Hub : Genes

PIK3R1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.047	0.022	0.0200	-0.001	0.005	-0.001	0.005	-0.001	4.4e-01	7.3e-02	5.0e-01	7.4e-02	5.3e-01
2	YFS	Blood	0.253	0.032	0.0000	0.047	0.180	0.172	0.179	0.161	4.3e-15	1.7e-56	9.5e-54	4.6e-56	2.3e-50
3	TCGA	Glioblastoma Multiforme	0.233	0.111	0.0055	0.029	0.020	0.023	NA	0.043	4.5e-02	7.9e-02	6.5e-02	NA	2.0e-02
4	TCGA	Rectum Adenocarcinoma	0.210	0.089	0.0054	0.009	0.085	0.061	NA	0.023	1.9e-01	5.0e-03	1.6e-02	NA	9.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.5	2.8	1.5	0.4	1.7	-0.9
Bipolar Disorder or Schizophrenia	0.6	1.5	4.8	0.8	-0.1	0.7	-2.2
Depressed Affect (Nagel 2018)	1.0	2.1	5.3	0.4	-1.5	-0.7	2.3
Depression (Nagel 2018)	1.3	1.9	3.0	-1.4	-0.8	-1.4	1.7
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.5	-1.3	0.0	1.2	-1.6
Neuroticism (Nagel 2018)	0.8	1.9	6.6	-1.0	-0.3	-0.0	2.6
Schizophrenia (2018)	0.6	1.2	4.5	-0.3	-0.5	-0.4	-2.1
Schizophrenia vs Biploar Disorder	0.6	0.7	2.9	-0.1	-0.2	-1.7	0.2
Worry (Nagel 2018)	1.2	2.5	6.5	-1.2	0.9	1.1	2.5
Alzheimer’s Disease (in mother)	0.7	0.8	1.8	-0.9	0.1	-1.4	-0.8
Alzheimer’s Disease (in father)	0.5	0.6	1.3	-1.0	0.1	-1.1	0.1
Alzheimer’s Disease (including proxy)	0.9	1.4	5.3	-0.4	-0.2	-2.3	-0.1
Crohns Disease (2017)	0.1	0.3	0.5	0.3	0.2	0.6	0.7
Irritable Bowel Disease (IBD)	0.4	1.0	2.2	-0.1	-1.1	-1.5	0.7
Ulcerative Colitis (UC)	1.5	2.8	6.9	-0.3	-2.0	-2.6	0.6
Major Depression (MDD)	2.1	2.5	5.0	-2.0	-2.2	-0.9	-0.4
Reaction Time	1.5	2.9	9.3	3.0	0.5	0.7	1.3
Verbal and Numeric Reasoning (VNR)	0.8	1.9	5.8	-1.3	-0.5	-0.2	-2.4
Breast Cancer	4.8	11.6	21.5	2.9	2.0	4.6	3.6
Ovarian Cancer	0.7	0.9	3.1	-0.0	-0.8	-0.2	-1.8
Prostate Cancer	0.4	0.5	1.3	-0.4	0.7	0.4	-1.1
Age at First Birth	0.5	0.7	1.7	1.3	0.3	-0.9	0.1
Bipolar Disorder (2011)	3.1	3.0	6.8	2.3	0.3	2.6	0.2
Body Mass Index (BMI) (2010)	1.0	1.4	3.5	-1.9	-0.1	-1.1	-0.8
Coronary Artery Disease (CAD)	1.6	1.9	2.8	1.5	-1.7	0.1	1.6
Crohns Disease (2012)	0.6	0.9	1.9	0.7	0.2	1.1	1.4
Mean Putamen Volume	1.9	2.2	6.6	0.0	-1.3	-2.6	0.4
Fasting Glucose	0.3	0.4	1.1	0.3	-0.1	0.6	-1.1
HbA1C	2.0	2.2	3.0	1.4	1.7	0.9	1.7
HDL Cholesterol	0.6	1.0	3.5	-0.5	1.9	0.3	-0.2
LDL Cholesterol	0.6	1.0	2.6	0.4	0.5	0.9	1.6
Lupus	0.6	0.8	2.1	0.2	-1.4	1.0	0.6
Neuroticism (2016)	0.5	0.7	1.5	-0.8	0.4	0.8	1.2
Primary Biliary Cirrhosis	1.1	1.6	4.0	-0.1	-2.0	-1.5	-0.2
Rheumatoid Arthritis	0.4	0.6	2.2	1.5	-0.4	0.3	0.0
Schizophrenia (2014)	0.6	1.4	4.3	-0.3	-0.9	-0.7	-2.1
Triglycerides	0.4	0.6	1.1	0.9	-1.0	-0.8	-0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.6	-0.1	1.3	0.7	0.6
Ulcerative Colitis	2.3	3.3	7.8	-1.1	-2.0	-2.8	0.4
Blood Eosinophil Count	0.7	5.4	17.4	-1.2	-1.5	-4.2	-0.8
Blood Platelet Count	0.1	0.8	2.7	0.1	-0.4	1.6	-0.5
Blood Red Count	2.4	23.4	51.6	-4.7	-3.3	-7.2	-3.1
Blood White Count	0.9	6.7	13.0	2.8	-3.6	-0.3	2.4
Heel T-Score	0.3	2.1	4.1	2.0	-2.0	-0.4	0.4
BMI	0.4	2.3	4.8	0.3	-2.2	-1.7	-1.2
Height	1.3	25.6	72.7	-5.2	1.4	-8.5	1.0
Waist Hip Ratio (WHR)	0.7	3.4	11.8	-1.2	0.2	-3.4	0.3
Systolic Blood Pressure	0.3	1.5	5.6	-0.0	0.1	2.4	0.7
Smoking Status	1.7	4.1	8.0	-1.1	-2.2	-2.8	-1.5
Allergy or Eczema	0.2	0.6	1.6	-0.5	-0.4	-1.2	0.7
Cardiovascular Disease	1.1	3.6	8.5	1.5	-0.3	1.9	2.9
Hypothyroidism (self reported)	0.2	0.4	1.1	-0.6	0.3	0.1	1.1
Respiratory disease	1.5	3.3	6.1	-2.5	-1.8	-1.8	0.9
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	0.5	-0.7	0.0	0.2
Lung FEV1/FVC ratio	0.1	0.4	0.7	-0.8	-0.8	0.1	0.6
Lung FVC	0.3	1.3	1.9	1.4	-1.1	0.6	1.4
Neuroticism	1.0	2.5	9.4	-0.6	-0.2	0.5	3.1
Chronotype (morning person)	0.7	1.7	3.5	1.6	0.6	-0.3	1.9
Hair Pigment	0.2	5.6	13.5	3.7	-0.6	2.3	1.9
Tanning	0.0	0.2	0.5	0.2	-0.1	0.7	-0.7
Hand grip strength (left)	0.4	1.1	1.6	-1.0	0.9	-1.0	-1.3
Number of treatments/medications taken	0.2	0.4	0.6	0.7	-0.7	0.2	-0.8
Average weekly spirits intake	0.2	0.3	0.5	0.7	-0.4	-0.2	-0.6
Sensitivity / hurt feelings	0.9	1.6	5.8	-0.7	0.2	0.3	2.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.1	-0.6	-0.4	-0.5	1.4
Hearing difficulty/problems: Yes	0.5	0.7	2.3	-1.5	0.0	-0.8	0.2
Relative age of first facial hair	0.9	1.8	5.6	1.0	0.7	2.4	-0.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.1	-1.1	0.1	-0.9	0.9
Ever used hormone-replacement therapy (HRT)	1.7	2.2	4.5	-0.7	-1.8	-0.7	-2.1
Ever had hysterectomy (womb removed)	1.4	1.6	3.3	-1.8	-0.4	-1.6	0.3
Systolic blood pressure, automated reading	0.1	0.3	0.8	-0.4	0.3	0.9	-0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.4	-0.3	-0.2	0.3
Angina	0.9	1.2	4.1	0.4	-0.6	0.1	-2.0
Medication for hormone replacement therapy	1.3	1.5	2.9	0.6	-1.7	1.6	0.2
Vitamin and mineral supplements	0.5	0.6	1.5	-0.1	0.9	-0.5	1.2
Supplements: Zinc	3.3	3.6	11.2	-1.7	-0.3	-0.4	-3.4
Medication: Co-codamol	0.1	0.1	0.3	0.5	0.2	-0.1	-0.1
Medication: Metformin	0.4	0.5	1.7	-0.1	-1.3	-0.6	-0.3
Diabetes (father)	0.5	0.7	1.9	-1.4	0.4	0.5	-0.6
Diabetes (mother)	0.3	0.3	1.0	0.2	-1.0	0.5	-0.4
Severe depression (siblings)	0.3	0.3	0.8	0.6	-0.5	-0.0	-0.9
Pack years adult smoking proportion	0.5	0.7	1.3	-0.5	-1.1	-0.4	-1.2
Impedance of leg (right)	0.5	2.5	8.1	-0.2	1.3	2.9	0.1
Leg fat-free mass (left)	1.5	7.7	27.4	-1.8	-0.2	-5.2	0.4
Trunk fat percentage	0.0	0.1	0.3	0.1	-0.1	-0.3	0.5
Hand grip strength (right)	0.6	1.6	2.2	-1.2	1.5	-1.3	-1.1
Townsend deprivation index at recruitment	0.5	0.6	2.5	0.1	0.0	1.6	-0.2
Current tobacco smoking	0.9	1.5	3.8	-0.2	-1.5	-2.0	-0.1
Average weekly fortified wine intake	0.1	0.1	0.3	-0.0	0.6	-0.3	0.4
Maternal smoking around birth	1.7	2.5	3.9	-1.3	-1.0	-2.0	-1.8
Fed-up feelings	0.5	1.0	3.1	0.3	-0.5	0.7	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	6.8	-0.6	-1.1	-1.3	2.6
Relative age voice broke	0.2	0.3	0.6	0.2	-0.6	0.8	-0.1
Taking other prescription medications	0.2	0.2	0.8	-0.4	-0.9	0.0	-0.2
Age when periods started (menarche)	0.3	0.7	2.2	0.2	0.7	1.5	0.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.7	-0.4	-1.7	-0.0	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.3	0.6	-0.9	0.0	-1.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.7	-0.3	0.8	0.8	0.7
Qualifications: CSEs or equivalent	0.2	0.3	0.8	0.3	-0.2	0.6	0.9
Serious illness, injury or assault to yourself	0.5	0.7	1.0	-0.7	1.0	-0.7	-0.7
High blood pressure	1.2	3.3	5.9	1.6	1.1	1.9	2.4
Hayfever, allergic rhinitis or eczema	0.4	1.0	1.9	-0.5	0.2	-1.4	1.3
Multivitamins +/- minerals	0.8	1.0	3.2	-0.3	-1.8	-0.3	-0.7
Stomach or abdominal pain in last month	1.0	1.2	2.8	-1.1	-0.8	-1.7	0.5
Supplements: Glucosamine	2.7	3.5	4.5	-1.9	-1.8	-1.7	-2.1
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.2	0.6	0.4	-0.9	2.1
Medication: Atenolol	3.8	4.8	9.7	3.1	1.3	1.4	2.4
Medication: Levothyroxine sodium	0.8	1.4	2.5	1.6	-0.9	1.3	0.9
Sitting height	1.7	12.4	37.5	-3.0	1.0	-6.1	-1.4
Chronic bronchitis/emphysema (father)	2.7	3.2	5.6	-0.4	-1.8	-1.9	-2.4
High blood pressure (mother)	0.4	0.6	1.2	0.7	0.6	1.1	-0.5
Body mass index (BMI)	0.3	1.2	2.7	0.5	-1.6	-1.3	0.3
Impedance of leg (left)	0.4	2.2	7.2	-0.2	1.2	2.7	0.1
Leg predicted mass (left)	1.4	7.6	27.4	-1.7	-0.3	-5.2	0.5
Trunk fat mass	0.3	1.3	4.6	-0.5	-0.6	-2.1	0.3
Waist circumference	1.1	3.9	12.2	-1.8	-0.3	-3.5	-0.4
Number of incorrect matches in round	0.6	0.9	1.4	0.9	-1.1	-0.6	-1.2
Past tobacco smoking	3.2	5.9	8.4	2.9	2.7	1.8	2.0
Alcohol usually taken with meals	0.6	1.0	2.5	-1.6	0.1	0.4	-1.2
Nervous feelings	0.2	0.4	1.4	-0.5	1.2	0.3	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.4	0.7	0.5	0.2	1.5
Hearing difficulty/problems with background noise	0.2	0.3	0.8	-0.9	-0.5	0.2	-0.4
Hair/balding pattern: Pattern 2	0.7	0.9	1.9	0.6	1.4	0.7	-0.9
Had menopause	0.6	0.8	2.8	-0.6	0.2	0.1	-1.7
Had other major operations	1.8	2.2	4.0	-2.0	-0.7	-0.9	-1.9
Forced vital capacity (FVC)	0.3	1.3	3.0	0.3	-0.4	-1.7	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.3	0.4	-0.4	0.3	-2.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.0	0.2	-1.0	0.3	0.2
Qualifications: None of the above	0.6	1.2	3.4	-0.1	-0.5	-1.9	1.0
Financial difficulties in last 2 years	0.3	0.4	1.1	0.4	1.0	0.6	0.1
Mouth/teeth dental problems	0.6	0.9	1.6	-0.5	1.0	0.8	1.2
Heart attack	0.2	0.3	0.7	0.8	-0.5	-0.5	-0.0
Allergy	1.5	3.4	8.0	2.1	1.0	2.8	-0.4
Pain all over the body in last month	0.9	1.0	1.8	1.4	-1.1	-0.2	0.9
Diabetes (self-reported)	0.0	0.1	0.2	-0.1	-0.2	-0.4	-0.0
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.2	-1.5	-1.0	-0.8	1.1
Medication: Ramipril	0.8	1.0	2.4	1.5	-0.2	1.2	-0.5
Medication: Simvastatin	0.5	0.8	1.3	0.9	-0.2	1.1	0.9
Fluid intelligence score	0.1	0.2	0.5	-0.7	0.3	0.6	0.2
Illnesses of siblings	0.4	0.6	1.4	-0.2	1.2	0.1	1.0
Neuroticism score	0.6	1.3	4.3	-0.8	-0.3	0.3	2.1
Weight	1.3	6.2	20.2	-1.9	-1.0	-4.5	0.2
Impedance of arm (right)	1.5	7.0	14.2	-1.4	3.3	3.8	-0.8
Arm fat percentage (right)	0.0	0.1	0.2	0.1	-0.3	0.4	-0.0
Trunk fat-free mass	2.9	16.7	55.4	-3.0	-1.3	-7.4	-1.0
Hip circumference	0.5	2.0	4.7	-1.8	0.2	-2.2	-0.0
Time employed in main current job	0.7	0.8	1.5	-0.0	-1.1	-1.2	-0.6
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.6	-0.9	-0.3	-0.0
Father’s age at death	0.6	0.7	1.7	-0.6	1.0	1.3	-0.1
Worrier / anxious feelings	1.3	2.4	9.6	0.2	0.4	0.1	3.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.5	-1.7	-1.9	-0.2	0.2
Falls in the last year	1.3	1.8	4.2	-0.7	-0.9	-2.0	-1.3
Hair/balding pattern: Pattern 3	0.7	1.0	2.8	0.8	0.2	0.8	1.7
Number of live births	0.9	1.3	2.6	0.1	-1.6	-1.6	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.5	0.6	-0.4	-0.8	1.2
Pulse rate	3.5	5.9	8.2	-1.8	-2.9	-1.9	-2.9
Happiness	1.1	1.3	3.5	0.1	-1.9	-0.1	1.3
Noisy workplace	0.6	0.8	1.5	-0.5	-0.5	-1.1	-1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.6	0.7	1.0	1.6	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.1	-1.0	-0.7	-0.2	-0.1
Mouth/teeth dental problems: Dentures	1.0	1.6	3.2	1.3	-1.8	-1.1	-0.7
Asthma	2.2	4.3	7.9	-2.8	-1.9	-2.3	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	-0.1	0.2	0.6	0.1
Medication: Cholesterol lowering	1.1	1.7	5.2	2.3	-0.9	0.6	0.7
Depression (self-reported)	1.0	1.2	2.2	-1.5	-1.3	-0.4	-0.7
Medication: Lansoprazole	0.4	0.5	0.9	0.9	0.5	-0.1	-0.9
Prospective memory result	1.5	1.9	4.0	2.0	0.1	-0.0	1.9
Lung cancer (father)	1.6	1.8	4.0	1.8	0.1	0.5	2.0
Illnesses of mother	0.2	0.3	0.7	0.4	-0.4	0.5	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.4	0.3	-0.5	-0.6	1.5
Pulse wave Arterial Stiffness index	1.0	1.2	2.7	0.3	-1.2	-1.6	-0.7
Impedance of arm (left)	1.3	6.2	13.8	-1.2	3.0	3.7	-0.4
Arm fat mass (right)	0.3	1.4	4.6	-0.5	-0.8	-2.1	0.0
Trunk predicted mass	2.9	16.6	55.4	-2.9	-1.2	-7.4	-1.0
Standing height	2.1	21.2	58.1	-5.0	1.2	-7.6	-0.2
Length of working week for main job	0.3	0.3	0.5	-0.4	0.4	0.6	-0.7
Exposure to tobacco smoke at home	0.9	1.0	2.7	1.6	-0.0	0.8	-0.7
Breastfed as a baby	0.7	0.9	1.8	0.1	1.3	1.3	-0.2
Tense / ‘highly strung’	1.1	1.9	4.7	0.5	2.2	0.7	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.6	0.8	-2.1	-0.1	0.8
Hair/balding pattern: Pattern 4	1.5	3.7	12.7	-0.5	0.5	-3.6	1.3
Birth weight of first child	3.1	5.6	15.4	-2.6	-0.1	-3.9	-0.5
Peak expiratory flow (PEF)	0.5	1.2	2.7	-0.9	0.1	-1.1	1.6
Pulse wave reflection index	0.5	0.7	1.6	1.0	-0.3	0.0	1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.2	0.0	-0.1	-1.5	0.3
Loud music exposure frequency	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.3	0.1	0.5	0.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.7	0.5	0.7	2.2	0.2
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.2	-0.0	-0.2	-0.3
Medication: Paracetamol	0.2	0.4	0.8	-0.9	0.0	0.1	-0.8
Headache pain in last month	0.6	1.1	4.2	0.2	-0.4	-2.0	0.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.6	-2.1	1.3	-0.4	0.1
Glaucoma (self-reported)	1.5	1.8	2.7	-1.4	-1.1	-1.6	-1.1
Gout (self-reported)	0.9	1.3	2.3	-1.5	-0.5	-1.1	-1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.1	-0.7	0.9	0.4
Medication: Amlodipine	0.1	0.1	0.4	-0.1	0.2	0.6	0.1
Medication: Ventolin 100micrograms inhaler	2.2	2.8	8.5	-1.2	-0.6	-2.9	-0.9
Birth weight	4.6	9.9	28.0	-1.8	-2.2	-5.3	-1.9
Chronic bronchitis/emphysema (mother)	0.8	1.0	3.2	0.7	-0.1	-0.4	1.8
High blood pressure (siblings)	0.3	0.4	0.9	0.7	-1.0	0.1	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.9	2.2	0.3	-0.5	-1.0	1.5
Body fat percentage	0.0	0.1	0.2	0.2	-0.5	0.0	0.4
Leg fat percentage (right)	0.2	0.7	0.9	1.0	-0.9	0.5	0.9
Arm fat-free mass (right)	2.3	11.6	43.2	-1.3	-1.1	-6.6	0.5
Exposure to tobacco smoke outside home	1.9	2.6	6.3	1.0	1.6	2.5	0.6
Comparative body size at age 10	0.1	0.4	0.9	0.6	0.1	-0.4	1.0
Number of full brothers	1.7	2.2	3.9	0.9	-1.6	2.0	-1.1
Worry too long after embarrassment	1.1	1.9	3.2	-1.2	1.8	0.2	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.1	0.2	0.8	0.9
Wheeze or whistling in the chest in last year	0.3	0.6	1.6	-1.2	0.2	-0.4	0.7
Number of children fathered	0.5	0.5	0.9	0.1	1.0	0.8	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.6	0.3	0.2	0.4
Age at first live birth	1.0	1.7	4.5	1.3	2.1	0.1	0.9
Pulse wave peak to peak time	1.0	1.2	2.3	-0.7	1.5	1.2	0.8
Health satisfaction	0.1	0.1	0.4	0.1	-0.0	-0.4	0.6
Shortness of breath walking on level ground	1.6	1.9	2.5	-1.4	-1.1	-1.6	-1.4
Qualifications: College or University degree	0.6	1.9	2.7	-1.6	0.8	1.5	-1.5
Eye problems/disorders: None of the above	1.5	1.8	4.3	1.3	0.5	2.1	0.9
Mouth/teeth dental problems: Loose teeth	1.4	1.6	4.3	-0.2	2.1	0.5	1.4
Emphysema/chronic bronchitis	0.4	0.4	0.5	0.4	0.7	0.7	0.7
Medication for pain relief, constipation, heartburn	0.2	0.3	1.1	0.1	0.1	-0.3	1.0
Neck or shoulder pain in last month	0.8	1.1	2.2	-0.6	-1.4	-1.5	-0.1
Medication: Blood pressure	0.4	0.7	2.2	1.5	-0.2	0.5	0.5
Angina (self-reported)	0.7	1.0	3.5	0.3	-0.6	0.1	-1.9
Migraine (self-reported)	0.3	0.3	0.8	0.4	0.5	0.9	0.3
Medication: Ibuprofen	0.3	0.3	0.5	0.3	0.4	0.7	0.7
Medication: Allopurinol	0.4	0.6	1.2	-0.6	-0.7	-0.4	-1.1
Medication: Omeprazole	0.6	0.8	1.1	0.6	-0.9	1.1	0.9
Medication: Seretide 50 evohaler	0.7	0.8	1.1	-1.0	-1.0	0.3	-1.0
Mean time to correctly identify matches	1.0	1.8	7.1	2.7	-0.1	0.5	0.1
Heart disease (mother)	0.5	0.6	2.1	-0.1	0.1	-0.4	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.8	-1.7	-0.9	0.5	-0.4
Whole body fat mass	0.3	1.4	4.4	-0.6	-0.9	-2.1	0.2
Leg fat mass (right)	0.4	1.4	3.7	-0.2	-1.2	-1.9	0.6
Arm predicted mass (right)	2.4	12.3	44.2	-1.7	-1.3	-6.6	0.5
Pulse rate, automated reading	2.0	6.5	14.7	-1.0	-3.8	-2.3	-2.2
Alcohol intake frequency.	0.2	0.5	1.6	0.4	-0.4	-0.1	-1.2
Comparative height size at age 10	3.5	19.2	56.7	-4.3	0.1	-7.5	-1.3
Number of full sisters	1.3	1.6	2.1	0.8	1.3	1.4	1.4
Suffer from ‘nerves’	0.7	1.0	2.4	-1.0	0.6	-0.6	1.5
Overall health rating	0.9	1.9	4.8	-1.5	0.5	-2.2	0.3
Chest pain or discomfort	1.3	1.8	3.6	-0.7	-0.1	-1.9	-1.8
Had major operations	0.7	0.9	1.5	-0.7	0.1	-1.1	-1.2
Age at last live birth	0.5	0.7	1.4	0.6	1.2	0.2	0.9
Family relationship satisfaction	1.2	1.5	3.0	0.8	-1.5	-0.4	-1.7
Leg pain on walking	1.5	1.9	4.2	0.1	-0.8	-1.7	-2.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.1	-0.2	-0.5	-0.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.7	0.4	-1.6	-0.8	0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.7	-0.4	0.5	0.8	-0.4
Medication: Aspirin	0.9	1.2	2.1	-0.2	-1.4	-1.4	-0.8
Supplements: Vitamin C	1.5	1.8	3.9	0.9	0.9	1.3	-2.0
Knee pain experienced in last month	1.9	3.0	6.0	-1.1	-2.2	-2.5	-0.4
Hypertension (Self-reported)	1.3	3.5	7.1	1.9	0.9	1.6	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.3	0.4	-1.1	1.1	0.6
Illnesses of father: Heart disease	0.7	1.0	2.9	-0.9	-0.0	-0.3	1.7
Illnesses of siblings: Diabetes	0.7	0.9	2.1	0.4	0.9	0.7	1.5
Smoking status: Previous	2.9	4.3	8.3	-2.9	-2.1	-1.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	4.5	-2.1	0.7	-0.9	1.6
Whole body fat-free mass	2.3	13.1	45.7	-2.4	-0.9	-6.8	-0.3
Leg fat-free mass (right)	1.5	8.0	28.6	-1.7	-0.3	-5.3	0.5
Arm fat percentage (left)	0.0	0.1	0.3	0.5	-0.2	0.5	0.2
Average weekly red wine intake	0.8	1.2	2.3	-1.3	0.7	0.8	-1.5
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.5	-0.1	0.1	1.6	-1.6
Mood swings	1.0	1.8	6.9	-0.1	0.0	0.7	2.6
Loneliness, isolation	0.7	1.0	2.5	-0.5	-1.0	-1.6	-0.4
Long-standing illness, disability or infirmity	0.4	0.6	1.0	-0.9	-0.6	-1.0	-0.3
Ever had bowel cancer screening	0.6	0.7	1.4	-0.2	-0.5	-1.2	-1.0
Diabetes diagnosed by doctor	0.1	0.2	0.8	-0.0	-0.9	-0.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.5	0.4	-0.4	0.4	-1.6
Friendships satisfaction	0.4	0.5	1.2	0.1	-0.9	-0.4	-1.1
Qualifications: nursing, teaching	0.2	0.3	0.8	-0.4	0.9	0.3	0.2
Commuting to job workplace: Walk	1.0	1.0	2.1	0.3	1.3	1.4	0.5
Eye problems/disorders: Cataract	1.2	1.4	2.6	-1.6	0.6	-1.6	0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.2	-0.6	0.4	-0.8
Medication for cholesterol	1.6	2.4	5.9	-0.7	0.6	-2.4	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.8	0.5	-0.6	0.1	-1.4
Back pain experienced in last month	1.5	2.2	7.3	-1.0	-0.1	-2.7	-0.6
Mineral and other dietary supplements	0.6	0.8	2.3	0.5	0.2	0.8	1.5
Breast cancer (self-reported)	3.3	3.9	8.4	-0.2	-0.9	-2.9	-2.5
Asthma (self-reported)	1.9	3.8	7.3	-2.7	-1.9	-2.0	0.5
Osteoporosis (self-reported)	0.5	0.7	1.6	0.2	1.2	-0.5	0.9
Osteoarthritis (self-reported)	0.8	1.0	2.7	0.9	-1.6	-0.0	-0.7
Medication: Aspirin	1.4	1.9	4.3	-0.2	-2.1	-1.6	-0.7
Medication: Gliclazide	0.8	0.9	2.8	0.0	1.7	-0.9	-0.1
Illnesses of father: None of the above (group 1)	0.7	0.9	1.7	0.7	-1.3	0.1	-1.2
Smoking status: Current	0.9	1.4	3.8	-0.1	-1.3	-2.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.2	1.8	-0.4	0.9	1.3
Whole body water mass	2.3	13.1	46.1	-2.3	-0.8	-6.8	-0.2
Leg predicted mass (right)	1.5	8.1	29.2	-1.8	-0.3	-5.4	0.4
Arm fat mass (left)	0.3	1.2	4.1	-0.4	-0.7	-2.0	0.1
Number of self-reported non-cancer illnesses	0.5	0.9	2.5	0.2	-0.8	-0.7	1.6
Average weekly champagne plus white wine intake	0.9	1.2	3.1	0.3	1.0	1.8	0.8
Miserableness	0.4	0.8	2.9	-0.1	-0.4	-0.1	1.7
Guilty feelings	0.3	0.5	1.3	-1.1	-0.1	0.2	0.8
Wears glasses or contact lenses	1.9	2.1	5.6	0.5	-1.6	-0.1	-2.4
Ever taken oral contraceptive pill	0.2	0.3	0.4	0.4	-0.5	0.6	0.5
Hearing aid user	1.1	1.2	2.1	0.1	-1.5	-1.4	-1.0
Mother’s age at death	1.2	1.5	2.4	0.9	1.5	1.4	1.0
Financial situation satisfaction	0.5	0.6	2.0	-0.7	-0.3	0.1	1.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.5	-0.6	-0.4	-0.7	-1.2
Commuting to job workplace: Public transport	1.3	1.5	2.4	0.0	1.5	1.6	1.3
Eye problems/disorders: Glaucoma	1.7	2.0	2.9	-1.2	-1.6	-1.2	-1.7
Medication: Blood pressure	1.2	2.2	4.1	-0.1	1.3	2.0	1.7
Pain type(s) experienced in last month: Hip pain	1.1	1.4	1.9	-1.4	-1.1	-1.1	-1.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.0	0.4	0.5	-0.4
High cholesterol (Self-reported)	0.6	1.0	1.4	1.2	-1.1	1.1	0.3
Medication: Bendroflumethiazide	0.7	1.1	1.3	1.1	-1.0	1.2	0.9
Medication: Paracetamol	0.0	0.0	0.1	-0.0	-0.2	-0.2	0.1
Medication: Lisinopril	0.9	1.2	2.5	-1.6	-0.1	-1.3	0.7
Medication: Atorvastatin	0.7	0.9	2.3	0.2	-1.1	-0.3	-1.5
Illnesses of father: High blood pressure	0.9	1.2	3.1	-1.2	1.7	0.4	-0.2
Alcohol drinker status: Never	0.3	0.3	1.0	1.0	-0.3	-0.3	-0.1
Ever smoked	1.7	3.0	4.8	-2.2	-1.9	-1.0	-1.6
Basal metabolic rate	2.1	11.6	39.9	-2.4	-0.9	-6.3	-0.1
Leg fat percentage (left)	0.2	0.6	1.0	1.0	-0.9	0.2	0.9
Arm fat-free mass (left)	2.5	12.8	46.0	-2.0	-1.1	-6.8	0.1
Number of operations (self-reported)	0.4	0.6	1.0	-0.3	-1.0	-0.6	-1.0
Average weekly beer plus cider intake	0.6	0.9	1.7	-0.1	-1.3	-0.4	-1.3
Irritability	0.2	0.4	0.9	-0.7	-1.0	0.3	0.2
Risk taking	1.1	1.7	4.6	-2.1	-0.1	-0.3	-1.4
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.4	0.2	0.4	0.1	-1.2
Fractured/broken bones in last 5 years	1.1	1.4	3.6	1.9	-0.9	1.1	0.1
Age started oral contraceptive pill	0.4	0.5	1.6	0.2	1.2	0.2	-0.4
Diastolic blood pressure, automated reading	0.4	1.3	3.2	-0.0	-1.8	0.3	-1.3
Ever depressed for a whole week	1.9	2.4	3.5	1.8	-0.5	1.6	1.9
Unable to work because of sickness or disability	0.9	1.1	2.6	-0.6	-0.7	-1.6	-1.1
Commuting to job workplace: Cycle	0.7	0.8	3.0	0.4	-0.1	1.7	0.4
Myopia	0.3	0.4	1.5	-0.3	0.3	1.2	-0.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	3.7	-1.9	-0.7	-1.5	-1.6
Cholesterol lowering medication	0.2	0.3	0.5	-0.6	-0.3	0.3	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.9	0.8	-0.6	1.0	0.8
Pain experienced in last month	1.3	2.2	8.1	-0.1	0.7	2.8	0.3
Supplements: Calcium	0.8	0.9	2.1	1.0	-0.2	1.4	-0.6
Basal cell carcinoma (self-reported)	1.5	1.8	3.4	-1.1	-1.4	-0.7	-1.9
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	0.9	-0.5	-0.3	0.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	-0.0	0.1	-0.3
Heart disease (siblings)	1.7	2.0	4.3	-0.7	-1.8	-0.3	-2.1
Alcohol drinker status: Previous	0.6	0.6	1.6	0.4	-0.9	0.3	-1.3
Pack years of smoking	0.5	0.7	1.5	-0.4	-1.0	-0.4	-1.2
Impedance of whole body	1.0	4.9	13.3	-0.6	2.5	3.6	0.2
Leg fat mass (left)	0.4	1.5	4.4	-0.2	-1.1	-2.1	0.6
Arm predicted mass (left)	2.4	12.4	44.6	-1.9	-1.1	-6.7	0.2