TWAS hub - AUTS2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.2950	0.1080	1.9e-03	0.114	NA	-0.005	NA	0.031	3.7e-04	NA	4.7e-01	NA	4.5e-02
2	GTEx	Muscle Skeletal	0.1624	0.0483	1.5e-03	0.133	NA	0.127	NA	0.126	5.3e-13	NA	2.0e-12	NA	2.4e-12
3	GTEx	Nerve Tibial	0.2099	0.0629	1.7e-03	0.058	NA	0.148	NA	0.165	6.2e-05	NA	1.3e-10	NA	9.7e-12
4	GTEx	Skin Not Sun Exposed Suprapubic	0.3060	0.0800	8.2e-04	0.220	NA	0.126	NA	0.186	2.8e-12	NA	2.2e-07	NA	1.8e-10
5	GTEx	Skin Sun Exposed Lower leg	0.1960	0.0430	8.1e-07	0.139	NA	0.113	NA	0.154	1.5e-11	NA	1.3e-09	NA	9.1e-13
6	METSIM	Adipose	0.0557	0.0233	6.8e-03	0.036	0.018	0.021	0.024	0.032	3.9e-06	7.5e-04	3.6e-04	1.5e-04	1.0e-05
7	YFS	Blood	0.2037	0.0304	0.0e+00	0.039	0.089	0.121	0.114	0.107	8.6e-13	1.7e-27	2.3e-37	3.8e-35	4.4e-33

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Illnesses of father: None of the above (group 1)	6.2	7.7	11.2	-2.6	-3.0	-2.4	-3.3	-3.1	-2.7	2.0
Unable to work because of sickness or disability	3.6	4.7	7.1	-0.4	-2.6	-2.6	-2.5	-2.4	-2.7	-0.0
Serious illness, injury or assault to yourself	3.3	4.0	6.4	2.2	-1.9	-2.4	-1.6	-1.8	-2.5	1.2
Illnesses of mother	2.9	3.6	10.0	-3.2	1.4	1.4	1.9	1.9	2.0	0.2
Osteoporosis (self-reported)	2.8	3.4	6.6	0.7	-2.6	-2.0	-2.2	-1.9	-2.1	-0.6
Primary Biliary Cirrhosis	2.7	3.8	6.2	0.6	-2.1	-1.2	-2.4	-2.5	-2.4	-1.8
Medication: Omeprazole	2.7	3.3	5.4	0.2	2.3	0.7	2.2	2.1	2.3	1.5
Worry (Nagel 2018)	2.6	5.5	8.4	2.2	2.4	1.9	2.9	2.9	2.7	0.7
Body Mass Index (BMI) (2010)	2.6	3.6	6.8	1.7	-2.6	-2.5	-1.7	-1.6	-1.9	0.7
Alcohol usually taken with meals	2.6	4.1	5.6	1.9	-2.0	-1.4	-2.2	-2.1	-2.1	-2.4
Hair/balding pattern: Pattern 4	2.6	6.3	33.6	-5.8	-1.6	-1.6	-1.5	-1.3	-1.1	0.0
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	5.6	0.2	2.3	0.8	2.4	2.1	2.1	1.1
Illnesses of father: Heart disease	2.5	3.4	5.9	2.4	2.2	1.8	1.7	1.8	1.8	0.2
Medication: Seretide 50 evohaler	2.4	2.8	5.8	-1.1	1.4	1.4	2.4	2.4	1.8	0.0
Crohns Disease (2012)	2.3	3.8	7.0	-1.2	1.8	2.7	2.0	2.1	2.3	-1.0
High blood pressure (mother)	2.3	3.2	17.0	4.1	-0.6	-0.8	-1.1	-1.0	-1.3	0.7
Ever had bowel cancer screening	2.3	2.7	4.0	1.7	1.9	2.0	1.9	1.6	1.4	-0.4
Pulse wave reflection index	2.2	2.7	7.7	-0.5	1.2	2.7	-1.1	-1.2	-0.4	-2.8
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	5.8	-1.6	1.5	1.2	2.4	1.8	1.5	0.3
Supplements: Calcium	2.1	2.3	5.0	-2.2	-1.5	-2.2	-1.1	-1.1	-1.3	0.4
Worrier / anxious feelings	2.0	3.8	6.7	1.8	2.6	2.0	2.2	2.1	1.8	0.2
Overall health rating	2.0	4.4	21.3	4.6	-1.5	-1.4	-0.6	-0.8	-1.4	1.4
Long-standing illness, disability or infirmity	2.0	3.1	7.1	0.0	-2.0	-2.7	-1.9	-1.8	-1.9	0.4
Heart disease (siblings)	1.9	2.3	4.8	-1.3	2.2	1.7	1.1	1.3	1.9	-0.6
Hearing difficulty/problems: Yes	1.8	2.7	6.6	2.6	-2.0	-0.6	-1.3	-1.5	-1.9	0.1
Diabetes (mother)	1.8	2.3	6.5	2.5	-0.5	-1.6	-1.6	-1.5	-1.5	-0.2
Hair/balding pattern: Pattern 2	1.8	2.3	7.1	2.7	1.4	1.4	1.7	1.3	0.8	-0.1
Mouth/teeth dental problems: Dentures	1.8	3.0	4.7	-0.1	1.8	1.9	2.2	2.0	2.1	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	5.4	-0.0	2.3	1.3	1.8	1.8	2.1	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.3	-0.1	-1.3	-1.6	-1.8	-1.7	-1.5	1.4
Guilty feelings	1.8	2.7	4.6	-1.4	1.4	0.2	2.1	2.0	1.5	1.9
Supplements: Fish oil (including cod liver oil)	1.8	2.4	6.2	-2.5	0.2	2.2	-0.8	-1.3	-0.8	-1.7
Irritability	1.8	3.0	7.1	-1.3	-1.8	-2.7	-1.9	-1.8	-1.5	-0.4
Schizophrenia (2014)	1.7	3.7	6.0	2.5	2.0	1.3	2.3	2.1	2.2	-0.1
Nervous feelings	1.7	3.1	7.1	2.7	1.5	1.1	2.0	1.7	1.3	1.5
Hair/balding pattern: Pattern 3	1.7	2.6	13.9	-3.7	-0.6	1.1	-0.8	-0.8	-0.7	-0.7
Medication: Cholesterol lowering	1.7	2.6	5.5	-0.1	-0.4	-1.5	-2.0	-2.3	-2.3	1.3
Qualifications: None of the above	1.6	3.4	8.1	0.1	1.6	1.1	2.1	1.9	1.9	2.9
Depression (self-reported)	1.6	1.9	4.5	0.4	1.2	1.2	2.1	1.9	1.5	0.1
Neuroticism (Nagel 2018)	1.5	3.5	5.8	1.1	2.2	1.1	2.4	2.4	2.3	0.9
HbA1C	1.5	1.7	3.6	1.9	1.8	1.8	0.4	0.3	0.6	-1.0
Smoking status: Previous	1.5	2.2	4.2	-1.7	1.9	2.1	1.4	1.0	1.4	-0.2
Reaction Time	1.4	2.6	4.4	1.4	-1.5	-1.2	-2.1	-2.1	-2.0	0.2
Chronic bronchitis/emphysema (father)	1.4	1.6	5.0	-2.2	1.2	0.1	1.6	1.2	1.0	0.1
Pulse wave Arterial Stiffness index	1.4	1.7	6.4	0.1	1.5	2.5	0.3	0.2	0.7	-1.5
Pulse wave peak to peak time	1.4	1.6	6.1	-0.6	-1.5	-2.5	-0.2	-0.0	-0.5	1.5
Migraine (self-reported)	1.4	1.7	10.8	3.3	0.1	-0.0	0.5	0.2	-0.2	-1.0
Illnesses of siblings: Diabetes	1.4	1.7	3.5	1.3	1.9	1.9	1.1	1.0	1.1	0.0
Mineral and other dietary supplements	1.4	1.9	5.4	2.2	-1.0	-2.3	0.1	0.5	0.3	1.3
Average weekly beer plus cider intake	1.4	2.1	11.4	-3.4	-0.4	-0.6	-0.1	-0.1	0.2	1.6
Ever depressed for a whole week	1.4	1.7	3.5	0.8	1.9	1.4	1.3	1.3	1.6	0.1
Triglycerides	1.3	2.2	3.0	-1.2	-1.6	-0.8	-1.5	-1.7	-1.7	-1.6
Relative age voice broke	1.3	1.9	7.1	2.7	1.0	1.3	0.7	0.5	0.4	-1.6
Multivitamins +/- minerals	1.3	1.7	6.0	-2.5	1.1	2.0	0.1	0.1	0.4	-0.6
Hearing difficulty/problems with background noise	1.3	2.1	13.0	3.6	-0.2	0.8	-0.1	-0.4	-0.7	-0.6
Medication: Ramipril	1.3	1.7	5.6	1.7	1.0	0.2	0.5	0.6	1.2	2.4
Commuting to job workplace: Cycle	1.3	1.6	3.9	2.0	-0.7	-0.9	-1.7	-1.3	-1.0	-0.6
Age at First Birth	1.2	1.7	4.0	-0.3	-1.4	-0.9	-2.0	-1.6	-1.4	-1.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	4.3	-0.0	-2.1	-1.9	-0.6	-0.7	-1.3	-0.3
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.6	-0.0	0.3	-0.9	1.4	1.5	1.2	1.6
Lung cancer (father)	1.2	1.4	5.5	-1.2	0.1	-0.3	1.4	0.9	0.5	2.4
Gout (self-reported)	1.2	1.7	3.6	-0.3	1.3	0.7	1.8	1.9	1.4	0.5
Alcohol intake frequency.	1.2	2.9	17.4	4.2	-0.3	0.8	-0.1	0.1	-0.1	-1.4
Eye problems/disorders: Glaucoma	1.2	1.5	2.4	-0.8	-1.3	-1.4	-1.6	-1.3	-1.4	-0.2
Illnesses of father: High blood pressure	1.2	1.5	3.2	1.0	1.8	1.5	1.2	1.1	0.8	-1.0
Alcohol drinker status: Never	1.2	1.4	7.4	2.7	-1.0	-0.3	-0.7	-0.5	-0.2	-0.9
Crohns Disease (2017)	1.1	2.3	6.2	0.1	1.9	2.5	1.5	1.4	1.5	-0.4
Coronary Artery Disease (CAD)	1.1	1.3	2.6	0.6	-1.1	0.3	-1.5	-1.6	-1.4	-0.8
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.2	1.7	0.6	-0.9	0.8	0.8	0.8	1.8
Pack years adult smoking proportion	1.1	1.6	3.9	-2.0	-0.3	-1.6	-0.4	-0.7	-1.4	1.6
Medication: Levothyroxine sodium	1.1	1.9	3.1	-1.3	-1.1	0.4	-1.8	-1.7	-1.5	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	4.8	-1.9	1.1	2.2	1.2	1.0	1.2	-2.0
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.1	1.0	0.7	-0.1	1.4	1.4	1.4	1.3
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	6.8	2.6	0.0	1.1	0.7	0.6	0.4	-1.0
Exposure to tobacco smoke at home	1.1	1.3	3.8	-1.5	1.4	1.9	0.7	0.5	0.5	-0.2
Loud music exposure frequency	1.1	1.2	2.0	-1.3	-1.4	-1.4	-0.8	-0.6	-0.7	-1.1
Number of full brothers	1.1	1.4	2.8	0.4	-1.5	-1.4	-1.7	-1.4	-0.9	-0.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.9	0.6	-1.1	-0.8	-1.6	-1.7	-1.1	0.6
Supplements: Vitamin C	1.1	1.2	3.3	-0.5	1.0	1.8	1.0	1.1	1.3	0.3
Risk taking	1.1	1.7	8.8	-3.0	-0.8	-0.8	-0.7	-0.6	-0.7	0.5
Schizophrenia (2018)	1.0	2.1	7.2	2.7	1.2	1.4	0.7	0.7	1.1	-1.4
Respiratory disease	1.0	2.3	5.4	-0.8	-1.8	-0.6	-1.4	-1.3	-1.5	-2.3
Neuroticism	1.0	2.5	5.3	-0.1	1.8	1.1	1.9	2.0	2.3	0.1
Ever had hysterectomy (womb removed)	1.0	1.1	2.7	-1.2	1.6	0.4	0.7	0.6	0.7	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	5.9	-0.8	0.9	2.4	1.2	1.2	1.4	-2.0
Headache pain in last month	1.0	1.8	6.2	2.5	-0.2	1.4	1.0	0.8	0.5	-1.6
Pack years of smoking	1.0	1.4	3.7	-1.9	0.1	-1.3	-0.3	-0.6	-1.2	1.7
Schizophrenia vs Biploar Disorder	0.9	1.2	3.1	1.8	0.8	0.1	0.8	1.0	1.2	1.2
Alzheimer’s Disease (in mother)	0.9	1.0	3.4	-1.9	0.5	0.7	-0.0	-0.1	0.0	-1.7
Rheumatoid Arthritis	0.9	1.2	4.1	0.6	-0.9	1.5	-0.6	-0.6	-0.4	-2.0
Type 2 Diabetes (T2D) (2018)	0.9	1.6	6.7	0.3	0.8	-1.1	-1.0	-1.1	-0.7	2.6
Relative age of first facial hair	0.9	1.8	11.4	3.4	-0.1	-0.9	0.3	0.2	-0.2	0.2
Maternal smoking around birth	0.9	1.4	8.4	-2.9	-0.1	-0.4	0.2	-0.3	-0.6	-0.7
Past tobacco smoking	0.9	1.6	3.5	1.9	-1.2	-1.9	-1.0	-0.7	-0.9	0.7
Pain all over the body in last month	0.9	1.0	2.0	1.1	-1.4	-1.2	-0.7	-0.5	-0.9	0.8
Diabetes (self-reported)	0.9	1.4	4.0	0.2	0.4	-1.2	-1.3	-1.3	-0.8	2.0
Medication: Simvastatin	0.9	1.3	2.7	1.3	0.2	-0.7	-1.1	-1.4	-1.6	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	9.2	3.0	-0.3	0.0	0.7	0.6	0.1	-0.2
Number of live births	0.9	1.2	2.5	1.6	1.0	0.7	1.3	0.9	0.3	1.4
Length of working week for main job	0.9	1.0	2.2	-1.5	-0.2	-1.3	-1.0	-0.6	-0.4	1.3
Breastfed as a baby	0.9	1.1	2.1	-0.0	1.0	0.9	1.4	1.4	1.2	-0.5
Suffer from ‘nerves’	0.9	1.3	6.0	2.4	1.0	1.2	0.5	0.5	0.7	0.1
Eye problems/disorders: Cataract	0.9	1.0	3.4	1.8	0.9	1.6	-0.1	-0.6	-0.4	0.3
Ever taken oral contraceptive pill	0.9	1.0	4.3	-2.1	-0.7	0.1	-0.7	-0.6	-0.5	-1.1
High cholesterol (Self-reported)	0.9	1.5	4.0	0.6	0.3	-1.0	-0.8	-1.4	-1.7	2.0
Intelligence (Savage-Jansen 2018)	0.8	2.4	9.2	-3.0	0.7	0.9	0.8	1.2	1.3	-1.6
Breast Cancer	0.8	1.8	6.3	-2.5	-1.3	-0.5	-1.2	-1.2	-1.4	-0.2
Bipolar Disorder (2011)	0.8	0.8	1.5	0.2	1.0	1.0	0.7	0.9	1.2	0.9
Fasting Glucose	0.8	0.9	1.9	-0.3	0.9	0.8	1.4	1.4	1.1	0.0
Waist Hip Ratio (WHR)	0.8	3.5	7.6	-0.8	1.6	1.2	2.8	2.5	2.4	-0.1
Leg fat-free mass (left)	0.8	4.3	9.9	0.2	-2.1	-0.8	-3.1	-2.9	-2.2	-1.5
Supplements: Glucosamine	0.8	1.0	3.1	-1.8	1.3	0.6	0.1	0.2	0.8	1.1
Impedance of leg (left)	0.8	3.9	7.6	-2.3	0.6	-1.5	2.8	2.5	1.5	2.0
Leg predicted mass (left)	0.8	4.4	10.0	0.2	-2.1	-0.7	-3.2	-2.9	-2.2	-1.6
Happiness	0.8	0.9	5.7	2.4	-0.4	0.4	0.4	0.1	-0.4	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	4.3	0.7	0.4	0.6	0.3	0.6	0.6	-2.1
Prospective memory result	0.8	1.0	2.5	-0.6	-0.7	-0.3	-1.4	-1.6	-1.1	0.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	4.2	-0.2	-1.3	-0.9	-1.1	-0.6	-0.9	-2.0
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	3.2	0.3	-0.2	0.8	1.0	1.4	1.6	-1.8
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	4.4	-2.1	-1.3	-0.2	-1.1	-1.1	-1.3	-0.7
Health satisfaction	0.8	1.1	1.6	1.1	-1.3	-1.1	-1.1	-1.1	-1.1	-0.3
Mean time to correctly identify matches	0.8	1.5	3.2	1.3	-0.8	-0.0	-1.5	-1.7	-1.8	0.1
Wears glasses or contact lenses	0.8	0.9	2.0	0.6	0.7	-0.1	1.4	1.4	1.0	0.7
Bipolar Disorder (2018)	0.7	1.0	2.4	-1.5	0.9	0.5	1.3	0.9	0.8	0.8
Bipolar Disorder or Schizophrenia	0.7	1.6	2.2	1.2	1.5	1.4	1.4	1.1	1.3	-0.7
Verbal and Numeric Reasoning (VNR)	0.7	1.8	4.8	-2.2	0.7	0.7	1.4	1.5	1.4	-0.6
Prostate Cancer	0.7	0.9	3.9	2.0	0.7	0.3	0.9	0.8	0.2	0.7
Lupus	0.7	1.0	2.0	-1.1	1.4	0.8	1.3	1.0	0.8	-0.1
Sensitivity / hurt feelings	0.7	1.2	2.8	-1.4	1.7	1.1	0.7	0.8	0.9	-0.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.0	-0.5	-0.0	-0.8	-0.3	-0.7	-1.4	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.7	-0.1	-1.3	-1.6	-0.7	-0.5	-0.6	1.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	3.5	0.5	0.6	-0.2	0.8	0.7	0.6	1.9
Mouth/teeth dental problems	0.7	1.1	2.2	-0.1	-1.1	-0.3	-1.5	-1.4	-1.4	-0.7
Time employed in main current job	0.7	0.8	1.9	-1.4	0.9	0.3	0.9	0.4	0.3	1.3
Blood clot in the leg (DVT)	0.7	0.9	3.1	0.6	-0.4	-1.8	0.2	0.3	-0.0	1.6
Eye problems/disorders: None of the above	0.7	0.8	1.9	0.5	-0.3	-0.6	1.0	1.3	1.4	-0.2
Heart disease (mother)	0.7	0.8	1.1	1.0	-1.0	-1.0	-0.8	-0.8	-0.9	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	4.5	-2.1	0.6	0.4	0.7	0.5	0.2	0.4
Had major operations	0.7	0.8	2.0	1.4	1.1	0.9	0.9	0.7	0.6	0.2
Loneliness, isolation	0.7	1.0	2.4	-0.2	-1.2	-1.2	-0.4	-0.6	-1.1	1.6
Diabetes diagnosed by doctor	0.7	1.2	3.6	1.3	1.1	-0.6	-0.8	-0.9	-0.6	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.3	-0.3	-0.9	-0.5	-1.1	-1.1	-1.0	-0.6
Qualifications: nursing, teaching	0.7	1.1	1.7	0.7	-1.3	-1.2	-0.9	-0.9	-1.2	-0.9
Leg predicted mass (right)	0.7	3.5	7.9	-0.2	-1.9	-0.5	-2.8	-2.6	-2.0	-1.5
Medication: Blood pressure	0.7	1.3	3.6	1.1	1.3	1.9	0.7	0.7	1.0	-0.9
Number of operations (self-reported)	0.7	1.1	1.7	0.4	1.3	0.7	1.3	1.2	1.3	0.4
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.8	1.3	0.1	0.0	-0.6	-0.9	-1.1	-1.2
Age started oral contraceptive pill	0.7	0.8	3.8	-2.0	0.9	-0.3	-0.0	-0.3	-0.1	0.9
Basal cell carcinoma (self-reported)	0.7	0.8	2.6	1.3	-0.4	-0.8	-0.1	-0.5	-0.5	1.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.1	0.4	-0.2	-1.7	0.4	0.5	0.2	1.8
Depression (Nagel 2018)	0.6	1.0	3.5	1.9	-0.4	-0.4	1.0	1.1	0.7	0.6
Irritable Bowel Disease (IBD)	0.6	1.5	5.2	-0.1	1.3	2.3	1.1	1.0	1.2	-0.1
Blood Eosinophil Count	0.6	4.6	9.2	1.4	1.9	3.0	2.2	2.0	2.1	-2.0
BMI	0.6	3.4	8.5	2.9	-1.6	-1.9	-2.0	-1.7	-1.4	0.3
Hypothyroidism (self reported)	0.6	1.4	3.3	-1.8	-0.8	0.4	-1.1	-1.0	-1.0	-1.5
Chronotype (morning person)	0.6	1.5	5.3	0.8	-0.9	-1.2	-0.6	-0.9	-1.0	2.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	4.0	-2.0	0.3	0.3	-0.7	-0.5	-0.1	0.9
Systolic blood pressure, automated reading	0.6	1.9	7.5	2.7	1.3	0.1	0.9	0.9	0.8	1.4
Vitamin and mineral supplements	0.6	0.8	3.1	1.4	-0.7	-1.8	0.1	0.0	-0.1	0.4
Impedance of leg (right)	0.6	2.8	5.6	-1.6	0.6	-1.4	2.4	2.1	1.3	1.8
Had menopause	0.6	0.8	2.1	-1.5	0.7	0.1	-0.7	-0.4	0.2	1.4
Had other major operations	0.6	0.7	1.5	0.9	1.2	1.0	0.8	0.7	0.7	-0.3
Hip circumference	0.6	2.5	4.1	1.4	-2.0	-1.7	-2.0	-1.7	-1.2	0.1
Pulse rate	0.6	1.0	2.3	1.0	-0.5	-1.2	1.1	0.7	-0.2	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.1	-0.3	-0.4	0.4	-0.8	-0.8	-0.5	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.5	1.1	0.4	-0.4	-0.5	-0.4	-0.2	1.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.1	-0.5	-0.2	-1.2	0.7	0.8	0.5	1.4
Medication: Ibuprofen	0.6	0.7	3.6	0.1	-0.1	0.8	-0.6	-0.6	-0.3	-1.9
Leg fat mass (right)	0.6	2.5	6.1	1.0	-1.9	-2.5	-1.7	-1.4	-1.1	0.7
Number of full sisters	0.6	0.7	2.3	0.0	1.5	0.6	0.8	0.8	0.6	0.6
Leg pain on walking	0.6	0.7	1.7	-1.0	-1.1	-1.3	-0.9	-0.5	-0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.5	-0.7	-0.8	-1.9	-1.5	-1.2	-0.5	0.4
Whole body fat-free mass	0.6	3.2	6.8	-0.3	-1.6	-0.0	-2.6	-2.5	-1.8	-1.8
Leg fat-free mass (right)	0.6	3.4	7.7	-0.1	-1.9	-0.4	-2.8	-2.5	-1.9	-1.5
Average weekly red wine intake	0.6	0.9	1.7	0.4	-0.9	-0.9	-0.9	-1.1	-1.3	-1.0
Commuting to job workplace: Walk	0.6	0.6	3.0	1.7	0.6	-0.3	-0.1	-0.0	0.3	0.9
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.3	-0.7	0.9	1.3	0.1	0.3	0.9	-1.5
Miserableness	0.6	1.0	2.1	0.1	1.0	0.6	1.5	1.3	1.1	0.8
Medication: Bendroflumethiazide	0.6	0.9	2.9	-0.4	0.8	1.7	0.5	0.4	0.2	-1.3
Medication: Atorvastatin	0.6	0.8	3.3	-1.8	1.2	0.2	0.4	0.3	0.3	-0.2
Fractured/broken bones in last 5 years	0.6	0.7	1.4	0.3	0.9	0.9	0.8	0.8	0.8	-1.2
Alcohol drinker status: Previous	0.6	0.7	1.0	-0.7	-0.4	0.7	-0.9	-1.0	-0.9	-1.0
Depressed Affect (Nagel 2018)	0.5	1.2	2.2	1.1	0.5	0.2	1.4	1.5	1.4	0.5
Alzheimer’s Disease (including proxy)	0.5	0.7	1.6	-1.2	1.3	0.6	0.0	-0.2	-0.0	-1.1
Major Depression (MDD)	0.5	0.7	2.5	1.0	0.1	-0.9	-0.4	-0.1	0.3	1.6
Mean Putamen Volume	0.5	0.6	1.2	0.0	-1.1	-0.2	-0.9	-0.9	-0.9	0.6
LDL Cholesterol	0.5	0.8	2.4	0.9	-0.8	-0.2	-1.5	-1.2	-0.4	0.0
Blood Red Count	0.5	4.5	29.3	5.4	0.6	0.8	-0.1	-0.4	-0.4	1.0
Heel T-Score	0.5	3.9	7.7	-2.2	2.5	2.8	1.3	1.3	2.1	-0.6
Medication: Co-codamol	0.5	0.6	2.0	-0.3	-1.0	-1.4	0.2	0.2	-0.5	0.9
Medication: Metformin	0.5	0.7	1.9	0.4	0.8	-1.0	-0.7	-0.7	-0.1	1.4
Trunk predicted mass	0.5	2.7	5.4	-0.5	-1.3	0.2	-2.3	-2.3	-1.7	-1.9
Tense / ‘highly strung’	0.5	0.7	1.8	-0.8	0.0	-0.5	1.4	1.2	0.7	0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.2	1.1	-0.4	-1.0	-0.4	-0.6	-1.1	0.3
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.3	-1.1	-0.5	-0.8	-0.5	-0.7	-0.9	0.2
Wheeze or whistling in the chest in last year	0.5	0.9	2.1	-0.7	0.5	0.6	1.4	1.4	1.0	-0.3
Age at first live birth	0.5	0.8	3.0	-1.5	-0.4	-0.3	0.4	0.0	-0.6	-1.7
Neck or shoulder pain in last month	0.5	0.8	1.6	-0.0	-0.2	-0.4	0.8	1.2	1.2	-1.3
Medication: Blood pressure	0.5	0.9	3.3	-0.4	0.4	-1.5	-0.2	-0.3	-0.2	1.8
Medication: Allopurinol	0.5	0.7	3.5	-1.9	0.2	-0.2	0.6	0.6	0.1	0.7
Family relationship satisfaction	0.5	0.6	1.3	0.1	-0.2	-0.3	1.1	1.1	0.7	1.0
Medication: Aspirin	0.5	0.7	2.5	-0.4	0.7	-0.6	0.5	0.7	0.7	1.6
Mood swings	0.5	0.9	2.0	0.9	0.1	-0.7	1.3	1.4	1.2	0.2
Breast cancer (self-reported)	0.5	0.6	1.6	-0.1	0.9	0.1	0.8	0.9	1.3	-0.5
Medication: Aspirin	0.5	0.7	2.3	-0.7	0.8	-0.6	0.5	0.6	0.6	1.5
Medication: Gliclazide	0.5	0.5	1.3	-0.5	0.9	0.0	0.6	0.7	0.7	1.1
Whole body water mass	0.5	3.1	6.7	-0.1	-1.5	0.0	-2.6	-2.5	-1.8	-1.8
Financial situation satisfaction	0.5	0.6	1.3	1.1	-0.6	0.0	-0.6	-0.8	-1.1	-0.6
Commuting to job workplace: Public transport	0.5	0.5	1.3	-0.5	-0.5	-0.5	-1.0	-1.1	-0.9	-0.0
Basal metabolic rate	0.5	2.7	6.2	-0.2	-1.6	-0.4	-2.5	-2.3	-1.7	-1.5
Diastolic blood pressure, automated reading	0.5	1.5	9.5	3.1	0.3	0.0	-0.1	-0.2	-0.6	0.5
Myopia	0.5	0.7	2.0	0.2	0.9	0.7	0.6	0.8	0.8	-1.4
Pain experienced in last month	0.5	0.8	3.1	-1.8	0.0	-0.2	-0.7	-0.6	-0.7	1.0
Leg fat mass (left)	0.5	1.9	5.3	0.8	-1.7	-2.3	-1.4	-1.1	-0.9	0.8
Ovarian Cancer	0.4	0.5	2.1	0.4	0.1	1.0	0.0	0.1	-0.2	-1.4
Blood White Count	0.4	2.7	9.2	3.0	0.4	1.9	1.3	1.0	0.7	-1.7
Height	0.4	8.1	24.2	-4.9	-1.9	-2.2	-2.9	-3.0	-2.5	-0.9
Smoking Status	0.4	1.1	5.4	-2.3	0.4	1.1	0.2	0.2	0.4	-0.7
Cardiovascular Disease	0.4	1.3	2.1	1.0	-1.0	-1.4	-0.8	-0.9	-1.3	1.3
Lung FEV1/FVC ratio	0.4	2.2	14.4	3.8	-0.5	-0.1	-0.2	0.3	0.6	0.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.5	-0.1	-1.0	-1.6	0.1	0.2	-0.2	0.8
Supplements: Zinc	0.4	0.4	1.2	-0.1	-0.0	0.8	-0.9	-1.1	-0.5	0.3
Diabetes (father)	0.4	0.6	1.9	-0.2	-0.4	-0.0	-0.9	-0.7	-0.7	-1.4
Fed-up feelings	0.4	0.7	2.3	0.2	-0.8	-1.5	-0.0	0.0	-0.3	1.3
Stomach or abdominal pain in last month	0.4	0.5	3.1	1.8	0.2	0.5	0.2	-0.0	-0.5	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.8	-0.8	-0.1	-1.0	0.2	0.4	0.4	1.7
Fluid intelligence score	0.4	0.9	2.0	-0.8	0.4	0.3	0.9	1.1	1.1	-1.4
Weight	0.4	2.0	4.3	0.3	-1.7	-1.4	-2.1	-1.8	-1.3	-0.4
Arm fat percentage (right)	0.4	1.5	3.8	0.8	-1.6	-1.9	-1.3	-0.9	-0.7	0.5
Trunk fat-free mass	0.4	2.6	5.1	-0.4	-1.2	0.3	-2.2	-2.3	-1.6	-1.9
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.3	-0.4	-0.8	-1.1	-0.8	-0.7	-1.1	-1.1
Medication: Lansoprazole	0.4	0.4	1.7	0.6	-0.4	-0.7	0.2	0.1	-0.3	1.3
Arm fat mass (right)	0.4	1.5	2.6	0.9	-1.4	-1.6	-1.6	-1.2	-0.8	0.4
Medication: Amlodipine	0.4	0.5	1.2	0.5	-0.6	-1.0	-0.5	-0.5	-0.7	1.1
Medication: Ventolin 100micrograms inhaler	0.4	0.6	2.0	-1.4	-0.5	0.1	0.8	0.6	0.2	-0.7
Leg fat percentage (right)	0.4	1.5	6.3	1.1	-1.2	-2.5	-0.6	-0.4	-0.3	1.0
Arm fat-free mass (right)	0.4	1.9	4.2	0.1	-1.1	0.1	-2.0	-1.9	-1.2	-1.7
Exposure to tobacco smoke outside home	0.4	0.5	2.8	1.7	-0.3	-0.3	0.7	0.5	-0.0	0.1
Qualifications: College or University degree	0.4	1.3	6.6	-0.9	-0.4	0.8	-0.6	-0.4	-0.2	-2.6
Medication for pain relief, constipation, heartburn	0.4	0.7	1.2	1.1	-1.1	0.1	-0.7	-0.7	-0.9	-0.9
Angina (self-reported)	0.4	0.6	1.1	-1.0	-1.0	-0.5	-0.6	-0.4	-0.6	0.9
Whole body fat mass	0.4	1.7	4.0	0.8	-1.6	-2.0	-1.5	-1.2	-0.9	0.4
Pulse rate, automated reading	0.4	1.4	5.2	0.2	-0.4	-0.8	1.6	1.0	0.3	2.3
Chest pain or discomfort	0.4	0.6	1.9	0.6	-0.1	1.0	0.5	0.6	0.2	-1.4
Arm fat percentage (left)	0.4	1.7	4.5	0.9	-1.6	-2.1	-1.5	-1.0	-0.8	0.4
Back pain experienced in last month	0.4	0.5	2.9	-0.2	-0.3	0.7	-0.0	-0.2	-0.3	-1.7
Arm fat mass (left)	0.4	1.5	2.9	1.0	-1.4	-1.6	-1.7	-1.3	-0.8	0.2
Average weekly champagne plus white wine intake	0.4	0.5	2.2	0.7	0.2	0.7	0.2	0.5	0.5	-1.5
Mother’s age at death	0.4	0.5	1.5	1.0	0.8	1.2	0.0	0.0	-0.0	-0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.0	-1.0	0.9	0.2	0.6	0.8	1.0	0.3
Ever smoked	0.4	0.7	2.4	0.1	0.8	1.6	0.6	0.5	0.9	-0.8
Impedance of whole body	0.4	2.2	3.4	-1.6	0.1	-1.6	1.9	1.7	0.9	1.7
Arm predicted mass (left)	0.4	2.0	4.5	-0.0	-1.3	0.2	-2.1	-2.0	-1.4	-1.4
Alzheimer’s Disease (in father)	0.3	0.3	1.5	-0.1	1.2	0.3	0.5	0.3	0.4	-0.3
Neuroticism (2016)	0.3	0.4	1.7	-0.5	0.3	-1.0	-0.2	-0.0	0.0	1.3
Ulcerative Colitis	0.3	0.4	1.0	-0.0	0.6	1.0	1.0	0.7	0.3	-0.4
Systolic Blood Pressure	0.3	1.7	10.1	3.2	-0.1	-0.8	0.6	0.8	0.4	0.5
Hand grip strength (left)	0.3	0.7	2.7	-0.3	0.3	-0.1	-0.1	-0.8	-1.0	-1.7
Average weekly spirits intake	0.3	0.3	0.7	-0.8	0.6	0.8	0.6	0.2	-0.1	-0.4
Angina	0.3	0.4	1.0	-1.0	-0.7	-0.2	-0.4	-0.2	-0.5	0.9
Medication for hormone replacement therapy	0.3	0.4	1.6	-1.3	0.7	0.5	0.2	0.2	0.1	-0.2
Taking other prescription medications	0.3	0.4	2.5	-0.1	-0.4	-1.6	0.1	0.2	-0.6	0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.3	1.1	-0.6	0.0	-0.3	-0.3	-0.8	-0.7
Sitting height	0.3	2.1	3.6	-1.5	-0.7	1.0	-1.7	-1.8	-1.2	-1.9
Body mass index (BMI)	0.3	1.1	2.9	1.7	-1.0	-1.1	-1.3	-0.9	-0.5	-0.1
Trunk fat mass	0.3	1.5	3.5	0.6	-1.7	-1.9	-1.4	-1.1	-0.8	0.0
Heart attack	0.3	0.4	1.1	-0.8	1.1	0.3	0.1	0.5	0.8	0.3
Neuroticism score	0.3	0.7	1.4	-0.4	0.5	-0.1	1.0	1.2	1.1	0.9
Impedance of arm (right)	0.3	1.5	4.3	-2.1	-0.7	-1.7	0.8	0.7	-0.1	1.3
Alcohol intake versus 10 years previously	0.3	0.4	1.3	0.3	1.1	0.9	0.3	0.4	0.7	-0.0
Falls in the last year	0.3	0.4	1.4	-0.3	-0.7	-0.6	-0.0	-0.3	-0.7	-1.2
Asthma	0.3	0.6	2.3	-1.5	-0.4	0.1	0.1	0.3	0.2	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.9	1.7	-0.6	0.6	-0.7	-0.6	-0.1	-1.2
Impedance of arm (left)	0.3	1.4	3.1	-1.8	-0.3	-1.7	1.0	0.9	0.1	1.3
Standing height	0.3	2.6	8.1	-2.9	-1.3	-0.7	-1.6	-1.7	-1.4	-0.6
Birth weight	0.3	0.6	1.5	1.2	-1.1	-0.9	-0.2	-0.1	-0.6	0.0
High blood pressure (siblings)	0.3	0.5	1.4	1.2	0.7	0.4	-0.9	-0.6	-0.3	0.2
Body fat percentage	0.3	1.2	4.6	0.9	-1.3	-2.1	-0.7	-0.4	-0.3	0.7
Comparative body size at age 10	0.3	0.8	3.4	0.5	-0.5	-1.9	-0.7	-0.6	-0.3	1.0
Worry too long after embarrassment	0.3	0.5	1.6	0.6	1.2	0.2	0.3	0.6	1.0	0.5
Number of children fathered	0.3	0.3	1.6	1.3	0.3	0.2	-0.1	-0.1	-0.2	0.4
Arm predicted mass (right)	0.3	1.6	3.5	0.2	-0.8	0.3	-1.9	-1.7	-1.0	-1.8
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	-0.7	-0.7	-0.2	-0.3	-0.4	-0.6	-0.6
Friendships satisfaction	0.3	0.3	1.4	-0.6	-0.4	-0.1	0.1	-0.1	-0.4	1.2
Asthma (self-reported)	0.3	0.5	1.7	-1.3	-0.6	0.0	0.1	0.3	0.1	-1.2
Osteoarthritis (self-reported)	0.3	0.4	1.2	1.0	1.1	-0.8	0.1	0.1	0.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	3.1	1.8	0.8	0.0	-0.2	-0.1	0.4	-0.2
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.9	1.4	-0.4	-0.2	0.2	-0.2	-0.4	-0.6
Medication: Paracetamol	0.3	0.4	1.3	-1.1	-0.3	-0.5	-0.1	-0.4	-0.8	-0.8
Leg fat percentage (left)	0.3	1.1	5.1	0.8	-1.0	-2.3	-0.2	0.1	0.1	1.1
Arm fat-free mass (left)	0.3	1.4	3.0	-0.1	-0.8	0.4	-1.7	-1.7	-1.0	-1.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-0.8	1.1	0.4	-0.0	0.4	0.7	0.2
Ulcerative Colitis (UC)	0.2	0.3	1.7	-0.5	0.3	1.3	-0.1	-0.2	0.1	0.2
Lung FVC	0.2	1.0	4.2	-0.2	0.4	2.1	-0.6	-0.7	-0.2	-1.3
Severe depression (siblings)	0.2	0.2	0.6	0.8	0.2	-0.3	0.3	0.4	0.5	-0.3
Trunk fat percentage	0.2	0.9	3.6	0.8	-1.2	-1.9	-0.7	-0.3	-0.2	0.4
Hand grip strength (right)	0.2	0.5	2.9	0.2	-0.2	0.2	-0.2	-0.5	-0.7	-1.7
Current tobacco smoking	0.2	0.3	1.0	-0.8	-0.2	-0.0	-0.7	-0.4	-0.0	1.0
Qualifications: CSEs or equivalent	0.2	0.2	0.6	0.4	0.7	-0.2	-0.2	-0.1	0.4	0.8
Medication: Atenolol	0.2	0.2	0.5	0.4	0.5	-0.7	-0.4	-0.1	0.5	0.4
Number of incorrect matches in round	0.2	0.4	1.2	-0.2	-0.9	-0.3	0.0	-0.4	-1.1	0.5
Financial difficulties in last 2 years	0.2	0.2	0.5	0.2	0.3	0.3	0.6	0.7	0.3	-0.7
Allergy	0.2	0.5	1.7	0.8	0.8	1.3	-0.3	-0.5	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.1	1.0	-0.9	0.3	-1.0	-1.0	-0.9	-1.0
Birth weight of first child	0.2	0.3	0.6	-0.8	-0.0	-0.7	0.7	0.6	0.3	0.5
Peak expiratory flow (PEF)	0.2	0.6	1.7	1.1	0.5	1.3	0.1	0.4	0.7	-0.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.5	0.5	0.5	0.2	0.3	0.4	0.7
Glaucoma (self-reported)	0.2	0.2	0.5	-0.2	-0.0	-0.0	-0.7	-0.6	-0.6	-0.7
Shortness of breath walking on level ground	0.2	0.3	0.5	0.1	-0.6	-0.7	-0.6	-0.4	-0.5	0.3
Age at last live birth	0.2	0.4	1.7	0.3	-0.4	0.1	-0.1	-0.2	-0.7	-1.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.1	1.0	0.1	0.2	-0.7	-0.6	0.0	-0.2
Medication for cholesterol	0.2	0.3	0.5	-0.2	-0.7	-0.7	-0.7	-0.5	-0.7	0.3
Smoking status: Current	0.2	0.4	0.9	-0.8	-0.4	-0.3	-0.9	-0.7	-0.4	0.6
Number of self-reported non-cancer illnesses	0.2	0.4	1.1	0.4	0.8	-0.2	1.1	0.8	0.1	0.1
Cholesterol lowering medication	0.2	0.4	0.9	0.1	0.9	0.0	0.8	0.5	0.4	0.7
HDL Cholesterol	0.1	0.2	0.4	0.5	-0.1	0.6	-0.0	-0.3	-0.5	-0.0
Blood Platelet Count	0.1	1.7	5.0	2.2	-0.9	-1.9	-0.2	-0.3	-1.0	1.3
Tanning	0.1	0.7	1.9	-1.3	-0.4	-1.0	0.1	-0.1	-0.1	1.4
Number of treatments/medications taken	0.1	0.2	0.9	0.9	0.5	-0.0	0.5	0.3	-0.1	0.3
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.0	-0.5	0.4	-0.4	0.0	0.2	-0.2
Average weekly fortified wine intake	0.1	0.2	0.5	-0.7	0.1	-0.7	-0.2	-0.2	-0.2	0.3
Age when periods started (menarche)	0.1	0.3	1.5	-1.2	0.1	0.7	-0.2	-0.3	0.2	-0.2
High blood pressure	0.1	0.2	0.9	0.6	0.5	-0.2	0.3	0.2	0.2	0.9
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.7	0.0	-0.4	0.4	0.4	0.4	0.5
Waist circumference	0.1	0.3	1.3	1.1	-0.4	-0.7	-0.1	0.0	0.2	0.2
Forced vital capacity (FVC)	0.1	0.4	0.6	-0.3	-0.6	0.8	-0.5	-0.7	-0.7	-0.7
Illnesses of siblings	0.1	0.2	0.8	0.2	-0.9	-0.2	0.5	0.3	-0.2	-0.2
Father’s age at death	0.1	0.1	0.6	0.4	0.3	0.8	-0.1	0.1	0.3	-0.2
Noisy workplace	0.1	0.2	0.4	-0.2	-0.4	-0.4	0.6	0.2	-0.5	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.5	1.6	0.5	-0.2	1.3	0.0	-0.0	0.3	-1.2
Emphysema/chronic bronchitis	0.1	0.1	0.4	0.6	-0.3	-0.3	0.1	0.2	0.2	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.5	0.3	0.0	0.4	-0.7	-0.4	-0.1	-0.2
Knee pain experienced in last month	0.1	0.1	0.3	0.1	0.2	-0.1	0.5	0.6	0.5	-0.2
Hypertension (Self-reported)	0.1	0.2	0.8	0.7	0.5	-0.1	0.1	0.1	0.2	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	0.7	-0.0	-0.0	-0.1	-0.1	-0.1	-0.4
Hearing aid user	0.1	0.1	0.3	-0.5	0.1	-0.2	0.1	0.1	0.3	0.6
Medication: Lisinopril	0.1	0.1	0.4	0.0	0.4	-0.5	0.2	-0.3	-0.6	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.5	-0.4	-0.8	0.1	-0.5	-0.4	-0.3	-1.2
Allergy or Eczema	0.0	0.1	0.4	0.5	-0.1	-0.7	0.2	0.0	0.1	0.3
Hair Pigment	0.0	0.8	2.4	-0.2	-1.6	-0.4	-0.9	-0.7	-1.1	-0.6
Medication: Paracetamol	0.0	0.1	0.3	-0.3	0.1	-0.1	0.1	-0.2	-0.4	-0.5
Comparative height size at age 10	0.0	0.1	0.2	-0.4	-0.4	-0.4	-0.2	-0.2	0.1	0.1

Hub : Genes

AUTS2

Models

Trait associations