TWAS hub - ZCCHC14

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0443	0.0163	0.00054	0.018	0.016	0.029	0.016	0.029	0.00093	0.0015	2.9e-05	0.0015	2.9e-05
2	TCGA	Esophageal Carcinoma	0.0980	0.0560	0.00690	0.092	0.068	0.054	NA	0.084	0.00074	0.0034	8.5e-03	NA	1.3e-03
3	TCGA	Testicular Germ Cell Tumors	0.2500	0.0890	0.00120	0.081	0.038	0.017	NA	0.021	0.00082	0.0170	7.8e-02	NA	6.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Birth weight	5.3	11.4	26.7	5.2	-0.1	2.7
Bipolar Disorder (2018)	4.4	7.0	16.1	1.0	-4.0	2.0
Tense / ‘highly strung’	4.1	6.8	13.8	-0.3	-3.7	2.5
Mean time to correctly identify matches	4.0	7.7	10.7	-3.3	-1.3	-3.3
Reaction Time	3.8	7.3	13.1	-3.6	-0.8	-2.8
Mood swings	3.5	6.3	17.0	-0.9	-4.1	-1.1
Worry (Nagel 2018)	3.4	7.1	18.2	-0.0	-4.3	1.8
Sensitivity / hurt feelings	3.3	5.6	15.2	-0.7	-3.9	1.0
Medication: Lansoprazole	3.0	3.4	8.0	-0.6	-1.4	2.8
Major Depression (MDD)	2.9	3.5	4.3	1.5	-2.0	2.1
Lung FVC	2.9	14.9	31.7	-2.0	-3.0	5.6
Chronic bronchitis/emphysema (father)	2.9	3.4	6.9	-2.6	-1.8	0.3
Bipolar Disorder or Schizophrenia	2.6	6.4	16.3	-0.1	-4.0	1.7
Neuroticism (Nagel 2018)	2.6	6.1	18.1	-0.2	-4.2	0.5
Diabetes (father)	2.6	3.2	8.1	0.3	2.9	-1.2
Average weekly red wine intake	2.6	3.8	8.4	-0.8	2.9	-1.5
Commuting to job workplace: Cycle	2.6	3.1	7.9	-0.2	2.8	-1.2
Neuroticism	2.5	6.0	16.8	-0.2	-4.1	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.4	5.2	-0.1	-2.2	2.3
Cholesterol lowering medication	2.5	3.7	6.9	-1.2	1.6	-2.6
Neuroticism (2016)	2.4	3.5	9.3	-0.6	-3.0	1.0
Smoking Status	2.4	5.8	9.4	-3.1	-2.8	0.2
Trunk fat percentage	2.4	9.7	18.9	2.7	4.3	-1.7
Comparative body size at age 10	2.4	6.5	12.9	-1.9	-3.6	1.8
Smoking status: Current	2.4	3.8	9.1	-3.0	-1.2	-1.0
Wears glasses or contact lenses	2.4	2.8	4.2	0.3	2.0	-2.0
Supplements: Calcium	2.4	2.7	6.1	2.5	1.3	0.6
Relative age of first facial hair	2.3	4.6	8.2	2.1	2.9	1.1
Smoking status: Previous	2.3	3.4	6.9	0.2	-2.6	1.8
Past tobacco smoking	2.2	4.0	10.0	0.6	3.2	-1.3
Medication: Simvastatin	2.2	3.2	5.6	0.1	2.4	-2.0
Current tobacco smoking	2.1	3.5	7.5	-2.7	-1.4	-1.0
Irritability	2.1	3.6	9.8	-0.3	-3.1	1.0
Trunk fat mass	2.0	8.6	14.4	3.1	3.8	-1.4
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	3.9	-1.6	-2.0	-1.0
Body fat percentage	2.0	7.8	15.8	2.1	4.0	-1.8
Schizophrenia (2014)	1.9	4.2	11.6	-0.6	-3.4	0.9
Supplements: Zinc	1.9	2.0	2.9	1.7	-1.6	0.7
Noisy workplace	1.9	2.4	4.9	-1.2	-2.2	0.8
Supplements: Vitamin C	1.9	2.2	4.3	0.7	-2.1	1.4
Age started oral contraceptive pill	1.9	2.3	3.3	-0.9	1.8	-1.7
Alzheimer’s Disease (in father)	1.8	1.9	5.2	0.8	-0.0	2.3
Worry too long after embarrassment	1.8	3.1	5.8	1.0	-2.4	1.5
Qualifications: College or University degree	1.8	5.6	14.8	1.4	3.8	0.1
Had major operations	1.8	2.1	2.9	-1.0	1.7	-1.6
Medication: Aspirin	1.8	2.4	4.6	-1.5	0.7	-2.1
Financial situation satisfaction	1.8	2.2	5.0	-1.2	-2.2	-0.3
High cholesterol (Self-reported)	1.8	3.2	4.8	0.7	2.2	-2.0
Stomach or abdominal pain in last month	1.7	2.2	3.6	1.2	-1.2	1.9
Sitting height	1.7	12.1	24.9	5.0	3.2	0.9
Nervous feelings	1.7	3.2	8.6	-0.2	-2.9	1.0
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	6.0	-1.2	-2.4	0.5
Peak expiratory flow (PEF)	1.7	4.0	7.7	1.8	2.8	0.9
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	6.5	1.3	2.6	-0.2
Shortness of breath walking on level ground	1.7	2.0	3.4	-1.9	-1.4	-0.7
Illnesses of siblings	1.6	2.2	5.7	2.4	-0.9	0.3
Neuroticism score	1.6	3.3	9.9	-0.2	-3.2	0.3
Prospective memory result	1.6	2.0	5.6	0.4	-2.4	0.5
Glaucoma (self-reported)	1.6	1.9	3.5	1.3	1.9	0.8
Age at first live birth	1.6	2.8	7.4	-2.7	-0.7	0.6
Whole body fat mass	1.6	6.7	10.9	2.7	3.3	-1.5
Suffer from ‘nerves’	1.6	2.5	7.1	0.2	-2.7	0.5
Leg pain on walking	1.6	1.9	4.1	0.7	-2.0	1.1
Eye problems/disorders: Glaucoma	1.6	1.8	4.7	0.9	2.2	0.1
Vascular/heart problems diagnosed by doctor	1.6	4.2	8.2	0.2	-2.1	2.9
Depression (Nagel 2018)	1.5	2.2	5.0	-1.0	-2.2	0.8
Ovarian Cancer	1.5	2.0	3.3	1.8	0.2	1.6
Mean Putamen Volume	1.5	1.7	3.8	-0.2	-2.0	1.1
Cardiovascular Disease	1.5	5.0	10.5	0.6	3.2	-2.0
Maternal smoking around birth	1.5	2.2	5.8	-0.4	-2.4	0.9
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.6	-0.9	-0.6	1.9
Qualifications: None of the above	1.5	3.3	5.7	-2.0	-2.4	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	4.5	1.1	-2.1	0.3
Number of children fathered	1.5	1.7	4.5	-2.1	-0.0	0.8
Ever smoked	1.5	2.6	6.6	-0.9	-2.6	0.6
Heart attack/myocardial infarction (self-reported)	1.5	2.0	3.3	0.2	1.6	-1.8
Intelligence (Savage-Jansen 2018)	1.4	4.3	9.7	1.8	3.1	-0.1
Had other major operations	1.4	1.7	2.4	0.9	1.6	-1.4
Lung cancer (father)	1.4	1.7	4.4	0.2	-0.8	2.1
Exposure to tobacco smoke at home	1.4	1.5	3.5	-0.1	1.0	-1.9
Emphysema/chronic bronchitis	1.4	1.6	3.2	-0.2	-1.3	1.8
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	3.1	-1.6	1.7	-1.0
Leg fat percentage (left)	1.4	5.1	11.0	0.3	3.3	-2.1
Ever had hysterectomy (womb removed)	1.3	1.4	2.2	1.3	-0.7	1.5
High blood pressure	1.3	3.5	7.0	-0.2	1.9	-2.6
Number of incorrect matches in round	1.3	2.2	3.8	-1.9	-1.0	-1.4
Heart attack	1.3	1.7	3.2	-0.1	1.4	-1.8
Hip circumference	1.3	5.8	12.7	1.8	3.6	-1.2
Impedance of arm (left)	1.3	5.8	11.0	2.5	3.3	-0.1
Ever highly irritable/argumentative for 2 days	1.3	1.6	4.5	0.3	-2.1	-0.4
Number of full brothers	1.3	1.7	4.3	-0.6	0.6	2.1
Hypertension (Self-reported)	1.3	3.5	7.0	0.0	1.9	-2.6
Back pain experienced in last month	1.3	1.9	3.9	-0.6	-1.1	2.0
Osteoporosis (self-reported)	1.3	1.6	3.7	-0.5	1.0	1.9
Coronary Artery Disease (CAD)	1.2	1.4	1.8	-1.2	-1.3	-1.0
Hearing difficulty/problems with background noise	1.2	1.9	3.1	1.8	1.6	-0.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	1.9	1.4	-1.2	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.2	-0.5	-1.8	1.6
Leg fat percentage (right)	1.2	4.3	8.9	0.4	3.0	-2.0
Comparative height size at age 10	1.2	6.5	8.6	2.8	2.9	-1.7
Arm fat percentage (left)	1.2	4.6	10.2	1.7	3.2	-0.9
Hearing aid user	1.2	1.3	3.7	-1.9	0.4	-0.4
Fractured/broken bones in last 5 years	1.2	1.6	4.0	-0.6	2.0	0.7
Myopia	1.2	1.8	2.3	0.9	-1.5	1.5
LDL Cholesterol	1.1	1.7	2.5	1.6	1.5	0.7
Frequency of depressed mood in last 2 weeks	1.1	1.6	4.7	-2.2	-0.2	-0.4
Impedance of leg (left)	1.1	5.2	10.2	0.8	3.2	-2.2
Standing height	1.1	10.5	27.5	5.2	2.0	0.2
Family relationship satisfaction	1.1	1.4	2.3	-1.3	1.5	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	4.1	-2.0	-0.5	-0.3
Heart disease (siblings)	1.1	1.4	2.6	-1.6	0.3	1.2
Leg fat mass (left)	1.1	4.3	8.1	1.7	2.9	-1.4
Number of treatments/medications taken	1.0	1.9	3.7	-1.2	0.7	-1.9
Medication: Co-codamol	1.0	1.2	1.6	1.1	1.3	-0.9
Severe depression (siblings)	1.0	1.1	1.4	-1.1	-1.2	-0.9
Medication: Ramipril	1.0	1.2	2.3	0.1	1.2	-1.5
Impedance of arm (right)	1.0	4.5	8.4	2.2	2.9	-0.0
Arm fat percentage (right)	1.0	3.9	8.6	1.6	2.9	-0.9
Hair/balding pattern: Pattern 3	1.0	1.4	3.5	-0.6	-1.9	-0.7
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	10.2	-0.0	-0.1	3.2
Happiness	1.0	1.2	2.7	-1.6	-0.7	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	9.4	-0.1	-0.1	3.1
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.2	-0.6	-1.8	-0.1
Age at last live birth	1.0	1.4	3.5	-1.9	0.6	-0.6
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.3	-0.3	-1.8	-0.4
Medication: Aspirin	1.0	1.4	2.7	-0.7	0.9	-1.7
Illnesses of siblings: Diabetes	1.0	1.3	3.2	-0.3	1.8	-0.7
Average weekly champagne plus white wine intake	1.0	1.4	2.7	1.2	-1.7	0.2
Guilty feelings	1.0	1.5	1.9	-1.4	-1.4	-0.8
Commuting to job workplace: Public transport	1.0	1.2	3.0	0.1	1.7	-0.7
Impedance of whole body	1.0	5.3	10.6	1.9	3.3	-1.3
HbA1C	0.9	1.0	1.7	-1.1	-0.3	1.3
Heel T-Score	0.9	6.9	18.7	-1.4	-4.3	0.3
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.8	-0.2	-0.8	-1.7
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.9	-0.4	0.1	-1.7
Medication: Metformin	0.9	1.3	2.2	0.9	1.5	-0.9
Townsend deprivation index at recruitment	0.9	1.2	2.6	0.9	1.6	0.5
Weight	0.9	4.3	7.2	2.7	2.3	-0.6
Worrier / anxious feelings	0.9	1.7	4.2	0.4	-2.1	0.8
Arm fat mass (right)	0.9	3.6	6.6	1.8	2.6	-1.1
Blood clot in the leg (DVT)	0.9	1.1	3.0	-1.7	-0.5	-0.2
Forced vital capacity (FVC), Best measure	0.9	3.3	9.1	0.4	-0.9	3.0
Wheeze or whistling in the chest in last year	0.9	1.6	2.0	-1.3	-1.0	-1.4
Medication for pain relief, constipation, heartburn	0.9	1.6	3.1	1.8	0.8	1.0
Medication: Blood pressure	0.9	1.6	2.0	-1.4	1.0	-1.4
Medication: Ibuprofen	0.9	1.1	1.6	-1.2	-0.6	-1.3
Medication: Omeprazole	0.9	1.0	2.9	-0.3	0.4	-1.7
Medication: Seretide 50 evohaler	0.9	1.0	2.7	1.6	0.3	-0.5
Leg fat mass (right)	0.9	3.7	6.7	1.6	2.6	-1.3
Number of full sisters	0.9	1.0	1.6	1.2	1.3	-0.2
Illnesses of father: Heart disease	0.9	1.2	3.6	-0.3	0.1	-1.9
Breast cancer (self-reported)	0.9	1.1	2.0	1.0	1.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	3.9	-2.0	0.1	1.4
Arm fat mass (left)	0.9	3.7	7.3	1.8	2.7	-0.9
Medication: Blood pressure	0.9	1.7	2.6	-0.1	1.6	-1.6
Average weekly beer plus cider intake	0.9	1.3	3.5	-1.9	0.4	-0.4
Pack years of smoking	0.9	1.4	2.7	-1.0	-0.7	-1.6
Schizophrenia (2018)	0.8	1.7	4.0	-0.9	-2.0	0.5
Verbal and Numeric Reasoning (VNR)	0.8	1.9	2.9	1.5	1.7	0.6
Blood White Count	0.8	6.3	11.0	-1.8	2.2	-3.3
Impedance of leg (right)	0.8	4.0	7.6	0.9	2.8	-1.9
Relative age voice broke	0.8	1.2	2.5	1.6	0.9	0.6
Waist circumference	0.8	3.0	5.1	1.1	2.3	-1.6
Forced vital capacity (FVC)	0.8	3.2	8.4	0.2	-1.1	2.9
Exposure to tobacco smoke outside home	0.8	1.0	2.0	-0.9	-0.5	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.0	-1.4	-0.7	-0.5
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.4	1.2	1.2	-0.0
Medication: Lisinopril	0.8	1.1	2.2	-1.1	1.5	-0.0
Height	0.7	12.7	35.4	6.0	1.5	-0.5
Respiratory disease	0.7	1.6	2.8	-1.7	-1.4	-0.1
Average weekly fortified wine intake	0.7	0.8	1.0	1.0	1.0	-0.6
Age when periods started (menarche)	0.7	1.8	5.1	-0.4	0.2	-2.2
Serious illness, injury or assault to yourself	0.7	0.9	2.2	-0.5	0.6	-1.5
Pain all over the body in last month	0.7	0.7	1.5	0.8	1.2	-0.0
Diabetes (self-reported)	0.7	1.0	1.9	0.5	1.4	-0.9
Fluid intelligence score	0.7	1.5	3.6	1.9	0.9	0.4
Father’s age at death	0.7	0.9	1.0	1.0	1.0	-1.0
Length of working week for main job	0.7	0.8	2.3	-0.3	0.1	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.6	0.7	-1.6	0.3
Hair/balding pattern: Pattern 4	0.7	1.8	4.7	-0.1	0.8	-2.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.4	0.8	-1.1	1.2
High blood pressure (siblings)	0.7	1.0	2.1	-1.5	0.8	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.4	1.2	-0.4	-0.9
Knee pain experienced in last month	0.7	1.1	3.0	0.4	-1.7	0.3
Eye problems/disorders: Cataract	0.7	0.8	1.7	0.1	-1.3	0.8
Medication for cholesterol	0.7	1.1	2.4	-0.3	-0.9	1.6
Number of self-reported non-cancer illnesses	0.7	1.1	2.4	0.8	1.5	-0.6
Ever taken oral contraceptive pill	0.7	0.8	1.9	-0.2	-0.6	-1.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.3	-1.1	-1.1	-0.4
Medication: Bendroflumethiazide	0.7	1.0	3.0	-0.2	1.7	-0.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.8	0.7	-0.1	-1.3
Diastolic blood pressure, automated reading	0.7	2.2	3.8	1.6	1.9	0.7
Pain experienced in last month	0.7	1.2	3.4	0.2	1.8	-0.3
Depressed Affect (Nagel 2018)	0.6	1.2	2.2	-0.0	-1.5	-1.2
Alzheimer’s Disease (in mother)	0.6	0.7	1.1	0.2	1.0	-1.0
HDL Cholesterol	0.6	1.0	2.2	-1.5	-0.7	-0.6
Triglycerides	0.6	0.9	2.7	1.6	-0.1	0.3
Pack years adult smoking proportion	0.6	1.0	1.7	-1.0	-0.5	-1.3
Leg fat-free mass (left)	0.6	2.9	8.4	2.9	0.4	0.5
Hand grip strength (right)	0.6	1.6	3.3	1.2	-1.8	0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.0	1.0	0.7	0.7
Leg predicted mass (left)	0.6	3.0	8.7	3.0	0.3	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	1.1	-1.1	0.1	-0.9
Medication: Cholesterol lowering	0.6	0.9	1.6	0.7	1.3	-0.9
Breastfed as a baby	0.6	0.8	1.4	1.2	-0.2	0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.9	-1.4	-0.4	-0.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.4	-1.2	-0.8	0.4
Eye problems/disorders: None of the above	0.6	0.7	1.0	-1.0	-1.0	-0.3
Migraine (self-reported)	0.6	0.8	2.2	-0.4	-1.5	0.2
Qualifications: nursing, teaching	0.6	0.9	2.5	0.6	1.6	0.1
Risk taking	0.6	0.9	2.1	1.5	-0.3	0.7
Basal cell carcinoma (self-reported)	0.6	0.8	1.0	-0.9	1.0	-0.6
Tanning	0.5	6.3	17.9	1.0	-4.2	0.1
Hand grip strength (left)	0.5	1.4	4.0	0.2	-2.0	0.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.7	1.3	0.4	-0.2
Medication for hormone replacement therapy	0.5	0.6	1.1	-0.2	-0.8	-1.1
Vitamin and mineral supplements	0.5	0.7	1.8	-1.4	0.4	-0.2
Multivitamins +/- minerals	0.5	0.6	0.9	0.9	0.7	-0.8
Falls in the last year	0.5	0.6	1.5	1.2	-0.1	0.6
Number of live births	0.5	0.7	1.5	1.2	0.5	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.2	0.3	1.8	0.2
Angina (self-reported)	0.5	0.7	1.2	-1.1	0.6	-0.6
Overall health rating	0.5	1.0	1.8	1.4	1.1	0.1
Ever had bowel cancer screening	0.5	0.6	1.0	0.8	-0.5	1.0
Diabetes diagnosed by doctor	0.5	0.8	1.5	0.6	1.2	-0.7
Osteoarthritis (self-reported)	0.5	0.7	2.0	0.3	-1.4	0.0
Leg predicted mass (right)	0.5	2.5	7.1	2.7	0.4	0.6
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.0	1.4	0.3	0.0
Alcohol drinker status: Previous	0.5	0.6	1.6	1.3	0.2	0.5
Ulcerative Colitis (UC)	0.4	0.8	1.2	0.8	-0.6	1.1
Age at First Birth	0.4	0.6	0.9	-0.9	-0.3	0.8
Crohns Disease (2012)	0.4	0.6	1.6	0.4	-1.3	-0.3
BMI	0.4	2.3	4.2	0.1	2.1	-1.6
Systolic Blood Pressure	0.4	2.1	2.4	-1.6	1.6	-1.1
Lung FEV1/FVC ratio	0.4	1.9	3.9	-1.1	2.0	0.8
Medication: Atenolol	0.4	0.5	0.6	-0.7	-0.5	0.8
Mouth/teeth dental problems	0.4	0.6	0.9	0.9	0.8	0.6
Medication: Amlodipine	0.4	0.6	1.0	1.0	-0.7	-0.7
Health satisfaction	0.4	0.5	1.1	-0.5	0.3	-1.0
Neck or shoulder pain in last month	0.4	0.5	1.2	0.4	-1.1	0.5
Arm predicted mass (right)	0.4	1.8	5.5	2.3	-0.1	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	-1.1	0.5	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.4	1.6	0.0	-0.1
Whole body fat-free mass	0.4	2.0	6.0	2.4	-0.0	0.2
Leg fat-free mass (right)	0.4	2.4	6.8	2.6	0.4	0.5
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-0.5	1.0	-0.1
Medication: Gliclazide	0.4	0.5	1.1	1.0	0.5	-0.3
Illnesses of father: High blood pressure	0.4	0.4	1.0	0.1	0.6	-1.0
Basal metabolic rate	0.4	2.5	6.9	2.6	0.8	0.0
Crohns Disease (2017)	0.3	0.7	1.8	1.3	-0.0	-0.4
Irritable Bowel Disease (IBD)	0.3	0.7	1.7	1.3	-0.1	0.6
Prostate Cancer	0.3	0.4	0.9	1.0	0.3	0.5
Lupus	0.3	0.4	0.8	0.7	-0.9	-0.3
Primary Biliary Cirrhosis	0.3	0.4	0.6	-0.7	-0.8	-0.2
Rheumatoid Arthritis	0.3	0.5	1.1	0.5	-0.1	-1.1
Blood Platelet Count	0.3	3.8	6.2	-2.2	0.1	-2.5
Chronotype (morning person)	0.3	0.7	1.3	-0.1	-1.1	0.9
Systolic blood pressure, automated reading	0.3	0.9	2.0	-1.4	0.3	-0.8
Angina	0.3	0.3	0.5	-0.7	0.6	-0.4
Qualifications: CSEs or equivalent	0.3	0.3	1.0	1.0	0.1	-0.3
Supplements: Glucosamine	0.3	0.4	1.1	0.2	0.2	-1.0
Medication: Levothyroxine sodium	0.3	0.6	1.3	-1.2	-0.2	-0.6
Alcohol usually taken with meals	0.3	0.5	1.1	0.1	0.6	-1.0
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	-0.3	-1.0	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.2	-0.8	-1.1	-0.2
Financial difficulties in last 2 years	0.3	0.4	1.1	-0.0	-1.1	-0.1
Trunk fat-free mass	0.3	1.8	5.0	2.2	-0.3	0.4
Asthma	0.3	0.7	0.9	-0.7	-0.9	-0.8
Illnesses of mother	0.3	0.3	0.9	0.9	0.1	-0.3
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	0.5	0.9	0.3
Trunk predicted mass	0.3	1.8	5.0	2.2	-0.3	0.4
Birth weight of first child	0.3	0.6	1.3	1.1	0.8	0.1
Pulse wave reflection index	0.3	0.4	1.1	0.1	0.4	1.0
Loud music exposure frequency	0.3	0.3	0.5	0.4	-0.5	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.4	-0.9	-0.3
Arm fat-free mass (right)	0.3	1.3	3.9	2.0	0.1	-0.3
Heart disease (mother)	0.3	0.4	0.5	-0.7	-0.3	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.7	-0.1	-0.8	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	-0.0	-1.0	0.4
Mineral and other dietary supplements	0.3	0.4	0.5	-0.7	-0.7	-0.3
Asthma (self-reported)	0.3	0.6	0.8	-0.5	-0.9	-0.8
Whole body water mass	0.3	2.0	5.9	2.4	0.1	0.3
Number of operations (self-reported)	0.3	0.5	1.3	0.3	1.2	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.4	0.4	0.5	0.6
Breast Cancer	0.2	0.4	0.7	0.1	-0.8	-0.7
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	0.7	0.5	0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.2	0.7	0.4
Ulcerative Colitis	0.2	0.2	0.4	0.5	-0.2	0.6
Allergy or Eczema	0.2	0.6	1.2	-0.7	-1.1	0.2
Hypothyroidism (self reported)	0.2	0.5	0.7	-0.1	-0.9	0.8
Average weekly spirits intake	0.2	0.3	0.4	0.3	-0.7	-0.6
Fed-up feelings	0.2	0.3	0.5	0.6	0.2	-0.7
Taking other prescription medications	0.2	0.4	1.0	-0.1	1.0	-0.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	-0.8	0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	0.7	-0.4	-0.5	-0.8
Body mass index (BMI)	0.2	1.1	2.5	0.4	1.6	-0.7
Allergy	0.2	0.5	1.0	0.5	1.0	-0.7
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.1	-0.8	0.4
Pulse rate	0.2	0.3	0.8	0.2	0.2	-0.9
Mouth/teeth dental problems: Dentures	0.2	0.4	1.2	-0.2	-0.2	-1.1
Depression (self-reported)	0.2	0.2	0.6	0.0	-0.4	-0.7
Medication: Paracetamol	0.2	0.3	0.5	0.3	0.7	-0.6
Gout (self-reported)	0.2	0.3	0.6	0.8	-0.2	0.5
Medication: Allopurinol	0.2	0.2	0.3	0.6	0.6	0.3
Pulse rate, automated reading	0.2	0.5	1.4	0.1	0.2	-1.2
Loneliness, isolation	0.2	0.3	0.7	0.4	0.8	0.5
Long-standing illness, disability or infirmity	0.2	0.4	0.9	-0.3	0.4	-0.9
Friendships satisfaction	0.2	0.2	0.4	-0.5	0.6	-0.0
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.4	0.6	0.4
Miserableness	0.2	0.4	0.9	0.5	0.2	-1.0
Mother’s age at death	0.2	0.3	0.5	0.7	-0.0	0.6
Alcohol drinker status: Never	0.2	0.3	0.6	0.2	-0.4	0.8
Arm fat-free mass (left)	0.2	0.9	2.2	1.5	0.1	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.6	-0.4	-0.4
Arm predicted mass (left)	0.2	1.1	3.1	1.8	-0.0	-0.2
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	-0.2	-0.1	-0.7
Fasting Glucose	0.1	0.1	0.2	0.1	-0.5	0.3
Blood Eosinophil Count	0.1	0.8	1.9	-0.7	-0.3	-1.4
Blood Red Count	0.1	0.7	1.5	0.3	-0.7	1.2
Waist Hip Ratio (WHR)	0.1	0.5	1.1	-0.0	-0.7	-1.0
Hair Pigment	0.1	3.1	4.5	-2.1	1.6	1.5
Hearing difficulty/problems: Yes	0.1	0.1	0.3	0.1	0.6	-0.1
Diabetes (mother)	0.1	0.1	0.1	-0.4	0.3	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	-0.2	-0.7	0.3
High blood pressure (mother)	0.1	0.1	0.1	0.3	0.2	0.4
Had menopause	0.1	0.2	0.4	-0.0	-0.6	0.3
Time employed in main current job	0.1	0.1	0.3	-0.5	-0.1	-0.0
Headache pain in last month	0.1	0.2	0.5	-0.7	0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.8	-0.3	-0.9	0.2
Pulse wave peak to peak time	0.1	0.1	0.2	-0.1	-0.4	-0.4
Chest pain or discomfort	0.1	0.1	0.2	-0.0	-0.5	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.2	0.5	-0.4
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.5	-0.1	0.1
Medication: Paracetamol	0.1	0.1	0.2	0.2	0.3	-0.4
Medication: Atorvastatin	0.1	0.2	0.3	-0.4	-0.2	-0.5
Ever depressed for a whole week	0.1	0.2	0.4	-0.1	0.6	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	0.5	0.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	0.1	-0.0	0.1
Alcohol intake frequency.	0.0	0.1	0.3	0.1	-0.6	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	0.2	-0.1	-0.2
Unable to work because of sickness or disability	0.0	0.0	0.0	0.0	0.0	0.1

Hub : Genes

ZCCHC14

Models

Trait associations