Hub : Genes

WNT6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.1564 0.0598 0.00015 0.018 NA 0.073 NA 0.008 0.0068 NA 1.2e-07 NA 0.049
2 METSIM Adipose 0.0915 0.0538 0.00910 0.005 0.022 0.004 0.024 0.003 0.0570 0.00022 7.6e-02 0.00014 0.110

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.7 2.8 5.5 2.3 -0.2
Bipolar Disorder or Schizophrenia 1.1 2.7 3.3 1.5 1.8
Depressed Affect (Nagel 2018) 0.8 1.7 3.3 -1.8 -0.4
Depression (Nagel 2018) 0.3 0.5 1.0 -1.0 -0.0
Intelligence (Savage-Jansen 2018) 0.4 1.1 2.2 0.1 -1.5
Neuroticism (Nagel 2018) 0.7 1.6 3.0 -1.7 -0.3
Schizophrenia (2018) 1.2 2.5 5.0 -0.0 2.2
Schizophrenia vs Biploar Disorder 1.9 2.5 3.0 -1.7 1.4
Worry (Nagel 2018) 0.5 1.0 1.9 -1.4 -0.2
Alzheimer’s Disease (in mother) 0.3 0.4 0.7 0.8 0.4
Alzheimer’s Disease (in father) 2.3 2.5 5.0 0.1 -2.2
Alzheimer’s Disease (including proxy) 0.2 0.3 0.5 0.1 -0.7
Crohns Disease (2017) 0.2 0.4 0.8 0.9 0.2
Irritable Bowel Disease (IBD) 0.2 0.5 1.0 0.1 1.0
Ulcerative Colitis (UC) 0.9 1.7 2.8 -0.8 1.7
Major Depression (MDD) 0.5 0.6 1.0 -0.5 -1.0
Reaction Time 0.8 1.5 2.6 0.5 1.6
Verbal and Numeric Reasoning (VNR) 0.9 2.2 3.7 0.8 -1.9
Breast Cancer 0.1 0.3 0.6 0.8 0.1
Ovarian Cancer 3.8 5.1 6.2 -2.0 -2.5
Prostate Cancer 0.2 0.3 0.3 0.6 0.5
Age at First Birth 0.3 0.4 0.4 -0.6 -0.6
Bipolar Disorder (2011) 0.4 0.4 0.9 0.0 0.9
Body Mass Index (BMI) (2010) 4.8 6.6 12.5 -3.5 0.9
Coronary Artery Disease (CAD) 0.1 0.2 0.3 0.6 0.0
Crohns Disease (2012) 0.5 0.9 1.7 -0.2 -1.3
Mean Putamen Volume 2.2 2.5 3.7 1.1 -1.9
Fasting Glucose 0.2 0.2 0.4 -0.3 0.6
HbA1C 1.2 1.3 2.4 1.6 -0.4
HDL Cholesterol 1.2 2.0 3.8 -0.4 -1.9
LDL Cholesterol 1.4 2.2 2.7 1.6 1.3
Lupus 1.2 1.7 3.0 0.7 -1.7
Neuroticism (2016) 1.6 2.3 3.5 -1.9 1.0
Primary Biliary Cirrhosis 0.5 0.7 1.2 0.4 -1.1
Rheumatoid Arthritis 0.1 0.1 0.2 -0.3 -0.4
Schizophrenia (2014) 1.3 2.8 5.1 0.7 2.2
Triglycerides 2.3 3.8 7.1 0.7 2.7
Type 2 Diabetes (T2D) (2012) 0.6 0.6 1.2 -1.1 -0.2
Ulcerative Colitis 0.5 0.7 1.2 -0.5 1.1
Blood Eosinophil Count 0.5 3.7 3.9 1.9 -2.0
Blood Platelet Count 0.9 10.2 20.2 -4.5 0.5
Blood Red Count 1.0 9.7 15.2 3.9 -2.0
Blood White Count 1.6 12.1 14.9 3.9 -3.0
Heel T-Score 1.1 8.5 9.3 3.0 2.8
BMI 2.4 14.1 26.3 -5.1 1.3
Height 2.2 41.7 48.4 5.9 -7.0
Waist Hip Ratio (WHR) 2.9 12.9 25.6 5.1 -0.3
Systolic Blood Pressure 0.6 2.8 4.0 2.0 1.3
Smoking Status 1.0 2.4 3.6 -1.1 1.9
Allergy or Eczema 0.5 1.4 1.7 -1.3 -1.1
Cardiovascular Disease 0.0 0.1 0.2 -0.0 -0.4
Hypothyroidism (self reported) 1.4 3.2 6.3 -2.5 0.2
Respiratory disease 2.2 4.8 9.6 -3.1 -0.1
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.7 1.3 0.4
Lung FEV1/FVC ratio 0.4 2.2 2.4 1.5 -1.4
Lung FVC 0.2 1.0 1.5 1.2 0.7
Neuroticism 0.4 1.0 2.0 -1.4 -0.1
Chronotype (morning person) 0.6 1.4 1.8 -1.3 1.1
Hair Pigment 0.1 2.1 4.1 -0.3 2.0
Tanning 0.1 1.7 3.0 0.7 1.7
Hand grip strength (left) 3.9 10.2 16.4 4.0 -2.0
Number of treatments/medications taken 0.8 1.5 2.1 -1.4 1.0
Average weekly spirits intake 1.1 1.4 1.9 -1.4 -0.9
Sensitivity / hurt feelings 0.0 0.1 0.1 0.1 0.4
Frequency of depressed mood in last 2 weeks 1.1 1.5 2.4 -0.8 1.5
Hearing difficulty/problems: Yes 1.1 1.6 3.0 -0.5 -1.7
Relative age of first facial hair 0.1 0.2 0.5 -0.2 -0.7
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.3 -1.2 0.7
Ever used hormone-replacement therapy (HRT) 1.3 1.7 2.0 -1.2 1.4
Ever had hysterectomy (womb removed) 0.4 0.4 0.8 0.9 0.0
Systolic blood pressure, automated reading 0.8 2.3 4.6 -0.3 2.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 0.7 -0.8 -0.9
Angina 0.9 1.2 2.3 -0.1 1.5
Medication for hormone replacement therapy 0.4 0.5 1.0 0.1 1.0
Vitamin and mineral supplements 1.2 1.7 2.0 1.1 -1.4
Supplements: Zinc 2.9 3.2 5.4 -2.3 0.9
Medication: Co-codamol 1.9 2.2 3.0 -1.7 -1.2
Medication: Metformin 0.9 1.3 2.2 0.5 1.5
Diabetes (father) 1.2 1.4 2.1 -0.9 1.4
Diabetes (mother) 0.4 0.6 0.6 0.8 0.7
Severe depression (siblings) 0.1 0.1 0.1 -0.3 -0.2
Pack years adult smoking proportion 2.5 3.8 4.0 -1.9 2.0
Impedance of leg (right) 1.7 8.3 16.6 4.1 -0.1
Leg fat-free mass (left) 0.5 2.7 3.7 -1.9 -1.3
Trunk fat percentage 2.2 8.9 16.9 -4.1 -1.0
Hand grip strength (right) 2.8 7.7 11.8 3.4 -1.9
Townsend deprivation index at recruitment 4.0 5.6 11.0 -0.4 3.3
Current tobacco smoking 1.3 2.2 2.5 -1.4 1.6
Average weekly fortified wine intake 0.4 0.4 0.7 -0.3 -0.9
Maternal smoking around birth 0.3 0.4 0.7 -0.4 -0.8
Fed-up feelings 0.6 1.1 2.2 -1.5 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.5 -1.6 0.0
Relative age voice broke 0.8 1.2 1.6 -0.8 -1.3
Taking other prescription medications 1.7 2.7 4.7 -2.2 0.8
Age when periods started (menarche) 0.2 0.4 0.7 -0.4 -0.8
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.6 0.8 0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.0 5.4 2.3 1.6
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 0.2 0.6
Qualifications: CSEs or equivalent 1.1 1.4 2.8 0.1 1.7
Serious illness, injury or assault to yourself 1.9 2.3 2.9 1.3 1.7
High blood pressure 0.7 2.0 3.9 -2.0 -0.3
Hayfever, allergic rhinitis or eczema 0.4 0.9 1.1 -1.0 -0.8
Multivitamins +/- minerals 1.3 1.6 3.0 0.5 1.7
Stomach or abdominal pain in last month 3.6 4.5 8.3 -0.9 2.9
Supplements: Glucosamine 0.1 0.1 0.1 -0.4 0.3
Diverticular disease/diverticulitis (self-reported) 3.2 3.8 7.5 -0.2 -2.7
Medication: Atenolol 1.6 2.0 2.3 1.5 1.3
Medication: Levothyroxine sodium 0.8 1.3 1.4 -1.1 1.2
Sitting height 0.8 5.4 7.2 2.7 -1.9
Chronic bronchitis/emphysema (father) 0.1 0.1 0.1 -0.3 0.2
High blood pressure (mother) 0.5 0.7 1.3 0.2 1.2
Body mass index (BMI) 3.5 14.8 28.2 -5.3 1.2
Impedance of leg (left) 2.0 9.6 19.0 4.4 -0.3
Leg predicted mass (left) 0.5 2.6 3.6 -1.9 -1.3
Trunk fat mass 1.6 7.0 12.9 -3.6 -1.1
Waist circumference 0.8 2.9 5.8 -2.4 0.2
Number of incorrect matches in round 0.3 0.5 1.0 -0.0 1.0
Past tobacco smoking 1.6 2.9 4.5 2.1 -1.2
Alcohol usually taken with meals 0.7 1.1 2.0 1.4 -0.3
Nervous feelings 1.4 2.5 3.8 -1.9 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.3 -1.1 -0.3
Hearing difficulty/problems with background noise 0.5 0.7 1.5 0.1 -1.2
Hair/balding pattern: Pattern 2 3.1 4.0 4.8 -1.8 2.2
Had menopause 1.5 1.9 2.3 -1.5 1.2
Had other major operations 0.6 0.7 1.3 0.5 1.1
Forced vital capacity (FVC) 2.2 8.5 13.4 3.7 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.2 4.8 2.2 1.3
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 1.9 -1.0 1.4
Qualifications: None of the above 0.7 1.6 2.7 -1.6 0.7
Financial difficulties in last 2 years 0.2 0.2 0.4 -0.6 -0.3
Mouth/teeth dental problems 2.4 3.6 6.9 0.6 -2.6
Heart attack 2.8 3.6 7.2 0.0 2.7
Allergy 1.2 2.7 5.2 2.3 0.5
Pain all over the body in last month 0.5 0.6 0.9 -0.9 0.5
Diabetes (self-reported) 1.5 2.3 4.7 -0.1 2.2
Hayfever/allergic rhinitis (self-reported) 0.0 0.0 0.0 0.1 -0.0
Medication: Ramipril 1.9 2.4 2.7 -1.6 1.5
Medication: Simvastatin 0.2 0.3 0.5 -0.2 0.7
Fluid intelligence score 1.0 2.1 4.2 -0.1 -2.0
Illnesses of siblings 0.7 1.0 1.7 -1.3 -0.5
Neuroticism score 0.3 0.6 1.1 -1.1 0.2
Weight 0.8 4.1 7.7 -2.8 -0.8
Impedance of arm (right) 0.5 2.4 2.7 1.6 -1.4
Arm fat percentage (right) 2.9 11.5 22.6 -4.8 0.6
Trunk fat-free mass 0.1 0.6 0.7 0.9 -0.7
Hip circumference 2.8 11.9 23.6 -4.9 -0.5
Time employed in main current job 1.9 2.1 3.1 -1.8 -1.1
Alcohol intake versus 10 years previously 2.0 3.1 6.0 -0.3 2.5
Father’s age at death 0.8 1.1 1.2 -1.1 1.0
Worrier / anxious feelings 0.2 0.3 0.4 -0.5 -0.6
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.5 6.2 -2.5 0.9
Falls in the last year 0.6 0.9 1.7 -1.3 -0.1
Hair/balding pattern: Pattern 3 3.6 5.4 10.5 -0.6 -3.2
Number of live births 0.4 0.6 1.2 0.0 1.1
Forced expiratory volume in 1-second (FEV1) 3.1 10.3 15.6 4.0 -2.2
Pulse rate 0.1 0.2 0.3 0.2 0.6
Happiness 1.5 1.8 2.3 -1.1 1.5
Noisy workplace 0.4 0.5 0.7 0.9 0.4
Qualifications: A levels/AS levels or equivalent 1.4 3.1 3.5 1.9 -1.6
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 3.0 -1.7 0.2
Mouth/teeth dental problems: Dentures 2.0 3.3 5.9 -0.8 2.4
Asthma 1.3 2.5 5.0 -2.2 0.1
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 4.2 -0.7 2.1
Medication: Cholesterol lowering 1.5 2.3 4.5 0.0 2.1
Depression (self-reported) 1.0 1.2 2.2 -0.4 1.5
Medication: Lansoprazole 0.1 0.1 0.1 -0.3 0.3
Prospective memory result 0.1 0.1 0.2 0.2 0.4
Lung cancer (father) 0.4 0.5 0.9 0.1 0.9
Illnesses of mother 0.2 0.2 0.3 0.6 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.7 8.5 15.9 4.0 -1.0
Pulse wave Arterial Stiffness index 0.4 0.4 0.7 0.3 -0.9
Impedance of arm (left) 0.8 3.7 4.5 1.7 -2.1
Arm fat mass (right) 2.2 9.2 18.4 -4.3 -0.1
Trunk predicted mass 0.1 0.6 0.8 0.9 -0.6
Standing height 2.1 20.8 22.6 4.8 -4.4
Length of working week for main job 0.3 0.4 0.4 -0.6 -0.6
Exposure to tobacco smoke at home 0.7 0.8 1.3 -0.6 1.1
Breastfed as a baby 0.1 0.1 0.1 -0.3 0.2
Tense / ‘highly strung’ 0.2 0.3 0.6 -0.7 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.3 3.5 6.8 -0.5 2.6
Hair/balding pattern: Pattern 4 7.1 17.2 30.9 -1.9 -5.6
Birth weight of first child 0.4 0.8 1.3 -0.6 -1.1
Peak expiratory flow (PEF) 2.6 6.1 9.5 3.1 -1.6
Pulse wave reflection index 2.1 2.6 3.1 1.5 -1.8
Ever highly irritable/argumentative for 2 days 3.3 4.0 5.1 -1.7 2.2
Loud music exposure frequency 0.6 0.7 1.3 -0.3 -1.1
Qualifications: O levels/GCSEs or equivalent 1.9 3.1 5.0 2.2 -1.0
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 2.6 0.1 1.6
Blood clot in the leg (DVT) 0.7 0.9 1.8 -1.3 0.3
Medication: Paracetamol 0.6 1.0 1.6 -1.3 0.7
Headache pain in last month 1.7 3.0 3.6 -1.5 1.9
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.6 0.5 -0.8
Glaucoma (self-reported) 0.5 0.6 0.9 -1.0 -0.4
Gout (self-reported) 0.3 0.4 0.7 -0.8 0.4
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 3.9 -2.0 0.6
Medication: Amlodipine 0.6 0.8 1.6 -0.2 1.3
Medication: Ventolin 100micrograms inhaler 1.8 2.3 3.0 -1.7 -1.2
Birth weight 0.1 0.1 0.2 0.4 0.3
Chronic bronchitis/emphysema (mother) 3.7 4.4 8.0 -2.8 0.9
High blood pressure (siblings) 0.8 1.2 2.4 0.1 1.6
Forced vital capacity (FVC), Best measure 1.9 7.0 12.5 3.5 -1.2
Body fat percentage 2.3 8.9 17.7 -4.2 -0.3
Leg fat percentage (right) 2.1 7.4 14.6 -3.8 0.5
Arm fat-free mass (right) 0.1 0.7 1.5 -0.1 -1.2
Exposure to tobacco smoke outside home 0.8 1.1 2.1 -1.4 0.4
Comparative body size at age 10 0.2 0.5 0.8 -0.9 0.4
Number of full brothers 0.5 0.6 1.0 0.4 1.0
Worry too long after embarrassment 0.7 1.1 2.2 0.2 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.6 2.5 -0.8 1.6
Wheeze or whistling in the chest in last year 2.6 4.6 5.7 -1.9 2.4
Number of children fathered 0.2 0.2 0.5 -0.1 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.5 0.7 0.0
Age at first live birth 0.7 1.2 2.1 1.5 0.4
Pulse wave peak to peak time 0.1 0.2 0.3 -0.2 0.5
Health satisfaction 6.1 7.9 15.1 -0.8 3.9
Shortness of breath walking on level ground 1.3 1.6 2.8 -0.6 1.7
Qualifications: College or University degree 0.2 0.6 0.8 0.9 -0.7
Eye problems/disorders: None of the above 0.0 0.0 0.1 0.2 -0.1
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.8 -0.3 1.3
Emphysema/chronic bronchitis 0.2 0.2 0.3 -0.3 -0.5
Medication for pain relief, constipation, heartburn 2.6 4.4 5.6 1.8 -2.4
Neck or shoulder pain in last month 0.1 0.1 0.2 -0.5 0.1
Medication: Blood pressure 0.4 0.7 1.3 -1.1 0.4
Angina (self-reported) 0.8 1.1 2.2 -0.0 1.5
Migraine (self-reported) 0.9 1.1 1.9 -1.4 0.6
Medication: Ibuprofen 2.5 3.0 3.7 -1.5 1.9
Medication: Allopurinol 1.0 1.3 1.7 -1.0 1.3
Medication: Omeprazole 0.1 0.1 0.1 0.4 0.2
Medication: Seretide 50 evohaler 0.1 0.1 0.1 0.3 -0.1
Mean time to correctly identify matches 1.1 2.0 4.0 -0.1 2.0
Heart disease (mother) 2.5 3.0 5.5 -0.7 -2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.2 4.3 -2.1 0.5
Whole body fat mass 1.8 7.6 15.1 -3.9 -0.5
Leg fat mass (right) 1.8 7.0 14.0 -3.7 0.3
Arm predicted mass (right) 0.2 0.8 1.5 -0.3 -1.2
Pulse rate, automated reading 0.2 0.5 0.7 0.6 -0.8
Alcohol intake frequency. 1.9 4.3 6.8 -2.6 1.3
Comparative height size at age 10 3.1 17.3 23.3 4.8 -3.4
Number of full sisters 0.8 0.9 1.6 -1.3 0.5
Suffer from ‘nerves’ 2.7 4.3 7.6 -2.8 -1.0
Overall health rating 3.1 6.6 8.3 -2.2 2.9
Chest pain or discomfort 2.2 3.2 6.4 -2.5 -0.2
Had major operations 0.7 0.8 1.6 0.0 -1.3
Age at last live birth 0.8 1.1 2.0 1.4 0.5
Family relationship satisfaction 0.6 0.7 1.1 0.6 1.0
Leg pain on walking 0.3 0.3 0.4 -0.6 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.5 -0.7 0.1
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.2 -1.1 -0.2
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.1 -0.2 0.2
Medication: Aspirin 2.5 3.2 4.1 -1.5 2.0
Supplements: Vitamin C 1.7 2.0 2.9 -1.7 -1.1
Knee pain experienced in last month 1.8 2.8 4.9 -2.2 0.8
Hypertension (Self-reported) 0.8 2.2 3.7 -1.9 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 0.9 -1.0 1.0
Illnesses of father: Heart disease 3.3 4.5 5.7 1.8 -2.4
Illnesses of siblings: Diabetes 1.3 1.6 3.1 0.5 1.8
Smoking status: Previous 0.7 1.1 2.1 -1.4 0.3
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.3 4.5 2.1 -2.0
Whole body fat-free mass 0.1 0.6 1.0 -0.4 -1.0
Leg fat-free mass (right) 0.5 2.4 2.7 -1.6 -1.5
Arm fat percentage (left) 3.1 12.3 24.5 -5.0 0.2
Average weekly red wine intake 0.8 1.3 1.5 1.0 -1.2
Handedness (chirality/laterality): Left-handed 1.6 2.0 2.2 1.5 -1.3
Mood swings 0.6 1.2 1.8 -0.7 1.3
Loneliness, isolation 1.6 2.2 3.9 -2.0 0.7
Long-standing illness, disability or infirmity 0.5 0.8 1.2 -1.1 0.6
Ever had bowel cancer screening 2.1 2.4 3.6 -1.9 1.1
Diabetes diagnosed by doctor 0.5 0.8 1.5 0.4 1.2
Ever had stillbirth, spontaneous miscarriage or termination 4.5 4.9 7.1 1.6 2.7
Friendships satisfaction 1.6 2.0 3.7 1.9 -0.5
Qualifications: nursing, teaching 0.1 0.1 0.2 -0.0 -0.4
Commuting to job workplace: Walk 0.7 0.8 1.5 1.2 0.3
Eye problems/disorders: Cataract 0.0 0.1 0.1 0.3 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.3 0.5 -0.2
Medication for cholesterol 0.2 0.2 0.5 0.7 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.0 -1.0 0.7
Back pain experienced in last month 1.2 1.7 2.7 -0.9 1.6
Mineral and other dietary supplements 1.7 2.2 3.9 0.8 -2.0
Breast cancer (self-reported) 0.7 0.9 1.8 0.0 1.3
Asthma (self-reported) 1.4 2.8 5.5 -2.4 0.4
Osteoporosis (self-reported) 0.2 0.2 0.3 -0.6 -0.2
Osteoarthritis (self-reported) 0.5 0.7 1.2 -1.1 -0.3
Medication: Aspirin 2.8 3.6 4.5 -1.6 2.1
Medication: Gliclazide 0.8 0.9 1.3 1.1 -0.8
Illnesses of father: None of the above (group 1) 0.2 0.2 0.3 -0.3 0.6
Smoking status: Current 1.8 2.8 3.6 -1.4 1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.0 4.1 8.0 2.8 0.5
Whole body water mass 0.1 0.7 1.2 -0.3 -1.1
Leg predicted mass (right) 0.5 2.4 2.7 -1.6 -1.5
Arm fat mass (left) 2.4 9.7 19.3 -4.4 -0.2
Number of self-reported non-cancer illnesses 2.1 3.7 7.3 -2.7 0.1
Average weekly champagne plus white wine intake 1.9 2.6 4.4 2.1 -0.9
Miserableness 0.1 0.1 0.2 -0.5 0.0
Guilty feelings 2.1 3.2 6.3 -2.5 0.2
Wears glasses or contact lenses 0.2 0.2 0.2 -0.4 0.5
Ever taken oral contraceptive pill 0.1 0.1 0.2 0.5 0.2
Hearing aid user 1.3 1.4 2.8 -0.1 -1.7
Mother’s age at death 0.4 0.5 0.8 0.4 -0.9
Financial situation satisfaction 0.5 0.6 1.2 -0.1 1.1
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.1 0.3 -1.0
Commuting to job workplace: Public transport 0.7 0.8 1.0 0.8 1.0
Eye problems/disorders: Glaucoma 1.5 1.8 2.8 -1.7 -0.9
Medication: Blood pressure 0.2 0.4 0.5 0.6 -0.7
Pain type(s) experienced in last month: Hip pain 0.5 0.6 0.8 -0.9 -0.6
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.4 -0.5 0.6
High cholesterol (Self-reported) 0.5 0.9 1.7 0.2 1.3
Medication: Bendroflumethiazide 0.7 1.0 1.0 -1.0 -1.0
Medication: Paracetamol 0.9 1.4 1.8 -1.4 1.0
Medication: Lisinopril 0.4 0.5 0.8 0.9 0.4
Medication: Atorvastatin 2.2 2.8 5.1 0.7 2.3
Illnesses of father: High blood pressure 1.8 2.2 2.9 -1.2 1.7
Alcohol drinker status: Never 0.4 0.5 0.5 0.7 0.7
Ever smoked 1.1 1.9 3.8 -2.0 0.1
Basal metabolic rate 0.2 0.8 1.0 -0.8 -1.0
Leg fat percentage (left) 1.9 6.9 13.8 -3.7 0.3
Arm fat-free mass (left) 0.1 0.5 0.7 -0.5 -0.8
Number of operations (self-reported) 0.0 0.0 0.0 0.2 -0.1
Average weekly beer plus cider intake 0.4 0.6 1.2 -1.1 0.1
Irritability 0.4 0.6 1.0 0.4 -1.0
Risk taking 0.6 0.9 1.1 -0.9 -1.1
Ever had prostate specific antigen (PSA) test 1.1 1.2 2.2 0.5 -1.5
Fractured/broken bones in last 5 years 0.3 0.4 0.6 0.8 -0.5
Age started oral contraceptive pill 0.3 0.4 0.4 0.6 -0.6
Diastolic blood pressure, automated reading 0.8 2.5 2.9 1.5 1.7
Ever depressed for a whole week 0.1 0.1 0.2 0.0 0.4
Unable to work because of sickness or disability 0.5 0.7 1.4 -0.1 1.2
Commuting to job workplace: Cycle 2.3 2.7 5.2 2.3 -0.4
Myopia 0.2 0.2 0.4 0.2 0.6
Vascular/heart problems diagnosed by doctor 0.6 1.6 3.1 1.8 -0.2
Cholesterol lowering medication 0.4 0.6 0.8 0.5 0.9
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 0.9 0.1 -0.9
Pain experienced in last month 1.9 3.1 3.5 1.6 -1.9
Supplements: Calcium 1.9 2.1 4.2 -0.2 2.0
Basal cell carcinoma (self-reported) 0.6 0.7 0.9 0.7 -0.9
Heart attack/myocardial infarction (self-reported) 3.4 4.4 8.8 0.1 3.0
Deep venous thrombosis (DVT) (self-reported) 1.0 1.2 2.3 -1.5 0.4
Heart disease (siblings) 1.7 2.1 3.9 0.6 -2.0
Alcohol drinker status: Previous 0.0 0.0 0.0 0.1 0.2
Pack years of smoking 2.3 3.4 3.5 -1.9 1.8
Impedance of whole body 0.9 4.7 7.1 2.7 -1.5
Leg fat mass (left) 1.7 6.7 13.5 -3.7 0.1
Arm predicted mass (left) 0.1 0.3 0.5 -0.2 -0.7