Hub : Genes

NRIP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0800 0.0280 1.5e-03 0.030 0.008 -0.001 0.011 0.010 1.4e-04 2.8e-02 4.2e-01 1.6e-02 1.7e-02
2 YFS Blood 0.0363 0.0102 8.8e-06 0.017 0.015 0.019 0.015 0.020 1.9e-06 5.6e-06 5.0e-07 7.7e-06 2.8e-07
3 TCGA Prostate Adenocarcinoma 0.0919 0.0335 3.2e-05 0.090 0.061 0.076 NA 0.082 1.3e-09 5.3e-07 2.4e-08 NA 6.0e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.0 0.0 0.0 -0.1 -0.0 -0.0
Bipolar Disorder or Schizophrenia 0.9 2.2 6.4 -0.0 0.3 2.5
Depressed Affect (Nagel 2018) 0.3 0.6 1.0 -1.0 -0.7 -0.6
Depression (Nagel 2018) 0.7 1.1 1.9 -1.0 -1.4 0.7
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.4 -0.7 -0.6 -0.3
Neuroticism (Nagel 2018) 1.6 3.8 6.2 -2.5 -2.2 -0.5
Schizophrenia (2018) 1.8 3.6 10.8 0.1 0.4 3.3
Schizophrenia vs Biploar Disorder 2.0 2.6 4.8 0.3 -1.7 2.2
Worry (Nagel 2018) 2.3 4.9 11.9 -1.6 -3.5 -0.5
Alzheimer’s Disease (in mother) 1.0 1.2 2.5 1.0 0.1 1.6
Alzheimer’s Disease (in father) 0.7 0.7 2.0 -1.4 -0.2 0.4
Alzheimer’s Disease (including proxy) 0.4 0.6 1.6 -0.0 -0.5 1.3
Crohns Disease (2017) 5.1 11.1 32.4 -5.7 -1.0 -0.1
Irritable Bowel Disease (IBD) 5.2 12.5 36.6 -6.0 -0.8 -0.3
Ulcerative Colitis (UC) 3.1 5.9 17.3 -4.2 -0.5 -0.4
Major Depression (MDD) 2.4 2.9 3.6 -1.4 -1.8 -1.9
Reaction Time 0.6 1.1 2.7 1.6 -0.0 0.9
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.4 0.1 -0.1 0.7
Breast Cancer 0.1 0.2 0.3 -0.4 -0.3 -0.6
Ovarian Cancer 1.0 1.3 3.1 0.2 1.8 -0.9
Prostate Cancer 0.1 0.1 0.1 0.4 0.1 -0.2
Age at First Birth 1.3 1.9 3.6 1.9 0.7 1.3
Bipolar Disorder (2011) 0.7 0.7 1.9 -1.4 0.3 0.0
Body Mass Index (BMI) (2010) 0.2 0.3 0.6 -0.5 0.3 -0.7
Coronary Artery Disease (CAD) 2.2 2.7 7.1 -0.6 -2.7 0.7
Crohns Disease (2012) 3.3 5.3 15.4 -3.9 -0.4 -0.6
Mean Putamen Volume 0.1 0.1 0.3 -0.2 0.6 0.1
Fasting Glucose 1.8 2.1 6.1 0.3 -2.5 -0.4
HbA1C 0.5 0.6 1.1 -0.7 -1.0 0.3
HDL Cholesterol 1.9 3.2 8.4 1.0 0.4 2.9
LDL Cholesterol 1.3 2.0 4.8 -1.0 -0.5 -2.2
Lupus 1.2 1.8 3.5 -0.1 -1.9 1.4
Neuroticism (2016) 0.9 1.3 3.4 -0.7 -1.9 0.1
Primary Biliary Cirrhosis 0.4 0.5 0.9 1.0 0.5 0.6
Rheumatoid Arthritis 1.7 2.3 5.0 -1.1 0.8 2.2
Schizophrenia (2014) 0.8 1.7 4.8 -0.3 -0.5 2.2
Triglycerides 1.2 2.0 2.8 -1.7 -1.1 -1.3
Type 2 Diabetes (T2D) (2012) 1.4 1.6 3.9 -0.6 -2.0 -0.7
Ulcerative Colitis 2.2 3.2 6.0 -2.5 -1.5 -1.1
Blood Eosinophil Count 0.6 4.7 12.5 -3.5 -1.2 0.6
Blood Platelet Count 1.2 14.3 33.5 1.4 2.7 5.8
Blood Red Count 0.6 6.0 14.1 -3.8 1.5 -1.3
Blood White Count 1.4 10.6 26.9 1.5 1.6 5.2
Heel T-Score 0.1 0.9 1.3 0.5 1.1 1.1
BMI 0.4 2.0 3.9 0.7 2.0 -1.3
Height 0.1 1.8 2.6 1.6 -1.5 -0.7
Waist Hip Ratio (WHR) 0.1 0.2 0.7 -0.2 -0.1 -0.8
Systolic Blood Pressure 0.3 1.3 2.4 1.1 -0.6 1.6
Smoking Status 0.3 0.6 1.6 -0.3 -0.5 -1.2
Allergy or Eczema 1.0 2.5 6.4 -2.5 -1.1 0.0
Cardiovascular Disease 0.7 2.3 4.5 0.8 -2.1 1.3
Hypothyroidism (self reported) 3.0 6.9 18.0 -4.2 0.7 -1.5
Respiratory disease 0.5 1.1 2.3 -1.0 -1.5 -0.4
Type 2 Diabetes (T2D) (2018) 0.1 0.3 0.4 -0.6 0.4 -0.4
Lung FEV1/FVC ratio 0.2 1.2 2.3 1.0 1.5 -0.6
Lung FVC 0.6 2.9 8.4 0.6 -2.9 -0.3
Neuroticism 1.2 2.9 5.4 -1.6 -2.3 -0.8
Chronotype (morning person) 0.4 0.9 1.8 -1.4 0.2 -0.8
Hair Pigment 0.1 2.3 4.3 -2.1 -1.1 1.1
Tanning 0.0 0.1 0.3 -0.1 -0.4 0.5
Hand grip strength (left) 0.7 1.9 2.4 -1.4 -1.5 -1.1
Number of treatments/medications taken 1.2 2.2 4.5 -2.1 -1.1 -1.0
Average weekly spirits intake 3.2 3.9 6.4 -0.7 -2.5 -2.2
Sensitivity / hurt feelings 1.2 2.0 4.8 -2.2 -0.7 -0.7
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.5 -0.6 -1.6 0.4
Hearing difficulty/problems: Yes 1.0 1.5 2.5 0.4 -1.4 1.6
Relative age of first facial hair 1.2 2.4 4.0 0.2 1.8 -2.0
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.1 -1.0 0.6 -1.0
Ever used hormone-replacement therapy (HRT) 1.4 1.8 2.5 1.6 -0.6 1.6
Ever had hysterectomy (womb removed) 0.5 0.6 1.2 0.7 0.4 1.1
Systolic blood pressure, automated reading 0.1 0.3 0.8 0.9 -0.1 -0.1
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 3.5 -1.9 -0.6 -1.4
Angina 0.5 0.7 1.3 -1.1 -0.8 -0.2
Medication for hormone replacement therapy 2.1 2.3 2.8 1.5 1.7 1.4
Vitamin and mineral supplements 0.4 0.5 1.3 0.5 -0.2 1.1
Supplements: Zinc 0.5 0.5 1.4 -0.4 0.2 1.2
Medication: Co-codamol 0.5 0.6 0.9 -0.4 -1.0 -0.8
Medication: Metformin 0.6 0.9 2.7 -0.1 -0.1 -1.6
Diabetes (father) 0.7 0.9 2.5 -1.6 0.1 -0.3
Diabetes (mother) 0.5 0.7 1.0 0.5 -1.0 -0.8
Severe depression (siblings) 0.1 0.1 0.3 0.1 0.5 0.1
Pack years adult smoking proportion 0.8 1.2 2.8 -1.7 -0.8 0.3
Impedance of leg (right) 0.1 0.3 0.6 0.3 0.8 0.5
Leg fat-free mass (left) 0.0 0.2 0.3 0.6 0.3 -0.4
Trunk fat percentage 0.8 3.3 9.6 0.3 3.1 -0.3
Hand grip strength (right) 0.7 1.8 3.5 -1.4 -1.9 0.2
Townsend deprivation index at recruitment 0.7 1.0 1.3 0.8 1.1 1.2
Current tobacco smoking 0.6 0.9 2.3 -0.6 0.2 -1.5
Average weekly fortified wine intake 0.1 0.2 0.2 0.5 -0.4 -0.2
Maternal smoking around birth 0.0 0.1 0.1 0.4 0.1 -0.1
Fed-up feelings 0.1 0.1 0.2 -0.4 0.5 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.6 0.3 0.4 1.3
Relative age voice broke 0.5 0.8 1.8 0.4 0.7 -1.3
Taking other prescription medications 2.9 4.5 12.1 -3.5 -1.1 -0.5
Age when periods started (menarche) 0.2 0.6 1.7 0.1 1.3 0.2
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.1 -0.7 0.1 1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 1.9 -1.4 -1.0 -0.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 0.1 -0.1 -0.5
Qualifications: CSEs or equivalent 0.3 0.5 1.4 -0.0 1.2 -0.1
Serious illness, injury or assault to yourself 1.1 1.3 2.4 1.5 -1.1 0.5
High blood pressure 0.1 0.2 0.4 0.5 -0.2 0.6
Hayfever, allergic rhinitis or eczema 1.1 2.4 6.3 -2.5 -0.9 -0.5
Multivitamins +/- minerals 0.4 0.5 0.8 0.9 0.5 0.6
Stomach or abdominal pain in last month 0.2 0.2 0.6 -0.3 -0.8 -0.0
Supplements: Glucosamine 1.0 1.3 3.6 1.9 0.5 -0.3
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.3 0.8 -0.2 1.1
Medication: Atenolol 3.6 4.5 7.4 -2.7 -0.5 -2.4
Medication: Levothyroxine sodium 2.9 4.8 12.7 -3.6 -0.2 -1.3
Sitting height 0.1 0.8 1.7 1.3 -0.7 0.3
Chronic bronchitis/emphysema (father) 0.7 0.9 1.8 0.3 0.8 -1.3
High blood pressure (mother) 1.3 1.8 2.6 1.4 1.6 1.0
Body mass index (BMI) 0.6 2.6 6.9 -0.0 2.6 -0.9
Impedance of leg (left) 0.1 0.4 0.9 0.1 0.9 0.4
Leg predicted mass (left) 0.0 0.2 0.3 0.6 0.2 -0.4
Trunk fat mass 0.6 2.4 6.8 0.4 2.6 -0.3
Waist circumference 0.6 2.2 6.2 0.0 2.5 -0.6
Number of incorrect matches in round 0.2 0.3 0.7 0.8 -0.4 -0.2
Past tobacco smoking 0.6 1.1 2.4 -0.8 -0.4 1.6
Alcohol usually taken with meals 0.6 1.0 1.3 -0.9 0.9 1.1
Nervous feelings 1.6 3.0 6.3 -1.3 -2.5 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.8 -0.3 -0.9 0.6
Hearing difficulty/problems with background noise 0.2 0.3 0.4 0.1 -0.6 -0.6
Hair/balding pattern: Pattern 2 0.3 0.4 1.0 -0.6 -1.0 0.0
Had menopause 0.1 0.2 0.5 0.7 -0.1 -0.1
Had other major operations 2.1 2.5 5.2 -0.8 -2.3 1.3
Forced vital capacity (FVC) 1.4 5.5 15.6 0.9 -3.9 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.9 -0.6 -0.2 0.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.7 0.6 -0.6 -0.8
Qualifications: None of the above 0.6 1.3 2.3 -1.2 1.5 0.4
Financial difficulties in last 2 years 0.3 0.3 0.7 0.4 0.4 0.8
Mouth/teeth dental problems 1.0 1.5 4.4 0.1 2.1 -0.4
Heart attack 1.5 1.9 4.5 -2.1 -0.7 -0.7
Allergy 2.4 5.4 10.5 3.2 2.1 1.2
Pain all over the body in last month 0.6 0.6 1.7 0.1 1.3 -0.2
Diabetes (self-reported) 0.4 0.6 1.4 -0.4 0.5 -1.2
Hayfever/allergic rhinitis (self-reported) 3.3 4.3 7.7 -2.8 -1.4 -1.8
Medication: Ramipril 0.5 0.6 1.3 0.7 0.3 1.1
Medication: Simvastatin 1.0 1.5 2.1 -1.1 -1.0 -1.5
Fluid intelligence score 0.3 0.6 1.5 1.2 0.1 0.5
Illnesses of siblings 0.2 0.2 0.5 0.7 0.4 -0.2
Neuroticism score 1.0 2.2 4.3 -1.3 -2.1 -0.7
Weight 0.3 1.5 3.9 0.5 2.0 -0.7
Impedance of arm (right) 0.1 0.5 1.1 0.4 0.4 1.0
Arm fat percentage (right) 0.8 3.1 9.2 0.1 3.0 -0.2
Trunk fat-free mass 0.1 0.5 1.3 0.2 -1.2 -0.4
Hip circumference 0.8 3.2 9.2 0.6 3.0 -0.3
Time employed in main current job 0.9 1.0 2.8 -0.2 0.3 1.7
Alcohol intake versus 10 years previously 0.0 0.0 0.0 0.1 -0.1 -0.1
Father’s age at death 0.4 0.5 1.1 0.2 1.1 0.6
Worrier / anxious feelings 1.0 1.9 3.5 -1.4 -1.9 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 -0.2 0.5 -0.3
Falls in the last year 0.9 1.2 1.8 1.2 1.4 -0.4
Hair/balding pattern: Pattern 3 1.0 1.4 3.2 0.9 1.8 -0.5
Number of live births 0.8 1.1 1.9 1.0 0.7 1.4
Forced expiratory volume in 1-second (FEV1) 1.0 3.5 8.9 1.0 -3.0 -0.7
Pulse rate 1.3 2.3 6.4 -2.5 0.2 0.6
Happiness 0.3 0.4 0.7 0.9 0.5 0.4
Noisy workplace 2.1 2.6 4.1 -0.4 -1.9 -2.0
Qualifications: A levels/AS levels or equivalent 1.8 4.0 8.0 2.8 0.2 2.0
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.8 1.3 0.8 0.2
Mouth/teeth dental problems: Dentures 0.8 1.3 2.3 -1.2 -1.5 -0.4
Asthma 1.4 2.7 5.7 -1.4 -2.4 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.2 0.5 1.1 0.6
Medication: Cholesterol lowering 1.9 3.0 5.9 -1.7 -2.4 0.3
Depression (self-reported) 0.1 0.1 0.2 -0.3 -0.4 -0.2
Medication: Lansoprazole 0.9 1.1 1.4 -1.2 -1.1 -0.8
Prospective memory result 0.6 0.7 1.1 -1.0 0.4 -1.0
Lung cancer (father) 0.0 0.0 0.1 0.3 0.1 0.3
Illnesses of mother 1.0 1.2 2.5 -1.1 0.1 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 7.8 0.8 -2.8 0.0
Pulse wave Arterial Stiffness index 1.4 1.6 3.1 -1.8 0.7 -1.1
Impedance of arm (left) 0.1 0.7 1.4 0.6 1.2 0.6
Arm fat mass (right) 0.7 2.9 8.5 0.3 2.9 -0.4
Trunk predicted mass 0.1 0.6 1.5 0.3 -1.2 -0.4
Standing height 0.1 0.9 1.6 1.0 -1.3 -0.1
Length of working week for main job 1.2 1.3 3.8 1.9 0.2 -0.1
Exposure to tobacco smoke at home 1.1 1.2 2.5 1.0 -0.1 1.6
Breastfed as a baby 0.3 0.4 1.0 0.5 -0.3 1.0
Tense / ‘highly strung’ 0.8 1.4 2.8 1.1 -1.7 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.8 3.8 -1.2 -1.8 2.0
Hair/balding pattern: Pattern 4 0.6 1.4 4.0 -2.0 -0.3 -0.2
Birth weight of first child 2.1 3.8 7.5 -2.0 -0.2 -2.7
Peak expiratory flow (PEF) 1.6 3.7 10.4 0.8 -3.2 -0.0
Pulse wave reflection index 0.2 0.2 0.7 0.0 -0.0 -0.9
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 0.3 -0.1 -0.7
Loud music exposure frequency 0.7 0.7 2.1 0.0 -1.5 0.1
Qualifications: O levels/GCSEs or equivalent 2.5 3.9 4.4 2.1 2.1 1.7
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 0.7 -0.4 -0.3 0.8
Blood clot in the leg (DVT) 0.8 1.0 1.8 1.4 0.4 1.1
Medication: Paracetamol 1.4 2.3 3.9 1.7 2.0 0.3
Headache pain in last month 0.3 0.6 1.1 -0.1 -1.1 -0.7
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.7 1.6 1.2 0.1
Glaucoma (self-reported) 0.1 0.1 0.2 0.2 0.2 -0.4
Gout (self-reported) 0.0 0.0 0.1 -0.3 -0.2 -0.1
Hypothyroidism/myxoedema (self-reported) 3.8 7.4 17.0 -4.1 0.7 -2.2
Medication: Amlodipine 0.4 0.5 1.2 0.6 -1.1 -0.2
Medication: Ventolin 100micrograms inhaler 2.1 2.7 5.8 -1.5 -2.4 0.0
Birth weight 0.9 1.9 3.2 -1.4 -0.7 -1.8
Chronic bronchitis/emphysema (mother) 1.2 1.3 4.0 -0.2 0.1 2.0
High blood pressure (siblings) 0.7 1.0 2.9 -0.2 -0.0 1.7
Forced vital capacity (FVC), Best measure 1.3 4.7 13.3 0.7 -3.6 0.7
Body fat percentage 1.0 3.9 11.5 0.4 3.4 -0.2
Leg fat percentage (right) 0.8 3.0 8.9 -0.1 3.0 -0.5
Arm fat-free mass (right) 0.1 0.4 0.5 0.6 -0.6 -0.7
Exposure to tobacco smoke outside home 0.8 1.0 1.3 1.1 1.1 0.8
Comparative body size at age 10 0.9 2.5 4.7 0.4 2.2 -1.6
Number of full brothers 0.5 0.6 0.8 0.8 -0.9 0.5
Worry too long after embarrassment 1.6 2.7 6.6 -2.6 -1.0 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.1 0.1 -0.3 0.2 -0.1
Wheeze or whistling in the chest in last year 1.4 2.4 4.6 -2.2 -0.9 -1.3
Number of children fathered 0.8 1.0 2.5 0.5 1.6 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.1 0.3 1.5 -0.7
Age at first live birth 0.8 1.5 4.1 -0.4 -2.0 -0.4
Pulse wave peak to peak time 1.5 1.8 3.3 1.8 -0.9 1.1
Health satisfaction 0.3 0.4 1.0 0.1 -0.5 1.0
Shortness of breath walking on level ground 0.1 0.1 0.4 0.2 -0.6 -0.0
Qualifications: College or University degree 0.1 0.3 0.6 -0.7 0.1 0.8
Eye problems/disorders: None of the above 1.7 2.0 4.4 2.1 0.1 1.2
Mouth/teeth dental problems: Loose teeth 3.9 4.7 13.2 -0.8 0.3 -3.6
Emphysema/chronic bronchitis 2.4 2.7 6.1 0.4 -2.5 -1.4
Medication for pain relief, constipation, heartburn 0.9 1.5 2.5 -1.1 -1.6 -0.9
Neck or shoulder pain in last month 0.5 0.7 1.7 -1.3 -0.6 -0.1
Medication: Blood pressure 0.4 0.8 1.7 -1.3 -0.7 -0.3
Angina (self-reported) 0.7 1.0 2.1 -1.4 -0.9 -0.3
Migraine (self-reported) 2.6 3.2 4.6 2.0 2.1 1.1
Medication: Ibuprofen 0.2 0.3 0.5 0.7 0.4 0.3
Medication: Allopurinol 0.1 0.2 0.3 -0.1 0.5 0.6
Medication: Omeprazole 0.2 0.2 0.5 0.0 0.3 0.7
Medication: Seretide 50 evohaler 1.4 1.6 3.6 0.6 -1.9 -0.9
Mean time to correctly identify matches 0.5 0.9 1.6 1.3 0.2 1.0
Heart disease (mother) 0.4 0.5 0.8 -0.3 -0.9 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 2.6 -1.6 1.2 -0.5
Whole body fat mass 0.7 2.8 8.0 0.2 2.8 -0.7
Leg fat mass (right) 0.7 2.7 7.3 0.2 2.7 -0.9
Arm predicted mass (right) 0.1 0.4 0.7 0.7 -0.3 -0.8
Pulse rate, automated reading 0.1 0.3 0.6 0.4 0.8 0.4
Alcohol intake frequency. 0.2 0.5 1.1 -0.3 0.6 -1.0
Comparative height size at age 10 0.2 1.2 3.0 0.8 -1.7 0.4
Number of full sisters 0.8 1.0 2.7 1.6 0.6 -0.0
Suffer from ‘nerves’ 2.4 3.8 11.0 -0.2 -3.3 0.6
Overall health rating 0.4 0.9 1.9 -0.2 0.9 1.4
Chest pain or discomfort 0.7 0.9 1.9 -1.4 -0.3 -0.9
Had major operations 0.7 0.9 1.5 -1.2 0.8 -0.7
Age at last live birth 0.2 0.2 0.4 -0.2 -0.6 -0.6
Family relationship satisfaction 1.1 1.3 1.8 1.4 -1.2 0.8
Leg pain on walking 0.7 0.9 2.5 -0.3 -0.4 -1.6
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.9 0.9 0.4 -0.3
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.2 -1.1 0.4 0.4
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.9 -1.4 -0.1 0.2
Medication: Aspirin 0.6 0.8 1.2 -0.5 -1.1 -1.0
Supplements: Vitamin C 0.0 0.0 0.1 -0.1 0.3 0.0
Knee pain experienced in last month 0.2 0.3 0.9 -0.0 0.2 0.9
Hypertension (Self-reported) 0.1 0.4 0.7 0.6 0.3 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.1 3.6 -0.9 -1.4 -1.9
Illnesses of father: Heart disease 1.8 2.5 3.1 -1.6 -1.8 1.3
Illnesses of siblings: Diabetes 2.7 3.3 7.2 -1.6 -0.5 -2.7
Smoking status: Previous 0.3 0.5 1.2 0.3 0.4 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.7 1.7 0.1 1.3 -0.7
Whole body fat-free mass 0.0 0.2 0.4 0.4 -0.6 -0.3
Leg fat-free mass (right) 0.0 0.1 0.3 0.5 -0.0 -0.4
Arm fat percentage (left) 1.0 3.9 11.5 0.2 3.4 -0.5
Average weekly red wine intake 0.2 0.4 1.1 -0.1 0.1 1.0
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.5 0.0 -1.2 -0.6
Mood swings 1.0 1.7 2.6 -1.6 -1.6 -0.1
Loneliness, isolation 0.2 0.2 0.6 -0.2 0.8 -0.3
Long-standing illness, disability or infirmity 0.4 0.6 1.2 -0.0 -0.9 -1.1
Ever had bowel cancer screening 0.9 1.1 1.7 -1.1 1.3 0.7
Diabetes diagnosed by doctor 0.5 0.9 2.2 -0.4 0.5 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 4.6 0.4 -0.8 2.1
Friendships satisfaction 1.4 1.8 3.7 1.1 1.9 0.7
Qualifications: nursing, teaching 0.8 1.3 3.6 1.9 0.3 0.3
Commuting to job workplace: Walk 0.1 0.1 0.2 0.5 0.1 0.1
Eye problems/disorders: Cataract 1.1 1.2 2.3 -1.5 0.7 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.1 0.7 -0.8 1.4
Medication for cholesterol 1.8 2.8 4.5 -2.1 0.4 -1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.4 0.6 1.6 0.8
Back pain experienced in last month 2.8 4.1 6.9 -2.1 -0.9 -2.6
Mineral and other dietary supplements 0.6 0.8 1.3 -1.1 0.3 1.0
Breast cancer (self-reported) 1.0 1.2 1.7 1.1 0.9 1.3
Asthma (self-reported) 1.1 2.3 4.5 -1.3 -2.1 -0.8
Osteoporosis (self-reported) 0.5 0.6 1.6 -0.4 0.2 -1.2
Osteoarthritis (self-reported) 0.2 0.3 0.5 0.5 -0.2 -0.7
Medication: Aspirin 0.8 1.1 1.3 -0.9 -1.1 -1.0
Medication: Gliclazide 1.2 1.4 3.0 -0.8 0.8 -1.7
Illnesses of father: None of the above (group 1) 1.0 1.3 2.2 1.1 1.5 0.6
Smoking status: Current 0.5 0.8 1.8 -0.5 0.5 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 3.1 0.5 -1.8 -0.5
Whole body water mass 0.0 0.2 0.3 0.5 -0.5 -0.3
Leg predicted mass (right) 0.0 0.1 0.2 0.5 -0.1 -0.5
Arm fat mass (left) 0.7 2.8 8.0 0.4 2.8 -0.6
Number of self-reported non-cancer illnesses 1.1 1.9 3.6 -1.1 -1.9 -0.9
Average weekly champagne plus white wine intake 0.2 0.2 0.5 0.4 0.3 -0.7
Miserableness 0.3 0.6 0.8 -0.9 0.4 -0.9
Guilty feelings 2.6 3.9 10.8 -3.3 -0.4 -0.9
Wears glasses or contact lenses 6.6 7.6 14.1 -2.1 -2.1 -3.7
Ever taken oral contraceptive pill 0.8 0.9 2.4 0.1 -1.5 0.4
Hearing aid user 0.9 1.0 2.6 1.6 0.4 0.4
Mother’s age at death 0.4 0.5 1.2 1.1 -0.1 0.5
Financial situation satisfaction 2.2 2.7 3.4 1.3 1.7 1.8
Tinnitus: Yes, now most or all of the time 1.5 1.8 4.3 1.0 0.0 -2.1
Commuting to job workplace: Public transport 0.1 0.1 0.2 -0.4 0.4 -0.1
Eye problems/disorders: Glaucoma 0.2 0.3 0.4 0.5 0.6 -0.3
Medication: Blood pressure 0.2 0.4 0.8 0.9 -0.5 0.5
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.5 -0.3 0.6 -0.7
Supplements: Fish oil (including cod liver oil) 0.9 1.1 1.9 1.1 -1.4 -0.6
High cholesterol (Self-reported) 1.9 3.4 9.5 -0.7 -3.1 -0.3
Medication: Bendroflumethiazide 0.4 0.6 0.9 0.6 -0.7 1.0
Medication: Paracetamol 0.5 0.8 1.4 1.0 1.2 0.1
Medication: Lisinopril 0.2 0.3 0.6 -0.7 -0.3 -0.5
Medication: Atorvastatin 1.3 1.6 3.5 0.2 -1.9 1.1
Illnesses of father: High blood pressure 0.3 0.4 0.6 0.4 -0.8 0.7
Alcohol drinker status: Never 0.7 0.8 2.3 0.1 0.3 1.5
Ever smoked 1.2 2.1 6.4 0.0 0.2 -2.5
Basal metabolic rate 0.0 0.1 0.3 0.5 0.1 -0.3
Leg fat percentage (left) 0.9 3.4 9.8 -0.0 3.1 -0.7
Arm fat-free mass (left) 0.0 0.2 0.2 0.4 -0.4 -0.4
Number of operations (self-reported) 0.3 0.4 0.8 0.9 -0.2 0.7
Average weekly beer plus cider intake 0.2 0.3 0.7 0.4 -0.1 0.8
Irritability 0.3 0.5 0.9 0.2 -0.9 -0.8
Risk taking 0.6 0.9 1.9 -0.3 -0.9 -1.4
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.4 -0.5 -0.2 1.2
Fractured/broken bones in last 5 years 0.4 0.5 0.8 0.3 0.9 -0.7
Age started oral contraceptive pill 0.3 0.3 0.5 0.4 0.7 0.6
Diastolic blood pressure, automated reading 0.3 0.9 2.0 0.8 1.4 -0.4
Ever depressed for a whole week 0.4 0.5 1.6 -0.2 -0.2 -1.2
Unable to work because of sickness or disability 1.3 1.7 2.5 1.2 1.6 1.1
Commuting to job workplace: Cycle 0.9 1.1 3.1 1.7 -0.1 0.4
Myopia 1.1 1.6 3.6 -0.6 -0.8 -1.9
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.4 -0.3 0.6 -0.5
Cholesterol lowering medication 0.8 1.2 1.9 0.8 -1.1 -1.4
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.3 0.4 0.3 0.6
Pain experienced in last month 0.1 0.2 0.6 0.8 -0.2 -0.1
Supplements: Calcium 0.0 0.0 0.0 -0.1 -0.0 -0.0
Basal cell carcinoma (self-reported) 0.5 0.6 1.2 -1.1 -0.4 0.6
Heart attack/myocardial infarction (self-reported) 1.2 1.5 3.8 -1.9 -0.6 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 1.4 1.2 0.0 0.9
Heart disease (siblings) 0.3 0.4 0.8 0.4 -0.9 -0.5
Alcohol drinker status: Previous 0.0 0.0 0.1 0.3 -0.1 -0.2
Pack years of smoking 0.7 1.0 2.3 -1.5 -0.5 0.7
Impedance of whole body 0.1 0.7 0.9 0.7 1.0 0.8
Leg fat mass (left) 0.7 2.9 7.7 0.2 2.8 -0.9
Arm predicted mass (left) 0.0 0.2 0.4 0.7 -0.3 -0.4