Hub : Traits :

Irritable Bowel Disease (IBD)

1340 significantly associated models · 289 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 2404256 5 2 3.6e-08 3.3e-08 2.1e-02 83 CPSF3L SLC35E2
2 1 7314655 8776719 2 1 7.6e-14 2.2e-15 4.0e-03 87 PARK7
3 1 19658506 21114833 1 1 3.6e-16 6.3e-20 1.3e-07 67 PLA2G5
4 1 66527848 68559650 3 2 1.0e-12 4.8e-111 1.5e-93 16 IL12RB2 MIER1
5 1 149854324 151637065 8 1 8.5e-09 3.0e-11 4.2e-04 72 HORMAD1
6 1 154325302 156572984 19 2 1.0e-11 1.6e-10 5.0e-01 99 ADAM15 GBAP1
7 1 160107588 162630958 3 3 4.2e-13 2.0e-20 9.1e-03 92 ATF6 CD244 RP11-122G18.5
8 1 200014178 201528243 1 1 7.3e-11 1.0e-21 2.4e-14 37 CAMSAP2
9 1 209265152 210674209 2 1 2.0e-09 1.2e-08 7.7e-01 100 RP3-434O14.8
10 2 24324172 25837917 3 1 4.5e-13 7.6e-11 8.5e-01 100 ADCY3
11 2 26883355 29344127 2 2 5.3e-11 9.2e-12 3.1e-02 90 AC074117.10 RP11-373D23.3
12 2 42753863 44157441 2 1 1.0e-09 5.7e-10 1.0e-06 38 AC010883.5
13 2 60466491 62460013 10 1 8.3e-21 2.7e-28 2.2e-09 71 AC010733.5
14 2 101981794 103767612 4 1 2.3e-12 1.4e-11 9.8e-03 85 IL1R1
15 2 199443880 201021954 1 1 1.5e-07 6.4e-09 3.2e-07 22 SATB2
16 2 218296003 219878756 8 1 4.8e-10 1.2e-09 3.3e-02 88 ARPC2
17 2 233227833 234904144 2 1 2.2e-28 5.4e-29 1.0e+00 100 ATG16L1
18 2 240827284 242991746 3 3 5.7e-08 2.2e-14 1.0e-03 82 AC005104.3 CAPN10 GPR35
19 3 46323859 51043528 37 2 1.2e-33 1.2e-35 1.0e+00 100 APEH NBEAL2
20 4 122377715 123976639 1 1 1.7e-10 1.4e-11 5.5e-03 83 KIAA1109
21 5 9999146 11452037 1 1 3.4e-07 7.1e-07 6.3e-02 86 DAP
22 5 39986432 41555158 2 2 3.9e-19 3.6e-40 4.5e-22 47 CARD6 PTGER4
23 5 95027958 97065386 4 2 1.5e-11 6.8e-11 1.0e+00 100 ERAP2 PCSK1
24 5 129797129 132900729 16 2 5.0e-28 3.7e-27 1.7e-02 95 SLC22A5
25 5 140789933 142230251 1 1 2.4e-10 3.5e-10 2.9e-01 97 NDFIP1
26 5 149390148 151024052 4 1 2.6e-16 5.2e-16 1.0e+00 100 ZNF300P1
27 5 157889391 159448136 2 1 4.0e-10 4.4e-32 6.0e-24 27 IL12B
28 5 172620700 174083333 1 1 4.1e-07 3.0e-04 5.7e-01 98 CPEB4
29 5 176086479 177426530 1 1 1.6e-10 3.0e-10 1.0e+00 100 RGS14
30 6 110883139 112605814 2 1 1.9e-08 1.6e-10 1.8e-03 76 TRAF3IP2-AS1
31 6 166651581 167841508 3 1 2.8e-17 3.5e-18 6.9e-03 90 RNASET2
32 7 2032803 3510741 1 1 1.2e-07 1.6e-07 4.1e-01 98 AMZ1
33 7 73425238 74494207 2 1 7.1e-08 1.3e-06 7.8e-01 100 PMS2P5
34 7 98282214 100979310 2 2 4.0e-09 5.5e-09 5.1e-07 26 ARPC1B GIGYF1
35 7 106847492 108340749 2 1 9.5e-14 8.2e-16 5.5e-04 82 DLD
36 9 4287179 6472714 3 1 2.5e-21 3.1e-26 1.5e-06 79 IGHEP2
37 9 116849447 118266112 1 1 1.3e-24 4.1e-27 2.6e-05 85 TNFSF15
38 9 138126646 140373789 12 3 6.3e-35 3.5e-36 1.0e+00 100 CARD9 RP11-611D20.2
39 10 34607015 36198981 3 1 2.0e-12 9.1e-13 1.0e+00 100 RP11-297A16.2
40 10 63253359 65264300 3 2 9.7e-17 2.3e-36 3.8e-22 41 ADO RTKN2
41 10 74740461 76225597 2 1 2.9e-07 1.9e-07 1.9e-01 94 AGAP5
42 10 80130592 82984432 2 2 4.4e-11 3.6e-12 3.9e-05 65 TSPAN14 ZMIZ1
43 10 93657148 95110026 1 1 2.0e-07 4.1e-08 6.9e-02 89 KIF11
44 11 75369353 77069746 3 3 3.1e-14 1.8e-28 7.3e-09 73 LRRC32 PRKRIR
45 12 39904158 41454590 1 1 2.5e-10 7.9e-17 4.9e-08 57 LRRK2
46 12 67971319 69424500 1 1 7.8e-08 1.9e-25 5.8e-20 23 MDM1
47 12 111873167 113289070 1 1 1.1e-07 1.8e-11 1.2e-05 58 TRAFD1
48 15 66662107 68183665 1 1 1.1e-12 3.0e-21 4.4e-10 56 SMAD3
49 16 10646170 12426645 3 2 1.3e-11 1.2e-09 3.8e-01 98 LITAF RMI2
50 16 27412414 30141258 28 1 1.1e-16 4.8e-15 2.0e-01 97 SULT1A1
51 16 49403920 51535063 7 9 1.5e-32 1.8e-45 NaN NaN ADCY7 BRD7 CYLD NKD1 NOD2 PAPD5
52 17 36710513 39048774 15 2 3.5e-27 1.7e-29 5.3e-03 94 CASC3 PNMT
53 17 39328012 41699963 11 7 6.9e-16 1.3e-18 NaN NaN FAM134C HSD17B1P1 NAGLU PTRF RP11-400F19.8 STAT5A
54 19 389805 1802433 2 1 5.9e-13 4.2e-17 1.5e-08 55 POLR2E
55 19 9829303 11275258 1 1 7.3e-11 1.4e-13 9.7e-06 64 PDE4A
56 19 40534637 41938222 1 1 4.6e-08 2.2e-07 6.5e-01 99 ITPKC
57 20 57072048 58529763 1 1 1.4e-08 7.4e-10 7.0e-04 70 ZNF831
58 20 61522825 62912463 10 2 1.6e-23 1.8e-18 6.1e-02 95 RTEL1 STMN3
59 21 15634304 17135372 1 1 1.4e-09 7.5e-31 5.2e-23 27 NRIP1
60 21 44948764 46443886 2 3 4.6e-10 1.8e-24 1.3e-07 73 ICOSLG PFKL
61 22 21053389 22685340 5 1 3.1e-15 3.6e-15 1.0e+00 100 UBE2L3
62 22 29304253 31118395 2 1 3.3e-09 8.4e-10 1.1e-03 72 MTMR3
63 22 38719189 40529415 3 2 2.8e-20 4.6e-24 2.0e-09 65 APOBEC3D SYNGR1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 20.86 77 58 175.8 0.98 7.9e-58 AC010733.5 AC010883.5 AC074117.10 ADAM15 ADCY3 ADCY7 ADO AGAP5 APEH APOBEC3D ARPC1B ARPC2 ATG16L1 BRD7 CAMSAP2 CARD6 CARD9 CD244 CPEB4 CPSF3L CYLD DAP ERAP2 FAM134C GBAP1 GIGYF1 HORMAD1 ICOSLG IGHEP2 IL12B IL12RB2 IL1R1 ITPKC KIAA1109 KIF11 LITAF LRRC32 LRRK2 MIER1 MTMR3 NAGLU NDFIP1 NKD1 NOD2 NRIP1 PAPD5 PARK7 PCSK1 PDE4A PFKL PMS2P5 PNMT POLR2E PTGER4 PTRF RGS14 RMI2 RNASET2 RP11-297A16.2 RP11-373D23.3 RP11-400F19.8 RP11-611D20.2 RP3-434O14.8 RTEL1 SLC22A5 SMAD3 STAT5A STMN3 SULT1A1 SYNGR1 TNFSF15 TRAFD1 TSPAN14 UBE2L3 ZMIZ1 ZNF300P1 ZNF831
Ulcerative Colitis (UC) 12.37 55 27 81.8 0.97 3.4e-35 AC010733.5 ADO AMZ1 APEH ARPC2 ATF6 BRD7 CAMSAP2 CAPN10 CARD6 CARD9 CASC3 CPSF3L DLD FAM134C GBAP1 GPR35 HORMAD1 HSD17B1P1 ICOSLG IGHEP2 IL12B IL12RB2 IL1R1 KIAA1109 LRRC32 MDM1 MTMR3 NAGLU NRIP1 PARK7 PFKL PLA2G5 PNMT PRKRIR PTRF RGS14 RMI2 RP11-122G18.5 RP11-611D20.2 RP3-434O14.8 RTEL1 RTKN2 SATB2 SLC22A5 SLC35E2 SMAD3 STMN3 SULT1A1 SYNGR1 TNFSF15 TRAF3IP2-AS1 UBE2L3 ZNF300P1 ZNF831
Reaction Time 1.05 1 0 0.0 0.00 1.0e+00 ADCY3
Verbal and Numeric Reasoning (VNR) 1.33 4 2 6.1 -0.17 8.3e-01 ADCY3 APEH NBEAL2 SULT1A1
Breast Cancer 1.63 8 3 9.1 -0.49 2.2e-01 ADCY3 APEH GBAP1 HSD17B1P1 NAGLU PARK7 PMS2P5 RP11-400F19.8
Age at First Birth 1.10 1 1 3.0 0.00 1.0e+00 APEH
Body Mass Index (BMI) (2010) 1.14 2 1 3.0 0.00 1.0e+00 ADCY3 SULT1A1
Coronary Artery Disease (CAD) 1.48 1 0 0.0 0.00 1.0e+00 HORMAD1
Crohns Disease (2012) 15.95 48 34 103.0 -0.98 2.0e-35 AC010733.5 ADAM15 ADCY3 ADCY7 ADO AGAP5 APEH ATG16L1 BRD7 CARD6 CARD9 CPEB4 CYLD ERAP2 FAM134C GBAP1 IGHEP2 IL12B IL12RB2 IL1R1 LRRC32 LRRK2 MIER1 NAGLU NDFIP1 NKD1 NOD2 PAPD5 PCSK1 PDE4A PFKL PNMT PTGER4 PTRF RNASET2 RP11-297A16.2 RP11-400F19.8 RTEL1 SLC22A5 SMAD3 STMN3 SULT1A1 SYNGR1 TNFSF15 TSPAN14 UBE2L3 ZMIZ1 ZNF300P1
Fasting Glucose 1.68 1 1 3.0 0.00 1.0e+00 AC074117.10
HDL Cholesterol 1.39 2 2 6.1 0.00 1.0e+00 PNMT UBE2L3
Lupus 1.98 3 1 3.0 0.00 1.0e+00 ATF6 IL12RB2 UBE2L3
Primary Biliary Cirrhosis 2.85 4 4 12.1 -0.54 4.6e-01 IL12RB2 PNMT RMI2 SYNGR1
Rheumatoid Arthritis 2.02 2 0 0.0 0.00 1.0e+00 LRRC32 PNMT
Schizophrenia 0.93 1 1 3.0 0.00 1.0e+00 GIGYF1
Triglycerides 3.49 2 1 3.0 0.00 1.0e+00 AC074117.10 RP11-373D23.3
Type 2 Diabetes (T2D) 1.51 1 1 3.0 0.00 1.0e+00 KIF11
Ulcerative Colitis 10.50 28 13 39.4 -0.96 2.9e-16 AC010733.5 AMZ1 APEH ARPC2 ATF6 BRD7 CAMSAP2 CAPN10 CARD9 DLD IGHEP2 IL1R1 LRRC32 LRRK2 MDM1 PARK7 PLA2G5 PNMT PTRF RP11-122G18.5 RP11-297A16.2 RTEL1 SATB2 SLC22A5 STMN3 SYNGR1 TNFSF15 TRAF3IP2-AS1
Blood Eosinophil Count 5.06 28 22 66.7 -0.24 2.0e-01 AC005104.3 AC010883.5 ADCY3 ADO AMZ1 CAMSAP2 CARD9 CASC3 DAP ERAP2 GIGYF1 GPR35 HORMAD1 HSD17B1P1 IGHEP2 KIAA1109 KIF11 LRRC32 NDFIP1 PFKL PRKRIR RGS14 RP11-297A16.2 SLC22A5 SMAD3 TNFSF15 TRAFD1 UBE2L3
Blood Platelet Count 2.50 25 19 57.6 -0.09 6.5e-01 AC010883.5 AC074117.10 ADAM15 ADO AMZ1 ARPC2 ATG16L1 CAPN10 GBAP1 HORMAD1 IGHEP2 MTMR3 NBEAL2 NDFIP1 PARK7 PNMT PTGER4 RMI2 RP11-122G18.5 RTEL1 SLC22A5 STMN3 SULT1A1 TRAFD1 ZMIZ1
Blood Red Count 1.20 16 11 33.3 -0.25 3.6e-01 AC005104.3 DAP GBAP1 GIGYF1 IGHEP2 KIF11 NDFIP1 PNMT POLR2E PTGER4 RGS14 RTEL1 STMN3 SULT1A1 TRAF3IP2-AS1 TRAFD1
Blood White Count 3.46 30 21 63.6 0.00 1.0e+00 AC010733.5 AC074117.10 ADCY3 ADO AMZ1 APEH ARPC1B ARPC2 ATF6 CARD9 CPEB4 ERAP2 ITPKC NAGLU NBEAL2 NDFIP1 PAPD5 PDE4A PNMT POLR2E RGS14 RNASET2 RP11-373D23.3 RP11-400F19.8 RTEL1 SLC22A5 STMN3 TRAFD1 TSPAN14 UBE2L3
Heel T-Score 0.90 13 8 24.2 0.12 7.0e-01 AC010883.5 AMZ1 APEH ARPC2 CAMSAP2 GBAP1 HORMAD1 NBEAL2 PMS2P5 SATB2 STAT5A TSPAN14 UBE2L3
BMI 1.60 8 5 15.2 -0.34 4.2e-01 ADCY3 APEH ARPC1B HORMAD1 PMS2P5 RTEL1 SULT1A1 TRAFD1
Height 1.60 25 19 57.6 -0.17 4.0e-01 AC005104.3 AC010883.5 AC074117.10 ADCY3 ADO AMZ1 APOBEC3D ARPC2 ATG16L1 CARD9 DAP HSD17B1P1 IL1R1 KIF11 LRRC32 MIER1 PAPD5 PARK7 PDE4A PTRF RGS14 RP11-373D23.3 RTKN2 SLC22A5 UBE2L3
Waist Hip Ratio (WHR) 1.03 7 4 12.1 0.17 7.1e-01 AC010883.5 DLD FAM134C HSD17B1P1 NBEAL2 RP11-400F19.8 STAT5A
Systolic Blood Pressure 1.36 18 5 15.2 -0.01 9.6e-01 AC074117.10 ADCY3 ADO AGAP5 APEH ARPC2 CPSF3L ERAP2 FAM134C KIF11 RP11-297A16.2 RP11-373D23.3 SLC35E2 SMAD3 STMN3 TRAFD1 TSPAN14 UBE2L3
Smoking Status 1.36 2 1 3.0 0.00 1.0e+00 CPEB4 RTEL1
Allergy or Eczema 5.68 25 15 45.5 -0.67 1.2e-04 AC010733.5 AC010883.5 AC074117.10 ADAM15 AMZ1 CASC3 IGHEP2 KIAA1109 LRRC32 NAGLU NBEAL2 NDFIP1 PNMT PRKRIR PTGER4 RGS14 RP11-373D23.3 RP11-400F19.8 RTEL1 SMAD3 STAT5A STMN3 SULT1A1 TRAFD1 UBE2L3
Cardiovascular Disease 1.51 9 4 12.1 -0.47 2.0e-01 AC074117.10 ADO ATG16L1 NBEAL2 PMS2P5 RP11-373D23.3 SLC22A5 STMN3 TRAFD1
Hypothyroidism (self reported) 3.79 11 6 18.2 -0.36 2.5e-01 AC005104.3 AC010733.5 BRD7 GIGYF1 NRIP1 PAPD5 PTRF RNASET2 STAT5A TRAFD1 ZMIZ1
Respiratory disease 4.76 9 8 24.2 -0.35 3.3e-01 KIAA1109 KIF11 LRRC32 NDFIP1 PNMT PRKRIR RGS14 SLC22A5 SMAD3
Type 2 Diabetes (T2D) 2.33 5 3 9.1 0.69 2.0e-01 AC010883.5 AC074117.10 KIF11 PMS2P5 STMN3
Lung FEV1/FVC ratio 1.45 14 7 21.2 -0.38 1.8e-01 AC005104.3 AC010733.5 AC010883.5 ADCY3 ADO AMZ1 IL1R1 ITPKC PMS2P5 PNMT RGS14 SLC22A5 SMAD3 TSPAN14
Lung FVC 1.53 13 7 21.2 0.31 2.7e-01 AGAP5 APEH CARD9 GBAP1 HORMAD1 PARK7 PNMT RTEL1 SATB2 SLC22A5 SLC35E2 STMN3 SULT1A1
Chronotype (morning person) 1.26 1 1 3.0 0.00 1.0e+00 HORMAD1
Hair Pigment 0.30 11 8 24.2 -0.62 4.2e-02 AC010883.5 AC074117.10 ADAM15 ADCY3 CPSF3L GBAP1 GIGYF1 RP11-297A16.2 RP11-373D23.3 SYNGR1 ZNF831
Tanning 0.29 5 4 12.1 0.95 1.3e-02 AC074117.10 ADCY3 ADO HORMAD1 RP11-373D23.3
Hand grip strength (left) 1.16 1 1 3.0 0.00 1.0e+00 ADCY3
Number of treatments/medications taken 1.58 3 0 0.0 0.00 1.0e+00 AC074117.10 PMS2P5 TRAFD1
Average weekly spirits intake 1.21 1 0 0.0 0.00 1.0e+00 APEH
Hearing difficulty/problems: Yes 1.06 1 0 0.0 0.00 1.0e+00 SATB2
Relative age of first facial hair 1.05 2 0 0.0 0.00 1.0e+00 RP11-297A16.2 SATB2
Systolic blood pressure, automated reading 1.25 2 1 3.0 0.00 1.0e+00 ADO PMS2P5
Medication: Metformin 2.01 4 1 3.0 -0.85 1.5e-01 AC010883.5 AC074117.10 KIF11 PMS2P5
Diabetes (father) 1.74 1 1 3.0 0.00 1.0e+00 AC010883.5
Impedance of leg (right) 1.00 9 4 12.1 0.06 8.7e-01 AC010883.5 AC074117.10 ADCY3 GBAP1 NAGLU PMS2P5 RP11-400F19.8 SULT1A1 UBE2L3
Leg fat-free mass (left) 1.55 13 7 21.2 0.02 9.6e-01 AC005104.3 AC074117.10 ADO AMZ1 APEH GBAP1 PARK7 PDE4A RP11-400F19.8 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Trunk fat percentage 1.64 7 4 12.1 0.47 2.9e-01 ADCY3 AMZ1 APEH HORMAD1 RP11-400F19.8 RTEL1 SULT1A1
Hand grip strength (right) 1.21 2 1 3.0 0.00 1.0e+00 ADCY3 SLC22A5
Current tobacco smoking 1.45 2 2 6.1 0.00 1.0e+00 RTEL1 STMN3
Fed-up feelings 1.28 1 1 3.0 0.00 1.0e+00 APEH
Taking other prescription medications 2.00 2 0 0.0 0.00 1.0e+00 RNASET2 TRAFD1
Age when periods started (menarche) 1.58 4 3 9.1 -0.55 4.5e-01 ADCY3 APEH PMS2P5 SATB2
High blood pressure 1.13 3 2 6.1 0.00 1.0e+00 ADO PMS2P5 TRAFD1
Hayfever, allergic rhinitis or eczema 5.39 21 12 36.4 0.61 1.9e-03 AC010733.5 AC010883.5 AC074117.10 IGHEP2 KIAA1109 LRRC32 NAGLU NBEAL2 NDFIP1 PNMT PRKRIR PTGER4 RGS14 RP11-373D23.3 RP11-400F19.8 RTEL1 SLC22A5 SMAD3 STMN3 TRAFD1 UBE2L3
Medication: Atenolol 1.47 1 1 3.0 0.00 1.0e+00 TRAFD1
Medication: Levothyroxine sodium 2.87 6 2 6.1 0.44 3.9e-01 BRD7 CPSF3L GIGYF1 PTRF RNASET2 TRAFD1
Sitting height 1.62 12 7 21.2 -0.13 6.8e-01 AC074117.10 ADCY3 ADO AMZ1 ARPC2 CARD9 HSD17B1P1 IL1R1 MIER1 PARK7 RGS14 UBE2L3
Body mass index (BMI) 1.61 7 4 12.1 0.69 8.6e-02 ADCY3 APEH ARPC1B NAGLU PMS2P5 RP11-400F19.8 SULT1A1
Impedance of leg (left) 1.01 9 4 12.1 0.07 8.6e-01 AC010883.5 AC074117.10 ADCY3 GBAP1 NAGLU PMS2P5 RP11-400F19.8 SULT1A1 UBE2L3
Leg predicted mass (left) 1.55 12 7 21.2 0.07 8.3e-01 AC005104.3 AC074117.10 ADO AMZ1 APEH GBAP1 PARK7 PDE4A RP11-400F19.8 SLC22A5 SULT1A1 TRAFD1
Trunk fat mass 1.74 6 4 12.1 0.44 3.8e-01 ADCY3 AMZ1 APEH RP11-400F19.8 RTEL1 SULT1A1
Waist circumference 1.72 7 4 12.1 0.28 5.5e-01 ADCY3 AMZ1 APEH NAGLU RP11-400F19.8 SULT1A1 ZMIZ1
Past tobacco smoking 1.21 2 0 0.0 0.00 1.0e+00 ADAM15 GBAP1
Nervous feelings 1.00 1 0 0.0 0.00 1.0e+00 SATB2
Had menopause 1.49 1 1 3.0 0.00 1.0e+00 AC074117.10
Forced vital capacity (FVC) 1.30 9 6 18.2 -0.01 9.8e-01 AC005104.3 ADCY3 AMZ1 ARPC2 HORMAD1 RTEL1 SATB2 SLC35E2 STMN3
Qualifications: None of the above 0.93 2 2 6.1 0.00 1.0e+00 APEH SULT1A1
Mouth/teeth dental problems 1.54 2 1 3.0 0.00 1.0e+00 GBAP1 PMS2P5
Allergy 5.63 19 9 27.3 -0.50 2.5e-02 AC010733.5 AMZ1 IGHEP2 KIAA1109 KIF11 LRRC32 NAGLU NBEAL2 NDFIP1 PNMT PRKRIR RGS14 RP11-400F19.8 RTEL1 SLC22A5 SMAD3 STMN3 TRAFD1 UBE2L3
Diabetes (self-reported) 2.30 5 4 12.1 0.74 1.6e-01 AC010883.5 AC074117.10 KIF11 PMS2P5 RP11-400F19.8
Hayfever/allergic rhinitis (self-reported) 3.05 5 2 6.1 0.64 1.8e-01 KIAA1109 LRRC32 NAGLU PNMT SMAD3
Medication: Simvastatin 1.24 1 0 0.0 0.00 1.0e+00 AC074117.10
Fluid intelligence score 1.30 3 2 6.1 0.00 1.0e+00 APEH PAPD5 SULT1A1
Neuroticism score 0.94 1 0 0.0 0.00 1.0e+00 AC010883.5
Weight 1.72 12 6 18.2 0.25 4.3e-01 AC005104.3 AC074117.10 ADCY3 AMZ1 APEH GBAP1 PDE4A RP11-373D23.3 RP11-400F19.8 SLC22A5 SULT1A1 TRAFD1
Impedance of arm (right) 1.11 7 3 9.1 0.92 3.7e-03 AC074117.10 APEH LRRC32 SATB2 SLC35E2 SMAD3 TRAFD1
Arm fat percentage (right) 1.83 5 4 12.1 0.64 2.5e-01 ADCY3 AMZ1 APEH RP11-400F19.8 SULT1A1
Trunk fat-free mass 1.39 13 8 24.2 0.03 9.2e-01 AC005104.3 AC074117.10 ADO AMZ1 ARPC2 CARD9 PARK7 PDE4A RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Hip circumference 1.65 7 5 15.2 0.55 2.0e-01 ADCY3 AMZ1 APEH PDE4A RTEL1 SULT1A1 TRAFD1
Alcohol intake versus 10 years previously 1.16 2 1 3.0 0.00 1.0e+00 AC074117.10 APEH
Father's age at death 1.56 1 0 0.0 0.00 1.0e+00 APEH
Worrier / anxious feelings 0.99 1 0 0.0 0.00 1.0e+00 SATB2
Forced expiratory volume in 1-second (FEV1) 1.15 5 1 3.0 0.11 8.7e-01 ADCY3 APEH HORMAD1 SLC35E2 STMN3
Pulse rate 1.40 2 1 3.0 0.00 1.0e+00 AC074117.10 GIGYF1
Qualifications: A levels/AS levels or equivalent 1.23 2 1 3.0 0.00 1.0e+00 APEH SULT1A1
Mouth/teeth dental problems: Dentures 1.83 4 1 3.0 -0.47 5.3e-01 ADCY3 GBAP1 PMS2P5 PNMT
Asthma 4.82 8 8 24.2 0.33 3.8e-01 KIAA1109 KIF11 LRRC32 NDFIP1 PNMT PRKRIR SLC22A5 SMAD3
Medication: Cholesterol lowering 1.20 1 1 3.0 0.00 1.0e+00 AC074117.10
Forced expiratory volume in 1-second (FEV1), Best measure 1.07 4 0 0.0 -0.03 9.7e-01 ADCY3 ADO APEH STMN3
Impedance of arm (left) 1.11 8 4 12.1 0.92 1.1e-03 AC074117.10 AMZ1 APEH LRRC32 SATB2 SLC35E2 SMAD3 TRAFD1
Arm fat mass (right) 1.80 7 5 15.2 0.23 6.2e-01 ADCY3 AMZ1 APEH GBAP1 NAGLU RP11-400F19.8 SULT1A1
Trunk predicted mass 1.39 13 8 24.2 0.03 9.2e-01 AC005104.3 AC074117.10 ADO AMZ1 ARPC2 CARD9 PARK7 PDE4A RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Standing height 1.58 17 11 33.3 0.18 4.6e-01 AC005104.3 AC074117.10 ADCY3 ADO AMZ1 ARPC2 CARD9 HSD17B1P1 IL1R1 MIER1 PARK7 PDE4A PTRF RP11-373D23.3 SLC22A5 SULT1A1 UBE2L3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.26 1 0 0.0 0.00 1.0e+00 MIER1
Hair/balding pattern: Pattern 4 0.96 1 0 0.0 0.00 1.0e+00 RP3-434O14.8
Birth weight of first child 1.37 2 0 0.0 0.00 1.0e+00 TRAFD1 TSPAN14
Peak expiratory flow (PEF) 1.03 2 1 3.0 0.00 1.0e+00 AC010883.5 CPSF3L
Qualifications: O levels/GCSEs or equivalent 1.05 1 0 0.0 0.00 1.0e+00 APEH
Gout (self-reported) 1.69 2 1 3.0 0.00 1.0e+00 AC074117.10 GBAP1
Hypothyroidism/myxoedema (self-reported) 3.32 9 3 9.1 0.38 2.7e-01 BRD7 GIGYF1 NRIP1 PAPD5 PTRF RNASET2 STAT5A TRAFD1 ZMIZ1
Medication: Ventolin 100micrograms inhaler 2.59 6 1 3.0 0.43 3.9e-01 KIAA1109 LRRC32 NDFIP1 PNMT PRKRIR SMAD3
Birth weight 1.33 3 2 6.1 0.00 1.0e+00 AMZ1 KIF11 TRAFD1
Forced vital capacity (FVC), Best measure 1.17 7 4 12.1 -0.67 1.0e-01 AC005104.3 ADCY3 AMZ1 APEH HORMAD1 SATB2 STMN3
Body fat percentage 1.70 7 4 12.1 0.45 3.2e-01 ADCY3 AMZ1 APEH HORMAD1 RP11-400F19.8 RTEL1 SULT1A1
Leg fat percentage (right) 1.64 4 4 12.1 0.07 9.3e-01 ADCY3 APEH RTEL1 SULT1A1
Arm fat-free mass (right) 1.46 11 7 21.2 0.03 9.3e-01 AC005104.3 AC074117.10 AMZ1 APEH CARD9 PARK7 PDE4A RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1
Comparative body size at age 10 2.70 2 2 6.1 0.00 1.0e+00 ADCY3 SULT1A1
Wheeze or whistling in the chest in last year 2.32 7 4 12.1 0.20 6.6e-01 APEH KIAA1109 LRRC32 PNMT PRKRIR RTEL1 SMAD3
Age at first live birth 1.12 1 0 0.0 0.00 1.0e+00 APEH
Shortness of breath walking on level ground 1.50 1 0 0.0 0.00 1.0e+00 LRRC32
Qualifications: College or University degree 1.57 4 2 6.1 0.98 2.3e-02 APEH RTEL1 STMN3 SULT1A1
Medication: Allopurinol 1.51 1 1 3.0 0.00 1.0e+00 AC074117.10
Mean time to correctly identify matches 1.00 1 0 0.0 0.00 1.0e+00 ADCY3
Whole body fat mass 1.79 6 4 12.1 0.43 3.9e-01 ADCY3 AMZ1 APEH RP11-400F19.8 RTEL1 SULT1A1
Leg fat mass (right) 1.74 7 4 12.1 0.42 3.5e-01 ADCY3 AMZ1 APEH PMS2P5 RP11-400F19.8 RTEL1 SULT1A1
Arm predicted mass (right) 1.52 13 9 27.3 -0.01 9.8e-01 AC005104.3 AC074117.10 AMZ1 APEH CARD9 PARK7 PDE4A RP11-373D23.3 SLC22A5 SULT1A1 SYNGR1 TRAFD1 ZMIZ1
Pulse rate, automated reading 1.80 3 2 6.1 0.00 1.0e+00 AC074117.10 AGAP5 GIGYF1
Alcohol intake frequency. 1.53 5 2 6.1 0.31 6.2e-01 AC074117.10 APEH PMS2P5 RP11-400F19.8 SULT1A1
Comparative height size at age 10 1.52 12 10 30.3 0.25 3.8e-01 AC005104.3 AC010883.5 AC074117.10 ADCY3 AMZ1 ARPC2 CARD9 KIF11 SLC22A5 SULT1A1 TRAFD1 UBE2L3
Suffer from 'nerves' 1.05 2 1 3.0 0.00 1.0e+00 SATB2 SULT1A1
Overall health rating 1.21 2 1 3.0 0.00 1.0e+00 APEH PMS2P5
Age at last live birth 1.02 1 0 0.0 0.00 1.0e+00 APEH
Hypertension (Self-reported) 1.03 3 2 6.1 0.00 1.0e+00 ADO PMS2P5 TRAFD1
Illnesses of father: Heart disease 1.46 1 0 0.0 0.00 1.0e+00 SMAD3
Smoking status: Previous 1.21 1 0 0.0 0.00 1.0e+00 GBAP1
Forced expiratory volume in 1-second (FEV1), predicted 1.18 2 1 3.0 0.00 1.0e+00 AMZ1 PDE4A
Whole body fat-free mass 1.46 14 8 24.2 0.06 8.5e-01 AC005104.3 AC074117.10 ADO AMZ1 ARPC2 CARD9 GBAP1 PARK7 PDE4A RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Leg fat-free mass (right) 1.51 11 7 21.2 0.18 5.9e-01 AC005104.3 AC074117.10 ADO AMZ1 GBAP1 PARK7 PDE4A RP11-400F19.8 SLC22A5 SULT1A1 TRAFD1
Arm fat percentage (left) 1.82 6 5 15.2 0.64 1.7e-01 ADCY3 AMZ1 APEH PMS2P5 RP11-400F19.8 SULT1A1
Mood swings 1.24 1 0 0.0 0.00 1.0e+00 APEH
Long-standing illness, disability or infirmity 1.74 1 0 0.0 0.00 1.0e+00 PMS2P5
Diabetes diagnosed by doctor 2.32 5 3 9.1 -0.21 7.4e-01 AC010883.5 AC074117.10 KIF11 PMS2P5 RP11-400F19.8
Qualifications: nursing, teaching 0.82 1 0 0.0 0.00 1.0e+00 APEH
Mouth/teeth dental problems: Mouth ulcers 2.41 4 0 0.0 0.48 5.2e-01 BRD7 IL12B PNMT TNFSF15
Medication for cholesterol 1.20 1 0 0.0 0.00 1.0e+00 TRAFD1
Asthma (self-reported) 4.81 10 8 24.2 0.32 3.3e-01 KIAA1109 KIF11 LRRC32 NAGLU NDFIP1 PNMT PRKRIR RP11-400F19.8 SLC22A5 SMAD3
Smoking status: Current 1.40 2 0 0.0 0.00 1.0e+00 RTEL1 STMN3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.19 3 1 3.0 0.00 1.0e+00 AMZ1 PNMT STMN3
Whole body water mass 1.45 14 8 24.2 0.05 8.6e-01 AC005104.3 AC074117.10 ADO AMZ1 ARPC2 CARD9 GBAP1 PARK7 PDE4A RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Leg predicted mass (right) 1.51 12 7 21.2 0.12 7.0e-01 AC005104.3 AC074117.10 ADO AMZ1 GBAP1 PARK7 PDE4A RP11-373D23.3 RP11-400F19.8 SLC22A5 SULT1A1 TRAFD1
Arm fat mass (left) 1.80 7 5 15.2 0.23 6.2e-01 ADCY3 AMZ1 APEH GBAP1 NAGLU RP11-400F19.8 SULT1A1
Number of self-reported non-cancer illnesses 1.96 5 1 3.0 0.64 2.4e-01 AC074117.10 LRRC32 PMS2P5 STMN3 TRAFD1
Miserableness 1.08 1 1 3.0 0.00 1.0e+00 APEH
Medication: Blood pressure 1.14 1 0 0.0 0.00 1.0e+00 TRAFD1
High cholesterol (Self-reported) 1.53 1 1 3.0 0.00 1.0e+00 AC074117.10
Medication: Atorvastatin 1.60 1 1 3.0 0.00 1.0e+00 AC074117.10
Ever smoked 1.30 1 0 0.0 0.00 1.0e+00 ADAM15
Basal metabolic rate 1.53 15 8 24.2 -0.02 9.5e-01 AC005104.3 AC074117.10 ADO AMZ1 APEH CARD9 GBAP1 PARK7 PDE4A RP11-373D23.3 RP11-400F19.8 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Leg fat percentage (left) 1.65 4 4 12.1 0.13 8.7e-01 ADCY3 APEH RTEL1 SULT1A1
Arm fat-free mass (left) 1.48 12 9 27.3 -0.03 9.3e-01 AC005104.3 AC074117.10 AMZ1 APEH CARD9 PARK7 PDE4A RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Number of operations (self-reported) 1.45 3 1 3.0 0.00 1.0e+00 AMZ1 MTMR3 PARK7
Irritability 1.09 2 0 0.0 0.00 1.0e+00 AC010883.5 ERAP2
Diastolic blood pressure, automated reading 1.52 9 6 18.2 0.28 4.7e-01 ADAM15 ADO APEH ERAP2 GIGYF1 PMS2P5 RTEL1 STMN3 TRAFD1
Vascular/heart problems diagnosed by doctor 1.17 4 2 6.1 0.18 8.2e-01 ADO PMS2P5 SLC22A5 TRAFD1
Cholesterol lowering medication 1.44 1 1 3.0 0.00 1.0e+00 AC074117.10
Pain experienced in last month 1.35 1 0 0.0 0.00 1.0e+00 APEH
Impedance of whole body 0.99 9 3 9.1 0.65 5.6e-02 AC010883.5 AC074117.10 ADCY3 APEH NAGLU PMS2P5 SATB2 SLC35E2 ZMIZ1
Leg fat mass (left) 1.74 6 4 12.1 0.42 4.1e-01 ADCY3 AMZ1 APEH RP11-400F19.8 RTEL1 SULT1A1
Arm predicted mass (left) 1.48 13 7 21.2 -0.09 7.8e-01 AC005104.3 AC074117.10 AMZ1 APEH ARPC2 CARD9 PARK7 PDE4A RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 36 1.032 2.36
GTEx Adipose Visceral Omentum 23 1.130 2.46
GTEx Adrenal Gland 19 1.306 2.43
GTEx Artery Aorta 31 1.042 2.35
GTEx Artery Coronary 17 1.438 2.49
GTEx Artery Tibial 41 1.091 2.43
GTEx Brain Caudate basal ganglia 12 1.302 2.41
GTEx Brain Cerebellar Hemisphere 22 1.477 2.57
GTEx Brain Cerebellum 24 1.210 2.47
GTEx Brain Cortex 19 1.836 2.54
GTEx Brain Frontal Cortex BA9 12 1.297 2.50
GTEx Brain Hippocampus 7 1.333 2.37
GTEx Brain Hypothalamus 8 1.354 2.62
GTEx Brain Nucleus accumbens basal ganglia 12 1.386 2.43
GTEx Brain Putamen basal ganglia 10 1.600 2.55
GTEx Breast Mammary Tissue 23 1.168 2.32
GTEx Breast Mammary Tissue (Male) 11 0.923 2.34
GTEx Breast Mammary Tissue (Female) 17 1.037 2.39
GTEx Cells EBV-transformed lymphocytes 12 0.844 2.47
GTEx Cells Transformed fibroblasts 42 1.000 2.36
GTEx Colon Sigmoid 18 1.231 2.46
GTEx Colon Transverse 26 1.261 2.42
GTEx Esophagus Gastroesophageal Junction 25 1.729 2.52
GTEx Esophagus Mucosa 40 1.205 2.66
GTEx Esophagus Muscularis 32 0.991 2.42
GTEx Heart Atrial Appendage 22 1.392 2.60
GTEx Heart Left Ventricle 18 1.175 2.32
GTEx Liver 7 0.979 2.25
GTEx Lung 45 1.568 2.61
GTEx Muscle Skeletal 26 0.901 2.35
GTEx Nerve Tibial 50 1.157 2.44
GTEx Ovary 17 1.868 2.77
GTEx Pancreas 14 0.858 2.30
GTEx Pituitary 19 1.706 2.54
GTEx Prostate 16 1.925 2.74
GTEx Skin Not Sun Exposed Suprapubic 32 1.303 2.53
GTEx Skin Sun Exposed Lower leg 41 1.128 2.51
GTEx Small Intestine Terminal Ileum 5 1.089 2.19
GTEx Spleen 21 1.489 2.73
GTEx Stomach 18 1.239 2.57
GTEx Testis 37 1.173 2.39
GTEx Thyroid 45 1.127 2.44
GTEx Uterus 8 1.411 2.54
GTEx Vagina 14 2.205 2.69
GTEx Whole Blood 36 1.807 2.98
METSIM Adipose 52 1.129 2.43
NTR Blood 34 1.414 2.77
ROSMAP Brain Pre-frontal Cortex 42 0.957 2.22
YFS Blood 44 0.953 2.45
CommonMind Brain Pre-frontal Cortex 44 0.819 2.18
TCGA Breast Tumor 8 1.044 2.20
TCGA Breast Normal 28 0.665 1.99
TCGA Ovarian Tumor 18 0.616 2.02
TCGA Prostate Tumor 40 1.157 2.27