Hub : Genes

NRIP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0800	0.0280	1.5e-03	0.030	0.008	-0.001	0.011	0.010	1.4e-04	2.8e-02	4.2e-01	1.6e-02	1.7e-02
2	YFS	Blood	0.0363	0.0102	8.8e-06	0.017	0.015	0.019	0.015	0.020	1.9e-06	5.6e-06	5.0e-07	7.7e-06	2.8e-07
3	TCGA	Prostate Adenocarcinoma	0.0919	0.0335	3.2e-05	0.090	0.061	0.076	NA	0.082	1.3e-09	5.3e-07	2.4e-08	NA	6.0e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.0	0.0	0.0	-0.1	-0.0	-0.0
Bipolar Disorder or Schizophrenia	0.9	2.2	6.4	-0.0	0.3	2.5
Depressed Affect (Nagel 2018)	0.3	0.6	1.0	-1.0	-0.7	-0.6
Depression (Nagel 2018)	0.7	1.1	1.9	-1.0	-1.4	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	-0.7	-0.6	-0.3
Neuroticism (Nagel 2018)	1.6	3.8	6.2	-2.5	-2.2	-0.5
Schizophrenia (2018)	1.8	3.6	10.8	0.1	0.4	3.3
Schizophrenia vs Biploar Disorder	2.0	2.6	4.8	0.3	-1.7	2.2
Worry (Nagel 2018)	2.3	4.9	11.9	-1.6	-3.5	-0.5
Alzheimer’s Disease (in mother)	1.0	1.2	2.5	1.0	0.1	1.6
Alzheimer’s Disease (in father)	0.7	0.7	2.0	-1.4	-0.2	0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	1.6	-0.0	-0.5	1.3
Crohns Disease (2017)	5.1	11.1	32.4	-5.7	-1.0	-0.1
Irritable Bowel Disease (IBD)	5.2	12.5	36.6	-6.0	-0.8	-0.3
Ulcerative Colitis (UC)	3.1	5.9	17.3	-4.2	-0.5	-0.4
Major Depression (MDD)	2.4	2.9	3.6	-1.4	-1.8	-1.9
Reaction Time	0.6	1.1	2.7	1.6	-0.0	0.9
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.1	-0.1	0.7
Breast Cancer	0.1	0.2	0.3	-0.4	-0.3	-0.6
Ovarian Cancer	1.0	1.3	3.1	0.2	1.8	-0.9
Prostate Cancer	0.1	0.1	0.1	0.4	0.1	-0.2
Age at First Birth	1.3	1.9	3.6	1.9	0.7	1.3
Bipolar Disorder (2011)	0.7	0.7	1.9	-1.4	0.3	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	-0.5	0.3	-0.7
Coronary Artery Disease (CAD)	2.2	2.7	7.1	-0.6	-2.7	0.7
Crohns Disease (2012)	3.3	5.3	15.4	-3.9	-0.4	-0.6
Mean Putamen Volume	0.1	0.1	0.3	-0.2	0.6	0.1
Fasting Glucose	1.8	2.1	6.1	0.3	-2.5	-0.4
HbA1C	0.5	0.6	1.1	-0.7	-1.0	0.3
HDL Cholesterol	1.9	3.2	8.4	1.0	0.4	2.9
LDL Cholesterol	1.3	2.0	4.8	-1.0	-0.5	-2.2
Lupus	1.2	1.8	3.5	-0.1	-1.9	1.4
Neuroticism (2016)	0.9	1.3	3.4	-0.7	-1.9	0.1
Primary Biliary Cirrhosis	0.4	0.5	0.9	1.0	0.5	0.6
Rheumatoid Arthritis	1.7	2.3	5.0	-1.1	0.8	2.2
Schizophrenia (2014)	0.8	1.7	4.8	-0.3	-0.5	2.2
Triglycerides	1.2	2.0	2.8	-1.7	-1.1	-1.3
Type 2 Diabetes (T2D) (2012)	1.4	1.6	3.9	-0.6	-2.0	-0.7
Ulcerative Colitis	2.2	3.2	6.0	-2.5	-1.5	-1.1
Blood Eosinophil Count	0.6	4.7	12.5	-3.5	-1.2	0.6
Blood Platelet Count	1.2	14.3	33.5	1.4	2.7	5.8
Blood Red Count	0.6	6.0	14.1	-3.8	1.5	-1.3
Blood White Count	1.4	10.6	26.9	1.5	1.6	5.2
Heel T-Score	0.1	0.9	1.3	0.5	1.1	1.1
BMI	0.4	2.0	3.9	0.7	2.0	-1.3
Height	0.1	1.8	2.6	1.6	-1.5	-0.7
Waist Hip Ratio (WHR)	0.1	0.2	0.7	-0.2	-0.1	-0.8
Systolic Blood Pressure	0.3	1.3	2.4	1.1	-0.6	1.6
Smoking Status	0.3	0.6	1.6	-0.3	-0.5	-1.2
Allergy or Eczema	1.0	2.5	6.4	-2.5	-1.1	0.0
Cardiovascular Disease	0.7	2.3	4.5	0.8	-2.1	1.3
Hypothyroidism (self reported)	3.0	6.9	18.0	-4.2	0.7	-1.5
Respiratory disease	0.5	1.1	2.3	-1.0	-1.5	-0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.4	-0.6	0.4	-0.4
Lung FEV1/FVC ratio	0.2	1.2	2.3	1.0	1.5	-0.6
Lung FVC	0.6	2.9	8.4	0.6	-2.9	-0.3
Neuroticism	1.2	2.9	5.4	-1.6	-2.3	-0.8
Chronotype (morning person)	0.4	0.9	1.8	-1.4	0.2	-0.8
Hair Pigment	0.1	2.3	4.3	-2.1	-1.1	1.1
Tanning	0.0	0.1	0.3	-0.1	-0.4	0.5
Hand grip strength (left)	0.7	1.9	2.4	-1.4	-1.5	-1.1
Number of treatments/medications taken	1.2	2.2	4.5	-2.1	-1.1	-1.0
Average weekly spirits intake	3.2	3.9	6.4	-0.7	-2.5	-2.2
Sensitivity / hurt feelings	1.2	2.0	4.8	-2.2	-0.7	-0.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.5	-0.6	-1.6	0.4
Hearing difficulty/problems: Yes	1.0	1.5	2.5	0.4	-1.4	1.6
Relative age of first facial hair	1.2	2.4	4.0	0.2	1.8	-2.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.1	-1.0	0.6	-1.0
Ever used hormone-replacement therapy (HRT)	1.4	1.8	2.5	1.6	-0.6	1.6
Ever had hysterectomy (womb removed)	0.5	0.6	1.2	0.7	0.4	1.1
Systolic blood pressure, automated reading	0.1	0.3	0.8	0.9	-0.1	-0.1
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.5	-1.9	-0.6	-1.4
Angina	0.5	0.7	1.3	-1.1	-0.8	-0.2
Medication for hormone replacement therapy	2.1	2.3	2.8	1.5	1.7	1.4
Vitamin and mineral supplements	0.4	0.5	1.3	0.5	-0.2	1.1
Supplements: Zinc	0.5	0.5	1.4	-0.4	0.2	1.2
Medication: Co-codamol	0.5	0.6	0.9	-0.4	-1.0	-0.8
Medication: Metformin	0.6	0.9	2.7	-0.1	-0.1	-1.6
Diabetes (father)	0.7	0.9	2.5	-1.6	0.1	-0.3
Diabetes (mother)	0.5	0.7	1.0	0.5	-1.0	-0.8
Severe depression (siblings)	0.1	0.1	0.3	0.1	0.5	0.1
Pack years adult smoking proportion	0.8	1.2	2.8	-1.7	-0.8	0.3
Impedance of leg (right)	0.1	0.3	0.6	0.3	0.8	0.5
Leg fat-free mass (left)	0.0	0.2	0.3	0.6	0.3	-0.4
Trunk fat percentage	0.8	3.3	9.6	0.3	3.1	-0.3
Hand grip strength (right)	0.7	1.8	3.5	-1.4	-1.9	0.2
Townsend deprivation index at recruitment	0.7	1.0	1.3	0.8	1.1	1.2
Current tobacco smoking	0.6	0.9	2.3	-0.6	0.2	-1.5
Average weekly fortified wine intake	0.1	0.2	0.2	0.5	-0.4	-0.2
Maternal smoking around birth	0.0	0.1	0.1	0.4	0.1	-0.1
Fed-up feelings	0.1	0.1	0.2	-0.4	0.5	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.6	0.3	0.4	1.3
Relative age voice broke	0.5	0.8	1.8	0.4	0.7	-1.3
Taking other prescription medications	2.9	4.5	12.1	-3.5	-1.1	-0.5
Age when periods started (menarche)	0.2	0.6	1.7	0.1	1.3	0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.1	-0.7	0.1	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.9	-1.4	-1.0	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.1	-0.1	-0.5
Qualifications: CSEs or equivalent	0.3	0.5	1.4	-0.0	1.2	-0.1
Serious illness, injury or assault to yourself	1.1	1.3	2.4	1.5	-1.1	0.5
High blood pressure	0.1	0.2	0.4	0.5	-0.2	0.6
Hayfever, allergic rhinitis or eczema	1.1	2.4	6.3	-2.5	-0.9	-0.5
Multivitamins +/- minerals	0.4	0.5	0.8	0.9	0.5	0.6
Stomach or abdominal pain in last month	0.2	0.2	0.6	-0.3	-0.8	-0.0
Supplements: Glucosamine	1.0	1.3	3.6	1.9	0.5	-0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	0.8	-0.2	1.1
Medication: Atenolol	3.6	4.5	7.4	-2.7	-0.5	-2.4
Medication: Levothyroxine sodium	2.9	4.8	12.7	-3.6	-0.2	-1.3
Sitting height	0.1	0.8	1.7	1.3	-0.7	0.3
Chronic bronchitis/emphysema (father)	0.7	0.9	1.8	0.3	0.8	-1.3
High blood pressure (mother)	1.3	1.8	2.6	1.4	1.6	1.0
Body mass index (BMI)	0.6	2.6	6.9	-0.0	2.6	-0.9
Impedance of leg (left)	0.1	0.4	0.9	0.1	0.9	0.4
Leg predicted mass (left)	0.0	0.2	0.3	0.6	0.2	-0.4
Trunk fat mass	0.6	2.4	6.8	0.4	2.6	-0.3
Waist circumference	0.6	2.2	6.2	0.0	2.5	-0.6
Number of incorrect matches in round	0.2	0.3	0.7	0.8	-0.4	-0.2
Past tobacco smoking	0.6	1.1	2.4	-0.8	-0.4	1.6
Alcohol usually taken with meals	0.6	1.0	1.3	-0.9	0.9	1.1
Nervous feelings	1.6	3.0	6.3	-1.3	-2.5	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.8	-0.3	-0.9	0.6
Hearing difficulty/problems with background noise	0.2	0.3	0.4	0.1	-0.6	-0.6
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	-0.6	-1.0	0.0
Had menopause	0.1	0.2	0.5	0.7	-0.1	-0.1
Had other major operations	2.1	2.5	5.2	-0.8	-2.3	1.3
Forced vital capacity (FVC)	1.4	5.5	15.6	0.9	-3.9	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	-0.6	-0.2	0.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.7	0.6	-0.6	-0.8
Qualifications: None of the above	0.6	1.3	2.3	-1.2	1.5	0.4
Financial difficulties in last 2 years	0.3	0.3	0.7	0.4	0.4	0.8
Mouth/teeth dental problems	1.0	1.5	4.4	0.1	2.1	-0.4
Heart attack	1.5	1.9	4.5	-2.1	-0.7	-0.7
Allergy	2.4	5.4	10.5	3.2	2.1	1.2
Pain all over the body in last month	0.6	0.6	1.7	0.1	1.3	-0.2
Diabetes (self-reported)	0.4	0.6	1.4	-0.4	0.5	-1.2
Hayfever/allergic rhinitis (self-reported)	3.3	4.3	7.7	-2.8	-1.4	-1.8
Medication: Ramipril	0.5	0.6	1.3	0.7	0.3	1.1
Medication: Simvastatin	1.0	1.5	2.1	-1.1	-1.0	-1.5
Fluid intelligence score	0.3	0.6	1.5	1.2	0.1	0.5
Illnesses of siblings	0.2	0.2	0.5	0.7	0.4	-0.2
Neuroticism score	1.0	2.2	4.3	-1.3	-2.1	-0.7
Weight	0.3	1.5	3.9	0.5	2.0	-0.7
Impedance of arm (right)	0.1	0.5	1.1	0.4	0.4	1.0
Arm fat percentage (right)	0.8	3.1	9.2	0.1	3.0	-0.2
Trunk fat-free mass	0.1	0.5	1.3	0.2	-1.2	-0.4
Hip circumference	0.8	3.2	9.2	0.6	3.0	-0.3
Time employed in main current job	0.9	1.0	2.8	-0.2	0.3	1.7
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.1	-0.1	-0.1
Father’s age at death	0.4	0.5	1.1	0.2	1.1	0.6
Worrier / anxious feelings	1.0	1.9	3.5	-1.4	-1.9	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.2	0.5	-0.3
Falls in the last year	0.9	1.2	1.8	1.2	1.4	-0.4
Hair/balding pattern: Pattern 3	1.0	1.4	3.2	0.9	1.8	-0.5
Number of live births	0.8	1.1	1.9	1.0	0.7	1.4
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	8.9	1.0	-3.0	-0.7
Pulse rate	1.3	2.3	6.4	-2.5	0.2	0.6
Happiness	0.3	0.4	0.7	0.9	0.5	0.4
Noisy workplace	2.1	2.6	4.1	-0.4	-1.9	-2.0
Qualifications: A levels/AS levels or equivalent	1.8	4.0	8.0	2.8	0.2	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	1.3	0.8	0.2
Mouth/teeth dental problems: Dentures	0.8	1.3	2.3	-1.2	-1.5	-0.4
Asthma	1.4	2.7	5.7	-1.4	-2.4	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.2	0.5	1.1	0.6
Medication: Cholesterol lowering	1.9	3.0	5.9	-1.7	-2.4	0.3
Depression (self-reported)	0.1	0.1	0.2	-0.3	-0.4	-0.2
Medication: Lansoprazole	0.9	1.1	1.4	-1.2	-1.1	-0.8
Prospective memory result	0.6	0.7	1.1	-1.0	0.4	-1.0
Lung cancer (father)	0.0	0.0	0.1	0.3	0.1	0.3
Illnesses of mother	1.0	1.2	2.5	-1.1	0.1	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	7.8	0.8	-2.8	0.0
Pulse wave Arterial Stiffness index	1.4	1.6	3.1	-1.8	0.7	-1.1
Impedance of arm (left)	0.1	0.7	1.4	0.6	1.2	0.6
Arm fat mass (right)	0.7	2.9	8.5	0.3	2.9	-0.4
Trunk predicted mass	0.1	0.6	1.5	0.3	-1.2	-0.4
Standing height	0.1	0.9	1.6	1.0	-1.3	-0.1
Length of working week for main job	1.2	1.3	3.8	1.9	0.2	-0.1
Exposure to tobacco smoke at home	1.1	1.2	2.5	1.0	-0.1	1.6
Breastfed as a baby	0.3	0.4	1.0	0.5	-0.3	1.0
Tense / ‘highly strung’	0.8	1.4	2.8	1.1	-1.7	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	3.8	-1.2	-1.8	2.0
Hair/balding pattern: Pattern 4	0.6	1.4	4.0	-2.0	-0.3	-0.2
Birth weight of first child	2.1	3.8	7.5	-2.0	-0.2	-2.7
Peak expiratory flow (PEF)	1.6	3.7	10.4	0.8	-3.2	-0.0
Pulse wave reflection index	0.2	0.2	0.7	0.0	-0.0	-0.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.3	-0.1	-0.7
Loud music exposure frequency	0.7	0.7	2.1	0.0	-1.5	0.1
Qualifications: O levels/GCSEs or equivalent	2.5	3.9	4.4	2.1	2.1	1.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.7	-0.4	-0.3	0.8
Blood clot in the leg (DVT)	0.8	1.0	1.8	1.4	0.4	1.1
Medication: Paracetamol	1.4	2.3	3.9	1.7	2.0	0.3
Headache pain in last month	0.3	0.6	1.1	-0.1	-1.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.7	1.6	1.2	0.1
Glaucoma (self-reported)	0.1	0.1	0.2	0.2	0.2	-0.4
Gout (self-reported)	0.0	0.0	0.1	-0.3	-0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	3.8	7.4	17.0	-4.1	0.7	-2.2
Medication: Amlodipine	0.4	0.5	1.2	0.6	-1.1	-0.2
Medication: Ventolin 100micrograms inhaler	2.1	2.7	5.8	-1.5	-2.4	0.0
Birth weight	0.9	1.9	3.2	-1.4	-0.7	-1.8
Chronic bronchitis/emphysema (mother)	1.2	1.3	4.0	-0.2	0.1	2.0
High blood pressure (siblings)	0.7	1.0	2.9	-0.2	-0.0	1.7
Forced vital capacity (FVC), Best measure	1.3	4.7	13.3	0.7	-3.6	0.7
Body fat percentage	1.0	3.9	11.5	0.4	3.4	-0.2
Leg fat percentage (right)	0.8	3.0	8.9	-0.1	3.0	-0.5
Arm fat-free mass (right)	0.1	0.4	0.5	0.6	-0.6	-0.7
Exposure to tobacco smoke outside home	0.8	1.0	1.3	1.1	1.1	0.8
Comparative body size at age 10	0.9	2.5	4.7	0.4	2.2	-1.6
Number of full brothers	0.5	0.6	0.8	0.8	-0.9	0.5
Worry too long after embarrassment	1.6	2.7	6.6	-2.6	-1.0	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.3	0.2	-0.1
Wheeze or whistling in the chest in last year	1.4	2.4	4.6	-2.2	-0.9	-1.3
Number of children fathered	0.8	1.0	2.5	0.5	1.6	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.1	0.3	1.5	-0.7
Age at first live birth	0.8	1.5	4.1	-0.4	-2.0	-0.4
Pulse wave peak to peak time	1.5	1.8	3.3	1.8	-0.9	1.1
Health satisfaction	0.3	0.4	1.0	0.1	-0.5	1.0
Shortness of breath walking on level ground	0.1	0.1	0.4	0.2	-0.6	-0.0
Qualifications: College or University degree	0.1	0.3	0.6	-0.7	0.1	0.8
Eye problems/disorders: None of the above	1.7	2.0	4.4	2.1	0.1	1.2
Mouth/teeth dental problems: Loose teeth	3.9	4.7	13.2	-0.8	0.3	-3.6
Emphysema/chronic bronchitis	2.4	2.7	6.1	0.4	-2.5	-1.4
Medication for pain relief, constipation, heartburn	0.9	1.5	2.5	-1.1	-1.6	-0.9
Neck or shoulder pain in last month	0.5	0.7	1.7	-1.3	-0.6	-0.1
Medication: Blood pressure	0.4	0.8	1.7	-1.3	-0.7	-0.3
Angina (self-reported)	0.7	1.0	2.1	-1.4	-0.9	-0.3
Migraine (self-reported)	2.6	3.2	4.6	2.0	2.1	1.1
Medication: Ibuprofen	0.2	0.3	0.5	0.7	0.4	0.3
Medication: Allopurinol	0.1	0.2	0.3	-0.1	0.5	0.6
Medication: Omeprazole	0.2	0.2	0.5	0.0	0.3	0.7
Medication: Seretide 50 evohaler	1.4	1.6	3.6	0.6	-1.9	-0.9
Mean time to correctly identify matches	0.5	0.9	1.6	1.3	0.2	1.0
Heart disease (mother)	0.4	0.5	0.8	-0.3	-0.9	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.6	-1.6	1.2	-0.5
Whole body fat mass	0.7	2.8	8.0	0.2	2.8	-0.7
Leg fat mass (right)	0.7	2.7	7.3	0.2	2.7	-0.9
Arm predicted mass (right)	0.1	0.4	0.7	0.7	-0.3	-0.8
Pulse rate, automated reading	0.1	0.3	0.6	0.4	0.8	0.4
Alcohol intake frequency.	0.2	0.5	1.1	-0.3	0.6	-1.0
Comparative height size at age 10	0.2	1.2	3.0	0.8	-1.7	0.4
Number of full sisters	0.8	1.0	2.7	1.6	0.6	-0.0
Suffer from ‘nerves’	2.4	3.8	11.0	-0.2	-3.3	0.6
Overall health rating	0.4	0.9	1.9	-0.2	0.9	1.4
Chest pain or discomfort	0.7	0.9	1.9	-1.4	-0.3	-0.9
Had major operations	0.7	0.9	1.5	-1.2	0.8	-0.7
Age at last live birth	0.2	0.2	0.4	-0.2	-0.6	-0.6
Family relationship satisfaction	1.1	1.3	1.8	1.4	-1.2	0.8
Leg pain on walking	0.7	0.9	2.5	-0.3	-0.4	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	0.9	0.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.2	-1.1	0.4	0.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.9	-1.4	-0.1	0.2
Medication: Aspirin	0.6	0.8	1.2	-0.5	-1.1	-1.0
Supplements: Vitamin C	0.0	0.0	0.1	-0.1	0.3	0.0
Knee pain experienced in last month	0.2	0.3	0.9	-0.0	0.2	0.9
Hypertension (Self-reported)	0.1	0.4	0.7	0.6	0.3	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.6	-0.9	-1.4	-1.9
Illnesses of father: Heart disease	1.8	2.5	3.1	-1.6	-1.8	1.3
Illnesses of siblings: Diabetes	2.7	3.3	7.2	-1.6	-0.5	-2.7
Smoking status: Previous	0.3	0.5	1.2	0.3	0.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	1.7	0.1	1.3	-0.7
Whole body fat-free mass	0.0	0.2	0.4	0.4	-0.6	-0.3
Leg fat-free mass (right)	0.0	0.1	0.3	0.5	-0.0	-0.4
Arm fat percentage (left)	1.0	3.9	11.5	0.2	3.4	-0.5
Average weekly red wine intake	0.2	0.4	1.1	-0.1	0.1	1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.5	0.0	-1.2	-0.6
Mood swings	1.0	1.7	2.6	-1.6	-1.6	-0.1
Loneliness, isolation	0.2	0.2	0.6	-0.2	0.8	-0.3
Long-standing illness, disability or infirmity	0.4	0.6	1.2	-0.0	-0.9	-1.1
Ever had bowel cancer screening	0.9	1.1	1.7	-1.1	1.3	0.7
Diabetes diagnosed by doctor	0.5	0.9	2.2	-0.4	0.5	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	4.6	0.4	-0.8	2.1
Friendships satisfaction	1.4	1.8	3.7	1.1	1.9	0.7
Qualifications: nursing, teaching	0.8	1.3	3.6	1.9	0.3	0.3
Commuting to job workplace: Walk	0.1	0.1	0.2	0.5	0.1	0.1
Eye problems/disorders: Cataract	1.1	1.2	2.3	-1.5	0.7	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.1	0.7	-0.8	1.4
Medication for cholesterol	1.8	2.8	4.5	-2.1	0.4	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.4	0.6	1.6	0.8
Back pain experienced in last month	2.8	4.1	6.9	-2.1	-0.9	-2.6
Mineral and other dietary supplements	0.6	0.8	1.3	-1.1	0.3	1.0
Breast cancer (self-reported)	1.0	1.2	1.7	1.1	0.9	1.3
Asthma (self-reported)	1.1	2.3	4.5	-1.3	-2.1	-0.8
Osteoporosis (self-reported)	0.5	0.6	1.6	-0.4	0.2	-1.2
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.5	-0.2	-0.7
Medication: Aspirin	0.8	1.1	1.3	-0.9	-1.1	-1.0
Medication: Gliclazide	1.2	1.4	3.0	-0.8	0.8	-1.7
Illnesses of father: None of the above (group 1)	1.0	1.3	2.2	1.1	1.5	0.6
Smoking status: Current	0.5	0.8	1.8	-0.5	0.5	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.1	0.5	-1.8	-0.5
Whole body water mass	0.0	0.2	0.3	0.5	-0.5	-0.3
Leg predicted mass (right)	0.0	0.1	0.2	0.5	-0.1	-0.5
Arm fat mass (left)	0.7	2.8	8.0	0.4	2.8	-0.6
Number of self-reported non-cancer illnesses	1.1	1.9	3.6	-1.1	-1.9	-0.9
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.4	0.3	-0.7
Miserableness	0.3	0.6	0.8	-0.9	0.4	-0.9
Guilty feelings	2.6	3.9	10.8	-3.3	-0.4	-0.9
Wears glasses or contact lenses	6.6	7.6	14.1	-2.1	-2.1	-3.7
Ever taken oral contraceptive pill	0.8	0.9	2.4	0.1	-1.5	0.4
Hearing aid user	0.9	1.0	2.6	1.6	0.4	0.4
Mother’s age at death	0.4	0.5	1.2	1.1	-0.1	0.5
Financial situation satisfaction	2.2	2.7	3.4	1.3	1.7	1.8
Tinnitus: Yes, now most or all of the time	1.5	1.8	4.3	1.0	0.0	-2.1
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.4	0.4	-0.1
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	0.5	0.6	-0.3
Medication: Blood pressure	0.2	0.4	0.8	0.9	-0.5	0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.5	-0.3	0.6	-0.7
Supplements: Fish oil (including cod liver oil)	0.9	1.1	1.9	1.1	-1.4	-0.6
High cholesterol (Self-reported)	1.9	3.4	9.5	-0.7	-3.1	-0.3
Medication: Bendroflumethiazide	0.4	0.6	0.9	0.6	-0.7	1.0
Medication: Paracetamol	0.5	0.8	1.4	1.0	1.2	0.1
Medication: Lisinopril	0.2	0.3	0.6	-0.7	-0.3	-0.5
Medication: Atorvastatin	1.3	1.6	3.5	0.2	-1.9	1.1
Illnesses of father: High blood pressure	0.3	0.4	0.6	0.4	-0.8	0.7
Alcohol drinker status: Never	0.7	0.8	2.3	0.1	0.3	1.5
Ever smoked	1.2	2.1	6.4	0.0	0.2	-2.5
Basal metabolic rate	0.0	0.1	0.3	0.5	0.1	-0.3
Leg fat percentage (left)	0.9	3.4	9.8	-0.0	3.1	-0.7
Arm fat-free mass (left)	0.0	0.2	0.2	0.4	-0.4	-0.4
Number of operations (self-reported)	0.3	0.4	0.8	0.9	-0.2	0.7
Average weekly beer plus cider intake	0.2	0.3	0.7	0.4	-0.1	0.8
Irritability	0.3	0.5	0.9	0.2	-0.9	-0.8
Risk taking	0.6	0.9	1.9	-0.3	-0.9	-1.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.4	-0.5	-0.2	1.2
Fractured/broken bones in last 5 years	0.4	0.5	0.8	0.3	0.9	-0.7
Age started oral contraceptive pill	0.3	0.3	0.5	0.4	0.7	0.6
Diastolic blood pressure, automated reading	0.3	0.9	2.0	0.8	1.4	-0.4
Ever depressed for a whole week	0.4	0.5	1.6	-0.2	-0.2	-1.2
Unable to work because of sickness or disability	1.3	1.7	2.5	1.2	1.6	1.1
Commuting to job workplace: Cycle	0.9	1.1	3.1	1.7	-0.1	0.4
Myopia	1.1	1.6	3.6	-0.6	-0.8	-1.9
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.3	0.6	-0.5
Cholesterol lowering medication	0.8	1.2	1.9	0.8	-1.1	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.3	0.4	0.3	0.6
Pain experienced in last month	0.1	0.2	0.6	0.8	-0.2	-0.1
Supplements: Calcium	0.0	0.0	0.0	-0.1	-0.0	-0.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	-1.1	-0.4	0.6
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.8	-1.9	-0.6	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.4	1.2	0.0	0.9
Heart disease (siblings)	0.3	0.4	0.8	0.4	-0.9	-0.5
Alcohol drinker status: Previous	0.0	0.0	0.1	0.3	-0.1	-0.2
Pack years of smoking	0.7	1.0	2.3	-1.5	-0.5	0.7
Impedance of whole body	0.1	0.7	0.9	0.7	1.0	0.8
Leg fat mass (left)	0.7	2.9	7.7	0.2	2.8	-0.9
Arm predicted mass (left)	0.0	0.2	0.4	0.7	-0.3	-0.4