Hub : Traits :

Birth weight

425 significantly associated models · 133 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 66585659 68152438 2 1 1.5e-07 1.6e-07 1.0e+00 100 WDR78
2 1 154282146 156572984 4 2 2.8e-14 3.6e-14 1.0e+00 100 ADAM15 RIT1
3 1 160851894 162347618 1 1 9.8e-08 2.8e-05 3.5e-01 95 FCGR2B
4 1 204982713 206329620 2 1 1.5e-08 2.0e-07 2.0e-02 80 NUCKS1
5 2 8850817 10394558 5 1 9.2e-15 1.4e-18 1.5e-06 70 ADAM17
6 2 23577270 24978497 1 1 4.1e-07 1.1e-09 2.6e-04 64 FKBP1B
7 2 36778887 38245716 1 1 3.3e-07 4.6e-07 5.0e-05 35 PRKD3
8 2 160095086 161610478 1 1 2.2e-07 1.8e-06 8.6e-02 87 PLA2R1
9 3 52242902 53860103 3 1 4.6e-09 4.1e-08 4.2e-01 98 RFT1
10 3 122306920 123860565 2 1 1.6e-18 3.3e-24 2.5e-11 57 RP11-797D24.4
11 3 141326602 142864702 1 1 1.0e-07 3.2e-07 3.1e-01 96 XRN1
12 3 155695485 157118526 2 1 3.5e-46 7.1e-46 1.0e+00 100 TIPARP
13 3 182655858 184099956 1 1 2.2e-08 1.6e-08 1.0e+00 100 KLHL24
14 4 17104059 18507692 1 1 9.3e-17 5.4e-18 2.0e-04 82 DCAF16
15 4 144758204 146706624 2 1 6.2e-14 4.5e-16 1.0e-04 77 ANAPC10
16 6 34747603 36158878 1 1 9.6e-10 1.1e-12 7.2e-05 69 TEAD3
17 6 87358929 88769878 1 1 4.6e-08 3.7e-07 2.1e-01 94 C6orf163
18 6 108612536 110710018 4 2 2.0e-15 1.2e-15 1.0e+00 100 RP11-425D10.10 SESN1
19 6 129638583 131163098 2 1 1.1e-07 3.2e-08 5.2e-02 88 RP11-73O6.3
20 6 141924760 143456607 1 1 3.9e-10 1.3e-11 1.0e+00 100 GPR126
21 7 2032803 3581391 2 1 1.5e-13 1.1e-13 1.3e-01 96 GNA12
22 7 22946782 24434409 2 1 2.5e-11 9.1e-20 4.1e-10 53 CCDC126
23 7 45255940 46658015 1 1 7.1e-09 4.5e-10 2.0e-03 75 IGFBP3
24 7 72674074 73803303 2 1 2.5e-09 2.7e-09 1.8e-01 95 BCL7B
25 7 106110799 107902091 2 1 2.1e-07 1.7e-06 3.7e-01 96 COG5
26 7 126593467 128425768 1 1 1.4e-10 3.6e-10 2.1e-01 96 SND1
27 8 40811597 42450441 1 1 7.7e-09 1.5e-09 1.0e+00 100 ANK1
28 8 144035121 145286483 1 1 1.4e-08 8.6e-06 3.7e-04 36 ZNF623
29 9 97520168 98975128 1 1 2.5e-13 8.3e-17 1.0e+00 100 PTCH1
30 9 122817066 124681858 5 1 1.9e-09 3.4e-09 1.0e+00 100 RAB14
31 9 124913308 126563910 2 2 9.0e-10 2.0e-12 1.8e-01 96 RABGAP1
32 9 138525778 139943112 1 1 2.3e-08 1.9e-12 1.8e-05 63 GPSM1
33 10 70251287 71665054 1 1 3.1e-07 6.1e-18 3.6e-12 35 SUPV3L1
34 10 93657148 95151622 3 1 9.5e-12 8.3e-13 1.4e-02 88 EIF2S2P3
35 10 101602004 103018321 1 1 2.3e-07 9.8e-06 3.2e-01 95 HIF1AN
36 10 103807817 106042502 9 2 5.3e-14 2.8e-15 1.5e-01 97 C10orf26 CNNM2
37 10 123438113 124889817 1 1 1.0e-09 2.9e-09 1.0e+00 100 PLEKHA1
38 11 1242690 2988323 3 2 5.1e-15 1.4e-12 6.4e-06 59 ASCL2 MRPL23
39 11 64501991 66011280 2 1 4.4e-08 1.7e-07 1.7e-02 79 LTBP3
40 11 68781070 70179848 1 1 2.9e-07 2.9e-07 1.0e+00 100 ORAOV1
41 11 101284459 102802722 2 1 2.1e-08 4.1e-09 1.0e+00 100 RP11-864G5.3
42 11 110776537 112491227 3 1 8.5e-08 4.4e-08 1.9e-02 82 C11orf1
43 12 25789333 27681980 1 1 5.1e-10 5.5e-12 2.8e-03 81 ITPR2
44 12 65930145 67328072 1 1 3.8e-08 1.0e-36 3.9e-30 19 RBMS1P1
45 12 111102574 113517494 11 2 1.7e-10 4.8e-21 4.5e-06 76 ADAM1A HECTD4
46 15 49216723 50623952 1 1 1.5e-07 1.0e-07 2.4e-01 95 DTWD1
47 15 90712555 92135418 2 1 6.0e-10 3.2e-08 8.5e-01 100 FES
48 16 1605051 3015262 1 1 2.0e-07 7.4e-05 2.1e-01 90 RNPS1
49 16 67651879 69084178 1 1 2.8e-07 5.7e-06 1.4e-01 90 PRMT7
50 16 86743421 88216892 1 1 2.3e-07 1.2e-06 9.1e-01 100 ZCCHC14
51 17 1517914 2918626 1 1 1.9e-07 1.7e-07 9.6e-02 90 SRR
52 17 6397773 8215534 16 1 3.3e-30 2.8e-27 3.2e-02 96 ELP5
53 17 25295032 26338912 2 1 1.4e-10 2.1e-11 6.1e-03 83 RP11-173M1.8
54 19 54004939 55427510 2 2 2.1e-09 1.9e-07 1.0e-01 90 CTD-3093M3.1 RPS9
55 20 30578467 32140287 3 2 1.3e-14 3.1e-15 1.0e+00 100 COMMD7 RP5-1085F17.3
56 20 56567724 57961572 1 1 1.4e-07 4.2e-07 4.1e-01 97 STX16-NPEPL1
57 20 61967037 62912463 1 1 3.4e-07 6.6e-07 8.7e-03 72 LINC00176
58 22 28792887 30261219 1 1 4.2e-09 8.7e-09 1.0e+00 100 KREMEN1
59 22 50246695 51219006 1 1 3.5e-07 2.7e-09 6.3e-09 5 LMF2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.21 1 0 0.0 0.00 1.0e+00 PLEKHA1
Crohns Disease (2017) 1.77 4 1 3.0 0.55 4.5e-01 GPSM1 RFT1 RIT1 RPS9
Irritable Bowel Disease (IBD) 1.90 5 1 3.0 0.30 6.3e-01 EIF2S2P3 GNA12 GPSM1 RIT1 TEAD3
Ulcerative Colitis (UC) 1.87 2 1 3.0 0.00 1.0e+00 GNA12 GPSM1
Major Depression (MDD) 1.96 2 0 0.0 0.00 1.0e+00 CNNM2 FES
Reaction Time 1.92 2 1 3.0 0.00 1.0e+00 ELP5 HECTD4
Verbal and Numeric Reasoning (VNR) 1.23 2 1 3.0 0.00 1.0e+00 DCAF16 SND1
Breast Cancer 1.48 4 1 3.0 0.69 3.1e-01 FES LTBP3 RIT1 RP11-73O6.3
Ovarian Cancer 1.24 1 0 0.0 0.00 1.0e+00 PRMT7
Prostate Cancer 2.85 2 1 3.0 0.00 1.0e+00 ADAM15 ASCL2
Body Mass Index (BMI) (2010) 1.40 1 0 0.0 0.00 1.0e+00 CNNM2
Coronary Artery Disease (CAD) 2.45 3 0 0.0 0.00 1.0e+00 CNNM2 DCAF16 HECTD4
Crohns Disease (2012) 1.40 1 0 0.0 0.00 1.0e+00 RIT1
HbA1C 1.85 1 0 0.0 0.00 1.0e+00 ADAM1A
HDL Cholesterol 1.43 2 1 3.0 0.00 1.0e+00 PRMT7 RFT1
LDL Cholesterol 1.44 1 1 3.0 0.00 1.0e+00 HECTD4
Lupus 1.11 1 0 0.0 0.00 1.0e+00 HECTD4
Primary Biliary Cirrhosis 1.36 1 0 0.0 0.00 1.0e+00 HECTD4
Rheumatoid Arthritis 1.22 1 0 0.0 0.00 1.0e+00 FCGR2B
Schizophrenia 1.65 4 2 6.1 0.42 5.8e-01 C10orf26 CNNM2 FES PRMT7
Triglycerides 1.30 1 1 3.0 0.00 1.0e+00 BCL7B
Type 2 Diabetes (T2D) 3.24 4 1 3.0 0.58 4.2e-01 ANK1 EIF2S2P3 PLEKHA1 RFT1
Ulcerative Colitis 1.65 2 0 0.0 0.00 1.0e+00 GNA12 GPSM1
Blood Eosinophil Count 4.43 16 11 33.3 0.43 9.2e-02 ADAM15 ADAM1A C11orf1 C6orf163 EIF2S2P3 ELP5 GNA12 GPSM1 HECTD4 LTBP3 RFT1 RP11-73O6.3 RP5-1085F17.3 SESN1 TEAD3 XRN1
Blood Platelet Count 2.88 14 10 30.3 0.54 4.7e-02 ADAM15 ADAM1A C11orf1 DCAF16 FCGR2B GNA12 HECTD4 LTBP3 ORAOV1 RAB14 RP11-864G5.3 SND1 STX16-NPEPL1 TIPARP
Blood Red Count 2.09 20 12 36.4 0.42 6.6e-02 ADAM15 ADAM1A CNNM2 EIF2S2P3 FCGR2B FKBP1B GNA12 GPR126 HECTD4 ITPR2 KLHL24 LMF2 PRMT7 RABGAP1 RP11-425D10.10 RP11-73O6.3 SESN1 STX16-NPEPL1 TEAD3 TIPARP
Blood White Count 3.40 22 16 48.5 0.53 1.1e-02 ADAM1A C6orf163 CCDC126 CNNM2 DCAF16 FCGR2B FES FKBP1B GNA12 GPSM1 HECTD4 LTBP3 ORAOV1 PLA2R1 PTCH1 RAB14 RFT1 RNPS1 RP11-73O6.3 RP11-864G5.3 TIPARP WDR78
Heel T-Score 2.88 17 11 33.3 0.15 5.7e-01 ANAPC10 CNNM2 DCAF16 ELP5 GNA12 GPR126 IGFBP3 KREMEN1 LINC00176 RABGAP1 RFT1 RNPS1 RP11-173M1.8 RP11-73O6.3 SRR TIPARP XRN1
BMI 1.26 13 7 21.2 -0.60 2.9e-02 ADAM15 ASCL2 CNNM2 DCAF16 ELP5 GPR126 HECTD4 KLHL24 LTBP3 ORAOV1 RIT1 RP11-73O6.3 SRR
Height 6.02 38 32 97.0 -0.72 2.7e-07 ADAM15 ADAM17 ANAPC10 BCL7B C11orf1 CCDC126 COMMD7 DCAF16 FES FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 KLHL24 KREMEN1 NUCKS1 PLEKHA1 PTCH1 RABGAP1 RBMS1P1 RFT1 RNPS1 RP11-173M1.8 RP11-425D10.10 RP11-73O6.3 RP11-797D24.4 RP11-864G5.3 RP5-1085F17.3 RPS9 SESN1 SRR TEAD3 WDR78 XRN1 ZCCHC14
Waist Hip Ratio (WHR) 3.00 13 10 30.3 0.25 4.1e-01 ADAM15 ADAM17 ADAM1A ANAPC10 BCL7B EIF2S2P3 GPSM1 IGFBP3 ORAOV1 PLA2R1 RFT1 RP11-73O6.3 TIPARP
Systolic Blood Pressure 3.92 15 13 39.4 0.35 2.1e-01 ADAM1A C10orf26 C11orf1 CNNM2 COMMD7 DCAF16 ELP5 FES GPR126 HECTD4 LINC00176 PLEKHA1 RABGAP1 SND1 SRR
Smoking Status 1.22 3 1 3.0 0.00 1.0e+00 ADAM1A FES SRR
Allergy or Eczema 2.26 10 4 12.1 0.04 9.2e-01 ADAM15 ADAM1A C11orf1 FES GNA12 HECTD4 RIT1 SESN1 SRR WDR78
Cardiovascular Disease 2.87 11 7 21.2 0.60 5.3e-02 ADAM1A C11orf1 CNNM2 COG5 DCAF16 ELP5 FES HECTD4 KREMEN1 LINC00176 NUCKS1
Hypothyroidism (self reported) 3.74 6 4 12.1 0.33 5.2e-01 ADAM1A C6orf163 HECTD4 PLEKHA1 PRMT7 SESN1
Respiratory disease 1.72 2 1 3.0 0.00 1.0e+00 C11orf1 EIF2S2P3
Type 2 Diabetes (T2D) 3.09 4 2 6.1 0.46 5.4e-01 ADAM1A ANK1 EIF2S2P3 GPSM1
Lung FEV1/FVC ratio 4.93 11 7 21.2 0.29 3.8e-01 ADAM15 DTWD1 FCGR2B GNA12 GPR126 NUCKS1 PLA2R1 PRMT7 PTCH1 RP11-173M1.8 SESN1
Lung FVC 1.65 12 5 15.2 -0.09 7.7e-01 ANAPC10 C6orf163 CCDC126 CNNM2 DCAF16 ELP5 GPSM1 HECTD4 NUCKS1 PTCH1 TEAD3 TIPARP
Neuroticism 1.28 2 2 6.1 0.00 1.0e+00 CNNM2 PTCH1
Chronotype (morning person) 1.17 4 1 3.0 -0.59 4.1e-01 C10orf26 GPSM1 HECTD4 SUPV3L1
Hair Pigment 0.25 7 6 18.2 0.04 9.3e-01 FES HECTD4 MRPL23 NUCKS1 RIT1 RP11-73O6.3 RP5-1085F17.3
Tanning 0.34 6 1 3.0 0.16 7.6e-01 ADAM15 COMMD7 DTWD1 HECTD4 IGFBP3 RP5-1085F17.3
Hand grip strength (left) 2.50 7 3 9.1 0.24 6.0e-01 DCAF16 FES FKBP1B NUCKS1 RFT1 RP11-73O6.3 SND1
Number of treatments/medications taken 1.87 4 0 0.0 -1.00 4.8e-03 ADAM1A DCAF16 HECTD4 NUCKS1
Sensitivity / hurt feelings 1.34 2 1 3.0 0.00 1.0e+00 FES PTCH1
Hearing difficulty/problems: Yes 1.15 1 0 0.0 0.00 1.0e+00 ELP5
Systolic blood pressure, automated reading 2.87 8 5 15.2 -0.33 4.3e-01 C10orf26 C11orf1 CNNM2 DCAF16 ELP5 FES HECTD4 SRR
Angina 1.56 1 1 3.0 0.00 1.0e+00 FES
Medication: Metformin 2.06 1 1 3.0 0.00 1.0e+00 EIF2S2P3
Diabetes (father) 2.16 1 1 3.0 0.00 1.0e+00 EIF2S2P3
Diabetes (mother) 1.91 3 0 0.0 0.00 1.0e+00 ANK1 EIF2S2P3 RP11-797D24.4
Pack years adult smoking proportion 1.16 1 0 0.0 0.00 1.0e+00 RFT1
Impedance of leg (right) 2.59 16 10 30.3 -0.59 1.6e-02 ADAM15 ASCL2 C6orf163 CNNM2 FES FKBP1B GPR126 IGFBP3 LTBP3 ORAOV1 PRKD3 PTCH1 RIT1 RP11-73O6.3 SRR TIPARP
Leg fat-free mass (left) 4.63 28 20 60.6 0.94 3.2e-13 ADAM15 ADAM17 ANAPC10 ASCL2 C6orf163 CCDC126 CNNM2 DCAF16 FES FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 XRN1
Trunk fat percentage 1.35 6 3 9.1 0.66 1.5e-01 GNA12 GPR126 KLHL24 PLEKHA1 SRR TEAD3
Hand grip strength (right) 2.60 7 4 12.1 0.89 7.0e-03 DCAF16 FKBP1B IGFBP3 NUCKS1 PTCH1 RFT1 RP11-73O6.3
Average weekly fortified wine intake 1.05 1 0 0.0 0.00 1.0e+00 RFT1
Maternal smoking around birth 1.18 1 0 0.0 0.00 1.0e+00 RFT1
Fed-up feelings 1.30 3 0 0.0 0.00 1.0e+00 ELP5 FKBP1B HECTD4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.20 1 0 0.0 0.00 1.0e+00 BCL7B
Relative age voice broke 1.07 1 0 0.0 0.00 1.0e+00 ADAM1A
Taking other prescription medications 1.60 2 0 0.0 0.00 1.0e+00 ADAM1A HECTD4
Age when periods started (menarche) 1.17 2 1 3.0 0.00 1.0e+00 RFT1 TIPARP
Heel bone mineral density (BMD) T-score, automated (left) 1.63 2 2 6.1 0.00 1.0e+00 KREMEN1 TIPARP
High blood pressure 2.93 11 6 18.2 -0.57 7.0e-02 ADAM1A C11orf1 CNNM2 DCAF16 ELP5 FES HECTD4 KREMEN1 LINC00176 NUCKS1 SRR
Hayfever, allergic rhinitis or eczema 2.04 5 1 3.0 0.24 6.9e-01 ADAM15 ADAM1A C11orf1 RAB14 WDR78
Stomach or abdominal pain in last month 1.31 1 0 0.0 0.00 1.0e+00 RABGAP1
Medication: Atenolol 2.23 2 2 6.1 0.00 1.0e+00 FES HECTD4
Medication: Levothyroxine sodium 2.90 3 2 6.1 0.00 1.0e+00 ADAM1A HECTD4 PLEKHA1
Sitting height 6.98 27 20 60.6 0.63 4.7e-04 ADAM15 ANAPC10 C6orf163 CCDC126 COMMD7 DCAF16 FKBP1B GNA12 GPR126 GPSM1 HIF1AN IGFBP3 ITPR2 KREMEN1 NUCKS1 PTCH1 RBMS1P1 RFT1 RP11-425D10.10 RP11-73O6.3 RP11-797D24.4 RP5-1085F17.3 TEAD3 TIPARP WDR78 XRN1 ZCCHC14
High blood pressure (mother) 2.11 2 2 6.1 0.00 1.0e+00 CNNM2 FES
Body mass index (BMI) 1.28 9 3 9.1 0.56 1.2e-01 ADAM15 ASCL2 CNNM2 DCAF16 KLHL24 LTBP3 ORAOV1 RP11-73O6.3 SRR
Impedance of leg (left) 2.58 16 10 30.3 -0.85 3.7e-05 ADAM15 ASCL2 C6orf163 CNNM2 FES FKBP1B GPR126 HIF1AN IGFBP3 LTBP3 ORAOV1 PRKD3 PTCH1 RIT1 RP11-73O6.3 SRR
Leg predicted mass (left) 4.60 28 20 60.6 0.94 2.9e-13 ADAM15 ADAM17 ANAPC10 ASCL2 C6orf163 CCDC126 CNNM2 DCAF16 FES FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 XRN1
Trunk fat mass 1.85 9 6 18.2 0.99 7.7e-07 ANAPC10 CNNM2 GNA12 GPR126 KLHL24 PLEKHA1 RNPS1 RP11-73O6.3 SRR
Waist circumference 1.50 8 1 3.0 0.77 2.5e-02 ADAM15 ELP5 GNA12 LTBP3 PLA2R1 PLEKHA1 RNPS1 TIPARP
Number of incorrect matches in round 0.93 1 0 0.0 0.00 1.0e+00 PLEKHA1
Past tobacco smoking 1.26 2 0 0.0 0.00 1.0e+00 ADAM1A SRR
Nervous feelings 1.32 1 1 3.0 0.00 1.0e+00 CNNM2
Frequency of tenseness / restlessness in last 2 weeks 1.13 1 0 0.0 0.00 1.0e+00 CNNM2
Hearing difficulty/problems with background noise 1.17 1 0 0.0 0.00 1.0e+00 NUCKS1
Hair/balding pattern: Pattern 2 1.33 1 0 0.0 0.00 1.0e+00 COMMD7
Forced vital capacity (FVC) 4.03 13 9 27.3 0.81 7.2e-04 ANAPC10 CCDC126 DCAF16 ELP5 FKBP1B GNA12 GPR126 IGFBP3 PTCH1 RFT1 RP11-425D10.10 RP11-73O6.3 TEAD3
Heel bone mineral density (BMD) T-score, automated (right) 1.70 2 2 6.1 0.00 1.0e+00 KREMEN1 TIPARP
Qualifications: None of the above 0.95 1 0 0.0 0.00 1.0e+00 DCAF16
Heart attack 1.69 1 1 3.0 0.00 1.0e+00 FES
Allergy 1.99 6 1 3.0 -0.34 5.0e-01 ADAM1A C11orf1 FES GNA12 SESN1 WDR78
Diabetes (self-reported) 2.39 3 2 6.1 0.00 1.0e+00 ANK1 EIF2S2P3 GPSM1
Medication: Ramipril 1.56 2 0 0.0 0.00 1.0e+00 ADAM1A FES
Medication: Simvastatin 1.64 2 1 3.0 0.00 1.0e+00 DCAF16 FES
Fluid intelligence score 1.23 1 0 0.0 0.00 1.0e+00 DCAF16
Illnesses of siblings 1.63 3 0 0.0 0.00 1.0e+00 ADAM1A FES HECTD4
Neuroticism score 1.03 1 1 3.0 0.00 1.0e+00 PTCH1
Weight 3.17 19 13 39.4 0.95 6.5e-10 ADAM15 ANAPC10 ASCL2 CCDC126 CNNM2 DCAF16 FKBP1B GNA12 GPR126 HECTD4 HIF1AN KLHL24 LTBP3 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RNPS1 RP11-73O6.3
Impedance of arm (right) 1.85 10 6 18.2 -0.17 6.5e-01 ADAM15 ASCL2 GPR126 IGFBP3 KREMEN1 LTBP3 PTCH1 RP11-73O6.3 RP11-864G5.3 TIPARP
Arm fat percentage (right) 1.45 8 4 12.1 0.22 5.9e-01 CNNM2 DCAF16 ELP5 KLHL24 LTBP3 ORAOV1 SRR TEAD3
Trunk fat-free mass 5.39 26 21 63.6 0.90 2.6e-10 ADAM15 ADAM17 ANAPC10 ASCL2 C6orf163 CCDC126 CNNM2 DCAF16 FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 WDR78
Hip circumference 2.79 14 10 30.3 0.97 9.0e-09 ADAM15 ANAPC10 ASCL2 BCL7B CNNM2 GNA12 GPR126 HECTD4 KLHL24 ORAOV1 PLEKHA1 PTCH1 RNPS1 RP11-73O6.3
Father's age at death 1.67 3 1 3.0 0.00 1.0e+00 FES HECTD4 SESN1
Worrier / anxious feelings 1.31 3 1 3.0 0.00 1.0e+00 CNNM2 PTCH1 SND1
Frequency of tiredness / lethargy in last 2 weeks 1.13 1 0 0.0 0.00 1.0e+00 FKBP1B
Forced expiratory volume in 1-second (FEV1) 2.95 10 6 18.2 0.96 1.4e-05 ANAPC10 CCDC126 DCAF16 FKBP1B IGFBP3 PTCH1 RFT1 RP11-425D10.10 RP11-73O6.3 TEAD3
Qualifications: A levels/AS levels or equivalent 0.92 1 0 0.0 0.00 1.0e+00 DCAF16
Asthma 1.74 2 0 0.0 0.00 1.0e+00 C11orf1 EIF2S2P3
Medication: Ibuprofen (e.g. Nurofen) 1.36 1 0 0.0 0.00 1.0e+00 HECTD4
Medication: Cholesterol lowering 1.71 2 1 3.0 0.00 1.0e+00 DCAF16 FES
Depression (self-reported) 1.09 1 0 0.0 0.00 1.0e+00 DTWD1
Illnesses of mother 1.72 1 1 3.0 0.00 1.0e+00 FES
Forced expiratory volume in 1-second (FEV1), Best measure 2.91 10 4 12.1 0.94 5.5e-05 ANAPC10 CCDC126 DCAF16 FKBP1B IGFBP3 PLA2R1 PTCH1 RFT1 RP11-73O6.3 TEAD3
Pulse wave Arterial Stiffness index 1.95 1 1 3.0 0.00 1.0e+00 ADAM1A
Impedance of arm (left) 1.80 13 5 15.2 -0.17 5.7e-01 ADAM15 ASCL2 FKBP1B GNA12 GPR126 HECTD4 KREMEN1 LTBP3 ORAOV1 PTCH1 RP11-73O6.3 RP11-864G5.3 TIPARP
Arm fat mass (right) 1.62 11 5 15.2 0.99 3.0e-09 ADAM15 ASCL2 CNNM2 GNA12 KLHL24 LTBP3 ORAOV1 PLEKHA1 RNPS1 RP11-73O6.3 SRR
Trunk predicted mass 5.40 26 21 63.6 0.90 2.5e-10 ADAM15 ADAM17 ANAPC10 ASCL2 C6orf163 CCDC126 CNNM2 DCAF16 FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 WDR78
Standing height 5.73 28 24 72.7 0.78 1.2e-06 ADAM15 ADAM17 ANAPC10 CCDC126 COMMD7 DCAF16 FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 NUCKS1 PLEKHA1 PTCH1 RABGAP1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-797D24.4 RP5-1085F17.3 TEAD3 WDR78 XRN1 ZCCHC14
Tense / 'highly strung' 1.34 1 0 0.0 0.00 1.0e+00 CNNM2
Hair/balding pattern: Pattern 4 1.03 1 1 3.0 0.00 1.0e+00 SRR
Birth weight of first child 6.51 20 7 21.2 0.94 1.2e-09 ADAM15 ADAM17 ADAM1A ANAPC10 C10orf26 DCAF16 FES HECTD4 IGFBP3 ITPR2 LMF2 PLEKHA1 RP11-797D24.4 RP11-864G5.3 RPS9 SESN1 SND1 SUPV3L1 TEAD3 TIPARP
Peak expiratory flow (PEF) 2.12 7 3 9.1 0.97 2.0e-04 ANAPC10 DCAF16 FKBP1B NUCKS1 RABGAP1 RP11-425D10.10 XRN1
Qualifications: O levels/GCSEs or equivalent 1.01 1 0 0.0 0.00 1.0e+00 NUCKS1
Mouth/teeth dental problems: Bleeding gums 0.97 1 0 0.0 0.00 1.0e+00 SND1
Medication: Paracetamol 1.19 1 0 0.0 0.00 1.0e+00 FKBP1B
Medication for cholesterol, blood pressure or diabetes 2.21 4 1 3.0 0.89 1.1e-01 ADAM1A C11orf1 DCAF16 FES
Gout (self-reported) 1.27 2 0 0.0 0.00 1.0e+00 ADAM15 HECTD4
Hypothyroidism/myxoedema (self-reported) 3.14 6 2 6.1 -0.31 5.4e-01 ADAM1A C6orf163 HECTD4 PLEKHA1 PRMT7 SESN1
Medication: Amlodipine 1.44 1 1 3.0 0.00 1.0e+00 FES
High blood pressure (siblings) 1.68 2 1 3.0 0.00 1.0e+00 FES HECTD4
Forced vital capacity (FVC), Best measure 3.88 11 8 24.2 0.95 4.9e-06 ANAPC10 CCDC126 DCAF16 FKBP1B GNA12 GPR126 IGFBP3 PTCH1 RFT1 RP11-73O6.3 TEAD3
Body fat percentage 1.25 5 2 6.1 -0.57 3.1e-01 DCAF16 KLHL24 LTBP3 SRR TEAD3
Leg fat percentage (right) 1.35 5 2 6.1 -0.68 2.1e-01 DCAF16 FKBP1B IGFBP3 LTBP3 TEAD3
Arm fat-free mass (right) 4.69 25 20 60.6 0.89 2.0e-09 ADAM15 ADAM17 ANAPC10 ASCL2 CCDC126 CNNM2 DCAF16 FKBP1B GNA12 GPR126 GPSM1 HECTD4 IGFBP3 LTBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-864G5.3 TEAD3
Comparative body size at age 10 1.99 8 3 9.1 0.97 5.8e-05 KLHL24 LTBP3 ORAOV1 PLA2R1 RIT1 SRR SUPV3L1 WDR78
Wheeze or whistling in the chest in last year 1.69 2 1 3.0 0.00 1.0e+00 C11orf1 XRN1
Age at first live birth 1.18 1 0 0.0 0.00 1.0e+00 DCAF16
Pulse wave peak to peak time 1.89 1 1 3.0 0.00 1.0e+00 ADAM1A
Qualifications: College or University degree 1.16 5 3 9.1 -0.08 9.0e-01 C6orf163 DCAF16 FKBP1B RP11-864G5.3 SND1
Neck or shoulder pain in last month 1.20 1 0 0.0 0.00 1.0e+00 COMMD7
Medication: Blood pressure 2.52 6 1 3.0 -0.60 2.1e-01 ADAM1A C11orf1 DCAF16 ELP5 FES HECTD4
Angina (self-reported) 1.56 1 1 3.0 0.00 1.0e+00 FES
Medication: Allopurinol 1.30 1 0 0.0 0.00 1.0e+00 ADAM15
Medication: Seretide 50 evohaler 1.34 1 0 0.0 0.00 1.0e+00 PRMT7
Mean time to correctly identify matches 2.10 3 1 3.0 0.00 1.0e+00 ELP5 HECTD4 RP11-73O6.3
Whole body fat mass 1.67 11 3 9.1 0.98 1.7e-07 ADAM15 ANAPC10 CNNM2 GNA12 GPR126 KLHL24 LTBP3 PLEKHA1 RNPS1 RP11-73O6.3 SRR
Leg fat mass (right) 1.37 8 3 9.1 0.99 7.9e-06 ADAM15 ASCL2 CNNM2 GNA12 HECTD4 KLHL24 LTBP3 RP11-73O6.3
Arm predicted mass (right) 4.71 25 20 60.6 0.89 1.7e-09 ADAM15 ADAM17 ANAPC10 ASCL2 CCDC126 CNNM2 DCAF16 FKBP1B GNA12 GPR126 GPSM1 HECTD4 IGFBP3 LTBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-864G5.3 TEAD3
Pulse rate, automated reading 1.21 4 1 3.0 0.52 4.8e-01 C11orf1 HIF1AN RFT1 RP11-864G5.3
Alcohol intake frequency. 0.87 1 0 0.0 0.00 1.0e+00 FKBP1B
Comparative height size at age 10 4.89 23 17 51.5 0.89 9.2e-09 ADAM15 ADAM17 ANAPC10 CCDC126 DCAF16 FKBP1B GNA12 GPR126 GPSM1 HECTD4 IGFBP3 KLHL24 NUCKS1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP5-1085F17.3 TEAD3 WDR78
Chest pain or discomfort 1.13 1 0 0.0 0.00 1.0e+00 ELP5
Age at last live birth 1.26 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Family relationship satisfaction 1.44 1 0 0.0 0.00 1.0e+00 RP11-73O6.3
Medication: Aspirin 1.84 1 1 3.0 0.00 1.0e+00 FES
Hypertension (Self-reported) 2.88 11 5 15.2 -0.57 6.9e-02 ADAM1A C11orf1 CNNM2 DCAF16 ELP5 FES HECTD4 KREMEN1 LINC00176 NUCKS1 SRR
Illnesses of father: Heart disease 1.81 1 1 3.0 0.00 1.0e+00 FES
Illnesses of siblings: Diabetes 1.74 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Smoking status: Previous 1.18 1 0 0.0 0.00 1.0e+00 HECTD4
Forced expiratory volume in 1-second (FEV1), predicted 4.36 9 5 15.2 0.96 2.6e-05 ANAPC10 DCAF16 GNA12 GPR126 GPSM1 PTCH1 RFT1 RP11-73O6.3 TEAD3
Whole body fat-free mass 5.15 28 21 63.6 0.90 4.7e-11 ADAM15 ADAM17 ANAPC10 ASCL2 C6orf163 CCDC126 CNNM2 DCAF16 FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3 WDR78
Leg fat-free mass (right) 4.72 27 20 60.6 0.94 5.0e-13 ADAM15 ADAM17 ANAPC10 ASCL2 C6orf163 CCDC126 CNNM2 DCAF16 FES FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3
Arm fat percentage (left) 1.39 7 4 12.1 0.07 8.8e-01 CNNM2 DCAF16 KLHL24 LTBP3 PLEKHA1 SRR TEAD3
Diabetes diagnosed by doctor 2.49 3 2 6.1 0.00 1.0e+00 ANK1 EIF2S2P3 GPSM1
Mouth/teeth dental problems: Mouth ulcers 0.98 2 0 0.0 0.00 1.0e+00 DTWD1 STX16-NPEPL1
Medication for cholesterol 2.03 2 0 0.0 0.00 1.0e+00 FES HECTD4
Asthma (self-reported) 1.69 2 0 0.0 0.00 1.0e+00 C11orf1 EIF2S2P3
Osteoarthritis (self-reported) 1.37 1 0 0.0 0.00 1.0e+00 NUCKS1
Medication: Aspirin 1.89 1 1 3.0 0.00 1.0e+00 FES
Illnesses of father: None of the above (group 1) 2.05 1 1 3.0 0.00 1.0e+00 FES
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.39 1 0 0.0 0.00 1.0e+00 GPR126
Whole body water mass 5.14 27 20 60.6 0.93 1.2e-12 ADAM15 ADAM17 ANAPC10 ASCL2 C6orf163 CCDC126 CNNM2 DCAF16 FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3
Leg predicted mass (right) 4.72 27 19 57.6 0.94 5.1e-13 ADAM15 ADAM17 ANAPC10 ASCL2 C6orf163 CCDC126 CNNM2 DCAF16 FES FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3
Arm fat mass (left) 1.60 11 5 15.2 0.99 2.7e-09 ADAM15 ASCL2 CNNM2 GNA12 KLHL24 LTBP3 ORAOV1 PLEKHA1 RNPS1 RP11-73O6.3 SRR
Number of self-reported non-cancer illnesses 1.49 1 0 0.0 0.00 1.0e+00 HECTD4
Miserableness 0.83 1 0 0.0 0.00 1.0e+00 FKBP1B
Guilty feelings 1.25 2 0 0.0 0.00 1.0e+00 FKBP1B PTCH1
Medication: Blood pressure 2.49 4 3 9.1 -0.98 2.0e-02 C11orf1 CNNM2 FES HECTD4
High cholesterol (Self-reported) 1.29 1 0 0.0 0.00 1.0e+00 DCAF16
Medication: Bendroflumethiazide 1.70 2 1 3.0 0.00 1.0e+00 C11orf1 FES
Medication: Paracetamol 1.21 1 0 0.0 0.00 1.0e+00 FKBP1B
Illnesses of father: High blood pressure 1.74 1 1 3.0 0.00 1.0e+00 FES
Ever smoked 1.18 1 1 3.0 0.00 1.0e+00 SRR
Basal metabolic rate 4.75 27 19 57.6 0.93 1.1e-12 ADAM15 ADAM17 ANAPC10 ASCL2 C6orf163 CCDC126 CNNM2 DCAF16 FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 KLHL24 LTBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 TEAD3
Leg fat percentage (left) 1.30 3 2 6.1 0.00 1.0e+00 DCAF16 LTBP3 TEAD3
Arm fat-free mass (left) 4.54 26 19 57.6 0.89 7.6e-10 ADAM15 ADAM17 ANAPC10 ASCL2 CCDC126 CNNM2 DCAF16 FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 LTBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-864G5.3 TEAD3
Number of operations (self-reported) 1.43 1 0 0.0 0.00 1.0e+00 CCDC126
Irritability 1.26 2 0 0.0 0.00 1.0e+00 PTCH1 RP11-73O6.3
Fractured/broken bones in last 5 years 1.36 1 0 0.0 0.00 1.0e+00 PLEKHA1
Diastolic blood pressure, automated reading 2.38 7 6 18.2 -0.44 3.2e-01 ADAM1A CNNM2 DCAF16 ELP5 FES HECTD4 SRR
Vascular/heart problems diagnosed by doctor 3.11 11 6 18.2 0.81 2.4e-03 ADAM1A C11orf1 CNNM2 DCAF16 FES HECTD4 KREMEN1 LINC00176 NUCKS1 SRR TEAD3
Cholesterol lowering medication 1.29 1 0 0.0 0.00 1.0e+00 DCAF16
Pain experienced in last month 0.98 1 0 0.0 0.00 1.0e+00 HECTD4
Heart attack/myocardial infarction (self-reported) 1.73 1 1 3.0 0.00 1.0e+00 FES
Heart disease (siblings) 1.35 1 0 0.0 0.00 1.0e+00 FES
Impedance of whole body 2.12 13 9 27.3 -0.74 3.9e-03 ADAM15 ADAM1A ASCL2 C6orf163 CNNM2 FKBP1B GPR126 IGFBP3 KREMEN1 LTBP3 ORAOV1 PTCH1 RP11-73O6.3
Leg fat mass (left) 1.41 8 3 9.1 0.99 4.9e-06 ADAM15 ASCL2 CNNM2 GNA12 HECTD4 KLHL24 LTBP3 RP11-73O6.3
Arm predicted mass (left) 4.50 26 17 51.5 0.89 8.7e-10 ADAM15 ADAM17 ANAPC10 ASCL2 CCDC126 CNNM2 DCAF16 FKBP1B GNA12 GPR126 GPSM1 HECTD4 HIF1AN IGFBP3 LTBP3 NUCKS1 ORAOV1 PLEKHA1 PTCH1 RBMS1P1 RFT1 RNPS1 RP11-425D10.10 RP11-73O6.3 RP11-864G5.3 TEAD3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 16 0.458 2.22
GTEx Adipose Visceral Omentum 8 0.393 2.22
GTEx Adrenal Gland 7 0.480 2.26
GTEx Artery Aorta 15 0.504 2.25
GTEx Artery Coronary 7 0.592 2.35
GTEx Artery Tibial 12 0.319 2.28
GTEx Brain Caudate basal ganglia 4 0.435 2.17
GTEx Brain Cerebellar Hemisphere 4 0.269 2.20
GTEx Brain Cerebellum 3 0.151 2.17
GTEx Brain Cortex 3 0.290 2.11
GTEx Brain Frontal Cortex BA9 4 0.433 2.20
GTEx Brain Hippocampus 4 0.763 2.24
GTEx Brain Hypothalamus 1 0.169 1.97
GTEx Brain Nucleus accumbens basal ganglia 2 0.231 2.23
GTEx Brain Putamen basal ganglia 3 0.481 2.22
GTEx Breast Mammary Tissue 7 0.355 2.20
GTEx Breast Mammary Tissue (Male) 6 0.503 2.21
GTEx Breast Mammary Tissue (Female) 3 0.182 2.04
GTEx Cells EBV-transformed lymphocytes 3 0.211 2.17
GTEx Cells Transformed fibroblasts 15 0.357 2.11
GTEx Colon Sigmoid 6 0.410 2.36
GTEx Colon Transverse 8 0.388 2.21
GTEx Esophagus Gastroesophageal Junction 6 0.415 2.31
GTEx Esophagus Mucosa 11 0.331 2.23
GTEx Esophagus Muscularis 13 0.402 2.25
GTEx Heart Atrial Appendage 5 0.317 2.18
GTEx Heart Left Ventricle 4 0.261 2.20
GTEx Liver 4 0.558 2.30
GTEx Lung 8 0.278 2.24
GTEx Muscle Skeletal 11 0.381 2.26
GTEx Nerve Tibial 15 0.347 2.21
GTEx Ovary 3 0.330 2.13
GTEx Pancreas 5 0.306 2.25
GTEx Pituitary 3 0.269 2.29
GTEx Prostate 6 0.719 2.28
GTEx Skin Not Sun Exposed Suprapubic 7 0.285 2.32
GTEx Skin Sun Exposed Lower leg 16 0.440 2.30
GTEx Small Intestine Terminal Ileum 4 0.868 2.32
GTEx Spleen 10 0.709 2.28
GTEx Stomach 7 0.481 2.35
GTEx Testis 13 0.412 2.29
GTEx Thyroid 13 0.325 2.18
GTEx Uterus 1 0.176 2.12
GTEx Vagina 4 0.630 2.07
GTEx Whole Blood 6 0.301 2.26
METSIM Adipose 19 0.412 2.14
NTR Blood 13 0.541 2.29
ROSMAP Brain Pre-frontal Cortex 17 0.387 2.16
YFS Blood 17 0.368 2.09
CommonMind Brain Pre-frontal Cortex 16 0.298 2.09
TCGA Breast Tumor 1 0.130 2.37
TCGA Breast Normal 14 0.333 2.08
TCGA Ovarian Tumor 4 0.137 1.80
TCGA Prostate Tumor 8 0.231 2.10