TWAS hub - PREP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0600	0.0240	0.00320	0.041	0.015	0.029	0.018	0.034	9.3e-06	5.2e-03	1.5e-04	2.7e-03	5.1e-05
2	GTEx	Brain Cerebellar Hemisphere	0.4410	0.1060	0.00083	0.014	NA	0.099	NA	0.029	1.4e-01	NA	1.7e-03	NA	6.1e-02
3	GTEx	Muscle Skeletal	0.1526	0.0468	0.00140	0.013	NA	0.027	NA	0.013	1.6e-02	NA	1.0e-03	NA	1.6e-02
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1610	0.0630	0.00480	0.030	NA	0.059	NA	0.054	8.4e-03	NA	3.7e-04	NA	6.6e-04
5	GTEx	Skin Sun Exposed Lower leg	0.1460	0.0490	0.00034	0.057	NA	0.038	NA	0.050	1.8e-05	NA	3.7e-04	NA	5.6e-05
6	YFS	Blood	0.0412	0.0149	0.00072	0.020	0.012	0.017	0.017	0.017	3.5e-07	5.2e-05	2.3e-06	2.2e-06	2.7e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Pulse rate	5.4	9.2	21.6	-3.7	1.1	-2.2	-3.1	-2.0	-4.7
Hair/balding pattern: Pattern 4	4.9	11.9	46.4	-2.2	6.8	1.6	-2.9	-2.7	-1.4
Average weekly champagne plus white wine intake	4.0	5.5	12.9	3.6	-0.8	0.8	3.1	1.5	2.6
High blood pressure (mother)	3.8	5.4	9.2	-2.4	2.7	-0.2	-2.6	-1.9	-3.0
Number of incorrect matches in round	3.7	6.2	15.0	2.6	-1.6	-0.6	3.0	1.8	3.9
Exposure to tobacco smoke outside home	3.5	4.6	11.8	-2.4	0.2	-0.7	-3.4	-2.1	-2.3
Pulse rate, automated reading	3.4	10.8	33.3	-4.8	0.5	-1.1	-2.7	-0.3	-5.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.6	8.4	-0.3	-1.6	2.4	-2.9	-2.3	-0.3
Number of treatments/medications taken	2.8	5.0	10.4	-1.9	3.2	-1.9	1.6	2.3	-2.2
Ever highly irritable/argumentative for 2 days	2.7	3.2	5.6	0.6	2.2	2.4	-2.1	-1.6	-1.1
Stomach or abdominal pain in last month	2.5	3.1	5.9	-2.2	2.4	-2.2	-1.0	-0.4	-1.4
Medication: Atorvastatin	2.5	3.1	9.5	0.7	0.4	-1.2	3.1	2.4	1.0
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	7.0	-2.6	1.4	-0.2	-1.2	-0.9	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.9	14.0	2.4	-0.4	-1.5	2.4	1.3	3.7
Ever had prostate specific antigen (PSA) test	2.0	2.3	3.3	1.5	-1.7	1.0	1.3	1.7	1.8
Medication: Ramipril	1.9	2.4	5.2	-1.0	0.7	2.1	1.5	1.0	-2.3
Long-standing illness, disability or infirmity	1.9	2.8	8.7	-3.0	1.2	-0.7	-1.7	-1.2	-1.4
Average weekly beer plus cider intake	1.9	2.7	7.1	-2.5	-0.0	-2.7	0.0	1.0	-1.4
Relative age of first facial hair	1.8	3.6	11.8	-0.7	-3.4	0.5	-2.7	0.5	-1.3
Qualifications: CSEs or equivalent	1.8	2.4	6.4	-1.1	0.8	-1.1	-2.2	-2.5	-0.8
Average weekly red wine intake	1.8	2.6	7.2	2.7	-0.1	1.4	1.3	-0.4	2.1
Average weekly spirits intake	1.7	2.1	4.7	1.2	1.6	-2.2	-0.1	-0.7	1.8
Illnesses of mother	1.7	2.1	3.9	1.1	-1.7	-0.1	2.0	1.3	1.7
Pulse wave peak to peak time	1.7	2.0	7.5	0.3	-2.7	-0.5	0.8	1.4	1.2
Neck or shoulder pain in last month	1.7	2.4	8.0	-1.5	0.2	-2.8	-1.4	-1.4	0.2
Pain experienced in last month	1.7	2.8	8.3	1.9	-1.2	2.9	1.3	1.4	0.1
Rheumatoid Arthritis	1.6	2.2	6.2	-0.9	1.1	0.0	-2.5	-2.2	-0.1
Lung cancer (father)	1.6	1.9	5.9	-2.4	1.3	-1.3	-1.2	-0.2	-0.7
Pulse wave Arterial Stiffness index	1.6	1.8	7.3	-0.4	2.7	0.4	-0.6	-1.2	-1.3
Glaucoma (self-reported)	1.6	1.9	6.6	-1.0	1.6	-2.6	-1.0	0.3	-0.8
Medication: Ventolin 100micrograms inhaler	1.6	2.0	6.2	-1.7	1.5	-0.4	-0.8	0.4	-2.5
Asthma (self-reported)	1.6	3.2	7.0	-2.6	-0.0	-0.6	-2.2	0.5	-2.5
Illnesses of father: High blood pressure	1.6	2.0	4.0	-1.6	2.0	-0.4	-1.8	-1.1	-1.1
Number of children fathered	1.5	1.7	6.4	0.4	-2.5	1.3	0.1	0.6	1.2
Eye problems/disorders: None of the above	1.5	1.7	3.6	1.9	-1.0	0.6	1.6	0.4	1.6
Number of full sisters	1.5	1.8	6.0	1.1	0.5	2.5	-0.9	-1.3	-0.9
Loneliness, isolation	1.5	2.1	9.1	-0.1	3.0	-0.8	-0.2	-0.8	-1.5
Pain type(s) experienced in last month: Hip pain	1.5	1.9	5.0	-2.2	0.4	-1.3	-1.6	-1.0	-0.9
Heart attack/myocardial infarction (self-reported)	1.5	2.0	4.6	1.5	-1.3	0.3	1.4	1.1	2.2
Schizophrenia (2018)	1.4	3.0	8.2	0.0	-1.8	1.2	1.2	2.9	-1.9
Mean Putamen Volume	1.4	1.6	5.2	1.1	-0.8	0.5	2.3	1.5	0.2
Medication for hormone replacement therapy	1.4	1.5	4.9	-0.2	0.1	2.2	1.1	1.7	0.3
Asthma	1.4	2.7	5.9	-2.4	0.0	-0.7	-1.9	0.8	-2.4
Osteoarthritis (self-reported)	1.4	1.8	6.1	-1.7	-1.1	-2.5	-0.2	-0.7	-0.6
Tinnitus: Yes, now most or all of the time	1.4	1.6	4.9	1.8	-0.1	-0.0	1.1	0.5	2.2
Eye problems/disorders: Glaucoma	1.4	1.7	3.4	-1.5	1.8	-1.4	-0.7	0.8	-1.0
Major Depression (MDD)	1.3	1.6	7.5	1.0	0.3	-0.7	-0.4	0.6	2.7
Body Mass Index (BMI) (2010)	1.3	1.8	5.1	0.4	1.9	2.3	0.3	0.7	-1.3
HbA1C	1.3	1.4	4.9	-2.2	0.3	-1.1	-0.8	-0.1	-1.3
Age when periods started (menarche)	1.3	3.1	10.1	-0.3	-0.1	-0.2	-3.2	-1.9	-2.1
Diabetes (self-reported)	1.3	2.0	4.4	1.1	1.1	-0.4	2.1	1.3	1.8
Medication: Lisinopril	1.3	1.6	4.2	-0.3	0.3	1.0	2.1	1.8	1.1
Alzheimer’s Disease (in father)	1.2	1.3	3.1	0.6	-0.4	-1.2	1.3	0.9	1.8
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	4.2	-0.7	0.2	2.0	-0.0	0.1	-2.0
Multivitamins +/- minerals	1.2	1.5	3.9	0.2	1.8	-2.0	0.7	1.0	-0.4
Heart attack	1.2	1.5	4.1	1.3	-0.8	0.1	1.3	1.0	2.0
Loud music exposure frequency	1.2	1.3	4.6	0.9	2.1	-0.4	0.2	-1.1	1.0
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	5.4	0.1	-1.4	0.9	-2.3	-1.9	-0.4
Heart disease (mother)	1.2	1.4	3.5	1.9	0.3	-1.7	1.0	-0.0	1.0
Qualifications: nursing, teaching	1.2	1.9	5.3	-0.8	0.4	2.3	0.3	1.1	-1.9
Basal cell carcinoma (self-reported)	1.2	1.4	5.4	1.3	0.2	-1.1	0.2	-0.4	2.3
Bipolar Disorder (2018)	1.1	1.7	5.3	0.1	2.3	1.1	-1.6	-0.9	-0.1
Verbal and Numeric Reasoning (VNR)	1.1	2.5	7.8	-0.6	1.5	1.4	-2.8	-1.6	-0.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.8	0.2	1.6	2.0	0.8	0.8	-1.3
Vitamin and mineral supplements	1.1	1.5	5.5	0.0	-2.4	1.3	-0.0	0.5	1.1
Average weekly fortified wine intake	1.1	1.3	3.3	-1.8	0.8	-1.6	-0.5	0.1	-1.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.5	-0.1	1.7	-1.9	1.1	0.2	0.2
Headache pain in last month	1.1	1.9	3.6	-1.9	1.8	-1.3	-1.0	-0.6	-1.1
Overall health rating	1.1	2.4	4.8	-2.2	1.2	-0.0	-1.7	-0.6	-2.2
Chest pain or discomfort	1.1	1.6	2.7	1.3	1.6	-1.1	1.3	1.3	0.5
Illnesses of father: None of the above (group 1)	1.1	1.4	3.5	-0.9	-1.4	-0.3	-1.9	-1.3	-0.6
Risk taking	1.1	1.6	5.1	1.8	-0.1	2.2	0.8	0.6	0.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.2	-1.4	-0.7	1.5	-0.6	-1.1	-1.5
Depression (Nagel 2018)	1.0	1.4	3.3	-0.2	1.5	1.2	-0.5	-1.1	-1.8
Lung FVC	1.0	5.1	13.7	2.9	-0.5	0.2	2.6	1.1	3.7
Diabetes (mother)	1.0	1.3	4.9	-0.6	2.2	0.6	-1.0	-1.1	0.2
Hair/balding pattern: Pattern 2	1.0	1.3	3.7	0.5	-1.0	-0.3	1.5	1.9	-0.4
Happiness	1.0	1.2	2.0	1.1	-0.6	1.0	1.4	1.2	1.0
Medication: Cholesterol lowering	1.0	1.6	4.8	0.3	0.4	-1.4	2.2	1.4	0.9
Depression (self-reported)	1.0	1.1	2.7	0.9	0.0	-1.5	1.6	0.9	0.6
Medication: Lansoprazole	1.0	1.1	2.2	-0.9	1.3	-1.5	0.5	1.0	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.0	-0.4	2.0	-0.8	1.7	0.9	-0.3
Medication: Amlodipine	1.0	1.4	4.4	-0.2	0.6	-1.6	1.0	2.1	-0.4
Comparative body size at age 10	1.0	2.9	7.2	-0.1	-2.5	0.6	2.7	1.8	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	7.1	0.6	2.7	-0.2	0.6	0.0	0.5
Medication: Blood pressure	1.0	1.7	3.6	-0.7	1.4	-0.8	1.9	1.9	-0.2
Medication: Omeprazole	1.0	1.2	2.8	-0.2	0.7	-1.3	1.7	1.4	-0.6
Suffer from ‘nerves’	1.0	1.6	5.4	0.0	1.6	-0.6	-0.7	-2.3	0.8
Knee pain experienced in last month	1.0	1.5	5.2	-1.1	2.3	-1.4	-0.5	-0.4	-0.8
Irritable Bowel Disease (IBD)	0.9	2.1	8.6	1.6	-2.9	-0.7	-0.3	-0.7	0.6
Diabetes (father)	0.9	1.1	3.4	0.6	0.2	1.3	0.6	0.7	1.8
Hand grip strength (right)	0.9	2.4	9.1	-1.2	-0.2	0.6	-3.0	-1.8	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.7	-0.9	1.6	0.8	-0.7	-0.8	-1.4
Supplements: Glucosamine	0.9	1.1	4.1	-0.3	0.6	-1.4	-0.2	-0.1	-2.0
Blood clot in the leg (DVT)	0.9	1.2	2.2	-1.1	-0.0	1.5	-0.6	-1.2	-1.3
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	7.6	-1.2	-0.4	-2.8	-1.1	0.3	-0.2
Medication: Seretide 50 evohaler	0.9	1.0	1.9	0.8	-1.0	1.4	1.1	1.1	0.1
Medication: Gliclazide	0.9	1.0	2.9	-0.2	0.4	-0.8	1.5	1.7	0.1
Cholesterol lowering medication	0.9	1.3	3.5	-0.0	1.9	-1.1	1.4	0.3	1.0
Supplements: Calcium	0.9	1.0	2.2	1.0	0.3	0.8	1.0	1.5	-0.9
Schizophrenia vs Biploar Disorder	0.8	1.1	3.5	0.0	-1.9	-1.2	0.8	0.9	-0.4
Worry (Nagel 2018)	0.8	1.6	3.4	-0.6	1.6	-1.8	-0.9	-1.6	-0.0
Ulcerative Colitis (UC)	0.8	1.5	4.3	1.4	-2.1	-0.5	-0.9	-1.3	0.2
Reaction Time	0.8	1.5	4.0	-1.3	0.5	-2.0	-0.0	-0.5	1.6
Ovarian Cancer	0.8	1.1	2.2	1.5	1.0	-1.2	0.6	0.3	1.3
Respiratory disease	0.8	1.8	4.6	-2.1	0.4	-1.2	-1.1	0.9	-1.7
Chronotype (morning person)	0.8	1.8	7.9	1.1	-2.8	0.5	1.1	0.6	0.1
Hand grip strength (left)	0.8	2.2	6.6	-1.4	-0.5	0.4	-2.6	-2.0	0.3
Townsend deprivation index at recruitment	0.8	1.1	3.4	-0.5	1.8	-1.1	0.1	0.9	-0.9
Maternal smoking around birth	0.8	1.2	3.1	0.3	-1.1	1.8	-1.6	-0.2	-0.1
Chronic bronchitis/emphysema (father)	0.8	1.0	5.3	-0.5	0.2	-0.3	-0.2	0.5	-2.3
Had other major operations	0.8	0.9	2.2	0.5	1.0	0.4	-0.1	-1.5	1.4
Time employed in main current job	0.8	0.9	2.2	-0.3	-1.5	-0.3	-1.1	-1.2	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	4.5	0.7	0.5	-1.8	2.1	1.5	2.1
Exposure to tobacco smoke at home	0.8	0.9	3.1	1.0	-0.9	1.8	0.3	-0.5	0.2
Pulse wave reflection index	0.8	1.0	3.7	0.3	1.4	1.9	-0.0	0.4	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	3.3	1.2	-0.3	0.8	0.2	0.5	1.8
Qualifications: College or University degree	0.8	2.6	4.4	1.7	-1.3	2.1	1.4	2.1	0.8
Mean time to correctly identify matches	0.8	1.6	5.6	-1.6	0.4	-2.4	0.0	0.3	1.1
Family relationship satisfaction	0.8	0.9	3.7	-0.9	-0.4	1.9	-0.7	-0.4	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.2	0.5	-1.8	0.5	0.4	0.8	1.0
Smoking status: Previous	0.8	1.2	4.7	-0.9	2.2	-0.6	-0.1	-0.8	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	3.2	-0.3	-1.2	1.8	-0.1	0.4	0.2
Friendships satisfaction	0.8	1.0	4.5	-2.1	0.3	0.6	-0.9	0.2	-0.5
Mineral and other dietary supplements	0.8	1.0	2.2	-0.8	-0.0	0.3	-1.5	-1.3	1.2
Ever taken oral contraceptive pill	0.8	0.8	2.2	1.5	0.2	0.5	1.2	1.0	0.4
Mother’s age at death	0.8	1.1	2.4	-0.1	-1.0	-1.4	-1.6	-0.9	0.3
Commuting to job workplace: Public transport	0.8	0.9	1.9	-0.4	-1.4	0.6	-1.2	-1.1	0.5
Medication: Paracetamol	0.8	1.3	3.2	0.7	0.5	-1.1	1.5	1.8	0.6
Unable to work because of sickness or disability	0.8	1.0	2.2	0.9	1.5	0.3	1.3	1.1	-0.4
Schizophrenia (2014)	0.7	1.5	4.2	0.3	-0.1	1.4	0.5	1.6	-2.0
Smoking Status	0.7	1.8	3.6	-0.9	1.8	1.0	-1.0	-1.0	-1.9
Systolic blood pressure, automated reading	0.7	2.0	6.5	-0.6	2.5	-0.4	0.6	1.3	-1.7
Taking other prescription medications	0.7	1.0	2.7	-1.1	0.4	-0.6	0.7	1.2	-1.7
Medication: Levothyroxine sodium	0.7	1.2	3.6	-1.4	-0.1	-1.9	-1.1	0.1	-0.6
Past tobacco smoking	0.7	1.3	5.3	0.8	-2.3	0.4	-0.1	1.2	0.7
Alcohol usually taken with meals	0.7	1.1	3.1	1.5	-0.8	1.8	0.2	-0.2	0.9
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	7.3	1.7	0.6	-0.7	1.5	1.1	2.7
Length of working week for main job	0.7	0.8	2.4	-0.9	-1.6	-0.7	-0.2	-0.8	-0.4
Forced vital capacity (FVC), Best measure	0.7	2.4	4.5	0.8	0.0	-1.8	2.0	1.4	2.1
Number of full brothers	0.7	0.8	1.9	0.5	-0.9	1.3	0.2	0.6	1.4
Health satisfaction	0.7	0.9	2.3	-1.0	1.5	0.3	-0.7	-0.5	-1.1
Shortness of breath walking on level ground	0.7	0.8	2.3	-0.9	0.5	-0.5	0.8	1.5	-0.6
Illnesses of siblings: Diabetes	0.7	0.9	1.9	1.4	0.6	-0.1	1.4	1.1	-0.2
Diabetes diagnosed by doctor	0.7	1.2	2.2	0.4	1.0	-1.1	1.5	1.0	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.0	0.2	-1.7	0.4	-0.6	-0.3	-1.1
Number of self-reported non-cancer illnesses	0.7	1.3	2.8	-0.6	1.7	-1.5	1.2	0.7	0.2
Hearing aid user	0.7	0.8	3.3	-0.3	1.8	0.1	0.7	0.9	0.1
Diastolic blood pressure, automated reading	0.7	2.3	7.0	-1.1	1.7	-0.9	0.5	1.2	-2.6
Bipolar Disorder or Schizophrenia	0.6	1.4	3.0	0.1	-0.0	1.6	0.1	1.7	-1.6
Depressed Affect (Nagel 2018)	0.6	1.3	4.9	0.0	2.2	-0.1	-0.5	-1.2	-1.0
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.1	-1.0	2.0	-0.4	-2.0	-0.4	-1.3
Neuroticism (Nagel 2018)	0.6	1.5	5.0	-0.3	2.2	-0.8	-0.6	-1.6	-0.3
Ulcerative Colitis	0.6	0.9	2.7	1.6	-0.8	-0.6	-0.5	-0.7	0.8
Ever had hysterectomy (womb removed)	0.6	0.7	2.1	-0.2	1.4	-0.9	1.0	-0.4	0.3
Severe depression (siblings)	0.6	0.7	1.8	1.0	0.9	0.2	-0.6	-0.1	1.3
Fed-up feelings	0.6	1.1	4.6	0.8	2.1	-0.4	-0.3	-1.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.2	0.6	1.4	0.8	1.5	0.6	-0.1
Had menopause	0.6	0.8	3.2	0.2	0.5	1.8	0.7	0.2	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.1	-0.3	-1.0	0.9	-0.0	-0.4	-1.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.9	0.0	0.6	0.0	-1.1	-1.7	-0.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.3	-0.5	0.4	0.1	-1.1	-1.5	0.0
Medication for pain relief, constipation, heartburn	0.6	0.9	2.3	0.2	0.9	1.1	-1.5	-0.9	0.5
Leg pain on walking	0.6	0.8	1.8	-0.1	0.3	0.5	-1.2	-1.1	-1.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	3.2	0.0	-0.4	0.9	-0.2	-0.2	1.8
Illnesses of father: Heart disease	0.6	0.8	2.0	0.4	1.4	0.7	1.0	1.1	-0.0
Back pain experienced in last month	0.6	0.8	2.1	-0.7	-0.3	0.7	-0.4	-1.2	-1.4
Medication: Aspirin	0.6	0.8	1.9	-0.1	0.8	0.0	1.4	1.4	-0.2
High cholesterol (Self-reported)	0.6	1.1	2.6	-0.3	0.6	-1.6	1.6	0.9	0.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.5	-0.4	0.3	-1.2	1.0	1.2	-0.9
Alzheimer’s Disease (including proxy)	0.5	0.8	2.6	0.5	-0.4	-0.2	1.6	1.1	0.6
Coronary Artery Disease (CAD)	0.5	0.6	1.5	-0.3	-0.2	1.2	0.9	0.3	-1.0
LDL Cholesterol	0.5	0.7	2.7	-0.1	0.9	-1.6	-0.4	-0.6	0.6
Waist Hip Ratio (WHR)	0.5	2.3	8.3	-0.6	2.9	-0.6	0.9	1.7	-0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.7	0.3	0.3	-1.6	-0.6	-0.7	0.2
Serious illness, injury or assault to yourself	0.5	0.6	1.5	0.3	-0.7	-1.2	0.7	0.4	-0.9
Allergy	0.5	1.0	2.1	1.3	-0.6	0.1	1.4	-0.0	1.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.1	0.0	-0.9	-1.0	-0.7	-1.1	-0.6
Fluid intelligence score	0.5	1.1	1.9	0.2	1.3	1.1	-1.4	-0.4	1.1
Neuroticism score	0.5	1.0	2.4	0.1	1.4	-0.5	-1.1	-1.6	-0.5
Alcohol intake versus 10 years previously	0.5	0.8	2.5	0.2	-0.2	1.6	-0.2	1.4	0.6
Father’s age at death	0.5	0.7	1.6	0.9	-0.2	-1.3	0.7	0.6	0.7
Worrier / anxious feelings	0.5	0.9	2.7	-0.1	0.9	-1.7	-1.1	-0.3	-0.8
Hair/balding pattern: Pattern 3	0.5	0.7	1.5	1.0	1.0	0.5	0.4	1.2	0.5
Medication: Paracetamol	0.5	0.9	2.2	0.6	0.7	-0.9	0.9	1.5	0.6
Gout (self-reported)	0.5	0.7	2.7	-1.0	0.3	0.1	-0.4	-0.4	-1.6
High blood pressure (siblings)	0.5	0.7	1.4	-1.2	0.9	0.1	-0.7	-0.3	-1.2
Worry too long after embarrassment	0.5	0.8	2.2	-0.8	0.8	0.4	-0.7	-0.7	-1.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.7	0.6	0.5	1.6	0.4	0.2	0.1
Emphysema/chronic bronchitis	0.5	0.6	1.3	-0.5	0.7	1.1	-0.5	0.3	-1.1
Medication: Ibuprofen	0.5	0.6	2.5	-0.5	-0.8	0.5	0.3	-0.2	-1.6
Medication: Allopurinol	0.5	0.7	2.1	-0.7	-0.4	0.1	0.4	1.0	-1.4
Had major operations	0.5	0.5	0.9	-0.8	-0.9	-0.2	-0.7	0.5	-1.0
Medication: Aspirin	0.5	0.7	1.7	-0.2	1.0	-0.1	1.3	1.0	-0.4
Hypertension (Self-reported)	0.5	1.4	3.0	-1.7	1.6	0.3	-0.2	0.8	-1.4
Commuting to job workplace: Walk	0.5	0.5	1.3	0.3	1.1	-0.1	0.9	0.8	0.4
Medication for cholesterol	0.5	0.8	2.9	0.3	-1.7	0.3	-0.7	-1.1	-0.0
Miserableness	0.5	0.9	1.7	0.4	1.3	1.1	0.2	-0.5	-1.3
Irritability	0.5	0.8	3.0	0.8	1.7	-1.0	-0.2	-0.5	-0.3
Myopia	0.5	0.7	1.8	0.0	-1.3	0.1	0.8	1.3	0.1
Bipolar Disorder (2011)	0.4	0.4	1.0	0.6	1.0	0.5	-0.8	0.0	-0.1
Lupus	0.4	0.7	1.3	0.9	-0.9	1.0	-0.2	-0.1	1.1
Neuroticism (2016)	0.4	0.6	3.2	-0.3	1.8	-0.5	-0.3	0.1	0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.1	-0.1	0.8	-0.0	0.0	0.1	-1.5
BMI	0.4	2.4	7.1	0.5	-0.0	0.8	2.5	2.7	0.3
Hypothyroidism (self reported)	0.4	0.9	4.5	0.0	0.4	-2.1	0.2	0.9	0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.9	-0.8	1.4	-0.9	-0.0	-0.5	0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	-0.3	0.7	1.0	-0.5	-0.2	-1.1
Angina	0.4	0.5	1.7	0.3	-0.7	-0.7	1.3	0.1	0.4
High blood pressure	0.4	1.1	1.8	-1.4	1.4	0.2	0.2	1.1	-1.3
Medication: Atenolol	0.4	0.5	1.2	-0.4	0.4	-0.1	0.7	1.1	1.1
Forced vital capacity (FVC)	0.4	1.7	5.9	1.4	0.5	-0.8	0.9	0.7	2.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	0.5	0.5	1.0	0.8	0.6	0.9
Financial difficulties in last 2 years	0.4	0.5	1.2	0.6	1.1	-0.5	0.3	0.4	-1.0
Mouth/teeth dental problems	0.4	0.7	2.3	0.5	-1.5	-0.3	0.3	-0.1	1.1
Pain all over the body in last month	0.4	0.4	1.1	-0.6	-0.1	-1.1	0.8	0.4	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.6	0.5	0.8	-0.9	0.3	-0.8	-1.3
Falls in the last year	0.4	0.6	1.3	0.1	0.5	-0.8	0.6	1.1	1.0
Noisy workplace	0.4	0.5	1.9	-0.2	0.4	-0.4	-0.4	-1.4	-0.7
Birth weight of first child	0.4	0.7	3.3	-0.4	1.8	-0.7	0.4	0.4	-0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.7	0.6	1.6	0.1	0.9	0.2	0.6
Age at first live birth	0.4	0.7	2.9	0.7	-0.4	0.6	-0.6	-0.3	1.7
Angina (self-reported)	0.4	0.5	2.1	0.4	-0.5	-0.5	1.4	0.0	0.2
Medication: Bendroflumethiazide	0.4	0.7	2.7	-0.7	1.7	0.1	-0.9	0.0	0.2
Number of operations (self-reported)	0.4	0.6	1.6	-0.8	0.8	1.3	-0.4	0.4	-0.8
Ever depressed for a whole week	0.4	0.5	1.3	-0.1	0.6	1.1	0.3	0.7	-0.7
Commuting to job workplace: Cycle	0.4	0.5	1.0	1.0	0.3	0.4	0.3	1.0	-0.7
Heart disease (siblings)	0.4	0.5	1.3	1.1	1.1	0.5	0.3	-0.2	-0.1
Alzheimer’s Disease (in mother)	0.3	0.3	0.8	0.1	0.3	0.8	0.5	0.4	-0.9
Crohns Disease (2017)	0.3	0.7	2.4	1.0	-1.5	-0.3	-0.1	-0.6	0.4
Age at First Birth	0.3	0.4	1.8	-0.2	-1.4	0.7	-0.2	-0.1	-0.2
Crohns Disease (2012)	0.3	0.5	1.1	0.9	-0.4	-1.0	0.6	0.3	0.7
Cardiovascular Disease	0.3	1.1	3.7	-0.9	1.9	-0.6	0.5	0.6	-0.9
Neuroticism	0.3	0.8	2.9	0.0	1.7	-0.8	-0.5	-0.9	0.1
Tanning	0.3	3.9	10.4	1.6	-2.6	-0.6	1.9	0.0	3.2
Sensitivity / hurt feelings	0.3	0.4	1.4	-0.8	-0.4	0.1	-0.6	-0.2	1.2
Hearing difficulty/problems: Yes	0.3	0.5	1.0	-0.7	1.0	0.8	-0.1	-0.2	-1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.5	-0.3	1.2	-0.4	-0.0	-0.1	-0.7
Relative age voice broke	0.3	0.4	1.5	0.3	-0.8	-0.2	-1.2	-0.1	0.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.3	-0.4	0.7	-0.4	-1.2	-0.6	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.4	-1.2	-0.6	-0.9	-0.6	-0.4	-1.0
Qualifications: None of the above	0.3	0.6	1.5	-0.6	-0.3	-1.2	0.8	0.8	0.3
Medication: Simvastatin	0.3	0.4	1.0	0.1	1.0	-0.6	0.4	-0.1	0.8
Arm fat percentage (right)	0.3	1.0	1.7	-1.3	1.2	-1.2	0.1	1.2	-0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	3.2	0.1	1.8	-0.1	-0.6	0.1	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	0.7	0.6	-0.6	0.3	-0.8	-0.1
Prospective memory result	0.3	0.4	0.8	-0.7	-0.9	-0.6	0.1	0.7	-0.4
Leg fat percentage (right)	0.3	1.0	2.7	0.4	0.6	0.8	1.4	1.6	0.2
Migraine (self-reported)	0.3	0.3	0.9	1.0	0.0	0.8	0.6	-0.2	0.1
Age at last live birth	0.3	0.4	1.1	-0.6	-0.5	-0.5	-1.1	-0.6	0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.4	-0.3	-0.2	-0.6	0.0	-0.2	-1.2
Supplements: Vitamin C	0.3	0.3	1.0	-0.2	0.6	-0.5	1.0	0.0	-0.7
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	0.8	0.5	-0.2	0.2	-1.0	-0.6
Ever had bowel cancer screening	0.3	0.3	0.9	-0.0	-1.0	-0.9	-0.5	-0.2	0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	-0.3	1.2	-0.7	0.1	0.5	0.6
Osteoporosis (self-reported)	0.3	0.4	1.0	0.7	-0.3	0.6	-0.2	0.8	1.0
Guilty feelings	0.3	0.5	1.1	0.7	0.7	1.0	0.4	-0.7	-0.3
Wears glasses or contact lenses	0.3	0.4	0.9	-0.7	-0.3	-0.8	-0.0	1.0	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	-0.0	0.0	-0.4	1.0	0.2	-1.1
Ever smoked	0.3	0.6	1.6	-0.2	1.1	0.5	0.4	-1.2	-0.6
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.5	1.2	-1.2	-0.2	-0.4	-1.1	0.8
Primary Biliary Cirrhosis	0.2	0.3	0.8	-0.4	0.1	-0.1	-0.9	-0.3	-0.8
Blood Red Count	0.2	1.7	5.0	-0.9	1.0	-0.1	-1.4	1.1	-2.2
Heel T-Score	0.2	1.5	3.8	-0.2	-1.9	0.8	-1.4	-1.6	-0.3
Systolic Blood Pressure	0.2	1.1	2.3	-0.9	1.5	-1.2	0.7	0.8	-0.8
Supplements: Zinc	0.2	0.2	0.8	0.9	-0.1	0.2	0.2	-0.6	-0.0
Medication: Co-codamol	0.2	0.2	0.4	-0.6	-0.2	0.5	0.4	-0.4	-0.3
Medication: Metformin	0.2	0.3	1.2	0.0	0.4	-0.0	0.0	-0.6	1.1
Pack years adult smoking proportion	0.2	0.4	1.0	0.7	-1.0	0.7	-0.3	0.2	-0.2
Impedance of leg (right)	0.2	1.2	3.8	1.5	-0.2	2.0	0.7	0.3	0.5
Trunk fat percentage	0.2	0.7	2.5	-0.8	0.6	-0.7	0.1	1.6	-0.6
Sitting height	0.2	1.2	2.9	1.3	0.5	0.3	1.2	1.7	-0.9
Impedance of leg (left)	0.2	0.9	2.3	1.5	-0.0	1.5	0.4	-0.3	0.7
Trunk fat mass	0.2	0.8	2.6	-0.8	0.6	-0.8	0.0	1.6	-0.6
Waist circumference	0.2	0.6	1.4	-0.7	0.8	-0.8	0.1	1.2	-0.7
Illnesses of siblings	0.2	0.2	0.8	-0.0	-0.7	-0.4	0.4	0.0	0.9
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.8	0.4	-0.3	-0.4	0.4	-0.9
Arm fat mass (right)	0.2	0.6	1.1	-1.0	0.6	-1.0	0.0	0.9	-0.8
Breastfed as a baby	0.2	0.2	0.6	0.1	-0.2	0.7	-0.3	0.1	0.8
Tense / ‘highly strung’	0.2	0.4	1.2	-0.2	0.5	-0.3	-0.8	-1.1	-0.4
Peak expiratory flow (PEF)	0.2	0.5	0.8	0.7	0.7	-0.9	0.7	0.5	0.7
Birth weight	0.2	0.4	1.2	0.7	-1.1	-0.4	0.2	-0.7	-0.5
Body fat percentage	0.2	0.7	2.6	-0.6	0.7	-0.4	0.5	1.6	-0.3
Whole body fat mass	0.2	0.8	3.0	-0.6	0.6	-0.7	0.5	1.7	-0.5
Leg fat mass (right)	0.2	0.7	2.8	0.2	0.2	-0.2	1.1	1.7	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	-0.0	-0.8	-0.5	0.6	0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.9	-0.1	-0.5	0.8	0.6	0.9	-0.4
Arm fat percentage (left)	0.2	0.8	2.1	-1.1	0.9	-0.6	0.4	1.4	-0.4
Eye problems/disorders: Cataract	0.2	0.2	0.7	-0.4	0.5	0.1	-0.0	0.2	-0.8
Breast cancer (self-reported)	0.2	0.2	0.5	0.5	0.2	0.3	0.7	0.7	-0.2
Financial situation satisfaction	0.2	0.3	0.7	0.0	-0.7	-0.1	-0.2	-0.5	-0.8
Medication: Blood pressure	0.2	0.4	0.9	-0.5	0.9	-0.7	-0.3	0.1	-0.6
Leg fat percentage (left)	0.2	0.9	1.9	0.6	0.8	0.5	1.4	1.4	0.5
Fractured/broken bones in last 5 years	0.2	0.2	1.1	0.2	-0.2	1.1	0.0	0.3	-0.3
Alcohol drinker status: Previous	0.2	0.2	0.7	-0.2	0.8	0.1	-0.5	-0.5	-0.3
Pack years of smoking	0.2	0.3	0.4	0.6	-0.6	0.7	-0.4	0.2	-0.3
Breast Cancer	0.1	0.3	1.1	1.1	0.1	-0.0	0.2	0.3	0.7
Fasting Glucose	0.1	0.1	0.4	0.1	0.5	0.0	-0.3	-0.1	0.7
HDL Cholesterol	0.1	0.1	0.4	0.0	0.3	-0.4	-0.1	-0.4	0.6
Triglycerides	0.1	0.2	0.4	-0.6	-0.4	-0.1	-0.4	0.5	0.5
Blood Eosinophil Count	0.1	0.9	1.7	0.8	-0.6	-0.5	1.3	1.3	0.7
Blood White Count	0.1	0.9	2.5	-0.4	1.1	-0.8	-0.3	-1.0	-1.6
Allergy or Eczema	0.1	0.3	0.9	-0.3	0.5	-0.9	-0.3	-0.2	-0.4
Lung FEV1/FVC ratio	0.1	0.4	1.2	0.3	0.3	-0.3	-0.0	0.7	1.1
Leg fat-free mass (left)	0.1	0.6	1.5	-0.9	0.3	-1.2	-0.5	0.6	-0.6
Current tobacco smoking	0.1	0.2	0.4	0.3	-0.5	0.7	-0.0	-0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	-0.5	-0.5	-0.8	-0.5	0.1	0.0
Body mass index (BMI)	0.1	0.5	1.3	-0.5	0.5	-0.7	0.5	1.1	-0.4
Leg predicted mass (left)	0.1	0.6	1.6	-0.9	0.4	-1.3	-0.6	0.6	-0.6
Nervous feelings	0.1	0.2	0.6	-0.4	0.7	-0.7	-0.3	-0.2	-0.1
Hearing difficulty/problems with background noise	0.1	0.1	0.4	-0.1	-0.3	0.0	0.2	-0.1	-0.6
Weight	0.1	0.4	1.0	-0.4	0.5	-0.8	-0.1	1.0	-0.8
Impedance of arm (right)	0.1	0.4	1.3	-0.7	0.3	-0.3	-1.1	-0.5	0.0
Trunk fat-free mass	0.1	0.4	0.7	-0.6	0.6	-0.6	-0.8	-0.1	-0.7
Hip circumference	0.1	0.5	2.0	-0.2	-1.4	-0.6	-0.0	0.7	-0.2
Number of live births	0.1	0.2	0.6	-0.8	0.4	0.1	-0.0	-0.0	-0.5
Trunk predicted mass	0.1	0.4	0.9	-0.6	0.6	-0.6	-0.9	-0.2	-0.7
Wheeze or whistling in the chest in last year	0.1	0.3	0.7	-0.4	0.8	-0.0	0.1	0.3	-0.8
Alcohol intake frequency.	0.1	0.2	0.9	-0.2	0.4	-0.9	0.1	0.5	-0.0
Comparative height size at age 10	0.1	0.6	1.8	0.7	-0.7	1.3	-0.2	0.2	-0.8
Whole body fat-free mass	0.1	0.4	1.1	-0.5	0.4	-1.1	-0.6	0.3	-0.4
Leg fat-free mass (right)	0.1	0.7	2.8	-0.9	0.4	-1.7	-0.7	0.2	-0.4
Mood swings	0.1	0.2	0.6	0.1	0.8	-0.3	-0.2	0.0	-0.5
Smoking status: Current	0.1	0.2	0.5	0.6	-0.3	0.7	-0.0	-0.5	0.3
Whole body water mass	0.1	0.3	1.1	-0.5	0.3	-1.1	-0.6	0.3	-0.4
Leg predicted mass (right)	0.1	0.8	2.7	-0.9	0.4	-1.6	-0.8	0.3	-0.5
Arm fat mass (left)	0.1	0.6	1.4	-0.9	0.4	-0.8	0.1	1.2	-0.8
Basal metabolic rate	0.1	0.4	1.3	-0.6	0.4	-1.1	-0.5	0.4	-0.5
Age started oral contraceptive pill	0.1	0.2	0.5	0.7	-0.4	-0.3	0.0	0.0	0.5
Leg fat mass (left)	0.1	0.6	2.2	0.1	0.5	-0.3	1.0	1.5	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.2	0.7	-0.1	-0.6	-0.5	-0.1	0.1	-0.9
Height	0.0	0.9	2.9	0.6	-0.6	-0.1	-1.7	1.2	-0.6
Hair Pigment	0.0	0.8	2.3	0.5	-0.2	-1.5	0.7	-0.9	0.9
Impedance of arm (left)	0.0	0.1	0.2	-0.2	-0.3	0.5	-0.5	0.1	0.1
Standing height	0.0	0.4	1.8	-0.1	-0.2	-0.3	-1.3	0.1	-0.8
Arm fat-free mass (right)	0.0	0.2	0.4	0.2	-0.1	0.4	0.1	0.7	-0.6
Arm predicted mass (right)	0.0	0.1	0.5	0.1	-0.1	-0.1	0.2	0.7	-0.4
Alcohol drinker status: Never	0.0	0.0	0.1	0.2	0.1	-0.0	-0.1	-0.3	0.1
Arm fat-free mass (left)	0.0	0.2	0.7	-0.3	0.2	-0.8	-0.1	0.1	-0.6
Impedance of whole body	0.0	0.2	0.8	0.5	0.0	0.9	-0.1	0.0	0.4
Arm predicted mass (left)	0.0	0.2	0.4	-0.2	0.3	-0.6	-0.1	0.2	-0.6

Hub : Genes

PREP

Models

Trait associations