Hub : Genes

PIK3R1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.047 0.022 0.0200 -0.001 0.005 -0.001 0.005 -0.001 4.4e-01 7.3e-02 5.0e-01 7.4e-02 5.3e-01
2 YFS Blood 0.253 0.032 0.0000 0.047 0.180 0.172 0.179 0.161 4.3e-15 1.7e-56 9.5e-54 4.6e-56 2.3e-50
3 TCGA Glioblastoma Multiforme 0.233 0.111 0.0055 0.029 0.020 0.023 NA 0.043 4.5e-02 7.9e-02 6.5e-02 NA 2.0e-02
4 TCGA Rectum Adenocarcinoma 0.210 0.089 0.0054 0.009 0.085 0.061 NA 0.023 1.9e-01 5.0e-03 1.6e-02 NA 9.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.0 1.5 2.8 1.5 0.4 1.7 -0.9
Bipolar Disorder or Schizophrenia 0.6 1.5 4.8 0.8 -0.1 0.7 -2.2
Depressed Affect (Nagel 2018) 1.0 2.1 5.3 0.4 -1.5 -0.7 2.3
Depression (Nagel 2018) 1.3 1.9 3.0 -1.4 -0.8 -1.4 1.7
Intelligence (Savage-Jansen 2018) 0.5 1.4 2.5 -1.3 0.0 1.2 -1.6
Neuroticism (Nagel 2018) 0.8 1.9 6.6 -1.0 -0.3 -0.0 2.6
Schizophrenia (2018) 0.6 1.2 4.5 -0.3 -0.5 -0.4 -2.1
Schizophrenia vs Biploar Disorder 0.6 0.7 2.9 -0.1 -0.2 -1.7 0.2
Worry (Nagel 2018) 1.2 2.5 6.5 -1.2 0.9 1.1 2.5
Alzheimer’s Disease (in mother) 0.7 0.8 1.8 -0.9 0.1 -1.4 -0.8
Alzheimer’s Disease (in father) 0.5 0.6 1.3 -1.0 0.1 -1.1 0.1
Alzheimer’s Disease (including proxy) 0.9 1.4 5.3 -0.4 -0.2 -2.3 -0.1
Crohns Disease (2017) 0.1 0.3 0.5 0.3 0.2 0.6 0.7
Irritable Bowel Disease (IBD) 0.4 1.0 2.2 -0.1 -1.1 -1.5 0.7
Ulcerative Colitis (UC) 1.5 2.8 6.9 -0.3 -2.0 -2.6 0.6
Major Depression (MDD) 2.1 2.5 5.0 -2.0 -2.2 -0.9 -0.4
Reaction Time 1.5 2.9 9.3 3.0 0.5 0.7 1.3
Verbal and Numeric Reasoning (VNR) 0.8 1.9 5.8 -1.3 -0.5 -0.2 -2.4
Breast Cancer 4.8 11.6 21.5 2.9 2.0 4.6 3.6
Ovarian Cancer 0.7 0.9 3.1 -0.0 -0.8 -0.2 -1.8
Prostate Cancer 0.4 0.5 1.3 -0.4 0.7 0.4 -1.1
Age at First Birth 0.5 0.7 1.7 1.3 0.3 -0.9 0.1
Bipolar Disorder (2011) 3.1 3.0 6.8 2.3 0.3 2.6 0.2
Body Mass Index (BMI) (2010) 1.0 1.4 3.5 -1.9 -0.1 -1.1 -0.8
Coronary Artery Disease (CAD) 1.6 1.9 2.8 1.5 -1.7 0.1 1.6
Crohns Disease (2012) 0.6 0.9 1.9 0.7 0.2 1.1 1.4
Mean Putamen Volume 1.9 2.2 6.6 0.0 -1.3 -2.6 0.4
Fasting Glucose 0.3 0.4 1.1 0.3 -0.1 0.6 -1.1
HbA1C 2.0 2.2 3.0 1.4 1.7 0.9 1.7
HDL Cholesterol 0.6 1.0 3.5 -0.5 1.9 0.3 -0.2
LDL Cholesterol 0.6 1.0 2.6 0.4 0.5 0.9 1.6
Lupus 0.6 0.8 2.1 0.2 -1.4 1.0 0.6
Neuroticism (2016) 0.5 0.7 1.5 -0.8 0.4 0.8 1.2
Primary Biliary Cirrhosis 1.1 1.6 4.0 -0.1 -2.0 -1.5 -0.2
Rheumatoid Arthritis 0.4 0.6 2.2 1.5 -0.4 0.3 0.0
Schizophrenia (2014) 0.6 1.4 4.3 -0.3 -0.9 -0.7 -2.1
Triglycerides 0.4 0.6 1.1 0.9 -1.0 -0.8 -0.2
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.6 -0.1 1.3 0.7 0.6
Ulcerative Colitis 2.3 3.3 7.8 -1.1 -2.0 -2.8 0.4
Blood Eosinophil Count 0.7 5.4 17.4 -1.2 -1.5 -4.2 -0.8
Blood Platelet Count 0.1 0.8 2.7 0.1 -0.4 1.6 -0.5
Blood Red Count 2.4 23.4 51.6 -4.7 -3.3 -7.2 -3.1
Blood White Count 0.9 6.7 13.0 2.8 -3.6 -0.3 2.4
Heel T-Score 0.3 2.1 4.1 2.0 -2.0 -0.4 0.4
BMI 0.4 2.3 4.8 0.3 -2.2 -1.7 -1.2
Height 1.3 25.6 72.7 -5.2 1.4 -8.5 1.0
Waist Hip Ratio (WHR) 0.7 3.4 11.8 -1.2 0.2 -3.4 0.3
Systolic Blood Pressure 0.3 1.5 5.6 -0.0 0.1 2.4 0.7
Smoking Status 1.7 4.1 8.0 -1.1 -2.2 -2.8 -1.5
Allergy or Eczema 0.2 0.6 1.6 -0.5 -0.4 -1.2 0.7
Cardiovascular Disease 1.1 3.6 8.5 1.5 -0.3 1.9 2.9
Hypothyroidism (self reported) 0.2 0.4 1.1 -0.6 0.3 0.1 1.1
Respiratory disease 1.5 3.3 6.1 -2.5 -1.8 -1.8 0.9
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.5 0.5 -0.7 0.0 0.2
Lung FEV1/FVC ratio 0.1 0.4 0.7 -0.8 -0.8 0.1 0.6
Lung FVC 0.3 1.3 1.9 1.4 -1.1 0.6 1.4
Neuroticism 1.0 2.5 9.4 -0.6 -0.2 0.5 3.1
Chronotype (morning person) 0.7 1.7 3.5 1.6 0.6 -0.3 1.9
Hair Pigment 0.2 5.6 13.5 3.7 -0.6 2.3 1.9
Tanning 0.0 0.2 0.5 0.2 -0.1 0.7 -0.7
Hand grip strength (left) 0.4 1.1 1.6 -1.0 0.9 -1.0 -1.3
Number of treatments/medications taken 0.2 0.4 0.6 0.7 -0.7 0.2 -0.8
Average weekly spirits intake 0.2 0.3 0.5 0.7 -0.4 -0.2 -0.6
Sensitivity / hurt feelings 0.9 1.6 5.8 -0.7 0.2 0.3 2.4
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.1 -0.6 -0.4 -0.5 1.4
Hearing difficulty/problems: Yes 0.5 0.7 2.3 -1.5 0.0 -0.8 0.2
Relative age of first facial hair 0.9 1.8 5.6 1.0 0.7 2.4 -0.3
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.1 -1.1 0.1 -0.9 0.9
Ever used hormone-replacement therapy (HRT) 1.7 2.2 4.5 -0.7 -1.8 -0.7 -2.1
Ever had hysterectomy (womb removed) 1.4 1.6 3.3 -1.8 -0.4 -1.6 0.3
Systolic blood pressure, automated reading 0.1 0.3 0.8 -0.4 0.3 0.9 -0.5
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.4 -0.3 -0.2 0.3
Angina 0.9 1.2 4.1 0.4 -0.6 0.1 -2.0
Medication for hormone replacement therapy 1.3 1.5 2.9 0.6 -1.7 1.6 0.2
Vitamin and mineral supplements 0.5 0.6 1.5 -0.1 0.9 -0.5 1.2
Supplements: Zinc 3.3 3.6 11.2 -1.7 -0.3 -0.4 -3.4
Medication: Co-codamol 0.1 0.1 0.3 0.5 0.2 -0.1 -0.1
Medication: Metformin 0.4 0.5 1.7 -0.1 -1.3 -0.6 -0.3
Diabetes (father) 0.5 0.7 1.9 -1.4 0.4 0.5 -0.6
Diabetes (mother) 0.3 0.3 1.0 0.2 -1.0 0.5 -0.4
Severe depression (siblings) 0.3 0.3 0.8 0.6 -0.5 -0.0 -0.9
Pack years adult smoking proportion 0.5 0.7 1.3 -0.5 -1.1 -0.4 -1.2
Impedance of leg (right) 0.5 2.5 8.1 -0.2 1.3 2.9 0.1
Leg fat-free mass (left) 1.5 7.7 27.4 -1.8 -0.2 -5.2 0.4
Trunk fat percentage 0.0 0.1 0.3 0.1 -0.1 -0.3 0.5
Hand grip strength (right) 0.6 1.6 2.2 -1.2 1.5 -1.3 -1.1
Townsend deprivation index at recruitment 0.5 0.6 2.5 0.1 0.0 1.6 -0.2
Current tobacco smoking 0.9 1.5 3.8 -0.2 -1.5 -2.0 -0.1
Average weekly fortified wine intake 0.1 0.1 0.3 -0.0 0.6 -0.3 0.4
Maternal smoking around birth 1.7 2.5 3.9 -1.3 -1.0 -2.0 -1.8
Fed-up feelings 0.5 1.0 3.1 0.3 -0.5 0.7 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.5 6.8 -0.6 -1.1 -1.3 2.6
Relative age voice broke 0.2 0.3 0.6 0.2 -0.6 0.8 -0.1
Taking other prescription medications 0.2 0.2 0.8 -0.4 -0.9 0.0 -0.2
Age when periods started (menarche) 0.3 0.7 2.2 0.2 0.7 1.5 0.2
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.7 -0.4 -1.7 -0.0 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.3 0.6 -0.9 0.0 -1.5
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 0.7 -0.3 0.8 0.8 0.7
Qualifications: CSEs or equivalent 0.2 0.3 0.8 0.3 -0.2 0.6 0.9
Serious illness, injury or assault to yourself 0.5 0.7 1.0 -0.7 1.0 -0.7 -0.7
High blood pressure 1.2 3.3 5.9 1.6 1.1 1.9 2.4
Hayfever, allergic rhinitis or eczema 0.4 1.0 1.9 -0.5 0.2 -1.4 1.3
Multivitamins +/- minerals 0.8 1.0 3.2 -0.3 -1.8 -0.3 -0.7
Stomach or abdominal pain in last month 1.0 1.2 2.8 -1.1 -0.8 -1.7 0.5
Supplements: Glucosamine 2.7 3.5 4.5 -1.9 -1.8 -1.7 -2.1
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 4.2 0.6 0.4 -0.9 2.1
Medication: Atenolol 3.8 4.8 9.7 3.1 1.3 1.4 2.4
Medication: Levothyroxine sodium 0.8 1.4 2.5 1.6 -0.9 1.3 0.9
Sitting height 1.7 12.4 37.5 -3.0 1.0 -6.1 -1.4
Chronic bronchitis/emphysema (father) 2.7 3.2 5.6 -0.4 -1.8 -1.9 -2.4
High blood pressure (mother) 0.4 0.6 1.2 0.7 0.6 1.1 -0.5
Body mass index (BMI) 0.3 1.2 2.7 0.5 -1.6 -1.3 0.3
Impedance of leg (left) 0.4 2.2 7.2 -0.2 1.2 2.7 0.1
Leg predicted mass (left) 1.4 7.6 27.4 -1.7 -0.3 -5.2 0.5
Trunk fat mass 0.3 1.3 4.6 -0.5 -0.6 -2.1 0.3
Waist circumference 1.1 3.9 12.2 -1.8 -0.3 -3.5 -0.4
Number of incorrect matches in round 0.6 0.9 1.4 0.9 -1.1 -0.6 -1.2
Past tobacco smoking 3.2 5.9 8.4 2.9 2.7 1.8 2.0
Alcohol usually taken with meals 0.6 1.0 2.5 -1.6 0.1 0.4 -1.2
Nervous feelings 0.2 0.4 1.4 -0.5 1.2 0.3 0.0
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.4 0.7 0.5 0.2 1.5
Hearing difficulty/problems with background noise 0.2 0.3 0.8 -0.9 -0.5 0.2 -0.4
Hair/balding pattern: Pattern 2 0.7 0.9 1.9 0.6 1.4 0.7 -0.9
Had menopause 0.6 0.8 2.8 -0.6 0.2 0.1 -1.7
Had other major operations 1.8 2.2 4.0 -2.0 -0.7 -0.9 -1.9
Forced vital capacity (FVC) 0.3 1.3 3.0 0.3 -0.4 -1.7 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 4.3 0.4 -0.4 0.3 -2.1
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 1.0 0.2 -1.0 0.3 0.2
Qualifications: None of the above 0.6 1.2 3.4 -0.1 -0.5 -1.9 1.0
Financial difficulties in last 2 years 0.3 0.4 1.1 0.4 1.0 0.6 0.1
Mouth/teeth dental problems 0.6 0.9 1.6 -0.5 1.0 0.8 1.2
Heart attack 0.2 0.3 0.7 0.8 -0.5 -0.5 -0.0
Allergy 1.5 3.4 8.0 2.1 1.0 2.8 -0.4
Pain all over the body in last month 0.9 1.0 1.8 1.4 -1.1 -0.2 0.9
Diabetes (self-reported) 0.0 0.1 0.2 -0.1 -0.2 -0.4 -0.0
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.2 -1.5 -1.0 -0.8 1.1
Medication: Ramipril 0.8 1.0 2.4 1.5 -0.2 1.2 -0.5
Medication: Simvastatin 0.5 0.8 1.3 0.9 -0.2 1.1 0.9
Fluid intelligence score 0.1 0.2 0.5 -0.7 0.3 0.6 0.2
Illnesses of siblings 0.4 0.6 1.4 -0.2 1.2 0.1 1.0
Neuroticism score 0.6 1.3 4.3 -0.8 -0.3 0.3 2.1
Weight 1.3 6.2 20.2 -1.9 -1.0 -4.5 0.2
Impedance of arm (right) 1.5 7.0 14.2 -1.4 3.3 3.8 -0.8
Arm fat percentage (right) 0.0 0.1 0.2 0.1 -0.3 0.4 -0.0
Trunk fat-free mass 2.9 16.7 55.4 -3.0 -1.3 -7.4 -1.0
Hip circumference 0.5 2.0 4.7 -1.8 0.2 -2.2 -0.0
Time employed in main current job 0.7 0.8 1.5 -0.0 -1.1 -1.2 -0.6
Alcohol intake versus 10 years previously 0.2 0.3 0.8 -0.6 -0.9 -0.3 -0.0
Father’s age at death 0.6 0.7 1.7 -0.6 1.0 1.3 -0.1
Worrier / anxious feelings 1.3 2.4 9.6 0.2 0.4 0.1 3.1
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 3.5 -1.7 -1.9 -0.2 0.2
Falls in the last year 1.3 1.8 4.2 -0.7 -0.9 -2.0 -1.3
Hair/balding pattern: Pattern 3 0.7 1.0 2.8 0.8 0.2 0.8 1.7
Number of live births 0.9 1.3 2.6 0.1 -1.6 -1.6 -0.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.5 0.6 -0.4 -0.8 1.2
Pulse rate 3.5 5.9 8.2 -1.8 -2.9 -1.9 -2.9
Happiness 1.1 1.3 3.5 0.1 -1.9 -0.1 1.3
Noisy workplace 0.6 0.8 1.5 -0.5 -0.5 -1.1 -1.2
Qualifications: A levels/AS levels or equivalent 0.6 1.3 2.6 0.7 1.0 1.6 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.1 -1.0 -0.7 -0.2 -0.1
Mouth/teeth dental problems: Dentures 1.0 1.6 3.2 1.3 -1.8 -1.1 -0.7
Asthma 2.2 4.3 7.9 -2.8 -1.9 -2.3 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.3 -0.1 0.2 0.6 0.1
Medication: Cholesterol lowering 1.1 1.7 5.2 2.3 -0.9 0.6 0.7
Depression (self-reported) 1.0 1.2 2.2 -1.5 -1.3 -0.4 -0.7
Medication: Lansoprazole 0.4 0.5 0.9 0.9 0.5 -0.1 -0.9
Prospective memory result 1.5 1.9 4.0 2.0 0.1 -0.0 1.9
Lung cancer (father) 1.6 1.8 4.0 1.8 0.1 0.5 2.0
Illnesses of mother 0.2 0.3 0.7 0.4 -0.4 0.5 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 2.4 0.3 -0.5 -0.6 1.5
Pulse wave Arterial Stiffness index 1.0 1.2 2.7 0.3 -1.2 -1.6 -0.7
Impedance of arm (left) 1.3 6.2 13.8 -1.2 3.0 3.7 -0.4
Arm fat mass (right) 0.3 1.4 4.6 -0.5 -0.8 -2.1 0.0
Trunk predicted mass 2.9 16.6 55.4 -2.9 -1.2 -7.4 -1.0
Standing height 2.1 21.2 58.1 -5.0 1.2 -7.6 -0.2
Length of working week for main job 0.3 0.3 0.5 -0.4 0.4 0.6 -0.7
Exposure to tobacco smoke at home 0.9 1.0 2.7 1.6 -0.0 0.8 -0.7
Breastfed as a baby 0.7 0.9 1.8 0.1 1.3 1.3 -0.2
Tense / ‘highly strung’ 1.1 1.9 4.7 0.5 2.2 0.7 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 4.6 0.8 -2.1 -0.1 0.8
Hair/balding pattern: Pattern 4 1.5 3.7 12.7 -0.5 0.5 -3.6 1.3
Birth weight of first child 3.1 5.6 15.4 -2.6 -0.1 -3.9 -0.5
Peak expiratory flow (PEF) 0.5 1.2 2.7 -0.9 0.1 -1.1 1.6
Pulse wave reflection index 0.5 0.7 1.6 1.0 -0.3 0.0 1.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 2.2 0.0 -0.1 -1.5 0.3
Loud music exposure frequency 0.0 0.0 0.1 -0.1 -0.0 -0.1 -0.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 -0.3 0.1 0.5 0.1
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 4.7 0.5 0.7 2.2 0.2
Blood clot in the leg (DVT) 0.0 0.0 0.1 0.2 -0.0 -0.2 -0.3
Medication: Paracetamol 0.2 0.4 0.8 -0.9 0.0 0.1 -0.8
Headache pain in last month 0.6 1.1 4.2 0.2 -0.4 -2.0 0.3
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 4.6 -2.1 1.3 -0.4 0.1
Glaucoma (self-reported) 1.5 1.8 2.7 -1.4 -1.1 -1.6 -1.1
Gout (self-reported) 0.9 1.3 2.3 -1.5 -0.5 -1.1 -1.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 0.1 -0.7 0.9 0.4
Medication: Amlodipine 0.1 0.1 0.4 -0.1 0.2 0.6 0.1
Medication: Ventolin 100micrograms inhaler 2.2 2.8 8.5 -1.2 -0.6 -2.9 -0.9
Birth weight 4.6 9.9 28.0 -1.8 -2.2 -5.3 -1.9
Chronic bronchitis/emphysema (mother) 0.8 1.0 3.2 0.7 -0.1 -0.4 1.8
High blood pressure (siblings) 0.3 0.4 0.9 0.7 -1.0 0.1 -0.2
Forced vital capacity (FVC), Best measure 0.2 0.9 2.2 0.3 -0.5 -1.0 1.5
Body fat percentage 0.0 0.1 0.2 0.2 -0.5 0.0 0.4
Leg fat percentage (right) 0.2 0.7 0.9 1.0 -0.9 0.5 0.9
Arm fat-free mass (right) 2.3 11.6 43.2 -1.3 -1.1 -6.6 0.5
Exposure to tobacco smoke outside home 1.9 2.6 6.3 1.0 1.6 2.5 0.6
Comparative body size at age 10 0.1 0.4 0.9 0.6 0.1 -0.4 1.0
Number of full brothers 1.7 2.2 3.9 0.9 -1.6 2.0 -1.1
Worry too long after embarrassment 1.1 1.9 3.2 -1.2 1.8 0.2 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.8 -0.1 0.2 0.8 0.9
Wheeze or whistling in the chest in last year 0.3 0.6 1.6 -1.2 0.2 -0.4 0.7
Number of children fathered 0.5 0.5 0.9 0.1 1.0 0.8 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.4 0.6 0.3 0.2 0.4
Age at first live birth 1.0 1.7 4.5 1.3 2.1 0.1 0.9
Pulse wave peak to peak time 1.0 1.2 2.3 -0.7 1.5 1.2 0.8
Health satisfaction 0.1 0.1 0.4 0.1 -0.0 -0.4 0.6
Shortness of breath walking on level ground 1.6 1.9 2.5 -1.4 -1.1 -1.6 -1.4
Qualifications: College or University degree 0.6 1.9 2.7 -1.6 0.8 1.5 -1.5
Eye problems/disorders: None of the above 1.5 1.8 4.3 1.3 0.5 2.1 0.9
Mouth/teeth dental problems: Loose teeth 1.4 1.6 4.3 -0.2 2.1 0.5 1.4
Emphysema/chronic bronchitis 0.4 0.4 0.5 0.4 0.7 0.7 0.7
Medication for pain relief, constipation, heartburn 0.2 0.3 1.1 0.1 0.1 -0.3 1.0
Neck or shoulder pain in last month 0.8 1.1 2.2 -0.6 -1.4 -1.5 -0.1
Medication: Blood pressure 0.4 0.7 2.2 1.5 -0.2 0.5 0.5
Angina (self-reported) 0.7 1.0 3.5 0.3 -0.6 0.1 -1.9
Migraine (self-reported) 0.3 0.3 0.8 0.4 0.5 0.9 0.3
Medication: Ibuprofen 0.3 0.3 0.5 0.3 0.4 0.7 0.7
Medication: Allopurinol 0.4 0.6 1.2 -0.6 -0.7 -0.4 -1.1
Medication: Omeprazole 0.6 0.8 1.1 0.6 -0.9 1.1 0.9
Medication: Seretide 50 evohaler 0.7 0.8 1.1 -1.0 -1.0 0.3 -1.0
Mean time to correctly identify matches 1.0 1.8 7.1 2.7 -0.1 0.5 0.1
Heart disease (mother) 0.5 0.6 2.1 -0.1 0.1 -0.4 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 2.8 -1.7 -0.9 0.5 -0.4
Whole body fat mass 0.3 1.4 4.4 -0.6 -0.9 -2.1 0.2
Leg fat mass (right) 0.4 1.4 3.7 -0.2 -1.2 -1.9 0.6
Arm predicted mass (right) 2.4 12.3 44.2 -1.7 -1.3 -6.6 0.5
Pulse rate, automated reading 2.0 6.5 14.7 -1.0 -3.8 -2.3 -2.2
Alcohol intake frequency. 0.2 0.5 1.6 0.4 -0.4 -0.1 -1.2
Comparative height size at age 10 3.5 19.2 56.7 -4.3 0.1 -7.5 -1.3
Number of full sisters 1.3 1.6 2.1 0.8 1.3 1.4 1.4
Suffer from ‘nerves’ 0.7 1.0 2.4 -1.0 0.6 -0.6 1.5
Overall health rating 0.9 1.9 4.8 -1.5 0.5 -2.2 0.3
Chest pain or discomfort 1.3 1.8 3.6 -0.7 -0.1 -1.9 -1.8
Had major operations 0.7 0.9 1.5 -0.7 0.1 -1.1 -1.2
Age at last live birth 0.5 0.7 1.4 0.6 1.2 0.2 0.9
Family relationship satisfaction 1.2 1.5 3.0 0.8 -1.5 -0.4 -1.7
Leg pain on walking 1.5 1.9 4.2 0.1 -0.8 -1.7 -2.0
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.4 -0.1 -0.2 -0.5 -0.6
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.7 0.4 -1.6 -0.8 0.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.7 -0.4 0.5 0.8 -0.4
Medication: Aspirin 0.9 1.2 2.1 -0.2 -1.4 -1.4 -0.8
Supplements: Vitamin C 1.5 1.8 3.9 0.9 0.9 1.3 -2.0
Knee pain experienced in last month 1.9 3.0 6.0 -1.1 -2.2 -2.5 -0.4
Hypertension (Self-reported) 1.3 3.5 7.1 1.9 0.9 1.6 2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.3 0.4 -1.1 1.1 0.6
Illnesses of father: Heart disease 0.7 1.0 2.9 -0.9 -0.0 -0.3 1.7
Illnesses of siblings: Diabetes 0.7 0.9 2.1 0.4 0.9 0.7 1.5
Smoking status: Previous 2.9 4.3 8.3 -2.9 -2.1 -1.6 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 4.5 -2.1 0.7 -0.9 1.6
Whole body fat-free mass 2.3 13.1 45.7 -2.4 -0.9 -6.8 -0.3
Leg fat-free mass (right) 1.5 8.0 28.6 -1.7 -0.3 -5.3 0.5
Arm fat percentage (left) 0.0 0.1 0.3 0.5 -0.2 0.5 0.2
Average weekly red wine intake 0.8 1.2 2.3 -1.3 0.7 0.8 -1.5
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.5 -0.1 0.1 1.6 -1.6
Mood swings 1.0 1.8 6.9 -0.1 0.0 0.7 2.6
Loneliness, isolation 0.7 1.0 2.5 -0.5 -1.0 -1.6 -0.4
Long-standing illness, disability or infirmity 0.4 0.6 1.0 -0.9 -0.6 -1.0 -0.3
Ever had bowel cancer screening 0.6 0.7 1.4 -0.2 -0.5 -1.2 -1.0
Diabetes diagnosed by doctor 0.1 0.2 0.8 -0.0 -0.9 -0.4 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 2.5 0.4 -0.4 0.4 -1.6
Friendships satisfaction 0.4 0.5 1.2 0.1 -0.9 -0.4 -1.1
Qualifications: nursing, teaching 0.2 0.3 0.8 -0.4 0.9 0.3 0.2
Commuting to job workplace: Walk 1.0 1.0 2.1 0.3 1.3 1.4 0.5
Eye problems/disorders: Cataract 1.2 1.4 2.6 -1.6 0.6 -1.6 0.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.6 -0.2 -0.6 0.4 -0.8
Medication for cholesterol 1.6 2.4 5.9 -0.7 0.6 -2.4 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.8 0.5 -0.6 0.1 -1.4
Back pain experienced in last month 1.5 2.2 7.3 -1.0 -0.1 -2.7 -0.6
Mineral and other dietary supplements 0.6 0.8 2.3 0.5 0.2 0.8 1.5
Breast cancer (self-reported) 3.3 3.9 8.4 -0.2 -0.9 -2.9 -2.5
Asthma (self-reported) 1.9 3.8 7.3 -2.7 -1.9 -2.0 0.5
Osteoporosis (self-reported) 0.5 0.7 1.6 0.2 1.2 -0.5 0.9
Osteoarthritis (self-reported) 0.8 1.0 2.7 0.9 -1.6 -0.0 -0.7
Medication: Aspirin 1.4 1.9 4.3 -0.2 -2.1 -1.6 -0.7
Medication: Gliclazide 0.8 0.9 2.8 0.0 1.7 -0.9 -0.1
Illnesses of father: None of the above (group 1) 0.7 0.9 1.7 0.7 -1.3 0.1 -1.2
Smoking status: Current 0.9 1.4 3.8 -0.1 -1.3 -2.0 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 3.2 1.8 -0.4 0.9 1.3
Whole body water mass 2.3 13.1 46.1 -2.3 -0.8 -6.8 -0.2
Leg predicted mass (right) 1.5 8.1 29.2 -1.8 -0.3 -5.4 0.4
Arm fat mass (left) 0.3 1.2 4.1 -0.4 -0.7 -2.0 0.1
Number of self-reported non-cancer illnesses 0.5 0.9 2.5 0.2 -0.8 -0.7 1.6
Average weekly champagne plus white wine intake 0.9 1.2 3.1 0.3 1.0 1.8 0.8
Miserableness 0.4 0.8 2.9 -0.1 -0.4 -0.1 1.7
Guilty feelings 0.3 0.5 1.3 -1.1 -0.1 0.2 0.8
Wears glasses or contact lenses 1.9 2.1 5.6 0.5 -1.6 -0.1 -2.4
Ever taken oral contraceptive pill 0.2 0.3 0.4 0.4 -0.5 0.6 0.5
Hearing aid user 1.1 1.2 2.1 0.1 -1.5 -1.4 -1.0
Mother’s age at death 1.2 1.5 2.4 0.9 1.5 1.4 1.0
Financial situation satisfaction 0.5 0.6 2.0 -0.7 -0.3 0.1 1.4
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.5 -0.6 -0.4 -0.7 -1.2
Commuting to job workplace: Public transport 1.3 1.5 2.4 0.0 1.5 1.6 1.3
Eye problems/disorders: Glaucoma 1.7 2.0 2.9 -1.2 -1.6 -1.2 -1.7
Medication: Blood pressure 1.2 2.2 4.1 -0.1 1.3 2.0 1.7
Pain type(s) experienced in last month: Hip pain 1.1 1.4 1.9 -1.4 -1.1 -1.1 -1.2
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.3 0.0 0.4 0.5 -0.4
High cholesterol (Self-reported) 0.6 1.0 1.4 1.2 -1.1 1.1 0.3
Medication: Bendroflumethiazide 0.7 1.1 1.3 1.1 -1.0 1.2 0.9
Medication: Paracetamol 0.0 0.0 0.1 -0.0 -0.2 -0.2 0.1
Medication: Lisinopril 0.9 1.2 2.5 -1.6 -0.1 -1.3 0.7
Medication: Atorvastatin 0.7 0.9 2.3 0.2 -1.1 -0.3 -1.5
Illnesses of father: High blood pressure 0.9 1.2 3.1 -1.2 1.7 0.4 -0.2
Alcohol drinker status: Never 0.3 0.3 1.0 1.0 -0.3 -0.3 -0.1
Ever smoked 1.7 3.0 4.8 -2.2 -1.9 -1.0 -1.6
Basal metabolic rate 2.1 11.6 39.9 -2.4 -0.9 -6.3 -0.1
Leg fat percentage (left) 0.2 0.6 1.0 1.0 -0.9 0.2 0.9
Arm fat-free mass (left) 2.5 12.8 46.0 -2.0 -1.1 -6.8 0.1
Number of operations (self-reported) 0.4 0.6 1.0 -0.3 -1.0 -0.6 -1.0
Average weekly beer plus cider intake 0.6 0.9 1.7 -0.1 -1.3 -0.4 -1.3
Irritability 0.2 0.4 0.9 -0.7 -1.0 0.3 0.2
Risk taking 1.1 1.7 4.6 -2.1 -0.1 -0.3 -1.4
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.4 0.2 0.4 0.1 -1.2
Fractured/broken bones in last 5 years 1.1 1.4 3.6 1.9 -0.9 1.1 0.1
Age started oral contraceptive pill 0.4 0.5 1.6 0.2 1.2 0.2 -0.4
Diastolic blood pressure, automated reading 0.4 1.3 3.2 -0.0 -1.8 0.3 -1.3
Ever depressed for a whole week 1.9 2.4 3.5 1.8 -0.5 1.6 1.9
Unable to work because of sickness or disability 0.9 1.1 2.6 -0.6 -0.7 -1.6 -1.1
Commuting to job workplace: Cycle 0.7 0.8 3.0 0.4 -0.1 1.7 0.4
Myopia 0.3 0.4 1.5 -0.3 0.3 1.2 -0.2
Vascular/heart problems diagnosed by doctor 0.8 2.2 3.7 -1.9 -0.7 -1.5 -1.6
Cholesterol lowering medication 0.2 0.3 0.5 -0.6 -0.3 0.3 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 0.9 0.8 -0.6 1.0 0.8
Pain experienced in last month 1.3 2.2 8.1 -0.1 0.7 2.8 0.3
Supplements: Calcium 0.8 0.9 2.1 1.0 -0.2 1.4 -0.6
Basal cell carcinoma (self-reported) 1.5 1.8 3.4 -1.1 -1.4 -0.7 -1.9
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.8 0.9 -0.5 -0.3 0.0
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 0.4 -0.0 0.1 -0.3
Heart disease (siblings) 1.7 2.0 4.3 -0.7 -1.8 -0.3 -2.1
Alcohol drinker status: Previous 0.6 0.6 1.6 0.4 -0.9 0.3 -1.3
Pack years of smoking 0.5 0.7 1.5 -0.4 -1.0 -0.4 -1.2
Impedance of whole body 1.0 4.9 13.3 -0.6 2.5 3.6 0.2
Leg fat mass (left) 0.4 1.5 4.4 -0.2 -1.1 -2.1 0.6
Arm predicted mass (left) 2.4 12.4 44.6 -1.9 -1.1 -6.7 0.2