0.5	0.4	0.2	-0.0	-0.1
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.1	-0.1	-0.3	-0.1	-0.3	0.0
Comparative body size at age 10	0.0	0.1	0.4	-0.6	0.3	-0.3	-0.1	-0.2
Eye problems/disorders: None of the above	0.0	0.1	0.2	0.4	-0.0	-0.2	0.0	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.3	-0.0	0.1	0.1	0.5	-0.0
Average weekly red wine intake	0.0	0.0	0.0	0.1	0.1	0.2	0.2	0.2
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	-0.1	0.3	-0.0	0.2	-0.0
Eye problems/disorders: Glaucoma	0.0	0.1	0.2	-0.5	-0.1	-0.2	0.1	-0.2
Medication: Bendroflumethiazide	0.0	0.1	0.2	-0.5	0.2	-0.2	-0.0	-0.2
Average weekly beer plus cider intake	0.0	0.0	0.1	0.0	0.2	-0.1	-0.2	-0.0

Hub : Genes

ITLN1

Models

Trait associations